                         SEQUENCE LISTING

<110>  GlobeImmune, Inc.
       The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
       Rodell, Timothy C.
       Apelian, David
       Palena, Claudia
       Schlom, Jeffrey
 
<120>  Yeast-Based Immunotherapy for Chordoma

<130>  7797-2-PCT

<140>  Not Yet Assigned
<141>  2014-03-14

<150>  61/803,332
<151>  2013-03-19

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  2518
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (494)..(1801)

<400>  1
tttgcttttg cttatttccg tccatttccc tctctgcgcg cggaccttcc ttttccagat       60

ggtgagagcc gcggggacac ccgacgccgg ggcaggctga tccacgatcc tgggtgtgcg      120

taacgccgcc tggggctccg tgggcgaggg acgtgtgggg acaggtgcac cggaaactgc      180

cagactggag agttgaggca tcggaggcgc gagaacagca ctactactgc ggcgagacga      240

gcgcggcgca tcccaaagcc cggccaaatg cgctcgtccc tgggagggga gggaggcgcg      300

cctggagcgg ggacagtctt ggtccgcgcc ctcctcccgg gtctgtgccg ggacccggga      360

cccgggagcc gtcgcaggtc tcggtccaag gggccccttt tctcggaagg gcggcggcca      420

agagcaggga aggtggatct caggtagcga gtctgggctt cggggacggc ggggagggga      480

gccggacggg agg atg agc tcc cct ggc acc gag agc gcg gga aag agc         529
               Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser            
               1               5                   10                     

ctg cag tac cga gtg gac cac ctg ctg agc gcc gtg gag aat gag ctg        577
Leu Gln Tyr Arg Val Asp His Leu Leu Ser Ala Val Glu Asn Glu Leu           
        15                  20                  25                        

cag gcg ggc agc gag aag ggc gac ccc aca gag cgc gaa ctg cgc gtg        625
Gln Ala Gly Ser Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg Val           
    30                  35                  40                            

ggc ctg gag gag agc gag ctg tgg ctg cgc ttc aag gag ctc acc aat        673
Gly Leu Glu Glu Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn           
45                  50                  55                  60            

gag atg atc gtg acc aag aac ggc agg agg atg ttt ccg gtg ctg aag        721
Glu Met Ile Val Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys           
                65                  70                  75                

gtg aac gtg tct ggc ctg gac ccc aac gcc atg tac tcc ttc ctg ctg        769
Val Asn Val Ser Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu           
            80                  85                  90                    

gac ttc gtg gcg gcg gac aac cac cgc tgg aag tac gtg aac ggg gaa        817
Asp Phe Val Ala Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu           
        95                  100                 105                       

tgg gtg ccg ggg ggc aag ccg gag ccg cag gcg ccc agc tgc gtc tac        865
Trp Val Pro Gly Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val Tyr           
    110                 115                 120                           

atc cac ccc gac tcg ccc aac ttc ggg gcc cac tgg atg aag gct ccc        913
Ile His Pro Asp Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro           
125                 130                 135                 140           

gtc tcc ttc agc aaa gtc aag ctc acc aac aag ctc aac gga ggg ggc        961
Val Ser Phe Ser Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly           
                145                 150                 155               

cag atc atg ctg aac tcc ttg cat aag tat gag cct cga atc cac ata       1009
Gln Ile Met Leu Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile           
            160                 165                 170                   

gtg aga gtt ggg ggt cca cag cgc atg atc acc agc cac tgc ttc cct       1057
Val Arg Val Gly Gly Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro           
        175                 180                 185                       

gag acc cag ttc ata gcg gtg act gct tat cag aac gag gag atc aca       1105
Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr           
    190                 195                 200                           

gct ctt aaa att aag tac aat cca ttt gca aaa gct ttc ctt gat gca       1153
Ala Leu Lys Ile Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala           
205                 210                 215                 220           

aag gaa aga agt gat cac aaa gag atg atg gag gaa ccc gga gac agc       1201
Lys Glu Arg Ser Asp His Lys Glu Met Met Glu Glu Pro Gly Asp Ser           
                225                 230                 235               

cag caa cct ggg tac tcc caa tgg ggg tgg ctt ctt cct gga acc agc       1249
Gln Gln Pro Gly Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr Ser           
            240                 245                 250                   

acc ctg tgt cca cct gca aat cct cat cct cag ttt gga ggt gcc ctc       1297
Thr Leu Cys Pro Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala Leu           
        255                 260                 265                       

tcc ctc ccc tcc acg cac agc tgt gac agg tac cca acc ctg agg agc       1345
Ser Leu Pro Ser Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg Ser           
    270                 275                 280                           

cac cgg tcc tca ccc tac ccc agc ccc tat gct cat cgg aac aat tct       1393
His Arg Ser Ser Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn Ser           
285                 290                 295                 300           

cca acc tat tct gac aac tca cct gca tgt tta tcc atg ctg caa tcc       1441
Pro Thr Tyr Ser Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln Ser           
                305                 310                 315               

cat gac aat tgg tcc agc ctt gga atg cct gcc cat ccc agc atg ctc       1489
His Asp Asn Trp Ser Ser Leu Gly Met Pro Ala His Pro Ser Met Leu           
            320                 325                 330                   

ccc gtg agc cac aat gcc agc cca cct acc agc tcc agt cag tac ccc       1537
Pro Val Ser His Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr Pro           
        335                 340                 345                       

agc ctg tgg tct gtg agc aac ggc gcc gtc acc ccg ggc tcc cag gca       1585
Ser Leu Trp Ser Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln Ala           
    350                 355                 360                           

gca gcc gtg tcc aac ggg ctg ggg gcc cag ttc ttc cgg ggc tcc ccc       1633
Ala Ala Val Ser Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro           
365                 370                 375                 380           

gcg cac tac aca ccc ctc acc cat ccg gtc tcg gcg ccc tct tcc tcg       1681
Ala His Tyr Thr Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser Ser           
                385                 390                 395               

gga tcc cca ctg tac gaa ggg gcg gcc gcg gcc aca gac atc gtg gac       1729
Gly Ser Pro Leu Tyr Glu Gly Ala Ala Ala Ala Thr Asp Ile Val Asp           
            400                 405                 410                   

agc cag tac gac gcc gca gcc caa ggc cgc ctc ata gcc tca tgg aca       1777
Ser Gln Tyr Asp Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp Thr           
        415                 420                 425                       

cct gtg tcg cca cct tcc atg tga agcagcaagg cccaggtccc gaaagatgca      1831
Pro Val Ser Pro Pro Ser Met                                               
    430                 435                                               

gtgacttttt gtcgtggcag ccagtggtga ctggattgac ctactaggta cccagtggca     1891

gtctcaggtt aagaaggaaa tgcagcctca gtaacttcct tttcaaagca gtggaggagc     1951

acacggcacc tttccccaga gccccagcat cccttgctca cacctgcagt agcggtgctg     2011

tcccaggtgg cttacagatg aacccaactg tggagatgat gcagttggcc caacctcact     2071

gacggtgaaa aaatgtttgc cagggtccag aaactttttt tggtttattt ctcatacagt     2131

gtattggcaa ctttggcaca ccagaatttg taaactccac cagtcctact ttagtgagat     2191

aaaaagcaca ctcttaatct tcttccttgt tgctttcaag tagttagagt tgagctgtta     2251

aggacagaat aaaatcatag ttgaggacag caggttttag ttgaattgaa aatttgactg     2311

ctctgccccc tagaatgtgt gtattttaag catatgtagc taatctcttg tgttgttaaa     2371

ctataactgt ttcatatttt tcttttgaca aagtagccaa agacaatcag cagaaagcat     2431

tttctgcaaa ataaacgcaa tatgcaaaat gtgattcgtc cagttattag tgaagcccct     2491

ccttttgtga gtatttactg tttattg                                         2518


<210>  2
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser Leu Gln Tyr Arg 
1               5                   10                  15      


Val Asp His Leu Leu Ser Ala Val Glu Asn Glu Leu Gln Ala Gly Ser 
            20                  25                  30          


Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg Val Gly Leu Glu Glu 
        35                  40                  45              


Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn Glu Met Ile Val 
    50                  55                  60                  


Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys Val Asn Val Ser 
65                  70                  75                  80  


Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu Asp Phe Val Ala 
                85                  90                  95      


Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu Trp Val Pro Gly 
            100                 105                 110         


Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val Tyr Ile His Pro Asp 
        115                 120                 125             


Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro Val Ser Phe Ser 
    130                 135                 140                 


Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly Gln Ile Met Leu 
145                 150                 155                 160 


Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile Val Arg Val Gly 
                165                 170                 175     


Gly Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro Glu Thr Gln Phe 
            180                 185                 190         


Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr Ala Leu Lys Ile 
        195                 200                 205             


Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala Lys Glu Arg Ser 
    210                 215                 220                 


Asp His Lys Glu Met Met Glu Glu Pro Gly Asp Ser Gln Gln Pro Gly 
225                 230                 235                 240 


Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr Ser Thr Leu Cys Pro 
                245                 250                 255     


Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala Leu Ser Leu Pro Ser 
            260                 265                 270         


Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg Ser His Arg Ser Ser 
        275                 280                 285             


Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn Ser Pro Thr Tyr Ser 
    290                 295                 300                 


Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln Ser His Asp Asn Trp 
305                 310                 315                 320 


Ser Ser Leu Gly Met Pro Ala His Pro Ser Met Leu Pro Val Ser His 
                325                 330                 335     


Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr Pro Ser Leu Trp Ser 
            340                 345                 350         


Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln Ala Ala Ala Val Ser 
        355                 360                 365             


Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro Ala His Tyr Thr 
    370                 375                 380                 


Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser Ser Gly Ser Pro Leu 
385                 390                 395                 400 


Tyr Glu Gly Ala Ala Ala Ala Thr Asp Ile Val Asp Ser Gln Tyr Asp 
                405                 410                 415     


Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp Thr Pro Val Ser Pro 
            420                 425                 430         


Pro Ser Met 
        435 


<210>  3
<211>  2046
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (109)..(1419)

<400>  3
ggctccgcag agtgaccctt tttcttggaa aagcggtggc gagagaagtg aaggtggctg       60

ttgggtaggg agtcaagact cctggaaggt ggagagggtg gcgggagg atg agc tcg       117
                                                     Met Ser Ser          
                                                     1                    

ccg ggc aca gag agc gca ggg aag agc ctg cag tac cga gtg gac cac        165
Pro Gly Thr Glu Ser Ala Gly Lys Ser Leu Gln Tyr Arg Val Asp His           
    5                   10                  15                            

ctg ctc agc gcc gtg gag agc gag ctg cag gcg ggc agc gag aag gga        213
Leu Leu Ser Ala Val Glu Ser Glu Leu Gln Ala Gly Ser Glu Lys Gly           
20                  25                  30                  35            

gac ccc acc gaa cgc gaa ctg cga gtg ggc ctg gag gag agc gag ctg        261
Asp Pro Thr Glu Arg Glu Leu Arg Val Gly Leu Glu Glu Ser Glu Leu           
                40                  45                  50                

tgg ctg cgc ttc aag gag cta act aac gag atg att gtg acc aag aac        309
Trp Leu Arg Phe Lys Glu Leu Thr Asn Glu Met Ile Val Thr Lys Asn           
            55                  60                  65                    

ggc agg agg atg ttc ccg gtg ctg aag gta aat gtg tca ggc ctg gac        357
Gly Arg Arg Met Phe Pro Val Leu Lys Val Asn Val Ser Gly Leu Asp           
        70                  75                  80                        

ccc aat gcc atg tac tct ttc ttg ctg gac ttc gtg acg gct gac aac        405
Pro Asn Ala Met Tyr Ser Phe Leu Leu Asp Phe Val Thr Ala Asp Asn           
    85                  90                  95                            

cac cgc tgg aaa tat gtg aac ggg gag tgg gta cct ggg ggc aaa cca        453
His Arg Trp Lys Tyr Val Asn Gly Glu Trp Val Pro Gly Gly Lys Pro           
100                 105                 110                 115           

gag cct cag gcg ccc agc tgc gtc tac atc cac cca gac tcg ccc aat        501
Glu Pro Gln Ala Pro Ser Cys Val Tyr Ile His Pro Asp Ser Pro Asn           
                120                 125                 130               

ttt ggg gcc cac tgg atg aag gcg cct gtg tct ttc agc aaa gtc aaa        549
Phe Gly Ala His Trp Met Lys Ala Pro Val Ser Phe Ser Lys Val Lys           
            135                 140                 145                   

ctc acc aac aag ctc aat gga ggg gga cag atc atg tta aac tcc ttg        597
Leu Thr Asn Lys Leu Asn Gly Gly Gly Gln Ile Met Leu Asn Ser Leu           
        150                 155                 160                       

cat aag tat gaa cct cgg att cac atc gtg aga gtt ggg ggc ccg caa        645
His Lys Tyr Glu Pro Arg Ile His Ile Val Arg Val Gly Gly Pro Gln           
    165                 170                 175                           

cgc atg atc acc agc cac tgc ttt ccc gag acc cag ttc ata gct gtg        693
Arg Met Ile Thr Ser His Cys Phe Pro Glu Thr Gln Phe Ile Ala Val           
180                 185                 190                 195           

act gcc tac cag aat gag gag att aca gcc ctt aaa att aaa tac aac        741
Thr Ala Tyr Gln Asn Glu Glu Ile Thr Ala Leu Lys Ile Lys Tyr Asn           
                200                 205                 210               

cca ttt gct aaa gcc ttc ctt gat gcc aaa gaa aga aac gac cac aaa        789
Pro Phe Ala Lys Ala Phe Leu Asp Ala Lys Glu Arg Asn Asp His Lys           
            215                 220                 225                   

gat gta atg gag gaa ccg ggg gac tgc cag cag ccg ggg tat tcc caa        837
Asp Val Met Glu Glu Pro Gly Asp Cys Gln Gln Pro Gly Tyr Ser Gln           
        230                 235                 240                       

tgg ggg tgg ctt gtt cct ggt gct ggc acc ctc tgc ccg cct gcc agc        885
Trp Gly Trp Leu Val Pro Gly Ala Gly Thr Leu Cys Pro Pro Ala Ser           
    245                 250                 255                           

tcc cac cct cag ttt gga ggc tcg ctc tct ctc ccc tcc aca cac ggc        933
Ser His Pro Gln Phe Gly Gly Ser Leu Ser Leu Pro Ser Thr His Gly           
260                 265                 270                 275           

tgt gag agg tac cca gct cta agg aac cac cgg tca tcg ccc tac ccc        981
Cys Glu Arg Tyr Pro Ala Leu Arg Asn His Arg Ser Ser Pro Tyr Pro           
                280                 285                 290               

agc ccc tat gct cat cgg aac agc tct cca acc tat gcg gac aat tca       1029
Ser Pro Tyr Ala His Arg Asn Ser Ser Pro Thr Tyr Ala Asp Asn Ser           
            295                 300                 305                   

tct gct tgt ctg tcc atg ctg cag tcc cat gat aac tgg tct agc ctc       1077
Ser Ala Cys Leu Ser Met Leu Gln Ser His Asp Asn Trp Ser Ser Leu           
        310                 315                 320                       

gga gtg cct ggc cac acc agc atg ctg cct gtg agt cat aac gcc agc       1125
Gly Val Pro Gly His Thr Ser Met Leu Pro Val Ser His Asn Ala Ser           
    325                 330                 335                           

cca cct act ggc tct agc cag tat ccc agt ctc tgg tct gtg agc aat       1173
Pro Pro Thr Gly Ser Ser Gln Tyr Pro Ser Leu Trp Ser Val Ser Asn           
340                 345                 350                 355           

ggt acc atc acc cca ggc tcc cag aca gct ggg gtg tcc aac ggg ctg       1221
Gly Thr Ile Thr Pro Gly Ser Gln Thr Ala Gly Val Ser Asn Gly Leu           
                360                 365                 370               

gga gct cag ttc ttt cga ggc tcc cct gca cat tac aca cca ctg acg       1269
Gly Ala Gln Phe Phe Arg Gly Ser Pro Ala His Tyr Thr Pro Leu Thr           
            375                 380                 385                   

