                         SEQUENCE LISTING

<110>  Amplimmune, Inc.
       LANGERMANN, SOLOMON
       PODOJIL, JOSEPH R.
       MILLER, STEPHEN D..
 
<120>  RECEPTORS FOR B7-H4

<130>  AMP 110R.NP1

<150>  61/824,860
<151>  2013-05-17

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Val Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  2
<211>  1894
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Ala Met Pro Trp Asn Trp Thr Cys Leu Leu Ser His Leu Leu 
1               5                   10                  15      


Met Val Gly Met Gly Ser Ser Thr Leu Leu Thr Arg Gln Pro Ala Pro 
            20                  25                  30          


Leu Ser Gln Lys Gln Arg Ser Phe Val Thr Phe Arg Gly Glu Pro Ala 
        35                  40                  45              


Glu Gly Phe Asn His Leu Val Val Asp Glu Arg Thr Gly His Ile Tyr 
    50                  55                  60                  


Leu Gly Ala Val Asn Arg Ile Tyr Lys Leu Ser Ser Asp Leu Lys Val 
65                  70                  75                  80  


Leu Val Thr His Glu Thr Gly Pro Asp Glu Asp Asn Pro Lys Cys Tyr 
                85                  90                  95      


Pro Pro Arg Ile Val Gln Thr Cys Asn Glu Pro Leu Thr Thr Thr Asn 
            100                 105                 110         


Asn Val Asn Lys Met Leu Leu Ile Asp Tyr Lys Glu Asn Arg Leu Ile 
        115                 120                 125             


Ala Cys Gly Ser Leu Tyr Gln Gly Ile Cys Lys Leu Leu Arg Leu Glu 
    130                 135                 140                 


Asp Leu Phe Lys Leu Gly Glu Pro Tyr His Lys Lys Glu His Tyr Leu 
145                 150                 155                 160 


Ser Gly Val Asn Glu Ser Gly Ser Val Phe Gly Val Ile Val Ser Tyr 
                165                 170                 175     


Ser Asn Leu Asp Asp Lys Leu Phe Ile Ala Thr Ala Val Asp Gly Lys 
            180                 185                 190         


Pro Glu Tyr Phe Pro Thr Ile Ser Ser Arg Lys Leu Thr Lys Asn Ser 
        195                 200                 205             


Glu Ala Asp Gly Met Phe Ala Tyr Val Phe His Asp Glu Phe Val Ala 
    210                 215                 220                 


Ser Met Ile Lys Ile Pro Ser Asp Thr Phe Thr Ile Ile Pro Asp Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Val Tyr Gly Phe Ser Ser Gly Asn Phe Val Tyr Phe 
                245                 250                 255     


Leu Thr Leu Gln Pro Glu Met Val Ser Pro Pro Gly Ser Thr Thr Lys 
            260                 265                 270         


Glu Gln Val Tyr Thr Ser Lys Leu Val Arg Leu Cys Lys Glu Asp Thr 
        275                 280                 285             


Ala Phe Asn Ser Tyr Val Glu Val Pro Ile Gly Cys Glu Arg Ser Gly 
    290                 295                 300                 


Val Glu Tyr Arg Leu Leu Gln Ala Ala Tyr Leu Ser Lys Ala Gly Ala 
305                 310                 315                 320 


Val Leu Gly Arg Thr Leu Gly Val His Pro Asp Asp Asp Leu Leu Phe 
                325                 330                 335     


Thr Val Phe Ser Lys Gly Gln Lys Arg Lys Met Lys Ser Leu Asp Glu 
            340                 345                 350         


Ser Ala Leu Cys Ile Phe Ile Leu Lys Gln Ile Asn Asp Arg Ile Lys 
        355                 360                 365             


Glu Arg Leu Gln Ser Cys Tyr Arg Gly Glu Gly Thr Leu Asp Leu Ala 
    370                 375                 380                 


Trp Leu Lys Val Lys Asp Ile Pro Cys Ser Ser Ala Leu Leu Thr Ile 
385                 390                 395                 400 


Asp Asp Asn Phe Cys Gly Leu Asp Met Asn Ala Pro Leu Gly Val Ser 
                405                 410                 415     


Asp Met Val Arg Gly Ile Pro Val Phe Thr Glu Asp Arg Asp Arg Met 
            420                 425                 430         


Thr Ser Val Ile Ala Tyr Val Tyr Lys Asn His Ser Leu Ala Phe Val 
        435                 440                 445             


Gly Thr Lys Ser Gly Lys Leu Lys Lys Ile Arg Val Asp Gly Pro Arg 
    450                 455                 460                 


Gly Asn Ala Leu Gln Tyr Glu Thr Val Gln Val Val Asp Pro Gly Pro 
465                 470                 475                 480 


Val Leu Arg Asp Met Ala Phe Ser Lys Asp His Glu Gln Leu Tyr Ile 
                485                 490                 495     


Met Ser Glu Arg Gln Leu Thr Arg Val Pro Val Glu Ser Cys Gly Gln 
            500                 505                 510         


Tyr Gln Ser Cys Gly Glu Cys Leu Gly Ser Gly Asp Pro His Cys Gly 
        515                 520                 525             


Trp Cys Val Leu His Asn Thr Cys Thr Arg Lys Glu Arg Cys Glu Arg 
    530                 535                 540                 


Ser Lys Glu Pro Arg Arg Phe Ala Ser Glu Met Lys Gln Cys Val Arg 
545                 550                 555                 560 


Leu Thr Val His Pro Asn Asn Ile Ser Val Ser Gln Tyr Asn Val Leu 
                565                 570                 575     


Leu Val Leu Glu Thr Tyr Asn Val Pro Glu Leu Ser Ala Gly Val Asn 
            580                 585                 590         


Cys Thr Phe Glu Asp Leu Ser Glu Met Asp Gly Leu Val Val Gly Asn 
        595                 600                 605             


Gln Ile Gln Cys Tyr Ser Pro Ala Ala Lys Glu Val Pro Arg Ile Ile 
    610                 615                 620                 


Thr Glu Asn Gly Asp His His Val Val Gln Leu Gln Leu Lys Ser Lys 
625                 630                 635                 640 


Glu Thr Gly Met Thr Phe Ala Ser Thr Ser Phe Val Phe Tyr Asn Cys 
                645                 650                 655     


Ser Val His Asn Ser Cys Leu Ser Cys Val Glu Ser Pro Tyr Arg Cys 
            660                 665                 670         


His Trp Cys Lys Tyr Arg His Val Cys Thr His Asp Pro Lys Thr Cys 
        675                 680                 685             


Ser Phe Gln Glu Gly Arg Val Lys Leu Pro Glu Asp Cys Pro Gln Leu 
    690                 695                 700                 


Leu Arg Val Asp Lys Ile Leu Val Pro Val Glu Val Ile Lys Pro Ile 
705                 710                 715                 720 


Thr Leu Lys Ala Lys Asn Leu Pro Gln Pro Gln Ser Gly Gln Arg Gly 
                725                 730                 735     


Tyr Glu Cys Ile Leu Asn Ile Gln Gly Ser Glu Gln Arg Val Pro Ala 
            740                 745                 750         


Leu Arg Phe Asn Ser Ser Ser Val Gln Cys Gln Asn Thr Ser Tyr Ser 
        755                 760                 765             


Tyr Glu Gly Met Glu Ile Asn Asn Leu Pro Val Glu Leu Thr Val Val 
    770                 775                 780                 


Trp Asn Gly His Phe Asn Ile Asp Asn Pro Ala Gln Asn Lys Val His 
785                 790                 795                 800 


Leu Tyr Lys Cys Gly Ala Met Arg Glu Ser Cys Gly Leu Cys Leu Lys 
                805                 810                 815     


Ala Asp Pro Asp Phe Ala Cys Gly Trp Cys Gln Gly Pro Gly Gln Cys 
            820                 825                 830         


Thr Leu Arg Gln His Cys Pro Ala Gln Glu Ser Gln Trp Leu Glu Leu 
        835                 840                 845             


Ser Gly Ala Lys Ser Lys Cys Thr Asn Pro Arg Ile Thr Glu Ile Ile 
    850                 855                 860                 


Pro Val Thr Gly Pro Arg Glu Gly Gly Thr Lys Val Thr Ile Arg Gly 
865                 870                 875                 880 


Glu Asn Leu Gly Leu Glu Phe Arg Asp Ile Ala Ser His Val Lys Val 
                885                 890                 895     


Ala Gly Val Glu Cys Ser Pro Leu Val Asp Gly Tyr Ile Pro Ala Glu 
            900                 905                 910         


