﻿               SEQUENCE LISTING

<110> Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

<120> ISOFORMS OF GATA6 AND NKX2-1 AS MARKERS FOR DIAGNOSIS AND THERAPY OF CANCER AND AS TARGETS FOR ANTI-CANCER THERAPY

<130> W1042 PCT S3

<150> EP13 16 8629.7   
<151> 2013-05-21
<150> EP13 16 8636.2   
<151> 2013-05-21

<160> 159

<170> BiSSAP 1.2

<210> 1
<211> 3770
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3770
<223> /mol_type="unassigned RNA"
      /note="Gata6-Em"
      /organism="Homo sapiens"

<400> 1
gacccacagc cuggcacccu ucggcgagcg cuguuuguuu agggcucggu gaguccaauc       60

aggagcccag gcugcaguuu uccggcagag caguaagagg cgccuccucu cuccuuuuua      120

uucaccagca gcgcggcgca gaccccggac ucgcgcucgc ccgcuggcgc ccucggcuuc      180

ucuccgcgcc ugggagcacc cuccgccgcg gccguucucc augcgcagcg cccgcccgag      240

gagcuagacg ucagcuugga gcggcgccgg accguggaug gccuugacug acggcggcug      300

gugcuugccg aagcgcuucg gggccgcggg ugcggacgcc agcgacucca gagccuuucc      360

agcgcgggag cccuccacgc cgccuucccc caucucuucc ucguccuccu ccugcucccg      420

gggcggagag cggggccccg gcggcgccag caacugcggg acgccucagc ucgacacgga      480

ggcggcggcc ggacccccgg cccgcucgcu gcugcucagu uccuacgcuu cgcaucccuu      540

cggggcuccc cacggaccuu cggcgccugg ggucgcgggc cccgggggca accugucgag      600

cugggaggac uugcugcugu ucacugaccu cgaccaagcc gcgaccgcca gcaagcugcu      660

gugguccagc cgcggcgcca agcugagccc cuucgcaccc gagcagccgg aggagaugua      720

ccagacccuc gccgcucucu ccagccaggg uccggccgcc uacgacggcg cgcccggcgg      780

cuucgugcac ucugcggccg cggcggcagc agccgcggcg gcggccagcu ccccggucua      840

cgugcccacc acccgcgugg guuccaugcu gcccggccua ccguaccacc ugcagggguc      900

gggcaguggg ccagccaacc acgcgggcgg cgcgggcgcg caccccggcu ggccucaggc      960

cucggccgac agcccuccau acggcagcgg aggcggcgcg gcuggcggcg gggccgcggg     1020

gccuggcggc gcuggcucag ccgcggcgca cgucucggcg cgcuuccccu acucucccag     1080

cccgcccaug gccaacggcg ccgcgcggga gccgggaggc uacgcggcgg cgggcagugg     1140

gggcgcggga ggcgugagcg gcggcggcag uagccuggcg gccaugggcg gccgcgagcc     1200

ccaguacagc ucgcugucgg ccgcgcggcc gcugaacggg acguaccacc accaccacca     1260

ccaccaccac caccauccga gccccuacuc gcccuacgug ggggcgccac ugacgccugc     1320

cuggcccgcc ggacccuucg agaccccggu gcugcacagc cugcagagcc gcgccggagc     1380

cccgcucccg gugccccggg gucccagugc agaccugcug gaggaccugu ccgagagccg     1440

cgagugcgug aacugcggcu ccauccagac gccgcugugg cggcgggacg gcaccggcca     1500

cuaccugugc aacgccugcg ggcucuacag caagaugaac ggccucagcc ggccccucau     1560

caagccgcag aagcgcgugc cuucaucacg gcggcuugga uuguccugug ccaacuguca     1620

caccacaacu accaccuuau ggcgcagaaa cgccgagggu gaacccgugu gcaaugcuug     1680

uggacucuac augaaacucc auggggugcc cagaccacuu gcuaugaaaa aagagggaau     1740

ucaaaccagg aaacgaaaac cuaagaacau aaauaaauca aagacuugcu cugguaauag     1800

caauaauucc auucccauga cuccaacuuc caccucuucu aacucagaug auugcagcaa     1860

aaauacuucc cccacaacac aaccuacagc cucaggggcg ggugccccgg ugaugacugg     1920

ugcgggagag agcaccaauc ccgagaacag cgagcucaag uauucggguc aagaugggcu     1980

cuacauaggc gucagucucg ccucgccggc cgaagucacg uccuccgugc gaccggauuc     2040

cuggugcgcc cuggcccugg ccugagccca cgccgccagg aggcagggag ggcuccgccg     2100

cgggccucac uccacucgug ucugcuuuug ugcagcgguc cagacagugg cgacugcgcu     2160

gacagaacgu gauucucgug ccuuuauuuu gaaagagaug uuuuucccaa gaggcuugcu     2220

gaaagaguga gagaagaugg aagggaaggg ccagugcaac ugggcgcuug ggccacucca     2280

gccagcccgc cuccggggcg gacccugcuc cacuuccaga agccaggacu aggaccuggg     2340

ccuugccugc uauggaauau ugagagagau uuuuuaaaaa agauuuugca uuuuguccaa     2400

aaucaugugc uucuucugau caauuuuggu uguuccagaa uuucuucaua ccuuuuccac     2460

auccagauuu caugugcguu cauggagaag aucacuugag gccauuuggu acacaucucu     2520

ggaggcugag ucgguucaug aggucucuua ucaaaaauau uacucaguuu gcaagacugc     2580

auuguaacuu uaacauacac ugugacugac guuucucaaa guucauauug uguggcugau     2640

cugaagucag ucggaauuug uaaacagggu agcaaacaag auauuuuucu uccauguaua     2700

caauaauuuu uuuaaaaagu gcaauuugcg uugcagcaau caguguuaaa ucauuugcau     2760

aagauuuaac agcauuuuuu auaaugaaug uaaacauuuu aacuuaaugg uacuuaaaau     2820

aauuuaaaag aaaaauguua acuuagacau ucuuaugcuu cuuuuacaac uacaucccau     2880

uuuauauuuc caauuguuaa agaaaaauau uucaagaaca aaucuucucu caggaaaauu     2940

gccuuucucu auuuguuaag aauuuuuaua caagaacacc aauauacccc cuuuauuuua     3000

cuguggaaua ugugcuggaa aaauugcaac aacacuuuac uaccuaacgg auagcauuug     3060

uaaauacucu agguaucugu aaacacucug augaagucug uauaguguga cuaacccaca     3120

ggcagguugg uuuacauuaa uuuuuuuuuu ugaaugggau guccuaugga aaccuauuuc     3180

accagaguuu uaaaaauaaa aaggguauug uuuugucuuc uguacaguga guuccuuccc     3240

uuuucaaagc uuucuuuuua ugcuguaugu gacuauagau auucauauaa aacaagugca     3300

cgugaaguuu gcaaaaugcu uuaaggccuu ccuuucaaag cauaguccuu uuggagccgu     3360

uuuguaccuu uuauaccuug gcuuauuuga aguugacaca ugggguuagu uacuacucuc     3420

caugugcauu ggggacaguu uuuauaagug ggaaggacuc aguauuauua uauuugagau     3480

gauaagcauu uuguuuggga acaaugcuua aaaauauucc agaaaguuca gauuuuuuuu     3540

cuuugugaau gaaauauauu cuggcccacg aacagggcga uuuccuuuca guuuuuuccu     3600

uuugcaacgu gccuugaagu cucaaagcuc accugagguu gcagacguua cccccaacag     3660

aagauaggua gaaaugauuc caguggccuc uuuguauuuu cuucauuguu gaguagauuu     3720

caggaaauca ggagguguuu cacaauacag aaugauggcc uuuaacugug                3770


<210> 2
<211> 2352
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2352
<223> /mol_type="unassigned RNA"
      /note="Nkx2-1-Em"
      /organism="Homo sapiens"

<400> 2
gaaacuuaaa gguguuuacc uugucaucag cauguaagcu aauuaucucg ggcaagaugu      60

aggcuucuau ugucuuguug cuuuagcgcu uacgccccgc cucugguggc ugccuaaaac     120

cuggcgccgg gcuaaaacaa acgcgaggca gcccccgagc cuccacucaa gccaauuaag     180

gaggacucgg uccacuccgu uacguguaca uccaacaaga ucggcguuaa gguaacacca     240

gaauauuugg caaagggaga aaaaaaaagc agcgaggcuu cgccuucccc cucucccuuu     300

uuuuuccucc ucuuccuucc uccuccagcc gccgccgaau caugucgaug aguccaaagc     360

acacgacucc guucucagug ucugacaucu ugaguccccu ggaggaaagc uacaagaaag     420

ugggcaugga gggcggcggc cucggggcuc cgcuggcggc guacaggcag ggccaggcgg     480

caccgccaac agcggccaug cagcagcacg ccguggggca ccacggcgcc gucaccgccg     540

ccuaccacau gacggcggcg ggggugcccc agcucucgca cuccgccgug gggggcuacu     600

gcaacggcaa ccugggcaac augagcgagc ugccgccgua ccaggacacc augaggaaca     660

gcgccucugg ccccggaugg uacggcgcca acccagaccc gcgcuucccc gccaucuccc     720

gcuucauggg cccggcgagc ggcaugaaca ugagcggcau gggcggccug ggcucgcugg     780

gggacgugag caagaacaug gccccgcugc caagcgcgcc gcgcaggaag cgccgggugc     840

ucuucucgca ggcgcaggug uacgagcugg agcgacgcuu caagcaacag aaguaccugu     900

cggcgccgga gcgcgagcac cuggccagca ugauccaccu gacgcccacg caggucaaga     960

ucugguucca gaaccaccgc uacaaaauga agcgccaggc caaggacaag gcggcgcagc    1020

agcaacugca gcaggacagc ggcggcggcg ggggcggcgg gggcaccggg ugcccgcagc    1080

agcaacaggc ucagcagcag ucgccgcgac gcguggcggu gccgguccug gugaaagacg    1140

gcaaaccgug ccaggcgggu gcccccgcgc cgggcgccgc cagccuacaa ggccacgcgc    1200

agcagcaggc gcagcaccag gcgcaggccg cgcaggcggc ggcagcggcc aucuccgugg    1260

gcagcggugg cgccggccuu ggcgcacacc cgggccacca gccaggcagc gcaggccagu    1320

cuccggaccu ggcgcaccac gccgccagcc ccgcggcgcu gcagggccag guauccagcc    1380

ugucccaccu gaacuccucg ggcucggacu acggcaccau guccugcucc accuugcuau    1440

acggucggac cuggugagag gacgccgggc cggcccuagc ccagcgcucu gccucaccgc    1500

uucccuccug cccgccacac agaccaccau ccaccgcugc uccacgcgcu ucgacuuuuc    1560

uuaacaaccu ggccgcguuu agaccaagga acaaaaaaac cacaaaggcc aaacugcugg    1620

acgucuuucu uuuuuucccc cccuaaaauu uguggguuuu uuuuuuuaaa aaaagaaaau    1680

gaaaaacaac caagcgcauc caaucucaag gaaucuuuaa gcagagaagg gcauaaaaca    1740

gcuuuggggu gucuuuuuuu ggugauucaa auggguuuuc cacgcuaggg cggggcacag    1800

auuggagagg gcucugugcu gacauggcuc uggacucuaa agaccaaacu ucacucuggg    1860

cacacucugc cagcaaagag gacucgcuug uaaauaccag gauuuuuuuu uuuuuuugaa    1920

gggaggacgg gagcugggga gaggaaagag ucuucaacau aacccacuug ucacugacac    1980

aaaggaagug cccccucccc ggcacccucu ggccgccuag gcucagcggc gaccgcccuc    2040

cgcgaaaaua guuuguuuaa ugugaacuug uagcuguaaa acgcugucaa aaguuggacu    2100

aaaugccuag uuuuuaguaa ucuguacauu uuguuguaaa aagaaaaacc acucccaguc    2160

cccagcccuu cacauuuuuu augggcauug acaaaucugu guauauuauu uggcaguuug    2220

guauuugcgg cgucagucuu uuucuguugu aacuuaugua gauauuuggc uuaaauauag    2280

uuccuaagaa gcuucuaaua aauuauacaa auuaaaaaga uucuuuuucu gauuaaaaaa    2340

aaaaaaaaaa aa                                                        2352


<210> 3
<211> 2428
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2428
<223> /mol_type="unassigned RNA"
      /note="Foxa2-Em"
      /organism="Homo sapiens"

<400> 3
cccgcccacu uccaacuacc gccuccggcc ugcccaggga gagagaggga guggagccca      60

gggagaggga gcgcgagaga gggagggagg aggggacggu gcuuuggcug acuuuuuuuu     120

aaaagagggu gggggugggg ggugauugcu ggucguuugu uguggcuguu aaauuuuaaa     180

cugccaugca cucggcuucc aguaugcugg gagcggugaa gauggaaggg cacgagccgu     240

ccgacuggag cagcuacuau gcagagcccg agggcuacuc cuccgugagc aacaugaacg     300

ccggccuggg gaugaacggc augaacacgu acaugagcau gucggcggcc gccaugggca     360

gcggcucggg caacaugagc gcgggcucca ugaacauguc gucguacgug ggcgcuggca     420

ugagcccguc ccuggcgggg augucccccg gcgcgggcgc cauggcgggc augggcggcu     480

cggccggggc ggccggcgug gcgggcaugg ggccgcacuu gagucccagc cugagcccgc     540

ucggggggca ggcggccggg gccaugggcg gccuggcccc cuacgccaac augaacucca     600

ugagccccau guacgggcag gcgggccuga gccgcgcccg cgaccccaag accuacaggc     660

gcagcuacac gcacgcaaag ccgcccuacu cguacaucuc gcucaucacc auggccaucc     720

agcagagccc caacaagaug cugacgcuga gcgagaucua ccaguggauc auggaccucu     780

uccccuucua ccggcagaac cagcagcgcu ggcagaacuc cauccgccac ucgcucuccu     840

ucaacgacug uuuccugaag gugccccgcu cgcccgacaa gcccggcaag ggcuccuucu     900

ggacccugca cccugacucg ggcaacaugu ucgagaacgg cugcuaccug cgccgccaga     960

agcgcuucaa gugcgagaag cagcuggcgc ugaaggaggc cgcaggcgcc gccggcagcg    1020

gcaagaaggc ggccgccgga gcccaggccu cacaggcuca acucggggag gccgccgggc    1080

cggccuccga gacuccggcg ggcaccgagu cgccucacuc gagcgccucc ccgugccagg    1140

agcacaagcg agggggccug ggagagcuga aggggacgcc ggcugcggcg cugagccccc    1200

cagagccggc gcccucuccc gggcagcagc agcaggccgc ggcccaccug cugggcccgc    1260

cccaccaccc gggccugccg ccugaggccc accugaagcc ggaacaccac uacgccuuca    1320

accacccguu cuccaucaac aaccucaugu ccucggagca gcagcaccac cacagccacc    1380

accaccacca accccacaaa auggaccuca aggccuacga acaggugaug cacuaccccg    1440

gcuacgguuc ccccaugccu ggcagcuugg ccaugggccc ggucacgaac aaaacgggcc    1500

uggacgccuc gccccuggcc gcagauaccu ccuacuacca ggggguguac ucccggccca    1560

uuaugaacuc cucuuaagaa gacgacggcu ucaggcccgg cuaacucugg caccccggau    1620

cgaggacaag ugagagagca aguggggguc gagacuuugg ggagacggug uugcagagac    1680

gcaagggaga agaaauccau aacaccccca ccccaacacc cccaagacag cagucuucuu    1740

cacccgcugc agccguuccg ucccaaacag agggccacac agauacccca cguucuauau    1800

aaggaggaaa acgggaaaga auauaaaguu aaaaaaaagc cuccgguuuc cacuacugug    1860

uagacuccug cuucuucaag caccugcaga uucugauuuu uuuguuguug uuguucuccu    1920

ccauugcugu uguugcaggg aagucuuacu uaaaaaaaaa aaaaaauuuu gugagugacu    1980

cgguguaaaa ccauguaguu uuaacagaac cagaggguug uacuauuguu uaaaaacagg    2040

aaaaaaaaua auguaagggu cuguuguaaa ugaccaagaa aaagaaaaaa aaagcauucc    2100

caaucuugac acggugaaau ccaggucucg gguccgauua auuuaugguu ucugcgugcu    2160

uuauuuaugg cuuauaaaug uguauucugg cugcaagggc cagaguucca caaaucuaua    2220

uuaaaguguu auacccgguu uuaucccuug aaucuuuucu uccagauuuu ucuuuucuuu    2280

acuuggcuua caaaauauac aggcuuggaa auuauuucaa gaaggaggga gggauacccu    2340

gucugguugc agguuguauu uuauuuuggc ccagggagug uugcuguuuu cccaacauuu    2400

uauuaauaaa auuuucagac auaaaaaa                                       2428


<210> 4
<211> 1402
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1402
<223> /mol_type="unassigned RNA"
      /note="Id2-Em"
      /organism="Homo sapiens"

<400> 4
ggggacgaag ggaagcucca gcguguggcc ccggcgagug cggauaaaag ccgccccgcc      60

gggcucgggc uucauucuga gccgagcccg gugccaagcg cagcuagcuc agcaggcggc     120

agcggcggcc ugagcuucag ggcagccagc ucccucccgg ucucgccuuc ccucgcgguc     180

agcaugaaag ccuucagucc cgugaggucc guuaggaaaa acagccuguc ggaccacagc     240

cugggcaucu cccggagcaa aaccccugug gacgacccga ugagccugcu auacaacaug     300

aacgacugcu acuccaagcu caaggagcug gugcccagca ucccccagaa caagaaggug     360

agcaagaugg aaauccugca gcacgucauc gacuacaucu uggaccugca gaucgcccug     420

gacucgcauc ccacuauugu cagccugcau caccagagac ccgggcagaa ccaggcgucc     480

aggacgccgc ugaccacccu caacacggau aucagcaucc uguccuugca ggcuucugaa     540

uucccuucug aguuaauguc aaaugacagc aaagcacugu guggcugaau aagcgguguu     600

caugauuucu uuuauucuuu gcacaacaac aacaacaaca aauucacgga aucuuuuaag     660

ugcugaacuu auuuuucaac cauuucacaa ggaggacaag uugaauggac cuuuuuaaaa     720

agaaaaaaaa aauggaagga aaacuaagaa ugaucaucuu cccagggugu ucucuuacuu     780

ggacugugau auucguuauu uaugaaaaag acuuuuaaau gcccuuucug caguuggaag     840

guuuucuuua uauacuauuc ccaccauggg gagcgaaaac guuaaaauca caaggaauug     900

cccaaucuaa gcagacuuug ccuuuuuuca aagguggagc gugaauacca gaaggaucca     960

guauucaguc acuuaaauga agucuuuugg ucagaaauua ccuuuuugac acaagccuac    1020

ugaaugcugu guauauauuu auauauaaau auaucuauuu gagugaaacc uugugaacuc    1080

uuuaauuaga guuuucuugu auaguggcag agaugucuau uucugcauuc aaaaguguaa    1140

ugauguacuu auucaugcua aacuuuuuau aaaaguuuag uuguaaacuu aacccuuuua    1200

uacaaaauaa aucaagugug uuuauugaau ggugauugcc ugcuuuauuu cagaggacca    1260

gugcuuugau uuuuauuaug cuauguuaua acugaaccca aauaaauaca aguucaaauu    1320

uauguagacu guauaagauu auaauaaaac augucugaag ucaaaaaaaa aaaaaaaaaa    1380

aaaaaaaaaa aaaaaaaaaa aa                                             1402


<210> 5
<211> 3158
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3158
<223> /mol_type="unassigned RNA"
      /note="Gata6-Ad"
      /organism="Homo sapiens"

<400> 5
auugaucucc acgcccgggg cagaaauagg aucuuugaga agucucaaau gggaucuuug      60

agaagucaga ucccauuuga acuagaaaaa ggaguggagg cgagguagcg ugcagccuac     120

gcucuuguua acccgucgau cuccuaccau acccgucucc cccaccccac cucaggagcu     180

agacgucagc uuggagcggc gccggaccgu ggauggccuu gacugacggc ggcuggugcu     240

ugccgaagcg cuucggggcc gcgggugcgg acgccagcga cuccagagcc uuuccagcgc     300

gggagcccuc cacgccgccu ucccccaucu cuuccucguc cuccuccugc ucccggggcg     360

gagagcgggg ccccggcggc gccagcaacu gcgggacgcc ucagcucgac acggaggcgg     420

cggccggacc cccggcccgc ucgcugcugc ucaguuccua cgcuucgcau cccuucgggg     480

cuccccacgg accuucggcg ccuggggucg cgggccccgg gggcaaccug ucgagcuggg     540

aggacuugcu gcuguucacu gaccucgacc aagccgcgac cgccagcaag cugcuguggu     600

ccagccgcgg cgccaagcug agccccuucg cacccgagca gccggaggag auguaccaga     660

cccucgccgc ucucuccagc caggguccgg ccgccuacga cggcgcgccc ggcggcuucg     720

ugcacucugc ggccgcggcg gcagcagccg cggcggcggc cagcuccccg gucuacgugc     780

ccaccacccg cguggguucc augcugcccg gccuaccgua ccaccugcag gggucgggca     840

gugggccagc caaccacgcg ggcggcgcgg gcgcgcaccc cggcuggccu caggccucgg     900

ccgacagccc uccauacggc agcggaggcg gcgcggcugg cggcggggcc gcggggccug     960

gcggcgcugg cucagccgcg gcgcacgucu cggcgcgcuu ccccuacucu cccagcccgc    1020

ccauggccaa cggcgccgcg cgggagccgg gaggcuacgc ggcggcgggc agugggggcg    1080

cgggaggcgu gagcggcggc ggcaguagcc uggcggccau gggcggccgc gagccccagu    1140

acagcucgcu gucggccgcg cggccgcuga acgggacgua ccaccaccac caccaccacc    1200

accaccacca uccgagcccc uacucgcccu acgugggggc gccacugacg ccugccuggc    1260

ccgccggacc cuucgagacc ccggugcugc acagccugca gagccgcgcc ggagccccgc    1320

ucccggugcc ccgggguccc agugcagacc ugcuggagga ccuguccgag agccgcgagu    1380

gcgugaacug cggcuccauc cagacgccgc uguggcggcg ggacggcacc ggccacuacc    1440

ugugcaacgc cugcgggcuc uacagcaaga ugaacggccu cagccggccc cucaucaagc    1500

cgcagaagcg cgugccuuca ucacggcggc uuggauuguc cugugccaac ugucacacca    1560

caacuaccac cuuauggcgc agaaacgccg agggugaacc cgugugcaau gcuuguggac    1620

ucuacaugaa acuccauggg gugcccagac cacuugcuau gaaaaaagag ggaauucaaa    1680

ccaggaaacg aaaaccuaag aacauaaaua aaucaaagac uugcucuggu aauagcaaua    1740

auuccauucc caugacucca acuuccaccu cuucuaacuc agaugauugc agcaaaaaua    1800

cuucccccac aacacaaccu acagccucag gggcgggugc cccggugaug acuggugcgg    1860

gagagagcac caaucccgag aacagcgagc ucaaguauuc gggucaagau gggcucuaca    1920

uaggcgucag ucucgccucg ccggccgaag ucacguccuc cgugcgaccg gauuccuggu    1980

gcgcccuggc ccuggccuga gcccacgccg ccaggaggca gggagggcuc cgccgcgggc    2040

cucacuccac ucgugucugc uuuugugcag cgguccagac aguggcgacu gcgcugacag    2100

aacgugauuc ucgugccuuu auuuugaaag agauguuuuu cccaagaggc uugcugaaag    2160

agugagagaa gauggaaggg aagggccagu gcaacugggc gcuugggcca cuccagccag    2220

cccgccuccg gggcggaccc ugcuccacuu ccagaagcca ggacuaggac cugggccuug    2280

ccugcuaugg aauauugaga gagauuuuuu aaaaaagauu uugcauuuug uccaaaauca    2340

ugugcuucuu cugaucaauu uugguuguuc cagaauuucu ucauaccuuu uccacaucca    2400

gauuucaugu gcguucaugg agaagaucac uugaggccau uugguacaca ucucuggagg    2460

cugagucggu ucaugagguc ucuuaucaaa aauauuacuc aguuugcaag acugcauugu    2520

aacuuuaaca uacacuguga cugacguuuc ucaaaguuca uauugugugg cugaucugaa    2580

gucagucgga auuuguaaac aggguagcaa acaagauauu uuucuuccau guauacaaua    2640

auuuuuuuaa aaagugcaau uugcguugca gcaaucagug uuaaaucauu ugcauaagau    2700

uuaacagcau uuuuuauaau gaauguaaac auuuuaacuu aaugguacuu aaaauaauuu    2760

aaaagaaaaa uguuaacuua gacauucuua ugcuucuuuu acaacuacau cccauuuuau    2820

auuuccaauu guuaaagaaa aauauuucaa gaacaaaucu ucucucagga aaauugccuu    2880

ucucuauuug uuaagaauuu uuauacaaga acaccaauau acccccuuua uuuuacugug    2940

gaauaugugc uggaaaaauu gcaacaacac uuuacuaccu aacggauagc auuuguaaau    3000

acucuaggua ucuguaaaca cucugaugaa gucuguauag ugugacuaac ccacaggcag    3060

guugguuuac auuaauuuuu uuuuuugaau gggauguccu auggaaaccu auuucaccag    3120

aguuuuaaaa auaaaaaggg uauuguuuug ucuucugu                            3158


<210> 6
<211> 2197
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2197
<223> /mol_type="unassigned RNA"
      /note="Nkx2-1-Ad"
      /organism="Homo sapiens"

<400> 6
cugacagaca cguagaccaa cagugcggcc ccaggguucg uccccagacu cgcucgcuca      60

uuuguuggcg acuggggcuc agcgcagcga agcccgaugu gguccggagg cagugggaag     120

gcgcggggcu gggaggccgc ggcgggaggg aggagcagcc ccggcaggcu cagccgccgc     180

cgaaucaugu cgaugagucc aaagcacacg acuccguucu cagugucuga caucuugagu     240

ccccuggagg aaagcuacaa gaaagugggc auggagggcg gcggccucgg ggcuccgcug     300

gcggcguaca ggcagggcca ggcggcaccg ccaacagcgg ccaugcagca gcacgccgug     360

gggcaccacg gcgccgucac cgccgccuac cacaugacgg cggcgggggu gccccagcuc     420

ucgcacuccg ccgugggggg cuacugcaac ggcaaccugg gcaacaugag cgagcugccg     480

ccguaccagg acaccaugag gaacagcgcc ucuggccccg gaugguacgg cgccaaccca     540

gacccgcgcu uccccgccau cucccgcuuc augggcccgg cgagcggcau gaacaugagc     600

ggcaugggcg gccugggcuc gcugggggac gugagcaaga acauggcccc gcugccaagc     660

gcgccgcgca ggaagcgccg ggugcucuuc ucgcaggcgc agguguacga gcuggagcga     720

cgcuucaagc aacagaagua ccugucggcg ccggagcgcg agcaccuggc cagcaugauc     780

caccugacgc ccacgcaggu caagaucugg uuccagaacc accgcuacaa aaugaagcgc     840

caggccaagg acaaggcggc gcagcagcaa cugcagcagg acagcggcgg cggcgggggc     900

ggcgggggca ccgggugccc gcagcagcaa caggcucagc agcagucgcc gcgacgcgug     960

gcggugccgg uccuggugaa agacggcaaa ccgugccagg cgggugcccc cgcgccgggc    1020

gccgccagcc uacaaggcca cgcgcagcag caggcgcagc accaggcgca ggccgcgcag    1080

gcggcggcag cggccaucuc cgugggcagc gguggcgccg gccuuggcgc acacccgggc    1140

caccagccag gcagcgcagg ccagucuccg gaccuggcgc accacgccgc cagccccgcg    1200

gcgcugcagg gccagguauc cagccugucc caccugaacu ccucgggcuc ggacuacggc    1260

accauguccu gcuccaccuu gcuauacggu cggaccuggu gagaggacgc cgggccggcc    1320

cuagcccagc gcucugccuc accgcuuccc uccugcccgc cacacagacc accauccacc    1380

gcugcuccac gcgcuucgac uuuucuuaac aaccuggccg cguuuagacc aaggaacaaa    1440

aaaaccacaa aggccaaacu gcuggacguc uuucuuuuuu ucccccccua aaauuugugg    1500

guuuuuuuuu uuaaaaaaag aaaaugaaaa acaaccaagc gcauccaauc ucaaggaauc    1560

uuuaagcaga gaagggcaua aaacagcuuu ggggugucuu uuuuugguga uucaaauggg    1620

uuuuccacgc uagggcgggg cacagauugg agagggcucu gugcugacau ggcucuggac    1680

ucuaaagacc aaacuucacu cugggcacac ucugccagca aagaggacuc gcuuguaaau    1740

accaggauuu uuuuuuuuuu uugaagggag gacgggagcu ggggagagga aagagucuuc    1800

aacauaaccc acuugucacu gacacaaagg aagugccccc uccccggcac ccucuggccg    1860

ccuaggcuca gcggcgaccg cccuccgcga aaauaguuug uuuaauguga acuuguagcu    1920

guaaaacgcu gucaaaaguu ggacuaaaug ccuaguuuuu aguaaucugu acauuuuguu    1980

guaaaaagaa aaaccacucc caguccccag cccuucacau uuuuuauggg cauugacaaa    2040

ucuguguaua uuauuuggca guuugguauu ugcggcguca gucuuuuucu guuguaacuu    2100

auguagauau uuggcuuaaa uauaguuccu aagaagcuuc uaauaaauua uacaaauuaa    2160

aaagauucuu uuucugauua aaaaaaaaaa aaaaaaa                             2197


<210> 7
<211> 2415
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2415
<223> /mol_type="unassigned RNA"
      /note="Foxa2-Ad"
      /organism="Homo sapiens"

<400> 7
cggccgcugc uagaggggcu gcuugcgcca ggcgccggcc gccccacugc gggucccugg      60

cggccggugu cugaggaguc ggagagccga ggcggccaga ccgugcgccc cgcgcuucuc     120

ccgaggccgu uccgggucug aacuguaaca gggaggggcc ucgcaggagc agcagcgggc     180

gaguuaaagu augcugggag cggugaagau ggaagggcac gagccguccg acuggagcag     240

cuacuaugca gagcccgagg gcuacuccuc cgugagcaac augaacgccg gccuggggau     300

gaacggcaug aacacguaca ugagcauguc ggcggccgcc augggcagcg gcucgggcaa     360

caugagcgcg ggcuccauga acaugucguc guacgugggc gcuggcauga gcccgucccu     420

ggcggggaug ucccccggcg cgggcgccau ggcgggcaug ggcggcucgg ccggggcggc     480

cggcguggcg ggcauggggc cgcacuugag ucccagccug agcccgcucg gggggcaggc     540

ggccggggcc augggcggcc uggcccccua cgccaacaug aacuccauga gccccaugua     600

cgggcaggcg ggccugagcc gcgcccgcga ccccaagacc uacaggcgca gcuacacgca     660

cgcaaagccg cccuacucgu acaucucgcu caucaccaug gccauccagc agagccccaa     720

caagaugcug acgcugagcg agaucuacca guggaucaug gaccucuucc ccuucuaccg     780

gcagaaccag cagcgcuggc agaacuccau ccgccacucg cucuccuuca acgacuguuu     840

ccugaaggug ccccgcucgc ccgacaagcc cggcaagggc uccuucugga cccugcaccc     900

ugacucgggc aacauguucg agaacggcug cuaccugcgc cgccagaagc gcuucaagug     960

cgagaagcag cuggcgcuga aggaggccgc aggcgccgcc ggcagcggca agaaggcggc    1020

cgccggagcc caggccucac aggcucaacu cggggaggcc gccgggccgg ccuccgagac    1080

uccggcgggc accgagucgc cucacucgag cgccuccccg ugccaggagc acaagcgagg    1140

gggccuggga gagcugaagg ggacgccggc ugcggcgcug agccccccag agccggcgcc    1200

cucucccggg cagcagcagc aggccgcggc ccaccugcug ggcccgcccc accacccggg    1260

ccugccgccu gaggcccacc ugaagccgga acaccacuac gccuucaacc acccguucuc    1320

caucaacaac cucauguccu cggagcagca gcaccaccac agccaccacc accaccaacc    1380

ccacaaaaug gaccucaagg ccuacgaaca ggugaugcac uaccccggcu acgguucccc    1440

caugccuggc agcuuggcca ugggcccggu cacgaacaaa acgggccugg acgccucgcc    1500

ccuggccgca gauaccuccu acuaccaggg gguguacucc cggcccauua ugaacuccuc    1560

uuaagaagac gacggcuuca ggcccggcua acucuggcac cccggaucga ggacaaguga    1620

gagagcaagu gggggucgag acuuugggga gacgguguug cagagacgca agggagaaga    1680

aauccauaac acccccaccc caacaccccc aagacagcag ucuucuucac ccgcugcagc    1740

cguuccgucc caaacagagg gccacacaga uaccccacgu ucuauauaag gaggaaaacg    1800

ggaaagaaua uaaaguuaaa aaaaagccuc cgguuuccac uacuguguag acuccugcuu    1860

cuucaagcac cugcagauuc ugauuuuuuu guuguuguug uucuccucca uugcuguugu    1920

ugcagggaag ucuuacuuaa aaaaaaaaaa aaauuuugug agugacucgg uguaaaacca    1980

uguaguuuua acagaaccag aggguuguac uauuguuuaa aaacaggaaa aaaaauaaug    2040

uaagggucug uuguaaauga ccaagaaaaa gaaaaaaaaa gcauucccaa ucuugacacg    2100

gugaaaucca ggucucgggu ccgauuaauu uaugguuucu gcgugcuuua uuuauggcuu    2160

auaaaugugu auucuggcug caagggccag aguuccacaa aucuauauua aaguguuaua    2220

cccgguuuua ucccuugaau cuuuucuucc agauuuuucu uuucuuuacu uggcuuacaa    2280

aauauacagg cuuggaaauu auuucaagaa ggagggaggg auacccuguc ugguugcagg    2340

uuguauuuua uuuuggccca gggaguguug cuguuuuccc aacauuuuau uaauaaaauu    2400

uucagacaua aaaaa                                                     2415


<210> 8
<211> 1681
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1681
<223> /mol_type="unassigned RNA"
      /note="Id2-Ad"
      /organism="Homo sapiens"

<400> 8
caaaggcggc cuggccagcg cggagcuccc ggcccggagc ugcuucugau uaccgcgagg      60

ggcccggacg cgagagccgc cgcggggccu gcccuagagg cggagugaug aacuguggcu     120

uccccccugc ggugcugaac ucgcccgugu agcugugauu uuagagcugc cgacagcucu     180

aagcugggcu cgcgccccgc ccaccccgcg gggauuggcu gcgaacgcgg aagaaccaag     240

cccacgcccc gcgcccgcgc ccaccaaugg aagcgcccgc ucgucuugau agacgugcca     300

ccuuccgcca auggggacga agggaagcuc cagcgugugg ccccggcgag ugcggauaaa     360

agccgccccg ccgggcucgg gcuucauucu gagccgagcc cggugccaag cgcagcuagc     420

ucagcaggcg gcagcggcgg ccugagcuuc agggcagcca gcucccuccc ggucucgccu     480

ucccucgcgg ucagcaugaa agccuucagu cccgugaggu ccguuaggaa aaacagccug     540

ucggaccaca gccugggcau cucccggagc aaaaccccug uggacgaccc gaugagccug     600

cuauacaaca ugaacgacug cuacuccaag cucaaggagc uggugcccag caucccccag     660

aacaagaagg ugagcaagau ggaaauccug cagcacguca ucgacuacau cuuggaccug     720

cagaucgccc uggacucgca ucccacuauu gucagccugc aucaccagag acccgggcag     780

aaccaggcgu ccaggacgcc gcugaccacc cucaacacgg auaucagcau ccuguccuug     840

caggcuucug aauucccuuc ugaguuaaug ucaaaugaca gcaaagcacu guguggcuga     900

auaagcggug uucaugauuu cuuuuauucu uugcacaaca acaacaacaa caaauucacg     960

gaaucuuuua agugcugaac uuauuuuuca accauuucac aaggaggaca aguugaaugg    1020

accuuuuuaa aaagaaaaaa aaaauggaag gaaaacuaag aaugaucauc uucccagggu    1080

guucucuuac uuggacugug auauucguua uuuaugaaaa agacuuuuaa augcccuuuc    1140

ugcaguugga agguuuucuu uauauacuau ucccaccaug gggagcgaaa acguuaaaau    1200

cacaaggaau ugcccaaucu aagcagacuu ugccuuuuuu caaaggugga gcgugaauac    1260

cagaaggauc caguauucag ucacuuaaau gaagucuuuu ggucagaaau uaccuuuuug    1320

acacaagccu acugaaugcu guguauauau uuauauauaa auauaucuau uugagugaaa    1380

ccuugugaac ucuuuaauua gaguuuucuu guauaguggc agagaugucu auuucugcau    1440

ucaaaagugu aaugauguac uuauucaugc uaaacuuuuu auaaaaguuu aguuguaaac    1500

uuaacccuuu uauacaaaau aaaucaagug uguuuauuga auggugauug ccugcuuuau    1560

uucagaggac cagugcuuug auuuuuauua ugcuauguua uaacugaacc caaauaaaua    1620

caaguucaaa uuuauguaga cuguauaaga uuauaauaaa acaugucuga agucaauacc    1680

u                                                                    1681


<210> 9
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Gata6-Em Fwd"
      /organism="Artificial Sequence"

<400> 9
ctcggcttct ctccgcgcct g                                              21


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Gata6-Em Fwd"
      /organism="Artificial Sequence"

<400> 10
ttgactgacg gcggctggtg                                                20


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Gata6-Em Rev"
      /organism="Artificial Sequence"

<400> 11
agctgaggcg tcccgcagtt g                                              21


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Gata6-Em Rev"
      /organism="Artificial Sequence"

<400> 12
ctcccgcgct ggaaaggctc                                                20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Gata6-Ad Fwd"
      /organism="Artificial Sequence"

<400> 13
gcggtttcgt tttcggggac                                                20


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Gata6-Ad Fwd"
      /organism="Artificial Sequence"

<400> 14
aggacccaga ctgctgcccc                                                20


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Gata6-Ad Rev"
      /organism="Artificial Sequence"

<400> 15
aagggatgcg aagcgtagga                                                20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Gata6-Ad Rev"
      /organism="Artificial Sequence"

<400> 16
ctgaccagcc cgaacgcgag                                                20


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Nkx2-1-Em Fwd"
      /organism="Artificial Sequence"

<400> 17
aaacctggcg ccgggctaaa                                                20


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Nkx2-1-Em Fwd"
      /organism="Artificial Sequence"

<400> 18
cagcgaggct tcgccttccc                                                20


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Nkx2-1-Em Rev"
      /organism="Artificial Sequence"

<400> 19
ggagaggggg aaggcgaagc c                                              21


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Nkx2-1-Em Rev"
      /organism="Artificial Sequence"

<400> 20
tcgacatgat tcggcggcgg                                                20


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Nkx2-1-Ad Fwd"
      /organism="Artificial Sequence"

<400> 21
agcgaagccc gatgtggtcc                                                20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Nkx2-1-Ad Fwd"
      /organism="Artificial Sequence"

<400> 22
tccggaggca gtgggaaggc                                                20


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Nk2-1-Ad Rev"
      /organism="Artificial Sequence"

<400> 23
ccgccctcca tgcccacttt c                                              21


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Nk2-1-Ad Rev"
      /organism="Artificial Sequence"

<400> 24
gacatgattc ggcggcggct                                                20


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Foxa2-Em Fwd"
      /organism="Artificial Sequence"

<400> 25
tgccatgcac tcggcttcca g                                              21


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Foxa2-Em Fwd"
      /organism="Artificial Sequence"

<400> 26
cagggagagg gagggcgaga                                                20


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Foxa2-Em Rev"
      /organism="Artificial Sequence"

<400> 27
tcatgttgcc cgagccgctg                                                20


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Foxa2-Em Rev"
      /organism="Artificial Sequence"

<400> 28
cccccacccc caccctcttt                                                20


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Foxa2-Ad Fwd"
      /organism="Artificial Sequence"

<400> 29
ctgctagagg ggctgcttgc g                                              21


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Foxa2-Ad Fwd"
      /organism="Artificial Sequence"

<400> 30
cgcttctccc gaggccgttc                                                20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Foxa2-Ad Rev"
      /organism="Artificial Sequence"

<400> 31
acggctcgtg cccttccatc                                                20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Foxa2-Ad Rev"
      /organism="Artificial Sequence"

<400> 32
taactcgccc gctgctgctc                                                20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Id2-Em Fwd"
      /organism="Artificial Sequence"

<400> 33
aacccctgtg gacgacccga                                                20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Id2-Em Fwd"
      /organism="Artificial Sequence"

<400> 34
tgcggataaa agccgccccg                                                20


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Id2-Em Rev"
      /organism="Artificial Sequence"

<400> 35
gcccgggtct ctggtgatgc                                                20


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Id2-Em Rev"
      /organism="Artificial Sequence"

<400> 36
agctagctgc gcttggcacc                                                20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Id2-Ad Fwd"
      /organism="Artificial Sequence"

<400> 37
ctgcggtgct gaactcgccc                                                20


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Id2-Ad Fwd"
      /organism="Artificial Sequence"

<400> 38
ccccctgcgg tgctgaactc                                                20


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Id2-Ad Rev"
      /organism="Artificial Sequence"

<400> 39
gacgagcggg cgcttccatt                                                20


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Id2-Ad Rev"
      /organism="Artificial Sequence"

<400> 40
taactcgccc gctgctgctc                                                20


<210> 41
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned RNA"
      /note="Gata6-Em sense siRNA "
      /organism="Artificial Sequence"

<400> 41
ucaggagcgc aggcugcagt t                                              21


<210> 42
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned RNA"
      /note="Gata6-Em sense siRNA"
      /organism="Artificial Sequence"

<400> 42
gaggcgccuc cucucuccut t                                              21


<210> 43
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned RNA"
      /note="Gata6-Em antisense siRNA"
      /organism="Artificial Sequence"

<400> 43
cugcagccug cgcuccugat t                                              21


<210> 44
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned RNA"
      /note="Gata6-Em antisense siRNA"
      /organism="Artificial Sequence"

<400> 44
aggagagagg aggcgccuct t                                              21


<210> 45
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned RNA"
      /note="FoxA2-Em sense siRNA"
      /organism="Artificial Sequence"

<400> 45
accgccaugc acucggcuut t                                              21


<210> 46
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned RNA"
      /note="FoxA2-Em antisense siRNA"
      /organism="Artificial Sequence"

<400> 46
aagccgagug cauggcggut t                                              21


<210> 47
<211> 58
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..58
<223> /mol_type="unassigned RNA"
      /note="Nkx2-1-Em shRNA"
      /organism="Artificial Sequence"

<400> 47
ccggcccatg aagaagaaag caattctcga gaattgcttt cttcttcatg ggtttttg       58


<210> 48
<211> 62
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..62
<223> /mol_type="unassigned RNA"
      /note="Nkx2-1-Em shRNA"
      /organism="Artificial Sequence"

<400> 48
gtaccggggg atcatccttg tagataaact cgagtttatc tacaaggatg atcccttttt     60

tg                                                                    62


<210> 49
<211> 58
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..58
<223> /mol_type="unassigned RNA"
      /note="Nkx2-1-Em shRNA"
      /organism="Artificial Sequence"

<400> 49
ccggattcgg aatcagctag caattctcga gaattgctag ctgattccga attttttg       58


<210> 50
<211> 595
<212> PRT
<213> Homo sapiens

<220> 
<223> Gata6-Em

<400> 50
Met Ala Leu Thr Asp Gly Gly Trp Cys Leu Pro Lys Arg Phe Gly Ala 
1               5                   10                  15      
Ala Gly Ala Asp Ala Ser Asp Ser Arg Ala Phe Pro Ala Arg Glu Pro 
            20                  25                  30          
Ser Thr Pro Pro Ser Pro Ile Ser Ser Ser Ser Ser Ser Cys Ser Arg 
        35                  40                  45              
Gly Gly Glu Arg Gly Pro Gly Gly Ala Ser Asn Cys Gly Thr Pro Gln 
    50                  55                  60                  
Leu Asp Thr Glu Ala Ala Ala Gly Pro Pro Ala Arg Ser Leu Leu Leu 
65                  70                  75                  80  
Ser Ser Tyr Ala Ser His Pro Phe Gly Ala Pro His Gly Pro Ser Ala 
                85                  90                  95      
Pro Gly Val Ala Gly Pro Gly Gly Asn Leu Ser Ser Trp Glu Asp Leu 
            100                 105                 110         
Leu Leu Phe Thr Asp Leu Asp Gln Ala Ala Thr Ala Ser Lys Leu Leu 
        115                 120                 125             
Trp Ser Ser Arg Gly Ala Lys Leu Ser Pro Phe Ala Pro Glu Gln Pro 
    130                 135                 140                 
Glu Glu Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln Gly Pro Ala 
145                 150                 155                 160 
Ala Tyr Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala Ala Ala Ala 
                165                 170                 175     
Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val Pro Thr Thr 
            180                 185                 190         
Arg Val Gly Ser Met Leu Pro Gly Leu Pro Tyr His Leu Gln Gly Ser 
        195                 200                 205             
Gly Ser Gly Pro Ala Asn His Ala Gly Gly Ala Gly Ala His Pro Gly 
    210                 215                 220                 
Trp Pro Gln Ala Ser Ala Asp Ser Pro Pro Tyr Gly Ser Gly Gly Gly 
225                 230                 235                 240 
Ala Ala Gly Gly Gly Ala Ala Gly Pro Gly Gly Ala Gly Ser Ala Ala 
                245                 250                 255     
Ala His Val Ser Ala Arg Phe Pro Tyr Ser Pro Ser Pro Pro Met Ala 
            260                 265                 270         
Asn Gly Ala Ala Arg Glu Pro Gly Gly Tyr Ala Ala Ala Gly Ser Gly 
        275                 280                 285             
Gly Ala Gly Gly Val Ser Gly Gly Gly Ser Ser Leu Ala Ala Met Gly 
    290                 295                 300                 
Gly Arg Glu Pro Gln Tyr Ser Ser Leu Ser Ala Ala Arg Pro Leu Asn 
305                 310                 315                 320 
Gly Thr Tyr His His His His His His His His His His Pro Ser Pro 
                325                 330                 335     
Tyr Ser Pro Tyr Val Gly Ala Pro Leu Thr Pro Ala Trp Pro Ala Gly 
            340                 345                 350         
Pro Phe Glu Thr Pro Val Leu His Ser Leu Gln Ser Arg Ala Gly Ala 
        355                 360                 365             
Pro Leu Pro Val Pro Arg Gly Pro Ser Ala Asp Leu Leu Glu Asp Leu 
    370                 375                 380                 
Ser Glu Ser Arg Glu Cys Val Asn Cys Gly Ser Ile Gln Thr Pro Leu 
385                 390                 395                 400 
Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly Leu 
                405                 410                 415     
Tyr Ser Lys Met Asn Gly Leu Ser Arg Pro Leu Ile Lys Pro Gln Lys 
            420                 425                 430         
Arg Val Pro Ser Ser Arg Arg Leu Gly Leu Ser Cys Ala Asn Cys His 
        435                 440                 445             
Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly Glu Pro Val 
    450                 455                 460                 
Cys Asn Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val Pro Arg Pro 
465                 470                 475                 480 
Leu Ala Met Lys Lys Glu Gly Ile Gln Thr Arg Lys Arg Lys Pro Lys 
                485                 490                 495     
Asn Ile Asn Lys Ser Lys Thr Cys Ser Gly Asn Ser Asn Asn Ser Ile 
            500                 505                 510         
Pro Met Thr Pro Thr Ser Thr Ser Ser Asn Ser Asp Asp Cys Ser Lys 
        515                 520                 525             
Asn Thr Ser Pro Thr Thr Gln Pro Thr Ala Ser Gly Ala Gly Ala Pro 
    530                 535                 540                 
Val Met Thr Gly Ala Gly Glu Ser Thr Asn Pro Glu Asn Ser Glu Leu 
545                 550                 555                 560 
Lys Tyr Ser Gly Gln Asp Gly Leu Tyr Ile Gly Val Ser Leu Ala Ser 
                565                 570                 575     
Pro Ala Glu Val Thr Ser Ser Val Arg Pro Asp Ser Trp Cys Ala Leu 
            580                 585                 590         
Ala Leu Ala 
        595 

<210> 51
<211> 371
<212> PRT
<213> Homo sapiens

<220> 
<223> Nkx2-1-Em

<400> 51
Met Ser Met Ser Pro Lys His Thr Thr Pro Phe Ser Val Ser Asp Ile 
1               5                   10                  15      
Leu Ser Pro Leu Glu Glu Ser Tyr Lys Lys Val Gly Met Glu Gly Gly 
            20                  25                  30          
Gly Leu Gly Ala Pro Leu Ala Ala Tyr Arg Gln Gly Gln Ala Ala Pro 
        35                  40                  45              
Pro Thr Ala Ala Met Gln Gln His Ala Val Gly His His Gly Ala Val 
    50                  55                  60                  
Thr Ala Ala Tyr His Met Thr Ala Ala Gly Val Pro Gln Leu Ser His 
65                  70                  75                  80  
Ser Ala Val Gly Gly Tyr Cys Asn Gly Asn Leu Gly Asn Met Ser Glu 
                85                  90                  95      
Leu Pro Pro Tyr Gln Asp Thr Met Arg Asn Ser Ala Ser Gly Pro Gly 
            100                 105                 110         
Trp Tyr Gly Ala Asn Pro Asp Pro Arg Phe Pro Ala Ile Ser Arg Phe 
        115                 120                 125             
Met Gly Pro Ala Ser Gly Met Asn Met Ser Gly Met Gly Gly Leu Gly 
    130                 135                 140                 
Ser Leu Gly Asp Val Ser Lys Asn Met Ala Pro Leu Pro Ser Ala Pro 
145                 150                 155                 160 
Arg Arg Lys Arg Arg Val Leu Phe Ser Gln Ala Gln Val Tyr Glu Leu 
                165                 170                 175     
Glu Arg Arg Phe Lys Gln Gln Lys Tyr Leu Ser Ala Pro Glu Arg Glu 
            180                 185                 190         
His Leu Ala Ser Met Ile His Leu Thr Pro Thr Gln Val Lys Ile Trp 
        195                 200                 205             
Phe Gln Asn His Arg Tyr Lys Met Lys Arg Gln Ala Lys Asp Lys Ala 
    210                 215                 220                 
Ala Gln Gln Gln Leu Gln Gln Asp Ser Gly Gly Gly Gly Gly Gly Gly 
225                 230                 235                 240 
Gly Thr Gly Cys Pro Gln Gln Gln Gln Ala Gln Gln Gln Ser Pro Arg 
                245                 250                 255     
Arg Val Ala Val Pro Val Leu Val Lys Asp Gly Lys Pro Cys Gln Ala 
            260                 265                 270         
Gly Ala Pro Ala Pro Gly Ala Ala Ser Leu Gln Gly His Ala Gln Gln 
        275                 280                 285             
Gln Ala Gln His Gln Ala Gln Ala Ala Gln Ala Ala Ala Ala Ala Ile 
    290                 295                 300                 
Ser Val Gly Ser Gly Gly Ala Gly Leu Gly Ala His Pro Gly His Gln 
305                 310                 315                 320 
Pro Gly Ser Ala Gly Gln Ser Pro Asp Leu Ala His His Ala Ala Ser 
                325                 330                 335     
Pro Ala Ala Leu Gln Gly Gln Val Ser Ser Leu Ser His Leu Asn Ser 
            340                 345                 350         
Ser Gly Ser Asp Tyr Gly Thr Met Ser Cys Ser Thr Leu Leu Tyr Gly 
        355                 360                 365             
Arg Thr Trp 
    370     

<210> 52
<211> 463
<212> PRT
<213> Homo sapiens

<220> 
<223> Foxa2-Em

<400> 52
Met His Ser Ala Ser Ser Met Leu Gly Ala Val Lys Met Glu Gly His 
1               5                   10                  15      
Glu Pro Ser Asp Trp Ser Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser 
            20                  25                  30          
Ser Val Ser Asn Met Asn Ala Gly Leu Gly Met Asn Gly Met Asn Thr 
        35                  40                  45              
Tyr Met Ser Met Ser Ala Ala Ala Met Gly Ser Gly Ser Gly Asn Met 
    50                  55                  60                  
Ser Ala Gly Ser Met Asn Met Ser Ser Tyr Val Gly Ala Gly Met Ser 
65                  70                  75                  80  
Pro Ser Leu Ala Gly Met Ser Pro Gly Ala Gly Ala Met Ala Gly Met 
                85                  90                  95      
Gly Gly Ser Ala Gly Ala Ala Gly Val Ala Gly Met Gly Pro His Leu 
            100                 105                 110         
Ser Pro Ser Leu Ser Pro Leu Gly Gly Gln Ala Ala Gly Ala Met Gly 
        115                 120                 125             
Gly Leu Ala Pro Tyr Ala Asn Met Asn Ser Met Ser Pro Met Tyr Gly 
    130                 135                 140                 
Gln Ala Gly Leu Ser Arg Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser 
145                 150                 155                 160 
Tyr Thr His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met 
                165                 170                 175     
Ala Ile Gln Gln Ser Pro Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr 
            180                 185                 190         
Gln Trp Ile Met Asp Leu Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg 
        195                 200                 205             
Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys Phe Leu 
    210                 215                 220                 
Lys Val Pro Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr 
225                 230                 235                 240 
Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg 
                245                 250                 255     
Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala 
            260                 265                 270         
Ala Gly Ala Ala Gly Ser Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala 
        275                 280                 285             
Ser Gln Ala Gln Leu Gly Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro 
    290                 295                 300                 
Ala Gly Thr Glu Ser Pro His Ser Ser Ala Ser Pro Cys Gln Glu His 
305                 310                 315                 320 
Lys Arg Gly Gly Leu Gly Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu 
                325                 330                 335     
Ser Pro Pro Glu Pro Ala Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala 
            340                 345                 350         
Ala His Leu Leu Gly Pro Pro His His Pro Gly Leu Pro Pro Glu Ala 
        355                 360                 365             
His Leu Lys Pro Glu His His Tyr Ala Phe Asn His Pro Phe Ser Ile 
    370                 375                 380                 
Asn Asn Leu Met Ser Ser Glu Gln Gln His His His Ser His His His 
385                 390                 395                 400 
His Gln Pro His Lys Met Asp Leu Lys Ala Tyr Glu Gln Val Met His 
                405                 410                 415     
Tyr Pro Gly Tyr Gly Ser Pro Met Pro Gly Ser Leu Ala Met Gly Pro 
            420                 425                 430         
Val Thr Asn Lys Thr Gly Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr 
        435                 440                 445             
Ser Tyr Tyr Gln Gly Val Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455                 460             