cac acg gtc tca gct gcc acg tcc tcg tct tct ggt tct ccg atg tat       1317
His Thr Val Ser Ala Ala Thr Ser Ser Ser Ser Gly Ser Pro Met Tyr           
        390                 395                 400                       

gaa ggg gct gct aca gtc aca gac att tct gac agc cag tat gac acg       1365
Glu Gly Ala Ala Thr Val Thr Asp Ile Ser Asp Ser Gln Tyr Asp Thr           
    405                 410                 415                           

gcc caa agc ctc ctc ata gcc tcg tgg aca cct gtg tca ccc cca tct       1413
Ala Gln Ser Leu Leu Ile Ala Ser Trp Thr Pro Val Ser Pro Pro Ser           
420                 425                 430                 435           

atg tga attgaacttt cctccatgtg ctgagacttg taacaaccgg tgtcaactgg        1469
Met                                                                       
                                                                          

atcttctagg ctcaaagtgg caggctcttg ggacaaggga aaaataaata aataaaagct     1529

agatactaac aactccattt tcaaataaga gcaataatac atgtcctata atcatgttct     1589

acagcctctt gtttgatacc tacagtagtg atatgtgtcc tacattatga agccaaggac     1649

agagagacgg ctgtggtcca gttttttgtg actggcagtt aatcagagtc ctttgctagg     1709

tagggtccta tatcttgtgt ttctctacaa catatatgtg actttgaaat cctggaattc     1769

gtccaccccc tgtcctactt tagtgagaca caaggtacac ctctaatgtc ctcccttgtt     1829

gccttagagt agttaacttt gaggacagaa aaaagcatag ccagaagatt gtaactgaac     1889

cgtcaactgt tctgcccttg gaacatgcct actttaagca cacgtagctt tttgtgttgg     1949

gaagtcaact gtatggatac ttttctgttg acaaagtagc caaagacaat ctgcagaaag     2009

tgttttctgc acaataaagg caatatatag cacctgg                              2046


<210>  4
<211>  436
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser Leu Gln Tyr Arg 
1               5                   10                  15      


Val Asp His Leu Leu Ser Ala Val Glu Ser Glu Leu Gln Ala Gly Ser 
            20                  25                  30          


Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg Val Gly Leu Glu Glu 
        35                  40                  45              


Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn Glu Met Ile Val 
    50                  55                  60                  


Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys Val Asn Val Ser 
65                  70                  75                  80  


Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu Asp Phe Val Thr 
                85                  90                  95      


Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu Trp Val Pro Gly 
            100                 105                 110         


Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val Tyr Ile His Pro Asp 
        115                 120                 125             


Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro Val Ser Phe Ser 
    130                 135                 140                 


Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly Gln Ile Met Leu 
145                 150                 155                 160 


Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile Val Arg Val Gly 
                165                 170                 175     


Gly Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro Glu Thr Gln Phe 
            180                 185                 190         


Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr Ala Leu Lys Ile 
        195                 200                 205             


Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala Lys Glu Arg Asn 
    210                 215                 220                 


Asp His Lys Asp Val Met Glu Glu Pro Gly Asp Cys Gln Gln Pro Gly 
225                 230                 235                 240 


Tyr Ser Gln Trp Gly Trp Leu Val Pro Gly Ala Gly Thr Leu Cys Pro 
                245                 250                 255     


Pro Ala Ser Ser His Pro Gln Phe Gly Gly Ser Leu Ser Leu Pro Ser 
            260                 265                 270         


Thr His Gly Cys Glu Arg Tyr Pro Ala Leu Arg Asn His Arg Ser Ser 
        275                 280                 285             


Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Ser Ser Pro Thr Tyr Ala 
    290                 295                 300                 


Asp Asn Ser Ser Ala Cys Leu Ser Met Leu Gln Ser His Asp Asn Trp 
305                 310                 315                 320 


Ser Ser Leu Gly Val Pro Gly His Thr Ser Met Leu Pro Val Ser His 
                325                 330                 335     


Asn Ala Ser Pro Pro Thr Gly Ser Ser Gln Tyr Pro Ser Leu Trp Ser 
            340                 345                 350         


Val Ser Asn Gly Thr Ile Thr Pro Gly Ser Gln Thr Ala Gly Val Ser 
        355                 360                 365             


Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro Ala His Tyr Thr 
    370                 375                 380                 


Pro Leu Thr His Thr Val Ser Ala Ala Thr Ser Ser Ser Ser Gly Ser 
385                 390                 395                 400 


Pro Met Tyr Glu Gly Ala Ala Thr Val Thr Asp Ile Ser Asp Ser Gln 
                405                 410                 415     


Tyr Asp Thr Ala Gln Ser Leu Leu Ile Ala Ser Trp Thr Pro Val Ser 
            420                 425                 430         


Pro Pro Ser Met 
        435     


<210>  5
<211>  1305
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1305)

<400>  5
atg agc tcc cct ggc acc gag agc gcg gga aag agc ctg cag tac cga         48
Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser Leu Gln Tyr Arg           
1               5                   10                  15                

gtg gac cac ctg ctg agc gcc gtg gag aat gag ctg cag gcg ggc agc         96
Val Asp His Leu Leu Ser Ala Val Glu Asn Glu Leu Gln Ala Gly Ser           
            20                  25                  30                    

gag aag ggc gac ccc aca gag cgc gaa ctg cgc gtg ggc ctg gag gag        144
Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg Val Gly Leu Glu Glu           
        35                  40                  45                        

agc gag ctg tgg ctg cgc ttc aag gag ctc acc aat gag atg atc gtg        192
Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn Glu Met Ile Val           
    50                  55                  60                            

acc aag aac ggc agg agg atg ttt ccg gtg ctg aag gtg aac gtg tct        240
Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys Val Asn Val Ser           
65                  70                  75                  80            

ggc ctg gac ccc aac gcc atg tac tcc ttc ctg ctg gac ttc gtg gcg        288
Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu Asp Phe Val Ala           
                85                  90                  95                

gcg gac aac cac cgc tgg aag tac gtg aac ggg gaa tgg gtg ccg ggg        336
Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu Trp Val Pro Gly           
            100                 105                 110                   

ggc aag ccg gag ccg cag gcg ccc agc tgc gtc tac atc cac ccc gac        384
Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val Tyr Ile His Pro Asp           
        115                 120                 125                       

tcg ccc aac ttc ggg gcc cac tgg atg aag gct ccc gtc tcc ttc agc        432
Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro Val Ser Phe Ser           
    130                 135                 140                           

aaa gtc aag ctc acc aac aag ctc aac gga ggg ggc cag atc atg ctg        480
Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly Gln Ile Met Leu           
145                 150                 155                 160           

aac tcc ttg cat aag tat gag cct cga atc cac ata gtg aga gtt ggg        528
Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile Val Arg Val Gly           
                165                 170                 175               

gat cca cag cgc atg atc acc agc cac tgc ttc cct gag acc cag ttc        576
Asp Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro Glu Thr Gln Phe           
            180                 185                 190                   

ata gcg gtg act gct tat cag aac gag gag atc aca gct ctt aaa att        624
Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr Ala Leu Lys Ile           
        195                 200                 205                       

aag tac aat cca ttt gca aaa gct ttc ctt gat gca aag gaa aga agt        672
Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala Lys Glu Arg Ser           
    210                 215                 220                           

gat cac aaa gag atg atg gag gaa ccc gga gac agc cag caa cct ggg        720
Asp His Lys Glu Met Met Glu Glu Pro Gly Asp Ser Gln Gln Pro Gly           
225                 230                 235                 240           

tac tcc caa tgg ggg tgg ctt ctt cct gga acc agc acc ctg tgt cca        768
Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr Ser Thr Leu Cys Pro           
                245                 250                 255               

cct gca aat cct cat cct cag ttt gga ggt gcc ctc tcc ctc ccc tcc        816
Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala Leu Ser Leu Pro Ser           
            260                 265                 270                   

acg cac agc tgt gac agg tac cca acc ctg agg agc cac cgg tcc tca        864
Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg Ser His Arg Ser Ser           
        275                 280                 285                       

