SEQUENCE LISTING

<110>   NOVARTIS AG
        Lawrence STEINMAN
        Wayne VOLKMUTH

<120>   AVOIDING NARCOLEPSY RISK IN INFLUENZA VACCINES

<130>   P063804WO

<140>   PCT/EP2014/______
<141>   2014-05-09

<150>   US 61/822,228
<151>   2013-05-10

<150>   US 61/859,113
<151>   2013-07-26

<150>   US 61/862,807
<151>   2013-08-06

<150>   EP-13181429.5
<151>   2013-08-23

<150>   EP-14158999.4
<151>   2014-03-11

<160>   33

<170>   SeqWin2010, version 1.0

<210>   1
<211>   21
<212>   PRT
<213>   Influenza A virus

<400>   1
Arg Glu Leu Ile Leu Tyr Asp Lys Glu Glu Ile Arg Arg Ile Trp Arg 
1               5                   10                  15      

Gln Ala Asn Asn Gly 
            20      

<210>   2
<211>   498
<212>   PRT
<213>   Influenza A virus

<400>   2
Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      

Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          

Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              

Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  

Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  

Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      

Tyr Arg Arg Val Asn Gly Lys Trp Met Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         

Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             

Ala Ala Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 

Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 

Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     

Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         

Leu Val Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             

Gly Glu Asn Gly Arg Lys Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 

Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Lys Ala Met Met Asp 
225                 230                 235                 240 

Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Phe Glu Asp Leu 
                245                 250                 255     

Thr Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         

Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             

Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 

Arg Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 

Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     

Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Lys Gly Thr Lys Val 
            340                 345                 350         

Leu Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             

Glu Asn Met Glu Thr Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 

Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 

Ala Ser Ala Gly Gln Ile Ser Ile Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     

Asn Leu Pro Phe Asp Arg Thr Thr Ile Met Ala Ala Phe Asn Gly Asn 
            420                 425                 430         

Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             

Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 

Glu Leu Ser Asp Glu Lys Ala Ala Ser Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 

Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     

Asp Asn 
        

<210>   3
<211>   21
<212>   PRT
<213>   Influenza A virus

<400>   3
Arg Glu Leu Ile Leu Tyr Asp Lys Glu Glu Met Arg Arg Ile Trp Arg 
1               5                   10                  15      

Gln Ala Asn Asn Gly 
            20      

<210>   4
<211>   21
<212>   PRT
<213>   Influenza A virus

<400>   4
Trp Arg Gln Ala Asn Asn Gly Asp Asp Ala Ala Ala Gly Leu Thr His 
1               5                   10                  15      

Met Met Ile Trp His 
            20      

<210>   5
<211>   21
<212>   PRT
<213>   Influenza A virus

<400>   5
Trp Arg Gln Ala Asn Asn Gly Asp Asp Ala Thr Ala Gly Leu Thr His 
1               5                   10                  15      

Met Met Ile Trp His 
            20      

<210>   6
<211>   21
<212>   PRT
<213>   Influenza A virus

<400>   6
Lys Thr Ser Ser Trp Pro Asn His Asp Ser Asn Lys Gly Val Thr Ala 
1               5                   10                  15      

Ala Cys Pro His Ala 
            20      

<210>   7
<211>   21
<212>   PRT
<213>   Influenza A virus

<400>   7
Lys Thr Ser Ser Trp Pro Asn His Asp Ser Asp Lys Gly Val Thr Ala 
1               5                   10                  15      

Ala Cys Pro His Ala 
            20      

<210>   8
<211>   9
<212>   PRT
<213>   Influenza A virus

<400>   8
Leu Ile Leu Tyr Asp Lys Glu Glu Ile 
1               5                   

<210>   9
<211>   14
<212>   PRT
<213>   Influenza A virus

<220>
<221>   misc_feature
<222>   2, 5, 6, 7, 9, 10, 11, 12, 13, 14
<223>   'Xaa' is any amino acid

