                               SEQUENCE LISTING

<110> ZYMEWORKS INC.
      NG, GORDON YIU KON

<120> BISPECIFIC HER2/HER3 ANTIBODIES

<130> 30712-24689/PCT

<140>
<141>

<150> 61/821,197
<151> 2013-05-08

<160> 69    

<170> PatentIn version 3.5

<210> 1
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacgttaac accgctgtag cttggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattct gcatcctttt tgtacagtgg ggtcccatca      180

aggttcagtg gcagtcgatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag cattacacta ccccacccac tttcggccaa      300

gggaccaaag tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccaa      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210> 2
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 3
<211> 1350
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
gaggtgcagc tggtggaaag cggaggagga ctggtgcagc caggaggatc tctgcgactg       60

agttgcgccg cttcaggatt caacatcaag gacacctaca ttcactgggt gcgacaggct      120

ccaggaaaag gactggagtg ggtggctcga atctatccca ctaatggata cacccggtat      180

gccgactccg tgaaggggag gtttactatt agcgccgata catccaaaaa cactgcttac      240

ctgcagatga acagcctgcg agccgaagat accgctgtgt actattgcag tcgatgggga      300

ggagacggat tctacgctat ggattattgg ggacagggga ccctggtgac agtgagctcc      360

gcctctacca agggccccag tgtgtttccc ctggctcctt ctagtaaatc cacctctgga      420

gggacagccg ctctgggatg tctggtgaag gactatttcc ccgagcctgt gaccgtgagt      480

tggaactcag gcgccctgac aagcggagtg cacacttttc ctgctgtgct gcagtcaagc      540

gggctgtact ccctgtcctc tgtggtgaca gtgccaagtt caagcctggg cacacagact      600

tatatctgca acgtgaatca taagccctca aatacaaaag tggacaagaa agtggagccc      660

aagagctgtg ataagaccca cacctgccct ccctgtccag ctccagaact gctgggagga      720

cctagcgtgt tcctgtttcc ccctaagcca aaagacactc tgatgatttc caggactccc      780

gaggtgacct gcgtggtggt ggacgtgtct cacgaggacc ccgaagtgaa gttcaactgg      840

tacgtggatg gcgtggaagt gcataatgct aagacaaaac caagagagga acagtacaac      900

tccacttatc gcgtcgtgag cgtgctgacc gtgctgcacc aggactggct gaacgggaag      960

gagtataagt gcaaagtcag taataaggcc ctgcctgctc caatcgaaaa aaccatctct     1020

aaggccaaag gccagccaag ggagccccag gtgtacacac tgccacccag cagagacgaa     1080

ctgaccaaga accaggtgtc cctgacatgt ctggtgaaag gcttctatcc tagtgatatt     1140

gctgtggagt gggaatcaaa tggacagcca gagaacaatt acaagaccac acctccagtg     1200

ctggacagcg atggcagctt cttcctgtat tccaagctga cagtggataa atctcgatgg     1260

cagcagggga acgtgtttag ttgttcagtg atgcatgaag ccctgcacaa tcattacact     1320

cagaagagcc tgtccctgtc tcccggcaaa                                      1350


<210> 4
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 5
<211> 1350
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
gaggtgcagc tggtggaaag cggaggagga ctggtgcagc caggaggatc tctgcgactg       60

agttgcgccg cttcaggatt caacatcaag gacacctaca ttcactgggt gcgacaggct      120

ccaggaaaag gactggagtg ggtggctcga atctatccca ctaatggata cacccggtat      180

gccgactccg tgaaggggag gtttactatt agcgccgata catccaaaaa cactgcttac      240

ctgcagatga acagcctgcg agccgaagat accgctgtgt actattgcag tcgatgggga      300

ggagacggat tctacgctat ggattattgg ggacagggga ccctggtgac agtgagctcc      360

gcctctacca agggccccag tgtgtttccc ctggctcctt ctagtaaatc cacctctgga      420

gggacagccg ctctgggatg tctggtgaag gactatttcc ccgagcctgt gaccgtgagt      480

tggaactcag gcgccctgac aagcggagtg cacacttttc ctgctgtgct gcagtcaagc      540

gggctgtact ccctgtcctc tgtggtgaca gtgccaagtt caagcctggg cacacagact      600

tatatctgca acgtgaatca taagccctca aatacaaaag tggacaagaa agtggagccc      660

aagagctgtg ataagaccca cacctgccct ccctgtccag ctccagaact gctgggagga      720

cctagcgtgt tcctgtttcc ccctaagcca aaagacactc tgatgatttc caggactccc      780

gaggtgacct gcgtggtggt ggacgtgtct cacgaggacc ccgaagtgaa gttcaactgg      840

tacgtggatg gcgtggaagt gcataatgct aagacaaaac caagagagga acagtacaac      900

tccacttatc gcgtcgtgag cgtgctgacc gtgctgcacc aggactggct gaacgggaag      960

gagtataagt gcaaagtcag taataaggcc ctgcctgctc caatcgaaaa aaccatctct     1020

aaggccaaag gccagccaag ggagccccag gtgtacgtgt acccacccag cagagacgaa     1080

ctgaccaaga accaggtgtc cctgacatgt ctggtgaaag gcttctatcc tagtgatatt     1140

gctgtggagt gggaatcaaa tggacagcca gagaacaatt acaagaccac acctccagtg     1200

ctggacagcg atggcagctt cgccctggtg tccaagctga cagtggataa atctcgatgg     1260

cagcagggga acgtgtttag ttgttcagtg atgcatgaag ccctgcacaa tcattacact     1320

cagaagagcc tgtccctgtc tcccggcaaa                                      1350


<210> 6
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 7
<211> 1350
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
gaggtgcagc tggtggaaag cggaggagga ctggtgcagc caggaggatc tctgcgactg       60

agttgcgccg cttcaggatt caacatcaag gacacctaca ttcactgggt gcgacaggct      120

ccaggaaaag gactggagtg ggtggctcga atctatccca ctaatggata cacccggtat      180

gccgactccg tgaaggggag gtttactatt agcgccgata catccaaaaa cactgcttac      240

ctgcagatga acagcctgcg agccgaagat accgctgtgt actattgcag tcgatgggga      300

ggagacggat tctacgctat ggattattgg ggacagggga ccctggtgac agtgagctcc      360

gcctctacca agggccccag tgtgtttccc ctggctcctt ctagtaaatc cacctctgga      420

gggacagccg ctctgggatg tctggtgaag gactatttcc ccgagcctgt gaccgtgagt      480

tggaactcag gcgccctgac aagcggagtg cacacttttc ctgctgtgct gcagtcaagc      540

gggctgtact ccctgtcctc tgtggtgaca gtgccaagtt caagcctggg cacacagact      600

tatatctgca acgtgaatca taagccctca aatacaaaag tggacaagaa agtggagccc      660

aagagctgtg ataagaccca cacctgccct ccctgtccag ctccagaact gctgggagga      720

cctagcgtgt tcctgtttcc ccctaagcca aaagacactc tgatgatttc caggactccc      780

gaggtgacct gcgtggtggt ggacgtgtct cacgaggacc ccgaagtgaa gttcaactgg      840

tacgtggatg gcgtggaagt gcataatgct aagacaaaac caagagagga acagtacaac      900

tccacttatc gcgtcgtgag cgtgctgacc gtgctgcacc aggactggct gaacgggaag      960

gagtataagt gcaaagtcag taataaggcc ctgcctgctc caatcgaaaa aaccatctct     1020

aaggccaaag gccagccaag ggagccccag gtgtacgtgc tgccacccag cagagacgaa     1080

ctgaccaaga accaggtgtc cctgctgtgt ctggtgaaag gcttctatcc tagtgatatt     1140

gctgtggagt gggaatcaaa tggacagcca gagaacaatt acctgacctg gcctccagtg     1200

ctggacagcg atggcagctt cttcctgtat tccaagctga cagtggataa atctcgatgg     1260

cagcagggga acgtgtttag ttgttcagtg atgcatgaag ccctgcacaa tcattacact     1320

cagaagagcc tgtccctgtc tcccggcaaa                                      1350


<210> 8
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 9
<211> 696
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
gaacctaaat ctagcgacaa gactcacacc tgcccacctt gtccagcacc agaactgctg       60