ccc tac ccc agc ccc tat gct cat cgg aac aat tct cca acc tat tct        912
Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn Ser Pro Thr Tyr Ser           
    290                 295                 300                           

gac aac tca cct gca tgt tta tcc atg ctg caa tcc cat gac aat tgg        960
Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln Ser His Asp Asn Trp           
305                 310                 315                 320           

tcc agc ctt gga atg cct gcc cat ccc agc atg ctc ccc gtg agc cac       1008
Ser Ser Leu Gly Met Pro Ala His Pro Ser Met Leu Pro Val Ser His           
                325                 330                 335               

aat gcc agc cca cct acc agc tcc agt cag tac ccc agc ctg tgg tct       1056
Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr Pro Ser Leu Trp Ser           
            340                 345                 350                   

gtg agc aac ggc gcc gtc acc ccg ggc tcc cag gca gca gcc gtg acc       1104
Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln Ala Ala Ala Val Thr           
        355                 360                 365                       

aac ggg ctg ggg gcc cag ttc ttc cgg ggc tcc ccc gcg cac tac aca       1152
Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro Ala His Tyr Thr           
    370                 375                 380                           

ccc ctc acc cat ccg gtc tcg gca ccc tct tcc tcg gga tcc cca ctg       1200
Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser Ser Gly Ser Pro Leu           
385                 390                 395                 400           

tac gaa ggg gcg gcc gcg gcc aca aac atc gtg gac agc cag tac gac       1248
Tyr Glu Gly Ala Ala Ala Ala Thr Asn Ile Val Asp Ser Gln Tyr Asp           
                405                 410                 415               

gcc gca gcc caa ggc cgc ctc ata gcc tca tgg aca cct gtg tcg cca       1296
Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp Thr Pro Val Ser Pro           
            420                 425                 430                   

cct tcc atg                                                           1305
Pro Ser Met                                                               
        435                                                               


<210>  6
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser Leu Gln Tyr Arg 
1               5                   10                  15      


Val Asp His Leu Leu Ser Ala Val Glu Asn Glu Leu Gln Ala Gly Ser 
            20                  25                  30          


Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg Val Gly Leu Glu Glu 
        35                  40                  45              


Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn Glu Met Ile Val 
    50                  55                  60                  


Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys Val Asn Val Ser 
65                  70                  75                  80  


Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu Asp Phe Val Ala 
                85                  90                  95      


Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu Trp Val Pro Gly 
            100                 105                 110         


Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val Tyr Ile His Pro Asp 
        115                 120                 125             


Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro Val Ser Phe Ser 
    130                 135                 140                 


Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly Gln Ile Met Leu 
145                 150                 155                 160 


Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile Val Arg Val Gly 
                165                 170                 175     


Asp Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro Glu Thr Gln Phe 
            180                 185                 190         


Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr Ala Leu Lys Ile 
        195                 200                 205             


Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala Lys Glu Arg Ser 
    210                 215                 220                 


Asp His Lys Glu Met Met Glu Glu Pro Gly Asp Ser Gln Gln Pro Gly 
225                 230                 235                 240 


Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr Ser Thr Leu Cys Pro 
                245                 250                 255     


Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala Leu Ser Leu Pro Ser 
            260                 265                 270         


Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg Ser His Arg Ser Ser 
        275                 280                 285             


Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn Ser Pro Thr Tyr Ser 
    290                 295                 300                 


Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln Ser His Asp Asn Trp 
305                 310                 315                 320 


Ser Ser Leu Gly Met Pro Ala His Pro Ser Met Leu Pro Val Ser His 
                325                 330                 335     


Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr Pro Ser Leu Trp Ser 
            340                 345                 350         


Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln Ala Ala Ala Val Thr 
        355                 360                 365             


Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro Ala His Tyr Thr 
    370                 375                 380                 


Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser Ser Gly Ser Pro Leu 
385                 390                 395                 400 


Tyr Glu Gly Ala Ala Ala Ala Thr Asn Ile Val Asp Ser Gln Tyr Asp 
                405                 410                 415     


Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp Thr Pro Val Ser Pro 
            420                 425                 430         


Pro Ser Met 
        435 


<210>  7
<211>  1357
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (10)..(1347)

<400>  7
gaattccgc atg gcc gat gaa gct ccg agc tcc cct ggc acc gag agc gcg       51
          Met Ala Asp Glu Ala Pro Ser Ser Pro Gly Thr Glu Ser Ala         
          1               5                   10                          

gga aag agc ctg cag tac cga gtg gac cac ctg ctg agc gcc gtg gag         99
Gly Lys Ser Leu Gln Tyr Arg Val Asp His Leu Leu Ser Ala Val Glu           
15                  20                  25                  30            

aat gag ctg cag gcg ggc agc gag aag ggc gac ccc aca gag cgc gaa        147
Asn Glu Leu Gln Ala Gly Ser Glu Lys Gly Asp Pro Thr Glu Arg Glu           
                35                  40                  45                

ctg cgc gtg ggc ctg gag gag agc gag ctg tgg ctg cgc ttc aag gag        195
Leu Arg Val Gly Leu Glu Glu Ser Glu Leu Trp Leu Arg Phe Lys Glu           
            50                  55                  60                    

ctc acc aat gag atg atc gtg acc aag aac ggc agg agg atg ttt ccg        243
Leu Thr Asn Glu Met Ile Val Thr Lys Asn Gly Arg Arg Met Phe Pro           
        65                  70                  75                        

gtg ctg aag gtg aac gtg tct ggc ctg gac ccc aac gcc atg tac tcc        291
Val Leu Lys Val Asn Val Ser Gly Leu Asp Pro Asn Ala Met Tyr Ser           
    80                  85                  90                            

ttc ctg ctg gac ttc gtg gcg gcg gac aac cac cgc tgg aag tac gtg        339
Phe Leu Leu Asp Phe Val Ala Ala Asp Asn His Arg Trp Lys Tyr Val           
95                  100                 105                 110           

aac ggg gaa tgg gtg ccg ggg ggc aag ccg gag ccg cag gcg ccc agc        387
Asn Gly Glu Trp Val Pro Gly Gly Lys Pro Glu Pro Gln Ala Pro Ser           
                115                 120                 125               

tgc gtc tac atc cac ccc gac tcg ccc aac ttc ggg gcc cac tgg atg        435
Cys Val Tyr Ile His Pro Asp Ser Pro Asn Phe Gly Ala His Trp Met           
            130                 135                 140                   

aag gct ccc gtc tcc ttc agc aaa gtc aag ctc acc aac aag ctc aac        483
Lys Ala Pro Val Ser Phe Ser Lys Val Lys Leu Thr Asn Lys Leu Asn           
        145                 150                 155                       

gga ggg ggc cag atc atg ctg aac tcc ttg cat aag tat gag cct cga        531
Gly Gly Gly Gln Ile Met Leu Asn Ser Leu His Lys Tyr Glu Pro Arg           
    160                 165                 170                           

atc cac ata gtg aga gtt ggg gat cca cag cgc atg atc acc agc cac        579
Ile His Ile Val Arg Val Gly Asp Pro Gln Arg Met Ile Thr Ser His           
175                 180                 185                 190           

tgc ttc cct gag acc cag ttc ata gcg gtg act gct tat cag aac gag        627
Cys Phe Pro Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr Gln Asn Glu           
                195                 200                 205               

gag atc aca gct ctt aaa att aag tac aat cca ttt gca aaa gct ttc        675
Glu Ile Thr Ala Leu Lys Ile Lys Tyr Asn Pro Phe Ala Lys Ala Phe           
            210                 215                 220                   

ctt gat gca aag gaa aga agt gat cac aaa gag atg atg gag gaa ccc        723
Leu Asp Ala Lys Glu Arg Ser Asp His Lys Glu Met Met Glu Glu Pro           
        225                 230                 235                       

gga gac agc cag caa cct ggg tac tcc caa tgg ggg tgg ctt ctt cct        771
Gly Asp Ser Gln Gln Pro Gly Tyr Ser Gln Trp Gly Trp Leu Leu Pro           
    240                 245                 250                           

