                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> A METHOD OF PREVENTING AND TREATING TYPE 1 DIABETES, ALLOGRAFT 
      REJECTION AND LUNG FIBROSIS (BY TARGETING THE ATP/P2X7R AXIS)

<130> 701039-077061-PCT

<140>
<141>

<150> 61/820,763
<151> 2013-05-08

<160> 4     

<170> PatentIn version 3.5

<210> 1
<211> 595
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Ala Cys Cys Ser Cys Ser Asp Val Phe Gln Tyr Glu Thr Asn 
1               5                   10                  15      


Lys Val Thr Arg Ile Gln Ser Met Asn Tyr Gly Thr Ile Lys Trp Phe 
            20                  25                  30          


Phe His Val Ile Ile Phe Ser Tyr Val Cys Phe Ala Leu Val Ser Asp 
        35                  40                  45              


Lys Leu Tyr Gln Arg Lys Glu Pro Val Ile Ser Ser Val His Thr Lys 
    50                  55                  60                  


Val Lys Gly Ile Ala Glu Val Lys Glu Glu Ile Val Glu Asn Gly Val 
65                  70                  75                  80  


Lys Lys Leu Val His Ser Val Phe Asp Thr Ala Asp Tyr Thr Phe Pro 
                85                  90                  95      


Leu Gln Gly Asn Ser Phe Phe Val Met Thr Asn Phe Leu Lys Thr Glu 
            100                 105                 110         


Gly Gln Glu Gln Arg Leu Cys Pro Glu Tyr Pro Thr Arg Arg Thr Leu 
        115                 120                 125             


Cys Ser Ser Asp Arg Gly Cys Lys Lys Gly Trp Met Asp Pro Gln Ser 
    130                 135                 140                 


Lys Gly Ile Gln Thr Gly Arg Cys Val Val Tyr Glu Gly Asn Gln Lys 
145                 150                 155                 160 


Thr Cys Glu Val Ser Ala Trp Cys Pro Ile Glu Ala Val Glu Glu Ala 
                165                 170                 175     


Pro Arg Pro Ala Leu Leu Asn Ser Ala Glu Asn Phe Thr Val Leu Ile 
            180                 185                 190         


Lys Asn Asn Ile Asp Phe Pro Gly His Asn Tyr Thr Thr Arg Asn Ile 
        195                 200                 205             


Leu Pro Gly Leu Asn Ile Thr Cys Thr Phe His Lys Thr Gln Asn Pro 
    210                 215                 220                 


Gln Cys Pro Ile Phe Arg Leu Gly Asp Ile Phe Arg Glu Thr Gly Asp 
225                 230                 235                 240 


Asn Phe Ser Asp Val Ala Ile Gln Gly Gly Ile Met Gly Ile Glu Ile 
                245                 250                 255     


Tyr Trp Asp Cys Asn Leu Asp Arg Trp Phe His His Cys Arg Pro Lys 
            260                 265                 270         


Tyr Ser Phe Arg Arg Leu Asp Asp Lys Thr Thr Asn Val Ser Leu Tyr 
        275                 280                 285             


Pro Gly Tyr Asn Phe Arg Tyr Ala Lys Tyr Tyr Lys Glu Asn Asn Val 
    290                 295                 300                 


Glu Lys Arg Thr Leu Ile Lys Val Phe Gly Ile Arg Phe Asp Ile Leu 
305                 310                 315                 320 


Val Phe Gly Thr Gly Gly Lys Phe Asp Ile Ile Gln Leu Val Val Tyr 
                325                 330                 335     


Ile Gly Ser Thr Leu Ser Tyr Phe Gly Leu Ala Ala Val Phe Ile Asp 
            340                 345                 350         


Phe Leu Ile Asp Thr Tyr Ser Ser Asn Cys Cys Arg Ser His Ile Tyr 
        355                 360                 365             


Pro Trp Cys Lys Cys Cys Gln Pro Cys Val Val Asn Glu Tyr Tyr Tyr 
    370                 375                 380                 


Arg Lys Lys Cys Glu Ser Ile Val Glu Pro Lys Pro Thr Leu Lys Tyr 
385                 390                 395                 400 


Val Ser Phe Val Asp Glu Ser His Ile Arg Met Val Asn Gln Gln Leu 
                405                 410                 415     