Gln Ile Val Cys Glu Met Gly Glu Ala Lys Pro Ser Gln His Ala Gly 
        915                 920                 925             


Phe Val Glu Ile Cys Val Ala Val Cys Arg Pro Glu Phe Met Ala Arg 
    930                 935                 940                 


Ser Ser Gln Leu Tyr Tyr Phe Met Thr Leu Thr Leu Ser Asp Leu Lys 
945                 950                 955                 960 


Pro Ser Arg Gly Pro Met Ser Gly Gly Thr Gln Val Thr Ile Thr Gly 
                965                 970                 975     


Thr Asn Leu Asn Ala Gly Ser Asn Val Val Val Met Phe Gly Lys Gln 
            980                 985                 990         


Pro Cys Leu Phe His Arg Arg Ser  Pro Ser Tyr Ile Val  Cys Asn Thr 
        995                 1000                 1005             


Thr Ser  Ser Asp Glu Val Leu  Glu Met Lys Val Ser  Val Gln Val 
    1010                 1015                 1020             


Asp Arg  Ala Lys Ile His Gln  Asp Leu Val Phe Gln  Tyr Val Glu 
    1025                 1030                 1035             


Asp Pro  Thr Ile Val Arg Ile  Glu Pro Glu Trp Ser  Ile Val Ser 
    1040                 1045                 1050             


Gly Asn  Thr Pro Ile Ala Val  Trp Gly Thr His Leu  Asp Leu Ile 
    1055                 1060                 1065             


Gln Asn  Pro Gln Ile Arg Ala  Lys His Gly Gly Lys  Glu His Ile 
    1070                 1075                 1080             


Asn Ile  Cys Glu Val Leu Asn  Ala Thr Glu Met Thr  Cys Gln Ala 
    1085                 1090                 1095             


Pro Ala  Leu Ala Leu Gly Pro  Asp His Gln Ser Asp  Leu Thr Glu 
    1100                 1105                 1110             


Arg Pro  Glu Glu Phe Gly Phe  Ile Leu Asp Asn Val  Gln Ser Leu 
    1115                 1120                 1125             


Leu Ile  Leu Asn Lys Thr Asn  Phe Thr Tyr Tyr Pro  Asn Pro Val 
    1130                 1135                 1140             


Phe Glu  Ala Phe Gly Pro Ser  Gly Ile Leu Glu Leu  Lys Pro Gly 
    1145                 1150                 1155             


Thr Pro  Ile Ile Leu Lys Gly  Lys Asn Leu Ile Pro  Pro Val Ala 
    1160                 1165                 1170             


Gly Gly  Asn Val Lys Leu Asn  Tyr Thr Val Leu Val  Gly Glu Lys 
    1175                 1180                 1185             


Pro Cys  Thr Val Thr Val Ser  Asp Val Gln Leu Leu  Cys Glu Ser 
    1190                 1195                 1200             


Pro Asn  Leu Ile Gly Arg His  Lys Val Met Ala Arg  Val Gly Gly 
    1205                 1210                 1215             


Met Glu  Tyr Ser Pro Gly Met  Val Tyr Ile Ala Pro  Asp Ser Pro 
    1220                 1225                 1230             


Leu Ser  Leu Pro Ala Ile Val  Ser Ile Ala Val Ala  Gly Gly Leu 
    1235                 1240                 1245             


Leu Ile  Ile Phe Ile Val Ala  Val Leu Ile Ala Tyr  Lys Arg Lys 
    1250                 1255                 1260             


Ser Arg  Glu Ser Asp Leu Thr  Leu Lys Arg Leu Gln  Met Gln Met 
    1265                 1270                 1275             


Asp Asn  Leu Glu Ser Arg Val  Ala Leu Glu Cys Lys  Glu Ala Phe 
    1280                 1285                 1290             


Ala Glu  Leu Gln Thr Asp Ile  His Glu Leu Thr Ser  Asp Leu Asp 
    1295                 1300                 1305             


Gly Ala  Gly Ile Pro Phe Leu  Asp Tyr Arg Thr Tyr  Thr Met Arg 
    1310                 1315                 1320             


Val Leu  Phe Pro Gly Ile Glu  Asp His Pro Val Leu  Arg Asp Leu 
    1325                 1330                 1335             


Glu Val  Pro Gly Tyr Arg Gln  Glu Arg Val Glu Lys  Gly Leu Lys 
    1340                 1345                 1350             


Leu Phe  Ala Gln Leu Ile Asn  Asn Lys Val Phe Leu  Leu Ser Phe 
    1355                 1360                 1365             


Ile Arg  Thr Leu Glu Ser Gln  Arg Ser Phe Ser Met  Arg Asp Arg 
    1370                 1375                 1380             


Gly Asn  Val Ala Ser Leu Ile  Met Thr Val Leu Gln  Ser Lys Leu 
    1385                 1390                 1395             


Glu Tyr  Ala Thr Asp Val Leu  Lys Gln Leu Leu Ala  Asp Leu Ile 
    1400                 1405                 1410             


Asp Lys  Asn Leu Glu Ser Lys  Asn His Pro Lys Leu  Leu Leu Arg 
    1415                 1420                 1425             


Arg Thr  Glu Ser Val Ala Glu  Lys Met Leu Thr Asn  Trp Phe Thr 
    1430                 1435                 1440             


Phe Leu  Leu Tyr Lys Phe Leu  Lys Glu Cys Ala Gly  Glu Pro Leu 
    1445                 1450                 1455             


Phe Ser  Leu Phe Cys Ala Ile  Lys Gln Gln Met Glu  Lys Gly Pro 
    1460                 1465                 1470             


Ile Asp  Ala Ile Thr Gly Glu  Ala Arg Tyr Ser Leu  Ser Glu Asp 
    1475                 1480                 1485             


Lys Leu  Ile Arg Gln Gln Ile  Asp Tyr Lys Thr Leu  Val Leu Ser 
    1490                 1495                 1500             


Cys Val  Ser Pro Asp Asn Ala  Asn Ser Pro Glu Val  Pro Val Lys 
    1505                 1510                 1515             


Ile Leu  Asn Cys Asp Thr Ile  Thr Gln Val Lys Glu  Lys Ile Leu 
    1520                 1525                 1530             


Asp Ala  Ile Phe Lys Asn Val  Pro Cys Ser His Arg  Pro Lys Ala 
    1535                 1540                 1545             


Ala Asp  Met Asp Leu Glu Trp  Arg Gln Gly Ser Gly  Ala Arg Met 
    1550                 1555                 1560             


Ile Leu  Gln Asp Glu Asp Ile  Thr Thr Lys Ile Glu  Asn Asp Trp 
    1565                 1570                 1575             


Lys Arg  Leu Asn Thr Leu Ala  His Tyr Gln Val Pro  Asp Gly Ser 
    1580                 1585                 1590             


Val Val  Ala Leu Val Ser Lys  Gln Val Thr Ala Tyr  Asn Ala Val 
    1595                 1600                 1605             


Asn Asn  Ser Thr Val Ser Arg  Thr Ser Ala Ser Lys  Tyr Glu Asn 
    1610                 1615                 1620             


Met Ile  Arg Tyr Thr Gly Ser  Pro Asp Ser Leu Arg  Ser Arg Thr 
    1625                 1630                 1635             


Pro Met  Ile Thr Pro Asp Leu  Glu Ser Gly Val Lys  Met Trp His 
    1640                 1645                 1650             


Leu Val  Lys Asn His Glu His  Gly Asp Gln Lys Glu  Gly Asp Arg 
    1655                 1660                 1665             


Gly Ser  Lys Met Val Ser Glu  Ile Tyr Leu Thr Arg  Leu Leu Ala 
    1670                 1675                 1680             


Thr Lys  Gly Thr Leu Gln Lys  Phe Val Asp Asp Leu  Phe Glu Thr 
    1685                 1690                 1695             


Ile Phe  Ser Thr Ala His Arg  Gly Ser Ala Leu Pro  Leu Ala Ile 
    1700                 1705                 1710             


Lys Tyr  Met Phe Asp Phe Leu  Asp Glu Gln Ala Asp  Lys His Gly 
    1715                 1720                 1725             


Ile His  Asp Pro His Val Arg  His Thr Trp Lys Ser  Asn Cys Leu 
    1730                 1735                 1740             


Pro Leu  Arg Phe Trp Val Asn  Met Ile Lys Asn Pro  Gln Phe Val 
    1745                 1750                 1755             


Phe Asp  Ile His Lys Asn Ser  Ile Thr Asp Ala Cys  Leu Ser Val 
    1760                 1765                 1770             


