                         SEQUENCE LISTING

<110>  Emmetrope Ophthalmics LLC
 
<120>  Identification and Isolation of Human Corneal Endothelial Cells 
       (HECS)

<130>  4071/7PCT

<140>  PCT/US2014/036616
<141>  2014-05-02

<150>  US 61/819,146
<151>  2013-05-03

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
            500                 505                 510         


Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
        515                 520                 525             


Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
    530                 535                 540                 


Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 
545                 550                 555                 560 


Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                565                 570                 575     


Asn Asn His Lys Thr Glu Ala 
            580             


<210>  2
<211>  1023
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Lys Gly Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
        115                 120                 125             


Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
785                 790                 795                 800 


Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  3
<211>  1023
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Phe Lys Val Gly Arg Asp Lys Tyr Glu Pro Ala Ala Val Ser 
1               5                   10                  15      


Glu Gln Gly Asp Lys Lys Gly Lys Lys Gly Lys Lys Asp Arg Asp Met 
            20                  25                  30          


Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser Leu 
        35                  40                  45              


Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu Thr 
    50                  55                  60                  


Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala Leu 
65                  70                  75                  80  


Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln Leu 
                85                  90                  95      


Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe 
            100                 105                 110         


Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn Asp 
        115                 120                 125             


Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr Gly 
    130                 135                 140                 


Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu Ser 
145                 150                 155                 160 


Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly Glu 
                165                 170                 175     


Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu 
            180                 185                 190         


Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser Ala 
        195                 200                 205             


Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro 
    210                 215                 220                 


Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr Arg 
225                 230                 235                 240 


Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly 
                245                 250                 255     


Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr 
            260                 265                 270         


Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu Ile 
        275                 280                 285             


Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly Val 
    290                 295                 300                 


Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu Ala 
305                 310                 315                 320 


Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu 
                325                 330                 335     


Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala 
            340                 345                 350         


Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly 
        355                 360                 365             


Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
    370                 375                 380                 


Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala 
385                 390                 395                 400 


Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser Ala 
                405                 410                 415     


Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val 
            420                 425                 430         


Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val Ala 
        435                 440                 445             


Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys Cys 
    450                 455                 460                 


Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu Ile 
465                 470                 475                 480 


Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn Pro 
                485                 490                 495     


Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro Glu 
            500                 505                 510         


Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu Gln 
        515                 520                 525             


Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe Leu 
545                 550                 555                 560 


Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp Val 
                565                 570                 575     


Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met Ile 
            580                 585                 590         


Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser 
        595                 600                 605             


Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala 
    610                 615                 620                 


Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr 
625                 630                 635                 640 


Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val Asn 
                645                 650                 655     


Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp 
            660                 665                 670         


Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu Ile 
        675                 680                 685             


Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly 
    690                 695                 700                 


Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn 
705                 710                 715                 720 


Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly Ile 
                725                 730                 735     


Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp 
            740                 745                 750         


Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile 
        755                 760                 765             


Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile 
    770                 775                 780                 


Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro Leu 
785                 790                 795                 800 


Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met 
                805                 810                 815     


Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile Met 
            820                 825                 830         


Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu Arg 
        835                 840                 845             


Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly 
    850                 855                 860                 


Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro 
865                 870                 875                 880 


Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile Asn 
                885                 890                 895     


Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg Lys 
            900                 905                 910         


Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val Val 
        915                 920                 925             


Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser Val 
    930                 935                 940                 


Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe Glu 
945                 950                 955                 960 


Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val 
                965                 970                 975     


Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala Phe 
            980                 985                 990         


Pro Tyr Ser Leu Leu Ile Phe Val  Tyr Asp Glu Val Arg  Lys Leu Ile 
        995                 1000                 1005             


Ile Arg  Arg Arg Pro Gly Gly  Trp Val Glu Lys Glu  Thr Tyr Tyr 
    1010                 1015                 1020             


<210>  4
<211>  992
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Glu Leu Lys Lys Glu Val Ser Met Asp Asp His Lys Leu Ser 
1               5                   10                  15      


Leu Asp Glu Leu His Arg Lys Tyr Gly Thr Asp Leu Ser Arg Gly Leu 
            20                  25                  30          


Thr Ser Ala Arg Ala Ala Glu Ile Leu Ala Arg Asp Gly Pro Asn Ala 
        35                  40                  45              


Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Ile Lys Phe Cys Arg Gln 
    50                  55                  60                  


Leu Phe Gly Gly Phe Ser Met Leu Leu Trp Ile Gly Ala Ile Leu Cys 
65                  70                  75                  80  


Phe Leu Ala Tyr Ser Ile Gln Ala Ala Thr Glu Glu Glu Pro Gln Asn 
                85                  90                  95      


Asp Asn Leu Tyr Leu Gly Val Val Leu Ser Ala Val Val Ile Ile Thr 
            100                 105                 110         


Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Glu 
        115                 120                 125             


Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Asn Gly 
    130                 135                 140                 


Glu Lys Met Ser Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val 
145                 150                 155                 160 


Glu Val Lys Gly Gly Asp Arg Ile Pro Ala Asp Leu Arg Ile Ile Ser 
                165                 170                 175     


Ala Asn Gly Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu 
            180                 185                 190         


Pro Gln Thr Arg Ser Pro Asp Phe Thr Asn Glu Asn Pro Leu Glu Thr 
        195                 200                 205             


Arg Asn Ile Ala Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg 
    210                 215                 220                 


Gly Ile Val Val Tyr Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala 
225                 230                 235                 240 


Thr Leu Ala Ser Gly Leu Glu Gly Gly Gln Thr Pro Ile Ala Ala Glu 
                245                 250                 255     


Ile Glu His Phe Ile His Ile Ile Thr Gly Val Ala Val Phe Leu Gly 
            260                 265                 270         


Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Glu Tyr Thr Trp Leu Glu 
        275                 280                 285             


Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly 
    290                 295                 300                 


Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met 
305                 310                 315                 320 


Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu 
                325                 330                 335     


Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln 
            340                 345                 350         


Asn Arg Met Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu 
        355                 360                 365             


Ala Asp Thr Thr Glu Asn Gln Ser Gly Val Ser Phe Asp Lys Thr Ser 
    370                 375                 380                 


Ala Thr Trp Leu Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala 
385                 390                 395                 400 


Val Phe Gln Ala Asn Gln Glu Asn Leu Pro Ile Leu Lys Arg Ala Val 
                405                 410                 415     


Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Cys 
            420                 425                 430         


Cys Gly Ser Val Lys Glu Met Arg Glu Arg Tyr Ala Lys Ile Val Glu 
        435                 440                 445             


Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Lys Asn 
    450                 455                 460                 


Pro Asn Thr Ser Glu Pro Gln His Leu Leu Val Met Lys Gly Ala Pro 
465                 470                 475                 480 


Glu Arg Ile Leu Asp Arg Cys Ser Ser Ile Leu Leu His Gly Lys Glu 
                485                 490                 495     


Gln Pro Leu Asp Glu Glu Leu Lys Asp Ala Phe Gln Asn Ala Tyr Leu 
            500                 505                 510         


Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly Phe Cys His Leu Phe 
        515                 520                 525             


Leu Pro Asp Glu Gln Phe Pro Glu Gly Phe Gln Phe Asp Thr Asp Asp 
    530                 535                 540                 


Val Asn Phe Pro Ile Asp Asn Leu Cys Phe Val Gly Leu Ile Ser Met 
545                 550                 555                 560 


Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg 
                565                 570                 575     


Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr 
            580                 585                 590         


Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu 
        595                 600                 605             


Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile Pro Val Ser Gln Val 
    610                 615                 620                 


Asn Pro Arg Asp Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys 
625                 630                 635                 640 


Asp Met Thr Ser Glu Gln Leu Asp Asp Ile Leu Lys Tyr His Thr Glu 
                645                 650                 655     


Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu 
            660                 665                 670         


Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val 
        675                 680                 685             


Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile Gly Val Ala Met Gly 
    690                 695                 700                 


Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu 
705                 710                 715                 720 


Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu 
                725                 730                 735     


Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn 
            740                 745                 750         


Ile Pro Glu Ile Thr Pro Phe Leu Ile Phe Ile Ile Ala Asn Ile Pro 
        755                 760                 765             


Leu Pro Leu Gly Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp 
    770                 775                 780                 


Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Gln Ala Glu Ser Asp Ile 
785                 790                 795                 800 