gga acc agc acc ctg tgt cca cct gca aat cct cat cct cag ttt gga        819
Gly Thr Ser Thr Leu Cys Pro Pro Ala Asn Pro His Pro Gln Phe Gly           
255                 260                 265                 270           

ggt gcc ctc tcc ctc ccc tcc acg cac agc tgt gac agg tac cca acc        867
Gly Ala Leu Ser Leu Pro Ser Thr His Ser Cys Asp Arg Tyr Pro Thr           
                275                 280                 285               

ctg agg agc cac cgg tcc tca ccc tac ccc agc ccc tat gct cat cgg        915
Leu Arg Ser His Arg Ser Ser Pro Tyr Pro Ser Pro Tyr Ala His Arg           
            290                 295                 300                   

aac aat tct cca acc tat tct gac aac tca cct gca tgt tta tcc atg        963
Asn Asn Ser Pro Thr Tyr Ser Asp Asn Ser Pro Ala Cys Leu Ser Met           
        305                 310                 315                       

ctg caa tcc cat gac aat tgg tcc agc ctt gga atg cct gcc cat ccc       1011
Leu Gln Ser His Asp Asn Trp Ser Ser Leu Gly Met Pro Ala His Pro           
    320                 325                 330                           

agc atg ctc ccc gtg agc cac aat gcc agc cca cct acc agc tcc agt       1059
Ser Met Leu Pro Val Ser His Asn Ala Ser Pro Pro Thr Ser Ser Ser           
335                 340                 345                 350           

cag tac ccc agc ctg tgg tct gtg agc aac ggc gcc gtc acc ccg ggc       1107
Gln Tyr Pro Ser Leu Trp Ser Val Ser Asn Gly Ala Val Thr Pro Gly           
                355                 360                 365               

tcc cag gca gca gcc gtg acc aac ggg ctg ggg gcc cag ttc ttc cgg       1155
Ser Gln Ala Ala Ala Val Thr Asn Gly Leu Gly Ala Gln Phe Phe Arg           
            370                 375                 380                   

ggc tcc ccc gcg cac tac aca ccc ctc acc cat ccg gtc tcg gca ccc       1203
Gly Ser Pro Ala His Tyr Thr Pro Leu Thr His Pro Val Ser Ala Pro           
        385                 390                 395                       

tct tcc tcg gga tcc cca ctg tac gaa ggg gcg gcc gcg gcc aca aac       1251
Ser Ser Ser Gly Ser Pro Leu Tyr Glu Gly Ala Ala Ala Ala Thr Asn           
    400                 405                 410                           

atc gtg gac agc cag tac gac gcc gca gcc caa ggc cgc ctc ata gcc       1299
Ile Val Asp Ser Gln Tyr Asp Ala Ala Ala Gln Gly Arg Leu Ile Ala           
415                 420                 425                 430           

tca tgg aca cct gtg tcg cca cct tcc atg cat cac cat cac cat cac       1347
Ser Trp Thr Pro Val Ser Pro Pro Ser Met His His His His His His           
                435                 440                 445               

tgagactagt                                                            1357


<210>  8
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  8

Met Ala Asp Glu Ala Pro Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Val Asp His Leu Leu Ser Ala Val Glu Asn Glu 
            20                  25                  30          


Leu Gln Ala Gly Ser Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg 
        35                  40                  45              


Val Gly Leu Glu Glu Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr 
    50                  55                  60                  


Asn Glu Met Ile Val Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu 
65                  70                  75                  80  


Lys Val Asn Val Ser Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu 
                85                  90                  95      


Leu Asp Phe Val Ala Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly 
            100                 105                 110         


Glu Trp Val Pro Gly Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val 
        115                 120                 125             


Tyr Ile His Pro Asp Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala 
    130                 135                 140                 


Pro Val Ser Phe Ser Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly 
145                 150                 155                 160 


Gly Gln Ile Met Leu Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His 
                165                 170                 175     


Ile Val Arg Val Gly Asp Pro Gln Arg Met Ile Thr Ser His Cys Phe 
            180                 185                 190         


Pro Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile 
        195                 200                 205             


Thr Ala Leu Lys Ile Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp 
    210                 215                 220                 


Ala Lys Glu Arg Ser Asp His Lys Glu Met Met Glu Glu Pro Gly Asp 
225                 230                 235                 240 


Ser Gln Gln Pro Gly Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr 
                245                 250                 255     


Ser Thr Leu Cys Pro Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala 
            260                 265                 270         


Leu Ser Leu Pro Ser Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg 
        275                 280                 285             


Ser His Arg Ser Ser Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn 
    290                 295                 300                 


Ser Pro Thr Tyr Ser Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln 
305                 310                 315                 320 


Ser His Asp Asn Trp Ser Ser Leu Gly Met Pro Ala His Pro Ser Met 
                325                 330                 335     


Leu Pro Val Ser His Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr 
            340                 345                 350         


Pro Ser Leu Trp Ser Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln 
        355                 360                 365             


Ala Ala Ala Val Thr Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser 
    370                 375                 380                 


Pro Ala His Tyr Thr Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser 
385                 390                 395                 400 


Ser Gly Ser Pro Leu Tyr Glu Gly Ala Ala Ala Ala Thr Asn Ile Val 
                405                 410                 415     


Asp Ser Gln Tyr Asp Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp 
            420                 425                 430         


Thr Pro Val Ser Pro Pro Ser Met His His His His His His 
        435                 440                 445     


<210>  9
<211>  1360
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (10)..(1353)

<400>  9
gaattccgc atg gcc gat gaa gct ccg agc tcg ccg ggc aca gag agc gca       51
          Met Ala Asp Glu Ala Pro Ser Ser Pro Gly Thr Glu Ser Ala         
          1               5                   10                          

ggg aag agc ctg cag tac cga gtg gac cac ctg ctc agc gcc gtg gag         99
Gly Lys Ser Leu Gln Tyr Arg Val Asp His Leu Leu Ser Ala Val Glu           
15                  20                  25                  30            

agc gag ctg cag gcg ggc agc gag aag gga gac ccc acc gaa cgc gaa        147
Ser Glu Leu Gln Ala Gly Ser Glu Lys Gly Asp Pro Thr Glu Arg Glu           
                35                  40                  45                

ctg cga gtg ggc ctg gag gag agc gag ctg tgg ctg cgc ttc aag gag        195
Leu Arg Val Gly Leu Glu Glu Ser Glu Leu Trp Leu Arg Phe Lys Glu           
            50                  55                  60                    

cta act aac gag atg att gtg acc aag aac ggc agg agg atg ttc ccg        243
Leu Thr Asn Glu Met Ile Val Thr Lys Asn Gly Arg Arg Met Phe Pro           
        65                  70                  75                        

gtg ctg aag gta aat gtg tca ggc ctg gac ccc aat gcc atg tac tct        291
Val Leu Lys Val Asn Val Ser Gly Leu Asp Pro Asn Ala Met Tyr Ser           
    80                  85                  90                            

ttc ttg ctg gac ttc gtg acg gct gac aac cac cgc tgg aaa tat gtg        339
Phe Leu Leu Asp Phe Val Thr Ala Asp Asn His Arg Trp Lys Tyr Val           
95                  100                 105                 110           

aac ggg gag tgg gta cct ggg ggc aaa cca gag cct cag gcg ccc agc        387
Asn Gly Glu Trp Val Pro Gly Gly Lys Pro Glu Pro Gln Ala Pro Ser           
                115                 120                 125               

tgc gtc tac atc cac cca gac tcg ccc aat ttt ggg gcc cac tgg atg        435
Cys Val Tyr Ile His Pro Asp Ser Pro Asn Phe Gly Ala His Trp Met           
            130                 135                 140                   

aag gcg cct gtg tct ttc agc aaa gtc aaa ctc acc aac aag ctc aat        483
Lys Ala Pro Val Ser Phe Ser Lys Val Lys Leu Thr Asn Lys Leu Asn           
        145                 150                 155                       

gga ggg gga cag atc atg tta aac tcc ttg cat aag tat gaa cct cgg        531
Gly Gly Gly Gln Ile Met Leu Asn Ser Leu His Lys Tyr Glu Pro Arg           
    160                 165                 170                           

