                         SEQUENCE LISTING

<110>  Katholieke Universiteit Leuven, KU Leuven R&D
 
<120>  INHIBITOR OF CALCIFYING DISORDERS

<130>  LRD-026

<150>  GB1308117.9
<151>  2013-05-06

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  446
<212>  PRT
<213>  Human

<400>  1

Met Leu Leu Pro Gln Leu Cys Trp Leu Pro Leu Leu Ala Gly Leu Leu 
1               5                   10                  15      


Pro Pro Val Pro Ala Gln Lys Phe Ser Ala Leu Thr Phe Leu Arg Val 
            20                  25                  30          


Asp Gln Asp Lys Asp Lys Asp Cys Ser Leu Asp Cys Ala Gly Ser Pro 
        35                  40                  45              


Gln Lys Pro Leu Cys Ala Ser Asp Gly Arg Thr Phe Leu Ser Arg Cys 
    50                  55                  60                  


Glu Phe Gln Arg Ala Lys Cys Lys Asp Pro Gln Leu Glu Ile Ala Tyr 
65                  70                  75                  80  


Arg Gly Asn Cys Lys Asp Val Ser Arg Cys Val Ala Glu Arg Lys Tyr 
                85                  90                  95      


Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe Ile Pro Glu 
            100                 105                 110         


Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His Ser Tyr Thr 
        115                 120                 125             


Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Ile Ser Gly Thr 
    130                 135                 140                 


Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Val Asn Glu Lys 
145                 150                 155                 160 


Leu Pro Gln Arg Glu Gly Thr Gly Lys Thr Asp Asp Ala Ala Ala Pro 
                165                 170                 175     


Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu Glu Asp Ile Ala Ser Arg 
            180                 185                 190         


Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys Ser Arg Gln Asn Lys Thr 
        195                 200                 205             


Asn Lys Asn Ser Val Ser Ser Cys Asp Gln Glu His Gln Ser Ala Leu 
    210                 215                 220                 


Glu Glu Ala Lys Gln Pro Lys Asn Asp Asn Val Val Ile Pro Glu Cys 
225                 230                 235                 240 


Ala His Gly Gly Leu Tyr Lys Pro Val Gln Cys His Pro Ser Thr Gly 
                245                 250                 255     


Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Ile Pro Gly Thr 
            260                 265                 270         


Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp Asn Thr Ala Arg Ala His 
        275                 280                 285             


Pro Ala Lys Ala Arg Asp Leu Tyr Lys Gly Arg Gln Leu Gln Gly Cys 
    290                 295                 300                 


Pro Gly Ala Lys Lys His Glu Phe Leu Thr Ser Val Leu Asp Ala Leu 
305                 310                 315                 320 


Ser Thr Asp Met Val His Ala Ala Ser Asp Pro Ser Ser Ser Ser Gly 
                325                 330                 335     


Arg Leu Ser Glu Pro Asp Pro Ser His Thr Leu Glu Glu Arg Val Val 
            340                 345                 350         


His Trp Tyr Phe Lys Leu Leu Asp Lys Asn Ser Ser Gly Asp Ile Gly 
        355                 360                 365             


Lys Lys Glu Ile Lys Pro Phe Lys Arg Phe Leu Arg Lys Lys Ser Lys 
    370                 375                 380                 


Pro Lys Lys Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Val Asn Asn 
385                 390                 395                 400 


Asp Lys Ser Ile Ser Val Gln Glu Leu Met Gly Cys Leu Gly Val Ala 
                405                 410                 415     


Lys Glu Asp Gly Lys Ala Asp Thr Lys Lys Arg His Thr Pro Arg Gly 
            420                 425                 430         


His Val Glu Ser Thr Ser Asn Arg Gln Pro Arg Lys Gln Gly 
        435                 440                 445     


<210>  2
<211>  400
<212>  PRT
<213>  Human

<400>  2

Met Leu Leu Pro Gln Leu Cys Trp Leu Pro Leu Leu Ala Gly Leu Leu 
1               5                   10                  15      


Pro Pro Val Pro Ala Gln Lys Phe Ser Ala Leu Thr Phe Leu Arg Val 
            20                  25                  30          


Asp Gln Asp Lys Asp Lys Lys Asp Val Ser Arg Cys Val Ala Glu Arg 
        35                  40                  45              


Lys Tyr Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe Ile 
    50                  55                  60                  


Pro Glu Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His Ser 
65                  70                  75                  80  


Tyr Thr Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Ile Ser 
                85                  90                  95      


Gly Thr Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Val Asn 
            100                 105                 110         


Glu Lys Leu Pro Gln Arg Glu Gly Thr Gly Lys Thr Asp Asp Ala Ala 
        115                 120                 125             