<210> 53
<211> 134
<212> PRT
<213> Homo sapiens

<220> 
<223> Id2-Em

<400> 53
Met Lys Ala Phe Ser Pro Val Arg Ser Val Arg Lys Asn Ser Leu Ser 
1               5                   10                  15      
Asp His Ser Leu Gly Ile Ser Arg Ser Lys Thr Pro Val Asp Asp Pro 
            20                  25                  30          
Met Ser Leu Leu Tyr Asn Met Asn Asp Cys Tyr Ser Lys Leu Lys Glu 
        35                  40                  45              
Leu Val Pro Ser Ile Pro Gln Asn Lys Lys Val Ser Lys Met Glu Ile 
    50                  55                  60                  
Leu Gln His Val Ile Asp Tyr Ile Leu Asp Leu Gln Ile Ala Leu Asp 
65                  70                  75                  80  
Ser His Pro Thr Ile Val Ser Leu His His Gln Arg Pro Gly Gln Asn 
                85                  90                  95      
Gln Ala Ser Arg Thr Pro Leu Thr Thr Leu Asn Thr Asp Ile Ser Ile 
            100                 105                 110         
Leu Ser Leu Gln Ala Ser Glu Phe Pro Ser Glu Leu Met Ser Asn Asp 
        115                 120                 125             
Ser Lys Ala Leu Cys Gly 
    130                 

<210> 54
<211> 449
<212> PRT
<213> Homo sapiens

<220> 
<223> Gata6-Ad

<400> 54
Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln Gly Pro Ala Ala Tyr 
1               5                   10                  15      
Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala Ala Ala Ala Ala Ala 
            20                  25                  30          
Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val Pro Thr Thr Arg Val 
        35                  40                  45              
Gly Ser Met Leu Pro Gly Leu Pro Tyr His Leu Gln Gly Ser Gly Ser 
    50                  55                  60                  
Gly Pro Ala Asn His Ala Gly Gly Ala Gly Ala His Pro Gly Trp Pro 
65                  70                  75                  80  
Gln Ala Ser Ala Asp Ser Pro Pro Tyr Gly Ser Gly Gly Gly Ala Ala 
                85                  90                  95      
Gly Gly Gly Ala Ala Gly Pro Gly Gly Ala Gly Ser Ala Ala Ala His 
            100                 105                 110         
Val Ser Ala Arg Phe Pro Tyr Ser Pro Ser Pro Pro Met Ala Asn Gly 
        115                 120                 125             
Ala Ala Arg Glu Pro Gly Gly Tyr Ala Ala Ala Gly Ser Gly Gly Ala 
    130                 135                 140                 
Gly Gly Val Ser Gly Gly Gly Ser Ser Leu Ala Ala Met Gly Gly Arg 
145                 150                 155                 160 
Glu Pro Gln Tyr Ser Ser Leu Ser Ala Ala Arg Pro Leu Asn Gly Thr 
                165                 170                 175     
Tyr His His His His His His His His His His Pro Ser Pro Tyr Ser 
            180                 185                 190         
Pro Tyr Val Gly Ala Pro Leu Thr Pro Ala Trp Pro Ala Gly Pro Phe 
        195                 200                 205             
Glu Thr Pro Val Leu His Ser Leu Gln Ser Arg Ala Gly Ala Pro Leu 
    210                 215                 220                 
Pro Val Pro Arg Gly Pro Ser Ala Asp Leu Leu Glu Asp Leu Ser Glu 
225                 230                 235                 240 
Ser Arg Glu Cys Val Asn Cys Gly Ser Ile Gln Thr Pro Leu Trp Arg 
                245                 250                 255     
Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly Leu Tyr Ser 
            260                 265                 270         
Lys Met Asn Gly Leu Ser Arg Pro Leu Ile Lys Pro Gln Lys Arg Val 
        275                 280                 285             
Pro Ser Ser Arg Arg Leu Gly Leu Ser Cys Ala Asn Cys His Thr Thr 
    290                 295                 300                 
Thr Thr Thr Leu Trp Arg Arg Asn Ala Glu Gly Glu Pro Val Cys Asn 
305                 310                 315                 320 
Ala Cys Gly Leu Tyr Met Lys Leu His Gly Val Pro Arg Pro Leu Ala 
                325                 330                 335     
Met Lys Lys Glu Gly Ile Gln Thr Arg Lys Arg Lys Pro Lys Asn Ile 
            340                 345                 350         
Asn Lys Ser Lys Thr Cys Ser Gly Asn Ser Asn Asn Ser Ile Pro Met 
        355                 360                 365             
Thr Pro Thr Ser Thr Ser Ser Asn Ser Asp Asp Cys Ser Lys Asn Thr 
    370                 375                 380                 
Ser Pro Thr Thr Gln Pro Thr Ala Ser Gly Ala Gly Ala Pro Val Met 
385                 390                 395                 400 
Thr Gly Ala Gly Glu Ser Thr Asn Pro Glu Asn Ser Glu Leu Lys Tyr 
                405                 410                 415     
Ser Gly Gln Asp Gly Leu Tyr Ile Gly Val Ser Leu Ala Ser Pro Ala 
            420                 425                 430         
Glu Val Thr Ser Ser Val Arg Pro Asp Ser Trp Cys Ala Leu Ala Leu 
        435                 440                 445             
Ala 
    

<210> 55
<211> 401
<212> PRT
<213> Homo sapiens

<220> 
<223> Nkx2-1-Ad

<400> 55
Met Trp Ser Gly Gly Ser Gly Lys Ala Arg Gly Trp Glu Ala Ala Ala 
1               5                   10                  15      
Gly Gly Arg Ser Ser Pro Gly Arg Leu Ser Arg Arg Arg Ile Met Ser 
            20                  25                  30          
Met Ser Pro Lys His Thr Thr Pro Phe Ser Val Ser Asp Ile Leu Ser 
        35                  40                  45              
Pro Leu Glu Glu Ser Tyr Lys Lys Val Gly Met Glu Gly Gly Gly Leu 
    50                  55                  60                  
Gly Ala Pro Leu Ala Ala Tyr Arg Gln Gly Gln Ala Ala Pro Pro Thr 
65                  70                  75                  80  
Ala Ala Met Gln Gln His Ala Val Gly His His Gly Ala Val Thr Ala 
                85                  90                  95      
Ala Tyr His Met Thr Ala Ala Gly Val Pro Gln Leu Ser His Ser Ala 
            100                 105                 110         
Val Gly Gly Tyr Cys Asn Gly Asn Leu Gly Asn Met Ser Glu Leu Pro 
        115                 120                 125             
Pro Tyr Gln Asp Thr Met Arg Asn Ser Ala Ser Gly Pro Gly Trp Tyr 
    130                 135                 140                 
Gly Ala Asn Pro Asp Pro Arg Phe Pro Ala Ile Ser Arg Phe Met Gly 
145                 150                 155                 160 
Pro Ala Ser Gly Met Asn Met Ser Gly Met Gly Gly Leu Gly Ser Leu 
                165                 170                 175     
Gly Asp Val Ser Lys Asn Met Ala Pro Leu Pro Ser Ala Pro Arg Arg 
            180                 185                 190         
Lys Arg Arg Val Leu Phe Ser Gln Ala Gln Val Tyr Glu Leu Glu Arg 
        195                 200                 205             
Arg Phe Lys Gln Gln Lys Tyr Leu Ser Ala Pro Glu Arg Glu His Leu 
    210                 215                 220                 
Ala Ser Met Ile His Leu Thr Pro Thr Gln Val Lys Ile Trp Phe Gln 
225                 230                 235                 240 
Asn His Arg Tyr Lys Met Lys Arg Gln Ala Lys Asp Lys Ala Ala Gln 
                245                 250                 255     
Gln Gln Leu Gln Gln Asp Ser Gly Gly Gly Gly Gly Gly Gly Gly Thr 
            260                 265                 270         
Gly Cys Pro Gln Gln Gln Gln Ala Gln Gln Gln Ser Pro Arg Arg Val 
        275                 280                 285             
Ala Val Pro Val Leu Val Lys Asp Gly Lys Pro Cys Gln Ala Gly Ala 
    290                 295                 300                 
Pro Ala Pro Gly Ala Ala Ser Leu Gln Gly His Ala Gln Gln Gln Ala 
305                 310                 315                 320 
Gln His Gln Ala Gln Ala Ala Gln Ala Ala Ala Ala Ala Ile Ser Val 
                325                 330                 335     
Gly Ser Gly Gly Ala Gly Leu Gly Ala His Pro Gly His Gln Pro Gly 
            340                 345                 350         
Ser Ala Gly Gln Ser Pro Asp Leu Ala His His Ala Ala Ser Pro Ala 
        355                 360                 365             
Ala Leu Gln Gly Gln Val Ser Ser Leu Ser His Leu Asn Ser Ser Gly 
    370                 375                 380                 
Ser Asp Tyr Gly Thr Met Ser Cys Ser Thr Leu Leu Tyr Gly Arg Thr 
385                 390                 395                 400 
Trp 
    

<210> 56
<211> 457
<212> PRT
<213> Homo sapiens

<220> 
<223> Foxa2-Ad

<400> 56
Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser 
1               5                   10                  15      
Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          
Ala Gly Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala 
        35                  40                  45              
Ala Ala Met Gly Ser Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn 
    50                  55                  60                  
Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met 
65                  70                  75                  80  
Ser Pro Gly Ala Gly Ala Met Ala Gly Met Gly Gly Ser Ala Gly Ala 
                85                  90                  95      
Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro 
            100                 105                 110         
Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala 
        115                 120                 125             
Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg 
    130                 135                 140                 
Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro 
145                 150                 155                 160 
Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro 
                165                 170                 175     
Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu 
            180                 185                 190         
Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg 
        195                 200                 205             
His Ser Leu Ser Phe Asn Asp Cys Phe Leu Lys Val Pro Arg Ser Pro 
    210                 215                 220                 
Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly 
225                 230                 235                 240 
Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys 
                245                 250                 255     
Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala Ala Gly Ala Ala Gly Ser 
            260                 265                 270         
Gly Lys Lys Ala Ala Ala Gly Ala Gln Ala Ser Gln Ala Gln Leu Gly 
        275                 280                 285             
Glu Ala Ala Gly Pro Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser Pro 
    290                 295                 300                 
His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu Gly 
305                 310                 315                 320 
Glu Leu Lys Gly Thr Pro Ala Ala Ala Leu Ser Pro Pro Glu Pro Ala 
                325                 330                 335     
Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly Pro 
            340                 345                 350         
Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu His 
        355                 360                 365             
His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser Ser 
    370                 375                 380                 
Glu Gln Gln His His His Ser His His His His Gln Pro His Lys Met 
385                 390                 395                 400 
Asp Leu Lys Ala Tyr Glu Gln Val Met His Tyr Pro Gly Tyr Gly Ser 
                405                 410                 415     
Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys Thr Gly 
            420                 425                 430         
Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln Gly Val 
        435                 440                 445             
Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455         

<210> 57
<211> 141
<212> PRT
<213> Homo sapiens

<220> 
<223> Id2-Ad

<400> 57
Met Lys Ala Phe Ser Pro Val Arg Ser Val Arg Lys Asn Ser Leu Ser 
1               5                   10                  15      
Asp His Ser Leu Gly Ile Ser Arg Ser Lys Thr Pro Val Asp Asp Pro 
            20                  25                  30          
Met Ser Leu Leu Tyr Asn Met Asn Asp Cys Tyr Ser Lys Leu Lys Glu 
        35                  40                  45              
Leu Val Pro Ser Ile Pro Gln Asn Lys Lys Val Ser Lys Met Glu Ile 
    50                  55                  60                  
Leu Gln His Val Ile Asp Tyr Ile Leu Asp Leu Gln Ile Ala Leu Asp 
65                  70                  75                  80  
Ser His Pro Thr Ile Val Ser Leu His His Gln Arg Pro Gly Gln Asn 
                85                  90                  95      
Gln Ala Ser Arg Thr Pro Leu Thr Thr Leu Asn Thr Asp Ile Ser Ile 
            100                 105                 110         
Leu Ser Leu Gln Val Arg Pro Ala Pro Gly Ser Pro Pro Arg Arg Arg 
        115                 120                 125             
Thr Leu Pro Arg Ser Ser Gly Leu Ser Leu Gly Asp Pro 
    130                 135                 140     

<210> 58
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Target sequence of Gata6-Em"
      /organism="Artificial Sequence"

<400> 58
aatcaggagc gcaggctgca g                                              21


<210> 59
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Target sequence of Gata6-Em"
      /organism="Artificial Sequence"

<400> 59
aagaggcgcc tcctctctcc t                                              21


<210> 60
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Target sequence of Foxa2-Em"
      /organism="Artificial Sequence"

<400> 60
aaaccgccat gcactcggct t                                              21


<210> 61
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..24
<223> /mol_type="unassigned DNA"
      /note="Primers for HPRT Fwd"
      /organism="Artificial Sequence"

<400> 61
tgaccttgat ttattttgca tacc                                           24


<210> 62
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..23
<223> /mol_type="unassigned DNA"
      /note="Primers for HPRT Fwd"
      /organism="Artificial Sequence"

<400> 62
tttgctttcc ttggtcaggc agt                                            23


<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for HPRT Rev"
      /organism="Artificial Sequence"

<400> 63
cgagcaagac gttcagtcct                                                20


<210> 64
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..22
<223> /mol_type="unassigned DNA"
      /note="Primers for HPRT Rev"
      /organism="Artificial Sequence"

<400> 64
cgtggggtcc ttttcaccag ca                                             22


<210> 65
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Primers for Gapdh Fwd"
      /organism="Artificial Sequence"

<400> 65
tgagtatgtc gtggagtcta c                                              21


<210> 66
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /mol_type="unassigned DNA"
      /note="Primers for Gapdh Fwd"
      /organism="Artificial Sequence"

<400> 66
gcaaattcca tggcaccgt                                                 19


<210> 67
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Primers for Gapdh Fwd"
      /organism="Artificial Sequence"

<400> 67
ggcccgattt ctcctccggg t                                              21


<210> 68
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /mol_type="unassigned DNA"
      /note="Primers for Gapdh Rev"
      /organism="Artificial Sequence"

<400> 68
tggactgtgg tcatgagcc                                                 19


<210> 69
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /mol_type="unassigned DNA"
      /note="Primers for Gapdh Rev"
      /organism="Artificial Sequence"

<400> 69
tcgccccact tgattttgg                                                 19


<210> 70
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Primers for Gapdh Rev"
      /organism="Artificial Sequence"

<400> 70
ggtgaccagg cgcccaatac g                                              21


<210> 71
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..25
<223> /mol_type="unassigned DNA"
      /note="Primers for Gata6-Em Fwd"
      /organism="Artificial Sequence"

<400> 71
gctagcgctg tttgtttagg gctcg                                          25


<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Gata6-Em Rev"
      /organism="Artificial Sequence"

<400> 72
gccccgaaac gcttcggcag                                                20


<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Gata6-Ad Fwd"
      /organism="Artificial Sequence"

<400> 73
tttggggtgg cctcggctct                                                20


<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Gata6-Ad Rev"
      /organism="Artificial Sequence"

<400> 74
ccaggccaac cgcacacctt                                                20


<210> 75
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..18
<223> /mol_type="unassigned DNA"
      /note="Primers for Nkx2-1-Em Fwd"
      /organism="Artificial Sequence"

<400> 75
gcggccatgc agcagcac                                                  18


<210> 76
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Nkx2-1-Em Rev"
      /organism="Artificial Sequence"

<400> 76
ccatgttctt gctcacgtcc                                                20


<210> 77
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Primers for Nkx2-1-Ad Fwd"
      /organism="Artificial Sequence"

<400> 77
actcttttgg tggtgactgg g                                              21


<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Nk2-1-Ad Rev"
      /organism="Artificial Sequence"

<400> 78
ctcatgttgc ccaggttgcc                                                20


<210> 79
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Foxa2-Var1 Fwd"
      /organism="Artificial Sequence"

<400> 79
accgccatgc actcggcttc                                                20


<210> 80
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Foxa2-Var1 Rev"
      /organism="Artificial Sequence"

<400> 80
ggctcattcc agcgcccaca                                                20


<210> 81
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Foxa2-Var2 Fwd"
      /organism="Artificial Sequence"

<400> 81
ggcactgcgc ttcactcccc                                                20


<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Foxa2-Var2 Rev"
      /organism="Artificial Sequence"

<400> 82
ggctcattcc agcgcccaca                                                20


<210> 83
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Id2-Var1 Fwd"
      /organism="Artificial Sequence"

<400> 83
ctgaaccgag cctggtgccg                                                20


<210> 84
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Id2-Var1 Rev"
      /organism="Artificial Sequence"

<400> 84
gctccgggag atgcccaagc                                                20


<210> 85
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..25
<223> /mol_type="unassigned DNA"
      /note="Primers for Id2-Var2 Fwd"
      /organism="Artificial Sequence"

<400> 85
gggtgctgaa agattccaaa cctcg                                          25


<210> 86
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..23
<223> /mol_type="unassigned DNA"
      /note="Primers for Id2-Var2 Rev"
      /organism="Artificial Sequence"

<400> 86
tgtgcccttc agtgtaggtg gca                                            23


<210> 87
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Snai1 Fwd"
      /organism="Artificial Sequence"

<400> 87
ccgaagccac acgctgcctt                                                20


<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Snai1 Rev"
      /organism="Artificial Sequence"

<400> 88
agcacggttg cagtgggagc                                                20


<210> 89
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /mol_type="unassigned DNA"
      /note="Primers for Acta2 Fwd"
      /organism="Artificial Sequence"

<400> 89
gctggtgatg atgctccca                                                 19


<210> 90
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Primers for Acta2 Rev"
      /organism="Artificial Sequence"

<400> 90
gcccattcca accattactc c                                              21


<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Primers for Pou5f1 Fwd"
      /organism="Artificial Sequence"

<400> 91
tgtggacctc aggttggact                                                20


<210> 92
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Primers for Pou5f1 Rev"
      /organism="Artificial Sequence"

<400> 92
cttctgcagg gctttcatgt c                                              21


<210> 93
<211> 3270
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..3270
<223> /mol_type="unassigned DNA"
      /note="Gata6-Em"
      /organism="Mus musculus"

<400> 93
ttcacctccg cacccagcag cttgtagaga gcagttccga cccacagcct ggcacccttc       60

ggctagcgct gtttgtttag ggctcggtga gtccaatcag gagcgcaggc tgcagttttc      120

cggcagagca gtaagaggcg cctcctctct cctttttatt caccagcagc gactagcaga      180

ccccggactc tcgctctccc gccggcgccc tccgcctctc tccgcgcccc ggagcaccct      240

cggtcgcggc cgttcttctc gcacatcgct cgaggaatca aaagtcaggt tggagtagcg      300

ccggacagtg gatggccttg actgacggcg gctggtgcct gccaaagcgt ttcggggctg      360

ctgctgcgga cgccggcgac tccgggccct ttccagcgcg ggagccctcc tcgccgcttt      420

cccccatctc gtcttcgtcc tcctcctgct cccggggcgg ggatcgcggt ccctgcggcg      480

ccagcaactg caggacgccg cagctcgacg ccgaggcggt ggcgggacct ccgggccgct      540

cgctcttgct cagcccctac gcctcgcatc ccttcgccgc tgcccacgga gccgcggcgc      600

ccggggtcgc aggccccggg agcgccctgt cgacttggga ggacctgttg ctcttcactg      660

acctcgatca ggccgcgacc gccagcaagc tgttgtggtc cagccggggc gccaaactga      720

gccccttcgc ggccgagcag ccggaggaaa tgtaccagac cctcgccgcc ctgtccagcc      780

aggggcccgc cgcttacgac ggcgcgcccg gcggcttcgt gcactccgca gcggcggcgg      840

ccgctgccgc cgcggcagcc agctccccgg tctacgtgcc caccacgcgc gtgggctcca      900

tgctgtccgg cctgccctac cttcaagggg cgggcagcgg gcccagcaat cacgcgggcg      960

gagcgggtgc ccacccaggc tggtcccagg cctccgccga cagccccccg tatggcgggg     1020

gtggcgcagc cggcggcggc gcggccggac ctggaggtgc gggatcggct acggcccacg     1080

cctctgcacg ctttccctac tcgcccagcc cgcccatggc caacggcgcc gcgcgagacc     1140

ccgggggcta cgtggctgcg ggcggcacgg gcgcaggcag tgtgagtgga ggtggcggca     1200

gcctggcggc catgggtggc cgggagcacc agtacagctc gctgtccgca gctcggccgc     1260

tgaacggaac gtaccaccac caccatcacc atcacccgac ctactcgccc tacatggccg     1320

caccgctgac tcctgcctgg ccagcaggac ccttcgaaac gccggtgctc cacagcttac     1380

agggccgcgc gggagctcca ctcccggtgc cacggggccc cagcacagac ctgttggagg     1440

acctgtcgga gagccgcgag tgcgtgaact gcggctccat ccagacgcca ctgtggagac     1500

gagacggcac cggtcattac ctgtgcaatg catgcggtct ctacagcaag atgaatggcc     1560

tcagcaggcc cctcatcaag ccacagaagc gcgtgccttc atcacggcgg cttggactgt     1620

cctgtgccaa ctgtcacacc acaaccacta ccttatggcg tagaaatgct gagggtgagc     1680

ctgtgtgcaa tgcttgcggg ctctatatga aactccatgg ggtgcctcga ccacttgcta     1740

tgaaaaaaga aggaattcaa accaggaaac gaaaacctaa aaatataaat aagtcaaaag     1800

cttgctccgg taacagcagt ggctctgtcc ctatgactcc tacttcctct tcttctaatt     1860

cagatgactg caccaaaaat acttctcctt ctacacaagc gaccacctca ggggtagggg     1920

catcagtgat gtctgcagtg ggagaaaacg ccaaccccga gaacagtgac ctcaagtatt     1980

caggtcaaga cggcctctac ataggtgtca gtctgtcctc ccctgccgaa gtcacatcct     2040

ccgtgcgaca ggattcttgg tgtgctctgg ccctggcctg agctggtgct accaagaggc     2100

aaggagggct ctgaaggcct cataccactt gtgtctgata ttgtccagca gtccagatgg     2160

cagcaaaaat gcagacataa cattccttcg atgcgtgatt tctgtgcctt tgttttgaaa     2220

gagatatatt tctcaagaag cttactgaag taagaagaga tgggcttttg caggaagggc     2280

cagcaccgtg ggcatgtggc ctgctcctgc cagcctgggc tgcttcctgc ctctgactct     2340

gccccatacc agtgggagaa actgtgacaa tgaccggggc cttgtctgct aaggaagatt     2400

gagagattta agagaaaatg tttgtgtatt gctccaaatc atgtgcttct tgtgatcaac     2460

ctcggttatc ccagaaccca ttcatccccg accaccgtgc acatttcaca agcgttcgtg     2520

gagaggagca ctgggagcca tttggtctat cctggaggcg gagtgcattc ctggggtctc     2580

aacaagaata ttaatttgca agattgcatc atgacagaca ctgactgact tatctcaacg     2640

ttcatcgtaa cgtggctgat ctgaggtcac ttggaatttg taaacagggt agcaaacaag     2700

atatttttct tccatgtaca caataatttt tttaagtgca atttgcgttg cagcaatcag     2760

tgttaaatca tttgcataag atttaacagc atttttataa tgaatgtaaa cattttaact     2820

taatggtact taaaataatt taaaaaaaag ttaactttag acatatgctt cttacactca     2880

cagcccactt ctgtgttccc aattgtttaa aagaaaaaaa aaaagatttc aagaacaaat     2940

cttctctcag gaaattgcct tttctccatt tatgaatttt tatacaagaa caccaacaca     3000

gtccccgttc ttttactgag gaaaaagtgc tggaaattgc aacaaacctt tactacctag     3060

agaatagcat ttgtaaatat tctaagtatc tgtaacactc ttgacgcctg taccacgtga     3120

ccaacccaca ggttggttta cattattatt ttttttaatg ggatatcata tggaaaccta     3180

tttcaccaga gttttaaaaa ataaaaaggg tattgttttg tgttctgtac agtgagatcc     3240

ttccttttca tcttatttca atgctgtgtg                                      3270


<210> 94
<211> 2097
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..2097
<223> /mol_type="unassigned DNA"
      /note="Gata6-Ad"
      /organism="Mus musculus"

<400> 94
tgggcattaa ttttagtgtg gttatctccg atgagcctaa gcgatttgga aaagcagccc      60

ggtggaggcc tgcctggttc cccaccccct ccaagtctcc ctgtcattct tcctgctctc     120

ccctttgggg tggcctcggc tctggggcgg tctcaccccc ctcccctcct gcgttttccc     180

ctccttttct ctgcgctctg ctccacccta ctatgaccaa ttccagaacg atctggcctt     240

tcccctgctg gggttgacca tggggtgggc caggggtggc ccggcccgcc tgagtacgca     300

cgctggtggt tgtaaggcgg tttgtgttta aggaatcaaa agtcaggttg gagtagcgcc     360

ggacagtgga tggccttgac tgacggcggc tggtgcctgc caaagcgttt cggggctgct     420

gctgcggacg ccggcgactc cgggcccttt ccagcgcggg agccctcctc gccgctttcc     480

cccatctcgt cttcgtcctc ctcctgctcc cggggcgggg atcgcggtcc ctgcggcgcc     540

agcaactgca ggacgccgca gctcgacgcc gaggcggtgg cgggacctcc gggccgctcg     600

ctcttgctca gcccctacgc ctcgcatccc ttcgccgctg cccacggagc cgcggcgccc     660

ggggtcgcag gccccgggag cgccctgtcg acttgggagg acctgttgct cttcactgac     720

ctcgatcagg ccgcgaccgc cagcaagctg ttgtggtcca gccggggcgc caaactgagc     780

cccttcgcgg ccgagcagcc ggaggaaatg taccagaccc tcgccgccct gtccagccag     840

gggcccgccg cttacgacgg cgcgcccggc ggcttcgtgc actccgcagc ggcggcggcc     900

gctgccgccg cggcagccag ctccccggtc tacgtgccca ccacgcgcgt gggctccatg     960

ctgtccggcc tgccctacct tcaaggggcg ggcagcgggc ccagcaatca cgcgggcgga    1020

gcgggtgccc acccaggctg gtcccaggcc tccgccgaca gccccccgta tggcgggggt    1080

ggcgcagccg gcggcggcgc ggccggacct ggaggtgcgg gatcggctac ggcccacgcc    1140

tctgcacgct ttccctactc gcccagcccg cccatggcca acggcgccgc gcgagacccc    1200

gggggctacg tggctgcggg cggcacgggc gcaggcagtg tgagtggagg tggcggcagc    1260

ctggcggcca tgggtggccg ggagcaccag tacagctcgc tgtccgcagc tcggccgctg    1320

aacggaacgt accaccacca ccatcaccat cacccgacct actcgcccta catggccgca    1380

ccgctgactc ctgcctggcc agcaggaccc ttcgaaacgc cggtgctcca cagcttacag    1440

ggccgcgcgg gagctccact cccggtgcca cggggcccca gcacagacct gttggaggac    1500

ctgtcggaga gccgcgagtg cgtgaactgc ggctccatcc agacgccact gtggagacga    1560

gacggcaccg gtcattacct gtgcaatgca tgcggtctct acagcaagat gaatggcctc    1620

agcaggcccc tcatcaagcc acagaagcgc gtgccttcat cacggcggct tggactgtcc    1680

tgtgccaact gtcacaccac aaccactacc ttatggcgta gaaatgctga gggtgagcct    1740

gtgtgcaatg cttgcgggct ctatatgaaa ctccatgggg tatgttgctc ctgtttatcc    1800

atacatacaa ctagcacctg aattgtaaat ttttagttat aagacagaat cagcaaatga    1860

aaaaaggtgt aaaagtgtgt acatatgcct tgtagcgaat tcaagctgct cttaattgta    1920

atgtgaccag tcagttcagc cactaaggag ccaggagata aaacccacta ccaaccaatc    1980

cggcactaac attctctgtg aaacatctct acattttaga aatgtgaaaa tgagccaagt    2040

gtaactgtga atgcctttaa tccaagatag ccagggctac acggagaaac ctgtagc       2097


<210> 95
<211> 2265
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..2265
<223> /mol_type="unassigned DNA"
      /note="Nkx2-1-Em"
      /organism="Mus musculus"

<400> 95
tttttttttt cctcctcttc cttcctcctc cagccgacgc cgaatcatgt cgatgagtcc      60

aaagcacacg actccgttct cagtgtctga catcttgagt cccctggagg aaagctacaa     120

gaaagtgggc atggagggcg gcggcctcgg ggctccgctc gcagcgtaca gacagggcca     180

ggcggcccca ccggccgcgg ccatgcagca gcacgccgtg gggcaccacg gcgccgtcac     240

cgccgcctac cacatgacgg cggcgggggt gccccagctc tcgcactccg ccgtgggggg     300

ctactgcaac ggcaacctgg gcaacatgag cgagctgccg ccttaccagg acaccatgcg     360

gaacagcgct tcgggccccg gatggtacgg cgccaaccca gacccgcgct tccccgccat     420

ctcccgcttc atgggcccgg cgagcggcat gaatatgagt ggcatgggcg gcctgggctc     480

gctgggggac gtgagcaaga acatggcccc gctgcccagt gcgccccgcc ggaagcgccg     540

ggtgctcttc tcccaggcgc aggtgtacga gctcgagcga cgtttcaagc aacagaagta     600

cctgtcggcg ccggagcgcg agcatctggc cagcatgatt cacctgacac ccacgcaggt     660

caagatctgg ttccagaacc accgctacaa gatgaagcgc caggctaagg acaaggcggc     720

gcagcaacaa ctgcagcagg acagcggcgg cggcggaggc ggcggtggcg gtgcgggatg     780

cccgcagcag cagcaagctc agcagcagtc gccgcgccgg gtggccgtgc cggtcctagt     840

caaagacggc aaaccctgcc aggcgggcgc ccctgccccg ggagccgcaa gcctgcaaag     900

ccacgcgcag caacaagctc agcagcaggc gcaggcggcg caagcggctg ccgcggccat     960

ctcagtgggc agcggtggcg cgggtctagg agcacaccca ggccaccagc cgggcagcgc    1020

agggcagtcc ccggacctgg cgcaccacgc agccagcccc gcggggctgc agggccaggt    1080

ctccagccta tcccatctga actcctcggg ctcggactat ggcgccatgt cttgttctac    1140

cttgctttat ggtcggacct ggtgagacgt gagatgcgct tgagccccgc gcgacctcaa    1200

cgcttcccct ctgccttccg caaagaccac cattcgcccg ctgctccacg cgcttctact    1260

ttttttaaga atctgtttat gtttagacca aggaaaagta cacaaagacc aaactgctgg    1320

acgacttctt cttcttcttc ttcttcttct tcttcttctt cttcttcttc ttcttcttct    1380

tcttcttctt cttcttcttc ttcttcttct tctcctcctc ctcctcctcc tcctcctcct    1440

cctcctcttc ctccttcttg tccccgctcg ttcttttctt tctccccctc ctcttctgtt    1500

tccttcttcc ttcatctttc cccccttcct ttctctttac tatctaaaac ttgcagactt    1560

tttgtttttt aacataaaaa gaaaatagaa acagccaagc aaattcaacc ctttacggat    1620

tctttaaaca gagaaggaca gagaacaaat ttggggtgtc tttctggtag ttcaaatggg    1680

ttcccaagct taggcatggc acagttttgg agcctgttct atgcttccat ggccctgaac    1740

tctaaagacg gaaaactttt ctgtggatgc accctgccag caaagtgagc ttgcttgtaa    1800

ataccaggat ttttcgtttg tttgtatgtt tcagaaggga ggacagacgc tggagatagg    1860

aaagtcttca gcataaccca tttgtacctg acacaaagga agtgtcccct cccaggcgcc    1920

ctctggccct acaggttcag tccaggctgg cctttcagaa aattgtttta ggtttgatgt    1980

gaacttgtag ctgtaaaatg ctgttaaaag ttggactaaa tgcctagttt ttagtaacct    2040

gtacattatg ttgtaaaaag aaccccagtc ccagtcccta gtccctcact ttttcaaggg    2100

gcattgacaa acctgtgtat attatttggc agtttggtat ttgcagcacc aatccttttt    2160

ttttttctgt tgtaacttat gtagatattt ggcttaaata tagttcctaa gaagcttcta    2220

ataaattata cgaattaaaa aagatggttt ttttcctgat taaaa                    2265


<210> 96
<211> 2832
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..2832
<223> /mol_type="unassigned DNA"
      /note="Nkx2-1 Ad"
      /organism="Mus musculus"

<400> 96
ctggtaacag caatgaggct gacgcccccg ggcccgctag ggagcacagc ccacagctcc      60

cccttgccag gcgcccaagg accctcaagg cgcggggctc acacttgaag cctgggaacg     120

ctcagacagg aaacccactt cctcctaagc agtttcttcc tagccggatg agaggcgccc     180

aattgaagca gaatgatcct catctactaa tatccagcgt ggccacaaag cgaccggcca     240

tttacgccgc cactttagac aaagatattt ggttattccc ggggaagcaa gtgcactttt     300

gcatggctga gctccgggag gaggcgagcc tcagcccagc ctcccgcccg ctgggctgcg     360

ggcgtcgaga tattcgcctc ctcccggaca acgagttcca cccgggttca gactcagttc     420

cactctgcaa cggatctgcg ggcgctcacg cggctccccg cccgggcttt cactgaagca     480

tcggaaggga aaactgcggg gatctgagct ggggtgctgg gactgggatg tcctcggaaa     540

gacagcatca gcttctgaag ccgaagtatc caggccatgg gcaagggtca ggggcaccag     600

ccgacgccga atcatgtcga tgagtccaaa gcacacgact ccgttctcag tgtctgacat     660

cttgagtccc ctggaggaaa gctacaagaa agtgggcatg gagggcggcg gcctcggggc     720

tccgctcgca gcgtacagac agggccaggc ggccccaccg gccgcggcca tgcagcagca     780

cgccgtgggg caccacggcg ccgtcaccgc cgcctaccac atgacggcgg cgggggtgcc     840

ccagctctcg cactccgccg tggggggcta ctgcaacggc aacctgggca acatgagcga     900

gctgccgcct taccaggaca ccatgcggaa cagcgcttcg ggccccggat ggtacggcgc     960

caacccagac ccgcgcttcc ccgccatctc ccgcttcatg ggcccggcga gcggcatgaa    1020

tatgagtggc atgggcggcc tgggctcgct gggggacgtg agcaagaaca tggccccgct    1080

gcccagtgcg ccccgccgga agcgccgggt gctcttctcc caggcgcagg tgtacgagct    1140

cgagcgacgt ttcaagcaac agaagtacct gtcggcgccg gagcgcgagc atctggccag    1200

catgattcac ctgacaccca cgcaggtcaa gatctggttc cagaaccacc gctacaagat    1260

gaagcgccag gctaaggaca aggcggcgca gcaacaactg cagcaggaca gcggcggcgg    1320

cggaggcggc ggtggcggtg cgggatgccc gcagcagcag caagctcagc agcagtcgcc    1380

gcgccgggtg gccgtgccgg tcctagtcaa agacggcaaa ccctgccagg cgggcgcccc    1440

tgccccggga gccgcaagcc tgcaaagcca cgcgcagcaa caagctcagc agcaggcgca    1500

ggcggcgcaa gcggctgccg cggccatctc agtgggcagc ggtggcgcgg gtctaggagc    1560

acacccaggc caccagccgg gcagcgcagg gcagtccccg gacctggcgc accacgcagc    1620

cagccccgcg gggctgcagg gccaggtctc cagcctatcc catctgaact cctcgggctc    1680

ggactatggc gccatgtctt gttctacctt gctttatggt cggacctggt gagacgtgag    1740

atgcgcttga gccccgcgcg acctcaacgc ttcccctctg ccttccgcaa agaccaccat    1800

tcgcccgctg ctccacgcgc ttctactttt tttaagaatc tgtttatgtt tagaccaagg    1860

aaaagtacac aaagaccaaa ctgctggacg acttcttctt cttcttcttc ttcttcttct    1920

tcttcttctt cttcttcttc ttcttcttct tcttcttctt cttcttcttc ttcttcttct    1980

cctcctcctc ctcctcctcc tcctcctcct cctcttcctc cttcttgtcc ccgctcgttc    2040

ttttctttct ccccctcctc ttctgtttcc ttcttccttc atctttcccc ccttcctttc    2100

tctttactat ctaaaacttg cagacttttt gttttttaac ataaaaagaa aatagaaaca    2160

gccaagcaaa ttcaaccctt tacggattct ttaaacagag aaggacagag aacaaatttg    2220

gggtgtcttt ctggtagttc aaatgggttc ccaagcttag gcatggcaca gttttggagc    2280

ctgttctatg cttccatggc cctgaactct aaagacggaa aacttttctg tggatgcacc    2340

ctgccagcaa agtgagcttg cttgtaaata ccaggatttt tcgtttgttt gtatgtttca    2400

gaagggagga cagacgctgg agataggaaa gtcttcagca taacccattt gtacctgaca    2460

caaaggaagt gtcccctccc aggcgccctc tggccctaca ggttcagtcc aggctggcct    2520

ttcagaaaat tgttttaggt ttgatgtgaa cttgtagctg taaaatgctg ttaaaagttg    2580

gactaaatgc ctagttttta gtaacctgta cattatgttg taaaaagaac cccagtccca    2640

gtccctagtc cctcactttt tcaaggggca ttgacaaacc tgtgtatatt atttggcagt    2700

ttggtatttg cagcaccaat cctttttttt tttctgttgt aacttatgta gatatttggc    2760

ttaaatatag ttcctaagaa gcttctaata aattatacga attaaaaaag atggtttttt    2820

tcctgattaa aa                                                        2832


<210> 97
<211> 2070
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..2070
<223> /mol_type="unassigned DNA"
      /note="Foxa2-var-1"
      /organism="Mus musculus"

<400> 97
ggtcgtttgt tgtggctgtt aaattttaaa ccgccatgca ctcggcttcc agtatgctgg      60

gagccgtgaa gatggaaggg cacgagccat ccgactggag cagctactac gcggagcccg     120

agggctactc ttccgtgagc aacatgaacg ccggcctggg gatgaatggc atgaacacat     180

acatgagcat gtccgcggct gccatgggcg gcggttccgg caacatgagc gcgggctcca     240

tgaacatgtc atcctatgtg ggcgctggaa tgagcccgtc gctagctggc atgtccccgg     300

gcgccggcgc catggcgggc atgagcggct cagccggggc ggccggcgtg gcgggcatgg     360

gacctcacct gagtccgagt ctgagcccgc tcgggggaca ggcggccggg gccatgggtg     420

gccttgcccc ctacgccaac atgaactcga tgagccccat gtacgggcag gccggcctga     480

gccgcgctcg ggaccccaag acataccgac gcagctacac acacgccaaa cctccctact     540

cgtacatctc gctcatcacc atggccatcc agcagagccc caacaagatg ctgacgctga     600

gcgagatcta tcagtggatc atggacctct tccctttcta ccggcagaac cagcagcgct     660

ggcagaactc catccgccac tctctctcct tcaacgactg ctttctcaag gtgccccgct     720

cgccagacaa gcctggcaag ggctccttct ggaccctgca cccagactcg ggcaacatgt     780

tcgagaacgg ctgctacctg cgccgccaga agcgcttcaa gtgtgagaag caactggcac     840

tgaaggaagc cgcgggtgcg gccagtagcg gaggcaagaa gaccgctcct gggtcccagg     900

cctctcaggc tcagctcggg gaggccgcgg gctcggcctc cgagactccg gcgggcaccg     960

agtcccccca ttccagcgct tctccgtgtc aggagcacaa gcgaggtggc ctaagcgagc    1020

taaagggagc acctgcctct gcgctgagtc ctcccgagcc ggcgccctcg cctgggcagc    1080

agcagcaggc tgcagcccac ctgctgggcc cacctcacca cccaggcctg ccaccagagg    1140

cccacctgaa gcccgagcac cattacgcct tcaaccaccc cttctctatc aacaacctca    1200

tgtcgtccga gcagcaacat caccacagcc accaccacca tcagccccac aaaatggacc    1260

tcaaggccta cgaacaggtc atgcactacc cagggggcta tggttccccc atgccaggca    1320

gcttggccat gggcccagtc acgaacaaag cgggcctgga tgcctcgccc ctggctgcag    1380

acacttccta ctaccaagga gtgtactcca ggcctattat gaactcatcc taagaagatg    1440

gctttcaggc cctgctagct ctggtcactg gggacaaggg aaatgagagg ctgagtggag    1500

actttgggag agctttgagg aaaagtagcc accacacttc aggcctcaag ggagcagtct    1560

cacctgtctg tgtccctaaa tagatgggcc acagtgatct gtcattctaa atagggaagg    1620

gaatggaaat atatatgtat acatataaac ttgttttaaa ggagcctttg gtctcctcta    1680

tgtagactac tgcttctcaa gacatctgca gagtttgatt tttgttgttg ttctctattg    1740

ctgttgttgc agaaaagtct gactttaaaa acaaacaaac aaacaaaaaa cttttgtgag    1800

tgacttggtg taaaaccatg tagttttaac agaaaaccag agggttgtac tgatgttgaa    1860

aagaggaaag aaaaataatg taagagtctg gtgtaccgga ccaggagaaa ggagaaaaac    1920

acatcccatt ctggacatgg tgaaatccag gtctcgggtc tgatttaatt tatggtttct    1980

gcgtgcttta tttatggctt ataaatgtgt gttctggcta gaatggccag aattccacaa    2040

atctatatta aagtgttatt gccgatttta                                     2070


<210> 98
<211> 2127
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..2127
<223> /mol_type="unassigned DNA"
      /note="Foxa2-var2"
      /organism="Mus musculus"

<400> 98
ctgacgacca gggcggccag accacgcgag tcctacgcgc ctcctgaggc cgccccggga      60

cttaactgta acggggaggg gcctccggag cagcggccag cgagttaaag tatgctggga     120

gccgtgaaga tggaagggca cgagccatcc gactggagca gctactacgc ggagcccgag     180

ggctactctt ccgtgagcaa catgaacgcc ggcctgggga tgaatggcat gaacacatac     240

atgagcatgt ccgcggctgc catgggcggc ggttccggca acatgagcgc gggctccatg     300

aacatgtcat cctatgtggg cgctggaatg agcccgtcgc tagctggcat gtccccgggc     360

gccggcgcca tggcgggcat gagcggctca gccggggcgg ccggcgtggc gggcatggga     420

cctcacctga gtccgagtct gagcccgctc gggggacagg cggccggggc catgggtggc     480

cttgccccct acgccaacat gaactcgatg agccccatgt acgggcaggc cggcctgagc     540

cgcgctcggg accccaagac ataccgacgc agctacacac acgccaaacc tccctactcg     600

tacatctcgc tcatcaccat ggccatccag cagagcccca acaagatgct gacgctgagc     660

gagatctatc agtggatcat ggacctcttc cctttctacc ggcagaacca gcagcgctgg     720

cagaactcca tccgccactc tctctccttc aacgactgct ttctcaaggt gccccgctcg     780

ccagacaagc ctggcaaggg ctccttctgg accctgcacc cagactcggg caacatgttc     840

gagaacggct gctacctgcg ccgccagaag cgcttcaagt gtgagaagca actggcactg     900

aaggaagccg cgggtgcggc cagtagcgga ggcaagaaga ccgctcctgg gtcccaggcc     960

tctcaggctc agctcgggga ggccgcgggc tcggcctccg agactccggc gggcaccgag    1020

tccccccatt ccagcgcttc tccgtgtcag gagcacaagc gaggtggcct aagcgagcta    1080

aagggagcac ctgcctctgc gctgagtcct cccgagccgg cgccctcgcc tgggcagcag    1140

cagcaggctg cagcccacct gctgggccca cctcaccacc caggcctgcc accagaggcc    1200

cacctgaagc ccgagcacca ttacgccttc aaccacccct tctctatcaa caacctcatg    1260

tcgtccgagc agcaacatca ccacagccac caccaccatc agccccacaa aatggacctc    1320

aaggcctacg aacaggtcat gcactaccca gggggctatg gttcccccat gccaggcagc    1380

ttggccatgg gcccagtcac gaacaaagcg ggcctggatg cctcgcccct ggctgcagac    1440

acttcctact accaaggagt gtactccagg cctattatga actcatccta agaagatggc    1500

tttcaggccc tgctagctct ggtcactggg gacaagggaa atgagaggct gagtggagac    1560

tttgggagag ctttgaggaa aagtagccac cacacttcag gcctcaaggg agcagtctca    1620

cctgtctgtg tccctaaata gatgggccac agtgatctgt cattctaaat agggaaggga    1680

atggaaatat atatgtatac atataaactt gttttaaagg agcctttggt ctcctctatg    1740

tagactactg cttctcaaga catctgcaga gtttgatttt tgttgttgtt ctctattgct    1800

gttgttgcag aaaagtctga ctttaaaaac aaacaaacaa acaaaaaact tttgtgagtg    1860

acttggtgta aaaccatgta gttttaacag aaaaccagag ggttgtactg atgttgaaaa    1920

gaggaaagaa aaataatgta agagtctggt gtaccggacc aggagaaagg agaaaaacac    1980

atcccattct ggacatggtg aaatccaggt ctcgggtctg atttaattta tggtttctgc    2040

gtgctttatt tatggcttat aaatgtgtgt tctggctaga atggccagaa ttccacaaat    2100

ctatattaaa gtgttattgc cgatttt                                        2127


<210> 99
<211> 1285
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..1285
<223> /mol_type="unassigned DNA"
      /note="Id2-var1"
      /organism="Mus musculus"

<400> 99
gcttcattct gaaccgagcc tggtgccgcg cagtcagctc agccccctgt ggcggctccc      60

tcccggtctt cctcctacga gcagcatgaa agccttcagt ccggtgaggt ccgttaggaa     120

aaacagcctg tcggaccaca gcttgggcat ctcccggagc aaaaccccgg tggacgaccc     180

gatgagtctg ctctacaaca tgaacgactg ctactccaag ctcaaggaac tggtgcccag     240

catcccccag aacaagaagg tgaccaagat ggaaatcctg cagcacgtca tcgattacat     300

cttggacctg cagatcgccc tggactcgca tcccactatc gtcagcctgc atcaccagag     360

acctggacag aaccaggcgt ccaggacgcc gctgaccacc ctgaacacgg acatcagcat     420

cctgtccttg caggcatctg aattcccttc tgagcttatg tcgaatgata gcaaagtact     480

ctgtggctaa ataaatggca tttggggact tttttttttc tttttacttt ctctttttct     540

tttgcacaag aagaagtcta caagatcttt taagactttt gttatcagcc atttcaccag     600

gagaacacgt tgaatggacc tttttaaaaa gaaagcggaa ggaaaactaa ggatgatcgt     660

cttgcccagg tgtcgttctc cggcctggac tgtgataccg ttatttatga gagactttca     720

gtgccctttc tacagttgga aggttttctt tatatactat tcccaccatg gggagcgaaa     780

acgttaaaaa aaaaagaaaa aaatcacaag gaattgccca atgtaagcag actttgcctt     840

ttcacaaagg tggagcgtga ataccagaag gacccagtat tcggttactt aaatgaagtc     900

ttcggtcaga aatggccttt ttgacacgag cctactgaat gctgtgtata tatttatata     960

taaatatata tatattgagt gaaccttgtg gactctttaa ttagagtttt cttgtatagt    1020

ggcagaaata acctatttct gcattaaaat gtaatgacgt acttatgcta aactttttat    1080

aaaagtttag ttgtaaactt aaccctttta tacaaaataa atcaagtgtg tttattgaat    1140

gttgattgct tgctttattt cagacaacca gtgctttgat tttttttatg ctatgttata    1200

actgaaccca aataaatacc agttcaaatt tatgtagact gtattaagat tataataaaa    1260

tgtgtctgac atcaatgccg ggatt                                          1285


<210> 100
<211> 1839
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..1839
<223> /mol_type="unassigned DNA"
      /note="Id2-var2"
      /organism="Mus musculus"

<400> 100
agcaaaacaa gaattcagaa ttaaagcatt ggagtcaaga gctctaaact ttttcaaaat      60

gtggctgcat ctaggaaggg tgctgaaaga ttccaaacct cgtacgtaac agaattttct     120

tttaaaaaca gcgataagct gtcagtcaat agctaggacc acctacctga caaagagctt     180

cccaagagct ctaagtgttg gaatgtgaca ccagaaatca cgatttgtgc ataattaatc     240

gcatcacttt gccacctaca ctgaagggca cagaccaagg gcagtgtatg taaatgtagt     300

tccagtgtgc aaaccccact aatgaccttc gattaatgga gtcattatag taaccctgcc     360

tcattcttgg gggtgggggg agttccgaat gcaccgggtc cctcggggct cctctgcggt     420

ctgagggaga ccgcacagtg ttcctacaat tcgtgtcact gagtttccga gaaggcctcc     480

cgcgttgctc caagttgcaa agcttcacgc taaacctgtc gtggacgtgt atgtgggcat     540

tggctgcgaa cgcggaagaa ccgagagctc atactcacca atgggagaat tcgcctggta     600

tgatggacgg gagcccttcc accaatggca attcagggat gcccgattga gcggccaggg     660

cgagtgcaca taaaagacgc cccgcccggc tcgcgcttca ttctgaaccg agcctggtgc     720

cgcgcagtca gctcagcccc ctgtggcggc tccctcccgg tcttcctcct acgagcagca     780

tgaaagcctt cagtccggtg aggtccgtta ggaaaaacag cctgtcggac cacagcttgg     840

gcatctcccg gagcaaaacc ccggtggacg acccgatgag tctgctctac aacatgaacg     900

actgctactc caagctcaag gaactggtgc ccagcatccc ccagaacaag aaggtgacca     960

agatggaaat cctgcagcac gtcatcgatt acatcttgga cctgcagatc gccctggact    1020

cgcatcccac tatcgtcagc ctgcatcacc agagacctgg acagaaccag gcgtccagga    1080

cgccgctgac caccctgaac acggacatca gcatcctgtc cttgcaggtg agactagctt    1140

gcaagtacgc cactgcccag acgctccggg tctcccgagc tgtcactctt aaagcccatc    1200

gtagagacag gttcattaac tttatttttg aggaaactgt atattgagcg tcatgtgaaa    1260

tcgctactta taagttctgt gtgggttgca tctggatctg cgctgtagca tgatcctgtt    1320

tcatgggact tgttggcact tttgtgaaag gaggaggggg gctaccttcc tttaagatta    1380

cctaatatcc tgccttttat cctctttctc cccaggcatc tgaattccct tctgagctta    1440

tgtcgaatga tagcaaagta ctctgtggct aaataaatgg tgagtgttgc gggtgcctcc    1500

tgtgtgcgcg tttcggtaat gtgcttgtgt gtctgttaaa tgtttggttt ggtaaatgca    1560

tgcttacttc actgtgttac gggtgccgct tgacttacca cataggcatg aaggggcttg    1620

tagctgtggt tgctcaggac tacagaacag ttgcctttac aaaaacagaa aagaaagaaa    1680

aaaaagaaag aaaagaaatg ccagtaactt actatgaagg tgtcaggacc aagtgtggct    1740

gacttttatg agcccagtgg cggtacactg aggtggtaac ctcagctgta attaatctta    1800

tcgccacaaa ttccatagtg attctctttt cccaaaact                           1839


<210> 101
<211> 589
<212> PRT
<213> Mus musculus

<220> 
<223> Gata6-Em

<400> 101
Met Ala Leu Thr Asp Gly Gly Trp Cys Leu Pro Lys Arg Phe Gly Ala 
1               5                   10                  15      
Ala Ala Ala Asp Ala Gly Asp Ser Gly Pro Phe Pro Ala Arg Glu Pro 
            20                  25                  30          
Ser Ser Pro Leu Ser Pro Ile Ser Ser Ser Ser Ser Ser Cys Ser Arg 
        35                  40                  45              
Gly Gly Asp Arg Gly Pro Cys Gly Ala Ser Asn Cys Arg Thr Pro Gln 
    50                  55                  60                  
Leu Asp Ala Glu Ala Val Ala Gly Pro Pro Gly Arg Ser Leu Leu Leu 
65                  70                  75                  80  
Ser Pro Tyr Ala Ser His Pro Phe Ala Ala Ala His Gly Ala Ala Ala 
                85                  90                  95      
Pro Gly Val Ala Gly Pro Gly Ser Ala Leu Ser Thr Trp Glu Asp Leu 
            100                 105                 110         
Leu Leu Phe Thr Asp Leu Asp Gln Ala Ala Thr Ala Ser Lys Leu Leu 
        115                 120                 125             
Trp Ser Ser Arg Gly Ala Lys Leu Ser Pro Phe Ala Ala Glu Gln Pro 
    130                 135                 140                 
Glu Glu Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln Gly Pro Ala 
145                 150                 155                 160 
Ala Tyr Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala Ala Ala Ala 
                165                 170                 175     
Ala Ala Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val Pro Thr Thr 
            180                 185                 190         
Arg Val Gly Ser Met Leu Ser Gly Leu Pro Tyr Leu Gln Gly Ala Gly 
        195                 200                 205             
Ser Gly Pro Ser Asn His Ala Gly Gly Ala Gly Ala His Pro Gly Trp 
    210                 215                 220                 
Ser Gln Ala Ser Ala Asp Ser Pro Pro Tyr Gly Gly Gly Gly Ala Ala 
225                 230                 235                 240 
Gly Gly Gly Ala Ala Gly Pro Gly Gly Ala Gly Ser Ala Thr Ala His 
                245                 250                 255     
Ala Ser Ala Arg Phe Pro Tyr Ser Pro Ser Pro Pro Met Ala Asn Gly 
            260                 265                 270         
Ala Ala Arg Asp Pro Gly Gly Tyr Val Ala Ala Gly Gly Thr Gly Ala 
        275                 280                 285             
Gly Ser Val Ser Gly Gly Gly Gly Ser Leu Ala Ala Met Gly Gly Arg 
    290                 295                 300                 
Glu His Gln Tyr Ser Ser Leu Ser Ala Ala Arg Pro Leu Asn Gly Thr 
305                 310                 315                 320 
Tyr His His His His His His His Pro Thr Tyr Ser Pro Tyr Met Ala 
                325                 330                 335     
Ala Pro Leu Thr Pro Ala Trp Pro Ala Gly Pro Phe Glu Thr Pro Val 
            340                 345                 350         
Leu His Ser Leu Gln Gly Arg Ala Gly Ala Pro Leu Pro Val Pro Arg 
        355                 360                 365             
Gly Pro Ser Thr Asp Leu Leu Glu Asp Leu Ser Glu Ser Arg Glu Cys 
    370                 375                 380                 
Val Asn Cys Gly Ser Ile Gln Thr Pro Leu Trp Arg Arg Asp Gly Thr 
385                 390                 395                 400 
Gly His Tyr Leu Cys Asn Ala Cys Gly Leu Tyr Ser Lys Met Asn Gly 
                405                 410                 415     
Leu Ser Arg Pro Leu Ile Lys Pro Gln Lys Arg Val Pro Ser Ser Arg 
            420                 425                 430         
Arg Leu Gly Leu Ser Cys Ala Asn Cys His Thr Thr Thr Thr Thr Leu 
        435                 440                 445             
Trp Arg Arg Asn Ala Glu Gly Glu Pro Val Cys Asn Ala Cys Gly Leu 
    450                 455                 460                 
Tyr Met Lys Leu His Gly Val Pro Arg Pro Leu Ala Met Lys Lys Glu 
465                 470                 475                 480 
Gly Ile Gln Thr Arg Lys Arg Lys Pro Lys Asn Ile Asn Lys Ser Lys 
                485                 490                 495     
Ala Cys Ser Gly Asn Ser Ser Gly Ser Val Pro Met Thr Pro Thr Ser 
            500                 505                 510         
Ser Ser Ser Asn Ser Asp Asp Cys Thr Lys Asn Thr Ser Pro Ser Thr 
        515                 520                 525             
Gln Ala Thr Thr Ser Gly Val Gly Ala Ser Val Met Ser Ala Val Gly 
    530                 535                 540                 
Glu Asn Ala Asn Pro Glu Asn Ser Asp Leu Lys Tyr Ser Gly Gln Asp 
545                 550                 555                 560 
Gly Leu Tyr Ile Gly Val Ser Leu Ser Ser Pro Ala Glu Val Thr Ser 
                565                 570                 575     
Ser Val Arg Gln Asp Ser Trp Cys Ala Leu Ala Leu Ala 
            580                 585                 