Leu Gly Arg Ser Leu Gln Asp Val Lys Gly Gln Glu Val Pro Arg Pro 
            420                 425                 430         


Ala Met Asp Phe Thr Asp Leu Ser Arg Leu Pro Leu Ala Leu His Asp 
        435                 440                 445             


Thr Pro Pro Ile Pro Gly Gln Pro Glu Glu Ile Gln Leu Leu Arg Lys 
    450                 455                 460                 


Glu Ala Thr Pro Arg Ser Arg Asp Ser Pro Val Trp Cys Gln Cys Gly 
465                 470                 475                 480 


Ser Cys Leu Pro Ser Gln Leu Pro Glu Ser His Arg Cys Leu Glu Glu 
                485                 490                 495     


Leu Cys Cys Arg Lys Lys Pro Gly Ala Cys Ile Thr Thr Ser Glu Leu 
            500                 505                 510         


Phe Arg Lys Leu Val Leu Ser Arg His Val Leu Gln Phe Leu Leu Leu 
        515                 520                 525             


Tyr Gln Glu Pro Leu Leu Ala Leu Asp Val Asp Ser Thr Asn Ser Arg 
    530                 535                 540                 


Leu Arg His Cys Ala Tyr Arg Cys Tyr Ala Thr Trp Arg Phe Gly Ser 
545                 550                 555                 560 


Gln Asp Met Ala Asp Phe Ala Ile Leu Pro Ser Cys Cys Arg Trp Arg 
                565                 570                 575     


Ile Arg Lys Glu Phe Pro Lys Ser Glu Gly Gln Tyr Ser Gly Phe Lys 
            580                 585                 590         


Ser Pro Tyr 
        595 


<210> 2
<211> 290
<212> PRT
<213> Homo sapiens

<400> 2
Ser Asp Lys Leu Tyr Gln Arg Lys Glu Pro Val Ile Ser Ser Val His 
1               5                   10                  15      


Thr Lys Val Lys Gly Ile Ala Glu Val Lys Glu Glu Ile Val Glu Asn 
            20                  25                  30          


Gly Val Lys Lys Leu Val His Ser Val Phe Asp Thr Ala Asp Tyr Thr 
        35                  40                  45              


Phe Pro Leu Gln Gly Asn Ser Phe Phe Val Met Thr Asn Phe Leu Lys 
    50                  55                  60                  


Thr Glu Gly Gln Glu Gln Arg Leu Cys Pro Glu Tyr Pro Thr Arg Arg 
65                  70                  75                  80  


Thr Leu Cys Ser Ser Asp Arg Gly Cys Lys Lys Gly Trp Met Asp Pro 
                85                  90                  95      


Gln Ser Lys Gly Ile Gln Thr Gly Arg Cys Val Val Tyr Glu Gly Asn 
            100                 105                 110         


Gln Lys Thr Cys Glu Val Ser Ala Trp Cys Pro Ile Glu Ala Val Glu 
        115                 120                 125             


Glu Ala Pro Arg Pro Ala Leu Leu Asn Ser Ala Glu Asn Phe Thr Val 
    130                 135                 140                 


Leu Ile Lys Asn Asn Ile Asp Phe Pro Gly His Asn Tyr Thr Thr Arg 
145                 150                 155                 160 


Asn Ile Leu Pro Gly Leu Asn Ile Thr Cys Thr Phe His Lys Thr Gln 
                165                 170                 175     


Asn Pro Gln Cys Pro Ile Phe Arg Leu Gly Asp Ile Phe Arg Glu Thr 
            180                 185                 190         


Gly Asp Asn Phe Ser Asp Val Ala Ile Gln Gly Gly Ile Met Gly Ile 
        195                 200                 205             


Glu Ile Tyr Trp Asp Cys Asn Leu Asp Arg Trp Phe His His Cys Arg 
    210                 215                 220                 


Pro Lys Tyr Ser Phe Arg Arg Leu Asp Asp Lys Thr Thr Asn Val Ser 
225                 230                 235                 240 


Leu Tyr Pro Gly Tyr Asn Phe Arg Tyr Ala Lys Tyr Tyr Lys Glu Asn 
                245                 250                 255     


Asn Val Glu Lys Arg Thr Leu Ile Lys Val Phe Gly Ile Arg Phe Asp 
            260                 265                 270         