ggaggaccaa gcgtgttcct gtttccaccc aagcccaaag atactctgat gatcagccga      120

acacccgagg tcacttgcgt ggtcgtggac gtgtcccacg aggaccccga agtcaagttc      180

aactggtacg tggacggcgt cgaagtgcat aatgctaaga caaaaccacg ggaggaacag      240

tacaactcta cttatagagt cgtgagtgtc ctgaccgtgc tgcatcagga ttggctgaac      300

ggcaaagagt ataagtgcaa agtgtctaat aaggccctgc ctgctccaat cgagaaaaca      360

attagtaagg ctaaagggca gcccagggaa cctcaggtgt acacttatcc tccaagtcgc      420

gacgagctga ccaagaacca ggtctcactg acatgtctgg tgaaaggatt ttacccttcc      480

gatattgcag tggagtggga atctaatggc cagccagaga acaattataa gaccacaccc      540

cctgtgctgg acagcgatgg gtccttcgca ctggtctcaa agctgaccgt ggacaaaagc      600

agatggcagc agggaaacgt ctttagctgt tccgtgatgc acgaagccct gcacaatcat      660

tacacacaga agtctctgag tctgtcacct ggcaaa                                696


<210> 10
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Tyr Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 11
<211> 1446
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
caggtccagc tgcaggaatc tggaggagga ctggtgaagc caggagggtc tctgagactg       60

agttgcgccg cttcaggctt cacctttagc tcctactgga tgagctgggt gcggcaggca      120

cctggcaaag gactggagtg ggtggccaac atcaatagag acgggagtgc ttcatactat      180

gtcgatagcg tgaagggaag gttcactatt agtcgcgacg atgcaaaaaa ctcactgtac      240

ctgcagatga atagcctgag ggccgaagac accgctgtct actattgcgc ccgggacaga      300

ggagtgggct attttgatct gtgggggcgc ggaaccctgg tcacagtgtc tagtgcttcc      360

accggaggcg ggggatcagg cggaggaggc agcggaggag gagggagcca gtccgctctg      420

acacagcctg catctgtgag tggctcacca gggcagagca tcactatttc ctgtactggc      480

acctcaagcg atgtcggagg ctacaacttc gtgagctggt atcagcagca cccagggaag      540

gcacccaaac tgatgatcta cgacgtctcc gatcgaccaa gtggagtgtc agaccggttt      600

agcggcagca agtctggcaa tacagcctct ctgatcatta gtggactgca ggcagacgat      660

gaggccgatt actattgctc ctcttatggc agttcaagca ctcacgtgat tttcggggga      720

ggcactaaag tcaccgtgct gggcgcagcc gaacccaagt cctctgacaa aacacatact      780

tgcccacctt gtccagctcc agagctgctg ggaggaccaa gcgtgttcct gtttccaccc      840

aagcctaaag atactctgat gatcagccga acacctgaag tcacttgtgt ggtcgtggac      900

gtgtcccacg aggaccccga agtcaagttt aactggtacg tggacggcgt cgaggtgcat      960

aatgccaaga caaaacctag agaggaacag tacaactcca cttatagggt cgtgtctgtc     1020

ctgaccgtgc tgcaccagga ttggctgaac ggaaaggagt ataagtgcaa agtgtctaat     1080

aaggctctgc ctgcaccaat cgagaaaacc attagcaagg ctaaagggca gccccgcgaa     1140

cctcaggtgt acacactgcc tccatctcga gacgagctga ccaagaacca ggtcagcctg     1200

acatgtctgg tgaaaggctt ctatccaagt gatattgcag tggagtggga atccaatggg     1260

cagcccgaaa acaattacaa gaccacaccc cctgtgctgg acagcgatgg ctccttcttt     1320

ctgtattcca agctgaccgt ggacaaatct cgctggcagc aggggaacgt ctttagttgt     1380

tcagtgatgc atgaggccct gcacaatcat tacacacaga agagcctgtc cctgtctccc     1440

ggcaaa                                                                1446


<210> 12
<211> 482
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly 
145                 150                 155                 160 


Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln 
                165                 170                 175     


His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg 
            180                 185                 190         


Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
        195                 200                 205             


Ala Ser Leu Ile Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ser Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Gly Ala Ala Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys 
        


<210> 13
<211> 1467
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
caggtccagc tggtgcagag cggggcagag gtcaagaaac ccggagaaag tctgaagatc       60

tcatgcaaag ggagtggata ctcattcacc agctattgga ttgcctgggt gaggcagatg      120

cctggcaagg ggctggaata catgggcctg atctatccag gggacagcga tacaaaatac      180

tccccctctt tccagggcca ggtcacaatt tccgtggaca agagtgtctc aactgcctat      240

ctgcagtgga gctccctgaa acctagcgat tccgcagtgt acttttgtgc caggcacgac      300

gtcgggtatt gcacagatcg cacttgtgct aagtggccag agtggctggg agtgtgggga      360

cagggaaccc tggtcacagt gtctagtgga ggaggaggct caagcggagg aggctctgga      420

ggaggagggt ctcagagtgt gctgactcag ccaccttcag tcagcgcagc tcctggacag      480

aaggtgacca tctcctgctc tggcagctct agtaacattg gcaacaatta cgtgagctgg      540

tatcagcagc tgcctggcac cgccccaaag ctgctgatct acgaccacac aaatcggccc      600

gctggggtgc ctgatagatt cagtgggtca aaaagcggaa cctccgcttc tctggcaatt      660

agcggctttc gctccgagga cgaagctgat tactattgtg catcttggga ctacacactg      720

agtggctggg tgttcggagg cgggactaag ctgaccgtgc tgggggcagc cgaaccaaag      780

tcaagcgata aaactcatac ctgcccacca tgtcctgcac cagagctgct gggaggacct      840

tccgtgttcc tgtttcctcc aaagccaaaa gacaccctga tgatcagccg aacaccagaa      900

gtgacttgcg tggtcgtgga cgtctcccac gaggaccccg aagtgaagtt taactggtac      960

gtggatggcg tcgaggtgca taatgccaag accaaacccc gagaggaaca gtacaactca     1020

acttatcggg tcgtgagcgt cctgaccgtg ctgcaccagg actggctgaa cgggaaagag     1080

tataagtgca aagtgtctaa taaggccctg cccgctccta tcgagaaaac aattagcaag     1140

gcaaaaggcc agccaagaga accccaggtg tacacttatc ccccttctag ggacgagctg     1200

accaagaacc aggtgagcct gacatgtctg gtcaaaggat tttaccccag tgatattgct     1260

gtggagtggg aatccaatgg ccagcctgaa aacaattata agaccacacc acccgtgctg     1320

gactccgatg gatctttcgc tctggtgtcc aagctgactg tcgataaatc tcggtggcag     1380

cagggcaacg tgtttagttg ttcagtcatg catgaggcac tgcacaatca ttacacacag     1440

aagagcctgt ccctgtctcc cggcaaa                                         1467


<210> 14
<211> 489
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Tyr Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Pro Ser Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Asp Val Gly Tyr Cys Thr Asp Arg Thr Cys Ala Lys Trp 
            100                 105                 110         