<210> 102
<211> 443
<212> PRT
<213> Mus musculus

<220> 
<223> Gata6-Ad

<400> 102
Met Tyr Gln Thr Leu Ala Ala Leu Ser Ser Gln Gly Pro Ala Ala Tyr 
1               5                   10                  15      
Asp Gly Ala Pro Gly Gly Phe Val His Ser Ala Ala Ala Ala Ala Ala 
            20                  25                  30          
Ala Ala Ala Ala Ala Ser Ser Pro Val Tyr Val Pro Thr Thr Arg Val 
        35                  40                  45              
Gly Ser Met Leu Ser Gly Leu Pro Tyr Leu Gln Gly Ala Gly Ser Gly 
    50                  55                  60                  
Pro Ser Asn His Ala Gly Gly Ala Gly Ala His Pro Gly Trp Ser Gln 
65                  70                  75                  80  
Ala Ser Ala Asp Ser Pro Pro Tyr Gly Gly Gly Gly Ala Ala Gly Gly 
                85                  90                  95      
Gly Ala Ala Gly Pro Gly Gly Ala Gly Ser Ala Thr Ala His Ala Ser 
            100                 105                 110         
Ala Arg Phe Pro Tyr Ser Pro Ser Pro Pro Met Ala Asn Gly Ala Ala 
        115                 120                 125             
Arg Asp Pro Gly Gly Tyr Val Ala Ala Gly Gly Thr Gly Ala Gly Ser 
    130                 135                 140                 
Val Ser Gly Gly Gly Gly Ser Leu Ala Ala Met Gly Gly Arg Glu His 
145                 150                 155                 160 
Gln Tyr Ser Ser Leu Ser Ala Ala Arg Pro Leu Asn Gly Thr Tyr His 
                165                 170                 175     
His His His His His His Pro Thr Tyr Ser Pro Tyr Met Ala Ala Pro 
            180                 185                 190         
Leu Thr Pro Ala Trp Pro Ala Gly Pro Phe Glu Thr Pro Val Leu His 
        195                 200                 205             
Ser Leu Gln Gly Arg Ala Gly Ala Pro Leu Pro Val Pro Arg Gly Pro 
    210                 215                 220                 
Ser Thr Asp Leu Leu Glu Asp Leu Ser Glu Ser Arg Glu Cys Val Asn 
225                 230                 235                 240 
Cys Gly Ser Ile Gln Thr Pro Leu Trp Arg Arg Asp Gly Thr Gly His 
                245                 250                 255     
Tyr Leu Cys Asn Ala Cys Gly Leu Tyr Ser Lys Met Asn Gly Leu Ser 
            260                 265                 270         
Arg Pro Leu Ile Lys Pro Gln Lys Arg Val Pro Ser Ser Arg Arg Leu 
        275                 280                 285             
Gly Leu Ser Cys Ala Asn Cys His Thr Thr Thr Thr Thr Leu Trp Arg 
    290                 295                 300                 
Arg Asn Ala Glu Gly Glu Pro Val Cys Asn Ala Cys Gly Leu Tyr Met 
305                 310                 315                 320 
Lys Leu His Gly Val Pro Arg Pro Leu Ala Met Lys Lys Glu Gly Ile 
                325                 330                 335     
Gln Thr Arg Lys Arg Lys Pro Lys Asn Ile Asn Lys Ser Lys Ala Cys 
            340                 345                 350         
Ser Gly Asn Ser Ser Gly Ser Val Pro Met Thr Pro Thr Ser Ser Ser 
        355                 360                 365             
Ser Asn Ser Asp Asp Cys Thr Lys Asn Thr Ser Pro Ser Thr Gln Ala 
    370                 375                 380                 
Thr Thr Ser Gly Val Gly Ala Ser Val Met Ser Ala Val Gly Glu Asn 
385                 390                 395                 400 
Ala Asn Pro Glu Asn Ser Asp Leu Lys Tyr Ser Gly Gln Asp Gly Leu 
                405                 410                 415     
Tyr Ile Gly Val Ser Leu Ser Ser Pro Ala Glu Val Thr Ser Ser Val 
            420                 425                 430         
Arg Gln Asp Ser Trp Cys Ala Leu Ala Leu Ala 
        435                 440             

<210> 103
<211> 372
<212> PRT
<213> Mus musculus

<220> 
<223> Nkx2-1-Em

<400> 103
Met Ser Met Ser Pro Lys His Thr Thr Pro Phe Ser Val Ser Asp Ile 
1               5                   10                  15      
Leu Ser Pro Leu Glu Glu Ser Tyr Lys Lys Val Gly Met Glu Gly Gly 
            20                  25                  30          
Gly Leu Gly Ala Pro Leu Ala Ala Tyr Arg Gln Gly Gln Ala Ala Pro 
        35                  40                  45              
Pro Ala Ala Ala Met Gln Gln His Ala Val Gly His His Gly Ala Val 
    50                  55                  60                  
Thr Ala Ala Tyr His Met Thr Ala Ala Gly Val Pro Gln Leu Ser His 
65                  70                  75                  80  
Ser Ala Val Gly Gly Tyr Cys Asn Gly Asn Leu Gly Asn Met Ser Glu 
                85                  90                  95      
Leu Pro Pro Tyr Gln Asp Thr Met Arg Asn Ser Ala Ser Gly Pro Gly 
            100                 105                 110         
Trp Tyr Gly Ala Asn Pro Asp Pro Arg Phe Pro Ala Ile Ser Arg Phe 
        115                 120                 125             
Met Gly Pro Ala Ser Gly Met Asn Met Ser Gly Met Gly Gly Leu Gly 
    130                 135                 140                 
Ser Leu Gly Asp Val Ser Lys Asn Met Ala Pro Leu Pro Ser Ala Pro 
145                 150                 155                 160 
Arg Arg Lys Arg Arg Val Leu Phe Ser Gln Ala Gln Val Tyr Glu Leu 
                165                 170                 175     
Glu Arg Arg Phe Lys Gln Gln Lys Tyr Leu Ser Ala Pro Glu Arg Glu 
            180                 185                 190         
His Leu Ala Ser Met Ile His Leu Thr Pro Thr Gln Val Lys Ile Trp 
        195                 200                 205             
Phe Gln Asn His Arg Tyr Lys Met Lys Arg Gln Ala Lys Asp Lys Ala 
    210                 215                 220                 
Ala Gln Gln Gln Leu Gln Gln Asp Ser Gly Gly Gly Gly Gly Gly Gly 
225                 230                 235                 240 
Gly Gly Ala Gly Cys Pro Gln Gln Gln Gln Ala Gln Gln Gln Ser Pro 
                245                 250                 255     
Arg Arg Val Ala Val Pro Val Leu Val Lys Asp Gly Lys Pro Cys Gln 
            260                 265                 270         
Ala Gly Ala Pro Ala Pro Gly Ala Ala Ser Leu Gln Ser His Ala Gln 
        275                 280                 285             
Gln Gln Ala Gln Gln Gln Ala Gln Ala Ala Gln Ala Ala Ala Ala Ala 
    290                 295                 300                 
Ile Ser Val Gly Ser Gly Gly Ala Gly Leu Gly Ala His Pro Gly His 
305                 310                 315                 320 
Gln Pro Gly Ser Ala Gly Gln Ser Pro Asp Leu Ala His His Ala Ala 
                325                 330                 335     
Ser Pro Ala Gly Leu Gln Gly Gln Val Ser Ser Leu Ser His Leu Asn 
            340                 345                 350         
Ser Ser Gly Ser Asp Tyr Gly Ala Met Ser Cys Ser Thr Leu Leu Tyr 
        355                 360                 365             
Gly Arg Thr Trp 
    370         

<210> 104
<211> 465
<212> PRT
<213> Mus musculus

<220> 
<223> Foxa2-Var1

<400> 104
Met His Ser Ala Ser Ser Met Leu Gly Ala Val Lys Met Glu Gly His 
1               5                   10                  15      
Glu Pro Ser Asp Trp Ser Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser 
            20                  25                  30          
Ser Val Ser Asn Met Asn Ala Gly Leu Gly Met Asn Gly Met Asn Thr 
        35                  40                  45              
Tyr Met Ser Met Ser Ala Ala Ala Met Gly Gly Gly Ser Gly Asn Met 
    50                  55                  60                  
Ser Ala Gly Ser Met Asn Met Ser Ser Tyr Val Gly Ala Gly Met Ser 
65                  70                  75                  80  
Pro Ser Leu Ala Gly Met Ser Pro Gly Ala Gly Ala Met Ala Gly Met 
                85                  90                  95      
Ser Gly Ser Ala Gly Ala Ala Gly Val Ala Gly Met Gly Pro His Leu 
            100                 105                 110         
Ser Pro Ser Leu Ser Pro Leu Gly Gly Gln Ala Ala Gly Ala Met Gly 
        115                 120                 125             
Gly Leu Ala Pro Tyr Ala Asn Met Asn Ser Met Ser Pro Met Tyr Gly 
    130                 135                 140                 
Gln Ala Gly Leu Ser Arg Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser 
145                 150                 155                 160 
Tyr Thr His Ala Lys Pro Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met 
                165                 170                 175     
Ala Ile Gln Gln Ser Pro Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr 
            180                 185                 190         
Gln Trp Ile Met Asp Leu Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg 
        195                 200                 205             
Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe Asn Asp Cys Phe Leu 
    210                 215                 220                 
Lys Val Pro Arg Ser Pro Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr 
225                 230                 235                 240 
Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg 
                245                 250                 255     
Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala 
            260                 265                 270         
Ala Gly Ala Ala Ser Ser Gly Gly Lys Lys Thr Ala Pro Gly Ser Gln 
        275                 280                 285             
Ala Ser Gln Ala Gln Leu Gly Glu Ala Ala Gly Ser Ala Ser Glu Thr 
    290                 295                 300                 
Pro Ala Gly Thr Glu Ser Pro His Ser Ser Ala Ser Pro Cys Gln Glu 
305                 310                 315                 320 
His Lys Arg Gly Gly Leu Ser Glu Leu Lys Gly Ala Pro Ala Ser Ala 
                325                 330                 335     
Leu Ser Pro Pro Glu Pro Ala Pro Ser Pro Gly Gln Gln Gln Gln Ala 
            340                 345                 350         
Ala Ala His Leu Leu Gly Pro Pro His His Pro Gly Leu Pro Pro Glu 
        355                 360                 365             
Ala His Leu Lys Pro Glu His His Tyr Ala Phe Asn His Pro Phe Ser 
    370                 375                 380                 
Ile Asn Asn Leu Met Ser Ser Glu Gln Gln His His His Ser His His 
385                 390                 395                 400 
His His Gln Pro His Lys Met Asp Leu Lys Ala Tyr Glu Gln Val Met 
                405                 410                 415     
His Tyr Pro Gly Gly Tyr Gly Ser Pro Met Pro Gly Ser Leu Ala Met 
            420                 425                 430         
Gly Pro Val Thr Asn Lys Ala Gly Leu Asp Ala Ser Pro Leu Ala Ala 
        435                 440                 445             
Asp Thr Ser Tyr Tyr Gln Gly Val Tyr Ser Arg Pro Ile Met Asn Ser 
    450                 455                 460                 
Ser 
465 

<210> 105
<211> 459
<212> PRT
<213> Mus musculus

<220> 
<223> Foxa2-Var2

<400> 105
Met Leu Gly Ala Val Lys Met Glu Gly His Glu Pro Ser Asp Trp Ser 
1               5                   10                  15      
Ser Tyr Tyr Ala Glu Pro Glu Gly Tyr Ser Ser Val Ser Asn Met Asn 
            20                  25                  30          
Ala Gly Leu Gly Met Asn Gly Met Asn Thr Tyr Met Ser Met Ser Ala 
        35                  40                  45              
Ala Ala Met Gly Gly Gly Ser Gly Asn Met Ser Ala Gly Ser Met Asn 
    50                  55                  60                  
Met Ser Ser Tyr Val Gly Ala Gly Met Ser Pro Ser Leu Ala Gly Met 
65                  70                  75                  80  
Ser Pro Gly Ala Gly Ala Met Ala Gly Met Ser Gly Ser Ala Gly Ala 
                85                  90                  95      
Ala Gly Val Ala Gly Met Gly Pro His Leu Ser Pro Ser Leu Ser Pro 
            100                 105                 110         
Leu Gly Gly Gln Ala Ala Gly Ala Met Gly Gly Leu Ala Pro Tyr Ala 
        115                 120                 125             
Asn Met Asn Ser Met Ser Pro Met Tyr Gly Gln Ala Gly Leu Ser Arg 
    130                 135                 140                 
Ala Arg Asp Pro Lys Thr Tyr Arg Arg Ser Tyr Thr His Ala Lys Pro 
145                 150                 155                 160 
Pro Tyr Ser Tyr Ile Ser Leu Ile Thr Met Ala Ile Gln Gln Ser Pro 
                165                 170                 175     
Asn Lys Met Leu Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu 
            180                 185                 190         
Phe Pro Phe Tyr Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg 
        195                 200                 205             
His Ser Leu Ser Phe Asn Asp Cys Phe Leu Lys Val Pro Arg Ser Pro 
    210                 215                 220                 
Asp Lys Pro Gly Lys Gly Ser Phe Trp Thr Leu His Pro Asp Ser Gly 
225                 230                 235                 240 
Asn Met Phe Glu Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys 
                245                 250                 255     
Cys Glu Lys Gln Leu Ala Leu Lys Glu Ala Ala Gly Ala Ala Ser Ser 
            260                 265                 270         
Gly Gly Lys Lys Thr Ala Pro Gly Ser Gln Ala Ser Gln Ala Gln Leu 
        275                 280                 285             
Gly Glu Ala Ala Gly Ser Ala Ser Glu Thr Pro Ala Gly Thr Glu Ser 
    290                 295                 300                 
Pro His Ser Ser Ala Ser Pro Cys Gln Glu His Lys Arg Gly Gly Leu 
305                 310                 315                 320 
Ser Glu Leu Lys Gly Ala Pro Ala Ser Ala Leu Ser Pro Pro Glu Pro 
                325                 330                 335     
Ala Pro Ser Pro Gly Gln Gln Gln Gln Ala Ala Ala His Leu Leu Gly 
            340                 345                 350         
Pro Pro His His Pro Gly Leu Pro Pro Glu Ala His Leu Lys Pro Glu 
        355                 360                 365             
His His Tyr Ala Phe Asn His Pro Phe Ser Ile Asn Asn Leu Met Ser 
    370                 375                 380                 
Ser Glu Gln Gln His His His Ser His His His His Gln Pro His Lys 
385                 390                 395                 400 
Met Asp Leu Lys Ala Tyr Glu Gln Val Met His Tyr Pro Gly Gly Tyr 
                405                 410                 415     
Gly Ser Pro Met Pro Gly Ser Leu Ala Met Gly Pro Val Thr Asn Lys 
            420                 425                 430         
Ala Gly Leu Asp Ala Ser Pro Leu Ala Ala Asp Thr Ser Tyr Tyr Gln 
        435                 440                 445             
Gly Val Tyr Ser Arg Pro Ile Met Asn Ser Ser 
    450                 455                 

<210> 106
<211> 134
<212> PRT
<213> Mus musculus

<220> 
<223> Id2-Var1

<400> 106
Met Lys Ala Phe Ser Pro Val Arg Ser Val Arg Lys Asn Ser Leu Ser 
1               5                   10                  15      
Asp His Ser Leu Gly Ile Ser Arg Ser Lys Thr Pro Val Asp Asp Pro 
            20                  25                  30          
Met Ser Leu Leu Tyr Asn Met Asn Asp Cys Tyr Ser Lys Leu Lys Glu 
        35                  40                  45              
Leu Val Pro Ser Ile Pro Gln Asn Lys Lys Val Thr Lys Met Glu Ile 
    50                  55                  60                  
Leu Gln His Val Ile Asp Tyr Ile Leu Asp Leu Gln Ile Ala Leu Asp 
65                  70                  75                  80  
Ser His Pro Thr Ile Val Ser Leu His His Gln Arg Pro Gly Gln Asn 
                85                  90                  95      
Gln Ala Ser Arg Thr Pro Leu Thr Thr Leu Asn Thr Asp Ile Ser Ile 
            100                 105                 110         
Leu Ser Leu Gln Ala Ser Glu Phe Pro Ser Glu Leu Met Ser Asn Asp 
        115                 120                 125             
Ser Lys Val Leu Cys Gly 
    130                 

<210> 107
<211> 155
<212> PRT
<213> Mus musculus

<220> 
<223> Id2-Var2

<400> 107
Met Lys Ala Phe Ser Pro Val Arg Ser Val Arg Lys Asn Ser Leu Ser 
1               5                   10                  15      
Asp His Ser Leu Gly Ile Ser Arg Ser Lys Thr Pro Val Asp Asp Pro 
            20                  25                  30          
Met Ser Leu Leu Tyr Asn Met Asn Asp Cys Tyr Ser Lys Leu Lys Glu 
        35                  40                  45              
Leu Val Pro Ser Ile Pro Gln Asn Lys Lys Val Thr Lys Met Glu Ile 
    50                  55                  60                  
Leu Gln His Val Ile Asp Tyr Ile Leu Asp Leu Gln Ile Ala Leu Asp 
65                  70                  75                  80  
Ser His Pro Thr Ile Val Ser Leu His His Gln Arg Pro Gly Gln Asn 
                85                  90                  95      
Gln Ala Ser Arg Thr Pro Leu Thr Thr Leu Asn Thr Asp Ile Ser Ile 
            100                 105                 110         
Leu Ser Leu Gln Val Arg Leu Ala Cys Lys Tyr Ala Thr Ala Gln Thr 
        115                 120                 125             
Leu Arg Val Ser Arg Ala Val Thr Leu Lys Ala His Arg Arg Asp Arg 
    130                 135                 140                 
Phe Ile Asn Phe Ile Phe Glu Glu Thr Val Tyr 
145                 150                 155 

<210> 108
<211> 2977
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2977
<223> /mol_type="unassigned DNA"
      /note="integrin beta 2"
      /organism="Homo sapiens"

<400> 108
gggccgctct ctgacatcag agctgctgta gagcggagag gggcaggggt gaagggccac      60

ggtggtgcaa cccaccactt cctccaagga ggagctgaga ggaacaggaa gtgtcaggac     120

tttacgaccc gcgcctccag ctgaggtttc tagacgtgac ccagggcaga ctggtagcaa     180

agcccccacg cccagccagg agcaccgccg aggactccag cacaccgagg gacatgctgg     240

gcctgcgccc cccactgctc gccctggtgg ggctgctctc cctcgggtgc gtcctctctc     300

aggagtgcac gaagttcaag gtcagcagct gccgggaatg catcgagtcg gggcccggct     360

gcacctggtg ccagaagctg aacttcacag ggccggggga tcctgactcc attcgctgcg     420

acacccggcc acagctgctc atgaggggct gtgcggctga cgacatcatg gaccccacaa     480

gcctcgctga aacccaggaa gaccacaatg ggggccagaa gcagctgtcc ccacaaaaag     540

tgacgcttta cctgcgacca ggccaggcag cagcgttcaa cgtgaccttc cggcgggcca     600

agggctaccc catcgacctg tactatctga tggacctctc ctactccatg cttgatgacc     660

tcaggaatgt caagaagcta ggtggcgacc tgctccgggc cctcaacgag atcaccgagt     720

ccggccgcat tggcttcggg tccttcgtgg acaagaccgt gctgccgttc gtgaacacgc     780

accctgataa gctgcgaaac ccatgcccca acaaggagaa agagtgccag cccccgtttg     840

ccttcaggca cgtgctgaag ctgaccaaca actccaacca gtttcagacc gaggtcggga     900

agcagctgat ttccggaaac ctggatgcac ccgagggtgg gctggacgcc atgatgcagg     960

tcgccgcctg cccggaggaa atcggctggc gcaacgtcac gcggctgctg gtgtttgcca    1020

ctgatgacgg cttccatttc gcgggcgacg ggaagctggg cgccatcctg acccccaacg    1080

acggccgctg tcacctggag gacaacttgt acaagaggag caacgaattc gactacccat    1140

cggtgggcca gctggcgcac aagctggctg aaaacaacat ccagcccatc ttcgcggtga    1200

ccagtaggat ggtgaagacc tacgagaaac tcaccgagat catccccaag tcagccgtgg    1260

gggagctgtc tgaggactcc agcaatgtgg tccaactcat taagaatgct tacaataaac    1320

tctcctccag ggtcttcctg gatcacaacg ccctccccga caccctgaaa gtcacctacg    1380

actccttctg cagcaatgga gtgacgcaca ggaaccagcc cagaggtgac tgtgatggcg    1440

tgcagatcaa tgtcccgatc accttccagg tgaaggtcac ggccacagag tgcatccagg    1500

agcagtcgtt tgtcatccgg gcgctgggct tcacggacat agtgaccgtg caggttcttc    1560

cccagtgtga gtgccggtgc cgggaccaga gcagagaccg cagcctctgc catggcaagg    1620

gcttcttgga gtgcggcatc tgcaggtgtg acactggcta cattgggaaa aactgtgagt    1680

gccagacaca gggccggagc agccaggagc tggaaggaag ctgccggaag gacaacaact    1740

ccatcatctg ctcagggctg ggggactgtg tctgcgggca gtgcctgtgc cacaccagcg    1800

acgtccccgg caagctgata tacgggcagt actgcgagtg tgacaccatc aactgtgagc    1860

gctacaacgg ccaggtctgc ggcggcccgg ggagggggct ctgcttctgc gggaagtgcc    1920

gctgccaccc gggctttgag ggctcagcgt gccagtgcga gaggaccact gagggctgcc    1980

tgaacccgcg gcgtgttgag tgtagtggtc gtggccggtg ccgctgcaac gtatgcgagt    2040

gccattcagg ctaccagctg cctctgtgcc aggagtgccc cggctgcccc tcaccctgtg    2100

gcaagtacat ctcctgcgcc gagtgcctga agttcgaaaa gggccccttt gggaagaact    2160

gcagcgcggc gtgtccgggc ctgcagctgt cgaacaaccc cgtgaagggc aggacctgca    2220

aggagaggga ctcagagggc tgctgggtgg cctacacgct ggagcagcag gacgggatgg    2280

accgctacct catctatgtg gatgagagcc gagagtgtgt ggcaggcccc aacatcgccg    2340

ccatcgtcgg gggcaccgtg gcaggcatcg tgctgatcgg cattctcctg ctggtcatct    2400

ggaaggctct gatccacctg agcgacctcc gggagtacag gcgctttgag aaggagaagc    2460

tcaagtccca gtggaacaat gataatcccc ttttcaagag cgccaccacg acggtcatga    2520

accccaagtt tgctgagagt taggagcact tggtgaagac aaggccgtca ggacccacca    2580

tgtctgcccc atcacgcggc cgagacatgg cttgccacag ctcttgagga tgtcaccaat    2640

taaccagaaa tccagttatt ttccgccctc aaaatgacag ccatggccgg ccgggtgctt    2700

ctgggggctc gtcgggggga cagctccact ctgactggca cagtctttgc atggagactt    2760

gaggagggag ggcttgaggt tggtgaggtt aggtgcgtgt ttcctgtgca agtcaggaca    2820

tcagtctgat taaaggtggt gccaatttat ttacatttaa acttgtcagg gtataaaatg    2880

acatcccatt aattatattg ttaatcaatc acgtgtatag aaaaaaaata aaacttcaat    2940

acaggctgtc catggaaaaa aaaaaaaaaa aaaaaaa                             2977


<210> 109
<211> 2932
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2932
<223> /mol_type="unassigned DNA"
      /note="integrin beta 2, transcript variant 2 (NM_001127491)"     
      /organism="Homo sapiens"

<400> 109
atccagggtg aggaaggcag cccacacttt tcttggagac acatccccaa agaagtcctc      60

acgtggctcc gtttgggcag aaaccatgaa ttgaacggga aaagaaatat gtcaagtatc     120

agaaagaaga gtggcatgct ttgacagcaa gtggactccg agtccagggc agagcctcag     180

ttagggacat gctgggcctg cgccccccac tgctcgccct ggtggggctg ctctccctcg     240

ggtgcgtcct ctctcaggag tgcacgaagt tcaaggtcag cagctgccgg gaatgcatcg     300

agtcggggcc cggctgcacc tggtgccaga agctgaactt cacagggccg ggggatcctg     360

actccattcg ctgcgacacc cggccacagc tgctcatgag gggctgtgcg gctgacgaca     420

tcatggaccc cacaagcctc gctgaaaccc aggaagacca caatgggggc cagaagcagc     480

tgtccccaca aaaagtgacg ctttacctgc gaccaggcca ggcagcagcg ttcaacgtga     540

ccttccggcg ggccaagggc taccccatcg acctgtacta tctgatggac ctctcctact     600

ccatgcttga tgacctcagg aatgtcaaga agctaggtgg cgacctgctc cgggccctca     660

acgagatcac cgagtccggc cgcattggct tcgggtcctt cgtggacaag accgtgctgc     720

cgttcgtgaa cacgcaccct gataagctgc gaaacccatg ccccaacaag gagaaagagt     780

gccagccccc gtttgccttc aggcacgtgc tgaagctgac caacaactcc aaccagtttc     840

agaccgaggt cgggaagcag ctgatttccg gaaacctgga tgcacccgag ggtgggctgg     900

acgccatgat gcaggtcgcc gcctgcccgg aggaaatcgg ctggcgcaac gtcacgcggc     960

tgctggtgtt tgccactgat gacggcttcc atttcgcggg cgacgggaag ctgggcgcca    1020

tcctgacccc caacgacggc cgctgtcacc tggaggacaa cttgtacaag aggagcaacg    1080

aattcgacta cccatcggtg ggccagctgg cgcacaagct ggctgaaaac aacatccagc    1140

ccatcttcgc ggtgaccagt aggatggtga agacctacga gaaactcacc gagatcatcc    1200

ccaagtcagc cgtgggggag ctgtctgagg actccagcaa tgtggtccaa ctcattaaga    1260

atgcttacaa taaactctcc tccagggtct tcctggatca caacgccctc cccgacaccc    1320

tgaaagtcac ctacgactcc ttctgcagca atggagtgac gcacaggaac cagcccagag    1380

gtgactgtga tggcgtgcag atcaatgtcc cgatcacctt ccaggtgaag gtcacggcca    1440

cagagtgcat ccaggagcag tcgtttgtca tccgggcgct gggcttcacg gacatagtga    1500

ccgtgcaggt tcttccccag tgtgagtgcc ggtgccggga ccagagcaga gaccgcagcc    1560

tctgccatgg caagggcttc ttggagtgcg gcatctgcag gtgtgacact ggctacattg    1620

ggaaaaactg tgagtgccag acacagggcc ggagcagcca ggagctggaa ggaagctgcc    1680

ggaaggacaa caactccatc atctgctcag ggctggggga ctgtgtctgc gggcagtgcc    1740

tgtgccacac cagcgacgtc cccggcaagc tgatatacgg gcagtactgc gagtgtgaca    1800

ccatcaactg tgagcgctac aacggccagg tctgcggcgg cccggggagg gggctctgct    1860

tctgcgggaa gtgccgctgc cacccgggct ttgagggctc agcgtgccag tgcgagagga    1920

ccactgaggg ctgcctgaac ccgcggcgtg ttgagtgtag tggtcgtggc cggtgccgct    1980

gcaacgtatg cgagtgccat tcaggctacc agctgcctct gtgccaggag tgccccggct    2040

gcccctcacc ctgtggcaag tacatctcct gcgccgagtg cctgaagttc gaaaagggcc    2100

cctttgggaa gaactgcagc gcggcgtgtc cgggcctgca gctgtcgaac aaccccgtga    2160

agggcaggac ctgcaaggag agggactcag agggctgctg ggtggcctac acgctggagc    2220

agcaggacgg gatggaccgc tacctcatct atgtggatga gagccgagag tgtgtggcag    2280

gccccaacat cgccgccatc gtcgggggca ccgtggcagg catcgtgctg atcggcattc    2340

tcctgctggt catctggaag gctctgatcc acctgagcga cctccgggag tacaggcgct    2400

ttgagaagga gaagctcaag tcccagtgga acaatgataa tccccttttc aagagcgcca    2460

ccacgacggt catgaacccc aagtttgctg agagttagga gcacttggtg aagacaaggc    2520

cgtcaggacc caccatgtct gccccatcac gcggccgaga catggcttgc cacagctctt    2580

gaggatgtca ccaattaacc agaaatccag ttattttccg ccctcaaaat gacagccatg    2640

gccggccggg tgcttctggg ggctcgtcgg ggggacagct ccactctgac tggcacagtc    2700

tttgcatgga gacttgagga gggagggctt gaggttggtg aggttaggtg cgtgtttcct    2760

gtgcaagtca ggacatcagt ctgattaaag gtggtgccaa tttatttaca tttaaacttg    2820

tcagggtata aaatgacatc ccattaatta tattgttaat caatcacgtg tatagaaaaa    2880

aaataaaact tcaatacagg ctgtccatgg aaaaaaaaaa aaaaaaaaaa aa            2932


<210> 110
<211> 769
<212> PRT
<213> Homo sapiens

<220> 
<223> ITGB2, integrin beta 2


<400> 110
Met Leu Gly Leu Arg Pro Pro Leu Leu Ala Leu Val Gly Leu Leu Ser 
1               5                   10                  15      
Leu Gly Cys Val Leu Ser Gln Glu Cys Thr Lys Phe Lys Val Ser Ser 
            20                  25                  30          
Cys Arg Glu Cys Ile Glu Ser Gly Pro Gly Cys Thr Trp Cys Gln Lys 
        35                  40                  45              
Leu Asn Phe Thr Gly Pro Gly Asp Pro Asp Ser Ile Arg Cys Asp Thr 
    50                  55                  60                  
Arg Pro Gln Leu Leu Met Arg Gly Cys Ala Ala Asp Asp Ile Met Asp 
65                  70                  75                  80  
Pro Thr Ser Leu Ala Glu Thr Gln Glu Asp His Asn Gly Gly Gln Lys 
                85                  90                  95      
Gln Leu Ser Pro Gln Lys Val Thr Leu Tyr Leu Arg Pro Gly Gln Ala 
            100                 105                 110         
Ala Ala Phe Asn Val Thr Phe Arg Arg Ala Lys Gly Tyr Pro Ile Asp 
        115                 120                 125             
Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Leu Asp Asp Leu Arg 
    130                 135                 140                 
Asn Val Lys Lys Leu Gly Gly Asp Leu Leu Arg Ala Leu Asn Glu Ile 
145                 150                 155                 160 
Thr Glu Ser Gly Arg Ile Gly Phe Gly Ser Phe Val Asp Lys Thr Val 
                165                 170                 175     
Leu Pro Phe Val Asn Thr His Pro Asp Lys Leu Arg Asn Pro Cys Pro 
            180                 185                 190         
Asn Lys Glu Lys Glu Cys Gln Pro Pro Phe Ala Phe Arg His Val Leu 
        195                 200                 205             
Lys Leu Thr Asn Asn Ser Asn Gln Phe Gln Thr Glu Val Gly Lys Gln 
    210                 215                 220                 
Leu Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Leu Asp Ala Met 
225                 230                 235                 240 
Met Gln Val Ala Ala Cys Pro Glu Glu Ile Gly Trp Arg Asn Val Thr 
                245                 250                 255     
Arg Leu Leu Val Phe Ala Thr Asp Asp Gly Phe His Phe Ala Gly Asp 
            260                 265                 270         
Gly Lys Leu Gly Ala Ile Leu Thr Pro Asn Asp Gly Arg Cys His Leu 
        275                 280                 285             
Glu Asp Asn Leu Tyr Lys Arg Ser Asn Glu Phe Asp Tyr Pro Ser Val 
    290                 295                 300                 
Gly Gln Leu Ala His Lys Leu Ala Glu Asn Asn Ile Gln Pro Ile Phe 
305                 310                 315                 320 
Ala Val Thr Ser Arg Met Val Lys Thr Tyr Glu Lys Leu Thr Glu Ile 
                325                 330                 335     
Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser Ser Asn Val 
            340                 345                 350         
Val Gln Leu Ile Lys Asn Ala Tyr Asn Lys Leu Ser Ser Arg Val Phe 
        355                 360                 365             
Leu Asp His Asn Ala Leu Pro Asp Thr Leu Lys Val Thr Tyr Asp Ser 
    370                 375                 380                 
Phe Cys Ser Asn Gly Val Thr His Arg Asn Gln Pro Arg Gly Asp Cys 
385                 390                 395                 400 
Asp Gly Val Gln Ile Asn Val Pro Ile Thr Phe Gln Val Lys Val Thr 
                405                 410                 415     
Ala Thr Glu Cys Ile Gln Glu Gln Ser Phe Val Ile Arg Ala Leu Gly 
            420                 425                 430         
Phe Thr Asp Ile Val Thr Val Gln Val Leu Pro Gln Cys Glu Cys Arg 
        435                 440                 445             
Cys Arg Asp Gln Ser Arg Asp Arg Ser Leu Cys His Gly Lys Gly Phe 
    450                 455                 460                 
Leu Glu Cys Gly Ile Cys Arg Cys Asp Thr Gly Tyr Ile Gly Lys Asn 
465                 470                 475                 480 
Cys Glu Cys Gln Thr Gln Gly Arg Ser Ser Gln Glu Leu Glu Gly Ser 
                485                 490                 495     
Cys Arg Lys Asp Asn Asn Ser Ile Ile Cys Ser Gly Leu Gly Asp Cys 
            500                 505                 510         
Val Cys Gly Gln Cys Leu Cys His Thr Ser Asp Val Pro Gly Lys Leu 
        515                 520                 525             
Ile Tyr Gly Gln Tyr Cys Glu Cys Asp Thr Ile Asn Cys Glu Arg Tyr 
    530                 535                 540                 
Asn Gly Gln Val Cys Gly Gly Pro Gly Arg Gly Leu Cys Phe Cys Gly 
545                 550                 555                 560 
Lys Cys Arg Cys His Pro Gly Phe Glu Gly Ser Ala Cys Gln Cys Glu 
                565                 570                 575     
Arg Thr Thr Glu Gly Cys Leu Asn Pro Arg Arg Val Glu Cys Ser Gly 
            580                 585                 590         
Arg Gly Arg Cys Arg Cys Asn Val Cys Glu Cys His Ser Gly Tyr Gln 
        595                 600                 605             
Leu Pro Leu Cys Gln Glu Cys Pro Gly Cys Pro Ser Pro Cys Gly Lys 
    610                 615                 620                 
Tyr Ile Ser Cys Ala Glu Cys Leu Lys Phe Glu Lys Gly Pro Phe Gly 
625                 630                 635                 640 
Lys Asn Cys Ser Ala Ala Cys Pro Gly Leu Gln Leu Ser Asn Asn Pro 
                645                 650                 655     
Val Lys Gly Arg Thr Cys Lys Glu Arg Asp Ser Glu Gly Cys Trp Val 
            660                 665                 670         
Ala Tyr Thr Leu Glu Gln Gln Asp Gly Met Asp Arg Tyr Leu Ile Tyr 
        675                 680                 685             
Val Asp Glu Ser Arg Glu Cys Val Ala Gly Pro Asn Ile Ala Ala Ile 
    690                 695                 700                 
Val Gly Gly Thr Val Ala Gly Ile Val Leu Ile Gly Ile Leu Leu Leu 
705                 710                 715                 720 
Val Ile Trp Lys Ala Leu Ile His Leu Ser Asp Leu Arg Glu Tyr Arg 
                725                 730                 735     
Arg Phe Glu Lys Glu Lys Leu Lys Ser Gln Trp Asn Asn Asp Asn Pro 
            740                 745                 750         
Leu Phe Lys Ser Ala Thr Thr Thr Val Met Asn Pro Lys Phe Ala Glu 
        755                 760                 765             
Ser 
    

<210> 111
<211> 5603
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..5603
<223> /mol_type="unassigned DNA"
      /note="prostaglandin I2 (prostacyclin) synthase (PTGIS)"
      /organism="Homo sapiens"

<400> 111
ggagtgggcc aggccgccag ccccgccagc cccgccagcc ccgccagccc cgcgatggct       60

tgggccgcgc tcctcggcct cctggccgca ctgttgctgc tgctgctact gagccgccgc      120

cgcacgcggc gacctggtga gcctcccctg gacctgggca gcatcccctg gttggggtat      180

gccttggact ttggaaaaga tgctgccagc ttcctcacga ggatgaagga gaagcacggt      240

gacatcttta ctatactggt tgggggcagg tatgtcaccg ttctcctgga cccacactcc      300

tacgacgcgg tggtgtggga gcctcgcacc aggctcgact tccatgccta tgccatcttc      360

ctcatggaga ggatttttga tgtgcagctt ccacattaca gccccagtga tgaaaaggcc      420

aggatgaaac tgactcttct ccacagagag ctccaggcac tcacagaagc catgtatacc      480

aacctccatg cagtgctgtt gggcgatgct acagaagcag gcagtggctg gcacgagatg      540

ggtctcctcg acttctccta cagcttcctg ctcagagccg gctacctgac tctttacgga      600

attgaggcgc tgccacgcac ccatgaaagc caggcccagg accgcgtcca ctcagctgat      660

gtcttccaca cctttcgcca gctcgaccgg ctgctcccca aactggcccg tggctccctg      720

tcagtggggg acaaggacca catgtgcagt gtcaaaagtc gcctgtggaa gctgctatcc      780

ccagccaggc tggccaggcg ggcccaccgg agcaaatggc tggagagtta cctgctgcac      840

ctggaggaga tgggtgtgtc agaggagatg caggcacggg ccctggtgct gcagctgtgg      900

gccacacagg ggaatatggg tcccgctgcc ttctggctcc tgctcttcct tctcaagaat      960

cctgaagccc tggctgctgt ccgcggagag ctcgagagta tcctttggca agcggagcag     1020

cctgtctcgc agacgaccac tctcccacag aaggttctag acagcacacc tgtgcttgat     1080

agcgtgctga gtgagagcct caggcttaca gctgccccct tcatcacccg cgaggttgtg     1140

gtggacctgg ccatgcccat ggcagacggg cgagaattca acctgcgacg tggtgaccgc     1200

ctcctcctct tccccttcct gagcccccag agagacccag aaatctacac agacccagag     1260

gtatttaaat acaaccgatt cctgaaccct gacggatcag agaagaaaga cttttacaag     1320

gatgggaaac ggctgaagaa ttacaacatg ccctgggggg cggggcacaa tcactgcctg     1380

gggaggagtt atgcggtcaa cagcatcaaa caatttgtgt tccttgtgct ggtgcacttg     1440

gacttggagc tgatcaacgc agatgtggag atccctgagt ttgacctcag caggtacggc     1500

ttcggtctga tgcagccgga acacgacgtg cccgtccgct accgcatccg cccatgacac     1560

agggagcaga tggatccacg tgctcgcctc tgcccagcct gccccagcct gccccagcct     1620

cccagctttc tgtgtgcaca gttggcccgg gtgcaggtgc tagcattacc acttccctgc     1680

ttttctccca gaaggctggg tccaggggag ggaaaagcta agagggtgaa caaagaaaag     1740

acattgaaag ctctatggat tatccactgc aaagttttct ttccaaaatc aggctttgtc     1800

tgctcccaat tcacctcgtt actctcacct cgtgatatcc acaaatgcta ttcagataag     1860

gcagaactag gagtcttcac tgctctgccc ccaactcccg gaggtgtcac cttcctagtt     1920

cttatgagct agcatggccc gggccttatc cagtcaaagc ggatgctggc cacagaaagg     1980

ccactcagga tgtcctttgt gtccattgat gtcattcagc agtcagtccc ccaataatcc     2040

ttaaactagc taaaaccaaa ggagtccctt agaagatctg cttccctggg gccccatttg     2100

ccagattgcc ccattgctca cactacttga gaaaatgcag gagagcttcc cccaaggctg     2160

atgcattccc ggtgcagaac aggggcaccc tccaaacact gggctctgag gagtggagtt     2220

ctctgttcta gagtgacagg caccagatgg gatgggcttt ctcagtgtca gcactcaggt     2280

agggagctaa ggaagacaca gcccagacaa gatggctgga aggagccagc caggactcct     2340

tagactgatc aagccaaaaa agaaggtgcc gatttcatgc attctagtgc agaagcccca     2400

actgtgatca cgatccagtc tgcagacgtg ttttgtttgg acttcactta aaaaaatgcc     2460

ttagttgtta tcatctttgg gagagttcat tcaaaatgtc cagcttctct tgaaaacttg     2520

gtatatctgg ccacactggg ctcacattcc caagggtaac tcttggccag agctgagtgg     2580

cagccgcctc ccttatgcag gacatgtgct ctcggcttca ccagggttct gaccgggtct     2640

gcttctgcat tcacagcgcc tcctggacct gaaggcatct gagtgtgaga ccctgttcta     2700

actcttagaa gtgacattgt aagaggtggt ggggaccagc taattggtcc aacccagcct     2760

gagtgcacca ccctttgaac aaatgtatca gtgatgaaaa tttgcctttg ccccggcttg     2820

cctgtaatcc cagcactttg ggaggccgag gtgggcggat cacttgaggt cgggagttca     2880

agaccagcct ggccaacatg gcgaaacccc gtctctacta aacataaaaa aattagtcag     2940

gtgtggcggt gcgtgcctgt aatcccagct attcaggagg ctgaggcacc agaattgctt     3000

gaacccagga ggtggaggtt gcagtgaact gagactgcgc cacggcactc cagcctgggc     3060

gacagagcaa gactctgtct caataaataa ataattaatt aaaataaaaa acagcttaaa     3120

gagaaaaatg gcctgcaaac cttttttatg atgctatttt tattaatata aagtcctgtt     3180

tattgagacc ctttaaatgc ctgcgagaga ccctacagac agtatgtcta ctcctcacag     3240

catctctatg aagagaagga gggttgtgcc cacttcatag atgagaaaac tgagaggtga     3300

ggtgacttgc ctggggccac atagctcata agctgtagaa ctctgcaggc agatttactg     3360

tcccaggagc aaatgctgga tgagcaactc ctgttctttg ggctcaaggg gactggtgat     3420

gggacaattc ttctcgactt caggagctga cagagccaga ggcacctaaa cttgggtaca     3480

tcttgtaaga cacataatga ggtccctcta gctttagctg gagggagata aaagaacccc     3540

agacctctga atgtcccaga ggctagtctc ttctcagagc agcactgggg tttgggggct     3600

tccctgggcc tcagcctcca ggcaccccca ggattcccag agagacgctg tgattggcag     3660

gaggcaggat atccccaggg aaacccatct tcacgcctgg gtgaccccca ctgccgcctc     3720

cttcttaact ctgcaggaaa tcagagctgg cagcctccag tgggaggaca gagccggttt     3780

ccgtggcaac cctcagctgc ctcatcgtgg ctgggaaggg aaggaagcaa gccggcagaa     3840

atagctatgg aaggtcttgc gcaggctgca accctggtgt gctgggcgaa aacccttatg     3900

actcccccct tccaaatcag gctgggttgt cactgagact agattctcac ctgccttcaa     3960

agaagggcca attcccttta aaggtcgcac ctccttggaa ccacagtcat tagtgaatta     4020

cactcaagga aaagatgtgc tcccaccagg cagctccagc tgttacctga gatactgaag     4080

tgcagctcag gagacgatta tttaaacctg cccttgtttt aatcgttatt tttctcttta     4140

aaaaaaatag aagctataaa gaaaagaggg agagatgagt gggttagcta cctgctatgc     4200

gctagttagg aagttacctg gatgccattg tatttcttca tcccttgctt aagaatcaaa     4260

attactggac atatgttagg aatactcttt ctttctttct ttctttttaa gctcagtggc     4320

aagaatgaaa tactcttttt tttttttttt ttttgagatg gagtctcgct ctgctgccca     4380

ggctagagtg cagtggcgtg atctcggctc actgcaagct ctgcctcccg tgttcacacc     4440

attctcctgc ctcagcctcc tgagtagctg ggactacagg cacccgccac cacacccggc     4500

taatttttgg atttttagta gagatgggat ttcaccgtat tagccaggat ggtcttgatc     4560

tcctgagctc gtgatctgcc cgcctcggcc tcccaaagtg ctgggattac aggtgtgagc     4620

caccgcgccc agccaagaat aaaatactct taagttgatc taatgaagtg tttccttacc     4680

attgtgatta ttgttactat tatttgctat attttaatat tgttgtttac caaatattct     4740

cctttaaaca gactcgcttt ttaaactttt tttttttttt ttgagacgga gtttcacgct     4800

tattgcccag gctggagtgc aatggcacga tctcagctca ccacaacctc cacctcctgg     4860

gtttaagcaa tgcttctgcc tcagcttccc aagtagctga gattacaggc gcacaccacc     4920

acgcccaact gatttttgta tttttagtag agacggggtt tccccatgtt ggtcaggctg     4980

gtctcgaact cctgacctcg tgatttgcct gcctgggcct cccaaagtgc taggattaca     5040

ggcatgagcc accatgcccg gcctaaactt tgtttttaaa atgaactttt tttcccccca     5100

attgctgcca atagtggata acatgtatca ctcactgcca aaaatagaaa gtgaccatga     5160

aaaataaatt cgctggggaa gggggctcca tgctggtgtg gccaaggctg agagctctct     5220

cttctctgtt acaaaacgag ataagcaagt gttagaattg ccttaaggcc acactggcat     5280

ctccctgacc ttctccaggg acagaagcag gagtaagttt ctcatcccat gggcgaccag     5340

ggccatctcc tcccaccagt ggcccccact cacagggagc tggcaatgcc ctacctgcct     5400

gttctccaga tggagaaaca ggctctgaga tttcacaggt cttgcccaaa gtcattgatt     5460

ttgatgatta aaaagaataa acacagtgtt tcctgagtag cagtgattgt tatgccttgc     5520

tattttaata aagattctat tttcgtataa cattgtcaag tggaaacatg ctgaaatcta     5580

ttaaaccatc tttgtttgtg gaa                                             5603


<210> 112
<211> 500
<212> PRT
<213> Homo sapiens

<220> 
<223> PTGIS (prostaglandin I2 (prostacyclin) synthase (PTGIS))

<400> 112
Met Ala Trp Ala Ala Leu Leu Gly Leu Leu Ala Ala Leu Leu Leu Leu 
1               5                   10                  15      
Leu Leu Leu Ser Arg Arg Arg Thr Arg Arg Pro Gly Glu Pro Pro Leu 
            20                  25                  30          
Asp Leu Gly Ser Ile Pro Trp Leu Gly Tyr Ala Leu Asp Phe Gly Lys 
        35                  40                  45              
Asp Ala Ala Ser Phe Leu Thr Arg Met Lys Glu Lys His Gly Asp Ile 
    50                  55                  60                  
Phe Thr Ile Leu Val Gly Gly Arg Tyr Val Thr Val Leu Leu Asp Pro 
65                  70                  75                  80  
His Ser Tyr Asp Ala Val Val Trp Glu Pro Arg Thr Arg Leu Asp Phe 
                85                  90                  95      
His Ala Tyr Ala Ile Phe Leu Met Glu Arg Ile Phe Asp Val Gln Leu 
            100                 105                 110         
Pro His Tyr Ser Pro Ser Asp Glu Lys Ala Arg Met Lys Leu Thr Leu 
        115                 120                 125             
Leu His Arg Glu Leu Gln Ala Leu Thr Glu Ala Met Tyr Thr Asn Leu 
    130                 135                 140                 
His Ala Val Leu Leu Gly Asp Ala Thr Glu Ala Gly Ser Gly Trp His 
145                 150                 155                 160 
Glu Met Gly Leu Leu Asp Phe Ser Tyr Ser Phe Leu Leu Arg Ala Gly 
                165                 170                 175     
Tyr Leu Thr Leu Tyr Gly Ile Glu Ala Leu Pro Arg Thr His Glu Ser 
            180                 185                 190         
Gln Ala Gln Asp Arg Val His Ser Ala Asp Val Phe His Thr Phe Arg 
        195                 200                 205             
Gln Leu Asp Arg Leu Leu Pro Lys Leu Ala Arg Gly Ser Leu Ser Val 
    210                 215                 220                 
Gly Asp Lys Asp His Met Cys Ser Val Lys Ser Arg Leu Trp Lys Leu 
225                 230                 235                 240 
Leu Ser Pro Ala Arg Leu Ala Arg Arg Ala His Arg Ser Lys Trp Leu 
                245                 250                 255     
Glu Ser Tyr Leu Leu His Leu Glu Glu Met Gly Val Ser Glu Glu Met 
            260                 265                 270         
Gln Ala Arg Ala Leu Val Leu Gln Leu Trp Ala Thr Gln Gly Asn Met 
        275                 280                 285             
Gly Pro Ala Ala Phe Trp Leu Leu Leu Phe Leu Leu Lys Asn Pro Glu 
    290                 295                 300                 
Ala Leu Ala Ala Val Arg Gly Glu Leu Glu Ser Ile Leu Trp Gln Ala 
305                 310                 315                 320 
Glu Gln Pro Val Ser Gln Thr Thr Thr Leu Pro Gln Lys Val Leu Asp 
                325                 330                 335     
Ser Thr Pro Val Leu Asp Ser Val Leu Ser Glu Ser Leu Arg Leu Thr 
            340                 345                 350         
Ala Ala Pro Phe Ile Thr Arg Glu Val Val Val Asp Leu Ala Met Pro 
        355                 360                 365             
Met Ala Asp Gly Arg Glu Phe Asn Leu Arg Arg Gly Asp Arg Leu Leu 
    370                 375                 380                 
Leu Phe Pro Phe Leu Ser Pro Gln Arg Asp Pro Glu Ile Tyr Thr Asp 
385                 390                 395                 400 
Pro Glu Val Phe Lys Tyr Asn Arg Phe Leu Asn Pro Asp Gly Ser Glu 
                405                 410                 415     
Lys Lys Asp Phe Tyr Lys Asp Gly Lys Arg Leu Lys Asn Tyr Asn Met 
            420                 425                 430         
Pro Trp Gly Ala Gly His Asn His Cys Leu Gly Arg Ser Tyr Ala Val 
        435                 440                 445             
Asn Ser Ile Lys Gln Phe Val Phe Leu Val Leu Val His Leu Asp Leu 
    450                 455                 460                 
Glu Leu Ile Asn Ala Asp Val Glu Ile Pro Glu Phe Asp Leu Ser Arg 
465                 470                 475                 480 
Tyr Gly Phe Gly Leu Met Gln Pro Glu His Asp Val Pro Val Arg Tyr 
                485                 490                 495     
Arg Ile Arg Pro 
            500 

<210> 113
<211> 1902
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1902
<223> /mol_type="unassigned DNA"
      /note="BASP1 (brain abundant, membrane attached signal protein
      1)"
      /organism="Homo sapiens"

<400> 113
ggcactgggc aggaagggga gggggagcga gcgcgagaaa tgcagaggct gcagcggcgg      60

cggcggcggc agtagcggca gcggcgacga cggcggcggc agcgctccaa ctggctcctc     120

gctccgggct ccgccgtcga gccgggagag agcctccgcc agcggccagg caccagccag     180

acgacgccag cgaccccggc ctctcggcgg caccgcgcta actcaggggc tgcataggca     240

cccagagccg aactccaaga tgggaggcaa gctcagcaag aagaagaagg gctacaatgt     300

gaacgacgag aaagccaagg agaaagacaa gaaggccgag ggcgcggcga cggaagagga     360

ggggaccccg aaggagagtg agccccaggc ggccgcagag cccgccgagg ccaaggaggg     420

caaggagaag cccgaccagg acgccgaggg caaggccgag gagaaggagg gcgagaagga     480

cgcggcggct gccaaggagg aggccccgaa ggcggagccc gagaagacgg agggcgcggc     540

agaggccaag gctgagcccc cgaaggcgcc cgagcaggag caggcggccc ccggccccgc     600

tgcgggcggc gaggccccca aagctgctga ggccgccgcg gccccggccg agagcgcggc     660

ccctgccgcc ggggaggagc ccagcaagga ggaaggggaa cccaaaaaga ctgaggcgcc     720

cgcagctcct gccgcccagg agaccaaaag tgacggggcc ccagcttcag actcaaaacc     780

cggcagctcg gaggctgccc cctcttccaa ggagaccccc gcagccacgg aagcgcctag     840

ttccacaccc aaggcccagg gccccgcagc ctctgcagaa gagcccaagc cggtggaggc     900

cccggcagct aattccgacc aaaccgtaac cgtgaaagag tgacaaggac agcctatagg     960

aaaaacaata ccacttaaaa caatctcctc tctctctctc tctctctctc tctatctctc    1020

tctctatctc ctctctctct ctcctctcct atctctcctc tctctctctc ctatactaac    1080

ttgtttcaaa ttggaagtaa tgatatgtat tgcccaagga aaaatacagg atgttgtccc    1140

atcaagggag ggagggggtg ggagaatcca aatagtattt ttgtggggaa atatctaata    1200

taccttcagt caactttacc aagaagtcct ggatttccaa gatccgcgtc tgaaagtgca    1260

gtacatcgtt tgtacctgaa actgccgcca catgcactcc tccaccgctg agagttgaat    1320

agcttttctt ctgcaatggg agttgggagt gatgcgtttg attctgccca cagggcctgt    1380

gccaaggcaa tcagatcttt atgagagcag tattttctgt gttttctttt taatttacag    1440

cctttcttat tttgatattt ttttaatgtt gtggatgaat gccagctttc agacagagcc    1500

cacttagctt gtccacatgg atctcaatgc caatcctcca ttcttcctct ccagatattt    1560

ttgggagtga caaacattct ctcatcctac ttagcctacc tagatttctc atgacgagtt    1620

aatgcatgtc cgtggttggg tgcacctgta gttctgttta ttggtcagtg gaaatgaaaa    1680

aaaaaaaaaa aaaaagtctg cgttcattgc agttccagtt tctcttccat tctgtgtcac    1740

agacaccaac acaccactca ttggaaaatg gaaaaaaaaa acaaaaaaaa aacaaaaaaa    1800

tgtacaatgg atgcattgaa attatatgta attgtataaa tggtgcaaca gtaataaagt    1860

taaacaatta aaaagaagta ataaagacaa aaaaaaaaaa aa                       1902


<210> 114
<211> 1727
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1727
<223> /mol_type="unassigned DNA"
      /note="BASP1 (brain abundant, membrane attached signal protein
      1)"
      /organism="Homo sapiens"

