                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  TRIMERIC ANTIGEN BINDING MOLECULES

<130>  31450 WO

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  496
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Full length human CMP

<400>  1

Met Arg Val Leu Ser Gly Thr Ser Leu Met Leu Cys Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gln Ala Leu Cys Ser Pro Gly Leu Ala Pro Gln Ser Arg Gly 
            20                  25                  30          


His Leu Cys Arg Thr Arg Pro Thr Asp Leu Val Phe Val Val Asp Ser 
        35                  40                  45              


Ser Arg Ser Val Arg Pro Val Glu Phe Glu Lys Val Lys Val Phe Leu 
    50                  55                  60                  


Ser Gln Val Ile Glu Ser Leu Asp Val Gly Pro Asn Ala Thr Arg Val 
65                  70                  75                  80  


Gly Met Val Asn Tyr Ala Ser Thr Val Lys Gln Glu Phe Ser Leu Arg 
                85                  90                  95      


Ala His Val Ser Lys Ala Ala Leu Leu Gln Ala Val Arg Arg Ile Gln 
            100                 105                 110         


Pro Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Phe Ala Ile 
        115                 120                 125             


Thr Lys Ala Phe Gly Asp Ala Glu Gly Gly Arg Ser Arg Ser Pro Asp 
    130                 135                 140                 


Ile Ser Lys Val Val Ile Val Val Thr Asp Gly Arg Pro Gln Asp Ser 
145                 150                 155                 160 


Val Gln Asp Val Ser Ala Arg Ala Arg Ala Ser Gly Val Glu Leu Phe 
                165                 170                 175     


Ala Ile Gly Val Gly Ser Val Asp Lys Ala Thr Leu Arg Gln Ile Ala 
            180                 185                 190         


Ser Glu Pro Gln Asp Glu His Val Asp Tyr Val Glu Ser Tyr Ser Val 
        195                 200                 205             


Ile Glu Lys Leu Ser Arg Lys Phe Gln Glu Ala Phe Cys Val Val Ser 
    210                 215                 220                 


Asp Leu Cys Ala Thr Gly Asp His Asp Cys Glu Gln Val Cys Ile Ser 
225                 230                 235                 240 


Ser Pro Gly Ser Tyr Thr Cys Ala Cys His Glu Gly Phe Thr Leu Asn 
                245                 250                 255     


Ser Asp Gly Lys Thr Cys Asn Val Cys Ser Gly Gly Gly Gly Ser Ser 
            260                 265                 270         


Ala Thr Asp Leu Val Phe Leu Ile Asp Gly Ser Lys Ser Val Arg Pro 
        275                 280                 285             


Glu Asn Phe Glu Leu Val Lys Lys Phe Ile Ser Gln Ile Val Asp Thr 
    290                 295                 300                 


Leu Asp Val Ser Asp Lys Leu Ala Gln Val Gly Leu Val Gln Tyr Ser 
305                 310                 315                 320 


Ser Ser Val Arg Gln Glu Phe Pro Leu Gly Arg Phe His Thr Lys Lys 
                325                 330                 335     


Asp Ile Lys Ala Ala Val Arg Asn Met Ser Tyr Met Glu Lys Gly Thr 
            340                 345                 350         


Met Thr Gly Ala Ala Leu Lys Tyr Leu Ile Asp Asn Ser Phe Thr Val 
        355                 360                 365             


Ser Ser Gly Ala Arg Pro Gly Ala Gln Lys Val Gly Ile Val Phe Thr 
    370                 375                 380                 


Asp Gly Arg Ser Gln Asp Tyr Ile Asn Asp Ala Ala Lys Lys Ala Lys 
385                 390                 395                 400 


Asp Leu Gly Phe Lys Met Phe Ala Val Gly Val Gly Asn Ala Val Glu 
                405                 410                 415     


Asp Glu Leu Arg Glu Ile Ala Ser Glu Pro Val Ala Glu His Tyr Phe 
            420                 425                 430         


Tyr Thr Ala Asp Phe Lys Thr Ile Asn Gln Ile Gly Lys Lys Leu Gln 
        435                 440                 445             


Lys Lys Ile Cys Val Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu Val 
    450                 455                 460                 


Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys 
465                 470                 475                 480 


Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val Val 
                485                 490                 495     


<210>  2
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CMP trimerization domain

<400>  2

Cys Ala Cys Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu 
1               5                   10                  15      


Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala 
            20                  25                  30          


Ile Leu Glu Asn Thr Val Val 
        35                  


<210>  3
<211>  308
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VHCH1-CMP-Flag DR5 clone 2A11 

<400>  3

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Pro Tyr Gly Arg Tyr Ala Ala Leu Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp 
                245                 250                 255     


Pro Cys Ala Cys Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly 
            260                 265                 270         


Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu 
        275                 280                 285             


Ala Ile Leu Glu Asn Thr Val Val Ala Ser Asp Tyr Lys Asp Asp Asp 
    290                 295                 300                 


Asp Lys Ser Gly 
305             


<210>  4
<211>  305
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VHCH1-CMP-Flag DR5 clone 5E11

<400>  4

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gly Val Arg Val Ser Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala 
                245                 250                 255     


Cys Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln 
            260                 265                 270         


Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu 
        275                 280                 285             


Glu Asn Thr Val Val Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Ser 
    290                 295                 300                 


Gly 
305 


<210>  5
<211>  528
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR5 (5E11) Fab molecule- CMP-_FAP(28H1)CrossFab

<400>  5

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Val Arg Val Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala Cys Glu Ser 
225                 230                 235                 240 


Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr 
                245                 250                 255     


Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr 
            260                 265                 270         


Val Val Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
305                 310                 315                 320 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
                325                 330                 335     


His Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            340                 345                 350         


Val Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val 
        355                 360                 365             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    370                 375                 380                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
385                 390                 395                 400 


Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
                405                 410                 415     


Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe 
            420                 425                 430         


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
        435                 440                 445             


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
    450                 455                 460                 


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
465                 470                 475                 480 


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
                485                 490                 495     


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
            500                 505                 510         


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        515                 520                 525             


<210>  6
<211>  289
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DR5 (5E11) Fab molecule- CMP-_FAP(28H1) scFv VHCH1-CMP-VHVL

<400>  6

Gly Ser Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu Val Lys Phe Gln 
1               5                   10                  15      


Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala 
            20                  25                  30          


Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val Val Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    50                  55                  60                  


Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
65                  70                  75                  80  


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                85                  90                  95      


Ser His Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            100                 105                 110         


Trp Val Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser 
        115                 120                 125             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
    130                 135                 140                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
145                 150                 155                 160 


Cys Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
                165                 170                 175     


Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile 
            180                 185                 190         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        195                 200                 205             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
    210                 215                 220                 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
225                 230                 235                 240 


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
                245                 250                 255     


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
            260                 265                 270         


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
        275                 280                 285             


Cys 
    


<210>  7
<211>  289
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CMP-FAP(28H1) CrossFab

<400>  7

Gly Ser Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu Val Lys Phe Gln 
1               5                   10                  15      


Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala 
            20                  25                  30          


Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val Val Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    50                  55                  60                  


Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
65                  70                  75                  80  


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                85                  90                  95      


Ser His Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            100                 105                 110         


Trp Val Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser 
        115                 120                 125             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
    130                 135                 140                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
145                 150                 155                 160 


Cys Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
                165                 170                 175     


Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile 
            180                 185                 190         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        195                 200                 205             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
    210                 215                 220                 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
225                 230                 235                 240 


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
                245                 250                 255     


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
            260                 265                 270         


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
        275                 280                 285             


Cys 
    


<210>  8
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VLCL DR5 clone 2A11

<400>  8

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile 
        35                  40                  45              


Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  9
<211>  234
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VLCL DR5 clone 5E11

<400>  9

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Thr 
            100                 105                 110         


Thr His Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  10
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VLCH1 FAP clone 28H1

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
        195                 200                 205             


Glu Pro Lys Ser Cys Asp 
    210                 


<210>  11
<211>  924
<212>  DNA
<213>  Artificial sequence

<220>
<223>  VHCH1-CMP-Flag DR5 clone 2A11

<400>  11
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgcaattgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      120

tgtgcagcct ccggattcac ctttagcagt tatgccatga gctgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca      240