Pro Glu Trp Leu Gly Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
145                 150                 155                 160 


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
                165                 170                 175     


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
            180                 185                 190         


Ile Tyr Asp His Thr Asn Arg Pro Ala Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Phe Arg 
    210                 215                 220                 


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Tyr Thr Leu 
225                 230                 235                 240 


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala 
                245                 250                 255     


Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    290                 295                 300                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
305                 310                 315                 320 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                325                 330                 335     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            340                 345                 350         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        355                 360                 365             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    370                 375                 380                 


Pro Arg Glu Pro Gln Val Tyr Thr Tyr Pro Pro Ser Arg Asp Glu Leu 
385                 390                 395                 400 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                405                 410                 415     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            420                 425                 430         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu 
        435                 440                 445             


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    450                 455                 460                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
465                 470                 475                 480 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 


<210> 15
<211> 1446
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
caggtccagc tgcaggaatc tggaggagga ctggtgaagc caggagggtc tctgagactg       60

agttgcgccg cttcaggctt cacctttagc tcctactgga tgagctgggt gcggcaggca      120

cctggcaaag gactggagtg ggtggccaac atcaatagag acgggagtgc ttcatactat      180

gtcgatagcg tgaagggaag gttcaccatt agtcgcgacg atgcaaaaaa ctcactgtac      240

ctgcagatga atagcctgag ggccgaagac acagctgtct actattgcgc ccgggacaga      300

ggagtgggct attttgatct gtgggggcgc ggaacactgg tcactgtgtc tagtgcttcc      360

acaggaggcg ggggatcagg cggaggaggc agcggaggag gagggagcca gtccgctctg      420

actcagcctg catctgtgag tggctcacca gggcagagca tcaccatttc ctgtaccggc      480

acatcaagcg atgtcggagg ctacaacttc gtgagctggt atcagcagca cccagggaag      540

gcacccaaac tgatgatcta cgacgtctcc gatcgaccaa gtggagtgtc agaccggttt      600

agcggcagca agtctggcaa tactgcctct ctgatcatta gtggactgca ggcagacgat      660

gaggccgatt actattgctc ctcttatggc agttcaagca cccacgtgat tttcggggga      720

ggcaccaagg tcacagtgct gggcgcagcc gaacccaagt cctctgacaa aactcatacc      780

tgcccacctt gtccagctcc agagctgctg ggaggaccaa gcgtgttcct gtttccaccc      840

aagcctaaag atacactgat gatcagccga actcctgaag tcacctgtgt ggtcgtggac      900

gtgtcccacg aggaccccga agtcaagttt aactggtacg tggacggcgt cgaggtgcat      960

aatgccaaga ctaaacctag agaggaacag tacaactcca catatagggt cgtgtctgtc     1020

ctgactgtgc tgcaccagga ttggctgaac ggaaaggagt ataagtgcaa agtgtctaat     1080

aaggctctgc ctgcaccaat cgagaaaacc attagcaagg ctaaagggca gccccgcgaa     1140

cctcaggtgt acaccctgcc tccatctcga gacgagctga caaagaacca ggtcagcctg     1200

ctgtgtctgg tgaaaggctt ctatccaagt gatattgcag tggagtggga atccaatggg     1260

cagcccgaaa acaattacat gacatggccc cctgtgctgg acagcgatgg ctccttcttt     1320

ctgtattcca agctgactgt ggacaaatct cgctggcagc aggggaacgt ctttagttgt     1380

tcagtgatgc atgaggccct gcacaatcat tacacccaga agagcctgtc cctgtctccc     1440

ggcaaa                                                                1446


<210> 16
<211> 482
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly 
145                 150                 155                 160 


Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln 
                165                 170                 175     


His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg 
            180                 185                 190         


Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
        195                 200                 205             


Ala Ser Leu Ile Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ser Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Gly Ala Ala Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Met Thr Trp Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys 
        


<210> 17
<211> 3285
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
caggtgcagc tgcaggagtc cggaggagga ctggtgaagc caggagggtc cctgagactg       60