<400> 114
gcgcaactcg tttgcagcgg cgcagcccag acgcgcctgc agctggggct caccccaacc      60

tcgctgccag ccgagaactc caagatggga ggcaagctca gcaagaagaa gaagggctac     120

aatgtgaacg acgagaaagc caaggagaaa gacaagaagg ccgagggcgc ggcgacggaa     180

gaggagggga ccccgaagga gagtgagccc caggcggccg cagagcccgc cgaggccaag     240

gagggcaagg agaagcccga ccaggacgcc gagggcaagg ccgaggagaa ggagggcgag     300

aaggacgcgg cggctgccaa ggaggaggcc ccgaaggcgg agcccgagaa gacggagggc     360

gcggcagagg ccaaggctga gcccccgaag gcgcccgagc aggagcaggc ggcccccggc     420

cccgctgcgg gcggcgaggc ccccaaagct gctgaggccg ccgcggcccc ggccgagagc     480

gcggcccctg ccgccgggga ggagcccagc aaggaggaag gggaacccaa aaagactgag     540

gcgcccgcag ctcctgccgc ccaggagacc aaaagtgacg gggccccagc ttcagactca     600

aaacccggca gctcggaggc tgccccctct tccaaggaga cccccgcagc cacggaagcg     660

cctagttcca cacccaaggc ccagggcccc gcagcctctg cagaagagcc caagccggtg     720

gaggccccgg cagctaattc cgaccaaacc gtaaccgtga aagagtgaca aggacagcct     780

ataggaaaaa caataccact taaaacaatc tcctctctct ctctctctct ctctctctat     840

ctctctctct atctcctctc tctctctcct ctcctatctc tcctctctct ctctcctata     900

ctaacttgtt tcaaattgga agtaatgata tgtattgccc aaggaaaaat acaggatgtt     960

gtcccatcaa gggagggagg gggtgggaga atccaaatag tatttttgtg gggaaatatc    1020

taatatacct tcagtcaact ttaccaagaa gtcctggatt tccaagatcc gcgtctgaaa    1080

gtgcagtaca tcgtttgtac ctgaaactgc cgccacatgc actcctccac cgctgagagt    1140

tgaatagctt ttcttctgca atgggagttg ggagtgatgc gtttgattct gcccacaggg    1200

cctgtgccaa ggcaatcaga tctttatgag agcagtattt tctgtgtttt ctttttaatt    1260

tacagccttt cttattttga tattttttta atgttgtgga tgaatgccag ctttcagaca    1320

gagcccactt agcttgtcca catggatctc aatgccaatc ctccattctt cctctccaga    1380

tatttttggg agtgacaaac attctctcat cctacttagc ctacctagat ttctcatgac    1440

gagttaatgc atgtccgtgg ttgggtgcac ctgtagttct gtttattggt cagtggaaat    1500

gaaaaaaaaa aaaaaaaaaa gtctgcgttc attgcagttc cagtttctct tccattctgt    1560

gtcacagaca ccaacacacc actcattgga aaatggaaaa aaaaaacaaa aaaaaaacaa    1620

aaaaatgtac aatggatgca ttgaaattat atgtaattgt ataaatggtg caacagtaat    1680

aaagttaaac aattaaaaag aagtaataaa gacaaaaaaa aaaaaaa                  1727


<210> 115
<211> 227
<212> PRT
<213> Homo sapiens

<220> 
<223> BASP1 (brain abundant, membrane attached signal protein 1)

<400> 115
Met Gly Gly Lys Leu Ser Lys Lys Lys Lys Gly Tyr Asn Val Asn Asp 
1               5                   10                  15      
Glu Lys Ala Lys Glu Lys Asp Lys Lys Ala Glu Gly Ala Ala Thr Glu 
            20                  25                  30          
Glu Glu Gly Thr Pro Lys Glu Ser Glu Pro Gln Ala Ala Ala Glu Pro 
        35                  40                  45              
Ala Glu Ala Lys Glu Gly Lys Glu Lys Pro Asp Gln Asp Ala Glu Gly 
    50                  55                  60                  
Lys Ala Glu Glu Lys Glu Gly Glu Lys Asp Ala Ala Ala Ala Lys Glu 
65                  70                  75                  80  
Glu Ala Pro Lys Ala Glu Pro Glu Lys Thr Glu Gly Ala Ala Glu Ala 
                85                  90                  95      
Lys Ala Glu Pro Pro Lys Ala Pro Glu Gln Glu Gln Ala Ala Pro Gly 
            100                 105                 110         
Pro Ala Ala Gly Gly Glu Ala Pro Lys Ala Ala Glu Ala Ala Ala Ala 
        115                 120                 125             
Pro Ala Glu Ser Ala Ala Pro Ala Ala Gly Glu Glu Pro Ser Lys Glu 
    130                 135                 140                 
Glu Gly Glu Pro Lys Lys Thr Glu Ala Pro Ala Ala Pro Ala Ala Gln 
145                 150                 155                 160 
Glu Thr Lys Ser Asp Gly Ala Pro Ala Ser Asp Ser Lys Pro Gly Ser 
                165                 170                 175     
Ser Glu Ala Ala Pro Ser Ser Lys Glu Thr Pro Ala Ala Thr Glu Ala 
            180                 185                 190         
Pro Ser Ser Thr Pro Lys Ala Gln Gly Pro Ala Ala Ser Ala Glu Glu 
        195                 200                 205             
Pro Lys Pro Val Glu Ala Pro Ala Ala Asn Ser Asp Gln Thr Val Thr 
    210                 215                 220                 
Val Lys Glu 
225         

<210> 116
<211> 2268
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2268
<223> /mol_type="unassigned DNA"
      /note="DES (Desmin)"
      /organism="Homo sapiens"

<400> 116
gtctcccctc gccgcatcca ctctccggcc ggccgcctgc ccgccgcctc ctccgtgcgc      60

ccgccagcct cgcccgcgcc gtcaccatga gccaggccta ctcgtccagc cagcgcgtgt     120

cctcctaccg ccgcaccttc ggcggggccc cgggcttccc actcggctcc ccgctgagtt     180

cgcccgtgtt cccgcgggcg ggtttcggct ctaagggctc ctccagctcg gtgacgtccc     240

gcgtgtacca ggtgtcgcgc acgtcgggcg gggccggggg cctggggtcg ctgcgggcca     300

gccggctggg gaccacccgc acgccctcct cctacggcgc aggcgagctg ctggacttct     360

cactggccga cgcggtgaac caggagtttc tgaccacgcg caccaacgag aaggtggagc     420

tgcaggagct caatgaccgc ttcgccaact acatcgagaa ggtgcgcttc ctggagcagc     480

agaacgcggc gctcgccgcc gaagtgaacc ggctcaaggg ccgcgagccg acgcgagtgg     540

ccgagctcta cgaggaggag ctgcgggagc tgcggcgcca ggtggaggtg ctcactaacc     600

agcgcgcgcg cgtcgacgtc gagcgcgaca acctgctcga cgacctgcag cggctcaagg     660

ccaagctgca ggaggagatt cagttgaagg aagaagcaga gaacaatttg gctgccttcc     720

gagcggacgt ggatgcagct actctagctc gcattgacct ggagcgcaga attgaatctc     780

tcaacgagga gatcgcgttc cttaagaaag tgcatgaaga ggagatccgt gagttgcagg     840

ctcagcttca ggaacagcag gtccaggtgg agatggacat gtctaagcca gacctcactg     900

ccgccctcag ggacatccgg gctcagtatg agaccatcgc ggctaagaac atttctgaag     960

ctgaggagtg gtacaagtcg aaggtgtcag acctgaccca ggcagccaac aagaacaacg    1020

acgccctgcg ccaggccaag caggagatga tggaataccg acaccagatc cagtcctaca    1080

cctgcgagat tgacgccctg aagggcacta acgattccct gatgaggcag atgcgggaat    1140

tggaggaccg atttgccagt gaggccagtg gctaccagga caacattgcg cgcctggagg    1200

aggaaatccg gcacctcaag gatgagatgg cccgccatct gcgcgagtac caggacctgc    1260

tcaacgtgaa gatggccctg gatgtggaga ttgccaccta ccggaagctg ctggagggag    1320

aggagagccg gatcaatctc cccatccaga cctactctgc cctcaacttc cgagaaacca    1380

gccctgagca aaggggttct gaggtccata ccaagaagac ggtgatgatc aagaccatcg    1440

agacacggga tggggaggtc gtcagtgagg ccacacagca gcagcatgaa gtgctctaaa    1500

gacagagacc ctctgccacc agagaccgtc ctcacccctg tcctcactgc tccctgaagc    1560

cagccttctt ccatcccagg acaccacacc cagcctcagt cctcccctca cagcctctga    1620

cccctcctca ctggccatcc ctcgtggtcc ccaacagcga catagcccat ccctgcctgg    1680

tcacagggca tgccccggcc acctctgcgg accccagctg tgagccttgg ctgttggcag    1740

tgagtgagcc tggctcttgt gctggatgga gcccaggcgg gagcggtggc cctgtccctc    1800

ccacctctgt gacctcaggc actagccttt ggctctggag acagccccag agcagggtgt    1860

tgggatactg cagggccagg actgagcccc gcagacctcc ccagccccta gcccaggaga    1920

gagaaagcca ggcaggtagc cagggggact agcccctgtg gagactgggg ggcttgaaat    1980

tgtccccgtg gtctcttact ttcctttccc cagcccaggg tggacttaga aagcaggggc    2040

tacaagaggg aatccccgaa ggtgctggag gtgggagcag gagattgaga aggagagaaa    2100

gtgggtgaga tgctggagaa gagaggagag gagagaggca gagagcggtc tcaggctggt    2160

gggaggggcg cccacctccc cacgccctcc cctcccctgc tgcaggggct ctggagagaa    2220

acaataaaga gattcacaca caagccaaaa aaaaaaaaaa aaaaaaaa                 2268


<210> 117
<211> 470
<212> PRT
<213> Homo sapiens

<220> 
<223> DES (Desmin)

<400> 117
Met Ser Gln Ala Tyr Ser Ser Ser Gln Arg Val Ser Ser Tyr Arg Arg 
1               5                   10                  15      
Thr Phe Gly Gly Ala Pro Gly Phe Pro Leu Gly Ser Pro Leu Ser Ser 
            20                  25                  30          
Pro Val Phe Pro Arg Ala Gly Phe Gly Ser Lys Gly Ser Ser Ser Ser 
        35                  40                  45              
Val Thr Ser Arg Val Tyr Gln Val Ser Arg Thr Ser Gly Gly Ala Gly 
    50                  55                  60                  
Gly Leu Gly Ser Leu Arg Ala Ser Arg Leu Gly Thr Thr Arg Thr Pro 
65                  70                  75                  80  
Ser Ser Tyr Gly Ala Gly Glu Leu Leu Asp Phe Ser Leu Ala Asp Ala 
                85                  90                  95      
Val Asn Gln Glu Phe Leu Thr Thr Arg Thr Asn Glu Lys Val Glu Leu 
            100                 105                 110         
Gln Glu Leu Asn Asp Arg Phe Ala Asn Tyr Ile Glu Lys Val Arg Phe 
        115                 120                 125             
Leu Glu Gln Gln Asn Ala Ala Leu Ala Ala Glu Val Asn Arg Leu Lys 
    130                 135                 140                 
Gly Arg Glu Pro Thr Arg Val Ala Glu Leu Tyr Glu Glu Glu Leu Arg 
145                 150                 155                 160 
Glu Leu Arg Arg Gln Val Glu Val Leu Thr Asn Gln Arg Ala Arg Val 
                165                 170                 175     
Asp Val Glu Arg Asp Asn Leu Leu Asp Asp Leu Gln Arg Leu Lys Ala 
            180                 185                 190         
Lys Leu Gln Glu Glu Ile Gln Leu Lys Glu Glu Ala Glu Asn Asn Leu 
        195                 200                 205             
Ala Ala Phe Arg Ala Asp Val Asp Ala Ala Thr Leu Ala Arg Ile Asp 
    210                 215                 220                 
Leu Glu Arg Arg Ile Glu Ser Leu Asn Glu Glu Ile Ala Phe Leu Lys 
225                 230                 235                 240 
Lys Val His Glu Glu Glu Ile Arg Glu Leu Gln Ala Gln Leu Gln Glu 
                245                 250                 255     
Gln Gln Val Gln Val Glu Met Asp Met Ser Lys Pro Asp Leu Thr Ala 
            260                 265                 270         
Ala Leu Arg Asp Ile Arg Ala Gln Tyr Glu Thr Ile Ala Ala Lys Asn 
        275                 280                 285             
Ile Ser Glu Ala Glu Glu Trp Tyr Lys Ser Lys Val Ser Asp Leu Thr 
    290                 295                 300                 
Gln Ala Ala Asn Lys Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu 
305                 310                 315                 320 
Met Met Glu Tyr Arg His Gln Ile Gln Ser Tyr Thr Cys Glu Ile Asp 
                325                 330                 335     
Ala Leu Lys Gly Thr Asn Asp Ser Leu Met Arg Gln Met Arg Glu Leu 
            340                 345                 350         
Glu Asp Arg Phe Ala Ser Glu Ala Ser Gly Tyr Gln Asp Asn Ile Ala 
        355                 360                 365             
Arg Leu Glu Glu Glu Ile Arg His Leu Lys Asp Glu Met Ala Arg His 
    370                 375                 380                 
Leu Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Val 
385                 390                 395                 400 
Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile 
                405                 410                 415     
Asn Leu Pro Ile Gln Thr Tyr Ser Ala Leu Asn Phe Arg Glu Thr Ser 
            420                 425                 430         
Pro Glu Gln Arg Gly Ser Glu Val His Thr Lys Lys Thr Val Met Ile 
        435                 440                 445             
Lys Thr Ile Glu Thr Arg Asp Gly Glu Val Val Ser Glu Ala Thr Gln 
    450                 455                 460                 
Gln Gln His Glu Val Leu 
465                 470 

<210> 118
<211> 7878
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..7878
<223> /mol_type="unassigned DNA"
      /note="ITGA2 (integrin, alpha 2)"
      /organism="Homo sapiens"

<400> 118
ttttccctgc tctcaccggg cgggggagag aagccctctg gacagcttct agagtgtgca       60

ggttctcgta tccctcggcc aagggtatcc tctgcaaacc tctgcaaacc cagcgcaact      120

acggtccccc ggtcagaccc aggatggggc cagaacggac aggggccgcg ccgctgccgc      180

tgctgctggt gttagcgctc agtcaaggca ttttaaattg ttgtttggcc tacaatgttg      240

gtctcccaga agcaaaaata ttttccggtc cttcaagtga acagtttggc tatgcagtgc      300

agcagtttat aaatccaaaa ggcaactggt tactggttgg ttcaccctgg agtggctttc      360

ctgagaaccg aatgggagat gtgtataaat gtcctgttga cctatccact gccacatgtg      420

aaaaactaaa tttgcaaact tcaacaagca ttccaaatgt tactgagatg aaaaccaaca      480

tgagcctcgg cttgatcctc accaggaaca tgggaactgg aggttttctc acatgtggtc      540

ctctgtgggc acagcaatgt gggaatcagt attacacaac gggtgtgtgt tctgacatca      600

gtcctgattt tcagctctca gccagcttct cacctgcaac tcagccctgc ccttccctca      660

tagatgttgt ggttgtgtgt gatgaatcaa atagtattta tccttgggat gcagtaaaga      720

attttttgga aaaatttgta caaggcctgg atataggccc cacaaagaca caggtggggt      780

taattcagta tgccaataat ccaagagttg tgtttaactt gaacacatat aaaaccaaag      840

aagaaatgat tgtagcaaca tcccagacat cccaatatgg tggggacctc acaaacacat      900

tcggagcaat tcaatatgca agaaaatatg cttattcagc agcttctggt gggcgacgaa      960

gtgctacgaa agtaatggta gttgtaactg acggtgaatc acatgatggt tcaatgttga     1020

aagctgtgat tgatcaatgc aaccatgaca atatactgag gtttggcata gcagttcttg     1080

ggtacttaaa cagaaacgcc cttgatacta aaaatttaat aaaagaaata aaagcaatcg     1140

ctagtattcc aacagaaaga tactttttca atgtgtctga tgaagcagct ctactagaaa     1200

aggctgggac attaggagaa caaattttca gcattgaagg tactgttcaa ggaggagaca     1260

actttcagat ggaaatgtca caagtgggat tcagtgcaga ttactcttct caaaatgata     1320

ttctgatgct gggtgcagtg ggagcttttg gctggagtgg gaccattgtc cagaagacat     1380

ctcatggcca tttgatcttt cctaaacaag cctttgacca aattctgcag gacagaaatc     1440

acagttcata tttaggttac tctgtggctg caatttctac tggagaaagc actcactttg     1500

ttgctggtgc tcctcgggca aattataccg gccagatagt gctatatagt gtgaatgaga     1560

atggcaatat cacggttatt caggctcacc gaggtgacca gattggctcc tattttggta     1620

gtgtgctgtg ttcagttgat gtggataaag acaccattac agacgtgctc ttggtaggtg     1680

caccaatgta catgagtgac ctaaagaaag aggaaggaag agtctacctg tttactatca     1740

aagagggcat tttgggtcag caccaatttc ttgaaggccc cgagggcatt gaaaacactc     1800

gatttggttc agcaattgca gctctttcag acatcaacat ggatggcttt aatgatgtga     1860

ttgttggttc accactagaa aatcagaatt ctggagctgt atacatttac aatggtcatc     1920

agggcactat ccgcacaaag tattcccaga aaatcttggg atccgatgga gcctttagga     1980

gccatctcca gtactttggg aggtccttgg atggctatgg agatttaaat ggggattcca     2040

tcaccgatgt gtctattggt gcctttggac aagtggttca actctggtca caaagtattg     2100

ctgatgtagc tatagaagct tcattcacac cagaaaaaat cactttggtc aacaagaatg     2160

ctcagataat tctcaaactc tgcttcagtg caaagttcag acctactaag caaaacaatc     2220

aagtggccat tgtatataac atcacacttg atgcagatgg attttcatcc agagtaacct     2280

ccagggggtt atttaaagaa aacaatgaaa ggtgcctgca gaagaatatg gtagtaaatc     2340

aagcacagag ttgccccgag cacatcattt atatacagga gccctctgat gttgtcaact     2400

ctttggattt gcgtgtggac atcagtctgg aaaaccctgg cactagccct gcccttgaag     2460

cctattctga gactgccaag gtcttcagta ttcctttcca caaagactgt ggtgaggacg     2520

gactttgcat ttctgatcta gtcctagatg tccgacaaat accagctgct caagaacaac     2580

cctttattgt cagcaaccaa aacaaaaggt taacattttc agtaacgctg aaaaataaaa     2640

gggaaagtgc atacaacact ggaattgttg ttgatttttc agaaaacttg ttttttgcat     2700

cattctccct gccggttgat gggacagaag taacatgcca ggtggctgca tctcagaagt     2760

ctgttgcctg cgatgtaggc taccctgctt taaagagaga acaacaggtg acttttacta     2820

ttaactttga cttcaatctt caaaaccttc agaatcaggc gtctctcagt ttccaagcct     2880

taagtgaaag ccaagaagaa aacaaggctg ataatttggt caacctcaaa attcctctcc     2940

tgtatgatgc tgaaattcac ttaacaagat ctaccaacat aaatttttat gaaatctctt     3000

cggatgggaa tgttccttca atcgtgcaca gttttgaaga tgttggtcca aaattcatct     3060

tctccctgaa ggtaacaaca ggaagtgttc cagtaagcat ggcaactgta atcatccaca     3120

tccctcagta taccaaagaa aagaacccac tgatgtacct aactggggtg caaacagaca     3180

aggctggtga catcagttgt aatgcagata tcaatccact gaaaatagga caaacatctt     3240

cttctgtatc tttcaaaagt gaaaatttca ggcacaccaa agaattgaac tgcagaactg     3300

cttcctgtag taatgttacc tgctggttga aagacgttca catgaaagga gaatactttg     3360

ttaatgtgac taccagaatt tggaacggga ctttcgcatc atcaacgttc cagacagtac     3420

agctaacggc agctgcagaa atcaacacct ataaccctga gatatatgtg attgaagata     3480

acactgttac gattcccctg atgataatga aacctgatga gaaagccgaa gtaccaacag     3540

gagttataat aggaagtata attgctggaa tccttttgct gttagctctg gttgcaattt     3600

tatggaagct cggcttcttc aaaagaaaat atgaaaagat gaccaaaaat ccagatgaga     3660

ttgatgagac cacagagctc agtagctgaa ccagcagacc tacctgcagt gggaaccggc     3720

agcatcccag ccagggtttg ctgtttgcgt gaatggattt ctttttaaat cccatatttt     3780

ttttatcatg tcgtaggtaa actaacctgg tattttaaga gaaaactgca ggtcagtttg     3840

gaatgaagaa attgtggggg gtgggggagg tgcggggggc aggtagggaa ataataggga     3900

aaatacctat tttatatgat gggggaaaaa aagtaatctt taaactggct ggcccagagt     3960

ttacattcta atttgcattg tgtcagaaac atgaaatgct tccaagcatg acaactttta     4020

aagaaaaata tgatactctc agattttaag ggggaaaact gttctcttta aaatatttgt     4080

ctttaaacag caactacaga agtggaagtg cttgatatgt aagtacttcc acttgtgtat     4140

attttaatga atattgatgt taacaagagg ggaaaacaaa acacaggttt tttcaattta     4200

tgctgctcat ccaaagttgc cacagatgat acttccaagt gataatttta tttataaact     4260

aggtaaaatt tgttgttggt tccttttaga ccacggctgc cccttccaca ccccatcttg     4320

ctctaatgat caaaacatgc ttgaataact gagcttagag tatacctcct atatgtccat     4380

ttaagttagg agagggggcg atatagagaa taaggcacaa aattttgttt aaaactcaga     4440

atataacatg taaaatccca tctgctagaa gcccatcctg tgccagagga aggaaaagga     4500

ggaaatttcc tttctctttt aggaggcaca acagttctct tctaggattt gtttggctga     4560

ctggcagtaa cctagtgaat ttctgaaaga tgagtaattt ctttggcaac cttcctcctc     4620

ccttactgaa ccactctccc acctcctggt ggtaccatta ttatagaagc cctctacagc     4680

ctgactttct ctccagcggt ccaaagttat cccctccttt acccctcatc caaagttccc     4740

actccttcag gacagctgct gtgcattaga tattaggggg gaaagtcatc tgtttaattt     4800

acacacttgc atgaattact gtatataaac tccttaactt cagggagcta ttttcattta     4860

gtgctaaaca agtaagaaaa ataagctcga gtgaatttct aaatgttgga atgttatggg     4920

atgtaaacaa tgtaaagtaa gacatctcag gatttcacca gaagttacag atgaggcact     4980

ggaagccacc aaattagcag gtgcaccttc tgtggctgtc ttgtttctga agtacttaaa     5040

cttccacaag agtgaatttg acctaggcaa gtttgttcaa aaggtagatc ctgagatgat     5100

ttggtcagat tgggataagg cccagcaatc tgcattttaa caagcacccc agtcactagg     5160

atgcagatgg accacacttt gagaaacacc acccatttct actttttgca ccttattttc     5220

tctgttcctg agcccccaca ttctctagga gaaacttaga ggaaaagggc acagacacta     5280

catatctaaa gctttggaca agtccttgac ctctataaac ttcagagtcc tcattataaa     5340

atgggaagac tgagctggag ttcagcagtg atgcttttag ttttaaaagt ctatgatctg     5400

gacttcctat aatacaaata cacaatcctc caagaatttg acttggaaaa aaatgtcaaa     5460

ggaaaacagg ttatctgccc atgtgcatat ggacaacctt gactaccctg gcctggcccg     5520

tggtggcagt ccagggctat ctgtactgtt tacagaatta ctttgtagtt gacaacacaa     5580

aacaaacaaa aaaggcataa aatgccagcg gtttatagaa aaaacagcat ggtattctcc     5640

agttaggtat gccagagtcc aattctttta acagctgtga gaatttgctg cttcattcca     5700

acaaaatttt atttaaaaaa aaaaaaaaaa gactggagaa actagtcatt agcttgataa     5760

agaatattta acagctagtg gtgctggtgt gtacctgaag ctccagctac ttgagagact     5820

gagacaggaa gatcgcttga gcccaggagt tcaagtccag cctaagcaac atagcaagac     5880

cctgtctcaa aaaaatgact atttaaaaag acaatgtggc caggcacggt ggctcacacc     5940

tgtaatccca acactttggg aggctgaggc cggtggatca cgaggtcagg agtttgagac     6000

tagcctggcc aacatggtga aaccccatct ctaataatat aaaaattagc tgggcgtagt     6060

agcaggtgcc tgtaatccca gttactcggg aagctgaggc aggagaatca cttgaacccg     6120

ggaggcagag gtttcagtga gccgagatcg cgccactgca ctccagcctg ggtgacaggg     6180

caagactctg tctcaaacaa acaaacaaaa aaaaagttag tactgtatat gtaaatacta     6240

gcttttcaat gtgctataca aacaattata gcacatcctt ccttttactc tgtctcacct     6300

cctttaggtg agtacttcct taaataagtg ctaaacatac atatacggaa cttgaaagct     6360

ttggttagcc ttgccttagg taatcagcct agtttacact gtttccaggg agtagttgaa     6420

ttactataaa ccattagcca cttgtctctg caccatttat cacaccagga cagggtctct     6480

caacctgggc gctactgtca tttggggcca ggtgattctt ccttgcaggg gctgtcctgt     6540

accttgtagg acagcagccc tgtcctagaa ggtatgttta gcagcattcc tggcctctag     6600

ctacccgatg ccagagcatg ctccccccgc agtcatgaca atcaaaaaat gtctccagac     6660

attgtcaaat gcctcctggg gggcagtatt tctcaagcac ttttaagcaa aggtaagtat     6720

tcatacaaga aatttagggg gaaaaaacat tgtttaaata aaagctatgt gttcctattc     6780

aacaatattt ttgctttaaa agtaagtaga gggcataaaa gatgtcatat tcaaatttcc     6840

atttcataaa tggtgtacag acaaggtcta tagaatgtgg taaaaacttg actgcaacac     6900

aaggcttata aaatagtaag atagtaaaat agcttatgaa gaaactacag agatttaaaa     6960

ttgtgcatga ctcatttcag cagcaaaata agaactccta actgaacaga aatttttcta     7020

cctagcaatg ttattcttgt aaaatagtta cctattaaaa ctgtgaagag taaaactaaa     7080

gccaatttat tatagtcaca caagtgatta tactaaaaat tattataaag gttataattt     7140

tataatgtat ttacctgtcc tgatatatag ctataaccca atatatgaaa atctcaaaaa     7200

ttaagacatc atcatacaga aggcaggatt ccttaaactg agatccctga tccatcttta     7260

atatttcaat ttgcacacat aaaacaatgc ccttttgtgt acattcaggc atacccattt     7320

taatcaattt gaaaggttaa tttaaacctc tagaggtgaa tgagaaacat gggggaaaag     7380

tatgaaatag gtgaaaatct taactatttc tttgaactct aaagactgaa actgtagcca     7440

ttatgtaaat aaagtttcat atgtacctgt ttattttggc agattaagtc aaaatatgaa     7500

tgtatatatt gcataactat gttagaattg tatatatttt aaagaaattg tcttggatat     7560

tttcctttat acataataga taagtctttt ttcaaatgtg gtgtttgatg tttttgatta     7620

aatgtgtttt gcctctttcc acaaaaactg taaaaataaa tgcatgtttg tacaaaaagt     7680

tgcagaattc atttgattta tgagaaacaa aaattaaatt gtagtcaaca gttagtagtt     7740

tttctcatat ccaagtataa caaacagaaa agtttcatta ttgtaaccca cttttttcat     7800

accacattat tgaatattgt tacaattgtt ttgaaaataa agccattttc tttgggcttt     7860

tataagttaa aaaaaaaa                                                   7878


<210> 119
<211> 1181
<212> PRT
<213> Homo sapiens

<220> 
<223> ITGA2 (integrin, alpha 2)

<400> 119
Met Gly Pro Glu Arg Thr Gly Ala Ala Pro Leu Pro Leu Leu Leu Val 
1               5                   10                  15      
Leu Ala Leu Ser Gln Gly Ile Leu Asn Cys Cys Leu Ala Tyr Asn Val 
            20                  25                  30          
Gly Leu Pro Glu Ala Lys Ile Phe Ser Gly Pro Ser Ser Glu Gln Phe 
        35                  40                  45              
Gly Tyr Ala Val Gln Gln Phe Ile Asn Pro Lys Gly Asn Trp Leu Leu 
    50                  55                  60                  
Val Gly Ser Pro Trp Ser Gly Phe Pro Glu Asn Arg Met Gly Asp Val 
65                  70                  75                  80  
Tyr Lys Cys Pro Val Asp Leu Ser Thr Ala Thr Cys Glu Lys Leu Asn 
                85                  90                  95      
Leu Gln Thr Ser Thr Ser Ile Pro Asn Val Thr Glu Met Lys Thr Asn 
            100                 105                 110         
Met Ser Leu Gly Leu Ile Leu Thr Arg Asn Met Gly Thr Gly Gly Phe 
        115                 120                 125             
Leu Thr Cys Gly Pro Leu Trp Ala Gln Gln Cys Gly Asn Gln Tyr Tyr 
    130                 135                 140                 
Thr Thr Gly Val Cys Ser Asp Ile Ser Pro Asp Phe Gln Leu Ser Ala 
145                 150                 155                 160 
Ser Phe Ser Pro Ala Thr Gln Pro Cys Pro Ser Leu Ile Asp Val Val 
                165                 170                 175     
Val Val Cys Asp Glu Ser Asn Ser Ile Tyr Pro Trp Asp Ala Val Lys 
            180                 185                 190         
Asn Phe Leu Glu Lys Phe Val Gln Gly Leu Asp Ile Gly Pro Thr Lys 
        195                 200                 205             
Thr Gln Val Gly Leu Ile Gln Tyr Ala Asn Asn Pro Arg Val Val Phe 
    210                 215                 220                 
Asn Leu Asn Thr Tyr Lys Thr Lys Glu Glu Met Ile Val Ala Thr Ser 
225                 230                 235                 240 
Gln Thr Ser Gln Tyr Gly Gly Asp Leu Thr Asn Thr Phe Gly Ala Ile 
                245                 250                 255     
Gln Tyr Ala Arg Lys Tyr Ala Tyr Ser Ala Ala Ser Gly Gly Arg Arg 
            260                 265                 270         
Ser Ala Thr Lys Val Met Val Val Val Thr Asp Gly Glu Ser His Asp 
        275                 280                 285             
Gly Ser Met Leu Lys Ala Val Ile Asp Gln Cys Asn His Asp Asn Ile 
    290                 295                 300                 
Leu Arg Phe Gly Ile Ala Val Leu Gly Tyr Leu Asn Arg Asn Ala Leu 
305                 310                 315                 320 
Asp Thr Lys Asn Leu Ile Lys Glu Ile Lys Ala Ile Ala Ser Ile Pro 
                325                 330                 335     
Thr Glu Arg Tyr Phe Phe Asn Val Ser Asp Glu Ala Ala Leu Leu Glu 
            340                 345                 350         
Lys Ala Gly Thr Leu Gly Glu Gln Ile Phe Ser Ile Glu Gly Thr Val 
        355                 360                 365             
Gln Gly Gly Asp Asn Phe Gln Met Glu Met Ser Gln Val Gly Phe Ser 
    370                 375                 380                 
Ala Asp Tyr Ser Ser Gln Asn Asp Ile Leu Met Leu Gly Ala Val Gly 
385                 390                 395                 400 
Ala Phe Gly Trp Ser Gly Thr Ile Val Gln Lys Thr Ser His Gly His 
                405                 410                 415     
Leu Ile Phe Pro Lys Gln Ala Phe Asp Gln Ile Leu Gln Asp Arg Asn 
            420                 425                 430         
His Ser Ser Tyr Leu Gly Tyr Ser Val Ala Ala Ile Ser Thr Gly Glu 
        435                 440                 445             
Ser Thr His Phe Val Ala Gly Ala Pro Arg Ala Asn Tyr Thr Gly Gln 
    450                 455                 460                 
Ile Val Leu Tyr Ser Val Asn Glu Asn Gly Asn Ile Thr Val Ile Gln 
465                 470                 475                 480 
Ala His Arg Gly Asp Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Cys 
                485                 490                 495     
Ser Val Asp Val Asp Lys Asp Thr Ile Thr Asp Val Leu Leu Val Gly 
            500                 505                 510         
Ala Pro Met Tyr Met Ser Asp Leu Lys Lys Glu Glu Gly Arg Val Tyr 
        515                 520                 525             
Leu Phe Thr Ile Lys Glu Gly Ile Leu Gly Gln His Gln Phe Leu Glu 
    530                 535                 540                 
Gly Pro Glu Gly Ile Glu Asn Thr Arg Phe Gly Ser Ala Ile Ala Ala 
545                 550                 555                 560 
Leu Ser Asp Ile Asn Met Asp Gly Phe Asn Asp Val Ile Val Gly Ser 
                565                 570                 575     
Pro Leu Glu Asn Gln Asn Ser Gly Ala Val Tyr Ile Tyr Asn Gly His 
            580                 585                 590         
Gln Gly Thr Ile Arg Thr Lys Tyr Ser Gln Lys Ile Leu Gly Ser Asp 
        595                 600                 605             
Gly Ala Phe Arg Ser His Leu Gln Tyr Phe Gly Arg Ser Leu Asp Gly 
    610                 615                 620                 
Tyr Gly Asp Leu Asn Gly Asp Ser Ile Thr Asp Val Ser Ile Gly Ala 
625                 630                 635                 640 
Phe Gly Gln Val Val Gln Leu Trp Ser Gln Ser Ile Ala Asp Val Ala 
                645                 650                 655     
Ile Glu Ala Ser Phe Thr Pro Glu Lys Ile Thr Leu Val Asn Lys Asn 
            660                 665                 670         
Ala Gln Ile Ile Leu Lys Leu Cys Phe Ser Ala Lys Phe Arg Pro Thr 
        675                 680                 685             
Lys Gln Asn Asn Gln Val Ala Ile Val Tyr Asn Ile Thr Leu Asp Ala 
    690                 695                 700                 
Asp Gly Phe Ser Ser Arg Val Thr Ser Arg Gly Leu Phe Lys Glu Asn 
705                 710                 715                 720 
Asn Glu Arg Cys Leu Gln Lys Asn Met Val Val Asn Gln Ala Gln Ser 
                725                 730                 735     
Cys Pro Glu His Ile Ile Tyr Ile Gln Glu Pro Ser Asp Val Val Asn 
            740                 745                 750         
Ser Leu Asp Leu Arg Val Asp Ile Ser Leu Glu Asn Pro Gly Thr Ser 
        755                 760                 765             
Pro Ala Leu Glu Ala Tyr Ser Glu Thr Ala Lys Val Phe Ser Ile Pro 
    770                 775                 780                 
Phe His Lys Asp Cys Gly Glu Asp Gly Leu Cys Ile Ser Asp Leu Val 
785                 790                 795                 800 
Leu Asp Val Arg Gln Ile Pro Ala Ala Gln Glu Gln Pro Phe Ile Val 
                805                 810                 815     
Ser Asn Gln Asn Lys Arg Leu Thr Phe Ser Val Thr Leu Lys Asn Lys 
            820                 825                 830         
Arg Glu Ser Ala Tyr Asn Thr Gly Ile Val Val Asp Phe Ser Glu Asn 
        835                 840                 845             
Leu Phe Phe Ala Ser Phe Ser Leu Pro Val Asp Gly Thr Glu Val Thr 
    850                 855                 860                 
Cys Gln Val Ala Ala Ser Gln Lys Ser Val Ala Cys Asp Val Gly Tyr 
865                 870                 875                 880 
Pro Ala Leu Lys Arg Glu Gln Gln Val Thr Phe Thr Ile Asn Phe Asp 
                885                 890                 895     
Phe Asn Leu Gln Asn Leu Gln Asn Gln Ala Ser Leu Ser Phe Gln Ala 
            900                 905                 910         
Leu Ser Glu Ser Gln Glu Glu Asn Lys Ala Asp Asn Leu Val Asn Leu 
        915                 920                 925             
Lys Ile Pro Leu Leu Tyr Asp Ala Glu Ile His Leu Thr Arg Ser Thr 
    930                 935                 940                 
Asn Ile Asn Phe Tyr Glu Ile Ser Ser Asp Gly Asn Val Pro Ser Ile 
945                 950                 955                 960 
Val His Ser Phe Glu Asp Val Gly Pro Lys Phe Ile Phe Ser Leu Lys 
                965                 970                 975     
Val Thr Thr Gly Ser Val Pro Val Ser Met Ala Thr Val Ile Ile His 
            980                 985                 990         
Ile Pro Gln Tyr Thr Lys Glu Lys Asn Pro Leu Met Tyr Leu Thr Gly 
        995                 1000                1005            
Val Gln Thr Asp Lys Ala Gly Asp Ile Ser Cys Asn Ala Asp Ile Asn 
    1010                1015                1020                
Pro Leu Lys Ile Gly Gln Thr Ser Ser Ser Val Ser Phe Lys Ser Glu 
1025                1030                1035                1040
Asn Phe Arg His Thr Lys Glu Leu Asn Cys Arg Thr Ala Ser Cys Ser 
                1045                1050                1055    
Asn Val Thr Cys Trp Leu Lys Asp Val His Met Lys Gly Glu Tyr Phe 
            1060                1065                1070        
Val Asn Val Thr Thr Arg Ile Trp Asn Gly Thr Phe Ala Ser Ser Thr 
        1075                1080                1085            
Phe Gln Thr Val Gln Leu Thr Ala Ala Ala Glu Ile Asn Thr Tyr Asn 
    1090                1095                1100                
Pro Glu Ile Tyr Val Ile Glu Asp Asn Thr Val Thr Ile Pro Leu Met 
1105                1110                1115                1120
Ile Met Lys Pro Asp Glu Lys Ala Glu Val Pro Thr Gly Val Ile Ile 
                1125                1130                1135    
Gly Ser Ile Ile Ala Gly Ile Leu Leu Leu Leu Ala Leu Val Ala Ile 
            1140                1145                1150        
Leu Trp Lys Leu Gly Phe Phe Lys Arg Lys Tyr Glu Lys Met Thr Lys 
        1155                1160                1165            
Asn Pro Asp Glu Ile Asp Glu Thr Thr Glu Leu Ser Ser 
    1170                1175                1180    

<210> 120
<211> 4107
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..4107
<223> /mol_type="unassigned DNA"
      /note="CTSS (Cathepsin S)"
      /organism="Homo sapiens"

<400> 120
gacaagggct cttcttgatg gcttactgta tccactttgt ccccaagacc atagggaaat       60

gactagaggt gactgtacta gctagatttt aaatgaaact gaaatgaaag ttcacttcct      120

cattttgagt acctcatgtg acaagttcca atttcttttc aagtcaattg aactgaaatc      180

tccttgttgc tttgaaatct tagaagagag cccactaatt caaggactct tactgtggga      240

gcaactgctg gttctatcac aatgaaacgg ctggtttgtg tgctcttggt gtgctcctct      300

gcagtggcac agttgcataa agatcctacc ctggatcacc actggcatct ctggaagaaa      360

acctatggca aacaatacaa ggaaaagaat gaagaagcag tacgacgtct catctgggaa      420

aagaatctaa agtttgtgat gcttcacaac ctggagcatt caatgggaat gcactcatac      480

gatctgggca tgaaccacct gggagacatg accagtgaag aagtgatgtc tttgatgagt      540

tccctgagag ttcccagcca gtggcagaga aatatcacat ataagtcaaa ccctaatcgg      600

atattgcctg attctgtgga ctggagagag aaagggtgtg ttactgaagt gaaatatcaa      660

ggttcttgtg gtgcttgctg ggctttcagt gctgtggggg ccctggaagc acagctgaag      720

ctgaaaacag gaaagctggt gtctctcagt gcccagaacc tggtggattg ctcaactgaa      780

aaatatggaa acaaaggctg caatggtggc ttcatgacaa cggctttcca gtacatcatt      840

gataacaagg gcatcgactc agacgcttcc tatccctaca aagccatgga tcagaaatgt      900

caatatgact caaaatatcg tgctgccaca tgttcaaagt acactgaact tccttatggc      960

agagaagatg tcctgaaaga agctgtggcc aataaaggcc cagtgtctgt tggtgtagat     1020

gcgcgtcatc cttctttctt cctctacaga agtggtgtct actatgaacc atcctgtact     1080

cagaatgtga atcatggtgt acttgtggtt ggctatggtg atcttaatgg gaaagaatac     1140

tggcttgtga aaaacagctg gggccacaac tttggtgaag aaggatatat tcggatggca     1200

agaaataaag gaaatcattg tgggattgct agctttccct cttacccaga aatctagagg     1260

atctctcctt tttataacaa atcaagaaat atgaagcact ttctcttaac ttaatttttc     1320

ctgctgtatc cagaagaaat aattgtgtca tgattaatgt gtatttactg tactaattag     1380

aaaatatagt ttgaggccgg gcacggtggc tcacgcctgt aatcccagta cttgggaggc     1440

caaggcaggc atatcaactt gaggccagga gttaaagagc agcctggcta acatggtgaa     1500

accccatctc tactaaaaat acaaaaaatt agccgagcac ggtggtgcat gcctgtaatc     1560

ccagctactt gggaggctga ggcacgagat tccttgaacc caagaggttg aggctatgtt     1620

gagctgagat cacaccactg tactccagcc tggatgacag agtggagact ctgtttcaaa     1680

aaaacagaaa agaaaatata gtttgattct tcattttttt aaatttgcaa atctcaggat     1740

aaagtttgct aagtaaatta gtaatgtact atagatataa ctgtacaaaa attgttcaac     1800

ctaaaacaat ctgtaattgc ttattgtttt attgtatact ctttgtcttt ttaagacccc     1860

taatagcctt ttgtaacttg atggcttaaa aatacttaat aaatctgcca tttcaaattt     1920

ctatcattgc cacataccat tcttattcct aggcaactat taataatcta tcctgagaat     1980

attaattgtg gtattctggt gatggggttt agcaactttg atggaagaaa atattaggct     2040

ataaatgtcc taaggactca gattgtatct ttgtacagaa gaggattcaa aacgccacgt     2100

gtagtggctc atgcctgtaa tcccaacact ttgggaggct gaagtaggag gatcgtcttg     2160

agcccaggag ttcaagacca gcctggacaa catagtgaga ccttgtctcc acaaaaataa     2220

aaaagaaact atccaggagt ggtggtgtgt gcctgtggtc cctgctatgc agatgtctaa     2280

gacaggagga tcacaagagc ccaggaggtt gagaatgcag tgagcttgta attgcaccac     2340

tgcactccag cctgggtgac agagcaagac cctgtcttaa aaaaagagga ttcaacacat     2400

atttttatat tatgttaaag taaagaaatg cataaaagac aagcactttg gaagaattat     2460

tttaatgatc aacaatttaa tgtattagtc caaattattt ttacgtagtc atcaacaatt     2520

tgaccagggc ctttatttgg caaataactg agccaaccag aataaaataa ccaatactcc     2580

actgctcata tttttatcta attcagatgg atcttcctta caactgctct agattagtag     2640

atgcatctaa gcaggcagca ggaactttaa attttttaag ttcatgtcta tgacatgaac     2700

aatgtgtggg ataatgtcat taatatatcc taaattaacc taaacgtatt tcactaactc     2760

tggctccttc tccataaagc acattttaag gaacaagaat tgctaaatat aaaaacataa     2820

ataataccat aatacatggc tatcatcaaa agtgtataga atattatagt ttaaaagtat     2880

ttagttgatt acttttcagt tttgttttgt tttttgagac ggagtctcac tctgttgccc     2940

aggctggagt gcagtggcac catctcagtt cactgcaact tctgcctccc gagttcaagc     3000

gattctcctg cctcagcctc ccgagtagct ggaattatag gcgtgcacca ccacgcccag     3060

ctaatttttg tatttttagt aaagacaggg ttttgccaca ttagccaggc tggtctcaaa     3120

ctcctgacct caggtgatcc acccacccca gcctcccaaa gtgctaagat tacaggcgtg     3180

agccactgag cccagcctac ttttcagttt ttaacataat ttttgtttta tccacaactt     3240

ttcaagtatt gaaagtagaa taaaaacatg ggttcttagt ctttagctat ctgttaaagc     3300

ctatgaatgc cttcttaaaa tcatgttttt aaatgcataa aatatatagg attacaaagg     3360

aatctaatta tatcgaaata cagttattaa aatgttaaaa gataagtttg ttatatatta     3420

atatgcatgc ttctttataa atgcattaaa taagagttaa tagctatcct aaatttgaaa     3480

tagtgataag cataatgaaa atagatgcaa aaaactaatg tgatatgaaa atatctgggt     3540

ttttcttttg atgatgaagt attgctaata ttaccgtggt ttatgaacta tgttcagaat     3600

tgaagaaaat cctaactttc agttagaggt tagtgacggg gttcaggaca ccctacacaa     3660

aatacagcac tttgacatat tgaatatttt aagctgaagg catttgagga aattgcagaa     3720

gcaggaaggt gactctgacc ttctgcctgc tgttctcccc agaagcagcc ataaaacctg     3780

ggaaggattt tctgaccttc ccctgaagta gatcataaga ctgtcatgta agaggtgctc     3840

tcctggcacc cagagaaaag gagcatcctt acctccaaaa gcacagggac acaaagagga     3900

atctaaacaa acaggcctct cagtttcccc cagtttatta catttagctt gttcacactt     3960

tgccctatga catttctaca tcactggctg ctcttcatca aacctactat aaaaaacatt     4020

caagttcaac tgtttctttg ggcctttatt tccttatgga gcccctcgtg tcgtgtaaaa     4080

cttatattaa ataaatgtgc atgcttt                                         4107


<210> 121
<211> 3957
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3957
<223> /mol_type="unassigned DNA"
      /note="CTSS (Cathepsin S)"
      /organism="Homo sapiens"

<400> 121
gacaagggct cttcttgatg gcttactgta tccactttgt ccccaagacc atagggaaat       60

gactagaggt gactgtacta gctagatttt aaatgaaact gaaatgaaag ttcacttcct      120

cattttgagt acctcatgtg acaagttcca atttcttttc aagtcaattg aactgaaatc      180

tccttgttgc tttgaaatct tagaagagag cccactaatt caaggactct tactgtggga      240

gcaactgctg gttctatcac aatgaaacgg ctggtttgtg tgctcttggt gtgctcctct      300

gcagtggcac agttgcataa agatcctacc ctggatcacc actggcatct ctggaagaaa      360

acctatggca aacaatacaa ggaaaagaat gaagaagcag tacgacgtct catctgggaa      420

aagaatctaa agtttgtgat gcttcacaac ctggagcatt caatgggaat gcactcatac      480

gatctgggca tgaaccacct gggagacatg ggttcttgtg gtgcttgctg ggctttcagt      540

gctgtggggg ccctggaagc acagctgaag ctgaaaacag gaaagctggt gtctctcagt      600

gcccagaacc tggtggattg ctcaactgaa aaatatggaa acaaaggctg caatggtggc      660

ttcatgacaa cggctttcca gtacatcatt gataacaagg gcatcgactc agacgcttcc      720

tatccctaca aagccatgga tcagaaatgt caatatgact caaaatatcg tgctgccaca      780

tgttcaaagt acactgaact tccttatggc agagaagatg tcctgaaaga agctgtggcc      840

aataaaggcc cagtgtctgt tggtgtagat gcgcgtcatc cttctttctt cctctacaga      900

agtggtgtct actatgaacc atcctgtact cagaatgtga atcatggtgt acttgtggtt      960

ggctatggtg atcttaatgg gaaagaatac tggcttgtga aaaacagctg gggccacaac     1020

tttggtgaag aaggatatat tcggatggca agaaataaag gaaatcattg tgggattgct     1080

agctttccct cttacccaga aatctagagg atctctcctt tttataacaa atcaagaaat     1140

atgaagcact ttctcttaac ttaatttttc ctgctgtatc cagaagaaat aattgtgtca     1200

tgattaatgt gtatttactg tactaattag aaaatatagt ttgaggccgg gcacggtggc     1260

tcacgcctgt aatcccagta cttgggaggc caaggcaggc atatcaactt gaggccagga     1320

gttaaagagc agcctggcta acatggtgaa accccatctc tactaaaaat acaaaaaatt     1380

agccgagcac ggtggtgcat gcctgtaatc ccagctactt gggaggctga ggcacgagat     1440

tccttgaacc caagaggttg aggctatgtt gagctgagat cacaccactg tactccagcc     1500

tggatgacag agtggagact ctgtttcaaa aaaacagaaa agaaaatata gtttgattct     1560

tcattttttt aaatttgcaa atctcaggat aaagtttgct aagtaaatta gtaatgtact     1620

atagatataa ctgtacaaaa attgttcaac ctaaaacaat ctgtaattgc ttattgtttt     1680

attgtatact ctttgtcttt ttaagacccc taatagcctt ttgtaacttg atggcttaaa     1740

aatacttaat aaatctgcca tttcaaattt ctatcattgc cacataccat tcttattcct     1800

aggcaactat taataatcta tcctgagaat attaattgtg gtattctggt gatggggttt     1860

agcaactttg atggaagaaa atattaggct ataaatgtcc taaggactca gattgtatct     1920

ttgtacagaa gaggattcaa aacgccacgt gtagtggctc atgcctgtaa tcccaacact     1980

ttgggaggct gaagtaggag gatcgtcttg agcccaggag ttcaagacca gcctggacaa     2040

catagtgaga ccttgtctcc acaaaaataa aaaagaaact atccaggagt ggtggtgtgt     2100

gcctgtggtc cctgctatgc agatgtctaa gacaggagga tcacaagagc ccaggaggtt     2160

gagaatgcag tgagcttgta attgcaccac tgcactccag cctgggtgac agagcaagac     2220

cctgtcttaa aaaaagagga ttcaacacat atttttatat tatgttaaag taaagaaatg     2280

cataaaagac aagcactttg gaagaattat tttaatgatc aacaatttaa tgtattagtc     2340

caaattattt ttacgtagtc atcaacaatt tgaccagggc ctttatttgg caaataactg     2400

agccaaccag aataaaataa ccaatactcc actgctcata tttttatcta attcagatgg     2460

atcttcctta caactgctct agattagtag atgcatctaa gcaggcagca ggaactttaa     2520

attttttaag ttcatgtcta tgacatgaac aatgtgtggg ataatgtcat taatatatcc     2580

taaattaacc taaacgtatt tcactaactc tggctccttc tccataaagc acattttaag     2640

gaacaagaat tgctaaatat aaaaacataa ataataccat aatacatggc tatcatcaaa     2700

agtgtataga atattatagt ttaaaagtat ttagttgatt acttttcagt tttgttttgt     2760

tttttgagac ggagtctcac tctgttgccc aggctggagt gcagtggcac catctcagtt     2820

cactgcaact tctgcctccc gagttcaagc gattctcctg cctcagcctc ccgagtagct     2880

ggaattatag gcgtgcacca ccacgcccag ctaatttttg tatttttagt aaagacaggg     2940

ttttgccaca ttagccaggc tggtctcaaa ctcctgacct caggtgatcc acccacccca     3000

gcctcccaaa gtgctaagat tacaggcgtg agccactgag cccagcctac ttttcagttt     3060

ttaacataat ttttgtttta tccacaactt ttcaagtatt gaaagtagaa taaaaacatg     3120

ggttcttagt ctttagctat ctgttaaagc ctatgaatgc cttcttaaaa tcatgttttt     3180

aaatgcataa aatatatagg attacaaagg aatctaatta tatcgaaata cagttattaa     3240

aatgttaaaa gataagtttg ttatatatta atatgcatgc ttctttataa atgcattaaa     3300

taagagttaa tagctatcct aaatttgaaa tagtgataag cataatgaaa atagatgcaa     3360

aaaactaatg tgatatgaaa atatctgggt ttttcttttg atgatgaagt attgctaata     3420

ttaccgtggt ttatgaacta tgttcagaat tgaagaaaat cctaactttc agttagaggt     3480

tagtgacggg gttcaggaca ccctacacaa aatacagcac tttgacatat tgaatatttt     3540

aagctgaagg catttgagga aattgcagaa gcaggaaggt gactctgacc ttctgcctgc     3600

tgttctcccc agaagcagcc ataaaacctg ggaaggattt tctgaccttc ccctgaagta     3660

gatcataaga ctgtcatgta agaggtgctc tcctggcacc cagagaaaag gagcatcctt     3720

acctccaaaa gcacagggac acaaagagga atctaaacaa acaggcctct cagtttcccc     3780

cagtttatta catttagctt gttcacactt tgccctatga catttctaca tcactggctg     3840

ctcttcatca aacctactat aaaaaacatt caagttcaac tgtttctttg ggcctttatt     3900

tccttatgga gcccctcgtg tcgtgtaaaa cttatattaa ataaatgtgc atgcttt        3957


<210> 122
<211> 331
<212> PRT
<213> Homo sapiens

<220> 
<223> CTSS (Cathepsin S)

<400> 122
Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala 
1               5                   10                  15      
Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys 
            20                  25                  30          
Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
        35                  40                  45              
Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
    50                  55                  60                  
Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
65                  70                  75                  80  
Gly Asp Met Thr Ser Glu Glu Val Met Ser Leu Met Ser Ser Leu Arg 
                85                  90                  95      
Val Pro Ser Gln Trp Gln Arg Asn Ile Thr Tyr Lys Ser Asn Pro Asn 
            100                 105                 110         
Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr 
        115                 120                 125             
Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala 
    130                 135                 140                 
Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val 
145                 150                 155                 160 
Ser Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly 
                165                 170                 175     
Asn Lys Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile 
            180                 185                 190         
Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala 
        195                 200                 205             
Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys 
    210                 215                 220                 
Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu 
225                 230                 235                 240 
Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His 
                245                 250                 255     
Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys 
            260                 265                 270         
Thr Gln Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu 
        275                 280                 285             
Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe 
    290                 295                 300                 
Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys 
305                 310                 315                 320 
Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
                325                 330     

<210> 123
<211> 281
<212> PRT
<213> Homo sapiens

<220> 
<223> CTSS (Cathepsin S)

<400> 123
Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala 
1               5                   10                  15      
Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys 
            20                  25                  30          
Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg 
        35                  40                  45              
Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu 
    50                  55                  60                  
Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu 
65                  70                  75                  80  
Gly Asp Met Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala Val Gly 
                85                  90                  95      
Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val Ser Leu 
            100                 105                 110         
Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly Asn Lys 
        115                 120                 125             
Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile Ile Asp 
    130                 135                 140                 
Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala Met Asp 
145                 150                 155                 160 
Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys Ser Lys 
                165                 170                 175     
Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu Ala Val 
            180                 185                 190         
Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His Pro Ser 
        195                 200                 205             
Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys Thr Gln 
    210                 215                 220                 
Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu Asn Gly 
225                 230                 235                 240 
Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe Gly Glu 
                245                 250                 255     
Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys Gly Ile 
            260                 265                 270         
Ala Ser Phe Pro Ser Tyr Pro Glu Ile 
        275                 280     

<210> 124
<211> 1477
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1477
<223> /mol_type="unassigned DNA"
      /note="PTPRC (protein tyrosine phosphatase, receptor type, C)"
      /organism="Homo sapiens"

