                         SEQUENCE LISTING

<110>  Exerkine Corporation
 
<120>  THERAPEUTIC METHOD OF TREATING METABOLIC SYNDROME

<130>  H8312935PCT

<140>  PCT/CA2014/000439
<141>  2014-05-16

<150>  US 61/824702
<151>  2013-05-17

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Gly Ala Ala Arg Ala Ala Trp Gly Arg Ala Gly Gln Pro Trp 
1               5                   10                  15      


Pro Arg Pro Pro Ala Pro Gly Pro Pro Pro Pro Pro Leu Pro Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Ala Gly Leu Leu Gly Gly Ala Gly Ala Gln Tyr Ser 
        35                  40                  45              


Ser Asp Arg Cys Ser Trp Lys Gly Ser Gly Leu Thr His Glu Ala His 
    50                  55                  60                  


Arg Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ala Ala Gly Ala Val 
65                  70                  75                  80  


Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Leu Arg Pro Asn 
                85                  90                  95      


Thr Phe Ser Pro Ala Arg His Leu Thr Val Cys Ile Arg Ser Phe Thr 
            100                 105                 110         


Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu Arg 
        115                 120                 125             


Leu Leu Val Pro Asp Gly Asp Gly Arg Pro Gly Arg Val Gln Cys Phe 
    130                 135                 140                 


Gly Leu Glu Gln Gly Gly Leu Phe Val Glu Ala Thr Pro Gln Gln Asp 
145                 150                 155                 160 


Ile Gly Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Val Arg Arg His 
                165                 170                 175     


Arg Ala Ser Asp Leu His Glu Leu Ser Ala Pro Cys Arg Pro Cys Ser 
            180                 185                 190         


Asp Thr Glu Val Leu Leu Ala Val Cys Thr Ser Asp Phe Ala Val Arg 
        195                 200                 205             


Gly Ser Ile Gln Gln Val Thr His Glu Pro Glu Arg Gln Asp Ser Ala 
    210                 215                 220                 


Ile His Leu Arg Val Ser Arg Leu Tyr Arg Gln Lys Ser Arg Val Phe 
225                 230                 235                 240 


Glu Pro Val Pro Glu Gly Asp Gly His Trp Gln Gly Arg Val Arg Thr 
                245                 250                 255     


Leu Leu Glu Cys Gly Val Arg Pro Gly His Gly Asp Phe Leu Phe Thr 
            260                 265                 270         


Gly His Met His Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg Phe 
        275                 280                 285             


Lys Asp Phe Gln Arg Met Tyr Arg Asp Ala Gln Glu Arg Gly Leu Asn 
    290                 295                 300                 


Pro Cys Glu Val Gly Thr Asp 
305                 310     


<210>  2
<211>  311
<212>  PRT
<213>  Rattus rattus

<400>  2

Met Arg Gly Val Val Trp Ala Ala Arg Arg Arg Ala Gly Gln Gln Trp 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Gly Pro Gly Pro Pro Pro Pro Pro Pro Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Leu Gly Gly Ala Ser Ala Gln Tyr Ser 
        35                  40                  45              


Ser Asp Leu Cys Ser Trp Lys Gly Ser Gly Leu Thr Arg Glu Ala His 
    50                  55                  60                  


Ser Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ser Ala Gly Ser Val 
65                  70                  75                  80  


Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Leu Arg Pro Asn 
                85                  90                  95      


Thr Phe Ser Pro Ala Gln Asn Leu Thr Val Cys Ile Lys Pro Phe Arg 
            100                 105                 110         


Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu Arg 
        115                 120                 125             


Leu Leu Val Arg Asp Val Arg Gly Glu Pro Gly Gln Val Gln Cys Phe 
    130                 135                 140                 


Ser Leu Glu Gln Gly Gly Leu Phe Val Glu Ala Thr Pro Gln Gln Asp 
145                 150                 155                 160 


Ile Ser Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Met Ser Gly Gln 
                165                 170                 175     


Arg Gly Leu Asp Leu His Val Leu Ser Ala Pro Cys Arg Pro Cys Ser 
            180                 185                 190         


Asp Thr Glu Val Leu Leu Ala Ile Cys Thr Ser Asp Phe Val Val Arg 
        195                 200                 205             


Gly Phe Ile Glu Asp Val Thr His Val Pro Glu Gln Gln Val Ser Val 
    210                 215                 220                 


Ile His Leu Arg Val Ser Arg Leu His Arg Gln Lys Ser Arg Val Phe 
225                 230                 235                 240 