<400>   9
Leu Xaa Leu Tyr Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  

<210>   10
<211>   19
<212>   PRT
<213>   Influenza A virus

<400>   10
Leu Ile Leu Tyr Asp Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala 
1               5                   10                  15      

Asn Asn Gly 
            

<210>   11
<211>   9
<212>   PRT
<213>   Influenza A virus

<220>
<221>   misc_feature
<222>   9
<223>   'Xaa' is any amino acid

<400>   11
Leu Ile Leu Tyr Asp Lys Glu Glu Xaa 
1               5                   

<210>   12
<211>   498
<212>   PRT
<213>   Influenza A virus

<400>   12
Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      

Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          

Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              

Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  

Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  

Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      

Tyr Arg Arg Val Asn Gly Lys Trp Met Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         

Lys Glu Glu Met Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             

Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 

Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 

Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     

Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         

Leu Val Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             

Gly Glu Asn Gly Arg Lys Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 

Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Lys Ala Met Met Asp 
225                 230                 235                 240 

Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Phe Glu Asp Leu 
                245                 250                 255     

Thr Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         

Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             

Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 

Arg Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 

Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     

Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Lys Gly Thr Lys Val 
            340                 345                 350         

Leu Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             

Glu Asn Met Glu Thr Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 

Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 

Ala Ser Ala Gly Gln Ile Ser Ile Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     

Asn Leu Pro Phe Asp Arg Thr Thr Ile Met Ala Ala Phe Asn Gly Asn 
            420                 425                 430         

Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             

Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 

Glu Leu Ser Asp Glu Lys Ala Ala Ser Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 

Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     

Asp Asn 
        

<210>   13
<211>   498
<212>   PRT
<213>   Influenza A virus

<400>   13
Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      

Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          

Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              

Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  

Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  

Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      

Tyr Arg Arg Val Asn Gly Lys Trp Met Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         

Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             

Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 

Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 

Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     

Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         

Leu Val Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             

Gly Glu Asn Gly Arg Lys Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 

Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Lys Ala Met Met Asp 
225                 230                 235                 240 

Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Phe Glu Asp Leu 
                245                 250                 255     

Thr Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         

Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             

Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 

Arg Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 

Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     

Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Lys Gly Thr Lys Val 
            340                 345                 350         

Leu Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             

Glu Asn Met Glu Thr Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 

Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 

Ala Ser Ala Gly Gln Ile Ser Ile Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     

Asn Leu Pro Phe Asp Arg Thr Thr Ile Met Ala Ala Phe Asn Gly Asn 
            420                 425                 430         

Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             

Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 

Glu Leu Ser Asp Glu Lys Ala Ala Ser Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 

Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     

Asp Asn 
        

<210>   14
<211>   120
<212>   PRT
<213>   Homo sapiens

<400>   14
Thr Lys Leu Glu Asp Ser Pro Pro Cys Arg Asn Trp Ser Ser Ala Ser 
1               5                   10                  15      

Glu Leu Asn Glu Thr Gln Glu Pro Phe Leu Asn Pro Thr Asp Tyr Asp 
            20                  25                  30          

Asp Glu Glu Phe Leu Arg Tyr Leu Trp Arg Glu Tyr Leu His Pro Lys 
        35                  40                  45              

Glu Tyr Glu Trp Val Leu Ile Ala Gly Tyr Ile Ile Val Phe Val Val 
    50                  55                  60                  

Ala Leu Ile Gly Asn Val Leu Val Cys Val Ala Val Trp Lys Asn His 
65                  70                  75                  80  

His Met Arg Thr Val Thr Asn Tyr Phe Ile Val Asn Leu Ser Leu Ala 
                85                  90                  95      

Asp Val Leu Val Thr Ile Thr Cys Leu Pro Ala Thr Leu Val Val Asp 
            100                 105                 110         

Ile Thr Glu Thr Trp Phe Phe Gly 
        115                 120 

<210>   15
<211>   120
<212>   PRT
<213>   Homo sapiens

<400>   15
Met Glu Pro Ser Ala Thr Pro Gly Ala Gln Met Gly Val Pro Pro Gly 
1               5                   10                  15      