<400> 124
agaacaactt ttttgacttc ctgcaaagag gacccttaca gtatttttgg agaagttagt      60

aaaaccgaat ctgacatcat cacctagcag ttcatgcagc tagcaagtgg tttgttctta     120

gggtaacaga ggaggaaatt gttcctcgtc tgataagaca acagtggaga aaggacgcat     180

gctgtttctt agggacacgg ctgacttcca gatatgacca tgtatttgtg gcttaaactc     240

ttggcatttg gctttgcctt tctggacaca gaagtatttg tgacagggca aagcccaaca     300

ccttccccca ctggccatct gcaagctgag gagcaaggaa gccaatccaa gtcaccaaac     360

ctcaaaagta gggaagctga cagttcagcc ttcagttggt ggccaaaggc ccgagagccc     420

ctcacaaacc actggagtaa gtccaagagt ccaaaagctg aggaacttgg agtctgatgt     480

tcaagagcag gaagcagcca gcacgagaga aagatgaaga ccagaagact cagcaagctc     540

acttctccta ccttcttgtg cctgcttttt ctagccgtgc tggcagttgc ttggatgatg     600

cccactcata ttgggtgggg gtgggggggt tggggagggt ctgcctcccc cagtccactg     660

actcaaatgt taatctccct tggcaatacg ctcacaggca cacccaggaa caatactttg     720

catccttcaa tccaatcaag ttgacactca atattaacca tcaaatacta ttataaggag     780

aatgttgcat gattttcctt ctagtctgtt tgtaattcac atctaatgaa agagtgagag     840

tggacgataa agggaacttg ttgaaacatt tctctcaaag caaaagggat cattggaagc     900

aggcagacac cagaattggt ttaacctaaa aataacaaat taataattat caagtctata     960

atgatgacag tgacttaatg tgaatagaaa gaattctaaa ctctctcctt ccttcctccc    1020

tcccttcttt cctactttct ttccactccc tttctcccac ccccttttct tttcctttct    1080

tttctcccac cctctctccc tccctttctt ttattcaatg catagtagtt gaaaaaatct    1140

aaagttagac ctgattttac actgaagact agaggtagtt actatcctat tactgtactt    1200

agttggctat gctggcatgt cattatgggt aaaagtttga tggatttatt tgtgagttat    1260

ttggttatga aaatctagag attgaagttt ttcattagaa aataacacac ataacaagtc    1320

tatgatcatt ttgcatttct gtaatcacag aatagttctg caatatttca tgtatattgg    1380

aattgaagtt caattgaatt ttatctgtat ttagtaaaaa ttaactttag ctttgatact    1440

aatgaataaa gctgggtttt ttatttaaaa aaaaaaa                             1477


<210> 125
<211> 5429
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..5429
<223> /mol_type="unassigned DNA"
      /note="PTPRC (protein tyrosine phosphatase, receptor type, C)"
      /organism="Homo sapiens"

<400> 125
agaacaactt ttttgacttc ctgcaaagag gacccttaca gtatttttgg agaagttagt       60

aaaaccgaat ctgacatcat cacctagcag ttcatgcagc tagcaagtgg tttgttctta      120

gggtaacaga ggaggaaatt gttcctcgtc tgataagaca acagtggaga aaggacgcat      180

gctgtttctt agggacacgg ctgacttcca gatatgacca tgtatttgtg gcttaaactc      240

ttggcatttg gctttgcctt tctggacaca gaagtatttg tgacagggca aagcccaaca      300

ccttccccca ctggattgac tacagcaaag atgcccagtg ttccactttc aagtgacccc      360

ttacctactc acaccactgc attctcaccc gcaagcacct ttgaaagaga aaatgacttc      420

tcagagacca caacttctct tagtccagac aatacttcca cccaagtatc cccggactct      480

ttggataatg ctagtgcttt taataccaca ggtgtttcat cagtacagac gcctcacctt      540

cccacgcacg cagactcgca gacgccctct gctggaactg acacgcagac attcagcggc      600

tccgccgcca atgcaaaact caaccctacc ccaggcagca atgctatctc agatgtccca      660

ggagagagga gtacagccag cacctttcct acagacccag tttccccatt gacaaccacc      720

ctcagccttg cacaccacag ctctgctgcc ttacctgcac gcacctccaa caccaccatc      780

acagcgaaca cctcagatgc ctaccttaat gcctctgaaa caaccactct gagcccttct      840

ggaagcgctg tcatttcaac cacaacaata gctactactc catctaagcc aacatgtgat      900

gaaaaatatg caaacatcac tgtggattac ttatataaca aggaaactaa attatttaca      960

gcaaagctaa atgttaatga gaatgtggaa tgtggaaaca atacttgcac aaacaatgag     1020

gtgcataacc ttacagaatg taaaaatgcg tctgtttcca tatctcataa ttcatgtact     1080

gctcctgata agacattaat attagatgtg ccaccagggg ttgaaaagtt tcagttacat     1140

gattgtacac aagttgaaaa agcagatact actatttgtt taaaatggaa aaatattgaa     1200

acctttactt gtgatacaca gaatattacc tacagatttc agtgtggtaa tatgatattt     1260

gataataaag aaattaaatt agaaaacctt gaacccgaac atgagtataa gtgtgactca     1320

gaaatactct ataataacca caagtttact aacgcaagta aaattattaa aacagatttt     1380

gggagtccag gagagcctca gattattttt tgtagaagtg aagctgcaca tcaaggagta     1440

attacctgga atccccctca aagatcattt cataatttta ccctctgtta tataaaagag     1500

acagaaaaag attgcctcaa tctggataaa aacctgatca aatatgattt gcaaaattta     1560

aaaccttata cgaaatatgt tttatcatta catgcctaca tcattgcaaa agtgcaacgt     1620

aatggaagtg ctgcaatgtg tcatttcaca actaaaagtg ctcctccaag ccaggtctgg     1680

aacatgactg tctccatgac atcagataat agtatgcatg tcaagtgtag gcctcccagg     1740

gaccgtaatg gcccccatga acgttaccat ttggaagttg aagctggaaa tactctggtt     1800

agaaatgagt cgcataagaa ttgcgatttc cgtgtaaaag atcttcaata ttcaacagac     1860

tacactttta aggcctattt tcacaatgga gactatcctg gagaaccctt tattttacat     1920

cattcaacat cttataattc taaggcactg atagcatttc tggcatttct gattattgtg     1980

acatcaatag ccctgcttgt tgttctctac aaaatctatg atctacataa gaaaagatcc     2040

tgcaatttag atgaacagca ggagcttgtt gaaagggatg atgaaaaaca actgatgaat     2100

gtggagccaa tccatgcaga tattttgttg gaaacttata agaggaagat tgctgatgaa     2160

ggaagacttt ttctggctga atttcagagc atcccgcggg tgttcagcaa gtttcctata     2220

aaggaagctc gaaagccctt taaccagaat aaaaaccgtt atgttgacat tcttccttat     2280

gattataacc gtgttgaact ctctgagata aacggagatg cagggtcaaa ctacataaat     2340

gccagctata ttgatggttt caaagaaccc aggaaataca ttgctgcaca aggtcccagg     2400

gatgaaactg ttgatgattt ctggaggatg atttgggaac agaaagccac agttattgtc     2460

atggtcactc gatgtgaaga aggaaacagg aacaagtgtg cagaatactg gccgtcaatg     2520

gaagagggca ctcgggcttt tggagatgtt gttgtaaaga tcaaccagca caaaagatgt     2580

ccagattaca tcattcagaa attgaacatt gtaaataaaa aagaaaaagc aactggaaga     2640

gaggtgactc acattcagtt caccagctgg ccagaccacg gggtgcctga ggatcctcac     2700

ttgctcctca aactgagaag gagagtgaat gccttcagca atttcttcag tggtcccatt     2760

gtggtgcact gcagtgctgg tgttgggcgc acaggaacct atatcggaat tgatgccatg     2820

ctagaaggcc tggaagccga gaacaaagtg gatgtttatg gttatgttgt caagctaagg     2880

cgacagagat gcctgatggt tcaagtagag gcccagtaca tcttgatcca tcaggctttg     2940

gtggaataca atcagtttgg agaaacagaa gtgaatttgt ctgaattaca tccatatcta     3000

cataacatga agaaaaggga tccacccagt gagccgtctc cactagaggc tgaattccag     3060

agacttcctt catataggag ctggaggaca cagcacattg gaaatcaaga agaaaataaa     3120

agtaaaaaca ggaattctaa tgtcatccca tatgactata acagagtgcc acttaaacat     3180

gagctggaaa tgagtaaaga gagtgagcat gattcagatg aatcctctga tgatgacagt     3240

gattcagagg aaccaagcaa atacatcaat gcatctttta taatgagcta ctggaaacct     3300

gaagtgatga ttgctgctca gggaccactg aaggagacca ttggtgactt ttggcagatg     3360

atcttccaaa gaaaagtcaa agttattgtt atgctgacag aactgaaaca tggagaccag     3420

gaaatctgtg ctcagtactg gggagaagga aagcaaacat atggagatat tgaagttgac     3480

ctgaaagaca cagacaaatc ttcaacttat acccttcgtg tctttgaact gagacattcc     3540

aagaggaaag actctcgaac tgtgtaccag taccaatata caaactggag tgtggagcag     3600

cttcctgcag aacccaagga attaatctct atgattcagg tcgtcaaaca aaaacttccc     3660

cagaagaatt cctctgaagg gaacaagcat cacaagagta cacctctact cattcactgc     3720

agggatggat ctcagcaaac gggaatattt tgtgctttgt taaatctctt agaaagtgcg     3780

gaaacagaag aggtagtgga tatttttcaa gtggtaaaag ctctacgcaa agctaggcca     3840

ggcatggttt ccacattcga gcaatatcaa ttcctatatg acgtcattgc cagcacctac     3900

cctgctcaga atggacaagt aaagaaaaac aaccatcaag aagataaaat tgaatttgat     3960

aatgaagtgg acaaagtaaa gcaggatgct aattgtgtta atccacttgg tgccccagaa     4020

aagctccctg aagcaaagga acaggctgaa ggttctgaac ccacgagtgg cactgagggg     4080

ccagaacatt ctgtcaatgg tcctgcaagt ccagctttaa atcaaggttc ataggaaaag     4140

acataaatga ggaaactcca aacctcctgt tagctgttat ttctattttt gtagaagtag     4200

gaagtgaaaa taggtataca gtggattaat taaatgcagc gaaccaatat ttgtagaagg     4260

gttatatttt actactgtgg aaaaatattt aagatagttt tgccagaaca gtttgtacag     4320

acgtatgctt attttaaaat tttatctctt attcagtaaa aaacaacttc tttgtaatcg     4380

ttatgtgtgt atatgtatgt gtgtatgggt gtgtgtttgt gtgagagaca gagaaagaga     4440

gagaattctt tcaagtgaat ctaaaagctt ttgcttttcc tttgttttta tgaagaaaaa     4500

atacatttta tattagaagt gttaacttag cttgaaggat ctgtttttaa aaatcataaa     4560

ctgtgtgcag actcaataaa atcatgtaca tttctgaaat gacctcaaga tgtcctcctt     4620

gttctactca tatatatcta tcttatatag tttactattt tacttctaga gatagtacat     4680

aaaggtggta tgtgtgtgta tgctactaca aaaaagttgt taactaaatt aacattggga     4740

aatcttatat tccatatatt agcatttagt ccaatgtctt tttaagctta tttaattaaa     4800

aaatttccag tgagcttatc atgctgtctt tacatggggt tttcaatttt gcatgctcga     4860

ttattccctg tacaatattt aaaatttatt gcttgatact tttgacaaca aattaggttt     4920

tgtacaattg aacttaaata aatgtcatta aaataaataa atgcaatatg tattaatatt     4980

cattgtataa aaatagaaga atacaaacat atttgttaaa tatttacata tgaaatttaa     5040

tatagctatt tttatggaat ttttcattga tatgaaaaat atgatattgc atatgcatag     5100

ttcccatgtt aaatcccatt cataactttc attaaagcat ttactttgaa tttctccaat     5160

gcttagaatg tttttaccag gaatggatgt cgctaatcat aataaaattc aaccattatt     5220

tttttcttgt ttataataca ttgtgttata tgttcaaata tgaaatgtgt atgcacctat     5280

tgaaatatgt ttaatgcatt tattaacatt tgcaggacac ttttacaggc cccaattatc     5340

caatagtcta ataattgttt aagatctaga aaaaaaaaat caagaatagt ggtatttttc     5400

atgaagtaat aaaaactcgt tttggtgaa                                       5429


<210> 126
<211> 4946
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..4946
<223> /mol_type="unassigned DNA"
      /note="PTPRC (protein tyrosine phosphatase, receptor type, C)"
      /organism="Homo sapiens"

<400> 126
agaacaactt ttttgacttc ctgcaaagag gacccttaca gtatttttgg agaagttagt       60

aaaaccgaat ctgacatcat cacctagcag ttcatgcagc tagcaagtgg tttgttctta      120

gggtaacaga ggaggaaatt gttcctcgtc tgataagaca acagtggaga aaggacgcat      180

gctgtttctt agggacacgg ctgacttcca gatatgacca tgtatttgtg gcttaaactc      240

ttggcatttg gctttgcctt tctggacaca gaagtatttg tgacagggca aagcccaaca      300

ccttccccca ctgatgccta ccttaatgcc tctgaaacaa ccactctgag cccttctgga      360

agcgctgtca tttcaaccac aacaatagct actactccat ctaagccaac atgtgatgaa      420

aaatatgcaa acatcactgt ggattactta tataacaagg aaactaaatt atttacagca      480

aagctaaatg ttaatgagaa tgtggaatgt ggaaacaata cttgcacaaa caatgaggtg      540

cataacctta cagaatgtaa aaatgcgtct gtttccatat ctcataattc atgtactgct      600

cctgataaga cattaatatt agatgtgcca ccaggggttg aaaagtttca gttacatgat      660

tgtacacaag ttgaaaaagc agatactact atttgtttaa aatggaaaaa tattgaaacc      720

tttacttgtg atacacagaa tattacctac agatttcagt gtggtaatat gatatttgat      780

aataaagaaa ttaaattaga aaaccttgaa cccgaacatg agtataagtg tgactcagaa      840

atactctata ataaccacaa gtttactaac gcaagtaaaa ttattaaaac agattttggg      900

agtccaggag agcctcagat tattttttgt agaagtgaag ctgcacatca aggagtaatt      960

acctggaatc cccctcaaag atcatttcat aattttaccc tctgttatat aaaagagaca     1020

gaaaaagatt gcctcaatct ggataaaaac ctgatcaaat atgatttgca aaatttaaaa     1080

ccttatacga aatatgtttt atcattacat gcctacatca ttgcaaaagt gcaacgtaat     1140

ggaagtgctg caatgtgtca tttcacaact aaaagtgctc ctccaagcca ggtctggaac     1200

atgactgtct ccatgacatc agataatagt atgcatgtca agtgtaggcc tcccagggac     1260

cgtaatggcc cccatgaacg ttaccatttg gaagttgaag ctggaaatac tctggttaga     1320

aatgagtcgc ataagaattg cgatttccgt gtaaaagatc ttcaatattc aacagactac     1380

acttttaagg cctattttca caatggagac tatcctggag aaccctttat tttacatcat     1440

tcaacatctt ataattctaa ggcactgata gcatttctgg catttctgat tattgtgaca     1500

tcaatagccc tgcttgttgt tctctacaaa atctatgatc tacataagaa aagatcctgc     1560

aatttagatg aacagcagga gcttgttgaa agggatgatg aaaaacaact gatgaatgtg     1620

gagccaatcc atgcagatat tttgttggaa acttataaga ggaagattgc tgatgaagga     1680

agactttttc tggctgaatt tcagagcatc ccgcgggtgt tcagcaagtt tcctataaag     1740

gaagctcgaa agccctttaa ccagaataaa aaccgttatg ttgacattct tccttatgat     1800

tataaccgtg ttgaactctc tgagataaac ggagatgcag ggtcaaacta cataaatgcc     1860

agctatattg atggtttcaa agaacccagg aaatacattg ctgcacaagg tcccagggat     1920

gaaactgttg atgatttctg gaggatgatt tgggaacaga aagccacagt tattgtcatg     1980

gtcactcgat gtgaagaagg aaacaggaac aagtgtgcag aatactggcc gtcaatggaa     2040

gagggcactc gggcttttgg agatgttgtt gtaaagatca accagcacaa aagatgtcca     2100

gattacatca ttcagaaatt gaacattgta aataaaaaag aaaaagcaac tggaagagag     2160

gtgactcaca ttcagttcac cagctggcca gaccacgggg tgcctgagga tcctcacttg     2220

ctcctcaaac tgagaaggag agtgaatgcc ttcagcaatt tcttcagtgg tcccattgtg     2280

gtgcactgca gtgctggtgt tgggcgcaca ggaacctata tcggaattga tgccatgcta     2340

gaaggcctgg aagccgagaa caaagtggat gtttatggtt atgttgtcaa gctaaggcga     2400

cagagatgcc tgatggttca agtagaggcc cagtacatct tgatccatca ggctttggtg     2460

gaatacaatc agtttggaga aacagaagtg aatttgtctg aattacatcc atatctacat     2520

aacatgaaga aaagggatcc acccagtgag ccgtctccac tagaggctga attccagaga     2580

cttccttcat ataggagctg gaggacacag cacattggaa atcaagaaga aaataaaagt     2640

aaaaacagga attctaatgt catcccatat gactataaca gagtgccact taaacatgag     2700

ctggaaatga gtaaagagag tgagcatgat tcagatgaat cctctgatga tgacagtgat     2760

tcagaggaac caagcaaata catcaatgca tcttttataa tgagctactg gaaacctgaa     2820

gtgatgattg ctgctcaggg accactgaag gagaccattg gtgacttttg gcagatgatc     2880

ttccaaagaa aagtcaaagt tattgttatg ctgacagaac tgaaacatgg agaccaggaa     2940

atctgtgctc agtactgggg agaaggaaag caaacatatg gagatattga agttgacctg     3000

aaagacacag acaaatcttc aacttatacc cttcgtgtct ttgaactgag acattccaag     3060

aggaaagact ctcgaactgt gtaccagtac caatatacaa actggagtgt ggagcagctt     3120

cctgcagaac ccaaggaatt aatctctatg attcaggtcg tcaaacaaaa acttccccag     3180

aagaattcct ctgaagggaa caagcatcac aagagtacac ctctactcat tcactgcagg     3240

gatggatctc agcaaacggg aatattttgt gctttgttaa atctcttaga aagtgcggaa     3300

acagaagagg tagtggatat ttttcaagtg gtaaaagctc tacgcaaagc taggccaggc     3360

atggtttcca cattcgagca atatcaattc ctatatgacg tcattgccag cacctaccct     3420

gctcagaatg gacaagtaaa gaaaaacaac catcaagaag ataaaattga atttgataat     3480

gaagtggaca aagtaaagca ggatgctaat tgtgttaatc cacttggtgc cccagaaaag     3540

ctccctgaag caaaggaaca ggctgaaggt tctgaaccca cgagtggcac tgaggggcca     3600

gaacattctg tcaatggtcc tgcaagtcca gctttaaatc aaggttcata ggaaaagaca     3660

taaatgagga aactccaaac ctcctgttag ctgttatttc tatttttgta gaagtaggaa     3720

gtgaaaatag gtatacagtg gattaattaa atgcagcgaa ccaatatttg tagaagggtt     3780

atattttact actgtggaaa aatatttaag atagttttgc cagaacagtt tgtacagacg     3840

tatgcttatt ttaaaatttt atctcttatt cagtaaaaaa caacttcttt gtaatcgtta     3900

tgtgtgtata tgtatgtgtg tatgggtgtg tgtttgtgtg agagacagag aaagagagag     3960

aattctttca agtgaatcta aaagcttttg cttttccttt gtttttatga agaaaaaata     4020

cattttatat tagaagtgtt aacttagctt gaaggatctg tttttaaaaa tcataaactg     4080

tgtgcagact caataaaatc atgtacattt ctgaaatgac ctcaagatgt cctccttgtt     4140

ctactcatat atatctatct tatatagttt actattttac ttctagagat agtacataaa     4200

ggtggtatgt gtgtgtatgc tactacaaaa aagttgttaa ctaaattaac attgggaaat     4260

cttatattcc atatattagc atttagtcca atgtcttttt aagcttattt aattaaaaaa     4320

tttccagtga gcttatcatg ctgtctttac atggggtttt caattttgca tgctcgatta     4380

ttccctgtac aatatttaaa atttattgct tgatactttt gacaacaaat taggttttgt     4440

acaattgaac ttaaataaat gtcattaaaa taaataaatg caatatgtat taatattcat     4500

tgtataaaaa tagaagaata caaacatatt tgttaaatat ttacatatga aatttaatat     4560

agctattttt atggaatttt tcattgatat gaaaaatatg atattgcata tgcatagttc     4620

ccatgttaaa tcccattcat aactttcatt aaagcattta ctttgaattt ctccaatgct     4680

tagaatgttt ttaccaggaa tggatgtcgc taatcataat aaaattcaac cattattttt     4740

ttcttgttta taatacattg tgttatatgt tcaaatatga aatgtgtatg cacctattga     4800

aatatgttta atgcatttat taacatttgc aggacacttt tacaggcccc aattatccaa     4860

tagtctaata attgtttaag atctagaaaa aaaaaatcaa gaatagtggt atttttcatg     4920

aagtaataaa aactcgtttt ggtgaa                                          4946


<210> 127
<211> 1156
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1156
<223> /mol_type="unassigned DNA"
      /note="PTPRC (protein tyrosine phosphatase, receptor type, C)"
      /organism="Homo sapiens"

<400> 127
agaacaactt ttttgacttc ctgcaaagag gacccttaca gtatttttgg agaagttagt      60

aaaaccgaat ctgacatcat cacctagcag ttcatgcagc tagcaagtgg tttgttctta     120

gggtaacaga ggaggaaatt gttcctcgtc tgataagaca acagtggaga aaggacgcat     180

gctgtttctt agggacacgg ctgacttcca gatatgacca tgtatttgtg gcttaaactc     240

ttggcatttg gctttgcctt tctggacaca gaagtatttg tgacagggca aagcccaaca     300

ccttccccca ctggtaagaa ttaatattta tatttttact aattttattt tcttgttgca     360

aagtttatat atttaactac aattttctat tattaacact gaaattattt ttaaggataa     420

attttataat catgagtgat tcttgacatt cacttgttct taaactttct gcttatacgt     480

tatagagttt aataactacc taaacatgtt attaaatttg tatatatatt ttgtgtataa     540

atagtaactt ttcccaaact tgacagtaaa tcacacaaca ggtttctact ctcttttaat     600

attttaagac tataaaaaaa tgcatttaaa ttagataaca aaattttata gtctgaaagc     660

aggttaacag ctgtctatgt atgttataga tatgtagata acagatttgc atatgtctat     720

atttctttaa gagtatgttg cttttttcaa tggtatgcaa aacctttgag actattgaga     780

tatttttaaa taataatttt caaattctac tgaacacttc aatagtcctt ataaatgtct     840

taatcatgag ataaatttaa aacacagaga tgctgcaaat aaattcatac atagtacata     900

caaaataaga gaaaaaatta aattgcagat ggttaaatat cacatcactt aactgatgtt     960

actgaaaatg tattttcctg cataatcata tggttgacag tatgcattaa gaaggtaagt    1020

aaaacaatga agacaatttt gatttaatat ggtaatgcac aattccaact aacgtacatt    1080

caacagatca tgaaattggg ttattaaaat gaatattttt gtcattaaat aaaaattccg    1140

tccaaaaaaa aaaaaa                                                    1156


<210> 128
<211> 87
<212> PRT
<213> Homo sapiens

<220> 
<223> PTPRC (protein tyrosine phosphatase, receptor type, C)

<400> 128
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          
Thr Gly His Leu Gln Ala Glu Glu Gln Gly Ser Gln Ser Lys Ser Pro 
        35                  40                  45              
Asn Leu Lys Ser Arg Glu Ala Asp Ser Ser Ala Phe Ser Trp Trp Pro 
    50                  55                  60                  
Lys Ala Arg Glu Pro Leu Thr Asn His Trp Ser Lys Ser Lys Ser Pro 
65                  70                  75                  80  
Lys Ala Glu Glu Leu Gly Val 
                85          

<210> 129
<211> 1306
<212> PRT
<213> Homo sapiens

<220> 
<223> PTPRC (protein tyrosine phosphatase, receptor type, C)

<400> 129
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          
Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              
Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  
Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  
Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      
Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         
Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             
Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 
Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 
Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 
                165                 170                 175     
Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         
Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
        195                 200                 205             
Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
    210                 215                 220                 
Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
225                 230                 235                 240 
Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     
Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
            260                 265                 270         
Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
        275                 280                 285             
Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
    290                 295                 300                 
Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
305                 310                 315                 320 
Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
                325                 330                 335     
Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
            340                 345                 350         
Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
        355                 360                 365             
Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
    370                 375                 380                 
Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
385                 390                 395                 400 
Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
                405                 410                 415     
Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
            420                 425                 430         
Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
        435                 440                 445             
Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
    450                 455                 460                 
Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
465                 470                 475                 480 
Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
                485                 490                 495     
Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
            500                 505                 510         
Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
        515                 520                 525             
Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
    530                 535                 540                 
Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
545                 550                 555                 560 
Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
                565                 570                 575     
Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
            580                 585                 590         
Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
        595                 600                 605             
Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
    610                 615                 620                 
Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
625                 630                 635                 640 
Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
                645                 650                 655     
Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
            660                 665                 670         
Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
        675                 680                 685             
Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
    690                 695                 700                 
Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
705                 710                 715                 720 
Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
                725                 730                 735     
Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
            740                 745                 750         
Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
        755                 760                 765             
Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
    770                 775                 780                 
Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
785                 790                 795                 800 
Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
                805                 810                 815     
Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
            820                 825                 830         
Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
        835                 840                 845             
Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
    850                 855                 860                 
Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
865                 870                 875                 880 
Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
                885                 890                 895     
Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
            900                 905                 910         
Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
        915                 920                 925             
Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
    930                 935                 940                 
Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
945                 950                 955                 960 
His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
                965                 970                 975     
Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
            980                 985                 990         
Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp 
        995                 1000                1005            
Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met 
    1010                1015                1020                
Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys 
1025                1030                1035                1040
Glu Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys 
                1045                1050                1055    
Val Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys 
            1060                1065                1070        
Ala Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val 
        1075                1080                1085            
Asp Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe 
    1090                1095                1100                
Glu Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr 
1105                1110                1115                1120
Gln Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu 
                1125                1130                1135    
Leu Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn 
            1140                1145                1150        
Ser Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His 
        1155                1160                1165            
Cys Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn 
    1170                1175                1180                
Leu Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val 
1185                1190                1195                1200
Val Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu 
                1205                1210                1215    
Gln Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln 
            1220                1225                1230        
Asn Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe 
        1235                1240                1245            
Asp Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro 
    1250                1255                1260                
Leu Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly 
1265                1270                1275                1280
Ser Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly 
                1285                1290                1295    
Pro Ala Ser Pro Ala Leu Asn Gln Gly Ser 
            1300                1305    

<210> 130
<211> 1145
<212> PRT
<213> Homo sapiens

<220> 
<223> PTPRC (protein tyrosine phosphatase, receptor type, C)

<400> 130
Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      
Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          
Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 
        35                  40                  45              
Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 
    50                  55                  60                  
Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 
65                  70                  75                  80  
Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 
                85                  90                  95      
Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 
            100                 105                 110         
Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 
        115                 120                 125             
Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 
    130                 135                 140                 
Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 
145                 150                 155                 160 
Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 
                165                 170                 175     
Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 
            180                 185                 190         
Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 
        195                 200                 205             
Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 
    210                 215                 220                 
Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 
225                 230                 235                 240 
Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 
                245                 250                 255     
Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 
            260                 265                 270         
Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 
        275                 280                 285             
Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 
    290                 295                 300                 
Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 
305                 310                 315                 320 
Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 
                325                 330                 335     
Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 
            340                 345                 350         
Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 
        355                 360                 365             
Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 
    370                 375                 380                 
Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 
385                 390                 395                 400 
Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 
                405                 410                 415     
Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
            420                 425                 430         
Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
        435                 440                 445             
Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
    450                 455                 460                 
Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
465                 470                 475                 480 
Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
                485                 490                 495     
Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
            500                 505                 510         
Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
        515                 520                 525             
Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
    530                 535                 540                 
Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
545                 550                 555                 560 
Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
                565                 570                 575     
Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
            580                 585                 590         
Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
        595                 600                 605             
Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
    610                 615                 620                 
His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
625                 630                 635                 640 
Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
                645                 650                 655     
Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
            660                 665                 670         
Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
        675                 680                 685             
Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
    690                 695                 700                 
Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
705                 710                 715                 720 
Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
                725                 730                 735     
Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
            740                 745                 750         
Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
        755                 760                 765             
His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
    770                 775                 780                 
Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
785                 790                 795                 800 
Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
                805                 810                 815     
Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
            820                 825                 830         
Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
        835                 840                 845             
Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
    850                 855                 860                 
Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
865                 870                 875                 880 
Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
                885                 890                 895     
Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
            900                 905                 910         
Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
        915                 920                 925             
Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
    930                 935                 940                 
Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
945                 950                 955                 960 
Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
                965                 970                 975     
Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
            980                 985                 990         
Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys 
        995                 1000                1005            
Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu 
    1010                1015                1020                
Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val 
1025                1030                1035                1040
Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln 
                1045                1050                1055    
Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn 
            1060                1065                1070        
Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp 
        1075                1080                1085            
Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu 
    1090                1095                1100                
Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser 
1105                1110                1115                1120
Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro 
                1125                1130                1135    
Ala Ser Pro Ala Leu Asn Gln Gly Ser 
            1140                1145

<210> 131
<211> 3740
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3740
<223> /mol_type="unassigned DNA"
      /note="ANPEP (alanyl (membrane) aminopeptidase)"
      /organism="Homo sapiens"

<400> 131
gggacggcgg cggcgcagct cggaacccgc cagggtccag ggtccaggtt ccagcgcccg       60

gcggcccagg caccccccga gcccagctcc acacaccgtt cctggatctc ctctccccag      120

gcggagcgtg cccctgccca gtccagtgac cttcgcctgt tggagccctg gttaattttt      180

gcccagtctg cctgttgtgg ggctcctccc ctttggggat ataagcccgg cctggggctg      240

ctccgttctc tgcctggcct gaggctccct gagccgcctc cccaccatca ccatggccaa      300

gggcttctat atttccaagt ccctgggcat cctggggatc ctcctgggcg tggcagccgt      360

gtgcacaatc atcgcactgt cagtggtgta ctcccaggag aagaacaaga acgccaacag      420

ctcccccgtg gcctccacca ccccgtccgc ctcagccacc accaaccccg cctcggccac      480

caccttggac caaagtaaag cgtggaatcg ttaccgcctc cccaacacgc tgaaacccga      540

ttcctaccgg gtgacgctga gaccgtacct cacccccaat gacaggggcc tgtacgtttt      600

taagggctcc agcaccgtcc gtttcacctg caaggaggcc actgacgtca tcatcatcca      660

cagcaagaag ctcaactaca ccctcagcca ggggcacagg gtggtcctgc gtggtgtggg      720

aggctcccag ccccccgaca ttgacaagac tgagctggtg gagcccaccg agtacctggt      780

ggtgcacctc aagggctccc tggtgaagga cagccagtat gagatggaca gcgagttcga      840

gggggagttg gcagatgacc tggcgggctt ctaccgcagc gagtacatgg agggcaatgt      900

cagaaaggtg gtggccacta cacagatgca ggctgcagat gcccggaagt ccttcccatg      960

cttcgatgag ccggccatga aggccgagtt caacatcacg cttatccacc ccaaggacct     1020

gacagccctg tccaacatgc ttcccaaagg tcccagcacc ccacttccag aagaccccaa     1080

ctggaatgtc actgagttcc acaccacgcc caagatgtcc acgtacttgc tggccttcat     1140

tgtcagtgag ttcgactacg tggagaagca ggcatccaat ggtgtcttga tccggatctg     1200

ggcccggccc agtgccattg cggcgggcca cggcgattat gccctgaacg tgacgggccc     1260

catccttaac ttctttgctg gtcattatga cacaccctac ccactcccaa aatcagacca     1320

gattggcctg ccagacttca acgccggcgc catggagaac tggggactgg tgacctaccg     1380

ggagaactcc ctgctgttcg accccctgtc ctcctccagc agcaacaagg agcgggtggt     1440

cactgtgatt gctcatgagc tggcccacca gtggttcggg aacctggtga ccatagagtg     1500

gtggaatgac ctgtggctga acgagggctt cgcctcctac gtggagtacc tgggtgctga     1560

ctatgcggag cccacctgga acttgaaaga cctcatggtg ctgaatgatg tgtaccgcgt     1620

gatggcagtg gatgcactgg cctcctccca cccgctgtcc acacccgcct cggagatcaa     1680

cacgccggcc cagatcagtg agctgtttga cgccatctcc tacagcaagg gcgcctcagt     1740

cctcaggatg ctctccagct tcctgtccga ggacgtattc aagcagggcc tggcgtccta     1800

cctccacacc tttgcctacc agaacaccat ctacctgaac ctgtgggacc acctgcagga     1860

ggctgtgaac aaccggtcca tccaactccc caccaccgtg cgggacatca tgaaccgctg     1920

gaccctgcag atgggcttcc cggtcatcac ggtggatacc agcacgggga ccctttccca     1980

ggagcacttc ctccttgacc ccgattccaa tgttacccgc ccctcagaat tcaactacgt     2040

gtggattgtg cccatcacat ccatcagaga tggcagacag cagcaggact actggctgat     2100

agatgtaaga gcccagaacg atctcttcag cacatcaggc aatgagtggg tcctgctgaa     2160

cctcaatgtg acgggctatt accgggtgaa ctacgacgaa gagaactgga ggaagattca     2220

gactcagctg cagagagacc actcggccat ccctgtcatc aatcgggcac agatcattaa     2280

tgacgccttc aacctggcca gtgcccataa ggtccctgtc actctggcgc tgaacaacac     2340

cctcttcctg attgaagaga gacagtacat gccctgggag gccgccctga gcagcctgag     2400

ctacttcaag ctcatgtttg accgctccga ggtctatggc cccatgaaga actacctgaa     2460

gaagcaggtc acacccctct tcattcactt cagaaataat accaacaact ggagggagat     2520

cccagaaaac ctgatggacc agtacagcga ggttaatgcc atcagcaccg cctgctccaa     2580

cggagttcca gagtgtgagg agatggtctc tggccttttc aagcagtgga tggagaaccc     2640

caataataac ccgatccacc ccaacctgcg gtccaccgtc tactgcaacg ctatcgccca     2700

gggcggggag gaggagtggg acttcgcctg ggagcagttc cgaaatgcca cactggtcaa     2760

tgaggctgac aagctccggg cagccctggc ctgcagcaaa gagttgtgga tcctgaacag     2820

gtacctgagc tacaccctga acccggactt aatccggaag caggacgcca cctctaccat     2880

catcagcatt accaacaacg tcattgggca aggtctggtc tgggactttg tccagagcaa     2940

ctggaagaag ctttttaacg attatggtgg tggctcgttc tccttctcca acctcatcca     3000

ggcagtgaca cgacgattct ccaccgagta tgagctgcag cagctggagc agttcaagaa     3060

ggacaacgag gaaacaggct tcggctcagg cacccgggcc ctggagcaag ccctggagaa     3120

gacgaaagcc aacatcaagt gggtgaagga gaacaaggag gtggtgctcc agtggttcac     3180

agaaaacagc aaatagtccc cagcccttga agtcacccgg cccccatgca aggtgcccac     3240

atgtgtccat cccagcggct ggtgcagggc ctccattcct ggagcccgag gcaccagtgt     3300

cctcccctca aggacaaagt ctccagccca cgttctctct gcctgtgagc cagtctagtt     3360

cctgatgacc caggctgcct gagcacctcc cagcccctgc ccctcatgcc aaccccgccc     3420

taggcctggc atggcacctg tcgcccagtg ccctggggct gatctcaggg aagcccagct     3480

ccagggccag atgagcagaa gctctcgatg gacaatgaac ggccttgctg ggggccgccc     3540

tgtaccctct ttcacctttc cctaaagacc ctaaatctga ggaatcaaca gggcagcaga     3600

tctgtatatt tttttctaag agaaaatgta aataaaggat ttctagatga aaaaaaaaaa     3660

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3720

aaaaaaaaaa aaaaaaaaaa                                                 3740


<210> 132
<211> 967
<212> PRT
<213> Homo sapiens

<220> 
<223> ANPEP (alanyl (membrane) aminopeptidase)

<400> 132
Met Ala Lys Gly Phe Tyr Ile Ser Lys Ser Leu Gly Ile Leu Gly Ile 
1               5                   10                  15      
Leu Leu Gly Val Ala Ala Val Cys Thr Ile Ile Ala Leu Ser Val Val 
            20                  25                  30          
Tyr Ser Gln Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser 
        35                  40                  45              
Thr Thr Pro Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr 
    50                  55                  60                  
Leu Asp Gln Ser Lys Ala Trp Asn Arg Tyr Arg Leu Pro Asn Thr Leu 
65                  70                  75                  80  
Lys Pro Asp Ser Tyr Arg Val Thr Leu Arg Pro Tyr Leu Thr Pro Asn 
                85                  90                  95      
Asp Arg Gly Leu Tyr Val Phe Lys Gly Ser Ser Thr Val Arg Phe Thr 
            100                 105                 110         
Cys Lys Glu Ala Thr Asp Val Ile Ile Ile His Ser Lys Lys Leu Asn 
        115                 120                 125             
Tyr Thr Leu Ser Gln Gly His Arg Val Val Leu Arg Gly Val Gly Gly 
    130                 135                 140                 
Ser Gln Pro Pro Asp Ile Asp Lys Thr Glu Leu Val Glu Pro Thr Glu 
145                 150                 155                 160 
Tyr Leu Val Val His Leu Lys Gly Ser Leu Val Lys Asp Ser Gln Tyr 
                165                 170                 175     
Glu Met Asp Ser Glu Phe Glu Gly Glu Leu Ala Asp Asp Leu Ala Gly 
            180                 185                 190         
Phe Tyr Arg Ser Glu Tyr Met Glu Gly Asn Val Arg Lys Val Val Ala 
        195                 200                 205             
Thr Thr Gln Met Gln Ala Ala Asp Ala Arg Lys Ser Phe Pro Cys Phe 
    210                 215                 220                 
Asp Glu Pro Ala Met Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro 
225                 230                 235                 240 
Lys Asp Leu Thr Ala Leu Ser Asn Met Leu Pro Lys Gly Pro Ser Thr 
                245                 250                 255     
Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr Glu Phe His Thr Thr 
            260                 265                 270         
Pro Lys Met Ser Thr Tyr Leu Leu Ala Phe Ile Val Ser Glu Phe Asp 
        275                 280                 285             
Tyr Val Glu Lys Gln Ala Ser Asn Gly Val Leu Ile Arg Ile Trp Ala 
    290                 295                 300                 
Arg Pro Ser Ala Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val 
305                 310                 315                 320 
Thr Gly Pro Ile Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr 
                325                 330                 335     
Pro Leu Pro Lys Ser Asp Gln Ile Gly Leu Pro Asp Phe Asn Ala Gly 
            340                 345                 350         
Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Asn Ser Leu Leu 
        355                 360                 365             
Phe Asp Pro Leu Ser Ser Ser Ser Ser Asn Lys Glu Arg Val Val Thr 
    370                 375                 380                 
Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr 
385                 390                 395                 400 
Ile Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Ser Tyr 
                405                 410                 415     
Val Glu Tyr Leu Gly Ala Asp Tyr Ala Glu Pro Thr Trp Asn Leu Lys 
            420                 425                 430         
Asp Leu Met Val Leu Asn Asp Val Tyr Arg Val Met Ala Val Asp Ala 
        435                 440                 445             
Leu Ala Ser Ser His Pro Leu Ser Thr Pro Ala Ser Glu Ile Asn Thr 
    450                 455                 460                 
Pro Ala Gln Ile Ser Glu Leu Phe Asp Ala Ile Ser Tyr Ser Lys Gly 
465                 470                 475                 480 
Ala Ser Val Leu Arg Met Leu Ser Ser Phe Leu Ser Glu Asp Val Phe 
                485                 490                 495     
Lys Gln Gly Leu Ala Ser Tyr Leu His Thr Phe Ala Tyr Gln Asn Thr 
            500                 505                 510         
Ile Tyr Leu Asn Leu Trp Asp His Leu Gln Glu Ala Val Asn Asn Arg 
        515                 520                 525             
Ser Ile Gln Leu Pro Thr Thr Val Arg Asp Ile Met Asn Arg Trp Thr 
    530                 535                 540                 
Leu Gln Met Gly Phe Pro Val Ile Thr Val Asp Thr Ser Thr Gly Thr 
545                 550                 555                 560 
Leu Ser Gln Glu His Phe Leu Leu Asp Pro Asp Ser Asn Val Thr Arg 
                565                 570                 575     
Pro Ser Glu Phe Asn Tyr Val Trp Ile Val Pro Ile Thr Ser Ile Arg 
            580                 585                 590         
Asp Gly Arg Gln Gln Gln Asp Tyr Trp Leu Ile Asp Val Arg Ala Gln 
        595                 600                 605             
Asn Asp Leu Phe Ser Thr Ser Gly Asn Glu Trp Val Leu Leu Asn Leu 
    610                 615                 620                 
Asn Val Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Glu Glu Asn Trp Arg 
625                 630                 635                 640 
Lys Ile Gln Thr Gln Leu Gln Arg Asp His Ser Ala Ile Pro Val Ile 
                645                 650                 655     
Asn Arg Ala Gln Ile Ile Asn Asp Ala Phe Asn Leu Ala Ser Ala His 
            660                 665                 670         
Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu 
        675                 680                 685             
Glu Arg Gln Tyr Met Pro Trp Glu Ala Ala Leu Ser Ser Leu Ser Tyr 
    690                 695                 700                 
Phe Lys Leu Met Phe Asp Arg Ser Glu Val Tyr Gly Pro Met Lys Asn 
705                 710                 715                 720 
Tyr Leu Lys Lys Gln Val Thr Pro Leu Phe Ile His Phe Arg Asn Asn 
                725                 730                 735     
Thr Asn Asn Trp Arg Glu Ile Pro Glu Asn Leu Met Asp Gln Tyr Ser 
            740                 745                 750         
Glu Val Asn Ala Ile Ser Thr Ala Cys Ser Asn Gly Val Pro Glu Cys 
        755                 760                 765             
Glu Glu Met Val Ser Gly Leu Phe Lys Gln Trp Met Glu Asn Pro Asn 
    770                 775                 780                 
Asn Asn Pro Ile His Pro Asn Leu Arg Ser Thr Val Tyr Cys Asn Ala 
785                 790                 795                 800 
Ile Ala Gln Gly Gly Glu Glu Glu Trp Asp Phe Ala Trp Glu Gln Phe 
                805                 810                 815     
Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala Ala Leu 
            820                 825                 830         
Ala Cys Ser Lys Glu Leu Trp Ile Leu Asn Arg Tyr Leu Ser Tyr Thr 
        835                 840                 845             
Leu Asn Pro Asp Leu Ile Arg Lys Gln Asp Ala Thr Ser Thr Ile Ile 
    850                 855                 860                 
Ser Ile Thr Asn Asn Val Ile Gly Gln Gly Leu Val Trp Asp Phe Val 
865                 870                 875                 880 
Gln Ser Asn Trp Lys Lys Leu Phe Asn Asp Tyr Gly Gly Gly Ser Phe 
                885                 890                 895     
Ser Phe Ser Asn Leu Ile Gln Ala Val Thr Arg Arg Phe Ser Thr Glu 
            900                 905                 910         
Tyr Glu Leu Gln Gln Leu Glu Gln Phe Lys Lys Asp Asn Glu Glu Thr 
        915                 920                 925             
Gly Phe Gly Ser Gly Thr Arg Ala Leu Glu Gln Ala Leu Glu Lys Thr 
    930                 935                 940                 
Lys Ala Asn Ile Lys Trp Val Lys Glu Asn Lys Glu Val Val Leu Gln 
945                 950                 955                 960 
Trp Phe Thr Glu Asn Ser Lys 
                965         

<210> 133
<211> 3962
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3962
<223> /mol_type="unassigned DNA"
      /note="FILIP1L (filamin A interacting protein 1-like)"
      /organism="Homo sapiens"

<400> 133
acacacacac agacgtgctc acggagcctg tgcctgcctc tacttgtctg ctctgcgcag       60

atggttcctg gcttttgggt cacctcatcc tgcagcccag tccagttaga acctttcttc      120

cacagagact ggcaagctgt ggggtaagag ttttggtaag gctgcctgtc ttcagagcat      180

gaaggacact gcccggagag ggaagagggc aatatttagt gtttgggcct acttgttgtt      240

gggctcccca ctgcctctcc tttgcagagc tatcactggc ccctggttgc aaactctcgg      300

tggctttcaa gcctacaaaa caaaaactga gagggtgtcc aaaaagagaa gaagaaaacg      360

ttgttgttgg tcctggattc cactgttgga ttttggtggg gatgagaaga aggaattacc      420

aggtgtgatc aacacctgca cggtacctgc acggctttaa agaatgcgtt ccagaggcag      480

tgataccgag ggctcagccc aaaagaaatt tccaagacat actaaaggcc acagtttcca      540

agggcctaaa aacatgaagc atagacagca agacaaagac tcccccagtg agtcggatgt      600

aatacttccg tgtcccaagg cagagaagcc acacagtggt aatggccacc aagcagaaga      660

cctctcaaga gatgacctgt tatttctcct cagcattctg gagggagaac tgcaggctcg      720

agatgaggtc ataggcattt taaaggctga aaaaatggac ctggctttgc tggaagctca      780

gtatgggttt gtcactccaa aaaaggtgtt agaggctctc cagagagatg cttttcaagc      840

gaaatctacc ccttggcagg aggacatcta tgagaaacca atgaatgagt tggacaaagt      900

tgtggaaaaa cataaagaat cttacagacg aatcctggga cagcttttag tggcagaaaa      960

atcccgtagg caaaccatat tggagttgga ggaagaaaag agaaaacata aagaatacat     1020

ggagaagagt gatgaattca tatgcctact agaacaggaa tgtgaaagat taaagaagct     1080

aattgatcaa gaaatcaagt ctcaggagga gaaggagcaa gaaaaggaga aaagggtcac     1140

caccctgaaa gaggagctga ccaagctgaa gtcttttgct ttgatggtgg tggatgaaca     1200

gcaaaggctg acggcacagc tcacccttca aagacagaaa atccaagagc tgaccacaaa     1260

tgcaaaggaa acacatacca aactagccct tgctgaagcc agagttcagg aggaagagca     1320

gaaggcaacc agactagaga aggaactgca aacgcagacc acaaagtttc accaagacca     1380

agacacaatt atggcgaagc tcaccaatga ggacagtcaa aatcgccagc ttcaacaaaa     1440

gctggcagca ctcagccggc agattgatga gttagaagag acaaacaggt ctttacgaaa     1500

agcagaagag gagctgcaag atataaaaga aaaaatcagt aagggagaat atggaaacgc     1560

tggtatcatg gctgaagtgg aagagctcag gaaacgtgtg ctagatatgg aagggaaaga     1620

tgaagagctc ataaaaatgg aggagcagtg cagagatctc aataagaggc ttgaaaggga     1680

gacgttacag agtaaagact ttaaactaga ggttgaaaaa ctcagtaaaa gaattatggc     1740

tctggaaaag ttagaagacg ctttcaacaa aagcaaacaa gaatgctact ctctgaaatg     1800

caatttagaa aaagaaagga tgaccacaaa gcagttgtct caagaactgg agagtttaaa     1860

agtaaggatc aaagagctag aagccattga aagtcggcta gaaaagacag aattcactct     1920

aaaagaggat ttaactaaac tgaaaacatt aactgtgatg tttgtagatg aacggaaaac     1980

aatgagtgaa aaattaaaga aaactgaaga taaattacaa gctgcttctt ctcagcttca     2040

agtggagcaa aataaagtaa caacagttac tgagaagtta attgaggaaa ctaaaagggc     2100

gctcaagtcc aaaaccgatg tagaagaaaa gatgtacagc gtaaccaagg agagagatga     2160

tttaaaaaac aaattgaaag cggaagaaga gaaaggaaat gatctcctgt caagagttaa     2220

tatgttgaaa aataggcttc aatcattgga agcaattgag aaagatttcc taaaaaacaa     2280

attaaatcaa gactctggga aatccacaac agcattacac caagaaaaca ataagattaa     2340

ggagctctct caagaagtgg aaagactgaa actgaagcta aaggacatga aagccattga     2400

ggatgacctc atgaaaacag aagatgaata tgagactcta gaacgaaggt atgctaatga     2460

acgagacaaa gctcaatttt tatctaaaga gctagaacat gttaaaatgg aacttgctaa     2520

gtacaagtta gcagaaaaga cagagaccag ccatgaacaa tggcttttca aaaggcttca     2580

agaagaagaa gctaagtcag ggcacctctc aagagaagtg gatgcattaa aagagaaaat     2640

tcatgaatac atggcaactg aagacctaat atgtcacctc cagggagatc actcagtcct     2700

gcaaaaaaaa ctaaatcaac aagaaaacag gaacagagat ttaggaagag agattgaaaa     2760

cctcactaag gagttagaga ggtaccggca tttcagtaag agcctcaggc ctagtctcaa     2820

tggaagaaga atttccgatc ctcaagtatt ttctaaagaa gttcagacag aagcagtaga     2880

caatgaacca cctgattaca agagcctcat tcctctggaa cgtgcagtca tcaatggtca     2940

gttatatgag gagagtgaga atcaagacga ggaccctaat gatgagggat ctgtgctgtc     3000

cttcaaatgc agccagtcta ctccatgtcc tgttaacaga aagctatgga ttccctggat     3060

gaaatccaag gagggccatc ttcagaatgg aaaaatgcaa actaaaccca atgccaactt     3120

tgtgcaacct ggagatctag tcctaagcca cacacctggg cagccacttc atataaaggt     3180

tactccagac catgtacaaa acacagccac tcttgaaatc acaagtccaa ccacagagag     3240

tcctcactct tacacgagta ctgcagtgat accgaactgt ggcacgccaa agcaaaggat     3300

aaccatcctc caaaacgcct ccataacacc agtaaagtcc aaaacctcta ccgaagacct     3360

catgaattta gaacaaggca tgtccccaat taccatggca acctttgcca gagcacagac     3420

cccagagtct tgtggttctc taactccaga aaggacaatg tcccctattc aggttttggc     3480

tgtgactggt tcagctagct ctcctgagca gggacgctcc ccagaaccaa cagaaatcag     3540

tgccaagcat gcgatattca gagtctcccc agaccggcag tcatcatggc agtttcagcg     3600

ttcaaacagc aatagctcaa gtgtgataac tactgaggat aataaaatcc acattcactt     3660

aggaagtcct tacatgcaag ctgtagccag ccctgtgaga cctgccagcc cttcagcacc     3720

actgcaggat aaccgaactc aaggcttaat taacggggca ctaaacaaaa caaccaataa     3780

agtcaccagc agtattacta tcacaccaac agccacacct cttcctcgac aatcacaaat     3840

tacagtggaa ccacttcttc tgcctcattg aactcaacat ccttcagact tttaaggcat     3900

tccaaatccc agtcttcatg ttgaactggg ttaagcattt attaaaaaat cgttttcttc     3960

ta                                                                    3962


<210> 134
<211> 3274
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3274
<223> /mol_type="unassigned DNA"
      /note="FILIP1L (filamin A interacting protein 1-like)"
      /organism="Homo sapiens"

<400> 134
ataggccggg cgcgctcagc gccccgctcg cattgttcgg gcgactctcg gagcgcgcac       60

agtcggctcg cagcgcggca ctacagcggc cccggcccgg cccccgcccg gccccggcgc      120

aggcagttca gattaaagaa gctaattgat caagaaatca agtctcagga ggagaaggag      180

caagaaaagg agaaaagggt caccaccctg aaagaggagc tgaccaagct gaagtctttt      240

gctttgatgg tggtggatga acagcaaagg ctgacggcac agctcaccct tcaaagacag      300

aaaatccaag agctgaccac aaatgcaaag gaaacacata ccaaactagc ccttgctgaa      360

gccagagttc aggaggaaga gcagaaggca accagactag agaaggaact gcaaacgcag      420

accacaaagt ttcaccaaga ccaagacaca attatggcga agctcaccaa tgaggacagt      480

caaaatcgcc agcttcaaca aaagctggca gcactcagcc ggcagattga tgagttagaa      540

gagacaaaca ggtctttacg aaaagcagaa gaggagctgc aagatataaa agaaaaaatc      600

agtaagggag aatatggaaa cgctggtatc atggctgaag tggaagagct caggaaacgt      660

gtgctagata tggaagggaa agatgaagag ctcataaaaa tggaggagca gtgcagagat      720

ctcaataaga ggcttgaaag ggagacgtta cagagtaaag actttaaact agaggttgaa      780

aaactcagta aaagaattat ggctctggaa aagttagaag acgctttcaa caaaagcaaa      840

caagaatgct actctctgaa atgcaattta gaaaaagaaa ggatgaccac aaagcagttg      900

tctcaagaac tggagagttt aaaagtaagg atcaaagagc tagaagccat tgaaagtcgg      960

ctagaaaaga cagaattcac tctaaaagag gatttaacta aactgaaaac attaactgtg     1020

atgtttgtag atgaacggaa aacaatgagt gaaaaattaa agaaaactga agataaatta     1080

caagctgctt cttctcagct tcaagtggag caaaataaag taacaacagt tactgagaag     1140

ttaattgagg aaactaaaag ggcgctcaag tccaaaaccg atgtagaaga aaagatgtac     1200

agcgtaacca aggagagaga tgatttaaaa aacaaattga aagcggaaga agagaaagga     1260

aatgatctcc tgtcaagagt taatatgttg aaaaataggc ttcaatcatt ggaagcaatt     1320

gagaaagatt tcctaaaaaa caaattaaat caagactctg ggaaatccac aacagcatta     1380

caccaagaaa acaataagat taaggagctc tctcaagaag tggaaagact gaaactgaag     1440

ctaaaggaca tgaaagccat tgaggatgac ctcatgaaaa cagaagatga atatgagact     1500

ctagaacgaa ggtatgctaa tgaacgagac aaagctcaat ttttatctaa agagctagaa     1560

catgttaaaa tggaacttgc taagtacaag ttagcagaaa agacagagac cagccatgaa     1620

caatggcttt tcaaaaggct tcaagaagaa gaagctaagt cagggcacct ctcaagagaa     1680

gtggatgcat taaaagagaa aattcatgaa tacatggcaa ctgaagacct aatatgtcac     1740

ctccagggag atcactcagt cctgcaaaaa aaactaaatc aacaagaaaa caggaacaga     1800

gatttaggaa gagagattga aaacctcact aaggagttag agaggtaccg gcatttcagt     1860

aagagcctca ggcctagtct caatggaaga agaatttccg atcctcaagt attttctaaa     1920

gaagttcaga cagaagcagt agacaatgaa ccacctgatt acaagagcct cattcctctg     1980

gaacgtgcag tcatcaatgg tcagttatat gaggagagtg agaatcaaga cgaggaccct     2040

aatgatgagg gatctgtgct gtccttcaaa tgcagccagt ctactccatg tcctgttaac     2100

agaaagctat ggattccctg gatgaaatcc aaggagggcc atcttcagaa tggaaaaatg     2160

caaactaaac ccaatgccaa ctttgtgcaa cctggagatc tagtcctaag ccacacacct     2220

gggcagccac ttcatataaa ggttactcca gaccatgtac aaaacacagc cactcttgaa     2280

atcacaagtc caaccacaga gagtcctcac tcttacacga gtactgcagt gataccgaac     2340

tgtggcacgc caaagcaaag gataaccatc ctccaaaacg cctccataac accagtaaag     2400

tccaaaacct ctaccgaaga cctcatgaat ttagaacaag gcatgtcccc aattaccatg     2460

gcaacctttg ccagagcaca gaccccagag tcttgtggtt ctctaactcc agaaaggaca     2520

atgtccccta ttcaggtttt ggctgtgact ggttcagcta gctctcctga gcagggacgc     2580

tccccagaac caacagaaat cagtgccaag catgcgatat tcagagtctc cccagaccgg     2640

cagtcatcat ggcagtttca gcgttcaaac agcaatagct caagtgtgat aactactgag     2700

gataataaaa tccacattca cttaggaagt ccttacatgc aagctgtagc cagccctgtg     2760

agacctgcca gcccttcagc accactgcag gataaccgaa ctcaaggctt aattaacggg     2820

gcactaaaca aaacaaccaa taaagtcacc agcagtatta ctatcacacc aacagccaca     2880

cctcttcctc gacaatcaca aattacagta agtaatatat ataactgacc acgctcaccc     2940

tcatccagtc catactgata tttttgcaag gaactcaatc cttttttaat catccctcca     3000

tatcccccaa gactgactga actcgtactt tgggaaggtt tgtgcatgaa ctatacaaga     3060

gtatctgaaa ctaactgttg cctgcatagt catatcgagt gtgcacttac tgtatatctt     3120

ttcatttaca tacttgtatg gaaaatattt agtctgcact tgtataaata catctttatg     3180

tatttcattt tccataactc actttaattt gactgcaact tgtcttggtg aaatacttta     3240

acattataaa acagtaaata atttgttatt ttta                                 3274


<210> 135
<211> 4211
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..4211
<223> /mol_type="unassigned DNA"
      /note="FILIP1L (filamin A interacting protein 1-like)"
      /organism="Homo sapiens"