Gln Pro Ala Pro Glu Asp Ser Gly His Trp Leu Gly His Val Thr Thr 
                245                 250                 255     


Leu Leu Gln Cys Gly Val Arg Pro Gly His Gly Glu Phe Leu Phe Thr 
            260                 265                 270         


Gly His Val His Phe Gly Glu Ala Gln Leu Gly Cys Ala Pro Arg Phe 
        275                 280                 285             


Ser Asp Phe Gln Lys Met Tyr Arg Lys Ala Glu Glu Arg Gly Ile Asn 
    290                 295                 300                 


Pro Cys Glu Ile Asn Met Glu 
305                 310     


<210>  3
<211>  311
<212>  PRT
<213>  Mus musculus

<400>  3

Met Arg Gly Ala Val Trp Ala Ala Arg Arg Arg Ala Gly Gln Gln Trp 
1               5                   10                  15      


Pro Arg Ser Pro Gly Pro Gly Pro Gly Pro Pro Pro Pro Pro Pro Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Leu Gly Gly Ala Ser Ala Gln Tyr Ser 
        35                  40                  45              


Ser Asp Leu Cys Ser Trp Lys Gly Ser Gly Leu Thr Arg Glu Ala Arg 
    50                  55                  60                  


Ser Lys Glu Val Glu Gln Val Tyr Leu Arg Cys Ser Ala Gly Ser Val 
65                  70                  75                  80  


Glu Trp Met Tyr Pro Thr Gly Ala Leu Ile Val Asn Leu Arg Pro Asn 
                85                  90                  95      


Thr Phe Ser Pro Ala Gln Asn Leu Thr Val Cys Ile Lys Pro Phe Arg 
            100                 105                 110         


Asp Ser Ser Gly Ala Asn Ile Tyr Leu Glu Lys Thr Gly Glu Leu Arg 
        115                 120                 125             


Leu Leu Val Arg Asp Ile Arg Gly Glu Pro Gly Gln Val Gln Cys Phe 
    130                 135                 140                 


Ser Leu Glu Gln Gly Gly Leu Phe Val Glu Ala Thr Pro Gln Gln Asp 
145                 150                 155                 160 


Ile Ser Arg Arg Thr Thr Gly Phe Gln Tyr Glu Leu Met Ser Gly Gln 
                165                 170                 175     


Arg Gly Leu Asp Leu His Val Leu Ser Ala Pro Cys Arg Pro Cys Ser 
            180                 185                 190         


Asp Thr Glu Val Leu Leu Ala Ile Cys Thr Ser Asp Phe Val Val Arg 
        195                 200                 205             


Gly Phe Ile Glu Asp Val Thr His Val Pro Glu Gln Gln Val Ser Val 
    210                 215                 220                 


Ile Tyr Leu Arg Val Asn Arg Leu His Arg Gln Lys Ser Arg Val Phe 
225                 230                 235                 240 


Gln Pro Ala Pro Glu Asp Ser Gly His Trp Leu Gly His Val Thr Thr 
                245                 250                 255     


Leu Leu Gln Cys Gly Val Arg Pro Gly His Gly Glu Phe Leu Phe Thr 
            260                 265                 270         


Gly His Val His Phe Gly Glu Ala Gln Leu Gly Cys Ala Pro Arg Phe 
        275                 280                 285             


Ser Asp Phe Gln Arg Met Tyr Arg Lys Ala Glu Glu Met Gly Ile Asn 
    290                 295                 300                 


Pro Cys Glu Ile Asn Met Glu 
305                 310     


<210>  4
<211>  1348
<212>  DNA
<213>  Homo sapiens

<400>  4
gcggggggcg cgcgacgtga ccacccggac tcgaagcccg ccccgccccc gcccggctcg       60

