                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  Fusion protease

<130>  130040WO01

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  763
<212>  PRT
<213>  Lactococcus lactis subsp. cremoris

<400>  1

Met Arg Phe Asn His Phe Ser Ile Val Asp Lys Asn Phe Asp Glu Gln 
1               5                   10                  15      


Leu Ala Glu Leu Asp Gln Leu Gly Phe Arg Trp Ser Val Phe Trp Asp 
            20                  25                  30          


Glu Lys Lys Ile Leu Lys Asp Phe Leu Ile Gln Ser Pro Thr Asp Met 
        35                  40                  45              


Thr Val Leu Gln Ala Asn Thr Glu Leu Asp Val Ile Glu Phe Leu Lys 
    50                  55                  60                  


Ser Ser Ile Glu Leu Asp Trp Glu Ile Phe Trp Asn Ile Thr Leu Gln 
65                  70                  75                  80  


Leu Leu Asp Phe Val Pro Asn Phe Asp Phe Glu Ile Gly Lys Ala Thr 
                85                  90                  95      


Glu Phe Ala Lys Lys Leu Asn Leu Pro Gln Arg Asp Val Glu Met Thr 
            100                 105                 110         


Thr Glu Thr Ile Ile Ser Ala Phe Tyr Tyr Leu Leu Cys Ser Arg Arg 
        115                 120                 125             


Lys Ser Gly Met Ile Leu Val Glu His Trp Val Ser Glu Gly Leu Leu 
    130                 135                 140                 


Pro Leu Asp Asn His Tyr His Phe Phe Asn Asp Lys Ser Leu Ala Thr 
145                 150                 155                 160 


Phe Asp Ser Ser Leu Leu Glu Arg Glu Val Val Trp Val Glu Ser Pro 
                165                 170                 175     


Val Asp Thr Glu Gln Lys Gly Lys Asn Asp Leu Ile Lys Ile Gln Ile 
            180                 185                 190         


Ile Arg Pro Lys Ser Thr Glu Lys Leu Pro Val Val Ile Thr Ala Ser 
        195                 200                 205             


Pro Tyr His Leu Gly Ile Asn Glu Lys Ala Asn Asp Leu Ala Leu His 
    210                 215                 220                 


Glu Met Asn Val Asp Leu Glu Lys Lys Asp Ser His Lys Ile His Val 
225                 230                 235                 240 


Gln Gly Lys Leu Pro Gln Lys Arg Pro Ser Glu Thr Lys Glu Leu Pro 
                245                 250                 255     


Ile Val Asp Lys Ala Pro Tyr Arg Phe Thr His Gly Trp Thr Tyr Ser 
            260                 265                 270         


Leu Asn Asp Tyr Phe Leu Thr Arg Gly Phe Ala Ser Ile Tyr Val Ala 
        275                 280                 285             


Gly Val Gly Thr Arg Gly Ser Asn Gly Phe Gln Thr Ser Gly Asp Tyr 
    290                 295                 300                 


Gln Gln Ile Tyr Ser Met Thr Ala Val Ile Asp Trp Leu Asn Gly Arg 
305                 310                 315                 320 


Thr Arg Ala Tyr Thr Ser Arg Lys Lys Thr His Glu Ile Lys Ala Thr 
                325                 330                 335     


Trp Ala Asn Gly Lys Val Ala Met Thr Gly Lys Ser Tyr Leu Gly Thr 
            340                 345                 350         


Met Ala Tyr Gly Ala Ala Thr Thr Gly Val Asp Gly Leu Glu Val Ile 
        355                 360                 365             


Leu Ala Glu Ala Gly Ile Ser Ser Trp Tyr Asn Tyr Tyr Arg Glu Asn 
    370                 375                 380                 


Gly Leu Val Arg Ser Pro Gly Gly Phe Pro Gly Glu Asp Leu Asp Val 
385                 390                 395                 400 


Leu Ala Ala Leu Thr Tyr Ser Arg Asn Leu Asp Gly Ala Asp Tyr Leu 
                405                 410                 415     


Lys Gly Asn Asp Glu Tyr Glu Lys Arg Leu Ala Glu Met Thr Thr Ala 
            420                 425                 430         


Leu Asp Arg Lys Ser Gly Asp Tyr Asn Gln Phe Trp His Asp Arg Asn 
        435                 440                 445             


Tyr Leu Ile Asn Ser Asp Gln Val Arg Ala Asp Val Leu Ile Val His 
    450                 455                 460                 


Gly Leu Gln Asp Trp Asn Val Thr Pro Glu Gln Ala Tyr Asn Phe Trp 
465                 470                 475                 480 