Val Ala  Gln Thr Phe Met Asp  Ser Cys Ser Thr Ser  Glu His Arg 
    1775                 1780                 1785             


Leu Gly  Lys Asp Ser Pro Ser  Asn Lys Leu Leu Tyr  Ala Lys Asp 
    1790                 1795                 1800             


Ile Pro  Ser Tyr Lys Asn Trp  Val Glu Arg Tyr Tyr  Ser Asp Ile 
    1805                 1810                 1815             


Gly Lys  Met Pro Ala Ile Ser  Asp Gln Asp Met Asn  Ala Tyr Leu 
    1820                 1825                 1830             


Ala Glu  Gln Ser Arg Met His  Met Asn Glu Phe Asn  Thr Met Ser 
    1835                 1840                 1845             


Ala Leu  Ser Glu Ile Phe Ser  Tyr Val Gly Lys Tyr  Ser Glu Glu 
    1850                 1855                 1860             


Ile Leu  Gly Pro Leu Asp His  Asp Asp Gln Cys Gly  Lys Gln Lys 
    1865                 1870                 1875             


Leu Ala  Tyr Lys Leu Glu Gln  Val Ile Thr Leu Met  Ser Leu Asp 
    1880                 1885                 1890             


Ser 
    


<210>  3
<211>  849
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcttccc tggggcagat cctcttctgg agcataatta gcatcatcat tattctggct       60

ggagcaattg cactcatcat tggctttggt atttcaggga gacactccat cacagtcact      120

actgtcgcct cagctgggaa cattggggag gatggaatcc tgagctgcac ttttgaacct      180

gacatcaaac tttctgatat cgtgatacaa tggctgaagg aaggtgtttt aggcttggtc      240

catgagttca aagaaggcaa agatgagctg tcggagcagg atgaaatgtt cagaggccgg      300

acagcagtgt ttgctgatca agtgatagtt ggcaatgcct ctttgcggct gaaaaacgtg      360

caactcacag atgctggcac ctacaaatgt tatatcatca cttctaaagg caaggggaat      420

gctaaccttg agtataaaac tggagccttc agcatgccgg aagtgaatgt ggactataat      480

gccagctcag agaccttgcg gtgtgaggct ccccgatggt tcccccagcc cacagtggtc      540

tgggcatccc aagttgacca gggagccaac ttctcggaag tctccaatac cagctttgag      600

ctgaactctg agaatgtgac catgaaggtt gtgtctgtgc tctacaatgt tacgatcaac      660

aacacatact cctgtatgat tgaaaatgac attgccaaag caacagggga tatcaaagtg      720

acagaatcgg agatcaaaag gcggagtcac ctacagctgc taaactcaaa ggcttctctg      780

tgtgtctctt ctttctttgc catcagctgg gcacttctgc ctctcagccc ttacctgatg      840

ctaaaataa                                                              849


<210>  4
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  5
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala 
225                 230                 235                 240 


Ile Ser Trp Ala Leu Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
                245                 250                 255 


<210>  6
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  7
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala 
225                 230                 235                 240 


Ile Ser Trp Ala Leu Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
                245                 250                 255 


<210>  8
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide - IgV domain

<400>  8

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn 
    


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - IgV domain

<400>  9

His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly Glu 
1               5                   10                  15      


Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp 
            20                  25                  30          


Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His Glu 
        35                  40                  45              


Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe Arg 
    50                  55                  60                  


Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser 
65                  70                  75                  80  


Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys 
                85                  90                  95      


Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys 
            100                 105                 110         


<210>  10
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide: IgV domain

<400>  10

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn 
    


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - IgV domain

<400>  11

His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly Glu 
1               5                   10                  15      


Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp 
            20                  25                  30          


Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His Glu 
        35                  40                  45              


Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe Arg 
    50                  55                  60                  


Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser 
65                  70                  75                  80  


Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys 
                85                  90                  95      


Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys 
            100                 105                 110         


<210>  12
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - IgC domain

<400>  12

Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg 
1               5                   10                  15      


Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly 
            20                  25                  30          


Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu 
        35                  40                  45              


Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn 
    50                  55                  60                  


Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly 
65                  70                  75                  80  


Asp Ile Lys Val Thr 
                85  


<210>  13
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - IgC domain

<400>  13

Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
1               5                   10                  15      


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
            20                  25                  30          


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
        35                  40                  45              


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
    50                  55                  60                  


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
65                  70                  75                  80  


Lys Ala Thr Gly Asp Ile Lys Val Thr 
                85                  


<210>  14
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - IgC domain

<400>  14

Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr 
1               5                   10                  15      


Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp 
            20                  25                  30          


Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr 
        35                  40                  45              


Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val 
    50                  55                  60                  


Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn 
65                  70                  75                  80  


Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile 
                85                  90                  95      


Lys Arg Arg Ser 
            100 


<210>  15
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - IgC domain

<400>  15

Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala 
1               5                   10                  15      


Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp 
            20                  25                  30          


Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn 
        35                  40                  45              


Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr 
    50                  55                  60                  


Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala 
65                  70                  75                  80  


Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser 
                85                  90                  95  


<210>  16
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - IgC domain

<400>  16

Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe 
1               5                   10                  15      


Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn 
            20                  25                  30          


Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val 
        35                  40                  45              


Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr 
    50                  55                  60                  


Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile 
65                  70                  75                  80  


Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser 
                85                  90      


<210>  17
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - extracellular domain

<400>  17

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser 
    210                 215                 220         


<210>  18
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - extracellular domain

<400>  18

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser 
    210                 215                 220         


<210>  19
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - IgC domain

<400>  19

Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu 
1               5                   10                  15      


Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val 
            20                  25                  30          


Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu 
        35                  40                  45              


Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val 
    50                  55                  60                  


Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys 
65                  70                  75                  80  


Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Gln Gln Ser 
                85                  90                  95      


His Leu Gln Leu Leu Asn Ser Lys Ala Ser 
            100                 105     


<210>  20
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  20

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu 
            20                  25                  30          


Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala 
        35                  40                  45              


Ser Gln Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser 
    50                  55                  60                  


Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu 
65                  70                  75                  80  


Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp 
                85                  90                  95      


Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys 
            100                 105                 110         


Gln Gln Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Glu Pro Lys 
        115                 120                 125             


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly 
        355     


<210>  21
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  21

Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu 
1               5                   10                  15      


Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val 
            20                  25                  30          


Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu 
        35                  40                  45              


Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val 
    50                  55                  60                  


Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys 
65                  70                  75                  80  


Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Gln Gln Ser 
                85                  90                  95      


His Leu Gln Leu Leu Asn Ser Lys Ala Ser Glu Pro Lys Ser Ser Asp 
            100                 105                 110         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        115                 120                 125             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    130                 135                 140                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
145                 150                 155                 160 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                165                 170                 175     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            180                 185                 190         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        195                 200                 205             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    210                 215                 220                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
225                 230                 235                 240 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                245                 250                 255     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            260                 265                 270         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        275                 280                 285             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    290                 295                 300                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
305                 310                 315                 320 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                325                 330                 335     


Gly 
    


<210>  22
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  22

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  23
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  23

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  24
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  24

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  25
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  25

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  26
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  26

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr 
            20                  25                  30          


Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr 
        35                  40                  45              


Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys 
    50                  55                  60                  


Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu 
65                  70                  75                  80  


Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala 
                85                  90                  95      


Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln 
            100                 105                 110         


Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly 
        115                 120                 125             


Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Glu Pro Lys Ser 
    130                 135                 140                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly 
    370     


<210>  27
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  27

Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser 
1               5                   10                  15      


Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro 
            20                  25                  30          


Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val 
        35                  40                  45              


Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu 
    50                  55                  60                  


Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val 
65                  70                  75                  80  


Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp 
                85                  90                  95      


Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn 
            100                 105                 110         


Ala Asn Leu Glu Tyr Lys Thr Gly Ala Glu Pro Lys Ser Ser Asp Lys 
        115                 120                 125             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


<210>  28
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  28

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr 
            20                  25                  30          


Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr 
        35                  40                  45              


Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys 
    50                  55                  60                  


Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu 
65                  70                  75                  80  


Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala 
                85                  90                  95      


Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln 
            100                 105                 110         


Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly 
        115                 120                 125             


Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro 
    130                 135                 140                 


Glu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375     


<210>  29
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  29

Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser 
1               5                   10                  15      


Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro 
            20                  25                  30          


Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val 
        35                  40                  45              


Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu 
    50                  55                  60                  


Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val 
65                  70                  75                  80  


Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp 
                85                  90                  95      


Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn 
            100                 105                 110         


Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Glu Pro 
        115                 120                 125             