Ile Leu Val Phe Gly Thr Gly Gly Lys Phe Asp Ile Ile Gln Leu Val 
        275                 280                 285             


Val Tyr 
    290 


<210> 3
<211> 3680
<212> DNA
<213> Homo sapiens

<400> 3
gtcattggag gagcttgaag ttaaagactc ctgctaaaaa ccagtacgtt tcattttgca       60

gttactggga gggggcttgc tgtggccctg tcaggaagag tagagctctg gtccagctcc      120

gcgcagggag ggaggctgtc accatgccgg cctgctgcag ctgcagtgat gttttccagt      180

atgagacgaa caaagtcact cggatccaga gcatgaatta tggcaccatt aagtggttct      240

tccacgtgat catcttttcc tacgtttgct ttgctctggt gagtgacaag ctgtaccagc      300

ggaaagagcc tgtcatcagt tctgtgcaca ccaaggtgaa ggggatagca gaggtgaaag      360

aggagatcgt ggagaatgga gtgaagaagt tggtgcacag tgtctttgac accgcagact      420

acaccttccc tttgcagggg aactctttct tcgtgatgac aaactttctc aaaacagaag      480

gccaagagca gcggttgtgt cccgagtatc ccacccgcag gacgctctgt tcctctgacc      540

gaggttgtaa aaagggatgg atggacccgc agagcaaagg aattcagacc ggaaggtgtg      600

tagtgtatga agggaaccag aagacctgtg aagtctctgc ctggtgcccc atcgaggcag      660

tggaagaggc cccccggcct gctctcttga acagtgccga aaacttcact gtgctcatca      720

agaacaatat cgacttcccc ggccacaact acaccacgag aaacatcctg ccaggtttaa      780

acatcacttg taccttccac aagactcaga atccacagtg tcccattttc cgactaggag      840

acatcttccg agaaacaggc gataattttt cagatgtggc aattcagggc ggaataatgg      900

gcattgagat ctactgggac tgcaacctag accgttggtt ccatcactgc cgtcccaaat      960

acagtttccg tcgccttgac gacaagacca ccaacgtgtc cttgtaccct ggctacaact     1020

tcagatacgc caagtactac aaggaaaaca atgttgagaa acggactctg ataaaagtct     1080

tcgggatccg ttttgacatc ctggtttttg gcaccggagg aaaatttgac attatccagc     1140

tggttgtgta catcggctca accctctcct acttcggtct ggccgctgtg ttcatcgact     1200

tcctcatcga cacttactcc agtaactgct gtcgctccca tatttatccc tggtgcaagt     1260

gctgtcagcc ctgtgtggtc aacgaatact actacaggaa gaagtgcgag tccattgtgg     1320

agccaaagcc gacattaaag tatgtgtcct ttgtggatga atcccacatt aggatggtga     1380

accagcagct actagggaga agtctgcaag atgtcaaggg ccaagaagtc ccaagacctg     1440

cgatggactt cacagatttg tccaggctgc ccctggccct ccatgacaca cccccgattc     1500

ctggacaacc agaggagata cagctgctta gaaaggaggc gactcctaga tccagggata     1560

gccccgtctg gtgccagtgt ggaagctgcc tcccatctca actccctgag agccacaggt     1620

gcctggagga gctgtgctgc cggaaaaagc cgggggcctg catcaccacc tcagagctgt     1680

tcaggaagct ggtcctgtcc agacacgtcc tgcagttcct cctgctctac caggagccct     1740

tgctggcgct ggatgtggat tccaccaaca gccggctgcg gcactgtgcc tacaggtgct     1800

acgccacctg gcgcttcggc tcccaggaca tggctgactt tgccatcctg cccagctgct     1860

gccgctggag gatccggaaa gagtttccga agagtgaagg gcagtacagt ggcttcaaga     1920

gtccttactg aagccaggca ccgtggctca cgtctgtaat cccagcgctt tgggaggccg     1980

aggcaggcag atcacctgag gtcgggagtt ggagacccgc ctggctaaca aggcgaaatc     2040

ctgtctgtac taaaaataca aaaatcagcc agacatggtg gcatgcacct gcaatcccag     2100

ctactcggga ggctgaggca caagaatcac ttgaacccgg gaggcagagg ttgtagtgag     2160

cccagattgt gccactgctc tccagcctgg gaggcacagc aaactgtccc ccaaaaaaaa     2220

aaaagagtcc ttaccaatag caggggctgc agtagccatg ttaacatgac atttaccagc     2280