Gln Ala Leu Pro Glu Gly His Ala Lys His Ala Phe Leu His Arg Gly 
                485                 490                 495     


Ala His Ile Tyr Met Asn Ser Trp Gln Ser Ile Asp Phe Ser Glu Thr 
            500                 505                 510         


Ile Asn Ala Tyr Phe Ser Ala Lys Leu Leu Asp Arg Asp Leu Asn Leu 
        515                 520                 525             


Asn Leu Pro Pro Val Ile Leu Gln Glu Asn Ser Lys Glu Gln Val Trp 
    530                 535                 540                 


Ser Ala Val Ser Lys Phe Gly Gly Asp Asp Gln Leu Lys Leu Pro Leu 
545                 550                 555                 560 


Gly Lys Thr Ala Val Ser Phe Ala Gln Phe Asp Asn His Tyr Asp Asp 
                565                 570                 575     


Glu Ser Phe Lys Lys Tyr Ser Lys Asp Phe Asn Val Phe Lys Lys Asp 
            580                 585                 590         


Leu Phe Glu Asn Lys Ala Asn Glu Ala Val Ile Asp Leu Glu Leu Pro 
        595                 600                 605             


Ser Glu Leu Thr Ile Asn Gly Pro Ile Glu Leu Glu Ile Arg Leu Lys 
    610                 615                 620                 


Leu Asn Asp Ser Lys Gly Leu Leu Ser Ala Gln Ile Leu Asp Phe Gly 
625                 630                 635                 640 


Pro Lys Lys Arg Leu Glu Asp Lys Ala Arg Val Lys Asp Phe Lys Val 
                645                 650                 655     


Leu Asp Arg Gly Arg Asn Phe Met Leu Asp Asp Leu Val Glu Leu Pro 
            660                 665                 670         


Leu Val Glu Ser Pro Tyr Gln Leu Val Thr Lys Gly Phe Thr Asn Leu 
        675                 680                 685             


Gln Asn Lys Asp Leu Leu Thr Val Ser Asp Leu Lys Ala Asp Glu Trp 
    690                 695                 700                 


Phe Thr Leu Lys Phe Glu Leu Gln Pro Thr Ile Tyr His Leu Glu Lys 
705                 710                 715                 720 


Ala Asp Lys Leu Arg Val Ile Leu Tyr Ser Thr Asp Phe Glu His Thr 
                725                 730                 735     


Val Arg Asp Asn Arg Lys Val Thr Tyr Glu Ile Asp Leu Ser Gln Ser 
            740                 745                 750         


Lys Leu Ile Ile Pro Ile Glu Ser Val Lys Lys 
        755                 760             


<210>  2
<211>  182
<212>  PRT
<213>  human rhinovirus 14

<400>  2

Gly Pro Asn Thr Glu Phe Ala Leu Ser Leu Leu Arg Lys Asn Ile Met 
1               5                   10                  15      


Thr Ile Thr Thr Ser Lys Gly Glu Phe Thr Gly Leu Gly Ile His Asp 
            20                  25                  30          


Arg Val Cys Val Ile Pro Thr His Ala Gln Pro Gly Asp Asp Val Leu 
        35                  40                  45              


Val Asn Gly Gln Lys Ile Arg Val Lys Asp Lys Tyr Lys Leu Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Asn Leu Glu Leu Thr Val Leu Thr Leu Asp Arg Asn 
65                  70                  75                  80  


Glu Lys Phe Arg Asp Ile Arg Gly Phe Ile Ser Glu Asp Leu Glu Gly 
                85                  90                  95      


Val Asp Ala Thr Leu Val Val His Ser Asn Asn Phe Thr Asn Thr Ile 
            100                 105                 110         


Leu Glu Val Gly Pro Val Thr Met Ala Gly Leu Ile Asn Leu Ser Ser 
        115                 120                 125             


Thr Pro Thr Asn Arg Met Ile Arg Tyr Asp Tyr Ala Thr Lys Thr Gly 
    130                 135                 140                 


Gln Cys Gly Gly Val Leu Cys Ala Thr Gly Lys Ile Phe Gly Ile His 
145                 150                 155                 160 


Val Gly Gly Asn Gly Arg Gln Gly Phe Ser Ala Gln Leu Lys Lys Gln 
                165                 170                 175     


Tyr Phe Val Glu Lys Gln 
            180         


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker 1

<400>  3

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker 2

<400>  4

Gly Ser Ser Gly Ser Gly Gly Ser Gly 
1               5                   


<210>  5
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  His6 tag

<400>  5

Met His His His His His His Gly Gly Ser Ser Gly Ser Gly Ser Glu 
1               5                   10                  15      