tcttgcgccg ctagtggctt cacctttagc tcctactgga tgtcttgggt gaggcaggca      120

cctggcaagg gactggagtg ggtggcaaac atcaatcgcg acggatcagc cagctactat      180

gtggatagcg tcaagggcag gtttacaatt agtcgcgacg atgctaaaaa ctcactgtac      240

ctgcagatga atagcctgcg ggcagaggat actgccgtgt actattgcgc cagagacagg      300

ggagtcggct atttcgatct gtgggggaga ggaactctgg tgaccgtctc tagtgctagc      360

accggaggcg ggggatctgg cggaggaggc agtggaggag gagggtccca gtctgctctg      420

acacagccag caagtgtgtc aggcagcccc gggcagtcaa tcactattag ctgtactggc      480

acctcaagcg acgtgggagg ctacaacttt gtcagctggt atcagcagca ccctggaaaa      540

gccccaaagc tgatgatcta cgacgtgagc gatcgacctt ccggcgtctc tgatcggttc      600

tccgggtcta agagtggaaa tactgcctcc ctgatcattt ctgggctgca ggctgacgat      660

gaggcagact actattgctc ctcttatgga agttcaagca cccatgtgat cttcggggga      720

ggcacaaaag tgactgtcct gggcgcagcc tcagatgctc acaaaagcga ggtggcacat      780

cggttcaagg acctggggga ggaaaacttt aaagccctgg tgctgattgc attcgcccag      840

tacctgcagc agagcccatt tgaggaccac gtgaagctgg tcaacgaggt gaccgagttc      900

gccaaaacat gcgtggccga cgagtccgct gaaaattgtg ataagtctct gcatactctg      960

tttggagata aactgtgcac cgtggccaca ctgcgagaga cctacggcga aatggcagac     1020

tgctgtgcca agcaggagcc agaaagaaac gagtgcttcc tgcagcacaa agacgataac     1080

ccaaatctgc cacgactggt gcgaccagaa gtggacgtca tgtgtactgc tttccacgat     1140

aatgaggaaa cctttctgaa gaaatacctg tatgagatcg cccggagaca tccctacttt     1200

tatgcacctg aactgctgtt ctttgccaaa agatacaagg ctgcattcac cgagtgctgt     1260

caggccgctg ataaagcagc ctgcctgctg ccaaagctgg acgagctgcg agatgaaggc     1320

aaggcctcct ctgctaaaca gagactgaag tgtgccagcc tgcagaaatt cggcgagagg     1380

gcttttaagg cttgggcagt ggcacgactg tcccagagat tccctaaggc agagtttgcc     1440

gaagtctcta aactggtgac tgacctgacc aaggtgcaca ccgagtgctg tcatggcgac     1500

ctgctggaat gcgccgacga tcgcgctgat ctggcaaagt acatctgtga gaaccaggac     1560

agcattagtt caaagctgaa agagtgctgt gaaaaacccc tgctggagaa gagccactgc     1620

atcgcagagg tggaaaacga cgaaatgccc gccgatctgc ctagtctggc tgcagacttc     1680

gtggagtcaa aagatgtctg taagaattac gctgaagcaa aggatgtgtt cctgggcatg     1740

tttctgtacg agtatgctag gcgccaccca gactactccg tggtcctgct gctgaggctg     1800

gccaagacct atgagaccac actggaaaaa tgctgtgccg ctgcagatcc ccatgagtgc     1860

tatgccaaag tgttcgacga gttcaagcca ctggtcgagg aaccccagaa cctgattaag     1920

cagaattgtg agctgtttga acagctgggc gagtacaaat tccagaacgc cctgctggtg     1980

cgctatacaa agaaagtccc tcaggtgagc acaccaactc tggtggaagt ctccaggaat     2040

ctgggaaagg tcggctctaa atgctgtaag caccccgagg ccaaacgcat gccttgcgct     2100

gaagattacc tgtccgtggt cctgaaccag ctgtgtgtgc tgcatgagaa gaccccagtc     2160

tctgaccggg tgacaaaatg ctgtactgaa agtctggtga atcgacggcc ctgctttagc     2220

gccctggagg tggatgaaac atatgtccct aaggagttcc aggctgaaac cttcacattt     2280

cacgcagaca tctgtactct gtccgagaaa gaaagacaga ttaagaaaca gaccgccctg     2340

gtcgagctgg tgaagcataa acccaaggcc acaaaagaac agctgaaggc tgtgatggac     2400

gatttcgccg cttttgtcga gaaatgctgt aaggctgacg ataaggaaac ttgctttgca     2460

gaggaaggga agaaactggt ggcagcatcc caggctgcac tgggactggc agctgcactg     2520

caggtccagc tggtgcagtc tggcgccgag gtgaagaaac ctggggaaag tctgaaaatc     2580

tcctgtaagg gcagtgggta ctcattcacc agctattgga ttgcctgggt gaggcagatg     2640

ccaggaaagg gcctggagta catgggactg atctatcctg gcgacagcga tacaaaatac     2700

tcaccaagct ttcagggcca ggtcacaatt agcgtggata agtccgtctc tactgcctat     2760

ctgcagtgga gctccctgaa acctagtgac tcagccgtgt acttctgcgc tcgccacgac     2820

gtcggctatt gcacagatcg aacttgtgcc aagtggccag agtggctggg agtgtgggga     2880

cagggaaccc tggtgacagt ctctagtggg ggaggcgggt caagcggagg agggtccgga     2940

ggaggaggaa gccagtccgt gctgacccag cccccttctg tcagtgccgc tcctggccag     3000

aaggtgacaa tctcatgcag cgggtcctct agtaacattg gaaacaatta cgtgagctgg     3060

tatcagcagc tgccagggac cgctcccaag ctgctgatct acgatcatac aaatagacct     3120

gcaggagtgc cagacaggtt ttccggctct aaaagtggga cctcagccag cctggctatt     3180

agcggcttcc ggtccgagga cgaagcagat tactattgtg cctcctggga ctatacactg     3240

tctggctggg tgttcggcgg gggaactaag ctgaccgtcc tgggg                     3285


<210> 18
<211> 1095
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly 
145                 150                 155                 160 


Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln 
                165                 170                 175     


His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg 
            180                 185                 190         


Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
        195                 200                 205             


Ala Ser Leu Ile Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ser Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Gly Ala Ala Ser Asp Ala His Lys Ser 
                245                 250                 255     


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
            260                 265                 270         


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu 
        275                 280                 285             


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
    290                 295                 300                 


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
305                 310                 315                 320 


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
                325                 330                 335     


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
            340                 345                 350         


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
        355                 360                 365             


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
    370                 375                 380                 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
385                 390                 395                 400 


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
                405                 410                 415     


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
            420                 425                 430         


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
        435                 440                 445             


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
    450                 455                 460                 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
465                 470                 475                 480 


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
                485                 490                 495     


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
            500                 505                 510         


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
        515                 520                 525             


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
    530                 535                 540                 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
545                 550                 555                 560 


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
                565                 570                 575     


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
            580                 585                 590         


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
        595                 600                 605             


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
    610                 615                 620                 


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
625                 630                 635                 640 


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
                645                 650                 655     


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
            660                 665                 670         


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
        675                 680                 685             


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
    690                 695                 700                 


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
705                 710                 715                 720 


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
                725                 730                 735     


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
            740                 745                 750         


Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
        755                 760                 765             


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
    770                 775                 780                 


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
785                 790                 795                 800 


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
                805                 810                 815     


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
            820                 825                 830         


Ala Leu Gly Leu Ala Ala Ala Leu Gln Val Gln Leu Val Gln Ser Gly 
        835                 840                 845             


Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly 
    850                 855                 860                 


Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Ala Trp Val Arg Gln Met 
865                 870                 875                 880 


Pro Gly Lys Gly Leu Glu Tyr Met Gly Leu Ile Tyr Pro Gly Asp Ser 
                885                 890                 895     


Asp Thr Lys Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Val 
            900                 905                 910         


Asp Lys Ser Val Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Pro 
        915                 920                 925             


Ser Asp Ser Ala Val Tyr Phe Cys Ala Arg His Asp Val Gly Tyr Cys 
    930                 935                 940                 


Thr Asp Arg Thr Cys Ala Lys Trp Pro Glu Trp Leu Gly Val Trp Gly 
945                 950                 955                 960 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Ser Gly 
                965                 970                 975     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro 
            980                 985                 990         


Ser Val Ser Ala Ala Pro Gly Gln  Lys Val Thr Ile Ser  Cys Ser Gly 
        995                 1000                 1005             


Ser Ser  Ser Asn Ile Gly Asn  Asn Tyr Val Ser Trp  Tyr Gln Gln 
    1010                 1015                 1020             


Leu Pro  Gly Thr Ala Pro Lys  Leu Leu Ile Tyr Asp  His Thr Asn 
    1025                 1030                 1035             


Arg Pro  Ala Gly Val Pro Asp  Arg Phe Ser Gly Ser  Lys Ser Gly 
    1040                 1045                 1050             


Thr Ser  Ala Ser Leu Ala Ile  Ser Gly Phe Arg Ser  Glu Asp Glu 
    1055                 1060                 1065             


Ala Asp  Tyr Tyr Cys Ala Ser  Trp Asp Tyr Thr Leu  Ser Gly Trp 
    1070                 1075                 1080             


Val Phe  Gly Gly Gly Thr Lys  Leu Thr Val Leu Gly  
    1085                 1090                 1095 


<210> 19
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
gatattcaga tgacccagtc cccaagctcc ctgagtgcct cagtgggcga ccgagtcacc       60

atcacatgca aggcttccca ggatgtgtct attggagtcg catggtacca gcagaagcca      120

ggcaaagcac ccaagctgct gatctatagc gcctcctacc ggtataccgg cgtgccctct      180

agattctctg gcagtgggtc aggaacagac tttactctga ccatctctag tctgcagcct      240

gaggatttcg ctacctacta ttgccagcag tactatatct acccatatac ctttggccag      300

gggacaaaag tggagatcaa gaggactgtg gccgctccct ccgtcttcat ttttccccct      360

tctgacgaac agctgaaaag tggcacagcc agcgtggtct gtctgctgaa caatttctac      420

cctcgcgaag ccaaagtgca gtggaaggtc gataacgctc tgcagagcgg caacagccag      480

gagtctgtga ctgaacagga cagtaaagat tcaacctata gcctgtcaag cacactgact      540

ctgagcaagg cagactacga gaagcacaaa gtgtatgcct gcgaagtcac acatcagggg      600

ctgtcctctc ctgtgactaa gagctttaac agaggagagt gt                         642


<210> 20
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 21
<211> 1344
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
gaagtgcagc tggtcgaatc tggaggagga ctggtgcagc caggagggtc cctgcgcctg       60