ccggctccgg ggtctgctcc gggggtcgcg gacgcggggc cgggcggcgg agccggcgcc      120

agagcatgcg gggcgcggcg cgggcggcct gggggcgcgc ggggcagccg tggccgcgac      180

cccccgcccc gggcccgccc ccgccgccgc tcccgctgct gctcctgctc ctggccgggc      240

tgctgggcgg cgcgggcgcg cagtactcca gcgaccggtg cagctggaag gggagcgggc      300

tgacgcacga ggcacacagg aaggaggtgg agcaggtgta tctgcgctgt gcggcgggtg      360

ccgtggagtg gatgtaccca acaggtgctc tcatcgttaa cctgcggccc aacaccttct      420

cgcctgcccg gcacctgacc gtgtgcatca ggtccttcac ggactcctcg ggggccaata      480

tttatttgga aaaaactgga gaactgagac tgctggtacc ggacggggac ggcaggcccg      540

gccgggtgca gtgttttggc ctggagcagg gcggcctgtt cgtggaggcc acgccgcagc      600

aggatatcgg ccggaggacc acaggcttcc agtacgagct ggttaggagg cacagggcgt      660

cggacctgca cgagctgtct gcgccgtgcc gtccctgcag tgacaccgag gtgctcctag      720

ccgtctgcac cagcgacttc gccgttcgag gctccatcca gcaagttacc cacgagcctg      780

agcggcagga ctcagccatc cacctgcgcg tgagcagact ctatcggcag aaaagcaggg      840

tcttcgagcc ggtgcccgag ggtgacggcc actggcaggg gcgcgtcagg acgctgctgg      900

agtgtggcgt gcggccgggg catggcgact tcctcttcac tggccacatg cacttcgggg      960

aggcgcggct cggctgtgcc ccacgcttca aggacttcca gaggatgtac agggatgccc     1020

aggagagggg gctgaaccct tgtgaggttg gcacggactg actccgtggg ccgctgccct     1080

tcctctcctg atgagtcaca ggctgcggtg ggcgctgcgg tcctggtggg gccgtgcggt     1140

gagggccgcg cgctgggagc cgcatgccct gggcccaggc ctgaccctgg taccgaagct     1200

gtggacgttc tcgccacact caaccccatg agcttccagc caaggatgcc ctggccgatt     1260

ggaaatgctg taaaatgcaa actaagttat tatatttttt tttggtaaaa aagaaatgtc     1320

cataggaaac aaaaaaaaaa aaaaaaaa                                        1348


<210>  5
<211>  1380
<212>  DNA
<213>  Rattus rattus

<400>  5
ggcagccggc gcgcttctct ggttgcagct tgggcggctg gggcggctcc tatggtgggc       60

ggccaggggc tagacgggat ggcctgtaga cgcgcgacgt gatcagctcg cacgcggacc      120

cacgcctccc gcagcactgc ctcaacagtc tattctgtgg gtgcaggcac gcaccggtct      180

cagaccctgc cggagcatgc ggggtgtggt gtgggcggcc cggaggcgcg cggggcagca      240

gtggcctcgg tccccgggcc ctgggccggg tccgcccccg ccgccaccgc tgctgttgct      300

gctactgctg ctgctgggcg gcgcgagcgc gcagtactcc agcgacctgt gcagctggaa      360

ggggagtggg ctcacccggg aggcacacag caaggaggtg gagcaggtgt acctgcgctg      420

ctcagcaggc tctgtggaat ggatgtaccc aaccggggcg ctcattgtta acctacggcc      480

caacaccttc tcacctgccc agaacttgac tgtgtgcatc aagcctttca gggactcctc      540

tggggccaat atttatttgg aaaaaactgg agaactaaga ctgttggtgc gggatgtcag      600

aggcgaacct ggccaagtgc agtgcttcag cctagagcag ggaggcttat ttgtggaggc      660

cacaccccag caggacatca gcagaaggac cacaggcttc cagtatgagc tgatgagtgg      720

gcagagggga ctggacctgc acgtgctctc tgccccctgt cgaccttgca gcgacactga      780

ggtcctcctt gccatctgca ccagtgactt tgttgtccga ggcttcatcg aggatgtcac      840

ccatgtacca gaacagcaag tgtcagtcat tcacctacgg gtgagcaggc tccacaggca      900

gaagagcagg gtcttccagc cagctcctga ggacagtggc cactggctgg gccatgtcac      960

aacactgttg cagtgtggag tacgaccagg gcatggagaa ttcctcttca ctggacatgt     1020

gcactttggg gaggcacaac ttggatgtgc cccacgcttt agtgactttc aaaagatgta     1080

caggaaagca gaagaaaggg gcataaaccc ttgtgaaata aatatggagt gacttgcagg     1140

gtgacaccgt actgctgtcc ttcagatgag ccatggctca gttgctctat caaatcccga     1200

tagagattgc agactggtgg catgagcccc gcctggtgct tgaactggga agggaggtac     1260

atgctgctct gaccccttag gtcccattca aggatgccct gacccattgg aaatgttgta     1320

aaatgcaaac taagttatta tatttttttt gtaaaagaaa aaaaaaaaaa aaaaaaaaaa     1380


<210>  6
<211>  2468
<212>  DNA
<213>  Mus musculus

<400>  6
agaggttcta ggggcagccg gcgcgcttct ctagttgcag cttgggcggc tcctgtggtg       60