Met Lys Arg Gln Pro Arg Asn Pro Lys Thr Asp Lys Leu Val Asn Glu 
                805                 810                 815     


Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu 
            820                 825                 830         


Gly Gly Phe Phe Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu 
        835                 840                 845             


Pro Ile His Leu Leu Gly Leu Arg Val Asp Trp Asp Asp Arg Trp Ile 
    850                 855                 860                 


Asn Asp Val Glu Asp Ser Tyr Gly Gln Gln Trp Thr Tyr Glu Gln Arg 
865                 870                 875                 880 


Lys Ile Val Glu Phe Thr Cys His Thr Ala Phe Phe Val Ser Ile Val 
                885                 890                 895     


Val Val Gln Trp Ala Asp Leu Val Ile Cys Lys Thr Arg Arg Asn Ser 
            900                 905                 910         


Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Phe 
        915                 920                 925             


Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly 
    930                 935                 940                 


Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Thr Trp Trp Phe Cys Ala 
945                 950                 955                 960 


Phe Pro Tyr Ser Leu Leu Ile Phe Val Tyr Asp Glu Val Arg Lys Leu 
                965                 970                 975     


Ile Ile Arg Arg Arg Pro Gly Gly Trp Val Glu Lys Glu Thr Tyr Tyr 
            980                 985                 990         


<210>  5
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Arg Leu Thr Leu Thr Arg Thr Ile Gly Gly Pro Leu Leu Thr 
1               5                   10                  15      


Ala Thr Leu Leu Gly Lys Thr Thr Ile Asn Asp Tyr Gln Val Ile Arg 
            20                  25                  30          


Met Pro Phe Ser His Leu Ser Thr Tyr Ser Leu Val Trp Val Met Ala 
        35                  40                  45              


Ala Val Val Leu Cys Thr Ala Gln Val Gln Val Val Thr Gln Asp Glu 
    50                  55                  60                  


Arg Glu Gln Leu Tyr Thr Pro Ala Ser Leu Lys Cys Ser Leu Gln Asn 
65                  70                  75                  80  


Ala Gln Glu Ala Leu Ile Val Thr Trp Gln Lys Lys Lys Ala Val Ser 
                85                  90                  95      


Pro Glu Asn Met Val Thr Phe Ser Glu Asn His Gly Val Val Ile Gln 
            100                 105                 110         


Pro Ala Tyr Lys Asp Lys Ile Asn Ile Thr Gln Leu Gly Leu Gln Asn 
        115                 120                 125             


Ser Thr Ile Thr Phe Trp Asn Ile Thr Leu Glu Asp Glu Gly Cys Tyr 
    130                 135                 140                 


Met Cys Leu Phe Asn Thr Phe Gly Phe Gly Lys Ile Ser Gly Thr Ala 
145                 150                 155                 160 


Cys Leu Thr Val Tyr Val Gln Pro Ile Val Ser Leu His Tyr Lys Phe 
                165                 170                 175     


Ser Glu Asp His Leu Asn Ile Thr Cys Ser Ala Thr Ala Arg Pro Ala 
            180                 185                 190         


Pro Met Val Phe Trp Lys Val Pro Arg Ser Gly Ile Glu Asn Ser Thr 
        195                 200                 205             


Val Thr Leu Ser His Pro Asn Gly Thr Thr Ser Val Thr Ser Ile Leu 
    210                 215                 220                 


His Ile Lys Asp Pro Lys Asn Gln Val Gly Lys Glu Val Ile Cys Gln 
225                 230                 235                 240 


Val Leu His Leu Gly Thr Val Thr Asp Phe Lys Gln Thr Val Asn Lys 
                245                 250                 255     


Gly Tyr Trp Phe Ser Val Pro Leu Leu Leu Ser Ile Val Ser Leu Val 
            260                 265                 270         


Ile Leu Leu Val Leu Ile Ser Ile Leu Leu Tyr Trp Lys Arg His Arg 
        275                 280                 285             


Asn Gln Asp Arg Glu Pro 
    290                 


<210>  6
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Glu Pro 
            260                 265                 


<210>  7
<211>  1786
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Leu Leu Gln Leu Leu Ala Phe Ser Phe Leu Ala Leu Cys Arg 
1               5                   10                  15      


