                         SEQUENCE LISTING

<110>  Tufts University
 
<120>  Methods and compositions for prognosis, diagnosis and treatment 
       of ADAM8-expressing cancer

<130>  34724-129

<140>  PCT/US 14/
<141>  2014-05-13

<150>  61/822,738
<151>  2013-05-13

<150>  61/898,830
<151>  2013-11-01

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  1
cggcaccugc augacaacgu a                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and sythesized

<400>  2
cugcgcgaag cugcugacug a                                                 21


<210>  3
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and sythesized

<400>  3

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Arg Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Leu Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Thr Ala Pro 
            820                 


<210>  4
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  4

Pro Gly Pro Ala Glu Gly Ala Val Gly Pro Lys Val Ala Leu Lys Pro 
1               5                   10                  15      


Pro Ile Gln Arg Lys Gln Gly Ala Gly Ala Pro Thr Ala Pro 
            20                  25                  30  


<210>  5
<211>  61
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  5

Pro Val Tyr Thr Arg Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe 
1               5                   10                  15      


Ala Pro Pro Val Pro Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro 
            20                  25                  30          


Gly Pro Ala Glu Gly Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro 
        35                  40                  45              


Ile Gln Arg Lys Gln Gly Ala Gly Ala Pro Thr Ala Pro 
    50                  55                  60      


<210>  6
<211>  155
<212>  PRT
<213>  Mus musculus

<400>  6

Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala Gln Gln 
1               5                   10                  15      


Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu Ser Cys 
            20                  25                  30          


Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr Arg Ala 
        35                  40                  45              


Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro Leu Gly 
    50                  55                  60                  


Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr Glu Asp 
65                  70                  75                  80  


Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly Pro Glu 
                85                  90                  95      


Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr Arg Ser 
            100                 105                 110         


Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn His Lys 
        115                 120                 125             


Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys Ala Lys 
    130                 135                 140                 


Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser 
145                 150                 155 


<210>  7
<211>  495
<212>  PRT
<213>  Capra hicus

<400>  7

His Leu Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu 
1               5                   10                  15      


Gly Ser Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro 
            20                  25                  30          


Gly Asp Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val 
        35                  40                  45              


Val Val Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val 
    50                  55                  60                  


Arg His Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln 
65                  70                  75                  80  


Lys Leu Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser 
                85                  90                  95      


Gln Asp Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn 
            100                 105                 110         


Leu Leu Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp 
        115                 120                 125             


Asn Val Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly 
    130                 135                 140                 


Phe Ala Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn 
145                 150                 155                 160 


Gln Asp His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His 
                165                 170                 175     


Glu Met Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly 
            180                 185                 190         


Cys Arg Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly 
        195                 200                 205             


Ser Ile Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala 
    210                 215                 220                 


Tyr Leu Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn 
225                 230                 235                 240 


Ala Pro Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu 
                245                 250                 255     


Phe Val Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys 
            260                 265                 270         


Arg Asn Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala 
        275                 280                 285             


Gln Cys Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala 
    290                 295                 300                 


Gly Glu Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe 
305                 310                 315                 320 


Cys Asp Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn 
                325                 330                 335     


Gly Thr Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr 
            340                 345                 350         


Leu Ala Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala 
        355                 360                 365             


Glu Glu Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser 
    370                 375                 380                 


Arg Tyr Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln 
385                 390                 395                 400 


Gln Pro Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu 
                405                 410                 415     


Thr Thr Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg 
            420                 425                 430         


Cys Gly Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His 
        435                 440                 445             


Val Tyr Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val 
    450                 455                 460                 


Cys Asn His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro 
465                 470                 475                 480 


His Cys Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser 
                485                 490                 495 


<210>  8
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  8
gcggcaccug caugacaacg uacagcuca                                         29


<210>  9
<211>  298
<212>  PRT
<213>  Mus musculus

<400>  9

Tyr Val Glu Leu Tyr Val Val Val Asp Asn Ala Glu Phe Gln Met Leu 
1               5                   10                  15      


Gly Ser Glu Ala Ala Val Arg His Arg Val Leu Glu Val Val Asn His 
            20                  25                  30          


Val Asp Lys Leu Tyr Gln Lys Leu Asn Phe Arg Val Val Leu Val Gly 
        35                  40                  45              


Leu Glu Ile Trp Asn Ser Gln Asp Arg Phe His Val Ser Pro Asp Pro 
    50                  55                  60                  


Ser Val Thr Leu Glu Asn Leu Leu Thr Trp Gln Ala Arg Gln Arg Thr 
65                  70                  75                  80  


Arg Arg His Leu His Asp Asn Val Gln Leu Ile Thr Gly Val Asp Phe 
                85                  90                  95      


Thr Gly Thr Thr Val Gly Phe Ala Arg Val Ser Ala Met Cys Ser His 
            100                 105                 110         


Ser Ser Gly Ala Val Asn Gln Asp His Ser Lys Asn Pro Val Gly Val 
        115                 120                 125             


Ala Cys Thr Met Ala His Glu Met Gly His Asn Leu Gly Met Asp His 
    130                 135                 140                 


Asp Glu Asn Val Gln Gly Cys Arg Cys Gln Glu Arg Phe Glu Ala Gly 
145                 150                 155                 160 


Arg Cys Ile Met Ala Gly Ser Ile Gly Ser Ser Phe Pro Arg Met Phe 
                165                 170                 175     


Ser Asp Cys Ser Gln Ala Tyr Leu Glu Ser Phe Leu Glu Arg Pro Gln 
            180                 185                 190         


Ser Val Cys Leu Ala Asn Ala Pro Asp Leu Ser His Leu Val Gly Gly 
        195                 200                 205             


Pro Val Cys Gly Asn Leu Phe Val Glu Arg Gly Glu Gln Cys Asp Cys 
    210                 215                 220                 


Gly Pro Pro Glu Asp Cys Arg Asn Arg Cys Cys Asn Ser Thr Thr Cys 
225                 230                 235                 240 


Gln Leu Ala Glu Gly Ala Gln Cys Ala His Gly Thr Cys Cys Gln Glu 
                245                 250                 255     


Cys Lys Val Lys Pro Ala Gly Glu Leu Cys Arg Pro Lys Lys Asp Met 
            260                 265                 270         


Cys Asp Leu Glu Glu Phe Cys Asp Gly Arg His Pro Glu Cys Pro Glu 
        275                 280                 285             


Asp Ala Phe Gln Glu Asn Gly Thr Pro Cys 
    290                 295             