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            260                 265                 270         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         


Ser Leu Ser Pro Gly 
        355         


<210>  30
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  30

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr 
            20                  25                  30          


Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr 
        35                  40                  45              


Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys 
    50                  55                  60                  


Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu 
65                  70                  75                  80  


Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala 
                85                  90                  95      


Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln 
            100                 105                 110         


Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly 
        115                 120                 125             


Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro 
    130                 135                 140                 


Glu Val Asn Val Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
145                 150                 155                 160 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                165                 170                 175     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            180                 185                 190         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        195                 200                 205             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    210                 215                 220                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
225                 230                 235                 240 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                245                 250                 255     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            260                 265                 270         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380 


<210>  31
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  31

Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser 
1               5                   10                  15      


Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro 
            20                  25                  30          


Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val 
        35                  40                  45              


Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu 
    50                  55                  60                  


Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val 
65                  70                  75                  80  


Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp 
                85                  90                  95      


Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn 
            100                 105                 110         


Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn 
        115                 120                 125             


Val Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    130                 135                 140                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            180                 185                 190         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        195                 200                 205             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
225                 230                 235                 240 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                245                 250                 255     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            260                 265                 270         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        275                 280                 285             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    290                 295                 300                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
305                 310                 315                 320 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                325                 330                 335     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360     


<210>  32
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  32

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr 
            20                  25                  30          


Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr 
        35                  40                  45              


Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys 
    50                  55                  60                  


Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu 
65                  70                  75                  80  


Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala 
                85                  90                  95      


Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln 
            100                 105                 110         


Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly 
        115                 120                 125             


Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro 
    130                 135                 140                 


Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu 
145                 150                 155                 160 


Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val 
                165                 170                 175     


Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu 
            180                 185                 190         


Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val 
        195                 200                 205             


Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys 
    210                 215                 220                 


Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser 
225                 230                 235                 240 


His Leu Gln Leu Leu Asn Ser Lys Ala Ser Glu Ser Lys Tyr Gly Pro 
                245                 250                 255     


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
    290                 295                 300                 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475             


<210>  33
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  33

Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser 
1               5                   10                  15      


Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro 
            20                  25                  30          


Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val 
        35                  40                  45              


Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu 
    50                  55                  60                  


Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val 
65                  70                  75                  80  


Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp 
                85                  90                  95      


Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn 
            100                 105                 110         


Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn 
        115                 120                 125             


Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg 
    130                 135                 140                 


Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly 
145                 150                 155                 160 


Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu 
                165                 170                 175     


Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn 
            180                 185                 190         


Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly 
        195                 200                 205             


Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln 
    210                 215                 220                 


Leu Leu Asn Ser Lys Ala Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 


<210>  34
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polpypeptide - fusion protein

<400>  34

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr 
            20                  25                  30          


Thr Phe Thr Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Asp Leu Ser Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Ser Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Ile Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg 
225                 230                 235                 240 


Ser Gln Leu Gln Leu Leu Asn Ser Gly Glu Pro Arg Gly Pro Thr Ile 
                245                 250                 255     


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
        275                 280                 285             


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
    290                 295                 300                 


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
305                 310                 315                 320 


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
                325                 330                 335     


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
            340                 345                 350         


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
    370                 375                 380                 


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
385                 390                 395                 400 


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
                405                 410                 415     


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
        435                 440                 445             


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
    450                 455                 460                 


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  35
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  35

Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser 
    50                  55                  60                  


Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Ser Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
225                 230                 235                 240 


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
            260                 265                 270         


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
        275                 280                 285             


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
    290                 295                 300                 


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
305                 310                 315                 320 


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
                325                 330                 335     


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
            340                 345                 350         


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
        355                 360                 365             


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
    370                 375                 380                 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
385                 390                 395                 400 


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
            420                 425                 430         


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
        435                 440                 445             


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460             


<210>  36
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide - encodes a fusion protein

<400>  36
atggagtggt catgggtttt tctgttcttt cttagcgtga ctacaggcgt ccattcagga       60

ttcggcataa gcggcaagca cttcatcaca gttacaacgt ttacaagtgc ggggaacatt      120

ggggaagatg gaacattgtc atgtacattt gagccagata tcaaactcaa tggaatagta      180

attcagtggc ttaaggaggg catcaagggc ctggtccacg aatttaagga ggggaaagac      240

gatctgtctc agcagcacga gatgttcagg ggcagaaccg ccgtcttcgc agaccaggtt      300

gtggtaggca acgccagttt gcggctgaaa aacgtgcagc tgactgacgc cggcacctac      360

acatgctata tccggtcctc taagggcaag gggaacgcta atctcgagta caaaacaggc      420

gccttttcta tgccagagat caacgtggac tataacgcaa gctctgaaag tctgagatgc      480

gaggcgccaa ggtggttccc tcagcccacc gtcgcgtggg cttcccaggt ggatcaaggc      540

gccaactttt ctgaggtttc taacaccagc ttcgaactga acagcgaaaa tgtgacaatg      600

aaggtagtca gcgttctgta taacgtgacc atcaacaata cttactcctg tatgatagaa      660

aatgatatag ccaaggctac aggagatatt aaagtgacgg attcagaagt gaaaaggagg      720

agtcaactgc aactcttgaa tagcggcgag ccaagaggtc ctacgatcaa gccctgcccg      780

ccttgtaaat gcccagctcc aaatttgctg ggtggaccgt cagtctttat cttcccgcca      840

aagataaagg acgtcttgat gattagtctg agccccatcg tgacatgcgt tgtggtggat      900

gtttcagagg atgaccccga cgtgcaaatc agttggttcg ttaacaacgt ggaggtgcat      960

accgctcaaa cccagaccca cagagaggat tataacagca ccctgcgggt agtgtccgcc     1020

ctgccgatcc agcatcagga ttggatgagc gggaaagagt tcaagtgtaa ggtaaacaac     1080

aaagatctgc cagcgccgat tgaacgaacc attagcaagc cgaaagggag cgtgcgcgca     1140

cctcaggttt acgtccttcc tccaccagaa gaggagatga cgaaaaagca ggtgaccctg     1200

acatgcatgg taactgactt tatgccagaa gatatttacg tggaatggac taataacgga     1260

aagacagagc tcaattacaa gaacactgag cctgttctgg attctgatgg cagctacttt     1320

atgtactcca aattgagggt cgagaagaag aattgggtcg agagaaacag ttatagttgc     1380

tcagtggtgc atgagggcct ccataatcat cacaccacaa agtccttcag ccgaacgccc     1440

gggaaatga                                                             1449


<210>  37
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr His Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Arg Ser Thr Pro Gly Tyr 
                805                 810                 815     


Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly Asn 
            820                 825                 830         


Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser 
        835                 840                 845             


Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr Cys 
    850                 855                 860                 


Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu Glu 
865                 870                 875                 880 


Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp Lys 
                885                 890                 895     


Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
            900                 905     


<210>  38
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Arg Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Val Asp Ile 
                805                 810                 815     


Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu 
            820                 825                 830         


Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly 
        835                 840                 845             


Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro 
    850                 855                 860                 


Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly 
865                 870                 875                 880 


Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly 
                885                 890                 895     


Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu 
            900                 905                 910         


Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn His Gln Lys Cys Cys 
        915                 920                 925             


Ser Glu Ala 
    930     


<210>  39
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Gly Thr Leu Leu Pro Gly Thr 
                805                 810                 815     


Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro Ile Pro Ala Tyr Trp 
            820                 825                 830         


Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu Val Leu Val Ser Val 
        835                 840                 845             


Ala Leu Ala Leu Val Leu His Tyr His Arg Phe Arg Tyr Ala Ala Lys 
    850                 855                 860                 


Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser His Tyr Thr Asn Gly 
865                 870                 875                 880 


Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile Lys Leu Glu Gln Asp 
                885                 890                 895     


Arg Gly Ser His Cys 
            900     


<210>  40
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Pro Arg Ala Pro His Phe Met Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Pro His Thr Gln Ala Ala Phe Pro Gln Asp Pro Leu Pro 
            20                  25                  30          


Leu Leu Ile Ser Asp Leu Gln Gly Thr Ser Pro Leu Ser Trp Phe Arg 
        35                  40                  45              


Gly Leu Glu Asp Asp Ala Val Ala Ala Glu Leu Gly Leu Asp Phe Gln 
    50                  55                  60                  


Arg Phe Leu Thr Leu Asn Arg Thr Leu Leu Val Ala Ala Arg Asp His 
65                  70                  75                  80  


Val Phe Ser Phe Asp Leu Gln Ala Glu Glu Glu Gly Glu Gly Leu Val 
                85                  90                  95      