Ala Pro Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu Glu Asp Ile Ala 
    130                 135                 140                 


Ser Arg Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys Ser Arg Gln Asn 
145                 150                 155                 160 


Lys Thr Asn Lys Asn Ser Val Ser Ser Cys Asp Gln Glu His Gln Ser 
                165                 170                 175     


Ala Leu Glu Glu Ala Lys Gln Pro Lys Asn Asp Asn Val Val Ile Pro 
            180                 185                 190         


Glu Cys Ala His Gly Gly Leu Tyr Lys Pro Val Gln Cys His Pro Ser 
        195                 200                 205             


Thr Gly Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Ile Pro 
    210                 215                 220                 


Gly Thr Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp Asn Thr Ala Arg 
225                 230                 235                 240 


Ala His Pro Ala Lys Ala Arg Asp Leu Tyr Lys Gly Arg Gln Leu Gln 
                245                 250                 255     


Gly Cys Pro Gly Ala Lys Lys His Glu Phe Leu Thr Ser Val Leu Asp 
            260                 265                 270         


Ala Leu Ser Thr Asp Met Val His Ala Ala Ser Asp Pro Ser Ser Ser 
        275                 280                 285             


Ser Gly Arg Leu Ser Glu Pro Asp Pro Ser His Thr Leu Glu Glu Arg 
    290                 295                 300                 


Val Val His Trp Tyr Phe Lys Leu Leu Asp Lys Asn Ser Ser Gly Asp 
305                 310                 315                 320 


Ile Gly Lys Lys Glu Ile Lys Pro Phe Lys Arg Phe Leu Arg Lys Lys 
                325                 330                 335     


Ser Lys Pro Lys Lys Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Val 
            340                 345                 350         


Asn Asn Asp Lys Ser Ile Ser Val Gln Glu Leu Met Gly Cys Leu Gly 
        355                 360                 365             


Val Ala Lys Glu Asp Gly Lys Ala Asp Thr Lys Lys Arg His Thr Pro 
    370                 375                 380                 


Arg Gly His Ala Glu Ser Thr Ser Asn Arg Gln Pro Arg Lys Gln Gly 
385                 390                 395                 400 


<210>  3
<211>  447
<212>  PRT
<213>  Mouse

<400>  3

Met Leu Pro Pro Gln Leu Cys Trp Leu Pro Leu Leu Ala Ala Leu Leu 
1               5                   10                  15      


Pro Pro Val Pro Ala Gln Lys Phe Ser Ala Leu Thr Phe Leu Arg Val 
            20                  25                  30          


Asp Gln Asp Lys Asp Arg Asp Cys Ser Leu Asp Cys Pro Ser Ser Pro 
        35                  40                  45              


Gln Lys Pro Leu Cys Ala Ser Asp Gly Arg Thr Phe Leu Ser Arg Cys 
    50                  55                  60                  


Glu Phe Gln Arg Ala Lys Cys Lys Asp Pro Gln Leu Glu Ile Ala His 
65                  70                  75                  80  


Arg Gly Asn Cys Lys Asp Val Ser Arg Cys Val Ala Glu Arg Lys Tyr 
                85                  90                  95      


Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe Ile Pro Glu 
            100                 105                 110         


Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His Ser Tyr Thr 
        115                 120                 125             


Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Ile Ser Gly Thr 
    130                 135                 140                 


Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Ile Asn Glu Lys 
145                 150                 155                 160 


Val Pro Gln Arg Glu Gly Ala Gly Lys Ala Asp Asp Ala Ala Ala Pro 
                165                 170                 175     


Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu Glu Asp Ile Ala Ser Arg 
            180                 185                 190         


Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys Ser Arg Gln Asn Lys Thr 
        195                 200                 205             


Asn Lys Asn Ser Ala Ser Ser Cys Asp Gln Glu His Gln Ser Ala Leu 
    210                 215                 220                 


Glu Glu Ala Lys Gln Pro Lys Asn Asp Asn Val Val Ile Pro Glu Cys 
225                 230                 235                 240 


Ala His Gly Gly Leu Tyr Lys Pro Val Gln Cys His Pro Ser Thr Gly 
                245                 250                 255     


Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Ile Pro Gly Thr 
            260                 265                 270         


Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp Asn Thr Ala Arg Ala His 
        275                 280                 285             


Pro Ala Lys Ala Arg Asp Leu Tyr Lys Asn Arg Pro Leu Gln Gly Cys 
    290                 295                 300                 


Pro Gly Ala Lys Lys His Glu Phe Leu Thr Ser Val Leu Asp Ala Leu 
305                 310                 315                 320 


Ser Thr Asp Met Val His Ala Val Ser Asp Pro Ser Ser Ser Ser Gly 
                325                 330                 335     