tcttgcgccg ctagtggctt cacttttacc gactacacca tggattgggt gcgacaggca      120

cctggaaagg gcctggagtg ggtcgccgat gtgaacccaa atagcggagg ctccatctac      180

aaccagcggt tcaagggccg gttcaccctg tcagtggacc ggagcaaaaa caccctgtat      240

ctgcagatga atagcctgcg agccgaagat actgctgtgt actattgcgc ccggaatctg      300

gggccctcct tctactttga ctattggggg cagggaactc tggtcaccgt gagctccgcc      360

tccaccaagg gaccttctgt gttcccactg gctccctcta gtaaatccac atctggggga      420

actgcagccc tgggctgtct ggtgaaggac tacttcccag agcccgtcac agtgtcttgg      480

aacagtggcg ctctgacttc tggggtccac acctttcctg cagtgctgca gtcaagcggg      540

ctgtacagcc tgtcctctgt ggtcaccgtg ccaagttcaa gcctgggaac acagacttat      600

atctgcaacg tgaatcacaa gccatccaat acaaaagtcg acaagaaagt ggaacccaag      660

tcttgtgata aaacccatac atgcccccct tgtcctgcac cagagctgct gggaggacca      720

agcgtgttcc tgtttccacc caagcctaaa gatacactga tgattagtag gaccccagaa      780

gtcacatgcg tggtcgtgga cgtgagccac gaggaccccg aagtcaagtt taactggtac      840

gtggacggcg tcgaggtgca taatgccaag actaaaccca gggaggaaca gtacaacagt      900

acctatcgcg tcgtgtcagt cctgacagtg ctgcatcagg attggctgaa cgggaaagag      960

tataagtgca aagtgagcaa taaggctctg cccgcaccta tcgagaaaac aatttccaag     1020

gcaaaaggac agcctagaga accacaggtg tacgtgctgc ctccatcaag ggatgagctg     1080

acaaagaacc aggtcagcct gctgtgtctg gtgaaaggat tctatccctc tgacattgct     1140

gtggagtggg aaagtaatgg ccagcctgag aacaattacc tgacctggcc ccctgtgctg     1200

gactcagatg gcagcttctt tctgtatagc aagctgaccg tcgacaaatc ccggtggcag     1260

caggggaatg tgtttagttg ttcagtcatg cacgaggcac tgcacaacca ttacacccag     1320

aagtcactgt cactgtcacc aggg                                            1344


<210> 22
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210> 23
<211> 1344
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
gaagtgcagc tggtcgaatc tggaggagga ctggtgcagc caggagggtc cctgcgcctg       60

tcttgcgccg ctagtggctt cacttttacc gactacacca tggattgggt gcgacaggca      120

cctggaaagg gcctggagtg ggtcgccgat gtgaacccaa atagcggagg ctccatctac      180

aaccagcggt tcaagggccg gttcaccctg tcagtggacc ggagcaaaaa caccctgtat      240

ctgcagatga atagcctgcg agccgaagat actgctgtgt actattgcgc ccggaatctg      300

gggccctcct tctactttga ctattggggg cagggaactc tggtcaccgt gagctccgcc      360

tccaccaagg gaccttctgt gttcccactg gctccctcta gtaaatccac atctggggga      420

actgcagccc tgggctgtct ggtgaaggac tacttcccag agcccgtcac agtgtcttgg      480

aacagtggcg ctctgacttc tggggtccac acctttcctg cagtgctgca gtcaagcggg      540

ctgtacagcc tgtcctctgt ggtcaccgtg ccaagttcaa gcctgggaac acagacttat      600

atctgcaacg tgaatcacaa gccatccaat acaaaagtcg acaagaaagt ggaacccaag      660

tcttgtgata aaacccatac atgcccccct tgtcctgcac cagagctgct gggaggacca      720

agcgtgttcc tgtttccacc caagcctaaa gatacactga tgattagtag gaccccagaa      780

gtcacatgcg tggtcgtgga cgtgagccac gaggaccccg aagtcaagtt taactggtac      840

gtggacggcg tcgaggtgca taatgccaag actaaaccca gggaggaaca gtacaacagt      900

acctatcgcg tcgtgtcagt cctgacagtg ctgcatcagg attggctgaa cgggaaagag      960

tataagtgca aagtgagcaa taaggctctg cccgcaccta tcgagaaaac aatttccaag     1020

gcaaaaggac agcctagaga accacaggtg tacgtgtatc ctccatcaag ggatgagctg     1080

acaaagaacc aggtcagcct gacttgtctg gtgaaaggat tctatccctc tgacattgct     1140

gtggagtggg aaagtaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gactcagatg gcagcttcgc gctggtgagc aagctgaccg tcgacaaatc ccggtggcag     1260

caggggaatg tgtttagttg ttcagtcatg cacgaggcac tgcacaacca ttacacccag     1320

aagtcactgt cactgtcacc aggg                                            1344


<210> 24
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210> 25
<211> 1350
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
gaagtccagc tggtcgaaag cggaggagga ctggtgcagc caggagggtc tctgcgactg       60

agttgcgccg cttcaggctt caacatcaag gacacctaca ttcactgggt gcgccaggct      120

cctggaaaag gcctggagtg ggtggcacga atctatccaa ctaatggata cacccggtat      180

gcagacagcg tgaagggccg gttcaccatt agcgcagata catccaaaaa cactgcctac      240

ctgcagatga acagcctgcg agccgaagat actgctgtgt actattgcag tcggtgggga      300

ggcgacggct tctacgctat ggattattgg gggcagggaa ccctggtcac agtgagctcc      360

gcatctacaa aggggcctag tgtgtttcca ctggccccct ctagtaaatc cacctctggg      420

ggaacagcag ccctgggatg tctggtgaag gactatttcc cagagcccgt cactgtgagt      480

tggaactcag gcgccctgac atccggggtc catacttttc ctgctgtgct gcagtcaagc      540

ggcctgtact ctctgtcctc tgtggtcacc gtgccaagtt caagcctggg gactcagacc      600

tatatctgca acgtgaatca caagccaagc aatacaaaag tcgacaagaa agtggaaccc      660

aagagctgtg ataaaacaca tacttgcccc ccttgtcctg caccagagct gctgggagga      720

ccatccgtgt tcctgtttcc acccaagcct aaagacaccc tgatgatttc caggactcca      780

gaagtcacct gcgtggtcgt ggacgtgtct cacgaggacc ccgaagtcaa gttcaactgg      840

tacgtggatg gcgtcgaggt gcataatgcc aagacaaaac ccagggagga acagtacaac      900

tcaacttatc gcgtcgtgag cgtcctgacc gtgctgcacc aggactggct gaacggcaag      960

gagtataagt gcaaagtgag caataaggct ctgcccgcac ctatcgagaa aaccattagc     1020

aaggccaaag ggcagcctag agaaccacag gtctacgtgt atcctccaag cagggacgag     1080

ctgaccaaga accaggtctc cctgacatgt ctggtgaaag ggttttaccc cagtgatatc     1140

gctgtggagt gggaatcaaa tggacagcct gaaaacaatt ataagaccac accccctgtg     1200

ctggacagcg atggcagctt cgctctggtc tccaagctga ctgtggataa atctcggtgg     1260

cagcagggca acgtctttag ttgttcagtg atgcatgagg cactgcacaa tcattacacc     1320

cagaagagcc tgtccctgtc tcccggcaaa                                      1350


<210> 26
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 27
<211> 696
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
gaacctaaaa gcagcgacaa gacccacaca tgcccccctt gtccagctcc agaactgctg       60

ggaggaccaa gcgtgttcct gtttccaccc aagcccaaag atacactgat gatcagccga      120

actcccgagg tcacctgcgt ggtcgtggac gtgtcccacg aggaccccga agtcaagttc      180

aactggtacg tggacggcgt cgaagtgcat aatgcaaaga ctaaaccacg ggaggaacag      240

tacaactcta catatagagt cgtgagtgtc ctgactgtgc tgcatcagga ttggctgaac      300

ggcaaagagt ataagtgcaa agtgtctaat aaggccctgc ctgctccaat cgagaaaact      360

attagtaagg caaaagggca gcccagggaa cctcaggtct acgtgctgcc tccaagtcgc      420

gacgagctga ccaagaacca ggtctcactg ctgtgtctgg tgaaaggatt ctatccttcc      480

gatattgccg tggagtggga atctaatggc cagccagaga acaattacct gacctggccc      540

cctgtgctgg acagcgatgg gtccttcttt ctgtattcaa agctgacagt ggacaaaagc      600

agatggcagc agggaaacgt ctttagctgt tccgtgatgc acgaagccct gcacaatcat      660

tacacccaga agtctctgag tctgtcacct ggcaaa                                696


<210> 28
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Leu Thr Trp Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 29
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
gatattcaga tgacccagtc ccctagctcc ctgtccgctt ctgtgggcga cagggtcact       60