Pro Asn Lys Tyr Leu Thr Trp Arg Ser Gln Asp Val Glu Asn Cys Ala 
            100                 105                 110         


Val Arg Gly Lys Leu Thr Asp Glu Cys Tyr Asn Tyr Ile Arg Val Leu 
        115                 120                 125             


Val Pro Trp Asp Ser Gln Thr Leu Leu Ala Cys Gly Thr Asn Ser Phe 
    130                 135                 140                 


Ser Pro Val Cys Arg Ser Tyr Gly Ile Thr Ser Leu Gln Gln Glu Gly 
145                 150                 155                 160 


Glu Glu Leu Ser Gly Gln Ala Arg Cys Pro Phe Asp Ala Thr Gln Ser 
                165                 170                 175     


Asn Val Ala Ile Phe Ala Glu Gly Ser Leu Tyr Ser Ala Thr Ala Ala 
            180                 185                 190         


Asp Phe Gln Ala Ser Asp Ala Val Val Tyr Arg Ser Leu Gly Pro Gln 
        195                 200                 205             


Pro Pro Leu Arg Ser Ala Lys Tyr Asp Ser Lys Trp Leu Arg Glu Pro 
    210                 215                 220                 


His Phe Val Gln Ala Leu Glu His Gly Asp His Val Tyr Phe Phe Phe 
225                 230                 235                 240 


Arg Glu Val Ser Val Glu Asp Ala Arg Leu Gly Arg Val Gln Phe Ser 
                245                 250                 255     


Arg Val Ala Arg Val Cys Lys Arg Asp Met Gly Gly Ser Pro Arg Ala 
            260                 265                 270         


Leu Asp Arg His Trp Thr Ser Phe Leu Lys Leu Arg Leu Asn Cys Ser 
        275                 280                 285             


Val Pro Gly Asp Ser Thr Phe Tyr Phe Asp Val Leu Gln Ala Leu Thr 
    290                 295                 300                 


Gly Pro Val Asn Leu His Gly Arg Ser Ala Leu Phe Gly Val Phe Thr 
305                 310                 315                 320 


Thr Gln Thr Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Tyr Leu 
                325                 330                 335     


Asp Glu Ile Glu Arg Gly Phe Glu Gly Lys Phe Lys Glu Gln Arg Ser 
            340                 345                 350         


Leu Asp Gly Ala Trp Thr Pro Val Ser Glu Asp Arg Val Pro Ser Pro 
        355                 360                 365             


Arg Pro Gly Ser Cys Ala Gly Val Gly Gly Ala Ala Leu Phe Ser Ser 
    370                 375                 380                 


Ser Arg Asp Leu Pro Asp Asp Val Leu Thr Phe Ile Lys Ala His Pro 
385                 390                 395                 400 


Leu Leu Asp Pro Ala Val Pro Pro Val Thr His Gln Pro Leu Leu Thr 
                405                 410                 415     


Leu Thr Ser Arg Ala Leu Leu Thr Gln Val Ala Val Asp Gly Met Ala 
            420                 425                 430         


Gly Pro His Ser Asn Ile Thr Val Met Phe Leu Gly Ser Asn Asp Gly 
        435                 440                 445             


Thr Val Leu Lys Val Leu Thr Pro Gly Gly Arg Ser Gly Gly Pro Glu 
    450                 455                 460                 


Pro Ile Leu Leu Glu Glu Ile Asp Ala Tyr Ser Pro Ala Arg Cys Ser 
465                 470                 475                 480 


Gly Lys Arg Thr Ala Gln Thr Ala Arg Arg Ile Ile Gly Leu Glu Leu 
                485                 490                 495     


Asp Thr Glu Gly His Arg Leu Phe Val Ala Phe Ser Gly Cys Ile Val 
            500                 505                 510         


Tyr Leu Pro Leu Ser Arg Cys Ala Arg His Gly Ala Cys Gln Arg Ser 
        515                 520                 525             


Cys Leu Ala Ser Gln Asp Pro Tyr Cys Gly Trp His Ser Ser Arg Gly 
    530                 535                 540                 


Cys Val Asp Ile Arg Gly Ser Gly Gly Thr Asp Val Asp Gln Ala Gly 
545                 550                 555                 560 


Asn Gln Glu Ser Met Glu His Gly Asp Cys Gln Asp Gly Ala Thr Gly 
                565                 570                 575     


Ser Gln Ser Gly Pro Gly Asp Ser Ala Tyr Gly Val Arg Arg Asp Leu 
            580                 585                 590         


Pro Pro Ala Ser Ala Ser Arg Ser Val Pro Ile Pro Leu Leu Leu Ala 
        595                 600                 605             


Ser Val Ala Ala Ala Phe Ala Leu Gly Ala Ser Val Ser Gly Leu Leu 
    610                 615                 620                 


Val Ser Cys Ala Cys Arg Arg Ala His Arg Arg Arg Gly Lys Asp Ile 
625                 630                 635                 640 


Glu Thr Pro Gly Leu Pro Arg Pro Leu Ser Leu Arg Ser Leu Ala Arg 
                645                 650                 655     


Leu His Gly Gly Gly Pro Glu Pro Pro Pro Pro Ser Lys Asp Gly Asp 
            660                 665                 670         


Ala Val Gln Thr Pro Gln Leu Tyr Thr Thr Phe Leu Pro Pro Pro Glu 
        675                 680                 685             


Gly Val Pro Pro Pro Glu Leu Ala Cys Leu Pro Thr Pro Glu Ser Thr 
    690                 695                 700                 


Pro Glu Leu Pro Val Lys His Leu Arg Ala Ala Gly Asp Pro Trp Glu 
705                 710                 715                 720 


Trp Asn Gln Asn Arg Asn Asn Ala Lys Glu Gly Pro Gly Arg Ser Arg 
                725                 730                 735     


Gly Gly His Ala Ala Gly Gly Pro Ala Pro Arg Val Leu Val Arg Pro 
            740                 745                 750         


Pro Pro Pro Gly Cys Pro Gly Gln Ala Val Glu Val Thr Thr Leu Glu 
        755                 760                 765             


Glu Leu Leu Arg Tyr Leu His Gly Pro Gln Pro Pro Arg Lys Gly Ala 
    770                 775                 780                 


Glu Pro Pro Ala Pro Leu Thr Ser Arg Ala Leu Pro Pro Glu Pro Ala 
785                 790                 795                 800 


Pro Ala Leu Leu Gly Gly Pro Ser Pro Arg Pro His Glu Cys Ala Ser 
                805                 810                 815     


Pro Leu Arg Leu Asp Val Pro Pro Glu Gly Arg Cys Ala Ser Ala Pro 
            820                 825                 830         


Ala Arg Pro Ala Leu Ser Ala Pro Ala Pro Arg Leu Gly Val Gly Gly 
        835                 840                 845             


Gly Arg Arg Leu Pro Phe Ser Gly His Arg Ala Pro Pro Ala Leu Leu 
    850                 855                 860                 


Thr Arg Val Pro Ser Gly Gly Pro Ser Arg Tyr Ser Gly Gly Pro Gly 
865                 870                 875                 880 


Lys His Leu Leu Tyr Leu Gly Arg Pro Glu Gly Tyr Arg Gly Arg Ala 
                885                 890                 895     


Leu Lys Arg Val Asp Val Glu Lys Pro Gln Leu Ser Leu Lys Pro Pro 
            900                 905                 910         


Leu Val Gly Pro Ser Ser Arg Gln Ala Val Pro Asn Gly Gly Arg Phe 
        915                 920                 925             


Asn Phe 
    930 


<210>  41
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Pro Arg Ala Pro His Phe Met Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Pro His Thr Gln Ala Ala Phe Pro Gln Asp Pro Leu Pro 
            20                  25                  30          


Leu Leu Ile Ser Asp Leu Gln Gly Thr Ser Pro Leu Ser Trp Phe Arg 
        35                  40                  45              


Gly Leu Glu Asp Asp Ala Val Ala Ala Glu Leu Gly Leu Asp Phe Gln 
    50                  55                  60                  


Arg Phe Leu Thr Leu Asn Arg Thr Leu Leu Val Ala Ala Arg Asp His 
65                  70                  75                  80  


Val Phe Ser Phe Asp Leu Gln Ala Glu Glu Glu Gly Glu Gly Leu Val 
                85                  90                  95      


Pro Asn Lys Tyr Leu Thr Trp Arg Ser Gln Asp Val Glu Asn Cys Ala 
            100                 105                 110         


Val Arg Gly Lys Leu Thr Asp Glu Cys Tyr Asn Tyr Ile Arg Val Leu 
        115                 120                 125             