<400> 135
acacacacac agacgtgctc acggagcctg tgcctgcctc tacttgtctg ctctgcgcag       60

atggttcctg gcttttgggt cacctcatcc tgcagcccag tccagttaga acctttcttc      120

cacagagact ggcaagctgt ggggtaagag ttttggtaag gctgcctgtc ttcagagcat      180

gaaggacact gcccggagag ggaagagggc aatatttagt gtttgggcct acttgttgtt      240

gggctcccca ctgcctctcc tttgcagagc tatcactggc ccctggttgc aaactctcgg      300

tggctttcaa gcctacaaaa caaaaactga gagggtgtcc aaaaagagaa gaagaaaacg      360

ttgttgttgg tcctggattc cactgttgga ttttggtggg gatgagaaga aggaattacc      420

aggtgtgatc aacacctgca cggtacctgc acggctttaa agaatgcgtt ccagaggcag      480

tgataccgag ggctcagccc aaaagaaatt tccaagacat actaaaggcc acagtttcca      540

agggcctaaa aacatgaagc atagacagca agacaaagac tcccccagtg agtcggatgt      600

aatacttccg tgtcccaagg cagagaagcc acacagtggt aatggccacc aagcagaaga      660

cctctcaaga gatgacctgt tatttctcct cagcattctg gagggagaac tgcaggctcg      720

agatgaggtc ataggcattt taaaggctga aaaaatggac ctggctttgc tggaagctca      780

gtatgggttt gtcactccaa aaaaggtgtt agaggctctc cagagagatg cttttcaagc      840

gaaatctacc ccttggcagg aggacatcta tgagaaacca atgaatgagt tggacaaagt      900

tgtggaaaaa cataaagaat cttacagacg aatcctggga cagcttttag tggcagaaaa      960

atcccgtagg caaaccatat tggagttgga ggaagaaaag agaaaacata aagaatacat     1020

ggagaagagt gatgaattca tatgcctact agaacaggaa tgtgaaagat taaagaagct     1080

aattgatcaa gaaatcaagt ctcaggagga gaaggagcaa gaaaaggaga aaagggtcac     1140

caccctgaaa gaggagctga ccaagctgaa gtcttttgct ttgatggtgg tggatgaaca     1200

gcaaaggctg acggcacagc tcacccttca aagacagaaa atccaagagc tgaccacaaa     1260

tgcaaaggaa acacatacca aactagccct tgctgaagcc agagttcagg aggaagagca     1320

gaaggcaacc agactagaga aggaactgca aacgcagacc acaaagtttc accaagacca     1380

agacacaatt atggcgaagc tcaccaatga ggacagtcaa aatcgccagc ttcaacaaaa     1440

gctggcagca ctcagccggc agattgatga gttagaagag acaaacaggt ctttacgaaa     1500

agcagaagag gagctgcaag atataaaaga aaaaatcagt aagggagaat atggaaacgc     1560

tggtatcatg gctgaagtgg aagagctcag gaaacgtgtg ctagatatgg aagggaaaga     1620

tgaagagctc ataaaaatgg aggagcagtg cagagatctc aataagaggc ttgaaaggga     1680

gacgttacag agtaaagact ttaaactaga ggttgaaaaa ctcagtaaaa gaattatggc     1740

tctggaaaag ttagaagacg ctttcaacaa aagcaaacaa gaatgctact ctctgaaatg     1800

caatttagaa aaagaaagga tgaccacaaa gcagttgtct caagaactgg agagtttaaa     1860

agtaaggatc aaagagctag aagccattga aagtcggcta gaaaagacag aattcactct     1920

aaaagaggat ttaactaaac tgaaaacatt aactgtgatg tttgtagatg aacggaaaac     1980

aatgagtgaa aaattaaaga aaactgaaga taaattacaa gctgcttctt ctcagcttca     2040

agtggagcaa aataaagtaa caacagttac tgagaagtta attgaggaaa ctaaaagggc     2100

gctcaagtcc aaaaccgatg tagaagaaaa gatgtacagc gtaaccaagg agagagatga     2160

tttaaaaaac aaattgaaag cggaagaaga gaaaggaaat gatctcctgt caagagttaa     2220

tatgttgaaa aataggcttc aatcattgga agcaattgag aaagatttcc taaaaaacaa     2280

attaaatcaa gactctggga aatccacaac agcattacac caagaaaaca ataagattaa     2340

ggagctctct caagaagtgg aaagactgaa actgaagcta aaggacatga aagccattga     2400

ggatgacctc atgaaaacag aagatgaata tgagactcta gaacgaaggt atgctaatga     2460

acgagacaaa gctcaatttt tatctaaaga gctagaacat gttaaaatgg aacttgctaa     2520

gtacaagtta gcagaaaaga cagagaccag ccatgaacaa tggcttttca aaaggcttca     2580

agaagaagaa gctaagtcag ggcacctctc aagagaagtg gatgcattaa aagagaaaat     2640

tcatgaatac atggcaactg aagacctaat atgtcacctc cagggagatc actcagtcct     2700

gcaaaaaaaa ctaaatcaac aagaaaacag gaacagagat ttaggaagag agattgaaaa     2760

cctcactaag gagttagaga ggtaccggca tttcagtaag agcctcaggc ctagtctcaa     2820

tggaagaaga atttccgatc ctcaagtatt ttctaaagaa gttcagacag aagcagtaga     2880

caatgaacca cctgattaca agagcctcat tcctctggaa cgtgcagtca tcaatggtca     2940

gttatatgag gagagtgaga atcaagacga ggaccctaat gatgagggat ctgtgctgtc     3000

cttcaaatgc agccagtcta ctccatgtcc tgttaacaga aagctatgga ttccctggat     3060

gaaatccaag gagggccatc ttcagaatgg aaaaatgcaa actaaaccca atgccaactt     3120

tgtgcaacct ggagatctag tcctaagcca cacacctggg cagccacttc atataaaggt     3180

tactccagac catgtacaaa acacagccac tcttgaaatc acaagtccaa ccacagagag     3240

tcctcactct tacacgagta ctgcagtgat accgaactgt ggcacgccaa agcaaaggat     3300

aaccatcctc caaaacgcct ccataacacc agtaaagtcc aaaacctcta ccgaagacct     3360

catgaattta gaacaaggca tgtccccaat taccatggca acctttgcca gagcacagac     3420

cccagagtct tgtggttctc taactccaga aaggacaatg tcccctattc aggttttggc     3480

tgtgactggt tcagctagct ctcctgagca gggacgctcc ccagaaccaa cagaaatcag     3540

tgccaagcat gcgatattca gagtctcccc agaccggcag tcatcatggc agtttcagcg     3600

ttcaaacagc aatagctcaa gtgtgataac tactgaggat aataaaatcc acattcactt     3660

aggaagtcct tacatgcaag ctgtagccag ccctgtgaga cctgccagcc cttcagcacc     3720

actgcaggat aaccgaactc aaggcttaat taacggggca ctaaacaaaa caaccaataa     3780

agtcaccagc agtattacta tcacaccaac agccacacct cttcctcgac aatcacaaat     3840

tacagtaagt aatatatata actgaccacg ctcaccctca tccagtccat actgatattt     3900

ttgcaaggaa ctcaatcctt ttttaatcat ccctccatat cccccaagac tgactgaact     3960

cgtactttgg gaaggtttgt gcatgaacta tacaagagta tctgaaacta actgttgcct     4020

gcatagtcat atcgagtgtg cacttactgt atatcttttc atttacatac ttgtatggaa     4080

aatatttagt ctgcacttgt ataaatacat ctttatgtat ttcattttcc ataactcact     4140

ttaatttgac tgcaacttgt cttggtgaaa tactttaaca ttataaaaca gtaaataatt     4200

tgttattttt a                                                          4211


<210> 136
<211> 1135
<212> PRT
<213> Homo sapiens

<220> 
<223> FILIP1L (filamin A interacting protein 1-like)

<400> 136
Met Arg Ser Arg Gly Ser Asp Thr Glu Gly Ser Ala Gln Lys Lys Phe 
1               5                   10                  15      
Pro Arg His Thr Lys Gly His Ser Phe Gln Gly Pro Lys Asn Met Lys 
            20                  25                  30          
His Arg Gln Gln Asp Lys Asp Ser Pro Ser Glu Ser Asp Val Ile Leu 
        35                  40                  45              
Pro Cys Pro Lys Ala Glu Lys Pro His Ser Gly Asn Gly His Gln Ala 
    50                  55                  60                  
Glu Asp Leu Ser Arg Asp Asp Leu Leu Phe Leu Leu Ser Ile Leu Glu 
65                  70                  75                  80  
Gly Glu Leu Gln Ala Arg Asp Glu Val Ile Gly Ile Leu Lys Ala Glu 
                85                  90                  95      
Lys Met Asp Leu Ala Leu Leu Glu Ala Gln Tyr Gly Phe Val Thr Pro 
            100                 105                 110         
Lys Lys Val Leu Glu Ala Leu Gln Arg Asp Ala Phe Gln Ala Lys Ser 
        115                 120                 125             
Thr Pro Trp Gln Glu Asp Ile Tyr Glu Lys Pro Met Asn Glu Leu Asp 
    130                 135                 140                 
Lys Val Val Glu Lys His Lys Glu Ser Tyr Arg Arg Ile Leu Gly Gln 
145                 150                 155                 160 
Leu Leu Val Ala Glu Lys Ser Arg Arg Gln Thr Ile Leu Glu Leu Glu 
                165                 170                 175     
Glu Glu Lys Arg Lys His Lys Glu Tyr Met Glu Lys Ser Asp Glu Phe 
            180                 185                 190         
Ile Cys Leu Leu Glu Gln Glu Cys Glu Arg Leu Lys Lys Leu Ile Asp 
        195                 200                 205             
Gln Glu Ile Lys Ser Gln Glu Glu Lys Glu Gln Glu Lys Glu Lys Arg 
    210                 215                 220                 
Val Thr Thr Leu Lys Glu Glu Leu Thr Lys Leu Lys Ser Phe Ala Leu 
225                 230                 235                 240 
Met Val Val Asp Glu Gln Gln Arg Leu Thr Ala Gln Leu Thr Leu Gln 
                245                 250                 255     
Arg Gln Lys Ile Gln Glu Leu Thr Thr Asn Ala Lys Glu Thr His Thr 
            260                 265                 270         
Lys Leu Ala Leu Ala Glu Ala Arg Val Gln Glu Glu Glu Gln Lys Ala 
        275                 280                 285             
Thr Arg Leu Glu Lys Glu Leu Gln Thr Gln Thr Thr Lys Phe His Gln 
    290                 295                 300                 
Asp Gln Asp Thr Ile Met Ala Lys Leu Thr Asn Glu Asp Ser Gln Asn 
305                 310                 315                 320 
Arg Gln Leu Gln Gln Lys Leu Ala Ala Leu Ser Arg Gln Ile Asp Glu 
                325                 330                 335     
Leu Glu Glu Thr Asn Arg Ser Leu Arg Lys Ala Glu Glu Glu Leu Gln 
            340                 345                 350         
Asp Ile Lys Glu Lys Ile Ser Lys Gly Glu Tyr Gly Asn Ala Gly Ile 
        355                 360                 365             
Met Ala Glu Val Glu Glu Leu Arg Lys Arg Val Leu Asp Met Glu Gly 
    370                 375                 380                 
Lys Asp Glu Glu Leu Ile Lys Met Glu Glu Gln Cys Arg Asp Leu Asn 
385                 390                 395                 400 
Lys Arg Leu Glu Arg Glu Thr Leu Gln Ser Lys Asp Phe Lys Leu Glu 
                405                 410                 415     
Val Glu Lys Leu Ser Lys Arg Ile Met Ala Leu Glu Lys Leu Glu Asp 
            420                 425                 430         
Ala Phe Asn Lys Ser Lys Gln Glu Cys Tyr Ser Leu Lys Cys Asn Leu 
        435                 440                 445             
Glu Lys Glu Arg Met Thr Thr Lys Gln Leu Ser Gln Glu Leu Glu Ser 
    450                 455                 460                 
Leu Lys Val Arg Ile Lys Glu Leu Glu Ala Ile Glu Ser Arg Leu Glu 
465                 470                 475                 480 
Lys Thr Glu Phe Thr Leu Lys Glu Asp Leu Thr Lys Leu Lys Thr Leu 
                485                 490                 495     
Thr Val Met Phe Val Asp Glu Arg Lys Thr Met Ser Glu Lys Leu Lys 
            500                 505                 510         
Lys Thr Glu Asp Lys Leu Gln Ala Ala Ser Ser Gln Leu Gln Val Glu 
        515                 520                 525             
Gln Asn Lys Val Thr Thr Val Thr Glu Lys Leu Ile Glu Glu Thr Lys 
    530                 535                 540                 
Arg Ala Leu Lys Ser Lys Thr Asp Val Glu Glu Lys Met Tyr Ser Val 
545                 550                 555                 560 
Thr Lys Glu Arg Asp Asp Leu Lys Asn Lys Leu Lys Ala Glu Glu Glu 
                565                 570                 575     
Lys Gly Asn Asp Leu Leu Ser Arg Val Asn Met Leu Lys Asn Arg Leu 
            580                 585                 590         
Gln Ser Leu Glu Ala Ile Glu Lys Asp Phe Leu Lys Asn Lys Leu Asn 
        595                 600                 605             
Gln Asp Ser Gly Lys Ser Thr Thr Ala Leu His Gln Glu Asn Asn Lys 
    610                 615                 620                 
Ile Lys Glu Leu Ser Gln Glu Val Glu Arg Leu Lys Leu Lys Leu Lys 
625                 630                 635                 640 
Asp Met Lys Ala Ile Glu Asp Asp Leu Met Lys Thr Glu Asp Glu Tyr 
                645                 650                 655     
Glu Thr Leu Glu Arg Arg Tyr Ala Asn Glu Arg Asp Lys Ala Gln Phe 
            660                 665                 670         
Leu Ser Lys Glu Leu Glu His Val Lys Met Glu Leu Ala Lys Tyr Lys 
        675                 680                 685             
Leu Ala Glu Lys Thr Glu Thr Ser His Glu Gln Trp Leu Phe Lys Arg 
    690                 695                 700                 
Leu Gln Glu Glu Glu Ala Lys Ser Gly His Leu Ser Arg Glu Val Asp 
705                 710                 715                 720 
Ala Leu Lys Glu Lys Ile His Glu Tyr Met Ala Thr Glu Asp Leu Ile 
                725                 730                 735     
Cys His Leu Gln Gly Asp His Ser Val Leu Gln Lys Lys Leu Asn Gln 
            740                 745                 750         
Gln Glu Asn Arg Asn Arg Asp Leu Gly Arg Glu Ile Glu Asn Leu Thr 
        755                 760                 765             
Lys Glu Leu Glu Arg Tyr Arg His Phe Ser Lys Ser Leu Arg Pro Ser 
    770                 775                 780                 
Leu Asn Gly Arg Arg Ile Ser Asp Pro Gln Val Phe Ser Lys Glu Val 
785                 790                 795                 800 
Gln Thr Glu Ala Val Asp Asn Glu Pro Pro Asp Tyr Lys Ser Leu Ile 
                805                 810                 815     
Pro Leu Glu Arg Ala Val Ile Asn Gly Gln Leu Tyr Glu Glu Ser Glu 
            820                 825                 830         
Asn Gln Asp Glu Asp Pro Asn Asp Glu Gly Ser Val Leu Ser Phe Lys 
        835                 840                 845             
Cys Ser Gln Ser Thr Pro Cys Pro Val Asn Arg Lys Leu Trp Ile Pro 
    850                 855                 860                 
Trp Met Lys Ser Lys Glu Gly His Leu Gln Asn Gly Lys Met Gln Thr 
865                 870                 875                 880 
Lys Pro Asn Ala Asn Phe Val Gln Pro Gly Asp Leu Val Leu Ser His 
                885                 890                 895     
Thr Pro Gly Gln Pro Leu His Ile Lys Val Thr Pro Asp His Val Gln 
            900                 905                 910         
Asn Thr Ala Thr Leu Glu Ile Thr Ser Pro Thr Thr Glu Ser Pro His 
        915                 920                 925             
Ser Tyr Thr Ser Thr Ala Val Ile Pro Asn Cys Gly Thr Pro Lys Gln 
    930                 935                 940                 
Arg Ile Thr Ile Leu Gln Asn Ala Ser Ile Thr Pro Val Lys Ser Lys 
945                 950                 955                 960 
Thr Ser Thr Glu Asp Leu Met Asn Leu Glu Gln Gly Met Ser Pro Ile 
                965                 970                 975     
Thr Met Ala Thr Phe Ala Arg Ala Gln Thr Pro Glu Ser Cys Gly Ser 
            980                 985                 990         
Leu Thr Pro Glu Arg Thr Met Ser Pro Ile Gln Val Leu Ala Val Thr 
        995                 1000                1005            
Gly Ser Ala Ser Ser Pro Glu Gln Gly Arg Ser Pro Glu Pro Thr Glu 
    1010                1015                1020                
Ile Ser Ala Lys His Ala Ile Phe Arg Val Ser Pro Asp Arg Gln Ser 
1025                1030                1035                1040
Ser Trp Gln Phe Gln Arg Ser Asn Ser Asn Ser Ser Ser Val Ile Thr 
                1045                1050                1055    
Thr Glu Asp Asn Lys Ile His Ile His Leu Gly Ser Pro Tyr Met Gln 
            1060                1065                1070        
Ala Val Ala Ser Pro Val Arg Pro Ala Ser Pro Ser Ala Pro Leu Gln 
        1075                1080                1085            
Asp Asn Arg Thr Gln Gly Leu Ile Asn Gly Ala Leu Asn Lys Thr Thr 
    1090                1095                1100                
Asn Lys Val Thr Ser Ser Ile Thr Ile Thr Pro Thr Ala Thr Pro Leu 
1105                1110                1115                1120
Pro Arg Gln Ser Gln Ile Thr Val Glu Pro Leu Leu Leu Pro His 
                1125                1130                1135

<210> 137
<211> 893
<212> PRT
<213> Homo sapiens

<220> 
<223> FILIP1L (filamin A interacting protein 1-like)

<400> 137
Met Val Val Asp Glu Gln Gln Arg Leu Thr Ala Gln Leu Thr Leu Gln 
1               5                   10                  15      
Arg Gln Lys Ile Gln Glu Leu Thr Thr Asn Ala Lys Glu Thr His Thr 
            20                  25                  30          
Lys Leu Ala Leu Ala Glu Ala Arg Val Gln Glu Glu Glu Gln Lys Ala 
        35                  40                  45              
Thr Arg Leu Glu Lys Glu Leu Gln Thr Gln Thr Thr Lys Phe His Gln 
    50                  55                  60                  
Asp Gln Asp Thr Ile Met Ala Lys Leu Thr Asn Glu Asp Ser Gln Asn 
65                  70                  75                  80  
Arg Gln Leu Gln Gln Lys Leu Ala Ala Leu Ser Arg Gln Ile Asp Glu 
                85                  90                  95      
Leu Glu Glu Thr Asn Arg Ser Leu Arg Lys Ala Glu Glu Glu Leu Gln 
            100                 105                 110         
Asp Ile Lys Glu Lys Ile Ser Lys Gly Glu Tyr Gly Asn Ala Gly Ile 
        115                 120                 125             
Met Ala Glu Val Glu Glu Leu Arg Lys Arg Val Leu Asp Met Glu Gly 
    130                 135                 140                 
Lys Asp Glu Glu Leu Ile Lys Met Glu Glu Gln Cys Arg Asp Leu Asn 
145                 150                 155                 160 
Lys Arg Leu Glu Arg Glu Thr Leu Gln Ser Lys Asp Phe Lys Leu Glu 
                165                 170                 175     
Val Glu Lys Leu Ser Lys Arg Ile Met Ala Leu Glu Lys Leu Glu Asp 
            180                 185                 190         
Ala Phe Asn Lys Ser Lys Gln Glu Cys Tyr Ser Leu Lys Cys Asn Leu 
        195                 200                 205             
Glu Lys Glu Arg Met Thr Thr Lys Gln Leu Ser Gln Glu Leu Glu Ser 
    210                 215                 220                 
Leu Lys Val Arg Ile Lys Glu Leu Glu Ala Ile Glu Ser Arg Leu Glu 
225                 230                 235                 240 
Lys Thr Glu Phe Thr Leu Lys Glu Asp Leu Thr Lys Leu Lys Thr Leu 
                245                 250                 255     
Thr Val Met Phe Val Asp Glu Arg Lys Thr Met Ser Glu Lys Leu Lys 
            260                 265                 270         
Lys Thr Glu Asp Lys Leu Gln Ala Ala Ser Ser Gln Leu Gln Val Glu 
        275                 280                 285             
Gln Asn Lys Val Thr Thr Val Thr Glu Lys Leu Ile Glu Glu Thr Lys 
    290                 295                 300                 
Arg Ala Leu Lys Ser Lys Thr Asp Val Glu Glu Lys Met Tyr Ser Val 
305                 310                 315                 320 
Thr Lys Glu Arg Asp Asp Leu Lys Asn Lys Leu Lys Ala Glu Glu Glu 
                325                 330                 335     
Lys Gly Asn Asp Leu Leu Ser Arg Val Asn Met Leu Lys Asn Arg Leu 
            340                 345                 350         
Gln Ser Leu Glu Ala Ile Glu Lys Asp Phe Leu Lys Asn Lys Leu Asn 
        355                 360                 365             
Gln Asp Ser Gly Lys Ser Thr Thr Ala Leu His Gln Glu Asn Asn Lys 
    370                 375                 380                 
Ile Lys Glu Leu Ser Gln Glu Val Glu Arg Leu Lys Leu Lys Leu Lys 
385                 390                 395                 400 
Asp Met Lys Ala Ile Glu Asp Asp Leu Met Lys Thr Glu Asp Glu Tyr 
                405                 410                 415     
Glu Thr Leu Glu Arg Arg Tyr Ala Asn Glu Arg Asp Lys Ala Gln Phe 
            420                 425                 430         
Leu Ser Lys Glu Leu Glu His Val Lys Met Glu Leu Ala Lys Tyr Lys 
        435                 440                 445             
Leu Ala Glu Lys Thr Glu Thr Ser His Glu Gln Trp Leu Phe Lys Arg 
    450                 455                 460                 
Leu Gln Glu Glu Glu Ala Lys Ser Gly His Leu Ser Arg Glu Val Asp 
465                 470                 475                 480 
Ala Leu Lys Glu Lys Ile His Glu Tyr Met Ala Thr Glu Asp Leu Ile 
                485                 490                 495     
Cys His Leu Gln Gly Asp His Ser Val Leu Gln Lys Lys Leu Asn Gln 
            500                 505                 510         
Gln Glu Asn Arg Asn Arg Asp Leu Gly Arg Glu Ile Glu Asn Leu Thr 
        515                 520                 525             
Lys Glu Leu Glu Arg Tyr Arg His Phe Ser Lys Ser Leu Arg Pro Ser 
    530                 535                 540                 
Leu Asn Gly Arg Arg Ile Ser Asp Pro Gln Val Phe Ser Lys Glu Val 
545                 550                 555                 560 
Gln Thr Glu Ala Val Asp Asn Glu Pro Pro Asp Tyr Lys Ser Leu Ile 
                565                 570                 575     
Pro Leu Glu Arg Ala Val Ile Asn Gly Gln Leu Tyr Glu Glu Ser Glu 
            580                 585                 590         
Asn Gln Asp Glu Asp Pro Asn Asp Glu Gly Ser Val Leu Ser Phe Lys 
        595                 600                 605             
Cys Ser Gln Ser Thr Pro Cys Pro Val Asn Arg Lys Leu Trp Ile Pro 
    610                 615                 620                 
Trp Met Lys Ser Lys Glu Gly His Leu Gln Asn Gly Lys Met Gln Thr 
625                 630                 635                 640 
Lys Pro Asn Ala Asn Phe Val Gln Pro Gly Asp Leu Val Leu Ser His 
                645                 650                 655     
Thr Pro Gly Gln Pro Leu His Ile Lys Val Thr Pro Asp His Val Gln 
            660                 665                 670         
Asn Thr Ala Thr Leu Glu Ile Thr Ser Pro Thr Thr Glu Ser Pro His 
        675                 680                 685             
Ser Tyr Thr Ser Thr Ala Val Ile Pro Asn Cys Gly Thr Pro Lys Gln 
    690                 695                 700                 
Arg Ile Thr Ile Leu Gln Asn Ala Ser Ile Thr Pro Val Lys Ser Lys 
705                 710                 715                 720 
Thr Ser Thr Glu Asp Leu Met Asn Leu Glu Gln Gly Met Ser Pro Ile 
                725                 730                 735     
Thr Met Ala Thr Phe Ala Arg Ala Gln Thr Pro Glu Ser Cys Gly Ser 
            740                 745                 750         
Leu Thr Pro Glu Arg Thr Met Ser Pro Ile Gln Val Leu Ala Val Thr 
        755                 760                 765             
Gly Ser Ala Ser Ser Pro Glu Gln Gly Arg Ser Pro Glu Pro Thr Glu 
    770                 775                 780                 
Ile Ser Ala Lys His Ala Ile Phe Arg Val Ser Pro Asp Arg Gln Ser 
785                 790                 795                 800 
Ser Trp Gln Phe Gln Arg Ser Asn Ser Asn Ser Ser Ser Val Ile Thr 
                805                 810                 815     
Thr Glu Asp Asn Lys Ile His Ile His Leu Gly Ser Pro Tyr Met Gln 
            820                 825                 830         
Ala Val Ala Ser Pro Val Arg Pro Ala Ser Pro Ser Ala Pro Leu Gln 
        835                 840                 845             
Asp Asn Arg Thr Gln Gly Leu Ile Asn Gly Ala Leu Asn Lys Thr Thr 
    850                 855                 860                 
Asn Lys Val Thr Ser Ser Ile Thr Ile Thr Pro Thr Ala Thr Pro Leu 
865                 870                 875                 880 
Pro Arg Gln Ser Gln Ile Thr Val Ser Asn Ile Tyr Asn 
                885                 890             

<210> 138
<211> 1133
<212> PRT
<213> Homo sapiens

<220> 
<223> FILIP1L (filamin A interacting protein 1-like)

<400> 138
Met Arg Ser Arg Gly Ser Asp Thr Glu Gly Ser Ala Gln Lys Lys Phe 
1               5                   10                  15      
Pro Arg His Thr Lys Gly His Ser Phe Gln Gly Pro Lys Asn Met Lys 
            20                  25                  30          
His Arg Gln Gln Asp Lys Asp Ser Pro Ser Glu Ser Asp Val Ile Leu 
        35                  40                  45              
Pro Cys Pro Lys Ala Glu Lys Pro His Ser Gly Asn Gly His Gln Ala 
    50                  55                  60                  
Glu Asp Leu Ser Arg Asp Asp Leu Leu Phe Leu Leu Ser Ile Leu Glu 
65                  70                  75                  80  
Gly Glu Leu Gln Ala Arg Asp Glu Val Ile Gly Ile Leu Lys Ala Glu 
                85                  90                  95      
Lys Met Asp Leu Ala Leu Leu Glu Ala Gln Tyr Gly Phe Val Thr Pro 
            100                 105                 110         
Lys Lys Val Leu Glu Ala Leu Gln Arg Asp Ala Phe Gln Ala Lys Ser 
        115                 120                 125             
Thr Pro Trp Gln Glu Asp Ile Tyr Glu Lys Pro Met Asn Glu Leu Asp 
    130                 135                 140                 
Lys Val Val Glu Lys His Lys Glu Ser Tyr Arg Arg Ile Leu Gly Gln 
145                 150                 155                 160 
Leu Leu Val Ala Glu Lys Ser Arg Arg Gln Thr Ile Leu Glu Leu Glu 
                165                 170                 175     
Glu Glu Lys Arg Lys His Lys Glu Tyr Met Glu Lys Ser Asp Glu Phe 
            180                 185                 190         
Ile Cys Leu Leu Glu Gln Glu Cys Glu Arg Leu Lys Lys Leu Ile Asp 
        195                 200                 205             
Gln Glu Ile Lys Ser Gln Glu Glu Lys Glu Gln Glu Lys Glu Lys Arg 
    210                 215                 220                 
Val Thr Thr Leu Lys Glu Glu Leu Thr Lys Leu Lys Ser Phe Ala Leu 
225                 230                 235                 240 
Met Val Val Asp Glu Gln Gln Arg Leu Thr Ala Gln Leu Thr Leu Gln 
                245                 250                 255     
Arg Gln Lys Ile Gln Glu Leu Thr Thr Asn Ala Lys Glu Thr His Thr 
            260                 265                 270         
Lys Leu Ala Leu Ala Glu Ala Arg Val Gln Glu Glu Glu Gln Lys Ala 
        275                 280                 285             
Thr Arg Leu Glu Lys Glu Leu Gln Thr Gln Thr Thr Lys Phe His Gln 
    290                 295                 300                 
Asp Gln Asp Thr Ile Met Ala Lys Leu Thr Asn Glu Asp Ser Gln Asn 
305                 310                 315                 320 
Arg Gln Leu Gln Gln Lys Leu Ala Ala Leu Ser Arg Gln Ile Asp Glu 
                325                 330                 335     
Leu Glu Glu Thr Asn Arg Ser Leu Arg Lys Ala Glu Glu Glu Leu Gln 
            340                 345                 350         
Asp Ile Lys Glu Lys Ile Ser Lys Gly Glu Tyr Gly Asn Ala Gly Ile 
        355                 360                 365             
Met Ala Glu Val Glu Glu Leu Arg Lys Arg Val Leu Asp Met Glu Gly 
    370                 375                 380                 
Lys Asp Glu Glu Leu Ile Lys Met Glu Glu Gln Cys Arg Asp Leu Asn 
385                 390                 395                 400 
Lys Arg Leu Glu Arg Glu Thr Leu Gln Ser Lys Asp Phe Lys Leu Glu 
                405                 410                 415     
Val Glu Lys Leu Ser Lys Arg Ile Met Ala Leu Glu Lys Leu Glu Asp 
            420                 425                 430         
Ala Phe Asn Lys Ser Lys Gln Glu Cys Tyr Ser Leu Lys Cys Asn Leu 
        435                 440                 445             
Glu Lys Glu Arg Met Thr Thr Lys Gln Leu Ser Gln Glu Leu Glu Ser 
    450                 455                 460                 
Leu Lys Val Arg Ile Lys Glu Leu Glu Ala Ile Glu Ser Arg Leu Glu 
465                 470                 475                 480 
Lys Thr Glu Phe Thr Leu Lys Glu Asp Leu Thr Lys Leu Lys Thr Leu 
                485                 490                 495     
Thr Val Met Phe Val Asp Glu Arg Lys Thr Met Ser Glu Lys Leu Lys 
            500                 505                 510         
Lys Thr Glu Asp Lys Leu Gln Ala Ala Ser Ser Gln Leu Gln Val Glu 
        515                 520                 525             
Gln Asn Lys Val Thr Thr Val Thr Glu Lys Leu Ile Glu Glu Thr Lys 
    530                 535                 540                 
Arg Ala Leu Lys Ser Lys Thr Asp Val Glu Glu Lys Met Tyr Ser Val 
545                 550                 555                 560 
Thr Lys Glu Arg Asp Asp Leu Lys Asn Lys Leu Lys Ala Glu Glu Glu 
                565                 570                 575     
Lys Gly Asn Asp Leu Leu Ser Arg Val Asn Met Leu Lys Asn Arg Leu 
            580                 585                 590         
Gln Ser Leu Glu Ala Ile Glu Lys Asp Phe Leu Lys Asn Lys Leu Asn 
        595                 600                 605             
Gln Asp Ser Gly Lys Ser Thr Thr Ala Leu His Gln Glu Asn Asn Lys 
    610                 615                 620                 
Ile Lys Glu Leu Ser Gln Glu Val Glu Arg Leu Lys Leu Lys Leu Lys 
625                 630                 635                 640 
Asp Met Lys Ala Ile Glu Asp Asp Leu Met Lys Thr Glu Asp Glu Tyr 
                645                 650                 655     
Glu Thr Leu Glu Arg Arg Tyr Ala Asn Glu Arg Asp Lys Ala Gln Phe 
            660                 665                 670         
Leu Ser Lys Glu Leu Glu His Val Lys Met Glu Leu Ala Lys Tyr Lys 
        675                 680                 685             
Leu Ala Glu Lys Thr Glu Thr Ser His Glu Gln Trp Leu Phe Lys Arg 
    690                 695                 700                 
Leu Gln Glu Glu Glu Ala Lys Ser Gly His Leu Ser Arg Glu Val Asp 
705                 710                 715                 720 
Ala Leu Lys Glu Lys Ile His Glu Tyr Met Ala Thr Glu Asp Leu Ile 
                725                 730                 735     
Cys His Leu Gln Gly Asp His Ser Val Leu Gln Lys Lys Leu Asn Gln 
            740                 745                 750         
Gln Glu Asn Arg Asn Arg Asp Leu Gly Arg Glu Ile Glu Asn Leu Thr 
        755                 760                 765             
Lys Glu Leu Glu Arg Tyr Arg His Phe Ser Lys Ser Leu Arg Pro Ser 
    770                 775                 780                 
Leu Asn Gly Arg Arg Ile Ser Asp Pro Gln Val Phe Ser Lys Glu Val 
785                 790                 795                 800 
Gln Thr Glu Ala Val Asp Asn Glu Pro Pro Asp Tyr Lys Ser Leu Ile 
                805                 810                 815     
Pro Leu Glu Arg Ala Val Ile Asn Gly Gln Leu Tyr Glu Glu Ser Glu 
            820                 825                 830         
Asn Gln Asp Glu Asp Pro Asn Asp Glu Gly Ser Val Leu Ser Phe Lys 
        835                 840                 845             
Cys Ser Gln Ser Thr Pro Cys Pro Val Asn Arg Lys Leu Trp Ile Pro 
    850                 855                 860                 
Trp Met Lys Ser Lys Glu Gly His Leu Gln Asn Gly Lys Met Gln Thr 
865                 870                 875                 880 
Lys Pro Asn Ala Asn Phe Val Gln Pro Gly Asp Leu Val Leu Ser His 
                885                 890                 895     
Thr Pro Gly Gln Pro Leu His Ile Lys Val Thr Pro Asp His Val Gln 
            900                 905                 910         
Asn Thr Ala Thr Leu Glu Ile Thr Ser Pro Thr Thr Glu Ser Pro His 
        915                 920                 925             
Ser Tyr Thr Ser Thr Ala Val Ile Pro Asn Cys Gly Thr Pro Lys Gln 
    930                 935                 940                 
Arg Ile Thr Ile Leu Gln Asn Ala Ser Ile Thr Pro Val Lys Ser Lys 
945                 950                 955                 960 
Thr Ser Thr Glu Asp Leu Met Asn Leu Glu Gln Gly Met Ser Pro Ile 
                965                 970                 975     
Thr Met Ala Thr Phe Ala Arg Ala Gln Thr Pro Glu Ser Cys Gly Ser 
            980                 985                 990         
Leu Thr Pro Glu Arg Thr Met Ser Pro Ile Gln Val Leu Ala Val Thr 
        995                 1000                1005            
Gly Ser Ala Ser Ser Pro Glu Gln Gly Arg Ser Pro Glu Pro Thr Glu 
    1010                1015                1020                
Ile Ser Ala Lys His Ala Ile Phe Arg Val Ser Pro Asp Arg Gln Ser 
1025                1030                1035                1040
Ser Trp Gln Phe Gln Arg Ser Asn Ser Asn Ser Ser Ser Val Ile Thr 
                1045                1050                1055    
Thr Glu Asp Asn Lys Ile His Ile His Leu Gly Ser Pro Tyr Met Gln 
            1060                1065                1070        
Ala Val Ala Ser Pro Val Arg Pro Ala Ser Pro Ser Ala Pro Leu Gln 
        1075                1080                1085            
Asp Asn Arg Thr Gln Gly Leu Ile Asn Gly Ala Leu Asn Lys Thr Thr 
    1090                1095                1100                
Asn Lys Val Thr Ser Ser Ile Thr Ile Thr Pro Thr Ala Thr Pro Leu 
1105                1110                1115                1120
Pro Arg Gln Ser Gln Ile Thr Val Ser Asn Ile Tyr Asn 
                1125                1130            

<210> 139
<211> 4653
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..4653
<223> /mol_type="unassigned DNA"
      /note="MGLL (monoglyceride lipase)"
      /organism="Homo sapiens"

<400> 139
cccaaaccaa cttgtcccca tcaactccat ctttctagtc cccaccttcc ccggtgcaga       60

cacccggcga agcccacccg gttttcccag cggcatttcc gatgacagct tcggggctac      120

gtgtcctgtg ctgtcggaga cgcacaggaa gcaaagtttg tgagaagcct tgggggcgac      180

tttgccttgg gcacccgcat ttgtgcgtct gcgaggtgcc tcggtgtgcg cggagctagt      240

ttcccagttt cccgggcccc tcccttctcc gagcccctct agcgatttgt ttaggaaaag      300

tgatgacatg aactagtagt ggagaatcgc agcgccgctc cccgccctgg ggagggaggg      360

gagccccgga gagcctgccg gtgggagctg gaagcaggct cccggctgag cgccccagcc      420

cgaaaggcag ggtctgggtg cgggaagagg gctcggagct gccttcctgc tgccttgggg      480

ccgcccagat gagggaacag cccgatttgc ctggttctga ttctccaggc tgtcgtggtt      540

gtggaatgca aacgccagca cataatggaa acaggacctg aagacccttc cagcatgcca      600

gaggaaagtt cccccaggcg gaccccgcag agcattccct accaggacct ccctcacctg      660

gtcaatgcag acggacagta cctcttctgc aggtactgga aacccacagg cacacccaag      720

gccctcatct ttgtgtccca tggagccgga gagcacagtg gccgctatga agagctggct      780

cggatgctga tggggctgga cctgctggtg ttcgcccacg accatgttgg ccacggacag      840

agcgaagggg agaggatggt agtgtctgac ttccacgttt tcgtcaggga tgtgttgcag      900

catgtggatt ccatgcagaa agactaccct gggcttcctg tcttccttct gggccactcc      960

atgggaggcg ccatcgccat cctcacggcc gcagagaggc cgggccactt cgccggcatg     1020

gtactcattt cgcctctggt tcttgccaat cctgaatctg caacaacttt caaggtcctt     1080

gctgcgaaag tgctcaacct tgtgctgcca aacttgtccc tcgggcccat cgactccagc     1140

gtgctctctc ggaataagac agaggtcgac atttataact cagaccccct gatctgccgg     1200

gcagggctga aggtgtgctt cggcatccaa ctgctgaatg ccgtctcacg ggtggagcgc     1260

gccctcccca agctgactgt gcccttcctg ctgctccagg gctctgccga tcgcctatgt     1320

gacagcaaag gggcctacct gctcatggag ttagccaaga gccaggacaa gactctcaag     1380

atttatgaag gtgcctacca tgttctccac aaggagcttc ctgaagtcac caactccgtc     1440

ttccatgaaa taaacatgtg ggtctctcaa aggacagcca cggcaggaac tgcgtcccca     1500

ccctgaatgc attggccggt gcccggctca tggtctgggg gatgcaggca ggggaagggc     1560

agagatggct tctcagatat ggcttgccaa aaaaaaaaaa aaaaaaaaat cagaaattgg     1620

agaaatcctt agcacaattt tctaaaaaat aacagacatt tttgttatac attagactat     1680

cagacactgg acctacctta atggttagac actttatgca aaaaaagaga aaggtcccag     1740

gtgattttcc acaaagaatg tgctaaaatg tccactgaaa acaaagccaa gcctctgccc     1800

tgcctctccc agctcccaca agggttccag gaattcctgg tgttcccagg acaccagact     1860

gcaataactg gaggcgcctc cttcctgccc acccttcgct cacgccccag cgccctctct     1920

gaccagcctc cgcttggtgg ccttcctctg gccgtgtgat gaggtggttg ctgtctccat     1980

aggggccagc tccccagggc agactcacgt gcccctctga ggctcagaaa atgcccagcc     2040

cttcctcaaa atgagcagcc acccatgact ttgtgggctc cttgttagcc tgagaccagg     2100

ctttgcagag gggcgggggg tgaggcttag cccagaagga gaactgagca ggaaaccaag     2160

gctcttctct gtcccctgcc cttcccctcc tgccaggggg aggctcaggt tggtccccga     2220

gtgccgcctg tactcacaaa ggctgccttt cctctagagt cactaatttt acctgatgct     2280

atgagagaat catattgaag atgaaatgtc taatatataa tgtatatttt aaagcagaga     2340

ctattttggt ggataggtgg gagggagcaa ggggagtttg agggaatcag agcttgatgc     2400

tactgtacag aactggacag gttgggccgg cagtggtggg gccagagggc tctgtgctct     2460

aggagctaag ccagcagccc ccgagagggg acttggctgg gcctttccta tgggcaaggc     2520

ccagtgctct tcctgcccac cagggaccat ggagcagtgg caccctatgg ggctatgatc     2580

cctaggcctg ggcctgggcc tgcctatggc ccagagctac cctgggagtg tcagtgctag     2640

cagcacagct acctctggtg gcaggagaag agaggcccag cacagcagca ggccaggcct     2700

tcctgtccag gtctgcatgg agcactcggt gacccagagc agggactgga ggcaccccca     2760

gccctgcccc aggccacagc aggacaggcc gggacaggcc tcacccaagg ccaaggctgg     2820

catcagccaa tcattcagag ctgaggccct gggcctagcc tgcccttctc aggtgccaat     2880

accaccccag ccctgccctt ggcctcactt tttcccagca ataagtgggg ttcaccaccc     2940

gcctcgggaa tactttcccc ttctaaatgg gacttgctgt tacctcagga ggctccttag     3000

tgcaaatatg accctggtca gggctttgcc accgttgaag ccctgcagaa ggtgcaatgt     3060

aggggttctg gggccacaga ggagaggcca cttcccacca ggacccccaa catgaagtct     3120

aggcctcagg ggctcccgcc cttcttcctc cagcagcggg aactgccact gctctcccag     3180

gccctgttct ggaggctaac cttggttcct ggagagtgtg cccctccacc ctccctccag     3240

cagccctgat cacaccatga gagccaggaa cgggtcaccc tgctgaagat cactctgtgc     3300

cctgggggag gagccaagcc ctcaccccac aaggggcagg tgggggcttg gttgctgacc     3360

cggcccaagt ccccacagag caccttctgt agctccagct tgtctccctg gcttctcttt     3420

gaaggagaaa aatgtaaaat atgcactgag aaagccagcc ccgcctgctt agtcagcccc     3480

ggcagcaggg cagccatggg aactcaggaa aagcaggaac cctttccaaa agcccagaga     3540

tgccctgggc tcagatctgt aattctccca ggagctgtga tagagcaggc cacacaaagt     3600

ccctacgcct ccctgctgcc tcccccagat gcatgtggtg gcatcaccat tccccaaatt     3660

gaatatcagc atgcggcctg accagggact ctttagatgc atgaatttat ttatatgaag     3720

gctctcacag agacacacac agcacttcag tagcatttgc attcctggtt aaagaatcac     3780

caatatttaa aataaaaact ttcctgaaat tgggactgtc atgttatcca gaagggctgg     3840

tacatccgcc caccatgtcc ccctgctggg tcaggagcca acacaggacc ctgcgtgtga     3900

gcgtgcctga catctcacgc acggccactc cagagccggt ccctgtcctt ggaaagctgt     3960

gaagccttgc gttgagttcc ttctcgatac tgacggctcc gtgctgacat tctgagctct     4020

ggagtcacac cagcgcaggg gcgtggagga actgaggttt ggaaggaatg ccaggtctcg     4080

cacagcttgg cctcgagaag gtgagaggaa ggcaaaggcc agggagggga cccagagagg     4140

cctggcacac aaggcccaag caccaccgtc aacacagccc agtccataca gaaatgggtt     4200

tcatgcctga aaagcttttt acagaaagat gccgcctgta gccagtgaca gccgcaaccc     4260

tacaggcctc agttccttgc agaggtgagg ggtagagagt cagcctccct cccttccagc     4320

agcgacccag cttccctcca cttccaggtg gtgctgggct caccgaggga gcactggtgg     4380

gtgctctgaa aacccacagg atcccacctc caggcccacc tgggtcccat ctcactctct     4440

tcttctttca ccaattgcta acatagacct tgttgggatc acgatggctt cacaagccag     4500

ctgttgggtt tgctatgtca ctgtggctca gtcacatccc tgcgtgtata ctgtctgcgg     4560

ggcacatatg tatccattta gagctaaagg aatcagtgta cactacagct aatcctaata     4620

aatccgatgt tttcggaatg gcaaaaaaaa aaa                                  4653


<210> 140
<211> 4246
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..4246
<223> /mol_type="unassigned DNA"
      /note="MGLL (monoglyceride lipase)"
      /organism="Homo sapiens"

<400> 140
acctcgggcc gcccccgccg ccgagccggc ccagggataa agtggcggcg cagacgccgc       60

accctgtcgc cgcgaagccg gtcgcgcgca gctcgtcccg gccctggccc gccgcaaacg      120

aggatccgct gcgctcgggg aacgcgacag cggcgctcgt ggccccggac ctgaagaccc      180

ttccagcatg ccagaggaaa gttcccccag gcggaccccg cagagcattc cctaccagga      240

cctccctcac ctggtcaatg cagacggaca gtacctcttc tgcaggtact ggaaacccac      300

aggcacaccc aaggccctca tctttgtgtc ccatggagcc ggagagcaca gtggccgcta      360

tgaagagctg gctcggatgc tgatggggct ggacctgctg gtgttcgccc acgaccatgt      420

tggccacgga cagagcgaag gggagaggat ggtagtgtct gacttccacg ttttcgtcag      480

ggatgtgttg cagcatgtgg attccatgca gaaagactac cctgggcttc ctgtcttcct      540

tctgggccac tccatgggag gcgccatcgc catcctcacg gccgcagaga ggccgggcca      600

cttcgccggc atggtactca tttcgcctct ggttcttgcc aatcctgaat ctgcaacaac      660

tttcaaggtc cttgctgcga aagtgctcaa ccttgtgctg ccaaacttgt ccctcgggcc      720

catcgactcc agcgtgctct ctcggaataa gacagaggtc gacatttata actcagaccc      780

cctgatctgc cgggcagggc tgaaggtgtg cttcggcatc caactgctga atgccgtctc      840

acgggtggag cgcgccctcc ccaagctgac tgtgcccttc ctgctgctcc agggctctgc      900

cgatcgccta tgtgacagca aaggggccta cctgctcatg gagttagcca agagccagga      960

caagactctc aagatttatg aaggtgccta ccatgttctc cacaaggagc ttcctgaagt     1020

caccaactcc gtcttccatg aaataaacat gtgggtctct caaaggacag ccacggcagg     1080

aactgcgtcc ccaccctgaa tgcattggcc ggtgcccggc tcatggtctg ggggatgcag     1140

gcaggggaag ggcagagatg gcttctcaga tatggcttgc caaaaaaaaa aaaaaaaaaa     1200

aatcagaaat tggagaaatc cttagcacaa ttttctaaaa aataacagac atttttgtta     1260

tacattagac tatcagacac tggacctacc ttaatggtta gacactttat gcaaaaaaag     1320

agaaaggtcc caggtgattt tccacaaaga atgtgctaaa atgtccactg aaaacaaagc     1380

caagcctctg ccctgcctct cccagctccc acaagggttc caggaattcc tggtgttccc     1440

aggacaccag actgcaataa ctggaggcgc ctccttcctg cccacccttc gctcacgccc     1500

cagcgccctc tctgaccagc ctccgcttgg tggccttcct ctggccgtgt gatgaggtgg     1560

ttgctgtctc cataggggcc agctccccag ggcagactca cgtgcccctc tgaggctcag     1620

aaaatgccca gcccttcctc aaaatgagca gccacccatg actttgtggg ctccttgtta     1680

gcctgagacc aggctttgca gaggggcggg gggtgaggct tagcccagaa ggagaactga     1740

gcaggaaacc aaggctcttc tctgtcccct gcccttcccc tcctgccagg gggaggctca     1800

ggttggtccc cgagtgccgc ctgtactcac aaaggctgcc tttcctctag agtcactaat     1860

tttacctgat gctatgagag aatcatattg aagatgaaat gtctaatata taatgtatat     1920

tttaaagcag agactatttt ggtggatagg tgggagggag caaggggagt ttgagggaat     1980

cagagcttga tgctactgta cagaactgga caggttgggc cggcagtggt ggggccagag     2040

ggctctgtgc tctaggagct aagccagcag cccccgagag gggacttggc tgggcctttc     2100

ctatgggcaa ggcccagtgc tcttcctgcc caccagggac catggagcag tggcacccta     2160

tggggctatg atccctaggc ctgggcctgg gcctgcctat ggcccagagc taccctggga     2220

gtgtcagtgc tagcagcaca gctacctctg gtggcaggag aagagaggcc cagcacagca     2280

gcaggccagg ccttcctgtc caggtctgca tggagcactc ggtgacccag agcagggact     2340

ggaggcaccc ccagccctgc cccaggccac agcaggacag gccgggacag gcctcaccca     2400

aggccaaggc tggcatcagc caatcattca gagctgaggc cctgggccta gcctgccctt     2460

ctcaggtgcc aataccaccc cagccctgcc cttggcctca ctttttccca gcaataagtg     2520

gggttcacca cccgcctcgg gaatactttc cccttctaaa tgggacttgc tgttacctca     2580

ggaggctcct tagtgcaaat atgaccctgg tcagggcttt gccaccgttg aagccctgca     2640

gaaggtgcaa tgtaggggtt ctggggccac agaggagagg ccacttccca ccaggacccc     2700

caacatgaag tctaggcctc aggggctccc gcccttcttc ctccagcagc gggaactgcc     2760

actgctctcc caggccctgt tctggaggct aaccttggtt cctggagagt gtgcccctcc     2820

accctccctc cagcagccct gatcacacca tgagagccag gaacgggtca ccctgctgaa     2880

gatcactctg tgccctgggg gaggagccaa gccctcaccc cacaaggggc aggtgggggc     2940

ttggttgctg acccggccca agtccccaca gagcaccttc tgtagctcca gcttgtctcc     3000

ctggcttctc tttgaaggag aaaaatgtaa aatatgcact gagaaagcca gccccgcctg     3060

cttagtcagc cccggcagca gggcagccat gggaactcag gaaaagcagg aaccctttcc     3120

aaaagcccag agatgccctg ggctcagatc tgtaattctc ccaggagctg tgatagagca     3180

ggccacacaa agtccctacg cctccctgct gcctccccca gatgcatgtg gtggcatcac     3240

cattccccaa attgaatatc agcatgcggc ctgaccaggg actctttaga tgcatgaatt     3300

tatttatatg aaggctctca cagagacaca cacagcactt cagtagcatt tgcattcctg     3360

gttaaagaat caccaatatt taaaataaaa actttcctga aattgggact gtcatgttat     3420

ccagaagggc tggtacatcc gcccaccatg tccccctgct gggtcaggag ccaacacagg     3480

accctgcgtg tgagcgtgcc tgacatctca cgcacggcca ctccagagcc ggtccctgtc     3540

cttggaaagc tgtgaagcct tgcgttgagt tccttctcga tactgacggc tccgtgctga     3600

cattctgagc tctggagtca caccagcgca ggggcgtgga ggaactgagg tttggaagga     3660

atgccaggtc tcgcacagct tggcctcgag aaggtgagag gaaggcaaag gccagggagg     3720

ggacccagag aggcctggca cacaaggccc aagcaccacc gtcaacacag cccagtccat     3780

acagaaatgg gtttcatgcc tgaaaagctt tttacagaaa gatgccgcct gtagccagtg     3840

acagccgcaa ccctacaggc ctcagttcct tgcagaggtg aggggtagag agtcagcctc     3900

cctcccttcc agcagcgacc cagcttccct ccacttccag gtggtgctgg gctcaccgag     3960

ggagcactgg tgggtgctct gaaaacccac aggatcccac ctccaggccc acctgggtcc     4020

catctcactc tcttcttctt tcaccaattg ctaacataga ccttgttggg atcacgatgg     4080

cttcacaagc cagctgttgg gtttgctatg tcactgtggc tcagtcacat ccctgcgtgt     4140

atactgtctg cggggcacat atgtatccat ttagagctaa aggaatcagt gtacactaca     4200

gctaatccta ataaatccga tgttttcgga atggcaaaaa aaaaaa                    4246


<210> 141
<211> 4563
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..4563
<223> /mol_type="unassigned DNA"
      /note="MGLL (monoglyceride lipase)"
      /organism="Homo sapiens"