Leu Arg Thr Gln Ser 
            20      


<210>  6
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DsbC based sequence

<400>  6

Met Asp Asp Ala Ala Ile Gln Gln Thr Leu Ala Lys Met Gly Ile Lys 
1               5                   10                  15      


Ser Ser Asp Ile Gln Pro Ala Pro Val Ala Gly Met Lys Thr Val Leu 
            20                  25                  30          


Thr Asn Ser Gly Val Leu Tyr Ile Thr Asp Asp Gly Lys His Ile Ile 
        35                  40                  45              


Gln Gly Pro Met Tyr Asp Val Ser Gly Thr Ala Pro Val Asn Val Thr 
    50                  55                  60                  


Asn Lys Met Leu Leu Lys Gln Leu Asn Ala Leu Glu Lys Glu Met Ile 
65                  70                  75                  80  


Val Tyr Lys Ala Pro Gln Glu Lys His Val Ile Thr Val Phe Thr Asp 
                85                  90                  95      


Ile Thr Cys Gly Tyr Cys His Lys Leu His Glu Gln Met Ala Asp Tyr 
            100                 105                 110         


Asn Ala Leu Gly Ile Thr Val Arg Tyr Leu Ala Phe Pro Arg Gln Gly 
        115                 120                 125             


Leu Asp Ser Asp Ala Glu Lys Glu Met Lys Ala Ile Trp Cys Ala Lys 
    130                 135                 140                 


Asp Lys Asn Lys Ala Phe Asp Asp Val Met Ala Gly Lys Ser Val Ala 
145                 150                 155                 160 


Pro Ala Ser Cys Asp Val Asp Ile Ala Asp His Tyr Val Leu Gly Val 
                165                 170                 175     


Gln Leu Gly Val Ser Gly Thr Pro Ala Val Val Leu Ser Asn Gly Thr 
            180                 185                 190         


Leu Val Pro Gly Tyr Gln Pro Pro Lys Glu Met Lys Glu Phe Leu Asp 
        195                 200                 205             


Glu His Gln Lys Met Thr Ser Gly Lys Gly Ser Gly Ser Gly His His 
    210                 215                 220                 


His His His His Gly Gly Ser Ser Gly Ser Gly Ser Glu Leu Arg Thr 
225                 230                 235                 240 


Gln Ser 
        


<210>  7
<211>  174
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RL9 based sequence

<400>  7

Met Lys Val Ile Leu Leu Arg Asp Val Pro Lys Ile Gly Lys Lys Gly 
1               5                   10                  15      


Glu Ile Lys Glu Val Ser Asp Gly Tyr Ala Arg Asn Tyr Leu Ile Pro 
            20                  25                  30          


Arg Gly Phe Ala Lys Glu Tyr Thr Glu Gly Leu Glu Arg Ala Ile Lys 
        35                  40                  45              


His Glu Lys Glu Ile Glu Lys Arg Lys Lys Glu Arg Glu Arg Glu Glu 
    50                  55                  60                  


Ser Glu Lys Ile Leu Lys Glu Leu Lys Lys Arg Thr His Val Val Lys 
65                  70                  75                  80  


Val Lys Ala Gly Glu Gly Gly Lys Ile Phe Gly Ala Val Thr Ala Ala 
                85                  90                  95      


Thr Val Ala Glu Glu Ile Ser Lys Thr Thr Gly Leu Lys Leu Asp Lys 
            100                 105                 110         


Arg Trp Phe Lys Leu Asp Lys Pro Ile Lys Glu Leu Gly Glu Tyr Ser 
        115                 120                 125             


Leu Glu Val Ser Leu Pro Gly Gly Val Lys Asp Thr Ile Lys Ile Arg 
    130                 135                 140                 


Val Glu Arg Glu Glu Gly Ser Gly Ser Gly His His His His His His 
145                 150                 155                 160 


Gly Gly Ser Ser Gly Ser Gly Ser Glu Leu Arg Thr Gln Ser 
                165                 170                 


<210>  8
<211>  520
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NusA based sequence

<400>  8

Met Asn Lys Glu Ile Leu Ala Val Val Glu Ala Val Ser Asn Glu Lys 
1               5                   10                  15      


Ala Leu Pro Arg Glu Lys Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala 
            20                  25                  30          


Thr Ala Thr Lys Lys Lys Tyr Glu Gln Glu Ile Asp Val Arg Val Gln 
        35                  40                  45              


Ile Asp Arg Lys Ser Gly Asp Phe Asp Thr Phe Arg Arg Trp Leu Val 
    50                  55                  60                  