Val Pro Trp Asp Ser Gln Thr Leu Leu Ala Cys Gly Thr Asn Ser Phe 
    130                 135                 140                 


Ser Pro Val Cys Arg Ser Tyr Gly Ile Thr Ser Leu Gln Gln Glu Gly 
145                 150                 155                 160 


Glu Glu Leu Ser Gly Gln Ala Arg Cys Pro Phe Asp Ala Thr Gln Ser 
                165                 170                 175     


Asn Val Ala Ile Phe Ala Glu Gly Ser Leu Tyr Ser Ala Thr Ala Ala 
            180                 185                 190         


Asp Phe Gln Ala Ser Asp Ala Val Val Tyr Arg Ser Leu Gly Pro Gln 
        195                 200                 205             


Pro Pro Leu Arg Ser Ala Lys Tyr Asp Ser Lys Trp Leu Arg Glu Pro 
    210                 215                 220                 


His Phe Val Gln Ala Leu Glu His Gly Asp His Val Tyr Phe Phe Phe 
225                 230                 235                 240 


Arg Glu Val Ser Val Glu Asp Ala Arg Leu Gly Arg Val Gln Phe Ser 
                245                 250                 255     


Arg Val Ala Arg Val Cys Lys Arg Asp Met Gly Gly Ser Pro Arg Ala 
            260                 265                 270         


Leu Asp Arg His Trp Thr Ser Phe Leu Lys Leu Arg Leu Asn Cys Ser 
        275                 280                 285             


Val Pro Gly Asp Ser Thr Phe Tyr Phe Asp Val Leu Gln Ala Leu Thr 
    290                 295                 300                 


Gly Pro Val Asn Leu His Gly Arg Ser Ala Leu Phe Gly Val Phe Thr 
305                 310                 315                 320 


Thr Gln Thr Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Phe Tyr Leu 
                325                 330                 335     


Asp Glu Ile Glu Arg Gly Phe Glu Gly Lys Phe Lys Glu Gln Arg Ser 
            340                 345                 350         


Leu Asp Gly Ala Trp Thr Pro Val Ser Glu Asp Arg Val Pro Ser Pro 
        355                 360                 365             


Arg Pro Gly Ser Cys Pro Ala His Ser Ser Pro Leu Gly Arg Ser Leu 
    370                 375                 380                 


Gln Val Leu Arg Gly Ser Arg Glu Ala Pro Pro Val Pro Gly Pro Ala 
385                 390                 395                 400 


Arg Gly Leu Pro Gly Pro Arg Pro Glu Lys Gly Gly Arg Arg Glu Ala 
                405                 410                 415     


Pro Val Val Pro Glu Ala Ser Pro Arg Arg Ala Leu Leu Pro Pro Gly 
            420                 425                 430         


Arg Pro Glu Arg Arg Pro Phe Gln Leu Leu Lys Gly Ala Val His Gly 
        435                 440                 445             


Leu Gln Arg Gly Glu Arg Pro Ser Pro Leu Gly His Glu Leu Asp Ala 
    450                 455                 460                 


Leu Gln Asp Val Ser Pro Pro Pro Arg Pro Ala Pro Pro Ala Phe Pro 
465                 470                 475                 480 


Thr Arg Arg Val Ser Arg Gly Pro Phe Ser Pro Arg Val Tyr Leu Leu 
                485                 490                 495     


Thr Val Phe Pro Pro Val Leu Asp Arg Arg Val Gly Gly Glu Lys Pro 
            500                 505                 510         


Val Ser Ser Val Ser Gln His Phe Arg Gly Ser Trp Arg Thr Pro Thr 
        515                 520                 525             


Pro Arg Ser Leu Pro Ala Lys Leu Pro 
    530                 535         


<210>  42
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Pro Arg Ala Pro His Phe Met Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Pro His Thr Gln Ala Ala Phe Pro Gln Asp Pro Leu Pro 
            20                  25                  30          


Leu Leu Ile Ser Asp Leu Gln Gly Thr Ser Pro Leu Ser Trp Phe Arg 
        35                  40                  45              


Gly Leu Glu Asp Asp Ala Val Ala Ala Glu Leu Gly Leu Asp Phe Gln 
    50                  55                  60                  


Arg Phe Leu Thr Leu Asn Arg Thr Leu Leu Val Ala Ala Arg Asp His 
65                  70                  75                  80  


Val Phe Ser Phe Asp Leu Gln Ala Glu Glu Glu Gly Glu Gly Leu Val 
                85                  90                  95      


Pro Asn Lys Tyr Leu Thr Trp Arg Ser Gln Asp Val Glu Asn Cys Ala 
            100                 105                 110         


Val Arg Gly Lys Leu Thr Asp Glu Cys Tyr Asn Tyr Ile Arg Val Leu 
        115                 120                 125             


Val Pro Trp Asp Ser Gln Thr Leu Leu Ala Cys Gly Thr Asn Ser Phe 
    130                 135                 140                 


Ser Pro Val Cys Arg Ser Tyr Gly Ile Thr Ser Leu Gln Gln Glu Gly 
145                 150                 155                 160 


Glu Glu Leu Ser Gly Gln Ala Arg Cys Pro Phe Asp Ala Thr Gln Ser 
                165                 170                 175     


Asn Val Ala Ile Phe Ala Glu Gly Ser Leu Tyr Ser Ala Thr Ala Ala 
            180                 185                 190         


Asp Phe Gln Ala Ser Asp Ala Val Val Tyr Arg Ser Leu Gly Pro Gln 
        195                 200                 205             


Pro Pro Leu Arg Ser Ala Lys Tyr Asp Ser Lys Trp Leu Arg Glu Pro 
    210                 215                 220                 


His Phe Val Gln Ala Leu Glu His Gly Asp His Val Tyr Phe Phe Phe 
225                 230                 235                 240 


Arg Glu Val Ser Val Glu Asp Ala Arg Leu Gly Arg Val Gln Phe Ser 
                245                 250                 255     


Arg Val Ala Arg Val Cys Lys Arg Asp Met Gly Gly Ser Pro Arg Ala 
            260                 265                 270         


Leu Asp Arg His Trp Thr Ser Phe Leu Lys Leu Arg Leu Asn Cys Ser 
        275                 280                 285             


Val Pro Gly Asp Ser Thr Phe Tyr Phe Asp Val Leu Gln Ala Leu Thr 
    290                 295                 300                 


Gly Pro Val Asn Leu His Gly Arg Ser Ala Leu Phe Gly Val Phe Thr 
305                 310                 315                 320 


Thr Gln Thr Asn Ser Ile Pro Gly Ser Ala Val Cys Ala Ser Tyr Leu 
                325                 330                 335     


Asp Glu Ile Glu Arg Gly Phe Glu Gly Lys Phe Lys Glu Gln Arg Ser 
            340                 345                 350         


Leu Asp Gly Ala Trp Thr Pro Val Ser Glu Asp Arg Val Pro Ser Pro 
        355                 360                 365             


Arg Pro Gly Ser Cys Ala Gly Val Gly Gly Ala Ala Leu Phe Ser Ser 
    370                 375                 380                 


Ser Arg Asp Leu Pro Ser Ser Gly Pro Pro Pro Ala Arg Pro Ser Arg 
385                 390                 395                 400 


Thr Ala Ala Val Ser Thr Phe Lys Gly Ser Gly Pro Arg Pro Pro Ala 
                405                 410                 415     


Trp Gly Ala Pro Glu Ser Ser Arg Pro Arg Ala Gly Arg Ser Ser Gly 
            420                 425                 430         


Arg Phe Thr Ala Pro Ser Pro Arg Thr Ser Ser Leu Pro Asp Ser Gln 
        435                 440                 445             


Ser Leu Pro Arg Pro Leu Phe Ala Ser Gly Leu Phe Ile Asp Cys Leu 
    450                 455                 460                 


Ser Pro Cys Pro Arg Gln Lys Ser Gly Arg 
465                 470                 


<210>  43
<211>  771
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      


Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          


Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              


Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  


Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  


Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      


Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys 
            100                 105                 110         


Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             


Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 


Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 


His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     


Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         


Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             


His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 


Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 


Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     


Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         


Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 


Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 


Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     


Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         


Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             


Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 


Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 


Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met 
                405                 410                 415     


Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         


Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             


Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 


Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 


Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     


Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         


Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             


Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg 
    530                 535                 540                 


Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 


Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His Asp Asn His His 
                565                 570                 575     


Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser 
            580                 585                 590         


Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp 
        595                 600                 605             


Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp 
    610                 615                 620                 


Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln 
625                 630                 635                 640 


Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe 
                645                 650                 655     


Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His 
            660                 665                 670         


Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr 
        675                 680                 685             


Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg 
    690                 695                 700                 


Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu 
705                 710                 715                 720 


Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg 
                725                 730                 735     


Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu 
            740                 745                 750         


Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro 
        755                 760                 765             


Arg Ser Val 
    770     


<210>  44
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  44

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  45
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  45

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  46
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  46

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  47
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  47

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  48
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  48

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  49
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  49

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  50
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  50

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  51
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  51

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  52
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  52

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  53
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  53

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  54
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  54

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  55
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  55

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  56
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  56

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  57
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  57

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  58
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  58

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr 
            20                  25                  30          


Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr 
        35                  40                  45              


Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys 
    50                  55                  60                  


Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu 
65                  70                  75                  80  


Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala 
                85                  90                  95      


Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln 
            100                 105                 110         


Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly 
        115                 120                 125             


Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro 
    130                 135                 140                 


Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu 
145                 150                 155                 160 


Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val 
                165                 170                 175     


Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu 
            180                 185                 190         


Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val 
        195                 200                 205             


Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys 
    210                 215                 220                 


Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Gln Gln Ser 
225                 230                 235                 240 


His Leu Gln Leu Leu Asn Ser Lys Ala Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly 
    


<210>  59
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  59

Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser 
1               5                   10                  15      


Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro 
            20                  25                  30          


Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val 
        35                  40                  45              


Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu 
    50                  55                  60                  


Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val 
65                  70                  75                  80  


Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp 
                85                  90                  95      


Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn 
            100                 105                 110         


Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn 
        115                 120                 125             


Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg 
    130                 135                 140                 


Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly 
145                 150                 155                 160 


Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu 
                165                 170                 175     


Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn 
            180                 185                 190         


Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly 
        195                 200                 205             


Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Gln Gln Ser His Leu Gln 
    210                 215                 220                 


Leu Leu Asn Ser Lys Ala Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460         


<210>  60
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  60

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu 
            20                  25                  30          


Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala 
        35                  40                  45              


Ser Gln Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser 
    50                  55                  60                  


Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu 
65                  70                  75                  80  


Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp 
                85                  90                  95      


Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys 
            100                 105                 110         


Ser Glu Pro Lys Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        115                 120                 125             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    130                 135                 140                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
145                 150                 155                 160 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                165                 170                 175     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            180                 185                 190         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        195                 200                 205             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    210                 215                 220                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
225                 230                 235                 240 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                245                 250                 255     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            260                 265                 270         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        275                 280                 285             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    290                 295                 300                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
305                 310                 315                 320 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                325                 330                 335     


Ser Leu Ser Leu Ser Pro Gly 
            340             


<210>  61
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  61

Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu 
1               5                   10                  15      


Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val 
            20                  25                  30          


Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu 
        35                  40                  45              


Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val 
    50                  55                  60                  


Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys 
65                  70                  75                  80  


Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Ser Glu Pro 
                85                  90                  95      


Lys Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            100                 105                 110         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        115                 120                 125             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    130                 135                 140                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
145                 150                 155                 160 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                165                 170                 175     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            180                 185                 190         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        195                 200                 205             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    210                 215                 220                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
225                 230                 235                 240 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                245                 250                 255     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            260                 265                 270         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        275                 280                 285             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    290                 295                 300                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
305                 310                 315                 320 


Leu Ser Pro Gly 
                


<210>  62
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  62

Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr 
1               5                   10                  15      


Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu Ala 
            20                  25                  30          


Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg 
        35                  40                  45              


Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asp Leu Val Asn 
    50                  55                  60                  


Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala Asn 
                85                  90                  95      


Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His Leu Tyr Ala Cys 
            100                 105                 110         


Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Ile Gly His 
        115                 120                 125             


His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser His Phe Glu Asn 
    130                 135                 140                 


Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu 
145                 150                 155                 160 


Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly 
                165                 170                 175     


Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg 
            180                 185                 190         


Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Lys Phe Ile Ser 
        195                 200                 205             


Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr 
    210                 215                 220                 


Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys Ala 
225                 230                 235                 240 


Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His 
                245                 250                 255     


Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
            260                 265                 270         


Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu 
        275                 280                 285             


Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys Asn Pro Val Val 
    290                 295                 300                 


Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val 
305                 310                 315                 320 


Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr 
                325                 330                 335     


Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg 
            340                 345                 350         


Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly 
        355                 360                 365             


Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg 
    370                 375                 380                 


Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met Asn Asn Arg Pro 
385                 390                 395                 400 


Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val 
                405                 410                 415     


Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly 
            420                 425                 430         


Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile Pro Lys Glu Thr 
        435                 440                 445             


Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg 
    450                 455                 460                 


Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln Gln 
465                 470                 475                 480 


Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu Pro Leu His Arg 
                485                 490                 495     


Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp 
            500                 505                 510         


Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg Tyr Phe Pro Thr 
        515                 520                 525             


Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro Leu 
    530                 535                 540                 


Thr His Cys Ser Asp Leu His His Asp Asn His His Gly His Ser Pro 
545                 550                 555                 560 


Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser Thr Phe Leu Glu 
                565                 570                 575     


Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp Gln Phe Gln Arg 
            580                 585                 590         


Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp Asp His Ile Ile 
        595                 600                 605             


Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln Gln Lys Asp Ser 
    610                 615                 620                 


Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe Ile Gln Thr Leu 
625                 630                 635                 640 


Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His Leu Glu Glu Leu 
                645                 650                 655     


Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr Lys Glu Met Ser 
            660                 665                 670         


Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg Asp Phe Met Gln 
        675                 680                 685             


Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu Phe Cys Glu Gln 
    690                 695                 700                 


Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg Pro Gly His Thr 
705                 710                 715                 720 


Pro Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu Asn Lys Lys Gly 
                725                 730                 735     


Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro Arg Ser Val 
            740                 745                 750     


<210>  63
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Gly Ile Lys 
                


<210>  64
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  64

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  65
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein

<400>  65

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  66
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein


<220>
<221>  MISC_FEATURE
<222>  (242)..(246)
<223>  Amino acids 242-246 are deleted.

<400>  66

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  67
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein


<220>
<221>  MISC_FEATURE
<222>  (238)..(246)
<223>  Amino acids 238-246 are deleted.

<400>  67

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  68
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein


<220>
<221>  MISC_FEATURE
<222>  (250)..(254)
<223>  Amino acids 250-254 are deleted.

<400>  68

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  69
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Amino acid 20 is deleted.

<220>
<221>  MISC_FEATURE
<222>  (142)..(241)
<223>  Amino acids 142-241 are deleted.

<220>
<221>  MISC_FEATURE
<222>  (473)..(473)
<223>  Amino acid 473 is deleted.

<400>  69

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  70
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Amino acid 20 is deleted.

<220>
<221>  MISC_FEATURE
<222>  (147)..(241)
<223>  Amino acids 147-241 are deleted.

<220>
<221>  MISC_FEATURE
<222>  (473)..(473)
<223>  Amino acid 473 is deleted.

<400>  70

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  71
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Amino acid 20 is deleted.

<220>
<221>  MISC_FEATURE
<222>  (151)..(241)
<223>  Amino acids 151-241 are deleted.

<220>
<221>  MISC_FEATURE
<222>  (473)..(473)
<223>  Amino acid 473 is deleted.

<400>  71

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  72
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein


<220>
<221>  MISC_FEATURE
<222>  (20)..(145)
<223>  Amino acids 20-145 are deleted.

<220>
<221>  MISC_FEATURE
<222>  (483)..(483)
<223>  Amino acid 483 is deleted.

<400>  72

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Gln Gln 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  73
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Amino acid 20 is deleted.

<220>
<221>  MISC_FEATURE
<222>  (258)..(260)
<223>  Amino acids 258-260 are deleted.

<220>
<221>  MISC_FEATURE
<222>  (483)..(483)
<223>  Amino acid 483 is deleted.

<400>  73

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Glu Ser Lys Tyr Gly 
                245                 250                 255     


Pro Lys Thr His Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  74
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fusion protein


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Amino acid 20 is deleted.

<220>
<221>  MISC_FEATURE
<222>  (483)..(483)
<223>  Amino acid 483 is deleted.