<400> 141
cccaaaccaa cttgtcccca tcaactccat ctttctagtc cccaccttcc ccggtgcaga       60

cacccggcga agcccacccg gttttcccag cggcatttcc gatgacagct tcggggctac      120

gtgtcctgtg ctgtcggaga cgcacaggaa gcaaagtttg tgagaagcct tgggggcgac      180

tttgccttgg gcacccgcat ttgtgcgtct gcgaggtgcc tcggtgtgcg cggagctagt      240

ttcccagttt cccgggcccc tcccttctcc gagcccctct agcgatttgt ttaggaaaag      300

tgatgacatg aactagtagt ggagaatcgc agcgccgctc cccgccctgg ggagggaggg      360

gagccccgga gagcctgccg gtgggagctg gaagcaggct cccggctgag cgccccagcc      420

cgaaaggcag ggtctgggtg cgggaagagg gctcggagct gccttcctgc tgccttgggg      480

ccgcccagat gagggaacag cccgatttgc ctggttctga ttctccaggc tgtcgtggtt      540

gtggaatgca aacgccagca cataatggaa acaggacctg aagacccttc cagcatgcca      600

gaggaaagtt cccccaggcg gaccccgcag agcattccct accaggacct ccctcacctg      660

gtcaatgcag acggacagta cctcttctgc aggtactgga aacccacagg cacacccaag      720

gccctcatct ttgtgtccca tggagccgga gagcacagtg gccgctatga agagctggct      780

cggatgctga tggggctgga cctgctggtg ttcgcccacg accatgttgg ccacggacag      840

agcgaagggg agaggatggt agtgtctgac ttccacgttt tcgtcaggga tgtgttgcag      900

catgtggatt ccatgcagaa agactaccct gggcttcctg tcttccttct gggccactcc      960

atgggaggcg ccatcgccat cctcacggcc gcagagaggc cgggccactt cgccggcatg     1020

gtactcattt cgcctctggt tcttgccaat cctgaatctg caacaacttt caaggtcgac     1080

atttataact cagaccccct gatctgccgg gcagggctga aggtgtgctt cggcatccaa     1140

ctgctgaatg ccgtctcacg ggtggagcgc gccctcccca agctgactgt gcccttcctg     1200

ctgctccagg gctctgccga tcgcctatgt gacagcaaag gggcctacct gctcatggag     1260

ttagccaaga gccaggacaa gactctcaag atttatgaag gtgcctacca tgttctccac     1320

aaggagcttc ctgaagtcac caactccgtc ttccatgaaa taaacatgtg ggtctctcaa     1380

aggacagcca cggcaggaac tgcgtcccca ccctgaatgc attggccggt gcccggctca     1440

tggtctgggg gatgcaggca ggggaagggc agagatggct tctcagatat ggcttgccaa     1500

aaaaaaaaaa aaaaaaaaat cagaaattgg agaaatcctt agcacaattt tctaaaaaat     1560

aacagacatt tttgttatac attagactat cagacactgg acctacctta atggttagac     1620

actttatgca aaaaaagaga aaggtcccag gtgattttcc acaaagaatg tgctaaaatg     1680

tccactgaaa acaaagccaa gcctctgccc tgcctctccc agctcccaca agggttccag     1740

gaattcctgg tgttcccagg acaccagact gcaataactg gaggcgcctc cttcctgccc     1800

acccttcgct cacgccccag cgccctctct gaccagcctc cgcttggtgg ccttcctctg     1860

gccgtgtgat gaggtggttg ctgtctccat aggggccagc tccccagggc agactcacgt     1920

gcccctctga ggctcagaaa atgcccagcc cttcctcaaa atgagcagcc acccatgact     1980

ttgtgggctc cttgttagcc tgagaccagg ctttgcagag gggcgggggg tgaggcttag     2040

cccagaagga gaactgagca ggaaaccaag gctcttctct gtcccctgcc cttcccctcc     2100

tgccaggggg aggctcaggt tggtccccga gtgccgcctg tactcacaaa ggctgccttt     2160

cctctagagt cactaatttt acctgatgct atgagagaat catattgaag atgaaatgtc     2220

taatatataa tgtatatttt aaagcagaga ctattttggt ggataggtgg gagggagcaa     2280

ggggagtttg agggaatcag agcttgatgc tactgtacag aactggacag gttgggccgg     2340

cagtggtggg gccagagggc tctgtgctct aggagctaag ccagcagccc ccgagagggg     2400

acttggctgg gcctttccta tgggcaaggc ccagtgctct tcctgcccac cagggaccat     2460

ggagcagtgg caccctatgg ggctatgatc cctaggcctg ggcctgggcc tgcctatggc     2520

ccagagctac cctgggagtg tcagtgctag cagcacagct acctctggtg gcaggagaag     2580

agaggcccag cacagcagca ggccaggcct tcctgtccag gtctgcatgg agcactcggt     2640

gacccagagc agggactgga ggcaccccca gccctgcccc aggccacagc aggacaggcc     2700

gggacaggcc tcacccaagg ccaaggctgg catcagccaa tcattcagag ctgaggccct     2760

gggcctagcc tgcccttctc aggtgccaat accaccccag ccctgccctt ggcctcactt     2820

tttcccagca ataagtgggg ttcaccaccc gcctcgggaa tactttcccc ttctaaatgg     2880

gacttgctgt tacctcagga ggctccttag tgcaaatatg accctggtca gggctttgcc     2940

accgttgaag ccctgcagaa ggtgcaatgt aggggttctg gggccacaga ggagaggcca     3000

cttcccacca ggacccccaa catgaagtct aggcctcagg ggctcccgcc cttcttcctc     3060

cagcagcggg aactgccact gctctcccag gccctgttct ggaggctaac cttggttcct     3120

ggagagtgtg cccctccacc ctccctccag cagccctgat cacaccatga gagccaggaa     3180

cgggtcaccc tgctgaagat cactctgtgc cctgggggag gagccaagcc ctcaccccac     3240

aaggggcagg tgggggcttg gttgctgacc cggcccaagt ccccacagag caccttctgt     3300

agctccagct tgtctccctg gcttctcttt gaaggagaaa aatgtaaaat atgcactgag     3360

aaagccagcc ccgcctgctt agtcagcccc ggcagcaggg cagccatggg aactcaggaa     3420

aagcaggaac cctttccaaa agcccagaga tgccctgggc tcagatctgt aattctccca     3480

ggagctgtga tagagcaggc cacacaaagt ccctacgcct ccctgctgcc tcccccagat     3540

gcatgtggtg gcatcaccat tccccaaatt gaatatcagc atgcggcctg accagggact     3600

ctttagatgc atgaatttat ttatatgaag gctctcacag agacacacac agcacttcag     3660

tagcatttgc attcctggtt aaagaatcac caatatttaa aataaaaact ttcctgaaat     3720

tgggactgtc atgttatcca gaagggctgg tacatccgcc caccatgtcc ccctgctggg     3780

tcaggagcca acacaggacc ctgcgtgtga gcgtgcctga catctcacgc acggccactc     3840

cagagccggt ccctgtcctt ggaaagctgt gaagccttgc gttgagttcc ttctcgatac     3900

tgacggctcc gtgctgacat tctgagctct ggagtcacac cagcgcaggg gcgtggagga     3960

actgaggttt ggaaggaatg ccaggtctcg cacagcttgg cctcgagaag gtgagaggaa     4020

ggcaaaggcc agggagggga cccagagagg cctggcacac aaggcccaag caccaccgtc     4080

aacacagccc agtccataca gaaatgggtt tcatgcctga aaagcttttt acagaaagat     4140

gccgcctgta gccagtgaca gccgcaaccc tacaggcctc agttccttgc agaggtgagg     4200

ggtagagagt cagcctccct cccttccagc agcgacccag cttccctcca cttccaggtg     4260

gtgctgggct caccgaggga gcactggtgg gtgctctgaa aacccacagg atcccacctc     4320

caggcccacc tgggtcccat ctcactctct tcttctttca ccaattgcta acatagacct     4380

tgttgggatc acgatggctt cacaagccag ctgttgggtt tgctatgtca ctgtggctca     4440

gtcacatccc tgcgtgtata ctgtctgcgg ggcacatatg tatccattta gagctaaagg     4500

aatcagtgta cactacagct aatcctaata aatccgatgt tttcggaatg gcaaaaaaaa     4560

aaa                                                                   4563


<210> 142
<211> 313
<212> PRT
<213> Homo sapiens

<220> 
<223> MGLL (monoglyceride lipase)

<400> 142
Met Glu Thr Gly Pro Glu Asp Pro Ser Ser Met Pro Glu Glu Ser Ser 
1               5                   10                  15      
Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr Gln Asp Leu Pro His Leu 
            20                  25                  30          
Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys Arg Tyr Trp Lys Pro Thr 
        35                  40                  45              
Gly Thr Pro Lys Ala Leu Ile Phe Val Ser His Gly Ala Gly Glu His 
    50                  55                  60                  
Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met Leu Met Gly Leu Asp Leu 
65                  70                  75                  80  
Leu Val Phe Ala His Asp His Val Gly His Gly Gln Ser Glu Gly Glu 
                85                  90                  95      
Arg Met Val Val Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln 
            100                 105                 110         
His Val Asp Ser Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu 
        115                 120                 125             
Leu Gly His Ser Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu 
    130                 135                 140                 
Arg Pro Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu 
145                 150                 155                 160 
Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys Val Leu Ala Ala Lys Val 
                165                 170                 175     
Leu Asn Leu Val Leu Pro Asn Leu Ser Leu Gly Pro Ile Asp Ser Ser 
            180                 185                 190         
Val Leu Ser Arg Asn Lys Thr Glu Val Asp Ile Tyr Asn Ser Asp Pro 
        195                 200                 205             
Leu Ile Cys Arg Ala Gly Leu Lys Val Cys Phe Gly Ile Gln Leu Leu 
    210                 215                 220                 
Asn Ala Val Ser Arg Val Glu Arg Ala Leu Pro Lys Leu Thr Val Pro 
225                 230                 235                 240 
Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser Lys Gly 
                245                 250                 255     
Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys 
            260                 265                 270         
Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro Glu Val 
        275                 280                 285             
Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln Arg Thr 
    290                 295                 300                 
Ala Thr Ala Gly Thr Ala Ser Pro Pro 
305                 310             

<210> 143
<211> 303
<212> PRT
<213> Homo sapiens

<220> 
<223> MGLL (monoglyceride lipase)

<400> 143
Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr 
1               5                   10                  15      
Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys 
            20                  25                  30          
Arg Tyr Trp Lys Pro Thr Gly Thr Pro Lys Ala Leu Ile Phe Val Ser 
        35                  40                  45              
His Gly Ala Gly Glu His Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met 
    50                  55                  60                  
Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His Val Gly His 
65                  70                  75                  80  
Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe His Val Phe 
                85                  90                  95      
Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln Lys Asp Tyr Pro 
            100                 105                 110         
Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly Gly Ala Ile Ala 
        115                 120                 125             
Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala Gly Met Val Leu 
    130                 135                 140                 
Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys 
145                 150                 155                 160 
Val Leu Ala Ala Lys Val Leu Asn Leu Val Leu Pro Asn Leu Ser Leu 
                165                 170                 175     
Gly Pro Ile Asp Ser Ser Val Leu Ser Arg Asn Lys Thr Glu Val Asp 
            180                 185                 190         
Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys Val Cys 
        195                 200                 205             
Phe Gly Ile Gln Leu Leu Asn Ala Val Ser Arg Val Glu Arg Ala Leu 
    210                 215                 220                 
Pro Lys Leu Thr Val Pro Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg 
225                 230                 235                 240 
Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser 
                245                 250                 255     
Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly Ala Tyr His Val Leu His 
            260                 265                 270         
Lys Glu Leu Pro Glu Val Thr Asn Ser Val Phe His Glu Ile Asn Met 
        275                 280                 285             
Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro Pro 
    290                 295                 300             

<210> 144
<211> 283
<212> PRT
<213> Homo sapiens

<220> 
<223> MGLL (monoglyceride lipase)

<400> 144
Met Glu Thr Gly Pro Glu Asp Pro Ser Ser Met Pro Glu Glu Ser Ser 
1               5                   10                  15      
Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr Gln Asp Leu Pro His Leu 
            20                  25                  30          
Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys Arg Tyr Trp Lys Pro Thr 
        35                  40                  45              
Gly Thr Pro Lys Ala Leu Ile Phe Val Ser His Gly Ala Gly Glu His 
    50                  55                  60                  
Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met Leu Met Gly Leu Asp Leu 
65                  70                  75                  80  
Leu Val Phe Ala His Asp His Val Gly His Gly Gln Ser Glu Gly Glu 
                85                  90                  95      
Arg Met Val Val Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln 
            100                 105                 110         
His Val Asp Ser Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu 
        115                 120                 125             
Leu Gly His Ser Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu 
    130                 135                 140                 
Arg Pro Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu 
145                 150                 155                 160 
Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys Val Asp Ile Tyr Asn Ser 
                165                 170                 175     
Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys Val Cys Phe Gly Ile Gln 
            180                 185                 190         
Leu Leu Asn Ala Val Ser Arg Val Glu Arg Ala Leu Pro Lys Leu Thr 
        195                 200                 205             
Val Pro Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser 
    210                 215                 220                 
Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser Gln Asp Lys Thr 
225                 230                 235                 240 
Leu Lys Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro 
                245                 250                 255     
Glu Val Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln 
            260                 265                 270         
Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro Pro 
        275                 280             

<210> 145
<211> 5556
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..5556
<223> /mol_type="unassigned DNA"
      /note="OSMR (oncostatin M receptor)"
      /organism="Homo sapiens"

<400> 145
gcgcttgccc cgcagctgat tcatagcccc ggcccgggcc gcctctgcac gtccgccccg       60

gagcccgcac ccgcgcccca cgcgccgccg aggactcggc ccggctcgtg gagcccttcg      120

cccgcggcgt gagtaccccc gacccgcccg tccccgctct gctcgcgccc tgccgctgcg      180

ccgccctcgg tggcttttcc gacgggcgag ccccgtgctg tgcgggaaag aatccgacaa      240

cttcgcagcc catcccggct ggacgcgacc gggagtgcag cagcccgttc ccctcctcgg      300

tgccgcctct gcccagcgtt tgcttggctg ggctaccacc tgcgctcgga cggcgctcgg      360

agggtcctcg cccccggcct gcctacctga aaaccagaac tgatggctct atttgcagtc      420

tttcagacaa cattcttctt aacattgctg tccttgagga cttaccagag tgaagtcttg      480

gctgaacgtt taccattgac tcctgtatca cttaaagttt ccaccaattc tacgcgtcag      540

agtttgcact tacaatggac tgtccacaac cttccttatc atcaggaatt gaaaatggta      600

tttcagatcc agatcagtag gattgaaaca tccaatgtca tctgggtggg gaattacagc      660

accactgtga agtggaacca ggttctgcat tggagctggg aatctgagct ccctttggaa      720

tgtgccacac actttgtaag aataaagagt ttggtggacg atgccaagtt ccctgagcca      780

aatttctgga gcaactggag ttcctgggag gaagtcagtg tacaagattc tactggacag      840

gatatattgt tcgttttccc taaagataag ctggtggaag aaggcaccaa tgttaccatt      900

tgttacgttt ctaggaacat tcaaaataat gtatcctgtt atttggaagg gaaacagatt      960

catggagaac aacttgatcc acatgtaact gcattcaact tgaatagtgt gcctttcatt     1020

aggaataaag ggacaaatat ctattgtgag gcaagtcaag gaaatgtcag tgaaggcatg     1080

aaaggcatcg ttctttttgt ctcaaaagta cttgaggagc ccaaggactt ttcttgtgaa     1140

accgaggact tcaagacttt gcactgtact tgggatcctg ggacggacac tgccttgggg     1200

tggtctaaac aaccttccca aagctacact ttatttgaat cattttctgg ggaaaagaaa     1260

ctttgtacac acaaaaactg gtgtaattgg caaataactc aagactcaca agaaacctat     1320

aacttcacac tcatagctga aaattactta aggaagagaa gtgtcaatat cctttttaac     1380

ctgactcatc gagtttattt aatgaatcct tttagtgtca actttgaaaa tgtaaatgcc     1440

acaaatgcca tcatgacctg gaaggtgcac tccataagga ataatttcac atatttgtgt     1500

cagattgaac tccatggtga aggaaaaatg atgcaataca atgtttccat caaggtgaac     1560

ggtgagtact tcttaagtga actggaacct gccacagagt acatggcgcg agtacggtgt     1620

gctgatgcca gccacttctg gaaatggagt gaatggagtg gtcagaactt caccacactt     1680

gaagctgctc cctcagaggc ccctgatgtc tggagaattg tgagcttgga gccaggaaat     1740

catactgtga ccttattctg gaagccatta tcaaaactgc atgccaatgg aaagatcctg     1800

ttctataatg tagttgtaga aaacctagac aaaccatcca gttcagagct ccattccatt     1860

ccagcaccag ccaacagcac aaaactaatc cttgacaggt gttcctacca aatctgcgtc     1920

atagccaaca acagtgtggg tgcttctcct gcttctgtaa tagtcatctc tgcagacccc     1980

gaaaacaaag aggttgagga agaaagaatt gcaggcacag agggtggatt ctctctgtct     2040

tggaaacccc aacctggaga tgttataggc tatgttgtgg actggtgtga ccatacccag     2100

gatgtgctcg gtgatttcca gtggaagaat gtaggtccca ataccacaag cacagtcatt     2160

agcacagatg cttttaggcc aggagttcga tatgacttca gaatttatgg gttatctaca     2220

aaaaggattg cttgtttatt agagaaaaaa acaggatact ctcaggaact tgctccttca     2280

gacaaccctc acgtgctggt ggatacattg acatcccact ccttcactct gagttggaaa     2340

gattactcta ctgaatctca acctggtttt atacaagggt accatgtcta tctgaaatcc     2400

aaggcgaggc agtgccaccc acgatttgaa aaggcagttc tttcagatgg ttcagaatgt     2460

tgcaaataca aaattgacaa cccggaagaa aaggcattga ttgtggacaa cctaaagcca     2520

gaatccttct atgagttttt catcactcca ttcactagtg ctggtgaagg ccccagtgct     2580

acgttcacga aggtcacgac tccggatgaa cactcctcga tgctgattca tatcctactg     2640

cccatggttt tctgcgtctt gctcatcatg gtcatgtgct acttgaaaag tcagtggatc     2700

aaggagacct gttatcctga catccctgac ccttacaaga gcagcatcct gtcattaata     2760

aaattcaagg agaaccctca cctaataata atgaatgtca gtgactgtat cccagatgct     2820

attgaagttg taagcaagcc agaagggaca aagatacagt tcctaggcac taggaagtca     2880

ctcacagaaa ccgagttgac taagcctaac tacctttatc tccttccaac agaaaagaat     2940

cactctggcc ctggcccctg catctgtttt gagaacttga cctataacca ggcagcttct     3000

gactctggct cttgtggcca tgttccagta tccccaaaag ccccaagtat gctgggacta     3060

atgacctcac ctgaaaatgt actaaaggca ctagaaaaaa actacatgaa ctccctggga     3120

gaaatcccag ctggagaaac aagtttgaat tatgtgtccc agttggcttc acccatgttt     3180

ggagacaagg acagtctccc aacaaaccca gtagaggcac cacactgttc agagtataaa     3240

atgcaaatgg cagtctccct gcgtcttgcc ttgcctcccc cgaccgagaa tagcagcctc     3300

tcctcaatta cccttttaga tccaggtgaa cactactgct aaccagcatg ccgatttcat     3360

accttatgct acacagacat taagaagagc agagctggca ccctgtcatc accagtggcc     3420

ttggtcctta atcccagtac gatttgcagg tctggtttat ataagaccac tacagtctgg     3480

ctaggttaaa ggccagaggc tatggaactt aacactcccc attggagcaa gcttgcccta     3540

gagacggcag gatcatggga gcatgcttac cttctgctgt ttgttccagg ctcaccttta     3600

gaacaggaga cttgagcttg acctaaggat atgcattaac cactctacag actcccactc     3660

agtactgtac agggtggctg tggtcctaga agttcagttt ttactgagga aatatttcca     3720

ttaacagcaa ttattatatt gaaggcttta ataaaggcca caggagacat tactatagca     3780

tagattgtca aatgtaaatt tactgagcgt gttttataaa aaactcacag gtgtttgagg     3840

ccaaaacaga ttttagactt accttgaacg gataagaatc tatagttcac tgacacagta     3900

aaattaactc tgtgggtggg ggcggggggc atagctctaa tctaatatat aaaatgtgtg     3960

atgaatcaac aagatttcca caattcttct gtcaagctta ctacagtgaa agaatgggat     4020

tggcaagtaa cttctgactt actgtcagtt gtacttctgc tccatagaca tcagtattct     4080

gccatcattt ttgatgacta cctcagaaca taaaaaggaa cgtatatcac ataattccag     4140

tcacagtttt tggttcctct tttctttcaa gaactatata taaatgacct gttttcactt     4200

agcatccttt ggactctgca gtaggttgtc tgggtcaaga taactctcag tcacatttat     4260

attcatatta tgctaaaata gtaaaatgaa acctcattgt tggacataat ttagatataa     4320

ctaaaaagtt ctatgaagtg ggaaattccg tgttggctct ggagcagctt tgtctcctct     4380

gaaccaatat atcccaaacc aatatatgca aagcacctgg tacacaactg gtattttagt     4440

acatgttggt tcttttggtg caatctcagc tcactgcagc ttccgcctcc tagattcaaa     4500

caaacagttc tcctgcccca gcctccagag cacctaggac tccaggtgca tgctaccaca     4560

cctgactagt ttttatattt ttagtagaga ttgggtttta ccatattggc caggctggtc     4620

tcaaactcct gaccgcaggt gatccacctg cctcagcttc cccaagggct gggattacag     4680

gtgtgagcca ccatgcccag cctatttgtc acattatttg tcacatttat tttactttta     4740

tttatttttt gagatgaaat ttcgctcttg ttgcccaggc tggagtgcaa tggtgcagcc     4800

ttggctcact gcaacctccg cctcccaggg tcaagcaatt ctcctgcctc agcctcctga     4860

gtagctggga ttacaggcat gcaccaccac acccaggtaa ttttgtatct ttagtagaga     4920

tggggtttca ccatgttggt caggctgttc tcgaactcct gacctcaggt gatctgcctg     4980

ccttggcctc ccaaagtgct gggattacag gcgtgagcca ctgcgcctag ccgtcacatt     5040

tctaaacaag catgaaaggg gttcattttt gtcttcttct tgcctgccgt cagcatggtg     5100

gaaatggctc tgcctatgct catgcttctg gtgcccaatg ccttgcactg tgccattcaa     5160

cactatgaag agaaacaagt agccacacct caaaataatg tggctgtcaa caactggcct     5220

aaataaacct acacaaacca gtacttgcct tttgctggaa acattgatta tgtgctcctc     5280

acgtagtaga aagcggtatc ctgattagtc taacagttgt gttagacttt agggccagta     5340

ttgtcagcat ttatttattt atgtaccttt gttatgatgg gatatttttc atttgaaact     5400

tgttcataaa aatgtcaatg acattgatga ctgatttgta catatttttc atatagtttt     5460

gtttaaaaaa taattcacgc aaaatcttga agtcattttt gctattgaaa taaaccttaa     5520

ttaaaatatt tcatcatcaa aaaaaaaaaa aaaaaa                               5556


<210> 146
<211> 1765
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1765
<223> /mol_type="unassigned DNA"
      /note="OSMR (oncostatin M receptor)"
      /organism="Homo sapiens"

<400> 146
gcggccgcct ccccccggga ctgaagggag ggaattcctg tgggtcccag gagtgccaag      60

agtgcgcagc aagacgggaa attgcaaaag acctcacccc tctgccctcc cccgcggttt     120

tccagtaact cccgcccctc cgcgcttgcc ccgcagctga ttcatagccc cggcccgggc     180

cgcctctgca cgtccgcccc ggagcccgca cccgcgcccc acgcgccgcc gaggactcgg     240

cccggctcgt ggagcccttc gcccgcggca aaaccagaac tgatggctct atttgcagtc     300

tttcagacaa cattcttctt aacattgctg tccttgagga cttaccagag tgaagtcttg     360

gctgaacgtt taccattgac tcctgtatca cttaaagttt ccaccaattc tacgcgtcag     420

agtttgcact tacaatggac tgtccacaac cttccttatc atcaggaatt gaaaatggta     480

tttcagatcc agatcagtag gattgaaaca tccaatgtca tctgggtggg gaattacagc     540

accactgtga agtggaacca ggttctgcat tggagctggg aatctgagct ccctttggaa     600

tgtgccacac actttgtaag aataaagagt ttggtggacg atgccaagtt ccctgagcca     660

aatttctgga gcaactggag ttcctgggag gaagtcagtg tacaagattc tactggacag     720

gatatattgt tcgttttccc taaagataag ctggtggaag aaggcaccaa tgttaccatt     780

tgttacgttt ctaggaacat tcaaaataat gtatcctgtt atttggaagg gaaacagatt     840

catggagaac aacttgatcc acatgtaact gcattcaact tgaatagtgt gcctttcatt     900

aggaataaag ggacaaatat ctattgtgag gcaagtcaag gaaatgtcag tgaaggcatg     960

aaaggcatcg ttctttttgt ctcaaaagta cttgaggagc ccaaggactt ttcttgtgaa    1020

accgaggact tcaagacttt gcactgtact tgggatcctg ggacggacac tgccttgggg    1080

tggtctaaac aaccttccca aagctacact ttatttgaat cattttctgg ggaaaagaaa    1140

ctttgtacac acaaaaactg gtgtaattgg caaataactc aagactcaca agaaacctat    1200

aacttcacac tcatagctga aaattactta aggaagagaa gtgtcaatat cctttttaac    1260

ctgactcatc gaggtgagac tagagttgtc acagcccacc gtggccacta acgtgtcttt    1320

gtttcacaga ctgtgtgatc aagtaaatgt gctgtagatc tttgcctcat tcacagcgga    1380

ggtgagagtt agaatttata cctattgttc atgccacgtt tctcctcatg gatgcacgca    1440

tcccctatta tttgtttctt ttaataatgt cacgagcacc aatgagctta ctacccaact    1500

tcaaaactag gactctaaca ataacttctg tcatatctca tcctgtaacg cccccacctt    1560

cgctccttcc gccaagataa ttatcacttt aaattgtgtg cgtgtgtatt ctcatttctt    1620

atgtgatggt aaaaatgcct ttattttgtt tggttttaat gcatagaaag gacatcaagc    1680

tgtatgtaat aattcagtaa ttatgtttat ataatattaa attgctaata tttgcccata    1740

aaaaaaaaaa aaaaaaaaaa aaaaa                                          1765


<210> 147
<211> 979
<212> PRT
<213> Homo sapiens

<220> 
<223> OSMR (oncostatin M receptor)

<400> 147
Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      
Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          
Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              
His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  
Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  
Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      
Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         
Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             
Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 
Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 
Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     
Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         
Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             
Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 
Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 
Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     
Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         
Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             
Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 
Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 
Val Asn Ile Leu Phe Asn Leu Thr His Arg Val Tyr Leu Met Asn Pro 
                325                 330                 335     
Phe Ser Val Asn Phe Glu Asn Val Asn Ala Thr Asn Ala Ile Met Thr 
            340                 345                 350         
Trp Lys Val His Ser Ile Arg Asn Asn Phe Thr Tyr Leu Cys Gln Ile 
        355                 360                 365             
Glu Leu His Gly Glu Gly Lys Met Met Gln Tyr Asn Val Ser Ile Lys 
    370                 375                 380                 
Val Asn Gly Glu Tyr Phe Leu Ser Glu Leu Glu Pro Ala Thr Glu Tyr 
385                 390                 395                 400 
Met Ala Arg Val Arg Cys Ala Asp Ala Ser His Phe Trp Lys Trp Ser 
                405                 410                 415     
Glu Trp Ser Gly Gln Asn Phe Thr Thr Leu Glu Ala Ala Pro Ser Glu 
            420                 425                 430         
Ala Pro Asp Val Trp Arg Ile Val Ser Leu Glu Pro Gly Asn His Thr 
        435                 440                 445             
Val Thr Leu Phe Trp Lys Pro Leu Ser Lys Leu His Ala Asn Gly Lys 
    450                 455                 460                 
Ile Leu Phe Tyr Asn Val Val Val Glu Asn Leu Asp Lys Pro Ser Ser 
465                 470                 475                 480 
Ser Glu Leu His Ser Ile Pro Ala Pro Ala Asn Ser Thr Lys Leu Ile 
                485                 490                 495     
Leu Asp Arg Cys Ser Tyr Gln Ile Cys Val Ile Ala Asn Asn Ser Val 
            500                 505                 510         
Gly Ala Ser Pro Ala Ser Val Ile Val Ile Ser Ala Asp Pro Glu Asn 
        515                 520                 525             
Lys Glu Val Glu Glu Glu Arg Ile Ala Gly Thr Glu Gly Gly Phe Ser 
    530                 535                 540                 
Leu Ser Trp Lys Pro Gln Pro Gly Asp Val Ile Gly Tyr Val Val Asp 
545                 550                 555                 560 
Trp Cys Asp His Thr Gln Asp Val Leu Gly Asp Phe Gln Trp Lys Asn 
                565                 570                 575     
Val Gly Pro Asn Thr Thr Ser Thr Val Ile Ser Thr Asp Ala Phe Arg 
            580                 585                 590         
Pro Gly Val Arg Tyr Asp Phe Arg Ile Tyr Gly Leu Ser Thr Lys Arg 
        595                 600                 605             
Ile Ala Cys Leu Leu Glu Lys Lys Thr Gly Tyr Ser Gln Glu Leu Ala 
    610                 615                 620                 
Pro Ser Asp Asn Pro His Val Leu Val Asp Thr Leu Thr Ser His Ser 
625                 630                 635                 640 
Phe Thr Leu Ser Trp Lys Asp Tyr Ser Thr Glu Ser Gln Pro Gly Phe 
                645                 650                 655     
Ile Gln Gly Tyr His Val Tyr Leu Lys Ser Lys Ala Arg Gln Cys His 
            660                 665                 670         
Pro Arg Phe Glu Lys Ala Val Leu Ser Asp Gly Ser Glu Cys Cys Lys 
        675                 680                 685             
Tyr Lys Ile Asp Asn Pro Glu Glu Lys Ala Leu Ile Val Asp Asn Leu 
    690                 695                 700                 
Lys Pro Glu Ser Phe Tyr Glu Phe Phe Ile Thr Pro Phe Thr Ser Ala 
705                 710                 715                 720 
Gly Glu Gly Pro Ser Ala Thr Phe Thr Lys Val Thr Thr Pro Asp Glu 
                725                 730                 735     
His Ser Ser Met Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val 
            740                 745                 750         
Leu Leu Ile Met Val Met Cys Tyr Leu Lys Ser Gln Trp Ile Lys Glu 
        755                 760                 765             
Thr Cys Tyr Pro Asp Ile Pro Asp Pro Tyr Lys Ser Ser Ile Leu Ser 
    770                 775                 780                 
Leu Ile Lys Phe Lys Glu Asn Pro His Leu Ile Ile Met Asn Val Ser 
785                 790                 795                 800 
Asp Cys Ile Pro Asp Ala Ile Glu Val Val Ser Lys Pro Glu Gly Thr 
                805                 810                 815     
Lys Ile Gln Phe Leu Gly Thr Arg Lys Ser Leu Thr Glu Thr Glu Leu 
            820                 825                 830         
Thr Lys Pro Asn Tyr Leu Tyr Leu Leu Pro Thr Glu Lys Asn His Ser 
        835                 840                 845             
Gly Pro Gly Pro Cys Ile Cys Phe Glu Asn Leu Thr Tyr Asn Gln Ala 
    850                 855                 860                 
Ala Ser Asp Ser Gly Ser Cys Gly His Val Pro Val Ser Pro Lys Ala 
865                 870                 875                 880 
Pro Ser Met Leu Gly Leu Met Thr Ser Pro Glu Asn Val Leu Lys Ala 
                885                 890                 895     
Leu Glu Lys Asn Tyr Met Asn Ser Leu Gly Glu Ile Pro Ala Gly Glu 
            900                 905                 910         
Thr Ser Leu Asn Tyr Val Ser Gln Leu Ala Ser Pro Met Phe Gly Asp 
        915                 920                 925             
Lys Asp Ser Leu Pro Thr Asn Pro Val Glu Ala Pro His Cys Ser Glu 
    930                 935                 940                 
Tyr Lys Met Gln Met Ala Val Ser Leu Arg Leu Ala Leu Pro Pro Pro 
945                 950                 955                 960 
Thr Glu Asn Ser Ser Leu Ser Ser Ile Thr Leu Leu Asp Pro Gly Glu 
                965                 970                 975     
His Tyr Cys 
            

<210> 148
<211> 342
<212> PRT
<213> Homo sapiens

<220> 
<223> OSMR (oncostatin M receptor)

<400> 148
Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      
Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          
Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              
His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  
Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  
Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      
Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         
Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             
Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 
Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 
Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     
Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         
Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             
Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 
Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 
Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     
Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         
Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             
Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 
Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 
Val Asn Ile Leu Phe Asn Leu Thr His Arg Gly Glu Thr Arg Val Val 
                325                 330                 335     
Thr Ala His Arg Gly His 
            340         

<210> 149
<211> 2397
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2397
<223> /mol_type="unassigned DNA"
      /note="ITGB6 (integrin, beta 6)"
      /organism="Homo sapiens"

<400> 149
gcaagaactg aaacgaatgg ggattgaact gctttgcctg ttctttctat ttctaggaag      60

gaatgatcac gtacaaggtg gctgtgccct gggaggtgca gaaacctgtg aagactgcct     120

gcttattgga cctcagtgtg cctggtgtgc tcaggagaat tttactcatc catctggagt     180

tggcgaaagg tgtgataccc cagcaaacct tttagctaaa ggatgtcaat taaacttcat     240

cgaaaaccct gtctcccaag tagaaatact taaaaataag cctctcagtg taggcagaca     300

gaaaaatagt tctgacattg ttcagattgc gcctcaaagc ttgatcctta agttgagacc     360

aggtggtgcg cagactctgc aggtgcatgt ccgccagact gaggactacc cggtggattt     420

gtattacctc atggacctct ccgcctccat ggatgacgac ctcaacacaa taaaggagct     480

gggctcccgg ctttccaaag agatgtctaa attaaccagc aactttagac tgggcttcgg     540

atcttttgtg gaaaaacctg tatccccttt cgtgaaaaca acaccagaag aaattgccaa     600

cccttgcagt agtattccat acttctgttt acctacattt ggattcaagc acattttgcc     660

attgacaaat gatgctgaaa gattcaatga aattgtgaag aatcagaaaa tttctgctaa     720

tattgacaca cccgaaggtg gatttgatgc aattatgcaa gctgctgtgt gtaaggaaaa     780

aattggctgg cggaatgact ccctccacct cctggtcttt gtgagtgatg ctgattctca     840

ttttggaatg gacagcaaac tagcaggcat cgtcattcct aatgacgggc tctgtcactt     900

ggacagcaag aatgaatact ccatgtcaac tgtcttggaa tatccaacaa ttggacaact     960

cattgataaa ctggtacaaa acaacgtgtt attgatcttc gctgtaaccc aagaacaagt    1020

tcatttatat gagaattacg caaaacttat tcctggagct acagtaggtc tacttcagaa    1080

ggactccgga aacattctcc agctgatcat ctcagcttat gaagaactgc ggtctgaggt    1140

ggaactggaa gtattaggag acactgaagg actcaacttg tcatttacag ccatctgtaa    1200

caacggtacc ctcttccaac accaaaagaa atgctctcac atgaaagtgg gagacacagc    1260

ttccttcagc gtgactgtga atatcccaca ctgcgagaga agaagcaggc acattatcat    1320

aaagcctgtg gggctggggg atgccctgga attacttgtc agcccagaat gcaactgcga    1380

ctgtcagaaa gaagtggaag tgaacagctc caaatgtcac cacgggaacg gctctttcca    1440

gtgtggggtg tgtgcctgcc accctggcca catggggcct cgctgtgagt gtggcgagga    1500

catgctgagc acagattcct gcaaggaggc cccagatcat ccctcctgca gcggaagggg    1560

tgactgctac tgtgggcagt gtatctgcca cttgtctccc tatggaaaca tttatgggcc    1620

ttattgccag tgtgacaatt tctcctgcgt gagacacaaa gggctgctct gcggaggtaa    1680

cggcgactgt gactgtggtg aatgtgtgtg caggagcggc tggactggcg agtactgcaa    1740

ctgcaccacc agcacggact cctgcgtctc tgaagatgga gtgctctgca gcgggcgcgg    1800

ggactgtgtt tgtggcaagt gtgtttgcac aaaccctgga gcctcaggac caacctgtga    1860

acgatgtcct acctgtggtg acccctgtaa ctctaaacgg agctgcattg agtgccacct    1920

gtcagcagct ggccaagccc gagaagaatg tgtggacaag tgcaaactag ctggtgcgac    1980

catcagtgaa gaagaagatt tctcaaagga tggttctgtt tcctgctctc tgcaaggaga    2040

aaatgaatgt cttattacat tcctaataac tacagataat gaggggaaaa ccatcattca    2100

cagcatcaat gaaaaagatt gtccgaagcc tccaaacatt cccatgatca tgttaggggt    2160

ttccctggct attcttctca tcggggttgt cctactgtgc atctggaagc tactggtgtc    2220

atttcatgat cgtaaagaag ttgccaaatt tgaagcagaa cgatcaaaag ccaagtggca    2280

aacgggaacc aatccactct acagaggatc cacaagtact tttaaaaatg taacttataa    2340

acacagggaa aaacaaaagg tagacctttc cacagattgc tagaactact ttatgca       2397


<210> 150
<211> 788
<212> PRT
<213> Homo sapiens

<220> 
<223> ITGB6 (integrin, beta 6)

<400> 150
Met Gly Ile Glu Leu Leu Cys Leu Phe Phe Leu Phe Leu Gly Arg Asn 
1               5                   10                  15      
Asp His Val Gln Gly Gly Cys Ala Leu Gly Gly Ala Glu Thr Cys Glu 
            20                  25                  30          
Asp Cys Leu Leu Ile Gly Pro Gln Cys Ala Trp Cys Ala Gln Glu Asn 
        35                  40                  45              
Phe Thr His Pro Ser Gly Val Gly Glu Arg Cys Asp Thr Pro Ala Asn 
    50                  55                  60                  
Leu Leu Ala Lys Gly Cys Gln Leu Asn Phe Ile Glu Asn Pro Val Ser 
65                  70                  75                  80  
Gln Val Glu Ile Leu Lys Asn Lys Pro Leu Ser Val Gly Arg Gln Lys 
                85                  90                  95      
Asn Ser Ser Asp Ile Val Gln Ile Ala Pro Gln Ser Leu Ile Leu Lys 
            100                 105                 110         
Leu Arg Pro Gly Gly Ala Gln Thr Leu Gln Val His Val Arg Gln Thr 
        115                 120                 125             
Glu Asp Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Ala Ser 
    130                 135                 140                 
Met Asp Asp Asp Leu Asn Thr Ile Lys Glu Leu Gly Ser Arg Leu Ser 
145                 150                 155                 160 
Lys Glu Met Ser Lys Leu Thr Ser Asn Phe Arg Leu Gly Phe Gly Ser 
                165                 170                 175     
Phe Val Glu Lys Pro Val Ser Pro Phe Val Lys Thr Thr Pro Glu Glu 
            180                 185                 190         
Ile Ala Asn Pro Cys Ser Ser Ile Pro Tyr Phe Cys Leu Pro Thr Phe 
        195                 200                 205             
Gly Phe Lys His Ile Leu Pro Leu Thr Asn Asp Ala Glu Arg Phe Asn 
    210                 215                 220                 
Glu Ile Val Lys Asn Gln Lys Ile Ser Ala Asn Ile Asp Thr Pro Glu 
225                 230                 235                 240 
Gly Gly Phe Asp Ala Ile Met Gln Ala Ala Val Cys Lys Glu Lys Ile 
                245                 250                 255     
Gly Trp Arg Asn Asp Ser Leu His Leu Leu Val Phe Val Ser Asp Ala 
            260                 265                 270         
Asp Ser His Phe Gly Met Asp Ser Lys Leu Ala Gly Ile Val Ile Pro 
        275                 280                 285             
Asn Asp Gly Leu Cys His Leu Asp Ser Lys Asn Glu Tyr Ser Met Ser 
    290                 295                 300                 
Thr Val Leu Glu Tyr Pro Thr Ile Gly Gln Leu Ile Asp Lys Leu Val 
305                 310                 315                 320 
Gln Asn Asn Val Leu Leu Ile Phe Ala Val Thr Gln Glu Gln Val His 
                325                 330                 335     
Leu Tyr Glu Asn Tyr Ala Lys Leu Ile Pro Gly Ala Thr Val Gly Leu 
            340                 345                 350         
Leu Gln Lys Asp Ser Gly Asn Ile Leu Gln Leu Ile Ile Ser Ala Tyr 
        355                 360                 365             
Glu Glu Leu Arg Ser Glu Val Glu Leu Glu Val Leu Gly Asp Thr Glu 
    370                 375                 380                 
Gly Leu Asn Leu Ser Phe Thr Ala Ile Cys Asn Asn Gly Thr Leu Phe 
385                 390                 395                 400 
Gln His Gln Lys Lys Cys Ser His Met Lys Val Gly Asp Thr Ala Ser 
                405                 410                 415     
Phe Ser Val Thr Val Asn Ile Pro His Cys Glu Arg Arg Ser Arg His 
            420                 425                 430         
Ile Ile Ile Lys Pro Val Gly Leu Gly Asp Ala Leu Glu Leu Leu Val 
        435                 440                 445             
Ser Pro Glu Cys Asn Cys Asp Cys Gln Lys Glu Val Glu Val Asn Ser 
    450                 455                 460                 
Ser Lys Cys His His Gly Asn Gly Ser Phe Gln Cys Gly Val Cys Ala 
465                 470                 475                 480 
Cys His Pro Gly His Met Gly Pro Arg Cys Glu Cys Gly Glu Asp Met 
                485                 490                 495     
Leu Ser Thr Asp Ser Cys Lys Glu Ala Pro Asp His Pro Ser Cys Ser 
            500                 505                 510         
Gly Arg Gly Asp Cys Tyr Cys Gly Gln Cys Ile Cys His Leu Ser Pro 
        515                 520                 525             
Tyr Gly Asn Ile Tyr Gly Pro Tyr Cys Gln Cys Asp Asn Phe Ser Cys 
    530                 535                 540                 
Val Arg His Lys Gly Leu Leu Cys Gly Gly Asn Gly Asp Cys Asp Cys 
545                 550                 555                 560 
Gly Glu Cys Val Cys Arg Ser Gly Trp Thr Gly Glu Tyr Cys Asn Cys 
                565                 570                 575     
Thr Thr Ser Thr Asp Ser Cys Val Ser Glu Asp Gly Val Leu Cys Ser 
            580                 585                 590         
Gly Arg Gly Asp Cys Val Cys Gly Lys Cys Val Cys Thr Asn Pro Gly 
        595                 600                 605             
Ala Ser Gly Pro Thr Cys Glu Arg Cys Pro Thr Cys Gly Asp Pro Cys 
    610                 615                 620                 
Asn Ser Lys Arg Ser Cys Ile Glu Cys His Leu Ser Ala Ala Gly Gln 
625                 630                 635                 640 
Ala Arg Glu Glu Cys Val Asp Lys Cys Lys Leu Ala Gly Ala Thr Ile 
                645                 650                 655     
Ser Glu Glu Glu Asp Phe Ser Lys Asp Gly Ser Val Ser Cys Ser Leu 
            660                 665                 670         
Gln Gly Glu Asn Glu Cys Leu Ile Thr Phe Leu Ile Thr Thr Asp Asn 
        675                 680                 685             
Glu Gly Lys Thr Ile Ile His Ser Ile Asn Glu Lys Asp Cys Pro Lys 
    690                 695                 700                 
Pro Pro Asn Ile Pro Met Ile Met Leu Gly Val Ser Leu Ala Ile Leu 
705                 710                 715                 720 
Leu Ile Gly Val Val Leu Leu Cys Ile Trp Lys Leu Leu Val Ser Phe 
                725                 730                 735     
His Asp Arg Lys Glu Val Ala Lys Phe Glu Ala Glu Arg Ser Lys Ala 
            740                 745                 750         
Lys Trp Gln Thr Gly Thr Asn Pro Leu Tyr Arg Gly Ser Thr Ser Thr 
        755                 760                 765             
Phe Lys Asn Val Thr Tyr Lys His Arg Glu Lys Gln Lys Val Asp Leu 
    770                 775                 780                 
Ser Thr Asp Cys 
785             

<210> 151
<211> 7889
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..7889
<223> /mol_type="unassigned DNA"
      /note="AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4)"
      /organism="Homo sapiens"

<400> 151
atgggtggag tctcgctttt tctttccagt gttggctgac ttacagctct tataaactag       60

tggcaatttc tgaacccagc cggctccatc tcagcttctg gtttctaagt ccatgtgcca      120

aaggctgcca ggaaggagac gccttcctga gtcctggatc tttcttcctt ctggaaatct      180

ttgactgtgg gtagttattt atttctgaat aagagcgtcc acgcatcatg gacctcgcgg      240

gactgctgaa gtctcagttc ctgtgccacc tggtcttctg ctacgtcttt attgcctcag      300

ggctaatcat caacaccatt cagctcttca ctctcctcct ctggcccatt aacaagcagc      360

tcttccggaa gatcaactgc agactgtcct attgcatctc aagccagctg gtgatgctgc      420

tggagtggtg gtcgggcacg gaatgcacca tcttcacgga cccgcgcgcc tacctcaagt      480

atgggaagga aaatgccatc gtggttctca accacaagtt tgaaattgac tttctgtgtg      540

gctggagcct gtccgaacgc tttgggctgt tagggggctc caaggtcctg gccaagaaag      600

agctggccta tgtcccaatt atcggctgga tgtggtactt caccgagatg gtcttctgtt      660

cgcgcaagtg ggagcaggat cgcaagacgg ttgccaccag tttgcagcac ctccgggact      720

accccgagaa gtattttttc ctgattcact gtgagggcac acggttcacg gagaagaagc      780

atgagatcag catgcaggtg gcccgggcca aggggctgcc tcgcctcaag catcacctgt      840

tgccacgaac caagggcttc gccatcaccg tgaggagctt gagaaatgta gtttcagctg      900

tatatgactg tacactcaat ttcagaaata atgaaaatcc aacactgctg ggagtcctaa      960

acggaaagaa ataccatgca gatttgtatg ttaggaggat cccactggaa gacatccctg     1020

aagacgatga cgagtgctcg gcctggctgc acaagctcta ccaggagaag gatgcctttc     1080

aggaggagta ctacaggacg ggcaccttcc cagagacgcc catggtgccc ccccggcggc     1140

cctggaccct cgtgaactgg ctgttttggg cctcgctggt gctctaccct ttcttccagt     1200

tcctggtcag catgatcagg agcgggtctt ccctgacgct ggccagcttc atcctcgtct     1260

tctttgtggc ctccgtggga gttcgatgga tgattggtgt gacggaaatt gacaagggct     1320

ctgcctacgg caactctgac agcaagcaga aactgaatga ctgactcagg gaggtgtcac     1380

catccgaagg gaaccttggg gaactggtgg cctctgcata tcctccttag tgggacacgg     1440

tgacaaaggc tgggtgagcc cctgctgggc acggcggaag tcacgacctc tccagccagg     1500

gagtctggtc tcaaggccgg atggggagga agatgttttg taatcttttt ttccccatgt     1560

gctttagtgg gctttggttt tctttttgtg cgagtgtgtg tgagaatggc tgtgtggtga     1620

gtgtgaactt tgttctgtga tcatagaaag ggtattttag gctgcagggg agggcagggc     1680

tggggaccga aggggacaag ttcccctttc atcctttggt gctgagtttt ctgtaaccct     1740

tggttgccag agataaagtg aaaagtgctt taggtgagat gactaaatta tgcctccaag     1800

aaaaaaaaat taaagtgctt ttctgggtca tctgtggtgt atgttgacat ggaccgctgc     1860

ccctccatcc tgcccttgcc cgtggctttg gtgtttcaga tcctactcac gggaggcagc     1920

tgccgcggag gtgtgggcag ctgagagggg tgggcaggcc agcacagctc ctggcaggag     1980

acacaggtcc aggagcccgt gagcatttgt gagagcagag atggcaagca cgtgcgtgga     2040

gaccaacgaa gcgtgtccct ggcacacagc aagggagagt ttcgctcggt ctctgcagtg     2100

cagtctcctg gcgtaagtct tgaagatgga cccaactccc tgaagaaatg gatcttgaaa     2160

ttgaacacaa acatcatgaa cgtacagcct gggcattctg cagtgatttg tgagatgagc     2220

ttgcatcgac tgttcctctc agcagtgaca gccaaagtca cccctgataa aatgcagttt     2280

cactttataa aatgcctcgc cccttcccag catgtagagc ttgtctgcag ccctaaagga     2340

gccaggtcct gctctgatga gggtcaaatc agagccgaca tcccatgtac aaaaaacccc     2400

caggcttctg ccttccttcc gggctcctgt ctgctcccat tttactccac ggaatagttc     2460

tgccctgtag catctccagc ggcctttgca gactgctgtc agccaacagg tgccaaaaat     2520

gcaaaagaag aagaaactaa aagcagtgct atttttgcag aacaaatgct agctattaaa     2580

tcatcttagg ccaagacacc aatggcactt ggaccgatag gtatttggag catgagttag     2640

gaaggatatg tctttctcca ggtgcgcagc tgaaagttgc tgagaaaagc tgcctgtgtt     2700

gctgtggtaa catgagaagg aatgaacagc tctatacaaa aactggccac acattataag     2760

gcctattcta tgcagttatg tttttggcta tttgctcatt tagtcattgt ttatcaacca     2820

aactaggtaa gccaaggagt tacaagacag ctctagagaa gctccctctg cttacaggac     2880

aataatgcat tgtttgtttg ttgatacaaa tgaattattt gaatccacag aagtgaaaaa     2940

gggaaaaaat cctggctgac ttgtgggaag agcgtactgc agagcctagg gcctgagtta     3000

actcgctggc ggccctgcag gcaggcttga tgggagcgcc cagcacatct gcccaccctg     3060

cacagggcat gaagcaccgt gtgcagagat ctgtgggcaa aagcccagga cgtgacctta     3120

ggcaagaggg gtccttggag aagtggaggt gtgcatggtg tgtagccttg cgtgtctgtg     3180

agcacgccct agtggacctg cgcctggatt atcgggccag tctctcggag gggtccgtga     3240

tgctgagtta cgccattcac ctgaactctg cagctcatcg gctgtaggat ttgggtgaga     3300

cacttttcct tgctgactca tttccccatc tgcaaaatgg gggtgacgat atctacctct     3360

tggggtgtgt caagggtaaa agagcacact ttaagaatcc taaagcacta agccaaggat     3420

gaaagactag aaagctgcct ctatgttgct actctcaaaa atgctcagaa attttcttgt     3480

cgtactaaaa atgtgttatt tttctcattt tcattcttcc attcaacaca gaagtaatct     3540

aagtaagttc taaaaacata gatccggggg cccacagaca ttcaattttc ttctgaattg     3600

gctctggtat cacacaacac acaagcaagc aaacagcctg cctgctaggg ccttgggttc     3660

caggctggag gaatgcaggc agaaatctct taggaaataa ctaagtgagc gccaagtttt     3720

gaattgcctt agagccgaaa gagaatgtgg cgtgctgggg agagatctgg acctctttct     3780

catcagtcat ttgacctgtc cacgaagaac aattttgtta tgcagcctgg gaacctggtt     3840

tccttacacc ctgcgccctt aatgacacag acaaccacgg gtactcctgg acggaagctc     3900

atcacgcctc ctcaaatacc ttcacccatg ttcaggtcac acggaggtca ccatctcctc     3960

agcacacaac aactgctttg gttcccaggg ttattttttc tacgagttga aaacccacgg     4020

agcctaagcc atctttttgt cccctaagga gagccccata gactaagagc tacacttcct     4080

gtctgtcttt cccacctttc catctcattc tagcttaaag cttatcacgc tactgagagc     4140

ctgttctgta gttcaaggtg gcagagaaaa atacgaacct tgagtgaaat ctggagagca     4200

gtgcagggtc atccccagac gtgacgggcc atatcctagg cgactcctgc agcttataga     4260

agcagggaat ttaatggact tcttccagga aagccagccc acggggactc ttaaaaagac     4320

accaaccatt tggaagatgc agcttgaggt ctgggggact ggactgattc tgccaccata     4380

tagtgaacac gattaatcgg gaggaagaag taaggcactc tgtgagttag tctaccaccc     4440

tattgacttt gacagagaga aaaccaactt ttttcatatg atcacacagt agtactggaa     4500

tatctcgact gcaatatcct ctaaacaaat gcatgcaaag ctttgtaaaa gcagctgatg     4560

attaaaaaaa ttttaaaaca ttagggtttt tctaatatat ccatatgtgg gacagtgatt     4620

taaatgtcat taattgtcca gccacaactt gtaacagtga tgtgaaagac acaaaaaagg     4680

ccccactgga gtggaggagt ggtctggctg gtccccaagc aaaacagaat gggcttcgca     4740

taggctttag aacttattca taaatattga ccaaagtgtg aagcaaggta tccagtgaag     4800

attctctagg gtctctactt ctgctcaaga gatttaatcc agctttctct aaagcagtgg     4860

tccagacttg ccacatacta ggttaaagat aaagtgagaa aaacaaatac tttggtttgc     4920

acgtctcttg aggggcccta ggctgtatgg aggaatattt agaggaatat ttgtgagctg     4980

ccatttgtgt ttaaaagaac atgaaagcaa gacgggccct aacccgcctg tgtctgtagc     5040

tgaccaggag gccactgctt ccttccccca gagcttctag gagagccccc caaaatgcaa     5100

ctctccaagg tcctgtggag tagtcccctc ataatgcctc caccacacct gtgtctcacg     5160

atgccttaac tgacgtagct cctaagtgat gttcacagag aaggaaatac ttaggcaagc     5220

ccatgtgtaa catgctcaca gatgtgctgg ctttgccaat gctttcggac tccaccatgc     5280

tttctgattc ttctggtcct agtcacgcct tggcacgggg cagaagcggc cgagctatgc     5340

tgacaggtgc tgctgagagc caacagccat tcagccgaga aggcgtttct aggtgagggc     5400

atgagagctg gcattccagg ctgctgagtg cggcatctgc aggtgcacca cattgctcca     5460

cggtgtgttc agaagagacc agcatcttga atctcaggct ctgggctcat tctttgcctc     5520

tgccaaggga ccattcaggg gcttcaagcc agctgctgaa aatccccctt ttctggattt     5580

ttccccatct atataaggat atggtggctg tgtggacaag aaattggttt catctcagaa     5640

gggtgcttcc ctacaaagat cttcagaaat ttaattgaaa acaatttttt gaactttttt     5700

tgtttggcca ggatgaatga agctgaagtc acatcctgaa tgtgcatgcc agacaaaggg     5760

taagcaagca gtctttacaa atgccaatcc ctctgcactc caaaaccgga gcccgtaatg     5820

aaggcccagg ttccagtcat cacaggatcc cccaagccag cacagtgcct gatgcctccc     5880

taggcattag cacatcccag cactctaatt cacatcctca gcatccctgc ctcctgcatc     5940

cagggcttag gttgagtgtt tccagagtgt caagtacatt taaacacaaa ccaaatactc     6000

cagggttttg acctgtcaca atggcttttg aaaacaacag acgtacaatt tgagagaagg     6060

actcgatgga cttcttaggc tgaggactaa ggacatgttg ctgttcctct tggtccagga     6120

cattcaatac cattcacagc attcatcacc aactgacata gtatcgatca cgacattcaa     6180

ctgtttgaaa ttactgctat tttggtcaaa aactaagaaa tcagaaattg cacctacata     6240

gtgtgtctcc tcattggagt cccatctctc tgagcacagg gatgggctcc tgagctcaca     6300

gccctgccct gcccccccag cagggcctca ccctcatggc cctcagtgaa tagtgactac     6360

atgaaggggg cacttactag aggcctgagt aatggaattt caattagctt ctgcttccct     6420

tttctaaaaa agaaccacct ttcttaagaa taattaggcc aaaataaact tgagtaattt     6480

gtacagtcaa tattttgaag tttcggagtt accagtgaaa tagcaaagct gttctccagg     6540

aaaggacatc caggttccca cccaggcctt ccttcctcag ctcctgcagc ctcatcctag     6600

tttaatatga aggttgtgaa tgggttaaaa agcagttctt aagcacctac ttagatcttt     6660

tcagtatctg gaaatagcac ccagggctgt gttagtaaag cttttcactg ggtaagagtc     6720

atacaatttt tacatttaat ttgttttttt aaaacaaggc agtcttgttt tacatattgg     6780

aatgactaga tattttttga catttctggc acctctggtt ctgctgaatt ttaagggagg     6840

tgagtggtat gtacacaaag ttaagattgc tgcataataa ttcctttgca tttccaaaat     6900

aaattacaca aatgtcactt ttccttttct attccatagt actagtttta gccagatctt     6960

tgccaaacat tctaggacat tcagaaaagt catccatgga attttggaat gccattctct     7020

ctgtatcttt gcagatcatg aggaaggaaa gttgatgaac tagtacggga tggctcagac     7080

ttgtaaagtg tctaagtcac aacgctgcag agccagcttc cgggtagcaa tggcatggcc     7140

tcagctgtgc caaggctaca actggagctt ccttactcgc atctgaggca aacacagcaa     7200

ggctggccca ggccgcccac agtcaacaga tgttcacggg agatggatca gcccctcttt     7260

tgcttgttct atcaaggaaa gagatctaac catgggcaag ggtggaacac acccggttca     7320

ggtcagggaa tgagttgctc taagtgaaca gtgaattctt acttctcagc ctgtatcaat     7380

tgtacccagg gttcatgatt actgtgaccc actaagggat gatctttgag gaaacagacc     7440

tggagggagg taatttaagg agggaaagcg agtgggtttt acagactgct ttgtggcgac     7500

attcaggaac agaccattca atggatgact tttcagtaca taaaagcaag cagtaatggc     7560

caggagagag caaagatgcc ctaagaatga catcagactg accaaatgtg ccttttcaaa     7620

taagttatga gaacgaatga attggaatta gagcaaggta ttggacagaa ccatgctagt     7680

ctttgagaga acgtgtggat tgggtggatg tttggaccga atgaatggta actttttaat     7740

gtgaaacaga gaactgatat atgggctgtc atgtcaccct agggtactgt cgctctgtca     7800

tgtgtagcaa tctttccaaa tttttgttgg tgggctgaac aaagataaaa ctaataaagt     7860

atgtgtggat accactagaa aaaaaaaaa                                       7889


<210> 152
<211> 378
<212> PRT
<213> Homo sapiens

<220> 
<223> AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4)