Val Asp Glu Val Thr Gln Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala 
65                  70                  75                  80  


Arg Tyr Glu Asp Glu Ser Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln 
                85                  90                  95      


Ile Glu Ser Val Thr Phe Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln 
            100                 105                 110         


Val Ile Val Gln Lys Val Arg Glu Ala Glu Arg Ala Met Val Val Asp 
        115                 120                 125             


Gln Phe Arg Glu His Glu Gly Glu Ile Ile Thr Gly Val Val Lys Lys 
    130                 135                 140                 


Val Asn Arg Asp Asn Ile Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala 
145                 150                 155                 160 


Val Ile Leu Arg Glu Asp Met Leu Pro Arg Glu Asn Phe Arg Pro Gly 
                165                 170                 175     


Asp Arg Val Arg Gly Val Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly 
            180                 185                 190         


Ala Gln Leu Phe Val Thr Arg Ser Lys Pro Glu Met Leu Ile Glu Leu 
        195                 200                 205             


Phe Arg Ile Glu Val Pro Glu Ile Gly Glu Glu Val Ile Glu Ile Lys 
    210                 215                 220                 


Ala Ala Ala Arg Asp Pro Gly Ser Arg Ala Lys Ile Ala Val Lys Thr 
225                 230                 235                 240 


Asn Asp Lys Arg Ile Asp Pro Val Gly Ala Cys Val Gly Met Arg Gly 
                245                 250                 255     


Ala Arg Val Gln Ala Val Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp 
            260                 265                 270         


Ile Val Leu Trp Asp Asp Asn Pro Ala Gln Phe Val Ile Asn Ala Met 
        275                 280                 285             


Ala Pro Ala Asp Val Ala Ser Ile Val Val Asp Glu Asp Lys His Thr 
    290                 295                 300                 


Met Asp Ile Ala Val Glu Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg 
305                 310                 315                 320 


Asn Gly Gln Asn Val Arg Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu 
                325                 330                 335     


Asn Val Met Thr Val Asp Asp Leu Gln Ala Lys His Gln Ala Glu Ala 
            340                 345                 350         


His Ala Ala Ile Asp Thr Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp 
        355                 360                 365             


Phe Ala Thr Val Leu Val Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu 
    370                 375                 380                 


Ala Tyr Val Pro Met Lys Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu 
385                 390                 395                 400 


Pro Thr Val Glu Ala Leu Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr 
                405                 410                 415     


Ile Ala Gln Ala Gln Glu Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp 
            420                 425                 430         


Asp Leu Leu Asn Leu Glu Gly Val Asp Arg Asp Leu Ala Phe Lys Leu 
        435                 440                 445             


Ala Ala Arg Gly Val Cys Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile 
    450                 455                 460                 


Asp Asp Leu Ala Asp Ile Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala 
465                 470                 475                 480 


Leu Ile Met Ala Ala Arg Asn Ile Cys Trp Phe Gly Asp Glu Ala Gly 
                485                 490                 495     


Ser Gly Ser Gly His His His His His His Gly Gly Ser Ser Gly Ser 
            500                 505                 510         


Gly Ser Glu Leu Arg Thr Gln Ser 
        515                 520 


<210>  9
<211>  396
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBP based sequence

<400>  9

Met His His His His His His Gly Ser Gly Ser Gly Lys Ile Glu Glu 
1               5                   10                  15      


Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu 
            20                  25                  30          


Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr 
        35                  40                  45              


Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala 
    50                  55                  60                  


Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly 
65                  70                  75                  80  


Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala 
                85                  90                  95      


Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn 
            100                 105                 110         


Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile 
        115                 120                 125             


Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile 
    130                 135                 140                 


Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met 
145                 150                 155                 160 


Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp 
                165                 170                 175     


Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp 
            180                 185                 190         


Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val 
        195                 200                 205             


Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile 
    210                 215                 220                 


Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly 
225                 230                 235                 240 


Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val 
                245                 250                 255     


Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly 
            260                 265                 270         


Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala 
        275                 280                 285             


Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala 
    290                 295                 300                 


Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu 
305                 310                 315                 320 


Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala 
                325                 330                 335     


Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp 
            340                 345                 350         


Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr 
        355                 360                 365             


Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Arg Ile Thr Lys Gly Gly 
    370                 375                 380                 


Ser Ser Gly Ser Gly Ser Glu Leu Arg Thr Gln Ser 
385                 390                 395     


<210>  10
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Trx based sequence

<400>  10

Met His His His His His His Gly Ser Gly Ser Gly Ser Asp Lys Ile 
1               5                   10                  15      


Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp 
            20                  25                  30          


Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys 
        35                  40                  45              


Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys 
    50                  55                  60                  


Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro 
65                  70                  75                  80  


Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly 
                85                  90                  95      


Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys 
            100                 105                 110         


Glu Phe Leu Asp Ala Asn Leu Ala Gly Gly Ser Ser Gly Ser Gly Ser 
        115                 120                 125             


Glu Leu Arg Thr Gln Ser 
    130                 


<210>  11
<211>  181
<212>  PRT
<213>  human rhinovirus 14

<400>  11

Gly Pro Asn Thr Glu Phe Ala Leu Ser Leu Leu Arg Lys Asn Ile Met 
1               5                   10                  15      


Thr Ile Thr Thr Ser Lys Gly Glu Phe Thr Gly Leu Gly Ile His Asp 
            20                  25                  30          


Arg Val Cys Val Ile Pro Thr His Ala Gln Pro Gly Asp Asp Val Leu 
        35                  40                  45              


Val Asn Gly Gln Lys Ile Arg Val Lys Asp Lys Tyr Lys Leu Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Asn Leu Glu Leu Thr Val Leu Thr Leu Asp Arg Asn 
65                  70                  75                  80  


Glu Lys Phe Arg Asp Ile Arg Gly Phe Ile Ser Glu Asp Leu Glu Gly 
                85                  90                  95      


Val Asp Ala Thr Leu Val Val His Ser Asn Asn Phe Thr Asn Thr Ile 
            100                 105                 110         


Leu Glu Val Gly Pro Val Thr Met Ala Gly Leu Ile Asn Leu Ser Ser 
        115                 120                 125             


Thr Pro Thr Asn Arg Met Ile Arg Tyr Asp Tyr Ala Thr Lys Thr Gly 
    130                 135                 140                 


Gln Cys Gly Gly Val Leu Cys Ala Thr Gly Lys Ile Phe Gly Ile His 
145                 150                 155                 160 


Val Gly Gly Asn Gly Arg Gln Gly Phe Ser Ala Gln Leu Lys Lys Gln 
                165                 170                 175     


Tyr Phe Val Glu Lys 
            180     


<210>  12
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker 3

<400>  12

Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser 
1               5                   10      


<210>  13
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion partner 1

<400>  13

Met His His His His His His Gly Gly Ser Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser 
            20      


<210>  14
<211>  174
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion partner 2

<400>  14

Met Lys Val Ile Leu Leu Arg Asp Val Pro Lys Ile Gly Lys Lys Gly 
1               5                   10                  15      


Glu Ile Lys Glu Val Ser Asp Gly Tyr Ala Arg Asn Tyr Leu Ile Pro 
            20                  25                  30          


Arg Gly Phe Ala Lys Glu Tyr Thr Glu Gly Leu Glu Arg Ala Ile Lys 
        35                  40                  45              


His Glu Lys Glu Ile Glu Lys Arg Lys Lys Glu Arg Glu Arg Glu Glu 
    50                  55                  60                  


Ser Glu Lys Ile Leu Lys Glu Leu Lys Lys Arg Thr His Val Val Lys 
65                  70                  75                  80  


Val Lys Ala Gly Glu Gly Gly Lys Ile Phe Gly Ala Val Thr Ala Ala 
                85                  90                  95      


Thr Val Ala Glu Glu Ile Ser Lys Thr Thr Gly Leu Lys Leu Asp Lys 
            100                 105                 110         


Arg Trp Phe Lys Leu Asp Lys Pro Ile Lys Glu Leu Gly Glu Tyr Ser 
        115                 120                 125             


Leu Glu Val Ser Leu Pro Gly Gly Val Lys Asp Thr Ile Lys Ile Arg 
    130                 135                 140                 


Val Glu Arg Glu Glu Gly Ser Gly Ser Gly His His His His His His 
145                 150                 155                 160 


Gly Gly Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
                165                 170                 


<210>  15
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion partner 3

<400>  15

Met His His His His His His Gly Ser Gly Ser Gly Ser Asp Lys Ile 
1               5                   10                  15      


Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp Val Leu Lys Ala Asp 
            20                  25                  30          


Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp Cys Gly Pro Cys Lys 
        35                  40                  45              


Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp Glu Tyr Gln Gly Lys 
    50                  55                  60                  


Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn Pro Gly Thr Ala Pro 
65                  70                  75                  80  


Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu Leu Phe Lys Asn Gly 
                85                  90                  95      


Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser Lys Gly Gln Leu Lys 
            100                 105                 110         


Glu Phe Leu Asp Ala Asn Leu Ala Gly Gly Ser Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Gly Ser Gly Ser 
    130                 