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgcg tggtccgtac      360

ggtcgttacg ctgctctgga ctactggggc caaggaaccc tggtcaccgt ctcgagtgct      420

agcacaaagg gacctagcgt gttccccctg gcccccagca gcaagtctac atctggcgga      480

acagccgccc tgggctgcct cgtgaaggac tactttcccg agcccgtgac cgtgtcctgg      540

aactctggcg ctctgacaag cggcgtgcac acctttccag ccgtgctgca gagcagcggc      600

ctgtactctc tgagcagcgt cgtgacagtg cccagcagct ctctgggcac ccagacctac      660

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggaacccaag      720

agctgcgacg gcggaggggg atctggcggc ggaggatccg aagaagatcc ttgcgcctgc      780

gagagcctcg tgaaattcca ggccaaggtg gaaggactgc tgcaggccct gacccggaaa      840

ctggaagccg tgtccaagcg gctggccatc ctggaaaaca ccgtggtggc cagcgactac      900

aaggacgacg acgacaagtc cgga                                             924


<210>  12
<211>  915
<212>  DNA
<213>  Artificial sequence

<220>
<223>  VHCH1-CMP-Flag DR5 clone 5E11

<400>  12
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgag       60

gtgcaattgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      120

tgtgcagcct ccggattcac ctttagcagt tatgccatga gctgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca      240

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa aggggtgagg      360

gtgtcttttg actactgggg ccaaggaacc ctggtcaccg tctcgagtgc tagcacaaag      420

ggacctagcg tgttccccct ggcccccagc agcaagtcta catctggcgg aacagccgcc      480

ctgggctgcc tcgtgaagga ctactttccc gagcccgtga ccgtgtcctg gaactctggc      540

gctctgacaa gcggcgtgca cacctttcca gccgtgctgc agagcagcgg cctgtactct      600

ctgagcagcg tcgtgacagt gcccagcagc tctctgggca cccagaccta catctgcaac      660

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggaacccaa gagctgcgac      720

ggcggagggg gatctggcgg cggaggatcc gaagaagatc cttgcgcctg cgagagcctc      780

gtgaaattcc aggccaaggt ggaaggactg ctgcaggccc tgacccggaa actggaagcc      840

gtgtccaagc ggctggccat cctggaaaac accgtggtgg ccagcgacta caaggacgac      900

gacgacaagt ccgga                                                       915


<210>  13
<211>  1584
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5E11_28H1 CrossFab VHCH1-CMP-VHCL

<400>  13
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggggtg      300

agggtgtctt ttgactactg gggccaagga accctggtca ccgtctcgag tgctagcaca      360

aagggaccta gcgtgttccc cctggccccc agcagcaagt ctacatctgg cggaacagcc      420

gccctgggct gcctcgtgaa ggactacttt cccgagcccg tgaccgtgtc ctggaactct      480

ggcgctctga caagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

tctctgagca gcgtcgtgac agtgcccagc agctctctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc      660

gacggcggag ggggatctgg cggcggagga tccgaagaag atccttgcgc ctgcgagagc      720

ctcgtgaaat tccaggccaa ggtggaagga ctgctgcagg ccctgacccg gaaactggaa      780

gccgtgtcca agcggctggc catcctggaa aacaccgtgg tggccagcga ctacaaggac      840

gacgacgaca agtccggagg cggcggaagc ggaggaggag gatccggagg agggggaagt      900

ggcggcggag gatctgaggt gcagctgctg gaatccggcg gaggcctggt gcagcctggc      960

ggatctctga gactgtcctg cgccgcctcc ggcttcacct tctcctccca cgccatgtcc     1020

tgggtccgac aggctcctgg caaaggcctg gaatgggtgt ccgccatctg ggcctccggc     1080

gagcagtact acgccgactc tgtgaagggc cggttcacca tctcccggga caactccaag     1140

aacaccctgt acctgcagat gaactccctg cgggccgagg acaccgccgt gtactactgt     1200

gccaagggct ggctgggcaa cttcgactac tggggccagg gcaccctggt caccgtgtcc     1260

agcgctagcg tggccgctcc cagcgtgttc atcttcccac ccagcgacga gcagctgaag     1320

tccggcacag ccagcgtggt gtgcctgctg aacaacttct acccccgcga ggccaaggtg     1380

cagtggaagg tggacaacgc cctgcagagc ggcaacagcc aggaatccgt gaccgagcag     1440

gacagcaagg actccaccta cagcctgagc agcaccctga ccctgagcaa ggccgactac     1500

gagaagcaca aggtgtacgc ctgcgaagtg acccaccagg gcctgtccag ccccgtgacc     1560

aagagcttca accggggcga gtgc                                            1584


<210>  14
<211>  1617
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5E11_28H1 scFv VHCH1-CMP-VHVL