ggcggctagg ggcgagccgg gatgggctat agacgcgcga cgtgatcagt tcgcacgcgg      120

acccacgcct cccatcgctc tgcctcaaga gcctattctg tgggtgcagg cacgcaccgg      180

acgcagaccc ggccggagca tgcggggtgc ggtgtgggcg gcccggaggc gcgcggggca      240

gcagtggcct cggtccccgg gccctgggcc gggtccgccc ccgccgccac cgctgctgtt      300

gctgctacta ctgctgctgg gcggcgcgag cgctcagtac tccagcgacc tgtgcagctg      360

gaaggggagt gggctcaccc gagaggcacg cagcaaggag gtggagcagg tgtacctgcg      420

ctgctccgca ggctctgtgg agtggatgta cccaactggg gcgctcattg ttaacctacg      480

gcccaacacc ttctcacctg cccagaactt gactgtgtgc atcaagcctt tcagggactc      540

ctctggagcc aatatttatt tggaaaaaac tggagaacta agactgttgg tgcgggacat      600

cagaggtgag cctggccaag tgcagtgctt cagcctggag cagggaggct tatttgtgga      660

ggcgacaccc caacaggaca tcagcagaag gaccacaggc ttccagtatg agctgatgag      720

tgggcagagg ggactggacc tgcacgtgct gtctgccccc tgtcggcctt gcagtgacac      780

tgaggtcctc cttgccatct gtaccagtga ctttgttgtc cgaggcttca ttgaggacgt      840

cacacatgta ccagaacagc aagtgtcagt catctacctg cgggtgaaca ggcttcacag      900

gcagaagagc agggtcttcc agccagctcc tgaggacagt ggccactggc tgggccatgt      960

cacaacactg ctgcagtgtg gagtacgacc agggcatggg gaattcctct tcactggaca     1020

tgtgcacttt ggggaggcac aacttggatg tgccccacgc tttagtgact ttcaaaggat     1080

gtacaggaaa gcagaagaaa tgggcataaa cccctgtgaa atcaatatgg agtgacttgc     1140

agggtgacac agtactgttg tccttcagat gagccatgtt ttgtgggctc agtcgctcta     1200

tcatatcctg atagagattg cagactggtg gcatgggccc agcctggtgc tagaactggg     1260

aaggtacatg ctgctctgac cccttaggtc ccagccaagg atgccctgac ccattggaac     1320

tgctgtaaaa tgcaaactaa gttattatat tttttttgta aaagatgcct tggtgtgcca     1380

tttaatagtg tttttacaaa gttattttca ggcattggat ttggcctggt atattggtgg     1440

gagctaggtt atggtgtgca gtgatggcta tggctcagcc ttgttattcc tgtgatggaa     1500

atgtatggag caaatacttt ctaatttccc cttcatttta ttttctattt taaaagacca     1560

tctttgccgt tgagaacctt tccagactgt atggaggctg ctcccattcc agggagtaaa     1620

gaccaggatc tgagactagt attacatcca tcttaaccca tcagatgggt acctgcattg     1680

aaccttctct gctcagctat ggcctgctgt cccaaagacc ttttgctctc tggacagttc     1740

cagatggtgc tgcctggctt aagggacttg ttcctccctt gctcctacca ggccactgtt     1800

gctttctgca tctgtcccac tgaaccagtc ttgtcctttg accctgagtt tccccaaatg     1860

cacacatcaa atccctgaat accaagggac taacctactt aatggcccat ttcttcagag     1920

ggtgtgggtt ttccctatag taagaaaatc tccacaagtt gaagcttaaa cagtaggctt     1980

tcgttcatac agtcctggaa gccagaatgg gtgtgagcag aatcacattt cctccggaga     2040

ctccaggagg gactttatag cttctggtga ctccaggaat ccttggcttg taacaatttc     2100

actctggcat tgctttccct gccatgtgac ttctgccttg tatgtgaggg cctgtatcaa     2160

atctctgtct tgggaggata cagatcattg acttagggcc cactccggtg acctcacctt     2220

cacctgaaat ttactcgatt tccatttagg tcagaggcaa aggctacaaa aaatatcaaa     2280

tccggagaaa gattcaatgg ttaggcactt gctactctta caaaggacct gtgttcgatt     2340

cccatgttgg gaactcatgt taggtggctt aaaattgcct ataactacaa ttccagggga     2400

tctagcaacc tcttctcgcc acacacaagc acacacacac acacacacac acacacacaa     2460

ttaaaaac                                                              2468