<400> 152
Met Asp Leu Ala Gly Leu Leu Lys Ser Gln Phe Leu Cys His Leu Val 
1               5                   10                  15      
Phe Cys Tyr Val Phe Ile Ala Ser Gly Leu Ile Ile Asn Thr Ile Gln 
            20                  25                  30          
Leu Phe Thr Leu Leu Leu Trp Pro Ile Asn Lys Gln Leu Phe Arg Lys 
        35                  40                  45              
Ile Asn Cys Arg Leu Ser Tyr Cys Ile Ser Ser Gln Leu Val Met Leu 
    50                  55                  60                  
Leu Glu Trp Trp Ser Gly Thr Glu Cys Thr Ile Phe Thr Asp Pro Arg 
65                  70                  75                  80  
Ala Tyr Leu Lys Tyr Gly Lys Glu Asn Ala Ile Val Val Leu Asn His 
                85                  90                  95      
Lys Phe Glu Ile Asp Phe Leu Cys Gly Trp Ser Leu Ser Glu Arg Phe 
            100                 105                 110         
Gly Leu Leu Gly Gly Ser Lys Val Leu Ala Lys Lys Glu Leu Ala Tyr 
        115                 120                 125             
Val Pro Ile Ile Gly Trp Met Trp Tyr Phe Thr Glu Met Val Phe Cys 
    130                 135                 140                 
Ser Arg Lys Trp Glu Gln Asp Arg Lys Thr Val Ala Thr Ser Leu Gln 
145                 150                 155                 160 
His Leu Arg Asp Tyr Pro Glu Lys Tyr Phe Phe Leu Ile His Cys Glu 
                165                 170                 175     
Gly Thr Arg Phe Thr Glu Lys Lys His Glu Ile Ser Met Gln Val Ala 
            180                 185                 190         
Arg Ala Lys Gly Leu Pro Arg Leu Lys His His Leu Leu Pro Arg Thr 
        195                 200                 205             
Lys Gly Phe Ala Ile Thr Val Arg Ser Leu Arg Asn Val Val Ser Ala 
    210                 215                 220                 
Val Tyr Asp Cys Thr Leu Asn Phe Arg Asn Asn Glu Asn Pro Thr Leu 
225                 230                 235                 240 
Leu Gly Val Leu Asn Gly Lys Lys Tyr His Ala Asp Leu Tyr Val Arg 
                245                 250                 255     
Arg Ile Pro Leu Glu Asp Ile Pro Glu Asp Asp Asp Glu Cys Ser Ala 
            260                 265                 270         
Trp Leu His Lys Leu Tyr Gln Glu Lys Asp Ala Phe Gln Glu Glu Tyr 
        275                 280                 285             
Tyr Arg Thr Gly Thr Phe Pro Glu Thr Pro Met Val Pro Pro Arg Arg 
    290                 295                 300                 
Pro Trp Thr Leu Val Asn Trp Leu Phe Trp Ala Ser Leu Val Leu Tyr 
305                 310                 315                 320 
Pro Phe Phe Gln Phe Leu Val Ser Met Ile Arg Ser Gly Ser Ser Leu 
                325                 330                 335     
Thr Leu Ala Ser Phe Ile Leu Val Phe Phe Val Ala Ser Val Gly Val 
            340                 345                 350         
Arg Trp Met Ile Gly Val Thr Glu Ile Asp Lys Gly Ser Ala Tyr Gly 
        355                 360                 365             
Asn Ser Asp Ser Lys Gln Lys Leu Asn Asp 
    370                 375             

<210> 153
<211> 1863
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1863
<223> /mol_type="unassigned DNA"
      /note="ASS1 (argininosuccinate synthase 1)"
      /organism="Homo sapiens"

<400> 153
gccggcgcgc ccctgggagg gtgagccggc gccgggccca ggcccggacc tggtgggagg      60

cggggggagg tggggacgag gcctggggag gcgggccccg cccatctgca ggtggctgtg     120

aacgctgagc ggctccaggc gggggccggg cccgggggcg gggtctgtgg cgcgcgtccc     180

cgccacgtgt ccccggtcac cggccctgcc cccgggccct gtgcttataa cctgggatgg     240

gcacccctgc cagtcctgct ctgccgcctg ccaccgctgc ccgagcccga gtggttcact     300

gcactgtgaa aacagattcc agacgccggg aactcacgcc tccaatccca gacgctatgt     360

ccagcaaagg ctccgtggtt ctggcctaca gtggcggcct ggacacctcg tgcatcctcg     420

tgtggctgaa ggaacaaggc tatgacgtca ttgcctatct ggccaacatt ggccagaagg     480

aagacttcga ggaagccagg aagaaggcac tgaagcttgg ggccaaaaag gtgttcattg     540

aggatgtcag cagggagttt gtggaggagt tcatctggcc ggccatccag tccagcgcac     600

tgtatgagga ccgctacctc ctgggcacct ctcttgccag gccctgcatc gcccgcaaac     660

aagtggaaat cgcccagcgg gagggggcca agtatgtgtc ccacggcgcc acaggaaagg     720

ggaacgatca ggtccggttt gagctcagct gctactcact ggccccccag ataaaggtca     780

ttgctccctg gaggatgcct gaattctaca accggttcaa gggccgcaat gacctgatgg     840

agtacgcaaa gcaacacggg attcccatcc cggtcactcc caagaacccg tggagcatgg     900

atgagaacct catgcacatc agctacgagg ctggaatcct ggagaacccc aagaaccaag     960

cgcctccagg tctctacacg aagacccagg acccagccaa agcccccaac acccctgaca    1020

ttctcgagat cgagttcaaa aaaggggtcc ctgtgaaggt gaccaacgtc aaggatggca    1080

ccacccacca gacctccttg gagctcttca tgtacctgaa cgaagtcgcg ggcaagcatg    1140

gcgtgggccg tattgacatc gtggagaacc gcttcattgg aatgaagtcc cgaggtatct    1200

acgagacccc agcaggcacc atcctttacc atgctcattt agacatcgag gccttcacca    1260

tggaccggga agtgcgcaaa atcaaacaag gcctgggctt gaaatttgct gagctggtgt    1320

ataccggttt ctggcacagc cctgagtgtg aatttgtccg ccactgcatc gccaagtccc    1380

aggagcgagt ggaagggaaa gtgcaggtgt ccgtcctcaa gggccaggtg tacatcctcg    1440

gccgggagtc cccactgtct ctctacaatg aggagctggt gagcatgaac gtgcagggtg    1500

attatgagcc aactgatgcc accgggttca tcaacatcaa ttccctcagg ctgaaggaat    1560

atcatcgtct ccagagcaag gtcactgcca aatagacccg tgtacaatga ggagctgggg    1620

cctcctcaat ttgcagatcc cccaagtaca ggcgctaatt gttgtgataa tttgtaattg    1680

tgacttgttc tccccggctg gcagcgtagt ggggctgcca ggccccagct ttgttccctg    1740

gtccccctga agcctgcaaa cgttgtcatc gaagggaagg gtggggggca gctgcggtgg    1800

ggagctataa aaatgacaat taaaagagac actagtcttt tatttctaaa aaaaaaaaaa    1860

aaa                                                                  1863


<210> 154
<211> 1801
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1801
<223> /mol_type="unassigned DNA"
      /note="ASS1 (argininosuccinate synthase 1)"
      /organism="Homo sapiens"

<400> 154
gccggcgcgc ccctgggagg gtgagccggc gccgggccca ggcccggacc tggtgggagg      60

cggggggagg tggggacgag gcctggggag gcgggccccg cccatctgca ggtggctgtg     120

aacgctgagc ggctccaggc gggggccggg cccgggggcg gggtctgtgg cgcgcgtccc     180

cgccacgtgt ccccggtcac cggccctgcc cccgggccct gtgcttataa cctgggatgg     240

gcacccctgc cagtcctgct ctgccgcctg ccaccgctgc ccgagcccga cgctatgtcc     300

agcaaaggct ccgtggttct ggcctacagt ggcggcctgg acacctcgtg catcctcgtg     360

tggctgaagg aacaaggcta tgacgtcatt gcctatctgg ccaacattgg ccagaaggaa     420

gacttcgagg aagccaggaa gaaggcactg aagcttgggg ccaaaaaggt gttcattgag     480

gatgtcagca gggagtttgt ggaggagttc atctggccgg ccatccagtc cagcgcactg     540

tatgaggacc gctacctcct gggcacctct cttgccaggc cctgcatcgc ccgcaaacaa     600

gtggaaatcg cccagcggga gggggccaag tatgtgtccc acggcgccac aggaaagggg     660

aacgatcagg tccggtttga gctcagctgc tactcactgg ccccccagat aaaggtcatt     720

gctccctgga ggatgcctga attctacaac cggttcaagg gccgcaatga cctgatggag     780

tacgcaaagc aacacgggat tcccatcccg gtcactccca agaacccgtg gagcatggat     840

gagaacctca tgcacatcag ctacgaggct ggaatcctgg agaaccccaa gaaccaagcg     900

cctccaggtc tctacacgaa gacccaggac ccagccaaag cccccaacac ccctgacatt     960

ctcgagatcg agttcaaaaa aggggtccct gtgaaggtga ccaacgtcaa ggatggcacc    1020

acccaccaga cctccttgga gctcttcatg tacctgaacg aagtcgcggg caagcatggc    1080

gtgggccgta ttgacatcgt ggagaaccgc ttcattggaa tgaagtcccg aggtatctac    1140

gagaccccag caggcaccat cctttaccat gctcatttag acatcgaggc cttcaccatg    1200

gaccgggaag tgcgcaaaat caaacaaggc ctgggcttga aatttgctga gctggtgtat    1260

accggtttct ggcacagccc tgagtgtgaa tttgtccgcc actgcatcgc caagtcccag    1320

gagcgagtgg aagggaaagt gcaggtgtcc gtcctcaagg gccaggtgta catcctcggc    1380

cgggagtccc cactgtctct ctacaatgag gagctggtga gcatgaacgt gcagggtgat    1440

tatgagccaa ctgatgccac cgggttcatc aacatcaatt ccctcaggct gaaggaatat    1500

catcgtctcc agagcaaggt cactgccaaa tagacccgtg tacaatgagg agctggggcc    1560

tcctcaattt gcagatcccc caagtacagg cgctaattgt tgtgataatt tgtaattgtg    1620

acttgttctc cccggctggc agcgtagtgg ggctgccagg ccccagcttt gttccctggt    1680

ccccctgaag cctgcaaacg ttgtcatcga agggaagggt ggggggcagc tgcggtgggg    1740

agctataaaa atgacaatta aaagagacac tagtctttta tttctaaaaa aaaaaaaaaa    1800

a                                                                    1801


<210> 155
<211> 412
<212> PRT
<213> Homo sapiens

<220> 
<223> ASS1 (argininosuccinate synthase 1)

<400> 155
Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp 
1               5                   10                  15      
Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile 
            20                  25                  30          
Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg 
        35                  40                  45              
Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val 
    50                  55                  60                  
Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser 
65                  70                  75                  80  
Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro 
                85                  90                  95      
Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys 
            100                 105                 110         
Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe 
        115                 120                 125             
Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro 
    130                 135                 140                 
Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu 
145                 150                 155                 160 
Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys 
                165                 170                 175     
Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala 
            180                 185                 190         
Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr 
        195                 200                 205             
Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu 
    210                 215                 220                 
Ile Glu Phe Lys Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp 
225                 230                 235                 240 
Gly Thr Thr His Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu 
                245                 250                 255     
Val Ala Gly Lys His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg 
            260                 265                 270         
Phe Ile Gly Met Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr 
        275                 280                 285             
Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg 
    290                 295                 300                 
Glu Val Arg Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu 
305                 310                 315                 320 
Val Tyr Thr Gly Phe Trp His Ser Pro Glu Cys Glu Phe Val Arg His 
                325                 330                 335     
Cys Ile Ala Lys Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser 
            340                 345                 350         
Val Leu Lys Gly Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser 
        355                 360                 365             
Leu Tyr Asn Glu Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu 
    370                 375                 380                 
Pro Thr Asp Ala Thr Gly Phe Ile Asn Ile Asn Ser Leu Arg Leu Lys 
385                 390                 395                 400 
Glu Tyr His Arg Leu Gln Ser Lys Val Thr Ala Lys 
                405                 410         

<210> 156
<211> 8305
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..8305
<223> /mol_type="unassigned DNA"
      /note="CSPG4 (chondroitin sulfate proteoglycan 4)"
      /organism="Homo sapiens"

<400> 156
gcgcccagga gcagagccgc gctcgctcca ctcagctccc agctcccagg actccgctgg       60

ctcctcgcaa gtcctgccgc ccagcccgcc gggatgcagt ccgggccgcg gcccccactt      120

ccagcccccg gcctggcctt ggctttgacc ctgactatgt tggccagact tgcatccgcg      180

gcttccttct tcggtgagaa ccacctggag gtgcctgtgg ccacggctct gaccgacata      240

gacctgcagc tgcagttctc cacgtcccag cccgaagccc tccttctcct ggcagcaggc      300

ccagctgacc acctcctgct gcagctctac tctggacgcc tgcaggtcag acttgttctg      360

ggccaggagg agctgaggct gcagactcca gcagagacgc tgctgagtga ctccatcccc      420

cacactgtgg tgctgactgt cgtagagggc tgggccacgt tgtcagtcga tgggtttctg      480

aacgcctcct cagcagtccc aggagccccc ctagaggtcc cctatgggct ctttgttggg      540

ggcactggga cccttggcct gccctacctg aggggaacca gccgacccct gaggggttgc      600

ctccatgcag ccaccctcaa tggccgcagc ctcctccggc ctctgacccc cgatgtgcat      660

gagggctgtg ctgaagagtt ttctgccagt gatgatgtgg ccctgggctt ctctgggccc      720

cactctctgg ctgccttccc tgcctggggc actcaggacg aaggaaccct agagtttaca      780

ctcaccacac agagccggca ggcacccttg gccttccagg cagggggccg gcgtggggac      840

ttcatctatg tggacatatt tgagggccac ctgcgggccg tggtggagaa gggccagggt      900

accgtattgc tccacaacag tgtgcctgtg gccgatgggc agccccatga ggtcagtgtc      960

cacatcaatg ctcaccggct ggaaatctcc gtggaccagt accctacgca tacttcgaac     1020

cgaggagtcc tcagctacct ggagccacgg ggcagtctcc ttctcggggg gctggatgca     1080

gaggcctctc gtcacctcca ggaacaccgc ctgggcctga caccagaggc caccaatgcc     1140

tccctgctgg gctgcatgga agacctcagt gtcaatggcc agaggcgggg gctgcgggaa     1200

gctttgctga cgcgcaacat ggcagccggc tgcaggctgg aggaggagga gtatgaggac     1260

gatgcctatg gacattatga agctttctcc accctggccc ctgaggcttg gccagccatg     1320

gagctgcctg agccatgcgt gcctgagcca gggctgcctc ctgtctttgc caatttcacc     1380

cagctgctga ctatcagccc actggtggtg gccgaggggg gcacagcctg gcttgagtgg     1440

aggcatgtgc agcccacgct ggacctgatg gaggctgagc tgcgcaaatc ccaggtgctg     1500

ttcagcgtga cccgaggggc acgccatggc gagctcgagc tggacatccc gggagcccag     1560

gcacgaaaaa tgttcaccct cctggacgtg gtgaaccgca aggcccgctt catccacgat     1620

ggctctgagg acacctccga ccagctggtg ctggaggtgt cggtgacggc tcgggtgccc     1680

atgccctcat gccttcggag gggccaaaca tacctcctgc ccatccaggt caaccctgtc     1740

aatgacccac cccacatcat cttcccacat ggcagcctca tggtgatcct ggaacacacg     1800

cagaagccgc tggggcctga ggttttccag gcctatgacc cggactctgc ctgtgagggc     1860

ctcaccttcc aggtccttgg cacctcctct ggcctccccg tggagcgccg agaccagcct     1920

ggggagccgg cgaccgagtt ctcctgccgg gagttggagg ccggcagcct agtctatgtc     1980

caccgcggtg gtcctgcaca ggacttgacg ttccgggtca gcgatggact gcaggccagc     2040

cccccggcca cgctgaaggt ggtggccatc cggccggcca tacagatcca ccgcagcaca     2100

gggttgcgac tggcccaagg ctctgccatg cccatcttgc ccgccaacct gtcggtggag     2160

accaatgccg tggggcagga tgtgagcgtg ctgttccgcg tcactggggc cctgcagttt     2220

ggggagctgc agaagcaggg ggcaggtggg gtggagggtg ctgagtggtg ggccacacag     2280

gcgttccacc agcgggatgt ggagcagggc cgcgtgaggt acctgagcac tgacccacag     2340

caccacgctt acgacaccgt ggagaacctg gccctggagg tgcaggtggg ccaggagatc     2400

ctgagcaatc tgtccttccc agtgaccatc cagagagcca ctgtgtggat gctgcggctg     2460

gagccactgc acactcagaa cacccagcag gagaccctca ccacagccca cctggaggcc     2520

accctggagg aggcaggccc aagcccccca accttccatt atgaggtggt tcaggctccc     2580

aggaaaggca accttcaact acagggcaca aggctgtcag atggccaggg cttcacccag     2640

gatgacatac aggctggccg ggtgacctat ggggccacag cacgtgcctc agaggcagtc     2700

gaggacacct tccgtttccg tgtcacagct ccaccatatt tctccccact ctataccttc     2760

cccatccaca ttggtggtga cccagatgcg cctgtcctca ccaatgtcct cctcgtggtg     2820

cctgagggtg gtgagggtgt cctctctgct gaccacctct ttgtcaagag tctcaacagt     2880

gccagctacc tctatgaggt catggagcgg ccccgccatg ggaggttggc ttggcgtggg     2940

acacaggaca agaccactat ggtgacatcc ttcaccaatg aagacctgtt gcgtggccgg     3000

ctggtctacc agcatgatga ctccgagacc acagaagatg atatcccatt tgttgctacc     3060

cgccagggcg agagcagtgg tgacatggcc tgggaggagg tacggggtgt cttccgagtg     3120

gccatccagc ccgtgaatga ccacgcccct gtgcagacca tcagccggat cttccatgtg     3180

gcccggggtg ggcggcggct gctgactaca gacgacgtgg ccttcagcga tgctgactcg     3240

ggctttgctg acgcccagct ggtgcttacc cgcaaggacc tcctctttgg cagtatcgtg     3300

gccgtagatg agcccacgcg gcccatctac cgcttcaccc aggaggacct caggaagagg     3360

cgagtactgt tcgtgcactc aggggctgac cgtggctgga tccagctgca ggtgtccgac     3420

gggcaacacc aggccactgc gctgctggag gtgcaggcct cggaacccta cctccgtgtg     3480

gccaacggct ccagccttgt ggtccctcaa ggaggccagg gcaccatcga cacggccgtg     3540

ctccacctgg acaccaacct cgacatccgc agtggggatg aggtccacta ccacgtcaca     3600

gctggccctc gctggggaca gctagtccgg gctggtcagc cagccacagc cttctcccag     3660

caggacctgc tggatggggc cgttctctat agccacaatg gcagcctcag cccccgcgac     3720

accatggcct tctccgtgga agcagggcca gtgcacacgg atgccaccct acaagtgacc     3780

attgccctag agggcccact ggccccactg aagctggtcc ggcacaagaa gatctacgtc     3840

ttccagggag aggcagctga gatcagaagg gaccagctgg aggcagccca ggaggcagtg     3900

ccacctgcag acatcgtatt ctcagtgaag agcccaccga gtgccggcta cctggtgatg     3960

gtgtcgcgtg gcgccttggc agatgagcca cccagcctgg accctgtgca gagcttctcc     4020

caggaggcag tggacacagg cagggtcctg tacctgcact cccgccctga ggcctggagc     4080

gatgccttct cgctggatgt ggcctcaggc ctgggtgctc ccctcgaggg cgtccttgtg     4140

gagctggagg tgctgcccgc tgccatccca ctagaggcgc aaaacttcag cgtccctgag     4200

ggtggcagcc tcaccctggc ccctccactg ctccgtgtct ccgggcccta cttccccact     4260

ctcctgggcc tcagcctgca ggtgctggag ccaccccagc atggagccct gcagaaggag     4320

gacggacctc aagccaggac cctcagcgcc ttctcctgga gaatggtgga agagcagctg     4380

atccgctacg tgcatgacgg gagcgagaca ctgacagaca gttttgtcct gatggctaat     4440

gcctccgaga tggatcgcca gagccatcct gtggccttca ctgtcactgt cctgcctgtc     4500

aatgaccaac cccccatcct cactacaaac acaggcctgc agatgtggga gggggccact     4560

gcgcccatcc ctgcggaggc tctgaggagc acggacggcg actctgggtc tgaggatctg     4620

gtctacacca tcgagcagcc cagcaacggg cgggtagtgc tgcggggggc gccgggcact     4680

gaggtgcgca gcttcacgca ggcccagctg gacggcgggc tcgtgctgtt ctcacacaga     4740

ggaaccctgg atggaggctt ccgcttccgc ctctctgacg gcgagcacac ttcccccgga     4800

cacttcttcc gagtgacggc ccagaagcaa gtgctcctct cgctgaaggg cagccagaca     4860

ctgactgtct gcccagggtc cgtccagcca ctcagcagtc agaccctcag ggccagctcc     4920

agcgcaggca ctgaccccca gctcctgctc taccgtgtgg tgcggggccc ccagctaggc     4980

cggctgttcc acgcccagca ggacagcaca ggggaggccc tggtgaactt cactcaggca     5040

gaggtctacg ctgggaatat tctgtatgag catgagatgc cccccgagcc cttttgggag     5100

gcccatgata ccctagagct ccagctgtcc tcgccgcctg cccgggacgt ggccgccacc     5160

cttgctgtgg ctgtgtcttt tgaggctgcc tgtccccagc gccccagcca cctctggaag     5220

aacaaaggtc tctgggtccc cgagggccag cgggccagga tcaccgtggc tgctctggat     5280

gcctccaatc tcttggccag cgttccatca ccccagcgct cagagcatga tgtgctcttc     5340

caggtcacac agttccccag ccggggccag ctgttggtgt ccgaggagcc cctccatgct     5400

gggcagcccc acttcctgca gtcccagctg gctgcagggc agctagtgta tgcccacggc     5460

ggtgggggca cccagcagga tggcttccac tttcgtgccc acctccaggg gccagcaggg     5520

gcctccgtgg ctggacccca aacctcagag gcctttgcca tcacggtgag ggatgtaaat     5580

gagcggcccc ctcagccaca ggcctctgtc ccactccggc tcacccgagg ctctcgtgcc     5640

cccatctccc gggcccagct gagtgtggtg gacccagact cagctcctgg ggagattgag     5700

tacgaggtcc agcgggcacc ccacaacggc ttcctcagcc tggtgggtgg tggcctgggg     5760

cccgtgaccc gcttcacgca agccgatgtg gattcagggc ggctggcctt cgtggccaac     5820

gggagcagcg tggcaggcat cttccagctg agcatgtctg atggggccag cccacccctg     5880

cccatgtccc tggctgtgga catcctacca tccgccatcg aggtgcagct gcgggcaccc     5940

ctggaggtgc cccaagcttt ggggcgctcc tcactgagcc agcagcagct ccgggtggtt     6000

tcagatcggg aggagccaga ggcagcatac cgcctcatcc agggacccca gtatgggcat     6060

ctcctggtgg gcgggcggcc cacctcggcc ttcagccaat tccagataga ccagggcgag     6120

gtggtctttg ccttcaccaa cttctcctcc tctcatgacc acttcagagt cctggcactg     6180

gctaggggtg tcaatgcatc agccgtagtg aacgtcactg tgagggctct gctgcatgtg     6240

tgggcaggtg ggccatggcc ccagggtgcc accctgcgcc tggaccccac cgtcctagat     6300

gctggcgagc tggccaaccg cacaggcagt gtgccgcgct tccgcctcct ggagggaccc     6360

cggcatggcc gcgtggtccg cgtgccccga gccaggacgg agcccggggg cagccagctg     6420

gtggagcagt tcactcagca ggaccttgag gacgggaggc tggggctgga ggtgggcagg     6480

ccagagggga gggcccccgg ccccgcaggt gacagtctca ctctggagct gtgggcacag     6540

ggcgtcccgc ctgctgtggc ctccctggac tttgccactg agccttacaa tgctgcccgg     6600

ccctacagcg tggccctgct cagtgtcccc gaggccgccc ggacggaagc agggaagcca     6660

gagagcagca cccccacagg cgagccaggc cccatggcat ccagccctga gcccgctgtg     6720

gccaagggag gcttcctgag cttccttgag gccaacatgt tcagcgtcat catccccatg     6780

tgcctggtac ttctgctcct ggcgctcatc ctgcccctgc tcttctacct ccgaaaacgc     6840

aacaagacgg gcaagcatga cgtccaggtc ctgactgcca agccccgcaa cggcctggct     6900

ggtgacaccg agacctttcg caaggtggag ccaggccagg ccatcccgct cacagctgtg     6960

cctggccagg ggccccctcc aggaggccag cctgacccag agctgctgca gttctgccgg     7020

acacccaacc ctgcccttaa gaatggccag tactgggtgt gaggcctggc ctgggcccag     7080

atgctgatcg ggccagggac aggcttgccc atgtcccggg ccccattgct tccatgcctg     7140

gtgctgtctg agtatcccca gagcaagaga gacctggaga caccaggggt ggagggtcct     7200

gggagatagt cccaggggtc cgggacagag tggagtcaag agctggaacc tccctcagct     7260

cactccgagc ctggagaact gcaggggcca aggtggaggc aggcttaagt tcagtcctcc     7320

tgccctggag ctggtttggg ctgtcaaaac cagggtaacc tcctacatgg gtcatgactc     7380

tgggtcctgg gtctgtgacc ttgggtaagt cgcgcctgac ccaggctgct aagagggcaa     7440

ggagaaggaa gtaccctggg gagggaaggg acagaggaag ctattcctgg cttttccact     7500

ccaacccagg ccaccctttg tctctgcccc agagttgaga aaaaaacttc ctcccctggt     7560

tttttaggga gatggtatcc cctggagtag agggcaagag gagagagcgc ctccagtcta     7620

gaaggcataa gccaatagga taatatattc agggtgcagg gtgggtaggt tgctctgggg     7680

atgggtttat ttaagggaga ttgcaaggaa gctatttaac atggtgctga gctagccagg     7740

actgatggag cccctggggg tgtgggatgg aggagggtct gcagccagtt cattcccagg     7800

gccccatctt gatgggccaa gggctaaaca tgcatgtgtc agtggctttg gagcaggtta     7860

ggctggggct catcgagggt ctcaggccga ggccactgcg gtgccagtgc ccccctgagg     7920

actagggcag gcagctgggg gcacttggtt ccatggagcc tggataaaca gtgctttgga     7980

ggctctggac agctgtgtgg tgtttgtgtc ttaactatgc actgggccct tgtctgcgtc     8040

ggcttgcata cagagggccc ctggggtcgg ccctccggcc tggcctcagc cagtgggatg     8100

gacagggcca ggcaggcctc tgaacttcca cctcctgggg cctcccagac ctcctgtgcc     8160

cccacctgtg tgggcaggtg ggccagtctt cgggtgatgg gaccaaaccc cttcagttca     8220

gtagagaaag gctaggtcct ctacaaagag ctgcaagaca aaaattaaaa taaatgctcc     8280

ccaccctaga aaaaaaaaaa aaaaa                                           8305


<210> 157
<211> 2322
<212> PRT
<213> Homo sapiens

<220> 
<223> CSPG4 (chondroitin sulfate proteoglycan 4)

<400> 157
Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      
Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          
Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              
Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  
Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  
Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      
Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         
Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             
Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 
Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 
Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     
Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         
Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             
Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 
Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 
Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     
Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         
Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             
Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 
Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 
Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     
Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         
Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             
Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 
Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 
Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     
Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         
Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             
Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 
Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 
Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     
Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         
Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             
Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 
Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 
Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     
Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         
Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             
Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 
Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 
Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     
Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         
Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             
Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 
Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 
Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     
Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         
Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             
Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 
Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 
Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     
Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         
Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             
Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 
Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 
Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     
Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         
Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             
Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 
Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 
Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     
Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         
Glu Ser Ser Gly Asp Met Ala Trp Glu Glu Val Arg Gly Val Phe Arg 
        995                 1000                1005            
Val Ala Ile Gln Pro Val Asn Asp His Ala Pro Val Gln Thr Ile Ser 
    1010                1015                1020                
Arg Ile Phe His Val Ala Arg Gly Gly Arg Arg Leu Leu Thr Thr Asp 
1025                1030                1035                1040
Asp Val Ala Phe Ser Asp Ala Asp Ser Gly Phe Ala Asp Ala Gln Leu 
                1045                1050                1055    
Val Leu Thr Arg Lys Asp Leu Leu Phe Gly Ser Ile Val Ala Val Asp 
            1060                1065                1070        
Glu Pro Thr Arg Pro Ile Tyr Arg Phe Thr Gln Glu Asp Leu Arg Lys 
        1075                1080                1085            
Arg Arg Val Leu Phe Val His Ser Gly Ala Asp Arg Gly Trp Ile Gln 
    1090                1095                1100                
Leu Gln Val Ser Asp Gly Gln His Gln Ala Thr Ala Leu Leu Glu Val 
1105                1110                1115                1120
Gln Ala Ser Glu Pro Tyr Leu Arg Val Ala Asn Gly Ser Ser Leu Val 
                1125                1130                1135    
Val Pro Gln Gly Gly Gln Gly Thr Ile Asp Thr Ala Val Leu His Leu 
            1140                1145                1150        
Asp Thr Asn Leu Asp Ile Arg Ser Gly Asp Glu Val His Tyr His Val 
        1155                1160                1165            
Thr Ala Gly Pro Arg Trp Gly Gln Leu Val Arg Ala Gly Gln Pro Ala 
    1170                1175                1180                
Thr Ala Phe Ser Gln Gln Asp Leu Leu Asp Gly Ala Val Leu Tyr Ser 
1185                1190                1195                1200
His Asn Gly Ser Leu Ser Pro Arg Asp Thr Met Ala Phe Ser Val Glu 
                1205                1210                1215    
Ala Gly Pro Val His Thr Asp Ala Thr Leu Gln Val Thr Ile Ala Leu 
            1220                1225                1230        
Glu Gly Pro Leu Ala Pro Leu Lys Leu Val Arg His Lys Lys Ile Tyr 
        1235                1240                1245            
Val Phe Gln Gly Glu Ala Ala Glu Ile Arg Arg Asp Gln Leu Glu Ala 
    1250                1255                1260                
Ala Gln Glu Ala Val Pro Pro Ala Asp Ile Val Phe Ser Val Lys Ser 
1265                1270                1275                1280
Pro Pro Ser Ala Gly Tyr Leu Val Met Val Ser Arg Gly Ala Leu Ala 
                1285                1290                1295    
Asp Glu Pro Pro Ser Leu Asp Pro Val Gln Ser Phe Ser Gln Glu Ala 
            1300                1305                1310        
Val Asp Thr Gly Arg Val Leu Tyr Leu His Ser Arg Pro Glu Ala Trp 
        1315                1320                1325            
Ser Asp Ala Phe Ser Leu Asp Val Ala Ser Gly Leu Gly Ala Pro Leu 
    1330                1335                1340                
Glu Gly Val Leu Val Glu Leu Glu Val Leu Pro Ala Ala Ile Pro Leu 
1345                1350                1355                1360
Glu Ala Gln Asn Phe Ser Val Pro Glu Gly Gly Ser Leu Thr Leu Ala 
                1365                1370                1375    
Pro Pro Leu Leu Arg Val Ser Gly Pro Tyr Phe Pro Thr Leu Leu Gly 
            1380                1385                1390        
Leu Ser Leu Gln Val Leu Glu Pro Pro Gln His Gly Ala Leu Gln Lys 
        1395                1400                1405            
Glu Asp Gly Pro Gln Ala Arg Thr Leu Ser Ala Phe Ser Trp Arg Met 
    1410                1415                1420                
Val Glu Glu Gln Leu Ile Arg Tyr Val His Asp Gly Ser Glu Thr Leu 
1425                1430                1435                1440
Thr Asp Ser Phe Val Leu Met Ala Asn Ala Ser Glu Met Asp Arg Gln 
                1445                1450                1455    
Ser His Pro Val Ala Phe Thr Val Thr Val Leu Pro Val Asn Asp Gln 
            1460                1465                1470        
Pro Pro Ile Leu Thr Thr Asn Thr Gly Leu Gln Met Trp Glu Gly Ala 
        1475                1480                1485            
Thr Ala Pro Ile Pro Ala Glu Ala Leu Arg Ser Thr Asp Gly Asp Ser 
    1490                1495                1500                
Gly Ser Glu Asp Leu Val Tyr Thr Ile Glu Gln Pro Ser Asn Gly Arg 
1505                1510                1515                1520
Val Val Leu Arg Gly Ala Pro Gly Thr Glu Val Arg Ser Phe Thr Gln 
                1525                1530                1535    
Ala Gln Leu Asp Gly Gly Leu Val Leu Phe Ser His Arg Gly Thr Leu 
            1540                1545                1550        
Asp Gly Gly Phe Arg Phe Arg Leu Ser Asp Gly Glu His Thr Ser Pro 
        1555                1560                1565            
Gly His Phe Phe Arg Val Thr Ala Gln Lys Gln Val Leu Leu Ser Leu 
    1570                1575                1580                
Lys Gly Ser Gln Thr Leu Thr Val Cys Pro Gly Ser Val Gln Pro Leu 
1585                1590                1595                1600
Ser Ser Gln Thr Leu Arg Ala Ser Ser Ser Ala Gly Thr Asp Pro Gln 
                1605                1610                1615    
Leu Leu Leu Tyr Arg Val Val Arg Gly Pro Gln Leu Gly Arg Leu Phe 
            1620                1625                1630        
His Ala Gln Gln Asp Ser Thr Gly Glu Ala Leu Val Asn Phe Thr Gln 
        1635                1640                1645            
Ala Glu Val Tyr Ala Gly Asn Ile Leu Tyr Glu His Glu Met Pro Pro 
    1650                1655                1660                
Glu Pro Phe Trp Glu Ala His Asp Thr Leu Glu Leu Gln Leu Ser Ser 
1665                1670                1675                1680
Pro Pro Ala Arg Asp Val Ala Ala Thr Leu Ala Val Ala Val Ser Phe 
                1685                1690                1695    
Glu Ala Ala Cys Pro Gln Arg Pro Ser His Leu Trp Lys Asn Lys Gly 
            1700                1705                1710        
Leu Trp Val Pro Glu Gly Gln Arg Ala Arg Ile Thr Val Ala Ala Leu 
        1715                1720                1725            
Asp Ala Ser Asn Leu Leu Ala Ser Val Pro Ser Pro Gln Arg Ser Glu 
    1730                1735                1740                
His Asp Val Leu Phe Gln Val Thr Gln Phe Pro Ser Arg Gly Gln Leu 
1745                1750                1755                1760
Leu Val Ser Glu Glu Pro Leu His Ala Gly Gln Pro His Phe Leu Gln 
                1765                1770                1775    
Ser Gln Leu Ala Ala Gly Gln Leu Val Tyr Ala His Gly Gly Gly Gly 
            1780                1785                1790        
Thr Gln Gln Asp Gly Phe His Phe Arg Ala His Leu Gln Gly Pro Ala 
        1795                1800                1805            
Gly Ala Ser Val Ala Gly Pro Gln Thr Ser Glu Ala Phe Ala Ile Thr 
    1810                1815                1820                
Val Arg Asp Val Asn Glu Arg Pro Pro Gln Pro Gln Ala Ser Val Pro 
1825                1830                1835                1840
Leu Arg Leu Thr Arg Gly Ser Arg Ala Pro Ile Ser Arg Ala Gln Leu 
                1845                1850                1855    
Ser Val Val Asp Pro Asp Ser Ala Pro Gly Glu Ile Glu Tyr Glu Val 
            1860                1865                1870        
Gln Arg Ala Pro His Asn Gly Phe Leu Ser Leu Val Gly Gly Gly Leu 
        1875                1880                1885            
Gly Pro Val Thr Arg Phe Thr Gln Ala Asp Val Asp Ser Gly Arg Leu 
    1890                1895                1900                
Ala Phe Val Ala Asn Gly Ser Ser Val Ala Gly Ile Phe Gln Leu Ser 
1905                1910                1915                1920
Met Ser Asp Gly Ala Ser Pro Pro Leu Pro Met Ser Leu Ala Val Asp 
                1925                1930                1935    
Ile Leu Pro Ser Ala Ile Glu Val Gln Leu Arg Ala Pro Leu Glu Val 
            1940                1945                1950        
Pro Gln Ala Leu Gly Arg Ser Ser Leu Ser Gln Gln Gln Leu Arg Val 
        1955                1960                1965            
Val Ser Asp Arg Glu Glu Pro Glu Ala Ala Tyr Arg Leu Ile Gln Gly 
    1970                1975                1980                
Pro Gln Tyr Gly His Leu Leu Val Gly Gly Arg Pro Thr Ser Ala Phe 
1985                1990                1995                2000
Ser Gln Phe Gln Ile Asp Gln Gly Glu Val Val Phe Ala Phe Thr Asn 
                2005                2010                2015    
Phe Ser Ser Ser His Asp His Phe Arg Val Leu Ala Leu Ala Arg Gly 
            2020                2025                2030        
Val Asn Ala Ser Ala Val Val Asn Val Thr Val Arg Ala Leu Leu His 
        2035                2040                2045            
Val Trp Ala Gly Gly Pro Trp Pro Gln Gly Ala Thr Leu Arg Leu Asp 
    2050                2055                2060                
Pro Thr Val Leu Asp Ala Gly Glu Leu Ala Asn Arg Thr Gly Ser Val 
2065                2070                2075                2080
Pro Arg Phe Arg Leu Leu Glu Gly Pro Arg His Gly Arg Val Val Arg 
                2085                2090                2095    
Val Pro Arg Ala Arg Thr Glu Pro Gly Gly Ser Gln Leu Val Glu Gln 
            2100                2105                2110        
Phe Thr Gln Gln Asp Leu Glu Asp Gly Arg Leu Gly Leu Glu Val Gly 
        2115                2120                2125            
Arg Pro Glu Gly Arg Ala Pro Gly Pro Ala Gly Asp Ser Leu Thr Leu 
    2130                2135                2140                
Glu Leu Trp Ala Gln Gly Val Pro Pro Ala Val Ala Ser Leu Asp Phe 
2145                2150                2155                2160
Ala Thr Glu Pro Tyr Asn Ala Ala Arg Pro Tyr Ser Val Ala Leu Leu 
                2165                2170                2175    
Ser Val Pro Glu Ala Ala Arg Thr Glu Ala Gly Lys Pro Glu Ser Ser 
            2180                2185                2190        
Thr Pro Thr Gly Glu Pro Gly Pro Met Ala Ser Ser Pro Glu Pro Ala 
        2195                2200                2205            
Val Ala Lys Gly Gly Phe Leu Ser Phe Leu Glu Ala Asn Met Phe Ser 
    2210                2215                2220                
Val Ile Ile Pro Met Cys Leu Val Leu Leu Leu Leu Ala Leu Ile Leu 
2225                2230                2235                2240
Pro Leu Leu Phe Tyr Leu Arg Lys Arg Asn Lys Thr Gly Lys His Asp 
                2245                2250                2255    
Val Gln Val Leu Thr Ala Lys Pro Arg Asn Gly Leu Ala Gly Asp Thr 
            2260                2265                2270        
Glu Thr Phe Arg Lys Val Glu Pro Gly Gln Ala Ile Pro Leu Thr Ala 
        2275                2280                2285            
Val Pro Gly Gln Gly Pro Pro Pro Gly Gly Gln Pro Asp Pro Glu Leu 
    2290                2295                2300                
Leu Gln Phe Cys Arg Thr Pro Asn Pro Ala Leu Lys Asn Gly Gln Tyr 
2305                2310                2315                2320
Trp Val 
        

<210> 158
<211> 3654
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3654
<223> /mol_type="unassigned DNA"
      /note="CDH11 (cadherin 11, type 2, OB-cadherin)"
      /organism="Homo sapiens"

<400> 158
agatgccgcg ggggccgctc gcagccgccg ctgacttgtg aatgggaccg ggactggggc       60

cgggactgac accgcagcgc ttgccctgcg ccagggactg gcggctcgga ggttgcgtcc      120

accctcaagg gccccagaaa tcactgtgtt ttcagctcag cggccctgtg acattccttc      180

gtgttgtcat ttgttgagtg accaatcaga tgggtggagt gtgttacaga aattggcagc      240

aagtatccaa tgggtgaaga agaagctaac tggggacgtg ggcagccctg acgtgatgag      300

ctcaaccagc agagacattc catcccaaga gaggtctgcg tgacgcgtcc gggaggccac      360

cctcagcaag accaccgtac agttggtgga aggggtgaca gctgcattct cctgtgccta      420

ccacgtaacc aaaaatgaag gagaactact gtttacaagc cgccctggtg tgcctgggca      480

tgctgtgcca cagccatgcc tttgccccag agcggcgggg gcacctgcgg ccctccttcc      540

atgggcacca tgagaagggc aaggaggggc aggtgctaca gcgctccaag cgtggctggg      600

tctggaacca gttcttcgtg atagaggagt acaccgggcc tgaccccgtg cttgtgggca      660

ggcttcattc agatattgac tctggtgatg ggaacattaa atacattctc tcaggggaag      720

gagctggaac catttttgtg attgatgaca aatcagggaa cattcatgcc accaagacgt      780

tggatcgaga agagagagcc cagtacacgt tgatggctca ggcggtggac agggacacca      840

atcggccact ggagccaccg tcggaattca ttgtcaaggt ccaggacatt aatgacaacc      900

ctccggagtt cctgcacgag acctatcatg ccaacgtgcc tgagaggtcc aatgtgggaa      960

cgtcagtaat ccaggtgaca gcttcagatg cagatgaccc cacttatgga aatagcgcca     1020

agttagtgta cagtatcctc gaaggacaac cctatttttc ggtggaagca cagacaggta     1080

tcatcagaac agccctaccc aacatggaca gggaggccaa ggaggagtac cacgtggtga     1140

tccaggccaa ggacatgggt ggacatatgg gcggactctc agggacaacc aaagtgacga     1200

tcacactgac cgatgtcaat gacaacccac caaagtttcc gcagagcgta taccagatgt     1260

ctgtgtcaga agcagccgtc cctggggagg aagtaggaag agtgaaagct aaagatccag     1320

acattggaga aaatggctta gtcacataca atattgttga tggagatggt atggaatcgt     1380

ttgaaatcac aacggactat gaaacacagg agggggtgat aaagctgaaa aagcctgtag     1440

attttgaaac caaaagagcc tatagcttga aggtagaggc agccaacgtg cacatcgacc     1500

cgaagtttat cagcaatggc cctttcaagg acactgtgac cgtcaagatc tcagtagaag     1560

atgctgatga gccccctatg ttcttggccc caagttacat ccacgaagtc caagaaaatg     1620

cagctgctgg caccgtggtt gggagagtgc atgccaaaga ccctgatgct gccaacagcc     1680

cgataaggta ttccatcgat cgtcacactg acctcgacag atttttcact attaatccag     1740

aggatggttt tattaaaact acaaaacctc tggatagaga ggaaacagcc tggctcaaca     1800

tcactgtctt tgcagcagaa atccacaatc ggcatcagga agccaaagtc ccagtggcca     1860

ttagggtcct tgatgtcaac gataatgctc ccaagtttgc tgccccttat gaaggtttca     1920

tctgtgagag tgatcagacc aagccacttt ccaaccagcc aattgttaca attagtgcag     1980

atgacaagga tgacacggcc aatggaccaa gatttatctt cagcctaccc cctgaaatca     2040

ttcacaatcc aaatttcaca gtcagagaca accgagataa cacagcaggc gtgtacgccc     2100

ggcgtggagg gttcagtcgg cagaagcagg acttgtacct tctgcccata gtgatcagcg     2160

atggcggcat cccgcccatg agtagcacca acaccctcac catcaaagtc tgcgggtgcg     2220

acgtgaacgg ggcactgctc tcctgcaacg cagaggccta cattctgaac gccggcctga     2280

gcacaggcgc cctgatcgcc atcctcgcct gcatcgtcat tctcctggtc attgtagtat     2340

tgtttgtgac cctgagaagg caaaagaaag aaccactcat tgtctttgag gaagaagatg     2400

tccgtgagaa catcattact tatgatgatg aagggggtgg ggaagaagac acagaagcct     2460

ttgatattgc caccctccag aatcctgatg gtatcaatgg atttatcccc cgcaaagaca     2520

tcaaacctga gtatcagtac atgcctagac ctgggctccg gccagcgccc aacagcgtgg     2580

atgtcgatga cttcatcaac acgagaatac aggaggcaga caatgacccc acggctcctc     2640

cttatgactc cattcaaatc tacggttatg aaggcagggg ctcagtggcc gggtccctga     2700

gctccctaga gtcggccacc acagattcag acttggacta tgattatcta cagaactggg     2760

gacctcgttt taagaaacta gcagatttgt atggttccaa agacactttt gatgacgatt     2820

cttaacaata acgatacaaa tttggcctta agaactgtgt ctggcgttct caagaatcta     2880

gaagatgtgt aaacaggtat ttttttaaat caaggaaagg ctcatttaaa acaggcaaag     2940

ttttacagag aggatacatt taataaaact gcgaggacat caaagtggta aatactgtga     3000

aatacctttt ctcacaaaaa ggcaaatatt gaagttgttt atcaacttcg ctagaaaaaa     3060

aaaacacttg gcatacaaaa tatttaagtg aaggagaagt ctaacgctga actgacaatg     3120

aagggaaatt gtttatgtgt tatgaacatc caagtctttc ttctttttta agttgtcaaa     3180

gaagcttcca caaaattaga aaggacaaca gttctgagct gtaatttcgc cttaaactct     3240

ggacactcta tatgtagtgc atttttaaac ttgaaatata taatattcag ccagcttaaa     3300

cccatacaat gtatgtacaa tacaatgtac aattatgtct cttgagcatc aatcttgtta     3360

ctgctgattc ttgtaaatct ttttgcttct actttcatct taaactaata cgtgccagat     3420

ataactgtct tgtttcagtg agagacgccc tatttctatg tcatttttaa tgtatctatt     3480

tgtacaattt taaagttctt attttagtat acgtataaat atcagtattc tgacatgtaa     3540

gaaaatgtta cggcatcaca cttatatttt atgaacattg tactgttgct ttaatatgag     3600

cttcaatata agaagcaatc tttgaaataa aaaaagattt ttttttaaaa aaaa           3654


<210> 159
<211> 796
<212> PRT
<213> Homo sapiens

<220> 
<223> CDH11 (cadherin 11, type 2, OB-cadherin)

<400> 159
Met Lys Glu Asn Tyr Cys Leu Gln Ala Ala Leu Val Cys Leu Gly Met 
1               5                   10                  15      
Leu Cys His Ser His Ala Phe Ala Pro Glu Arg Arg Gly His Leu Arg 
            20                  25                  30          
Pro Ser Phe His Gly His His Glu Lys Gly Lys Glu Gly Gln Val Leu 
        35                  40                  45              
Gln Arg Ser Lys Arg Gly Trp Val Trp Asn Gln Phe Phe Val Ile Glu 
    50                  55                  60                  
Glu Tyr Thr Gly Pro Asp Pro Val Leu Val Gly Arg Leu His Ser Asp 
65                  70                  75                  80  
Ile Asp Ser Gly Asp Gly Asn Ile Lys Tyr Ile Leu Ser Gly Glu Gly 
                85                  90                  95      
Ala Gly Thr Ile Phe Val Ile Asp Asp Lys Ser Gly Asn Ile His Ala 
            100                 105                 110         
Thr Lys Thr Leu Asp Arg Glu Glu Arg Ala Gln Tyr Thr Leu Met Ala 
        115                 120                 125             
Gln Ala Val Asp Arg Asp Thr Asn Arg Pro Leu Glu Pro Pro Ser Glu 
    130                 135                 140                 
Phe Ile Val Lys Val Gln Asp Ile Asn Asp Asn Pro Pro Glu Phe Leu 
145                 150                 155                 160 
His Glu Thr Tyr His Ala Asn Val Pro Glu Arg Ser Asn Val Gly Thr 
                165                 170                 175     
Ser Val Ile Gln Val Thr Ala Ser Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         
Asn Ser Ala Lys Leu Val Tyr Ser Ile Leu Glu Gly Gln Pro Tyr Phe 
        195                 200                 205             
Ser Val Glu Ala Gln Thr Gly Ile Ile Arg Thr Ala Leu Pro Asn Met 
    210                 215                 220                 
Asp Arg Glu Ala Lys Glu Glu Tyr His Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 
Met Gly Gly His Met Gly Gly Leu Ser Gly Thr Thr Lys Val Thr Ile 
                245                 250                 255     
Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Pro Gln Ser Val 
            260                 265                 270         
Tyr Gln Met Ser Val Ser Glu Ala Ala Val Pro Gly Glu Glu Val Gly 
        275                 280                 285             
Arg Val Lys Ala Lys Asp Pro Asp Ile Gly Glu Asn Gly Leu Val Thr 
    290                 295                 300                 
Tyr Asn Ile Val Asp Gly Asp Gly Met Glu Ser Phe Glu Ile Thr Thr 
305                 310                 315                 320 
Asp Tyr Glu Thr Gln Glu Gly Val Ile Lys Leu Lys Lys Pro Val Asp 
                325                 330                 335     
Phe Glu Thr Lys Arg Ala Tyr Ser Leu Lys Val Glu Ala Ala Asn Val 
            340                 345                 350         
His Ile Asp Pro Lys Phe Ile Ser Asn Gly Pro Phe Lys Asp Thr Val 
        355                 360                 365             
Thr Val Lys Ile Ser Val Glu Asp Ala Asp Glu Pro Pro Met Phe Leu 
    370                 375                 380                 
Ala Pro Ser Tyr Ile His Glu Val Gln Glu Asn Ala Ala Ala Gly Thr 
385                 390                 395                 400 
Val Val Gly Arg Val His Ala Lys Asp Pro Asp Ala Ala Asn Ser Pro 
                405                 410                 415     
Ile Arg Tyr Ser Ile Asp Arg His Thr Asp Leu Asp Arg Phe Phe Thr 
            420                 425                 430         
Ile Asn Pro Glu Asp Gly Phe Ile Lys Thr Thr Lys Pro Leu Asp Arg 
        435                 440                 445             
Glu Glu Thr Ala Trp Leu Asn Ile Thr Val Phe Ala Ala Glu Ile His 
    450                 455                 460                 
Asn Arg His Gln Glu Ala Lys Val Pro Val Ala Ile Arg Val Leu Asp 
465                 470                 475                 480 
Val Asn Asp Asn Ala Pro Lys Phe Ala Ala Pro Tyr Glu Gly Phe Ile 
                485                 490                 495     
Cys Glu Ser Asp Gln Thr Lys Pro Leu Ser Asn Gln Pro Ile Val Thr 
            500                 505                 510         
Ile Ser Ala Asp Asp Lys Asp Asp Thr Ala Asn Gly Pro Arg Phe Ile 
        515                 520                 525             
Phe Ser Leu Pro Pro Glu Ile Ile His Asn Pro Asn Phe Thr Val Arg 
    530                 535                 540                 
Asp Asn Arg Asp Asn Thr Ala Gly Val Tyr Ala Arg Arg Gly Gly Phe 
545                 550                 555                 560 
Ser Arg Gln Lys Gln Asp Leu Tyr Leu Leu Pro Ile Val Ile Ser Asp 
                565                 570                 575     
Gly Gly Ile Pro Pro Met Ser Ser Thr Asn Thr Leu Thr Ile Lys Val 
            580                 585                 590         
Cys Gly Cys Asp Val Asn Gly Ala Leu Leu Ser Cys Asn Ala Glu Ala 
        595                 600                 605             
Tyr Ile Leu Asn Ala Gly Leu Ser Thr Gly Ala Leu Ile Ala Ile Leu 
    610                 615                 620                 
Ala Cys Ile Val Ile Leu Leu Val Ile Val Val Leu Phe Val Thr Leu 
625                 630                 635                 640 
Arg Arg Gln Lys Lys Glu Pro Leu Ile Val Phe Glu Glu Glu Asp Val 
                645                 650                 655     
Arg Glu Asn Ile Ile Thr Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp 
            660                 665                 670         
Thr Glu Ala Phe Asp Ile Ala Thr Leu Gln Asn Pro Asp Gly Ile Asn 
        675                 680                 685             
Gly Phe Ile Pro Arg Lys Asp Ile Lys Pro Glu Tyr Gln Tyr Met Pro 
    690                 695                 700                 
Arg Pro Gly Leu Arg Pro Ala Pro Asn Ser Val Asp Val Asp Asp Phe 
705                 710                 715                 720 
Ile Asn Thr Arg Ile Gln Glu Ala Asp Asn Asp Pro Thr Ala Pro Pro 
                725                 730                 735     
Tyr Asp Ser Ile Gln Ile Tyr Gly Tyr Glu Gly Arg Gly Ser Val Ala 
            740                 745                 750         
Gly Ser Leu Ser Ser Leu Glu Ser Ala Thr Thr Asp Ser Asp Leu Asp 
        755                 760                 765             
Tyr Asp Tyr Leu Gln Asn Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp 
    770                 775                 780                 
Leu Tyr Gly Ser Lys Asp Thr Phe Asp Asp Asp Ser 
785                 790                 795     