Ala Arg Val Arg Ala Gln Glu Pro Glu Phe Ser Tyr Gly Cys Ala Glu 
            20                  25                  30          


Gly Ser Cys Tyr Pro Ala Thr Gly Asp Leu Leu Ile Gly Arg Ala Gln 
        35                  40                  45              


Lys Leu Ser Val Thr Ser Thr Cys Gly Leu His Lys Pro Glu Pro Tyr 
    50                  55                  60                  


Cys Ile Val Ser His Leu Gln Glu Asp Lys Lys Cys Phe Ile Cys Asn 
65                  70                  75                  80  


Ser Gln Asp Pro Tyr His Glu Thr Leu Asn Pro Asp Ser His Leu Ile 
                85                  90                  95      


Glu Asn Val Val Thr Thr Phe Ala Pro Asn Arg Leu Lys Ile Trp Trp 
            100                 105                 110         


Gln Ser Glu Asn Gly Val Glu Asn Val Thr Ile Gln Leu Asp Leu Glu 
        115                 120                 125             


Ala Glu Phe His Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg 
    130                 135                 140                 


Pro Ala Ala Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp 
145                 150                 155                 160 


Gly Val Tyr Arg Tyr Phe Ala Tyr Asp Cys Glu Ala Ser Phe Pro Gly 
                165                 170                 175     


Ile Ser Thr Gly Pro Met Lys Lys Val Asp Asp Ile Ile Cys Asp Ser 
            180                 185                 190         


Arg Tyr Ser Asp Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Phe Arg 
        195                 200                 205             


Ala Leu Asp Pro Ala Phe Lys Ile Glu Asp Pro Tyr Ser Pro Arg Ile 
    210                 215                 220                 


Gln Asn Leu Leu Lys Ile Thr Asn Leu Arg Ile Lys Phe Val Lys Leu 
225                 230                 235                 240 


His Thr Leu Gly Asp Asn Leu Leu Asp Ser Arg Met Glu Ile Arg Glu 
                245                 250                 255     


Lys Tyr Tyr Tyr Ala Val Tyr Asp Met Val Val Arg Gly Asn Cys Phe 
            260                 265                 270         


Cys Tyr Gly His Ala Ser Glu Cys Ala Pro Val Asp Gly Phe Asn Glu 
        275                 280                 285             


Glu Val Glu Gly Met Val His Gly His Cys Met Cys Arg His Asn Thr 
    290                 295                 300                 


Lys Gly Leu Asn Cys Glu Leu Cys Met Asp Phe Tyr His Asp Leu Pro 
305                 310                 315                 320 


Trp Arg Pro Ala Glu Gly Arg Asn Ser Asn Ala Cys Lys Lys Cys Asn 
                325                 330                 335     


Cys Asn Glu His Ser Ile Ser Cys His Phe Asp Met Ala Val Tyr Leu 
            340                 345                 350         


Ala Thr Gly Asn Val Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn 
        355                 360                 365             


Thr Met Gly Arg Asn Cys Glu Gln Cys Lys Pro Phe Tyr Tyr Gln His 
    370                 375                 380                 


Pro Glu Arg Asp Ile Arg Asp Pro Asn Phe Cys Glu Arg Cys Thr Cys 
385                 390                 395                 400 


Asp Pro Ala Gly Ser Gln Asn Glu Gly Ile Cys Asp Ser Tyr Thr Asp 
                405                 410                 415     


Phe Ser Thr Gly Leu Ile Ala Gly Gln Cys Arg Cys Lys Leu Asn Val 
            420                 425                 430         


Glu Gly Glu His Cys Asp Val Cys Lys Glu Gly Phe Tyr Asp Leu Ser 
        435                 440                 445             


Ser Glu Asp Pro Phe Gly Cys Lys Ser Cys Ala Cys Asn Pro Leu Gly 
    450                 455                 460                 


Thr Ile Pro Gly Gly Asn Pro Cys Asp Ser Glu Thr Gly His Cys Tyr 
465                 470                 475                 480 


Cys Lys Arg Leu Val Thr Gly Gln His Cys Asp Gln Cys Leu Pro Glu 
                485                 490                 495     