Ser Arg Glu Pro Ser Pro Val Pro Pro Asp Tyr Glu Asp Glu Phe Leu 
            20                  25                  30          

Arg Tyr Leu Trp Arg Asp Tyr Leu Tyr Pro Lys Gln Tyr Glu Trp Val 
        35                  40                  45              

Leu Ile Ala Ala Tyr Val Ala Val Phe Val Val Ala Leu Val Gly Asn 
    50                  55                  60                  

Thr Leu Val Cys Leu Ala Val Trp Arg Asn His His Met Arg Thr Val 
65                  70                  75                  80  

Thr Asn Tyr Phe Ile Val Asn Leu Ser Leu Ala Asp Val Leu Val Thr 
                85                  90                  95      

Ala Ile Cys Leu Pro Ala Ser Leu Leu Val Asp Ile Thr Glu Ser Trp 
            100                 105                 110         

Leu Phe Gly His Ala Leu Cys Lys 
        115                 120 

<210>   16
<211>   13
<212>   PRT
<213>   Homo sapiens

<400>   16
Met Asn Leu Pro Ser Thr Lys Val Ser Trp Ala Ala Val 
1               5                   10              

<210>   17
<211>   12
<212>   PRT
<213>   Influenza A virus

<400>   17
Tyr Asp Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln 
1               5                   10          

<210>   18
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   18
Leu Ile Leu Tyr Asp Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln 
1               5                   10                  15  

<210>   19
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   19
Leu Ile Leu Tyr Asp Lys Glu Glu Met Arg Arg Ile Trp Arg Gln 
1               5                   10                  15  

<210>   20
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   20
Val Gly Lys Met Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met 
1               5                   10                  15  

<210>   21
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   21
Ser Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val 
1               5                   10                  15  

<210>   22
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   22
Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp Met Ser Asn 
1               5                   10                  15  

<210>   23
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   23
Ile Asp Pro Phe Lys Leu Leu Gln Asn Ser Gln Val Val Ser Leu 
1               5                   10                  15  

<210>   24
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   24
Leu Ile Leu Tyr Asp Lys Glu Glu Arg Arg Arg Arg Trp Arg Gln 
1               5                   10                  15  

<210>   25
<211>   15
<212>   PRT
<213>   Homo sapiens

<400>   25
Met Asn Leu Pro Ser Thr Lys Val Ser Trp Ala Ala Val Thr Leu 
1               5                   10                  15  

<210>   26
<211>   15
<212>   PRT
<213>   Homo sapiens

<400>   26
Met Asn Leu Pro Ser Ile Lys Val Ser Trp Ala Ala Val Thr Leu 
1               5                   10                  15  

<210>   27
<211>   15
<212>   PRT
<213>   Homo sapiens

<400>   27
Met Asn Leu Pro Ser Met Lys Val Ser Trp Ala Ala Val Thr Leu 
1               5                   10                  15  

<210>   28
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   28
Leu Thr Val Ala Ala Trp Ser Val Lys Thr Ser Pro Leu Asn Met 
1               5                   10                  15  

<210>   29
<211>   15
<212>   PRT
<213>   Homo sapiens

<400>   29
Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr Leu Gly Lys Arg 
1               5                   10                  15  

<210>   30
<211>   15
<212>   PRT
<213>   Homo sapiens

<400>   30
Ala Ser Gly Asn His Ala Ala Gly Ile Leu Thr Met Gly Arg Arg 
1               5                   10                  15  

<210>   31
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   31
Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr 
1               5                   10                  15  

<210>   32
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   32
Ala Leu Asn Arg Gly Ser Gly Ser Gly Ile Ile Thr Ser Asp Ala 
1               5                   10                  15  

<210>   33
<211>   15
<212>   PRT
<213>   Influenza A virus

<400>   33
Ala Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala 
1               5                   10                  15  