aacttgaact tcacctgcaa agctctgtgg ccacattttc agccaaaggg aaatatgctt     2340

tcatcttctg ttgctctctg tgtctgagag caaagtgacc tggttaaaca aaccagaatc     2400

cctctacatg gactcagaga aaagagattg agatgtaagt ctcaactctg tccccaggaa     2460

gttgtgtgac cctaggcctc tcacctctgt gcctctgtct ccttgttgcc caactactat     2520

ctcagagata ttgtgaggac aaattgagac agtgcacatg aactgtcttt taatgtgtaa     2580

agatctacat gaatgcaaaa catttcatta tgaggtcaga ctaggataat gtccaactaa     2640

aaacaaaccc ttttcatcct ggctggagaa tgtggagaac taaaggtggc cacaaattct     2700

ttgacactca agtcccccaa gacctaaggg ttttatctcc tccccttgaa tatgggtggc     2760

tctgattgct ttatccaaaa gtggaagtga cattgtgtca gtttcagatc ctgatcttaa     2820

gaggctgaca gcttctactt gctgtccctt ggaactcttg ctatcgggga agccagacgc     2880

catttaaaag tctgcctatc ctggccaggt gtggtggctc acacctgtaa tcccagcact     2940

ttgggagacc aaggcgggcg gatcacttaa agtcaggagt ccaagaccag actcgccaac     3000

atggtgaaac cgtatctcta ataaaaatac aaaaattagc tgggcatggt gcgggcacct     3060

gtagtcctag ctatcaagag gctgagacag gagaaacact tgaacctggg aggtggaggt     3120

tgcattgagc tgagatcgtg ccactgcact ccaggctggg tgacagagcg agactccatc     3180

tcaaaaaaaa aaaaaagaaa aaaaaaatgt ctgcctatcc tgagactgcc ctgctgtgag     3240

gaagcccaag cagtcacgtg gacagtgcct gaccagcccc agctttcaag ccatccaagc     3300

ccagtcacca aacatgagag agaagaagcc ttcaggtgat tctggactcc actaacatat     3360

gactgatacc gcatgataca tcccaagtga gaactgcccc ataaatccag aaaaccacat     3420

tgctatctta agtccctaag tttggggctt atttgttcca cagcaacagg taactggaac     3480

agagggcaag cctgatgaat gggcacacag actcagccca taccttccct ggttctaatg     3540

ttctcaggga gcccggacca accctgggag cctcaggaac ttaggtttcc actggacagt     3600

tctagaaggg ctatagacca aatcaggtaa ctcaccagac cagccttgga atctatcaaa     3660

tctaactgct gagctaccca                                                 3680


<210> 4
<211> 595
<212> PRT
<213> Homo sapiens

<400> 4
Met Pro Ala Cys Cys Ser Cys Ser Asp Val Phe Gln Tyr Glu Thr Asn 
1               5                   10                  15      


Lys Val Thr Arg Ile Gln Ser Met Asn Tyr Gly Thr Ile Lys Trp Phe 
            20                  25                  30          


Phe His Val Ile Ile Phe Ser Tyr Val Cys Phe Ala Leu Val Ser Asp 
        35                  40                  45              


Lys Leu Tyr Gln Arg Lys Glu Pro Val Ile Ser Ser Val His Thr Lys 
    50                  55                  60                  


Val Lys Gly Ile Ala Glu Val Lys Glu Glu Ile Val Glu Asn Gly Val 
65                  70                  75                  80  


Lys Lys Leu Val His Ser Val Phe Asp Thr Ala Asp Tyr Thr Phe Pro 
                85                  90                  95      


Leu Gln Gly Asn Ser Phe Phe Val Met Thr Asn Phe Leu Lys Thr Glu 
            100                 105                 110         


Gly Gln Glu Gln Arg Leu Cys Pro Glu Tyr Pro Thr Arg Arg Thr Leu 
        115                 120                 125             


Cys Ser Ser Asp Arg Gly Cys Lys Lys Gly Trp Met Asp Pro Gln Ser 
    130                 135                 140                 