His Trp Gly Leu Ser Asn Asp Leu Asp Gly Cys Arg Pro Cys Asp Cys 
            500                 505                 510         


Asp Leu Gly Gly Ala Leu Asn Asn Ser Cys Phe Ala Glu Ser Gly Gln 
        515                 520                 525             


Cys Ser Cys Arg Pro His Met Ile Gly Arg Gln Cys Asn Glu Val Glu 
    530                 535                 540                 


Pro Gly Tyr Tyr Phe Ala Thr Leu Asp His Tyr Leu Tyr Glu Ala Glu 
545                 550                 555                 560 


Glu Ala Asn Leu Gly Pro Gly Val Ser Ile Val Glu Arg Gln Tyr Ile 
                565                 570                 575     


Gln Asp Arg Ile Pro Ser Trp Thr Gly Ala Gly Phe Val Arg Val Pro 
            580                 585                 590         


Glu Gly Ala Tyr Leu Glu Phe Phe Ile Asp Asn Ile Pro Tyr Ser Met 
        595                 600                 605             


Glu Tyr Asp Ile Leu Ile Arg Tyr Glu Pro Gln Leu Pro Asp His Trp 
    610                 615                 620                 


Glu Lys Ala Val Ile Thr Val Gln Arg Pro Gly Arg Ile Pro Thr Ser 
625                 630                 635                 640 


Ser Arg Cys Gly Asn Thr Ile Pro Asp Asp Asp Asn Gln Val Val Ser 
                645                 650                 655     


Leu Ser Pro Gly Ser Arg Tyr Val Val Leu Pro Arg Pro Val Cys Phe 
            660                 665                 670         


Glu Lys Gly Thr Asn Tyr Thr Val Arg Leu Glu Leu Pro Gln Tyr Thr 
        675                 680                 685             


Ser Ser Asp Ser Asp Val Glu Ser Pro Tyr Thr Leu Ile Asp Ser Leu 
    690                 695                 700                 


Val Leu Met Pro Tyr Cys Lys Ser Leu Asp Ile Phe Thr Val Gly Gly 
705                 710                 715                 720 


Ser Gly Asp Gly Val Val Thr Asn Ser Ala Trp Glu Thr Phe Gln Arg 
                725                 730                 735     


Tyr Arg Cys Leu Glu Asn Ser Arg Ser Val Val Lys Thr Pro Met Thr 
            740                 745                 750         


Asp Val Cys Arg Asn Ile Ile Phe Ser Ile Ser Ala Leu Leu His Gln 
        755                 760                 765             


Thr Gly Leu Ala Cys Glu Cys Asp Pro Gln Gly Ser Leu Ser Ser Val 
    770                 775                 780                 


Cys Asp Pro Asn Gly Gly Gln Cys Gln Cys Arg Pro Asn Val Val Gly 
785                 790                 795                 800 


Arg Thr Cys Asn Arg Cys Ala Pro Gly Thr Phe Gly Phe Gly Pro Ser 
                805                 810                 815     


Gly Cys Lys Pro Cys Glu Cys His Leu Gln Gly Ser Val Asn Ala Phe 
            820                 825                 830         


Cys Asn Pro Val Thr Gly Gln Cys His Cys Phe Gln Gly Val Tyr Ala 
        835                 840                 845             


Arg Gln Cys Asp Arg Cys Leu Pro Gly His Trp Gly Phe Pro Ser Cys 
    850                 855                 860                 


Gln Pro Cys Gln Cys Asn Gly His Ala Asp Asp Cys Asp Pro Val Thr 
865                 870                 875                 880 


Gly Glu Cys Leu Asn Cys Gln Asp Tyr Thr Met Gly His Asn Cys Glu 
                885                 890                 895     


Arg Cys Leu Ala Gly Tyr Tyr Gly Asp Pro Ile Ile Gly Ser Gly Asp 
            900                 905                 910         


His Cys Arg Pro Cys Pro Cys Pro Asp Gly Pro Asp Ser Gly Arg Gln 
        915                 920                 925             


Phe Ala Arg Ser Cys Tyr Gln Asp Pro Val Thr Leu Gln Leu Ala Cys 
    930                 935                 940                 