<210>  16
<211>  83
<212>  PRT
<213>  Thermotoga maritima

<400>  16

Met Ala His Lys Lys Ser Gly Gly Val Ala Lys Asn Gly Arg Asp Ser 
1               5                   10                  15      


Leu Pro Lys Tyr Leu Gly Val Lys Val Gly Asp Gly Gln Ile Val Lys 
            20                  25                  30          


Ala Gly Asn Ile Leu Val Arg Gln Arg Gly Thr Arg Phe Tyr Pro Gly 
        35                  40                  45              


Lys Asn Val Gly Met Gly Arg Asp Phe Thr Leu Phe Ala Leu Lys Asp 
    50                  55                  60                  


Gly Arg Val Lys Phe Glu Thr Lys Asn Asn Lys Lys Tyr Val Ser Val 
65                  70                  75                  80  


Tyr Glu Glu 
            


<210>  17
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker + HRV14 3C site

<400>  17

Ser Ser Ser Gly Gly Ser Glu Val Leu Phe Gln Gly Pro 
1               5                   10              


<210>  18
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  18

Ile Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr Arg Gln 
            20                  25                  30          


Arg Tyr 
        


<210>  19
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  20
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  K34R GLP-1(7-37)

<400>  20

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  21
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RL9-HRV14 3C sequence

<400>  21

Met Lys Val Ile Leu Leu Arg Asp Val Pro Lys Ile Gly Lys Lys Gly 
1               5                   10                  15      


Glu Ile Lys Glu Val Ser Asp Gly Tyr Ala Arg Asn Tyr Leu Ile Pro 
            20                  25                  30          


Arg Gly Phe Ala Lys Glu Tyr Thr Glu Gly Leu Glu Arg Ala Ile Lys 
        35                  40                  45              


His Glu Lys Glu Ile Glu Lys Arg Lys Lys Glu Arg Glu Arg Glu Glu 
    50                  55                  60                  


Ser Glu Lys Ile Leu Lys Glu Leu Lys Lys Arg Thr His Val Val Lys 
65                  70                  75                  80  


Val Lys Ala Gly Glu Gly Gly Lys Ile Phe Gly Ala Val Thr Ala Ala 
                85                  90                  95      


Thr Val Ala Glu Glu Ile Ser Lys Thr Thr Gly Leu Lys Leu Asp Lys 
            100                 105                 110         


Arg Trp Phe Lys Leu Asp Lys Pro Ile Lys Glu Leu Gly Glu Tyr Ser 
        115                 120                 125             


Leu Glu Val Ser Leu Pro Gly Gly Val Lys Asp Thr Ile Lys Ile Arg 
    130                 135                 140                 


Val Glu Arg Glu Glu Ser Ser Ser Gly Ser Ser Gly Ser Ser Gly Ser 
145                 150                 155                 160 


Ser Gly Pro Asn Thr Glu Phe Ala Leu Ser Leu Leu Arg Lys Asn Ile 
                165                 170                 175     


Met Thr Ile Thr Thr Ser Lys Gly Glu Phe Thr Gly Leu Gly Ile His 
            180                 185                 190         


Asp Arg Val Cys Val Ile Pro Thr His Ala Gln Pro Gly Asp Asp Val 
        195                 200                 205             


Leu Val Asn Gly Gln Lys Ile Arg Val Lys Asp Lys Tyr Lys Leu Val 
    210                 215                 220                 


Asp Pro Glu Asn Ile Asn Leu Glu Leu Thr Val Leu Thr Leu Asp Arg 
225                 230                 235                 240 


Asn Glu Lys Phe Arg Asp Ile Arg Gly Phe Ile Ser Glu Asp Leu Glu 
                245                 250                 255     


Gly Val Asp Ala Thr Leu Val Val His Ser Asn Asn Phe Thr Asn Thr 
            260                 265                 270         


Ile Leu Glu Val Gly Pro Val Thr Met Ala Gly Leu Ile Asn Leu Ser 
        275                 280                 285             


Ser Thr Pro Thr Asn Arg Met Ile Arg Tyr Asp Tyr Ala Thr Lys Thr 
    290                 295                 300                 


Gly Gln Cys Gly Gly Val Leu Cys Ala Thr Gly Lys Ile Phe Gly Ile 
305                 310                 315                 320 


His Val Gly Gly Asn Gly Arg Gln Gly Phe Ser Ala Gln Leu Lys Lys 
                325                 330                 335     


Gln Tyr Phe Val Glu Lys Gln 
            340             


<210>  22
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker + HAV site

<400>  22

Gly Gly Ser Ser Gly Ser Gly Ser Glu Leu Arg Thr Gln Ser 
1               5                   10                  