atcacctgcc gcgcatctca ggatgtgaac accgcagtcg cctggtacca gcagaagcct      120

gggaaagctc caaagctgct gatctacagt gcatcattcc tgtattcagg agtgcccagc      180

cggtttagcg gcagcagatc tggcaccgac ttcacactga ctatctctag tctgcagcct      240

gaggattttg ccacatacta ttgccagcag cactatacca caccccctac tttcggccag      300

gggaccaaag tggagatcaa gcgaactgtg gccgctccaa gtgtcttcat ttttccaccc      360

agcgacgaac agctgaaatc cggcacagct tctgtggtct gtctgctgaa caacttctac      420

cccagagagg ccaaagtgca gtggaaggtc gataacgctc tgcagagtgg caacagccag      480

gagagcgtga cagaacagga ctccaaagat tctacttata gtctgtcaag caccctgaca      540

ctgagcaagg cagactacga aaagcataaa gtgtatgcct gtgaggtgac ccatcagggg      600

ctgtcttctc ccgtgaccaa gtctttcaac cgaggcgaat gt                         642


<210> 30
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 31
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
gacatccaga tgacacagtc ccccagctcc ctgagtgcat cagtgggcga cagggtcaca       60

attacttgcc gcgcttccca ggatgtgaac accgctgtcg catggtacca gcagaagcct      120

ggaaaagcac caaagctgct gatctacagc gcctccttcc tgtattccgg cgtgccctct      180

cggttttctg gaagtagatc aggcacagac ttcaccctga caatttctag tctgcagcct      240

gaggattttg ccacttacta ttgccagcag cactatacca caccccctac attcggccag      300

gggactaaag tggagatcaa gcgaaccgtg gccgctcctt ccgtcttcat ttttccaccc      360

tctgacgaac agctgaaaag tgggacagcc tcagtggtct gtctgctgaa caatttttac      420

ccaagagaag ctaaagtgca gtggaaggtc gataacgcac tgcagagcgg caattcccag      480

gagtctgtga ccgaacagga cagtaaagat tcaacatata gcctgtcaag cactctgacc      540

ctgtctaagg ccgattacga gaagcacaaa gtgtatgctt gcgaagtcac tcatcagggc      600

ctgtcctctc ccgtgaccaa gagcttcaat cggggggagt gt                         642


<210> 32
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 33
<211> 1347
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
gaagtccagc tggtcgaaag cggaggagga ctggtgcagc caggagggtc tctgcgactg       60

agttgcgccg cttcaggctt caacatcaag gacacctaca ttcactgggt gcgccaggct      120

cctggaaaag gcctggagtg ggtggcacga atctatccaa ctaatggata cacccggtat      180

gcagacagcg tgaagggccg gttcaccatt agcgcagata catccaaaaa cactgcctac      240

ctgcagatga acagcctgcg agccgaagat actgctgtgt actattgcag tcggtgggga      300

ggcgacggct tctacgctat ggattattgg gggcagggaa ccctggtcac agtgagctcc      360

gcatctacaa aggggcctag tgtgtttcca ctggccccct ctagtaaatc cacctctggg      420

ggaacagcag ccctgggatg tctggtgaag gactatttcc cagagcccgt cactgtgagt      480

tggaactcag gcgccctgac atccggggtc catacttttc ctgctgtgct gcagtcaagc      540

ggcctgtact ctctgtcctc tgtggtcacc gtgccaagtt caagcctggg gactcagacc      600

tatatctgca acgtgaatca caagccaagc aatacaaaag tcgacaagaa agtggaaccc      660

aagagctgtg ataaaacaca tacttgcccc ccttgtcctg caccagagct gctgggagga      720

ccatccgtgt tcctgtttcc acccaagcct aaagacaccc tgatgatttc caggactcca      780

gaagtcacct gcgtggtcgt ggacgtgtct cacgaggacc ccgaagtcaa gttcaactgg      840

tacgtggatg gcgtcgaggt gcataatgcc aagacaaaac ccagggagga acagtacaac      900

tcaacttatc gcgtcgtgag cgtcctgacc gtgctgcacc aggactggct gaacggcaaa      960

gagtataagt gcaaagtgag caataaggct ctgcccgcac ctatcgagaa aaccattagc     1020

aaggccaaag ggcagcctag agaaccacag gtctacgtgt atcctccaag cagggacgag     1080

ctgaccaaga accaggtctc cctgacatgt ctggtgaaag ggttttaccc cagtgatatc     1140

gctgtggagt gggaatcaaa tggacagcct gaaaacaatt ataagaccac accccctgtg     1200

ctggacagcg atggcagctt cgctctggtc tccaagctga ctgtggataa atctcggtgg     1260

cagcagggca acgtctttag ttgttcagtg atgcatgagg cactgcacaa tcattacacc     1320

cagaagagcc tgtccctgtc tcccggc                                         1347


<210> 34
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210> 35
<211> 1440
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 35
gacattcaga tgacacagag ccccagctcc ctgagtgctt cagtcggcga cagggtgact       60

atcacctgcc gcgcatccca ggatgtcaac accgctgtgg catggtacca gcagaagcct      120

ggaaaagccc caaagctgct gatctacagc gcttccttcc tgtattctgg cgtgccaagt      180

cggttttctg gaagtagatc aggcactgac ttcacactga ctatctctag tctgcagccc      240

gaagattttg ccacctacta ttgccagcag cactatacca caccccctac attcggacag      300

ggcactaaag tggagattaa gggcgggtca ggcggaggga gcggaggagg gtccggagga      360

gggtctggag gagggagtgg agaggtccag ctggtggaat ctggaggagg actggtgcag      420

cctggaggct cactgcgact gagctgtgcc gcttccggct ttaacatcaa agacacatac      480

attcattggg tcaggcaggc accagggaag ggactggaat gggtggcccg catctatccc      540

acaaatgggt acactcgata tgccgacagc gtgaaaggac ggtttaccat ttctgctgat      600

accagtaaga acacagcata cctgcagatg aacagcctgc gcgcagagga tacagccgtg      660

tactattgca gtcgatgggg gggagacggc ttctacgcca tggattattg gggccagggg      720

actctggtca ccgtgtcaag cgcagccgaa cctaaatcct ctgacaagac ccacacatgc      780

ccaccctgtc ctgctccaga gctgctggga ggaccatccg tgttcctgtt tcctccaaag      840

cctaaagata cactgatgat tagccgcact cccgaagtca cctgtgtggt cgtggacgtg      900

tcccacgagg accccgaagt caagttcaac tggtacgtgg acggcgtcga ggtgcataat      960

gccaagacta aaccaagaga ggaacagtac aattcaacct atagggtcgt gagcgtcctg     1020

acagtgctgc atcaggattg gctgaacggc aaggagtata agtgcaaagt gtctaacaag     1080

gccctgcccg ctcctatcga gaagactatt agcaaggcaa aagggcagcc acgggaaccc     1140

caggtctacg tgctgccccc tagcagagac gagctgacca aaaaccaggt ctccctgctg     1200

tgtctggtga agggctttta tcctagtgat atcgctgtgg agtgggaatc aaatgggcag     1260

ccagaaaaca attacctgac atggccaccc gtgctggaca gcgatgggtc cttctttctg     1320

tattccaaac tgactgtgga caagtctaga tggcagcagg gaaacgtctt cagctgttcc     1380

gtgatgcacg aggccctgca caatcattac acccagaagt ctctgagtct gtcacccggc     1440


<210> 36
<211> 480
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
145                 150                 155                 160 