<400>  14
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggggtg      300

agggtgtctt ttgactactg gggccaagga accctggtca ccgtctcgag tgctagcaca      360

aagggaccta gcgtgttccc cctggccccc agcagcaagt ctacatctgg cggaacagcc      420

gccctgggct gcctcgtgaa ggactacttt cccgagcccg tgaccgtgtc ctggaactct      480

ggcgctctga caagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

tctctgagca gcgtcgtgac agtgcccagc agctctctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc      660

gacggcggag ggggatctgg cggcggagga tccgaggaag atccttgcgc ctgcgagagc      720

ctcgtgaagt tccaggccaa ggtggaagga ctgctgcagg ccctgacccg gaaactggaa      780

gccgtgtcca agcggctggc catcctggaa aacaccgtgg tgtccggagg cgggggtagc      840

ggcggagggg gctctggcgg tggcgggtct ggaggcgggg gttcagaagt gcagctgctg      900

gaatctggcg gcggactggt gcagcctggc ggatctctga gactgagctg tgccgccagc      960

ggcttcacct ttagcagcca cgccatgagc tgggtgcgcc aggcccctgg aaagtgcctg     1020

gaatgggtgt ccgccatctg ggccagcggc gagcagtact acgccgatag cgtgaagggc     1080

cggttcacca tcagccggga caacagcaag aacaccctgt acctgcagat gaacagcctg     1140

cgggccgagg acaccgccgt gtactattgt gccaagggct ggctgggcaa cttcgactat     1200

tggggccagg gcaccctcgt gaccgtgtct agcggagggg gcggaagtgg tggcggggga     1260

agcggcgggg gtggcagcgg agggggcgga tctgaaattg tgctgaccca gagccctggc     1320

accctgagcc tgtctccagg cgaaagagcc acactgagct gcagagccag ccagagcgtg     1380

tccagaagct acctggcctg gtatcagcag aagcccggac aggcccccag actgctgatc     1440

atcggcgcct ctacaagagc caccggcatc cccgatagat tcagcggctc tggcagcggc     1500

accgacttca ccctgaccat cagcagactg gaacccgagg actttgccgt gtattactgc     1560

cagcagggcc aagtgatccc ccccaccttt ggctgtggca caaaggtgga aatcaaa        1617


<210>  15
<211>  867
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMP-28H1 CrossFab

<400>  15
ggatccgagg aagatccttg cgcctgcgag agcctcgtga agttccaggc caaggtggaa       60