att cac atc gtg aga gtt ggg ggc ccg caa cgc atg atc acc agc cac        579
Ile His Ile Val Arg Val Gly Gly Pro Gln Arg Met Ile Thr Ser His           
175                 180                 185                 190           

tgc ttt ccc gag acc cag ttc ata gct gtg act gcc tac cag aat gag        627
Cys Phe Pro Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr Gln Asn Glu           
                195                 200                 205               

gag att aca gcc ctt aaa att aaa tac aac cca ttt gct aaa gcc ttc        675
Glu Ile Thr Ala Leu Lys Ile Lys Tyr Asn Pro Phe Ala Lys Ala Phe           
            210                 215                 220                   

ctt gat gcc aaa gaa aga aac gac cac aaa gat gta atg gag gaa ccg        723
Leu Asp Ala Lys Glu Arg Asn Asp His Lys Asp Val Met Glu Glu Pro           
        225                 230                 235                       

ggg gac tgc cag cag ccg ggg tat tcc caa tgg ggg tgg ctt gtt cct        771
Gly Asp Cys Gln Gln Pro Gly Tyr Ser Gln Trp Gly Trp Leu Val Pro           
    240                 245                 250                           

ggt gct ggc acc ctc tgc ccg cct gcc agc tcc cac cct cag ttt gga        819
Gly Ala Gly Thr Leu Cys Pro Pro Ala Ser Ser His Pro Gln Phe Gly           
255                 260                 265                 270           

ggc tcg ctc tct ctc ccc tcc aca cac ggc tgt gag agg tac cca gct        867
Gly Ser Leu Ser Leu Pro Ser Thr His Gly Cys Glu Arg Tyr Pro Ala           
                275                 280                 285               

cta agg aac cac cgg tca tcg ccc tac ccc agc ccc tat gct cat cgg        915
Leu Arg Asn His Arg Ser Ser Pro Tyr Pro Ser Pro Tyr Ala His Arg           
            290                 295                 300                   

aac agc tct cca acc tac gcg gac aat tca tct gct tgt ctg tcc atg        963
Asn Ser Ser Pro Thr Tyr Ala Asp Asn Ser Ser Ala Cys Leu Ser Met           
        305                 310                 315                       

ctg cag tcc cat gat aac tgg tct agc ctc gga gtg cct ggc cac acc       1011
Leu Gln Ser His Asp Asn Trp Ser Ser Leu Gly Val Pro Gly His Thr           
    320                 325                 330                           

agc atg ctg cct gtg agt cat aac gcc agc cca cct act ggc tct agc       1059
Ser Met Leu Pro Val Ser His Asn Ala Ser Pro Pro Thr Gly Ser Ser           
335                 340                 345                 350           

cag tat ccc agt ctc tgg tct gtg agc aat ggt acc atc acc cca ggc       1107
Gln Tyr Pro Ser Leu Trp Ser Val Ser Asn Gly Thr Ile Thr Pro Gly           
                355                 360                 365               

tcc cag aca gct ggg gtg tcc aac ggg ctg gga gct cag ttc ttt cga       1155
Ser Gln Thr Ala Gly Val Ser Asn Gly Leu Gly Ala Gln Phe Phe Arg           
            370                 375                 380                   

ggc tcc cct gca cat tac aca cca ctg aca cac acg gtc tca gct gcc       1203
Gly Ser Pro Ala His Tyr Thr Pro Leu Thr His Thr Val Ser Ala Ala           
        385                 390                 395                       

acg tcc tcg tct tct ggt tct ccg atg tat gaa ggg gct gct aca gtc       1251
Thr Ser Ser Ser Ser Gly Ser Pro Met Tyr Glu Gly Ala Ala Thr Val           
    400                 405                 410                           

aca gac att tct gac agc cag tat gac acg gcc caa agc ctc ctc ata       1299
Thr Asp Ile Ser Asp Ser Gln Tyr Asp Thr Ala Gln Ser Leu Leu Ile           
415                 420                 425                 430           

gcc tcg tgg aca cct gtg tca ccc cca tct atg cat cac cat cac cat       1347
Ala Ser Trp Thr Pro Val Ser Pro Pro Ser Met His His His His His           
                435                 440                 445               

cac tga gactagt                                                       1360
His                                                                       
                                                                          


<210>  10
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  10

Met Ala Asp Glu Ala Pro Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Val Asp His Leu Leu Ser Ala Val Glu Ser Glu 
            20                  25                  30          


Leu Gln Ala Gly Ser Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg 
        35                  40                  45              


Val Gly Leu Glu Glu Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr 
    50                  55                  60                  


Asn Glu Met Ile Val Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu 
65                  70                  75                  80  


Lys Val Asn Val Ser Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu 
                85                  90                  95      


Leu Asp Phe Val Thr Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly 
            100                 105                 110         


Glu Trp Val Pro Gly Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val 
        115                 120                 125             


Tyr Ile His Pro Asp Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala 
    130                 135                 140                 


Pro Val Ser Phe Ser Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly 
145                 150                 155                 160 


Gly Gln Ile Met Leu Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His 
                165                 170                 175     


Ile Val Arg Val Gly Gly Pro Gln Arg Met Ile Thr Ser His Cys Phe 
            180                 185                 190         


Pro Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile 
        195                 200                 205             


Thr Ala Leu Lys Ile Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp 
    210                 215                 220                 


Ala Lys Glu Arg Asn Asp His Lys Asp Val Met Glu Glu Pro Gly Asp 
225                 230                 235                 240 


Cys Gln Gln Pro Gly Tyr Ser Gln Trp Gly Trp Leu Val Pro Gly Ala 
                245                 250                 255     


Gly Thr Leu Cys Pro Pro Ala Ser Ser His Pro Gln Phe Gly Gly Ser 
            260                 265                 270         


Leu Ser Leu Pro Ser Thr His Gly Cys Glu Arg Tyr Pro Ala Leu Arg 
        275                 280                 285             


Asn His Arg Ser Ser Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Ser 
    290                 295                 300                 


Ser Pro Thr Tyr Ala Asp Asn Ser Ser Ala Cys Leu Ser Met Leu Gln 
305                 310                 315                 320 


Ser His Asp Asn Trp Ser Ser Leu Gly Val Pro Gly His Thr Ser Met 
                325                 330                 335     


Leu Pro Val Ser His Asn Ala Ser Pro Pro Thr Gly Ser Ser Gln Tyr 
            340                 345                 350         


Pro Ser Leu Trp Ser Val Ser Asn Gly Thr Ile Thr Pro Gly Ser Gln 
        355                 360                 365             


Thr Ala Gly Val Ser Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser 
    370                 375                 380                 


Pro Ala His Tyr Thr Pro Leu Thr His Thr Val Ser Ala Ala Thr Ser 
385                 390                 395                 400 


Ser Ser Ser Gly Ser Pro Met Tyr Glu Gly Ala Ala Thr Val Thr Asp 
                405                 410                 415     


Ile Ser Asp Ser Gln Tyr Asp Thr Ala Gln Ser Leu Leu Ile Ala Ser 
            420                 425                 430         


Trp Thr Pro Val Ser Pro Pro Ser Met His His His His His His 
        435                 440                 445         


<210>  11
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  11

Met Ala Asp Glu Ala Pro 
1               5       


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Trp Leu Leu Pro Gly Thr Ser Thr Leu 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Trp Leu Leu Pro Gly Thr Ser Thr Val 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Gln Tyr Pro Ser Leu Trp Ser Val 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Leu Ile Ala Ser Trp Thr Pro Val 
1               5                   


<210>  16
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Met Tyr Ser Phe Leu Leu Asp Phe Val 
1               5                   10  


<210>  17
<211>  1305
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (1)..(1305)