Val Cys Asp Pro Gly Tyr Ile Gly Ser Arg Cys Asp Asp Cys Ala Ser 
945                 950                 955                 960 


Gly Tyr Phe Gly Asn Pro Ser Glu Val Gly Gly Ser Cys Gln Pro Cys 
                965                 970                 975     


Gln Cys His Asn Asn Ile Asp Thr Thr Asp Pro Glu Ala Cys Asp Lys 
            980                 985                 990         


Glu Thr Gly Arg Cys Leu Lys Cys  Leu Tyr His Thr Glu  Gly Glu His 
        995                 1000                 1005             


Cys Gln  Phe Cys Arg Phe Gly  Tyr Tyr Gly Asp Ala  Leu Gln Gln 
    1010                 1015                 1020             


Asp Cys  Arg Lys Cys Val Cys  Asn Tyr Leu Gly Thr  Val Gln Glu 
    1025                 1030                 1035             


His Cys  Asn Gly Ser Asp Cys  Gln Cys Asp Lys Ala  Thr Gly Gln 
    1040                 1045                 1050             


Cys Leu  Cys Leu Pro Asn Val  Ile Gly Gln Asn Cys  Asp Arg Cys 
    1055                 1060                 1065             


Ala Pro  Asn Thr Trp Gln Leu  Ala Ser Gly Thr Gly  Cys Asp Pro 
    1070                 1075                 1080             


Cys Asn  Cys Asn Ala Ala His  Ser Phe Gly Pro Ser  Cys Asn Glu 
    1085                 1090                 1095             


Phe Thr  Gly Gln Cys Gln Cys  Met Pro Gly Phe Gly  Gly Arg Thr 
    1100                 1105                 1110             


Cys Ser  Glu Cys Gln Glu Leu  Phe Trp Gly Asp Pro  Asp Val Glu 
    1115                 1120                 1125             


Cys Arg  Ala Cys Asp Cys Asp  Pro Arg Gly Ile Glu  Thr Pro Gln 
    1130                 1135                 1140             


Cys Asp  Gln Ser Thr Gly Gln  Cys Val Cys Val Glu  Gly Val Glu 
    1145                 1150                 1155             


Gly Pro  Arg Cys Asp Lys Cys  Thr Arg Gly Tyr Ser  Gly Val Phe 
    1160                 1165                 1170             


Pro Asp  Cys Thr Pro Cys His  Gln Cys Phe Ala Leu  Trp Asp Val 
    1175                 1180                 1185             


Ile Ile  Ala Glu Leu Thr Asn  Arg Thr His Arg Phe  Leu Glu Lys 
    1190                 1195                 1200             


Ala Lys  Ala Leu Lys Ile Ser  Gly Val Ile Gly Pro  Tyr Arg Glu 
    1205                 1210                 1215             


Thr Val  Asp Ser Val Glu Arg  Lys Val Ser Glu Ile  Lys Asp Ile 
    1220                 1225                 1230             


Leu Ala  Gln Ser Pro Ala Ala  Glu Pro Leu Lys Asn  Ile Gly Asn 
    1235                 1240                 1245             


Leu Phe  Glu Glu Ala Glu Lys  Leu Ile Lys Asp Val  Thr Glu Met 
    1250                 1255                 1260             


Met Ala  Gln Val Glu Val Lys  Leu Ser Asp Thr Thr  Ser Gln Ser 
    1265                 1270                 1275             


Asn Ser  Thr Ala Lys Glu Leu  Asp Ser Leu Gln Thr  Glu Ala Glu 
    1280                 1285                 1290             


Ser Leu  Asp Asn Thr Val Lys  Glu Leu Ala Glu Gln  Leu Glu Phe 
    1295                 1300                 1305             


Ile Lys  Asn Ser Asp Ile Arg  Gly Ala Leu Asp Ser  Ile Thr Lys 
    1310                 1315                 1320             


Tyr Phe  Gln Met Ser Leu Glu  Ala Glu Glu Arg Val  Asn Ala Ser 
    1325                 1330                 1335             


Thr Thr  Glu Pro Asn Ser Thr  Val Glu Gln Ser Ala  Leu Met Arg 
    1340                 1345                 1350             