ggactgctgc aggccctgac ccggaaactg gaagccgtgt ccaagcggct ggccatcctg      120

gaaaacaccg tggtgtccgg aggcggcgga agcggaggag gaggatccgg aggaggggga      180

agtggcggcg gaggatctga ggtgcagctg ctggaatccg gcggaggcct ggtgcagcct      240

ggcggatctc tgagactgtc ctgcgccgcc tccggcttca ccttctcctc ccacgccatg      300

tcctgggtcc gacaggctcc tggcaaaggc ctggaatggg tgtccgccat ctgggcctcc      360

ggcgagcagt actacgccga ctctgtgaag ggccggttca ccatctcccg ggacaactcc      420

aagaacaccc tgtacctgca gatgaactcc ctgcgggccg aggacaccgc cgtgtactac      480

tgtgccaagg gctggctggg caacttcgac tactggggcc agggcaccct ggtcaccgtg      540

tccagcgcta gcgtggccgc tcccagcgtg ttcatcttcc cacccagcga cgagcagctg      600

aagtccggca cagccagcgt ggtgtgcctg ctgaacaact tctacccccg cgaggccaag      660

gtgcagtgga aggtggacaa cgccctgcag agcggcaaca gccaggaatc cgtgaccgag      720

caggacagca aggactccac ctacagcctg agcagcaccc tgaccctgag caaggccgac      780

tacgagaagc acaaggtgta cgcctgcgaa gtgacccacc agggcctgtc cagccccgtg      840

accaagagct tcaaccgggg cgagtgc                                          867


<210>  16
<211>  699
<212>  DNA
<213>  Artificial sequence

<220>
<223>  VLCL DR5 clone 2A11

<400>  16
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgac       60

atccagatga cccagagccc cagcagcctg agcgccagcg tgggcgacag agtgaccatc      120

acctgcagcg ccagccaggg catccggaac tacctgaact ggtatcagca gaagcccggc      180

aaggccccca agctgctgat ctactacacc agcagcctgc acagcggcgt gcctagccgg      240

tttagcggca gcggctccgg caccgacttc accctgacca ttagctccct gcagcccgag      300

gacttcgcca cctactactg ccagcagtac agcaagctgc cctggacctt cggccaggga      360

acaaaggtgg agatcaagcg tacggtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             699


<210>  17
<211>  702
<212>  DNA
<213>  Artificial sequence

<220>
<223>  VLCL DR5 clone 5E11

<400>  17
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggtgt gcattccgaa       60

atcgtgttaa cgcagtctcc aggcaccctg tctttgtctc caggggaaag agccaccctc      120

tcttgcaggg ccagtcagag tgttagcagc agctacttag cctggtacca gcagaaacct      180

ggccaggctc ccaggctcct catctatgga gcatccagca gggccactgg catcccagac      240

aggttcagtg gcagtggatc cgggacagac ttcactctca ccatcagcag actggagcct      300

gaagattttg cagtgtatta ctgtcagcag ggtactactc atcccattac gttcggccag      360

gggaccaaag tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         702


<210>  18
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  VLCH1FAP clone 28H1

<400>  18
gagatcgtgc tgacccagtc tcccggcacc ctgagcctga gccctggcga gagagccacc       60

ctgagctgca gagccagcca gagcgtgagc cggagctacc tggcctggta tcagcagaag      120

cccggccagg cccccagact gctgatcatc ggcgccagca cccgggccac cggcatcccc      180

gatagattca gcggcagcgg ctccggcacc gacttcaccc tgaccatcag ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagggccagg tgatcccccc caccttcggc      300

cagggcacca aggtggaaat caagagctcc gctagcacca agggcccctc cgtgtttcct      360

ctggccccca gcagcaagag cacctctggc ggaacagccg ccctgggctg cctggtgaaa      420

gactacttcc ccgagcccgt gaccgtgtcc tggaactctg gcgccctgac cagcggcgtg      480

cacacctttc cagccgtgct gcagagcagc ggcctgtact ccctgagcag cgtggtgaca      540

gtgccctcca gcagcctggg cacccagacc tacatctgca acgtgaacca caagcccagc      600

aacaccaaag tggacaagaa ggtggaaccc aagagctgcg ac                         642


<210>  19
<211>  561
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Digoxigenin(Fab-HC)-CMP-anti-CEA(scFv)Digoxigenin

<400>  19

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ser Ile Asn Ile Gly Ala Thr Tyr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Pro Gly Ser Pro Tyr Glu Tyr Asp Lys Ala Tyr 
        115                 120                 125             


Tyr Ser Met Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu Val 
            260                 265                 270         


Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys 
        275                 280                 285             


Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val Val 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Glu Gln 
305                 310                 315                 320 


Ser Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys 
                325                 330                 335     


Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg 
            340                 345                 350         


Gln Gly Pro Gly Gln Cys Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu 
        355                 360                 365             


Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe 
    370                 375                 380                 


Thr Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu 
385                 390                 395                 400 


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr 
                405                 410                 415     


Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            420                 425                 430         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro Ser Ser 
    450                 455                 460                 


Met Ser Val Ser Val Gly Asp Arg Val Thr Ile Ala Cys Ser Ala Ser 
465                 470                 475                 480 


Ser Ser Val Pro Tyr Met His Trp Leu Gln Gln Lys Pro Gly Lys Ser 
                485                 490                 495     