<400>  17
atg agc tcc cct ggc acc gag agc gcg gga aag agc ctg cag tac cga         48
Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser Leu Gln Tyr Arg           
1               5                   10                  15                

gtg gac cac ctg ctg agc gcc gtg gag aat gag ctg cag gcg ggc agc         96
Val Asp His Leu Leu Ser Ala Val Glu Asn Glu Leu Gln Ala Gly Ser           
            20                  25                  30                    

gag aag ggc gac ccc aca gag cgc gaa ctg cgc gtg ggc ctg gag gag        144
Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg Val Gly Leu Glu Glu           
        35                  40                  45                        

agc gag ctg tgg ctg cgc ttc aag gag ctc acc aat gag atg atc gtg        192
Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn Glu Met Ile Val           
    50                  55                  60                            

acc aag aac ggc agg agg atg ttt ccg gtg ctg aag gtg aac gtg tct        240
Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys Val Asn Val Ser           
65                  70                  75                  80            

ggc ctg gac ccc aac gcc atg tac tcc ttc ctg ctg gac ttc gtg gcg        288
Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu Asp Phe Val Ala           
                85                  90                  95                

gcg gac aac cac cgc tgg aag tac gtg aac ggg gaa tgg gtg ccg ggg        336
Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu Trp Val Pro Gly           
            100                 105                 110                   

ggc aag ccg gag ccg cag gcg ccc agc tgc gtc tac atc cac ccc gac        384
Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val Tyr Ile His Pro Asp           
        115                 120                 125                       

tcg ccc aac ttc ggg gcc cac tgg atg aag gct ccc gtc tcc ttc agc        432
Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro Val Ser Phe Ser           
    130                 135                 140                           

aaa gtc aag ctc acc aac aag ctc aac gga ggg ggc cag atc atg ctg        480
Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly Gln Ile Met Leu           
145                 150                 155                 160           

aac tcc ttg cat aag tat gag cct cga atc cac ata gtg aga gtt ggg        528
Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile Val Arg Val Gly           
                165                 170                 175               

gat cca cag cgc atg atc acc agc cac tgc ttc cct gag acc cag ttc        576
Asp Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro Glu Thr Gln Phe           
            180                 185                 190                   

ata gcg gtg act gct tat cag aac gag gag atc aca gct ctt aaa att        624
Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr Ala Leu Lys Ile           
        195                 200                 205                       

aag tac aat cca ttt gca aaa gct ttc ctt gat gca aag gaa aga agt        672
Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala Lys Glu Arg Ser           
    210                 215                 220                           

gat cac aaa gag atg atg gag gaa ccc gga gac agc cag caa cct ggg        720
Asp His Lys Glu Met Met Glu Glu Pro Gly Asp Ser Gln Gln Pro Gly           
225                 230                 235                 240           

tac tcc caa tgg ggg tgg ctt ctt cct gga acc agc acc gtg tgt cca        768
Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr Ser Thr Val Cys Pro           
                245                 250                 255               

cct gca aat cct cat cct cag ttt gga ggt gcc ctc tcc ctc ccc tcc        816
Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala Leu Ser Leu Pro Ser           
            260                 265                 270                   

acg cac agc tgt gac agg tac cca acc ctg agg agc cac cgg tcc tca        864
Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg Ser His Arg Ser Ser           
        275                 280                 285                       

ccc tac ccc agc ccc tat gct cat cgg aac aat tct cca acc tat tct        912
Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn Ser Pro Thr Tyr Ser           
    290                 295                 300                           

gac aac tca cct gca tgt tta tcc atg ctg caa tcc cat gac aat tgg        960
Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln Ser His Asp Asn Trp           
305                 310                 315                 320           

tcc agc ctt gga atg cct gcc cat ccc agc atg ctc ccc gtg agc cac       1008
Ser Ser Leu Gly Met Pro Ala His Pro Ser Met Leu Pro Val Ser His           
                325                 330                 335               

aat gcc agc cca cct acc agc tcc agt cag tac ccc agc ctg tgg tct       1056
Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr Pro Ser Leu Trp Ser           
            340                 345                 350                   

gtg agc aac ggc gcc gtc acc ccg ggc tcc cag gca gca gcc gtg acc       1104
Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln Ala Ala Ala Val Thr           
        355                 360                 365                       

aac ggg ctg ggg gcc cag ttc ttc cgg ggc tcc ccc gcg cac tac aca       1152
Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro Ala His Tyr Thr           
    370                 375                 380                           

ccc ctc acc cat ccg gtc tcg gca ccc tct tcc tcg gga tcc cca ctg       1200
Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser Ser Gly Ser Pro Leu           
385                 390                 395                 400           

tac gaa ggg gcg gcc gcg gcc aca aac atc gtg gac agc cag tac gac       1248
Tyr Glu Gly Ala Ala Ala Ala Thr Asn Ile Val Asp Ser Gln Tyr Asp           
                405                 410                 415               

gcc gca gcc caa ggc cgc ctc ata gcc tca tgg aca cct gtg tcg cca       1296
Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp Thr Pro Val Ser Pro           
            420                 425                 430                   

cct tcc atg                                                           1305
Pro Ser Met                                                               
        435                                                               


<210>  18
<211>  435
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  18

Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser Leu Gln Tyr Arg 
1               5                   10                  15      


Val Asp His Leu Leu Ser Ala Val Glu Asn Glu Leu Gln Ala Gly Ser 
            20                  25                  30          


Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg Val Gly Leu Glu Glu 
        35                  40                  45              


Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn Glu Met Ile Val 
    50                  55                  60                  


Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys Val Asn Val Ser 
65                  70                  75                  80  


Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu Asp Phe Val Ala 
                85                  90                  95      


Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu Trp Val Pro Gly 
            100                 105                 110         


Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val Tyr Ile His Pro Asp 
        115                 120                 125             


Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro Val Ser Phe Ser 
    130                 135                 140                 


Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly Gln Ile Met Leu 
145                 150                 155                 160 


Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile Val Arg Val Gly 
                165                 170                 175     


Asp Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro Glu Thr Gln Phe 
            180                 185                 190         


Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr Ala Leu Lys Ile 
        195                 200                 205             


Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala Lys Glu Arg Ser 
    210                 215                 220                 


Asp His Lys Glu Met Met Glu Glu Pro Gly Asp Ser Gln Gln Pro Gly 
225                 230                 235                 240 


Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr Ser Thr Val Cys Pro 
                245                 250                 255     


Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala Leu Ser Leu Pro Ser 
            260                 265                 270         


Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg Ser His Arg Ser Ser 
        275                 280                 285             


Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn Ser Pro Thr Tyr Ser 
    290                 295                 300                 


Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln Ser His Asp Asn Trp 
305                 310                 315                 320 


Ser Ser Leu Gly Met Pro Ala His Pro Ser Met Leu Pro Val Ser His 
                325                 330                 335     


Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr Pro Ser Leu Trp Ser 
            340                 345                 350         


Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln Ala Ala Ala Val Thr 
        355                 360                 365             


Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro Ala His Tyr Thr 
    370                 375                 380                 


Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser Ser Gly Ser Pro Leu 
385                 390                 395                 400 


Tyr Glu Gly Ala Ala Ala Ala Thr Asn Ile Val Asp Ser Gln Tyr Asp 
                405                 410                 415     


Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp Thr Pro Val Ser Pro 
            420                 425                 430         


Pro Ser Met 
        435 


<210>  19
<211>  1370
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (10)..(1350)