Arg Leu Ser Glu Pro Asp Pro Ser His Thr Leu Glu Glu Arg Val Val 
            340                 345                 350         


His Trp Tyr Phe Lys Leu Leu Asp Lys Asn Ser Ser Gly Asp Ile Gly 
        355                 360                 365             


Lys Lys Glu Ile Lys Pro Phe Lys Arg Phe Leu Arg Lys Lys Ser Lys 
    370                 375                 380                 


Pro Lys Lys Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Met Asn Asn 
385                 390                 395                 400 


Asp Lys Ser Ile Thr Val Gln Glu Leu Met Gly Cys Leu Gly Val Thr 
                405                 410                 415     


Arg Glu Glu Gly Lys Ala Asn Thr Arg Lys Arg His Thr Pro Arg Gly 
            420                 425                 430         


Asn Ala Glu Ser Ser Ser Ser Asn Arg Gln Pro Arg Lys Gln Gly 
        435                 440                 445         


<210>  4
<211>  401
<212>  PRT
<213>  Mouse

<400>  4

Met Leu Pro Pro Gln Leu Cys Trp Leu Pro Leu Leu Ala Ala Leu Leu 
1               5                   10                  15      


Pro Pro Val Pro Ala Gln Lys Phe Ser Ala Leu Thr Phe Leu Arg Val 
            20                  25                  30          


Asp Gln Asp Lys Asp Arg Lys Asp Val Ser Arg Cys Val Ala Glu Arg 
        35                  40                  45              


Lys Tyr Thr Gln Glu Gln Ala Arg Lys Glu Phe Gln Gln Val Phe Ile 
    50                  55                  60                  


Pro Glu Cys Asn Asp Asp Gly Thr Tyr Ser Gln Val Gln Cys His Ser 
65                  70                  75                  80  


Tyr Thr Gly Tyr Cys Trp Cys Val Thr Pro Asn Gly Arg Pro Ile Ser 
                85                  90                  95      


Gly Thr Ala Val Ala His Lys Thr Pro Arg Cys Pro Gly Ser Ile Asn 
            100                 105                 110         


Glu Lys Val Pro Gln Arg Glu Gly Ala Gly Lys Ala Asp Asp Ala Ala 
        115                 120                 125             


Ala Pro Ala Leu Glu Thr Gln Pro Gln Gly Asp Glu Glu Asp Ile Ala 
    130                 135                 140                 


Ser Arg Tyr Pro Thr Leu Trp Thr Glu Gln Val Lys Ser Arg Gln Asn 
145                 150                 155                 160 


Lys Thr Asn Lys Asn Ser Ala Ser Ser Cys Asp Gln Glu His Gln Ser 
                165                 170                 175     


Ala Leu Glu Glu Ala Lys Gln Pro Lys Asn Asp Asn Val Val Ile Pro 
            180                 185                 190         


Glu Cys Ala His Gly Gly Leu Tyr Lys Pro Val Gln Cys His Pro Ser 
        195                 200                 205             


Thr Gly Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Ile Pro 
    210                 215                 220                 


Gly Thr Ser Thr Arg Tyr Glu Gln Pro Lys Cys Asp Asn Thr Ala Arg 
225                 230                 235                 240 


Ala His Pro Ala Lys Ala Arg Asp Leu Tyr Lys Asn Arg Pro Leu Gln 
                245                 250                 255     


Gly Cys Pro Gly Ala Lys Lys His Glu Phe Leu Thr Ser Val Leu Asp 
            260                 265                 270         


Ala Leu Ser Thr Asp Met Val His Ala Val Ser Asp Pro Ser Ser Ser 
        275                 280                 285             


Ser Gly Arg Leu Ser Glu Pro Asp Pro Ser His Thr Leu Glu Glu Arg 
    290                 295                 300                 


Val Val His Trp Tyr Phe Lys Leu Leu Asp Lys Asn Ser Ser Gly Asp 
305                 310                 315                 320 


Ile Gly Lys Lys Glu Ile Lys Pro Phe Lys Arg Phe Leu Arg Lys Lys 
                325                 330                 335     


Ser Lys Pro Lys Lys Cys Val Lys Lys Phe Val Glu Tyr Cys Asp Met 
            340                 345                 350         


Asn Asn Asp Lys Ser Ile Thr Val Gln Glu Leu Met Gly Cys Leu Gly 
        355                 360                 365             


Val Thr Arg Glu Glu Gly Lys Ala Asn Thr Arg Lys Arg His Thr Pro 
    370                 375                 380                 


Arg Gly Asn Ala Glu Ser Ser Ser Ser Asn Arg Gln Pro Arg Lys Gln 
385                 390                 395                 400 


Gly 
    