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
            500                 505                 510         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
        515                 520                 525             


Ser Ser Val Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg 
    530                 535                 540                 


Ser Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
545                 550                 555                 560 


Arg 
    


<210>  20
<211>  234
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-Digoxigenin(Fab-LC)

<400>  20

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Lys Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ser Ser Thr Leu Leu Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ile 
            100                 105                 110         


Thr Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  21
<211>  1686
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-Digoxigenin(Fab-HC)-CMP-anti-CEA(scFv)

<400>  21
atgggctggt cctgcatcat cctgtttctg gtggccaccg ctaccggcgt ccatagccag       60

gtgcagctgg tggaaagcgg cggaggcctg gtgaaaccgg gaggctctct gagactgtct      120

tgcgctgcga gcggctttac ctttagcgat tatgcgatga gctggattcg ccaggcgccg      180

ggcaaaggcc tggaatgggt gagcagcatt aacattggcg cgacctatat ttattatgcg      240

gatagcgtga aaggccgctt taccattagc cgcgataacg cgaaaaacag cctgtatctg      300

cagatgaata gcctcagagc ggaagataca gcggtgtatt attgcgcgcg cccgggcagc      360

ccgtatgaat atgataaagc gtattatagc atggcgtatt ggggccaggg caccaccgtg      420

acagtgagca gcgcgtcgac taagggccct tcagtttttc cactcgcccc cagtagcaag      480

tccacatctg ggggtaccgc tgccctgggc tgccttgtga aagactattt ccctgaacca      540

gtcactgtgt catggaatag cggagccctg acctccggtg tacacacatt ccccgctgtg      600

ttgcagtcta gtggcctgta cagcctctcc tctgttgtga ccgtcccttc aagctccctg      660

gggacacaga cctatatctg taacgtgaat cataagccat ctaacactaa ggtagataaa      720

aaagtggagc ccaagagttg cgacaaaaca cacggaggtg gtggatctgg cggaggtggc      780

agtgaggaag acccctgcgc ctgtgagagc ctggtgaagt tccaggctaa agtcgagggc      840

ctcctgcagg cacttaccag gaagctggaa gccgtgtcca agagactcgc tatcctggag      900

aacacagtcg tgggcggagg cggttcaggg ggaggcggta gccaagtgaa gctggagcag      960

agcggcgccg aagtcgtgaa acccggggct tccgtcaagc tctcttgcaa ggcatcagga     1020

ttcaacatca aagacagcta catgcactgg ctgaggcagg gccctggtca gtgccttgag     1080

tggattggct ggatcgatcc agagaatggc gacaccgaat atgcccccaa gtttcaagga     1140

aaggctacat tcaccactga tacatccgca aacaccgcct acctgggtct ctcaagtctg     1200

cgccctgagg acactgctgt gtattactgt aatgagggca ccccaacagg gccctactat     1260

tttgactact ggggacaggg caccttggtt acagtgagct ccgggggagg cggttccggg     1320

ggcggaggtt ctgggggcgg aggttctggc gggggaggct cagagaacgt gctgacccag     1380

agcccctcct ctatgtcagt cagcgtgggc gacagggtca caatcgcctg ctccgcttct     1440

agtagcgtgc cttacatgca ctggctccag cagaagccag ggaaatcccc caagctgctt     1500

atttattcta cctcaaatct ggcaagcgga gttcctagca gattctctgg cagtggtagc     1560

gggactgatt actccctcac aatctcaagt gtgcagccag aagacgccgc tacctattac     1620

tgtcaacagc gcagctccta ccccctgact tttggctgtg gcaccaagtt ggagattaaa     1680

cggtga                                                                1686


<210>  22
<211>  705
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti-Digoxigenin(Fab-LC)

<400>  22
atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      120

attacctgcc gcgcgagcca ggatattaaa aactatctga actggtatca gcagaaaccg      180

ggcaaagcgc cgaaactgct gatttattat agcagcaccc tgctgagcgg cgtgccgagc      240

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      300

gaagattttg cgacctatta ttgccagcag agcattaccc tgccgccgac ctttggcggc      360

ggcaccaaag tggaaattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      705