<400>  19
gaattccgc atg gcc gat gaa gct ccg agc tcc cct ggc acc gag agc gcg       51
          Met Ala Asp Glu Ala Pro Ser Ser Pro Gly Thr Glu Ser Ala         
          1               5                   10                          

gga aag agc ctg cag tac cga gtg gac cac ctg ctg agc gcc gtg gag         99
Gly Lys Ser Leu Gln Tyr Arg Val Asp His Leu Leu Ser Ala Val Glu           
15                  20                  25                  30            

aat gag ctg cag gcg ggc agc gag aag ggc gac ccc aca gag cgc gaa        147
Asn Glu Leu Gln Ala Gly Ser Glu Lys Gly Asp Pro Thr Glu Arg Glu           
                35                  40                  45                

ctg cgc gtg ggc ctg gag gag agc gag ctg tgg ctg cgc ttc aag gag        195
Leu Arg Val Gly Leu Glu Glu Ser Glu Leu Trp Leu Arg Phe Lys Glu           
            50                  55                  60                    

ctc acc aat gag atg atc gtg acc aag aac ggc agg agg atg ttt ccg        243
Leu Thr Asn Glu Met Ile Val Thr Lys Asn Gly Arg Arg Met Phe Pro           
        65                  70                  75                        

gtg ctg aag gtg aac gtg tct ggc ctg gac ccc aac gcc atg tac tcc        291
Val Leu Lys Val Asn Val Ser Gly Leu Asp Pro Asn Ala Met Tyr Ser           
    80                  85                  90                            

ttc ctg ctg gac ttc gtg gcg gcg gac aac cac cgc tgg aag tac gtg        339
Phe Leu Leu Asp Phe Val Ala Ala Asp Asn His Arg Trp Lys Tyr Val           
95                  100                 105                 110           

aac ggg gaa tgg gtg ccg ggg ggc aag ccg gag ccg cag gcg ccc agc        387
Asn Gly Glu Trp Val Pro Gly Gly Lys Pro Glu Pro Gln Ala Pro Ser           
                115                 120                 125               

tgc gtc tac atc cac ccc gac tcg ccc aac ttc ggg gcc cac tgg atg        435
Cys Val Tyr Ile His Pro Asp Ser Pro Asn Phe Gly Ala His Trp Met           
            130                 135                 140                   

aag gct ccc gtc tcc ttc agc aaa gtc aag ctc acc aac aag ctc aac        483
Lys Ala Pro Val Ser Phe Ser Lys Val Lys Leu Thr Asn Lys Leu Asn           
        145                 150                 155                       

gga ggg ggc cag atc atg ctg aac tcc ttg cat aag tat gag cct cga        531
Gly Gly Gly Gln Ile Met Leu Asn Ser Leu His Lys Tyr Glu Pro Arg           
    160                 165                 170                           

atc cac ata gtg aga gtt ggg gat cca cag cgc atg atc acc agc cac        579
Ile His Ile Val Arg Val Gly Asp Pro Gln Arg Met Ile Thr Ser His           
175                 180                 185                 190           

tgc ttc cct gag acc cag ttc ata gcg gtg act gct tat cag aac gag        627
Cys Phe Pro Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr Gln Asn Glu           
                195                 200                 205               

gag atc aca gct ctt aaa att aag tac aat cca ttt gca aaa gct ttc        675
Glu Ile Thr Ala Leu Lys Ile Lys Tyr Asn Pro Phe Ala Lys Ala Phe           
            210                 215                 220                   

ctt gat gca aag gaa aga agt gat cac aaa gag atg atg gag gaa ccc        723
Leu Asp Ala Lys Glu Arg Ser Asp His Lys Glu Met Met Glu Glu Pro           
        225                 230                 235                       

gga gac agc cag caa cct ggg tac tcc caa tgg ggg tgg ctt ctt cct        771
Gly Asp Ser Gln Gln Pro Gly Tyr Ser Gln Trp Gly Trp Leu Leu Pro           
    240                 245                 250                           

gga acc agc acc gtg tgt cca cct gca aat cct cat cct cag ttt gga        819
Gly Thr Ser Thr Val Cys Pro Pro Ala Asn Pro His Pro Gln Phe Gly           
255                 260                 265                 270           

ggt gcc ctc tcc ctc ccc tcc acg cac agc tgt gac agg tac cca acc        867
Gly Ala Leu Ser Leu Pro Ser Thr His Ser Cys Asp Arg Tyr Pro Thr           
                275                 280                 285               

ctg agg agc cac cgg tcc tca ccc tac ccc agc ccc tat gct cat cgg        915
Leu Arg Ser His Arg Ser Ser Pro Tyr Pro Ser Pro Tyr Ala His Arg           
            290                 295                 300                   

aac aat tct cca acc tat tct gac aac tca cct gca tgt tta tcc atg        963
Asn Asn Ser Pro Thr Tyr Ser Asp Asn Ser Pro Ala Cys Leu Ser Met           
        305                 310                 315                       

ctg caa tcc cat gac aat tgg tcc agc ctt gga atg cct gcc cat ccc       1011
Leu Gln Ser His Asp Asn Trp Ser Ser Leu Gly Met Pro Ala His Pro           
    320                 325                 330                           

agc atg ctc ccc gtg agc cac aat gcc agc cca cct acc agc tcc agt       1059
Ser Met Leu Pro Val Ser His Asn Ala Ser Pro Pro Thr Ser Ser Ser           
335                 340                 345                 350           

cag tac ccc agc ctg tgg tct gtg agc aac ggc gcc gtc acc ccg ggc       1107
Gln Tyr Pro Ser Leu Trp Ser Val Ser Asn Gly Ala Val Thr Pro Gly           
                355                 360                 365               

tcc cag gca gca gcc gtg acc aac ggg ctg ggg gcc cag ttc ttc cgg       1155
Ser Gln Ala Ala Ala Val Thr Asn Gly Leu Gly Ala Gln Phe Phe Arg           
            370                 375                 380                   

ggc tcc ccc gcg cac tac aca ccc ctc acc cat ccg gtc tcg gca ccc       1203
Gly Ser Pro Ala His Tyr Thr Pro Leu Thr His Pro Val Ser Ala Pro           
        385                 390                 395                       

tct tcc tcg gga tcc cca ctg tac gaa ggg gcg gcc gcg gcc aca aac       1251
Ser Ser Ser Gly Ser Pro Leu Tyr Glu Gly Ala Ala Ala Ala Thr Asn           
    400                 405                 410                           

atc gtg gac agc cag tac gac gcc gca gcc caa ggc cgc ctc ata gcc       1299
Ile Val Asp Ser Gln Tyr Asp Ala Ala Ala Gln Gly Arg Leu Ile Ala           
415                 420                 425                 430           

tca tgg aca cct gtg tcg cca cct tcc atg cat cac cat cac cat cac       1347
Ser Trp Thr Pro Val Ser Pro Pro Ser Met His His His His His His           
                435                 440                 445               

tga gactagtccc gggcggccgc                                             1370


<210>  20
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  20

Met Ala Asp Glu Ala Pro Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Val Asp His Leu Leu Ser Ala Val Glu Asn Glu 
            20                  25                  30          


Leu Gln Ala Gly Ser Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg 
        35                  40                  45              


Val Gly Leu Glu Glu Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr 
    50                  55                  60                  


Asn Glu Met Ile Val Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu 
65                  70                  75                  80  


Lys Val Asn Val Ser Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu 
                85                  90                  95      


Leu Asp Phe Val Ala Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly 
            100                 105                 110         


Glu Trp Val Pro Gly Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val 
        115                 120                 125             


Tyr Ile His Pro Asp Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala 
    130                 135                 140                 


Pro Val Ser Phe Ser Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly 
145                 150                 155                 160 


Gly Gln Ile Met Leu Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His 
                165                 170                 175     


Ile Val Arg Val Gly Asp Pro Gln Arg Met Ile Thr Ser His Cys Phe 
            180                 185                 190         


Pro Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile 
        195                 200                 205             


Thr Ala Leu Lys Ile Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp 
    210                 215                 220                 


Ala Lys Glu Arg Ser Asp His Lys Glu Met Met Glu Glu Pro Gly Asp 
225                 230                 235                 240 


Ser Gln Gln Pro Gly Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr 
                245                 250                 255     


Ser Thr Val Cys Pro Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala 
            260                 265                 270         


Leu Ser Leu Pro Ser Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg 
        275                 280                 285             


Ser His Arg Ser Ser Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn 
    290                 295                 300                 


Ser Pro Thr Tyr Ser Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln 
305                 310                 315                 320 


Ser His Asp Asn Trp Ser Ser Leu Gly Met Pro Ala His Pro Ser Met 
                325                 330                 335     


Leu Pro Val Ser His Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr 
            340                 345                 350         


Pro Ser Leu Trp Ser Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln 
        355                 360                 365             


Ala Ala Ala Val Thr Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser 
    370                 375                 380                 


Pro Ala His Tyr Thr Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser 
385                 390                 395                 400 


Ser Gly Ser Pro Leu Tyr Glu Gly Ala Ala Ala Ala Thr Asn Ile Val 
                405                 410                 415     


Asp Ser Gln Tyr Asp Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp 
            420                 425                 430         


Thr Pro Val Ser Pro Pro Ser Met His His His His His His 
        435                 440                 445     