<210>  23
<211>  182
<212>  PRT
<213>  Coxsackievirus


<220>
<221>  MISC_FEATURE
<222>  (183)..(183)
<223>  Glutamine at position 183 has been deleted

<400>  23

Gly Pro Ala Phe Glu Phe Ala Val Ala Met Met Lys Arg Asn Ser Ser 
1               5                   10                  15      


Thr Val Lys Thr Glu Tyr Gly Glu Phe Thr Met Leu Gly Ile Tyr Asp 
            20                  25                  30          


Arg Trp Ala Val Leu Pro Arg His Ala Lys Pro Gly Pro Thr Ile Leu 
        35                  40                  45              


Met Asn Asp Gln Glu Val Gly Val Leu Asp Ala Lys Glu Leu Val Asp 
    50                  55                  60                  


Lys Asp Gly Thr Asn Leu Glu Leu Thr Leu Leu Lys Leu Asn Arg Asn 
65                  70                  75                  80  


Glu Lys Phe Arg Asp Ile Arg Gly Phe Leu Ala Lys Glu Glu Val Glu 
                85                  90                  95      


Val Asn Glu Ala Val Leu Ala Ile Asn Thr Ser Lys Phe Pro Asn Met 
            100                 105                 110         


Tyr Ile Pro Val Gly Gln Val Thr Glu Tyr Gly Phe Leu Asn Leu Gly 
        115                 120                 125             


Gly Thr Pro Thr Lys Arg Met Leu Met Tyr Asn Phe Pro Thr Arg Ala 
    130                 135                 140                 


Gly Gln Cys Gly Gly Val Leu Met Ser Thr Gly Lys Val Leu Gly Ile 
145                 150                 155                 160 


His Val Gly Gly Asn Gly His Gln Gly Phe Ser Ala Ala Leu Leu Lys 
                165                 170                 175     


His Tyr Phe Asn Asp Glu 
            180         


<210>  24
<211>  755
<212>  PRT
<213>  Streptococcus suis


<220>
<221>  MISC_FEATURE
<222>  (212)..(213)
<223>  QG has been substituted with ET

<400>  24

Met Arg Phe Asn Gln Phe Ser Phe Ile Lys Lys Glu Thr Ser Val Tyr 
1               5                   10                  15      


Leu Gln Glu Leu Asp Thr Leu Gly Phe Gln Leu Ile Pro Asp Ala Ser 
            20                  25                  30          


Ser Lys Thr Asn Leu Glu Thr Phe Val Arg Lys Cys His Phe Leu Thr 
        35                  40                  45              


Ala Asn Thr Asp Phe Ala Leu Ser Asn Met Ile Ala Glu Trp Asp Thr 
    50                  55                  60                  


Asp Leu Leu Thr Phe Phe Gln Ser Asp Arg Glu Leu Thr Asp Gln Ile 
65                  70                  75                  80  


Phe Tyr Gln Val Ala Phe Gln Leu Leu Gly Phe Val Pro Gly Met Asp 
                85                  90                  95      


Tyr Thr Asp Val Met Asp Phe Val Glu Lys Ser Asn Phe Pro Ile Val 
            100                 105                 110         


Tyr Gly Asp Ile Ile Asp Asn Leu Tyr Gln Leu Leu Asn Thr Arg Thr 
        115                 120                 125             


Lys Ser Gly Asn Thr Leu Ile Asp Gln Leu Val Ser Asp Asp Leu Ile 
    130                 135                 140                 


Pro Glu Asp Asn His Tyr His Phe Phe Asn Gly Lys Ser Met Ala Thr 
145                 150                 155                 160 


Phe Ser Thr Lys Asn Leu Ile Arg Glu Val Val Tyr Val Glu Thr Pro 
                165                 170                 175     


Val Asp Thr Ala Gly Thr Gly Gln Thr Asp Ile Val Lys Leu Ser Ile 
            180                 185                 190         


Leu Arg Pro His Phe Asp Gly Lys Ile Pro Ala Val Ile Thr Asn Ser 
        195                 200                 205             


Pro Tyr His Glu Thr Val Asn Asp Val Ala Ser Asp Lys Ala Leu His 
    210                 215                 220                 


Lys Met Glu Gly Glu Leu Ala Glu Lys Gln Val Gly Thr Ile Gln Val 
225                 230                 235                 240 


Lys Gln Ala Ser Ile Thr Lys Leu Asp Leu Asp Gln Arg Asn Leu Pro 
                245                 250                 255     