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                165                 170                 175     


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ala Ala Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


<210> 37
<211> 1440
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
gacattcaga tgacacagag ccccagctcc ctgagtgctt cagtcggcga cagggtgact       60

atcacctgcc gcgcatccca ggatgtcaac accgctgtgg catggtacca gcagaagcct      120

ggaaaagccc caaagctgct gatctacagc gcttccttcc tgtattctgg cgtgccaagt      180

cggttttctg gaagtagatc aggcactgac ttcacactga ctatctctag tctgcagccc      240

gaagattttg ccacctacta ttgccagcag cactatacca caccccctac attcggatgc      300

ggcactaaag tggagattaa gggcgggtca ggcggaggga gcggaggagg gtccggagga      360

gggtctggag gagggagtgg agaggtccag ctggtggaat ctggaggagg actggtgcag      420

cctggaggct cactgcgact gagctgtgcc gcttccggct ttaacatcaa agacacatac      480

attcattggg tcaggcaggc accagggaag tgcctggaat gggtggcccg catctatccc      540

acaaatgggt acactcgata tgccgacagc gtgaaaggac ggtttaccat ttctgctgat      600

accagtaaga acacagcata cctgcagatg aacagcctgc gcgcagagga tacagccgtg      660

tactattgca gtcgatgggg gggagacggc ttctacgcca tggattattg gggccagggg      720

actctggtca ccgtgtcaag cgcagccgaa cctaaatcct ctgacaagac ccacacatgc      780

ccaccctgtc ctgctccaga gctgctggga ggaccatccg tgttcctgtt tcctccaaag      840

cctaaagata cactgatgat tagccgcact cccgaagtca cctgtgtggt cgtggacgtg      900

tcccacgagg accccgaagt caagttcaac tggtacgtgg acggcgtcga ggtgcataat      960

gccaagacta aaccaagaga ggaacagtac aattcaacct atagggtcgt gagcgtcctg     1020

acagtgctgc atcaggattg gctgaacggc aaggagtata agtgcaaagt gtctaacaag     1080

gccctgcccg ctcctatcga gaagactatt agcaaggcaa aagggcagcc acgggaaccc     1140

caggtctacg tgctgccccc tagcagagac gagctgacca aaaaccaggt ctccctgctg     1200

tgtctggtga agggctttta tcctagtgat atcgctgtgg agtgggaatc aaatgggcag     1260

ccagaaaaca attacctgac atggccaccc gtgctggaca gcgatgggtc cttctttctg     1320

tattccaaac tgactgtgga caagtctaga tggcagcagg gaaacgtctt cagctgttcc     1380

gtgatgcacg aggccctgca caatcattac acccagaagt ctctgagtct gtcacccggc     1440


<210> 38
<211> 480
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
145                 150                 155                 160 


Ile His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ala Ala Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


<210> 39
<211> 1443
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
caggtccagc tgcaggagag cggaggaggg ctggtcaaac ccggaggatc actgagactg       60

tcatgtgctg cttcaggatt cacttttagc tcctactgga tgtcttgggt gagacaggct      120

cctggcaagt gcctggagtg ggtggccaac atcaataggg acggctccgc ttcttactat      180

gtggatagcg tcaaggggag gttcactatt tcccgcgacg atgcaaaaaa ctctctgtac      240

ctgcagatga atagcctgcg cgccgaagac accgctgtgt actattgtgc ccgggacaga      300

ggagtcggct attttgatct gtgggggcga ggaactctgg tgaccgtctc tagtgccagc      360

accggaggag gaggctctgg aggaggaggg agtggaggcg ggggaagtca gtcagctctg      420

acccagccag caagcgtgtc cggatctccc ggccagagta tcacaatttc atgcaccggc      480

acatcaagcg atgtgggcgg gtacaacttc gtcagctggt atcagcagca ccccgggaag      540

gcacctaaac tgatgatcta cgacgtgtcc gatcgaccct ccggcgtctc tgaccggttt      600

agtgggtcaa agagcggaaa taccgccagc ctgatcattt ccggactgca ggcagacgat      660

gaggccgatt actattgctc ctcttatggc agttcaagca cacatgtgat tttcggctgt      720

gggactaaag tcaccgtgct gggagctgcc gaaccaaaaa gtagtgacaa aacccatacc      780

tgccccccct gcccggcgcc agaactgctg ggaggaccaa gcgtgttcct gtttccaccc      840

aagcctaaag acaccctgat gatttcccgg actcctgagg tcacctgcgt ggtcgtggac      900

gtgtctcacg aggaccccga agtcaagttc aactggtacg tggatggcgt cgaagtgcat      960

aatgccaaga ccaaaccccg ggaggaacag tacaactcta cctatagagt cgtgagtgtc     1020

ctgacagtgc tgcaccagga ctggctgaat gggaaggagt ataagtgtaa agtgagcaac     1080

aaagccctgc ccgccccaat cgaaaaaaca atctctaaag caaaaggaca gcctcgcgaa     1140

ccacaggtct acgtgctgcc ccctagccgc gacgaactga ctaaaaatca ggtctctctg     1200

ctgtgtctgg tcaaaggatt ctacccttcc gacatcgccg tggagtggga aagtaacggc     1260

cagcccgaga acaattacct gacctggccc cctgtgctgg actctgatgg gagtttcttt     1320

ctgtattcaa agctgacagt cgataaaagc cggtggcagc agggcaatgt gttcagctgc     1380

tccgtcatgc acgaagcact gcacaaccat tacactcaga agtccctgtc cctgtcacct     1440

ggc                                                                   1443


<210> 40
<211> 481
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly 
145                 150                 155                 160 


Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln 
                165                 170                 175     


His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg 
            180                 185                 190         


Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
        195                 200                 205             


Ala Ser Leu Ile Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ser Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Gly Ala Ala Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly 
    


<210> 41
<211> 1443
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
caggtccagc tgcaggagag cggaggaggg ctggtcaaac ccggaggatc actgagactg       60