Lys Gly Ile Gln Thr Gly Arg Cys Val Val Tyr Glu Gly Asn Gln Lys 
145                 150                 155                 160 


Thr Cys Glu Val Ser Ala Trp Cys Pro Ile Glu Ala Val Glu Glu Ala 
                165                 170                 175     


Pro Arg Pro Ala Leu Leu Asn Ser Ala Glu Asn Phe Thr Val Leu Ile 
            180                 185                 190         


Lys Asn Asn Ile Asp Phe Pro Gly His Asn Tyr Thr Thr Arg Asn Ile 
        195                 200                 205             


Leu Pro Gly Leu Asn Ile Thr Cys Thr Phe His Lys Thr Gln Asn Pro 
    210                 215                 220                 


Gln Cys Pro Ile Phe Arg Leu Gly Asp Ile Phe Arg Glu Thr Gly Asp 
225                 230                 235                 240 


Asn Phe Ser Asp Val Ala Ile Gln Gly Gly Ile Met Gly Ile Glu Ile 
                245                 250                 255     


Tyr Trp Asp Cys Asn Leu Asp Arg Trp Phe His His Cys Arg Pro Lys 
            260                 265                 270         


Tyr Ser Phe Arg Arg Leu Asp Asp Lys Thr Thr Asn Val Ser Leu Tyr 
        275                 280                 285             


Pro Gly Tyr Asn Phe Arg Tyr Ala Lys Tyr Tyr Lys Glu Asn Asn Val 
    290                 295                 300                 


Glu Lys Arg Thr Leu Ile Lys Val Phe Gly Ile Arg Phe Asp Ile Leu 
305                 310                 315                 320 


Val Phe Gly Thr Gly Gly Lys Phe Asp Ile Ile Gln Leu Val Val Tyr 
                325                 330                 335     


Ile Gly Ser Thr Leu Ser Tyr Phe Gly Leu Ala Ala Val Phe Ile Asp 
            340                 345                 350         


Phe Leu Ile Asp Thr Tyr Ser Ser Asn Cys Cys Arg Ser His Ile Tyr 
        355                 360                 365             


Pro Trp Cys Lys Cys Cys Gln Pro Cys Val Val Asn Glu Tyr Tyr Tyr 
    370                 375                 380                 


Arg Lys Lys Cys Glu Ser Ile Val Glu Pro Lys Pro Thr Leu Lys Tyr 
385                 390                 395                 400 


Val Ser Phe Val Asp Glu Ser His Ile Arg Met Val Asn Gln Gln Leu 
                405                 410                 415     


Leu Gly Arg Ser Leu Gln Asp Val Lys Gly Gln Glu Val Pro Arg Pro 
            420                 425                 430         


Ala Met Asp Phe Thr Asp Leu Ser Arg Leu Pro Leu Ala Leu His Asp 
        435                 440                 445             


Thr Pro Pro Ile Pro Gly Gln Pro Glu Glu Ile Gln Leu Leu Arg Lys 
    450                 455                 460                 


Glu Ala Thr Pro Arg Ser Arg Asp Ser Pro Val Trp Cys Gln Cys Gly 
465                 470                 475                 480 


Ser Cys Leu Pro Ser Gln Leu Pro Glu Ser His Arg Cys Leu Glu Glu 
                485                 490                 495     


Leu Cys Cys Arg Lys Lys Pro Gly Ala Cys Ile Thr Thr Ser Glu Leu 
            500                 505                 510         


Phe Arg Lys Leu Val Leu Ser Arg His Val Leu Gln Phe Leu Leu Leu 
        515                 520                 525             


Tyr Gln Glu Pro Leu Leu Ala Leu Asp Val Asp Ser Thr Asn Ser Arg 
    530                 535                 540                 


Leu Arg His Cys Ala Tyr Arg Cys Tyr Ala Thr Trp Arg Phe Gly Ser 
545                 550                 555                 560 


Gln Asp Met Ala Asp Phe Ala Ile Leu Pro Ser Cys Cys Arg Trp Arg 
                565                 570                 575     


Ile Arg Lys Glu Phe Pro Lys Ser Glu Gly Gln Tyr Ser Gly Phe Lys 
            580                 585                 590         


Ser Pro Tyr 
        595 