<400>  74

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Gln Gln 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Glu Pro Lys Ser Ser 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  75
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fragment of Nrp2

<400>  75

Val Asp Ile Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp Glu Ile 
1               5                   10                  15      


Asp Asp Glu Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala Thr Ser 
            20                  25                  30          


Gly Ser Gly Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu Tyr Thr 
        35                  40                  45              


Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val 
    50                  55                  60                  


Leu Leu Gly Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr Cys Ser 
65                  70                  75                  80  


Tyr Ser Gly Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn Tyr Asn 
                85                  90                  95      


Phe Glu Leu Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn His Gln 
            100                 105                 110         


Lys Cys Cys Ser Glu Ala 
        115             


<210>  76
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence fragment of Nrp2

<400>  76

Gly Gly Thr Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr Val Pro 
1               5                   10                  15      


Met Gln Pro Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala Gly Gly 
            20                  25                  30          


Ala Val Leu Val Leu Val Ser Val Ala Leu Ala Leu Val Leu His Tyr 
        35                  40                  45              


His Arg Phe Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile Thr Tyr 
    50                  55                  60                  


Lys Thr Ser His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu Pro Thr 
65                  70                  75                  80  


Leu Thr Ile Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
                85                  90              


<210>  77
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fragment of Nrp2

<400>  77

Val Asp Ile Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp Glu Ile 
1               5                   10                  15      


Asp Asp Glu Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala Thr Ser 
            20                  25                  30          


Gly Ser Gly Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu Tyr Thr 
        35                  40                  45              


Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val 
    50                  55                  60                  


Leu Leu Gly Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr Cys Ser 
65                  70                  75                  80  


Tyr Ser Gly Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn Tyr Asn 
                85                  90                  95      


Phe Glu Leu Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn His Gln 
            100                 105                 110         


Lys Cys Cys Ser Glu Ala 
        115             


<210>  78
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence fragment of Nrp2

<400>  78

Gly Gly Thr Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr Val Pro 
1               5                   10                  15      


Met Gln Pro Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala Gly Gly 
            20                  25                  30          


Ala Val Leu Val Leu Val Ser Val Ala Leu Ala Leu Val Leu His Tyr 
        35                  40                  45              


His Arg Phe Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile Thr Tyr 
    50                  55                  60                  


Lys Thr Ser His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu Pro Thr 
65                  70                  75                  80  


Leu Thr Ile Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
                85                  90              


<210>  79
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fragment of Nrp2

<400>  79

Val Asp Ile Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp Glu Ile 
1               5                   10                  15      


Asp Asp Glu Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala Thr Ser 
            20                  25                  30          


Gly Ser Gly Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu Tyr Thr 
        35                  40                  45              


Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val 
    50                  55                  60                  


Leu Leu Gly Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr Cys Ser 
65                  70                  75                  80  


Tyr Ser Gly Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn Tyr Asn 
                85                  90                  95      


Phe Glu Leu Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn His Gln 
            100                 105                 110         


Lys Cys Cys Ser Glu Ala 
        115             


<210>  80
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence fragment of Nrp2

<400>  80

Gly Gly Thr Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr Val Pro 
1               5                   10                  15      


Met Gln Pro Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala Gly Gly 
            20                  25                  30          


Ala Val Leu Val Leu Val Ser Val Ala Leu Ala Leu Val Leu His Tyr 
        35                  40                  45              


His Arg Phe Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile Thr Tyr 
    50                  55                  60                  


Lys Thr Ser His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu Pro Thr 
65                  70                  75                  80  


Leu Thr Ile Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
                85                  90              


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fragment of Nrp2

<400>  81

Leu Phe Glu Gly Asn Met His Tyr 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence fragment of Nrp2

<400>  82

Val Gly Cys Ser Trp Arg Pro Leu 
1               5               


<210>  83
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fragment of plexin4A

<400>  83

Ile Arg Val Asp Gly Pro Arg Gly Asn Ala Leu Gln Tyr Glu Thr Val 
1               5                   10                  15      


Gln Val Val Asp Pro Gly Pro Val Leu Arg Asp Met Ala Phe Ser Lys 
            20                  25                  30          


Asp His Glu Gln Leu Tyr Ile Met Ser Glu Arg Gln Leu Thr Arg Val 
        35                  40                  45              


Pro Val Glu Ser Cys Gly Gln Tyr Gln Ser Cys Gly Glu Cys Leu Gly 
    50                  55                  60                  


Ser 
65  


<210>  84
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence for fragment of 
       plexin4A

<400>  84

Ser Phe Gly Thr Gly Pro Gln Gly Gly Ile Thr Gln Glu Trp Ile Gly 
1               5                   10                  15      


Val Glu Gly Asp Pro Pro Gly Ala Asn Ile Ala Ser Gln Glu Gln Met 
            20                  25                  30          


Leu Cys Val Tyr Leu Gln Cys Ser Ser His Lys Ala Ile Ser Asp Gln 
        35                  40                  45              


Arg Val Gln Pro Leu Leu Cys Cys Phe Leu Asn Val Pro Gly Asn Ser 
    50                  55                  60                  


Ser 
65  


<210>  85
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fragment of plexin4A

<400>  85

Ile Arg Val Asp Gly Pro Arg Gly Asn Ala Leu Gln Tyr Glu Thr Val 
1               5                   10                  15      


Gln Val Val Asp Pro Gly Pro Val Leu Arg Asp Met Ala Phe Ser Lys 
            20                  25                  30          


Asp His Glu 
        35  


<210>  86
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence fragment of plexin4A

<400>  86

Met Pro Gly Thr Ser Leu Cys Pro Thr Leu Glu Leu Gln Thr Gly Pro 
1               5                   10                  15      


Arg Ser His Arg Ala Thr Val Thr Leu Glu Leu Leu Phe Ser Ser Cys 
            20                  25                  30          


Ser Ser Asn 
        35  


<210>  87
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fragment of plexin4A

<400>  87

Ile Arg Val Asp Gly Pro Arg Gly Asn Ala Leu Gln Tyr Glu Thr Val 
1               5                   10                  15      


Gln Val Val Asp Pro Gly Pro Val Leu Arg Asp Met Ala Phe Ser Lys 
            20                  25                  30          


Asp His Glu 
        35  


<210>  88
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence of fragment of 
       plexin4A

<400>  88

Met Pro Gly Thr Ser Leu Cys Pro Thr Leu Glu Leu Gln Thr Gly Pro 
1               5                   10                  15      


Arg Ser His Arg Ala Thr Val Thr Leu Glu Leu Leu Phe Ser Ser Cys 
            20                  25                  30          


Ser Ser Asn 
        35  


<210>  89
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - fragment of plexin4A

<400>  89

Ile Arg Val Asp Gly Pro Arg Gly Asn Ala Leu Gln Tyr Glu Thr Val 
1               5                   10                  15      


Gln Val Val Asp Pro Gly Pro Val Leu Arg Asp Met Ala Phe Ser Lys 
            20                  25                  30          


Asp His Glu Gln Leu Tyr Ile Met Ser Glu Arg Gln Leu Thr Arg Val 
        35                  40                  45              


Pro Val Glu Ser Cys Gly Gln Tyr Gln Ser Cys Gly Glu Cys Leu Gly 
    50                  55                  60                  


Ser 
65  


<210>  90
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence fragment of plexin4A

<400>  90

Ser Phe Gly Thr Gly Pro Gln Gly Gly Ile Thr Gln Glu Trp Ile Gly 
1               5                   10                  15      


Val Glu Gly Asp Pro Pro Gly Ala Asn Ile Ala Ser Gln Glu Gln Met 
            20                  25                  30          


Leu Cys Val Tyr Leu Gln Cys Ser Ser His Lys Ala Ile Ser Asp Gln 
        35                  40                  45              


Arg Val Gln Pro Leu Leu Cys Cys Phe Leu Asn Val Pro Gly Asn Ser 
    50                  55                  60                  


Ser 
65  


<210>  91
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence fragment of sema6C

<400>  91

Tyr Val Leu Pro Gly Pro Gly Pro Ser Pro Gly Thr Pro Ser Pro Pro 
1               5                   10                  15      


Ser Asp Ala His Pro Arg Pro Gln Ser Ser Thr Leu Gly Val His Thr 
            20                  25                  30          


Arg 
    


<210>  92
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence fragment of sema6C

<400>  92

Tyr Val Leu Pro Gly Pro Gly Pro Ser Pro Gly Thr Pro Ser Pro Pro 
1               5                   10                  15      


Ser Asp Ala His Pro Arg Pro Gln Ser Ser Thr Leu Gly Val His Thr 
            20                  25                  30          


Arg 
    


<210>  93
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - alternative sequence fragment of sema6C

<400>  93

Tyr Val Leu Pro Gly Pro Gly Pro Ser Pro Gly Thr Pro Ser Pro Pro 
1               5                   10                  15      


Ser Asp Ala His Pro Arg Pro Gln Ser Ser Thr Leu Gly Val His Thr 
            20                  25                  30          


Arg 
    


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide - linker

<400>  94

Ile Glu Gly Arg Met Asp 
1               5       