tcatgtgctg cttcaggatt cacttttagc tcctactgga tgtcttgggt gagacaggct      120

cctggcaagt gcctggagtg ggtggccaac atcaataggg acggctccgc ttcttactat      180

gtggatagcg tcaaggggag gttcactatt tcccgcgacg atgcaaaaaa ctctctgtac      240

ctgcagatga atagcctgcg cgccgaagac accgctgtgt actattgtgc ccgggacaga      300

ggagtcggct attttgatct gtgggggcga ggaactctgg tgaccgtctc tagtgccagc      360

accggaggag gaggctctgg aggaggaggg agtggaggcg ggggaagtca gtcagctctg      420

acccagccag caagcgtgtc cggatctccc ggccagagta tcacaatttc atgcaccggc      480

acatcaagcg atgtgggcgg gtacaacttc gtcagctggt atcagcagca ccccgggaag      540

gcacctaaac tgatgatcta cgacgtgtcc gatcgaccct ccggcgtctc tgaccggttt      600

agtgggtcaa agagcggaaa taccgccagc ctgaccattt ccggactgca ggcagacgat      660

gaggccgatt actattgctc ctcttatggc agttcaagca cacatgtgat tttcggctgt      720

gggactaaag tcaccgtgct gggagctgcc gaaccaaaaa gtagtgacaa aacccatacc      780

tgccccccct gcccggcgcc agaactgctg ggaggaccaa gcgtgttcct gtttccaccc      840

aagcctaaag acaccctgat gatttcccgg actcctgagg tcacctgcgt ggtcgtggac      900

gtgtctcacg aggaccccga agtcaagttc aactggtacg tggatggcgt cgaagtgcat      960

aatgccaaga ccaaaccccg ggaggaacag tacaactcta cctatagagt cgtgagtgtc     1020

ctgacagtgc tgcaccagga ctggctgaat gggaaggagt ataagtgtaa agtgagcaac     1080

aaagccctgc ccgccccaat cgaaaaaaca atctctaaag caaaaggaca gcctcgcgaa     1140

ccacaggtct acgtgctgcc ccctagccgc gacgaactga ctaaaaatca ggtctctctg     1200

ctgtgtctgg tcaaaggatt ctacccttcc gacatcgccg tggagtggga aagtaacggc     1260

cagcccgaga acaattacct gacctggccc cctgtgctgg actctgatgg gagtttcttt     1320

ctgtattcaa agctgacagt cgataaaagc cggtggcagc agggcaatgt gttcagctgc     1380

tccgtcatgc acgaagcact gcacaaccat tacactcaga agtccctgtc cctgtcacct     1440

ggc                                                                   1443


<210> 42
<211> 481
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly 
145                 150                 155                 160 


Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln 
                165                 170                 175     


His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg 
            180                 185                 190         


Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
        195                 200                 205             


Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ser Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Gly Ala Ala Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly 
    


<210> 43
<211> 651
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 43
cagagcgcac tgactcagcc tgcttccgtg tccggctccc ctgggcagag tattacaatc       60

tcatgcactg gcacctcatc cgacgtgggc gggtacaact ttgtcagctg gtatcagcag      120

cacccaggca aggcccccaa actgatgatc tacgacgtgt ccgatcggcc ttccggggtc      180

tctgacagat tctccggatc taagagtggc aataccgcca gcctgatcat ttccgggctg      240

caggcagacg atgaggccga ttactattgc agctcctatg gatctagttc aacacatgtg      300

atcttcggag gcgggaccaa ggtgacagtc ctggggcagc ctaaagcggc gccctctgtg      360

actctgtttc cccctagctc cgaggaactg caggctaaca aggcaactct ggtgtgtctg      420

attagcgact tctacccagg agctgtgacc gtcgcctgga aggctgattc tagtcccgtg      480

aaagcaggcg tcgagaccac aactcctagt aagcagtcaa acaacaagta cgcagcctca      540

agctatctgt ctctgacacc cgaacagtgg aaaagtcaca ggtcatatag ctgccaggtg      600

actcacgagg gctcaactgt ggagaaaacc gtcgcaccaa ccgaatgttc c               651


<210> 44
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 
                85                  90                  95      


Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210> 45
<211> 654
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 45
cagagcgcac tgactcagcc tgcatccgtg tccgggtccc ctgggcagag cattactatt       60

tcatgtactg gaacttcttc agacgtgggc gggtacaact tcgtgtcctg gtatcagcag      120

caccccggca aggcacctaa actgatgatc tacgacgtga gcgatcgacc aagcggggtc      180

tccgacagat tttctggaag taaatcaggc aataccgcct ctctgatcat tagtgggctg      240

caggccgacg atgaggctga ttactattgc agctcctatg gatctagtag cacccatgtc      300

attttcggag gcggaacaaa ggtcaccgtc ctgagaaccg tggcggcgcc cagtgtcttc      360

atttttcccc ctagcgacga acagctgaag tctgggacag ccagtgtggt ctgtctgctg      420

aacaacttct accctcgcga ggctaaagtg cagtggaagg tcgataacgc actgcagtcc      480

ggaaattctc aggagagtgt gactgaacag gactcaaaag atagcaccta ttccctgtca      540

agcacactga ctctgagcaa ggccgactac gagaagcata aagtgtatgc ttgtgaagtc      600

acccaccagg ggctgagttc accagtcaca aaatcattca acagagggga gtgc            654


<210> 46
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 
                85                  90                  95      


Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210> 47
<211> 1341
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 47
caggtccagc tgcaggaatc tggcggagga ctggtcaaac ctggaggctc tctgagactg       60

tcatgtgctg ctagtggctt tactttcagc tcctactgga tgtcttgggt gcgacaggcc      120

cccggcaagg gactggagtg ggtcgcaaac atcaatagag acggatctgc cagttactat      180

gtggatagcg tcaagggccg gttcaccatt tcaagagacg atgctaaaaa cagcctgtat      240

ctgcagatga acagcctgag ggccgaagac acagctgtgt actattgcgc acgcgatcgc      300

ggcgtgggat atttcgatct gtggggccgc ggaaccctgg tgaccgtctc atctgctagc      360

actaaggggc cttccgtgtt tccactggct ccctctagta aatccacctc tggaggcaca      420

gctgcactgg gatgtctggt gaaggattac ttccctgaac cagtcacagt gagttggaac      480

tcaggggctc tgacaagtgg agtccatact tttcccgcag tgctgcagtc aagcggactg      540

tactccctgt cctctgtggt caccgtgcct agttcaagcc tgggcaccca gacatatatc      600

tgcaacgtga atcacaagcc atcaaataca aaagtcgaca agaaagtgga gcccaagagc      660

tgtgataaaa ctcatacctg cccaccttgt ccggcgccag aactgctggg aggaccaagc      720

gtgttcctgt ttccacccaa gcctaaagac accctgatga tttcccggac tcctgaggtc      780

acctgcgtgg tcgtggacgt gtctcacgag gaccccgaag tcaagttcaa ctggtacgtg      840

gatggcgtcg aagtgcataa tgccaagacc aaaccccggg aggaacagta caactctacc      900

tatagagtcg tgagtgtcct gacagtgctg caccaggact ggctgaatgg gaaggagtat      960

aagtgtaaag tgagcaacaa agccctgccc gccccaatcg aaaaaacaat ctctaaagca     1020

aaaggacagc ctcgcgaacc acaggtctac gtctaccccc catcaagaga tgaactgaca     1080

aaaaatcagg tctctctgac atgcctggtc aaaggattct acccttccga catcgccgtg     1140

gagtgggaaa gtaacggcca gcccgagaac aattacaaga ccacaccccc tgtcctggac     1200

tctgatggga gtttcgctct ggtgtcaaag ctgaccgtcg ataaaagccg gtggcagcag     1260

ggcaatgtgt ttagctgctc cgtcatgcac gaagccctgc acaatcacta cacacagaag     1320

tccctgagcc tgagccctgg c                                               1341


<210> 48
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Tyr 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Gly Phe Asn Ile Lys Asp Thr 
1               5           


<210> 50
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Tyr Pro Thr Asn Gly 
1               5   


<210> 51
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210> 52
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210> 55
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 56
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 57
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 58
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Ile Asn Arg Asp Gly Ser Ala Ser 
1               5               


<210> 60
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu 
1               5                   10      


<210> 61
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 
                85                  90                  95      


Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 62
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Ser Ser Asp Val Gly Gly Tyr Asn Phe 
1               5                   


<210> 63
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Ser Ser Tyr Gly Ser Ser Ser Thr His Val Ile 
1               5                   10      


<210> 64
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Ser Tyr Trp Met Ser 
1               5   


<210> 65
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 66
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Asp Arg Gly Val Gly Tyr Phe Asp Leu 
1               5                   


<210> 67
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser 
1               5                   10                  


<210> 68
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Asp Val Ser Asp Arg Pro Ser 
1               5           


<210> 69
<211> 217
<212> PRT
<213> Homo sapiens

<400> 69
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