Val Ser Pro Ala Thr Glu Lys Leu Gly His Ile Thr Ser Tyr Ser Leu 
            260                 265                 270         


Asn Asp Tyr Phe Leu Ala Arg Gly Phe Ala Ser Leu His Val Ser Gly 
        275                 280                 285             


Val Gly Thr Leu Gly Ser Thr Gly Tyr Met Thr Ser Gly Asp Tyr Gln 
    290                 295                 300                 


Gln Val Glu Gly Tyr Lys Ala Val Ile Asp Trp Leu Asn Gly Arg Thr 
305                 310                 315                 320 


Lys Ala Tyr Thr Asp His Thr Arg Ser Leu Glu Val Lys Ala Asp Trp 
                325                 330                 335     


Ala Asn Gly Lys Val Ala Thr Thr Gly Leu Ser Tyr Leu Gly Thr Met 
            340                 345                 350         


Ser Asn Ala Leu Ala Thr Thr Gly Val Asp Gly Leu Glu Val Ile Ile 
        355                 360                 365             


Ala Glu Ala Gly Ile Ser Ser Trp Tyr Asp Tyr Tyr Arg Glu Asn Gly 
    370                 375                 380                 


Leu Val Thr Ser Pro Gly Gly Tyr Pro Gly Glu Asp Leu Asp Ser Leu 
385                 390                 395                 400 


Thr Ala Leu Thr Tyr Ser Lys Ser Leu Gln Ala Gly Asp Phe Leu Arg 
                405                 410                 415     


Asn Lys Ala Ala Tyr Glu Lys Gly Leu Ala Ala Glu Arg Ala Ala Leu 
            420                 425                 430         


Asp Arg Thr Ser Gly Asp Tyr Asn Gln Tyr Trp His Asp Arg Asn Tyr 
        435                 440                 445             


Leu Leu His Ala Asp Arg Val Lys Cys Glu Val Val Phe Thr His Gly 
    450                 455                 460                 


Ser Gln Asp Trp Asn Val Lys Pro Ile His Val Trp Asn Met Phe His 
465                 470                 475                 480 


Ala Leu Pro Ser His Ile Lys Lys His Leu Phe Phe His Asn Gly Ala 
                485                 490                 495     


His Val Tyr Met Asn Asn Trp Gln Ser Ile Asp Phe Arg Glu Ser Met 
            500                 505                 510         


Asn Ala Leu Leu Ser Gln Lys Leu Leu Gly Tyr Glu Asn Asn Tyr Gln 
        515                 520                 525             


Leu Pro Thr Val Ile Trp Gln Asp Asn Ser Gly Glu Gln Thr Trp Thr 
    530                 535                 540                 


Thr Leu Asp Thr Phe Gly Gly Glu Asn Glu Thr Val Leu Pro Leu Gly 
545                 550                 555                 560 


Thr Gly Ser Gln Thr Val Ala Asn Gln Tyr Thr Gln Glu Asp Phe Glu 
                565                 570                 575     


Arg Tyr Gly Lys Ser Tyr Ser Ala Phe His Gln Asp Leu Tyr Ala Gly 
            580                 585                 590         


Lys Ala Asn Gln Ile Ser Ile Glu Leu Pro Val Thr Glu Gly Leu Leu 
        595                 600                 605             


Leu Asn Gly Gln Val Thr Leu Lys Leu Arg Val Ala Ser Ser Val Ala 
    610                 615                 620                 


Lys Gly Leu Leu Ser Ala Gln Leu Leu Asp Lys Gly Asn Lys Lys Arg 
625                 630                 635                 640 


Leu Ala Pro Ile Pro Ala Pro Lys Ala Arg Leu Ser Leu Asp Asn Gly 
                645                 650                 655     


Arg Tyr His Ala Gln Glu Asn Leu Val Glu Leu Pro Tyr Val Glu Met 
            660                 665                 670         


Pro Gln Arg Leu Val Thr Lys Gly Phe Met Asn Leu Gln Asn Arg Thr 
        675                 680                 685             


Asp Leu Met Thr Val Glu Glu Val Val Pro Gly Gln Trp Met Asn Leu 
    690                 695                 700                 


Thr Trp Lys Leu Gln Pro Thr Ile Tyr Gln Leu Lys Lys Gly Asp Val 
705                 710                 715                 720 


Leu Glu Leu Ile Leu Tyr Thr Thr Asp Phe Glu Cys Thr Val Arg Asp 
                725                 730                 735     


Asn Ser Gln Trp Gln Ile His Leu Asp Leu Ser Gln Ser Gln Leu Ile 
            740                 745                 750         


Leu Pro His 
        755 


