                               SEQUENCE LISTING

<110> THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF
      MILITARY MEDICINE 
 
<120> DESIGN AND USE OF SPECIFIC REGULATORY T-CELLS TO INDUCE IMMUNE 
      TOLERANCE

<130> 103783-0175

<140> PCT/US2014/037524
<141> 2014-05-09

<150> 61/821,857
<151> 2013-05-10

<160> 10     

<170> PatentIn version 3.5

<210> 1
<211> 602
<212> PRT
<213> Homo sapiens

<400> 1
Arg Gln Val Ala Arg Val Ile Val Phe Leu Thr Leu Ser Thr Leu Ser 
1               5                   10                  15      


Leu Ala Lys Thr Thr Gln Pro Ile Ser Met Asp Ser Tyr Glu Gly Gln 
            20                  25                  30          


Glu Val Asn Ile Thr Cys Ser His Asn Asn Ile Ala Thr Asn Asp Tyr 
        35                  40                  45              


Ile Thr Trp Tyr Gln Gln Phe Pro Ser Gln Gly Pro Arg Phe Ile Ile 
    50                  55                  60                  


Gln Gly Tyr Lys Thr Lys Val Thr Asn Glu Val Ala Ser Leu Phe Ile 
65                  70                  75                  80  


Pro Ala Asp Arg Lys Ser Ser Thr Leu Ser Leu Pro Arg Val Ser Leu 
                85                  90                  95      


Ser Asp Thr Ala Val Tyr Tyr Cys Leu Val Gly Asp Ala Pro Asn Ser 
            100                 105                 110         


Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser Val Ile 
        115                 120                 125             


Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala 
            260                 265                 270         


Lys Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        275                 280                 285             


Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Leu Leu Leu Leu 
    290                 295                 300                 


Gly Pro Gly Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Arg 
305                 310                 315                 320 


Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu 
                325                 330                 335     


Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Lys 
            340                 345                 350         


Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr 
        355                 360                 365             


Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu 
    370                 375                 380                 


Thr Leu Ser Thr Leu Thr Val Thr Ser Ala Gln Pro Glu Asp Ser Ser 
385                 390                 395                 400 


Phe Tyr Ile Cys Ser Ala His Thr Arg Ala Asn Tyr Gly Tyr Thr Phe 
                405                 410                 415     


Gly Ser Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe 
            420                 425                 430         


Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His 
        435                 440                 445             


Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp 
                485                 490                 495     


Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
            500                 505                 510         


Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu 
        515                 520                 525             


Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln 
    530                 535                 540                 


Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser 
545                 550                 555                 560 


Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
                565                 570                 575     


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val 
            580                 585                 590         


Leu Met Ala Met Val Lys Arg Lys Asp Phe 
        595                 600         


<210> 2
<211> 618
<212> PRT
<213> Homo sapiens

<400> 2
Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu Ala 
1               5                   10                  15      


Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser Ile 
            20                  25                  30          


Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser Ile 
        35                  40                  45              


Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val His 
    50                  55                  60                  


Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg Leu 
65                  70                  75                  80  


Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile Thr 
                85                  90                  95      


Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp Thr 
            100                 105                 110         


Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu Lys 
        115                 120                 125             


Val Leu Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Arg Ala Lys Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Leu Leu 
    290                 295                 300                 


Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu Pro Gly Ser Leu Ala Gly 
305                 310                 315                 320 


Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys 
                325                 330                 335     


Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln 
            340                 345                 350         


Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met 
        355                 360                 365             


Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly 
    370                 375                 380                 


Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser 
385                 390                 395                 400 


Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile 
                405                 410                 415     


Cys Ser Ala Arg Asp Leu Thr Ser Gly Ser Leu Asn Glu Gln Phe Phe 
            420                 425                 430         


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe 
        435                 440                 445             


Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His 
    450                 455                 460                 


Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp 
465                 470                 475                 480 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
                485                 490                 495     


Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp 
            500                 505                 510         


Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
        515                 520                 525             


Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu 
    530                 535                 540                 


Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln 
545                 550                 555                 560 


Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser 
                565                 570                 575     


Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
            580                 585                 590         


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val 
        595                 600                 605             


Leu Met Ala Met Val Lys Arg Lys Asp Phe 
    610                 615             


<210> 3
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (8)..(9)
<223> Inosine

<220>
<221> modified_base
<222> (13)..(14)
<223> Inosine

<220>
<221> modified_base
<222> (18)..(19)
<223> Inosine

<400> 3
caccgggnng ggnngggnn                                                    19


<210> 4
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 4
agtcagattt gttgctccag gcc                                               23


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
ttcacccacc agctcagctc c                                                 21


<210> 6
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
atacgcgttc tctcagctgg tacacgg                                           27


<210> 7
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
atacgcgtag atctctgctt ctgatggc                                          28


<210> 8
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
tttttttttt                                                              10


<210> 9
<211> 16
<212> PRT
<213> Homo sapiens

<400> 9
Cys Leu Val Gly Asp Ala Pro Asn Ser Gly Asn Thr Pro Leu Val Ser 
1               5                   10                  15      


<210> 10
<211> 13
<212> PRT
<213> Homo sapiens

<400> 10
Cys Ser Ala His Thr Arg Ala Asn Tyr Gly Tyr Thr Phe 
1               5                   10              