Asp Arg  Val Glu Asp Val Met  Met Glu Arg Glu Ser  Gln Phe Lys 
    1355                 1360                 1365             


Glu Lys  Gln Glu Glu Gln Ala  Arg Leu Leu Asp Glu  Leu Ala Gly 
    1370                 1375                 1380             


Lys Leu  Gln Ser Leu Asp Leu  Ser Ala Ala Ala Glu  Met Thr Cys 
    1385                 1390                 1395             


Gly Thr  Pro Pro Gly Ala Ser  Cys Ser Glu Thr Glu  Cys Gly Gly 
    1400                 1405                 1410             


Pro Asn  Cys Arg Thr Asp Glu  Gly Glu Arg Lys Cys  Gly Gly Pro 
    1415                 1420                 1425             


Gly Cys  Gly Gly Leu Val Thr  Val Ala His Asn Ala  Trp Gln Lys 
    1430                 1435                 1440             


Ala Met  Asp Leu Asp Gln Asp  Val Leu Ser Ala Leu  Ala Glu Val 
    1445                 1450                 1455             


Glu Gln  Leu Ser Lys Met Val  Ser Glu Ala Lys Leu  Arg Ala Asp 
    1460                 1465                 1470             


Glu Ala  Lys Gln Ser Ala Glu  Asp Ile Leu Leu Lys  Thr Asn Ala 
    1475                 1480                 1485             


Thr Lys  Glu Lys Met Asp Lys  Ser Asn Glu Glu Leu  Arg Asn Leu 
    1490                 1495                 1500             


Ile Lys  Gln Ile Arg Asn Phe  Leu Thr Gln Asp Ser  Ala Asp Leu 
    1505                 1510                 1515             


Asp Ser  Ile Glu Ala Val Ala  Asn Glu Val Leu Lys  Met Glu Met 
    1520                 1525                 1530             


Pro Ser  Thr Pro Gln Gln Leu  Gln Asn Leu Thr Glu  Asp Ile Arg 
    1535                 1540                 1545             


Glu Arg  Val Glu Ser Leu Ser  Gln Val Glu Val Ile  Leu Gln His 
    1550                 1555                 1560             


Ser Ala  Ala Asp Ile Ala Arg  Ala Glu Met Leu Leu  Glu Glu Ala 
    1565                 1570                 1575             


Lys Arg  Ala Ser Lys Ser Ala  Thr Asp Val Lys Val  Thr Ala Asp 
    1580                 1585                 1590             


Met Val  Lys Glu Ala Leu Glu  Glu Ala Glu Lys Ala  Gln Val Ala 
    1595                 1600                 1605             


Ala Glu  Lys Ala Ile Lys Gln  Ala Asp Glu Asp Ile  Gln Gly Thr 
    1610                 1615                 1620             


Gln Asn  Leu Leu Thr Ser Ile  Glu Ser Glu Thr Ala  Ala Ser Glu 
    1625                 1630                 1635             


Glu Thr  Leu Phe Asn Ala Ser  Gln Arg Ile Ser Glu  Leu Glu Arg 
    1640                 1645                 1650             


Asn Val  Glu Glu Leu Lys Arg  Lys Ala Ala Gln Asn  Ser Gly Glu 
    1655                 1660                 1665             


Ala Glu  Tyr Ile Glu Lys Val  Val Tyr Thr Val Lys  Gln Ser Ala 
    1670                 1675                 1680             


Glu Asp  Val Lys Lys Thr Leu  Asp Gly Glu Leu Asp  Glu Lys Tyr 
    1685                 1690                 1695             


Lys Lys  Val Glu Asn Leu Ile  Ala Lys Lys Thr Glu  Glu Ser Ala 
    1700                 1705                 1710             


Asp Ala  Arg Arg Lys Ala Glu  Met Leu Gln Asn Glu  Ala Lys Thr 
    1715                 1720                 1725             


Leu Leu  Ala Gln Ala Asn Ser  Lys Leu Gln Leu Leu  Lys Asp Leu 
    1730                 1735                 1740             


Glu Arg  Lys Tyr Glu Asp Asn  Gln Arg Tyr Leu Glu  Asp Lys Ala 
    1745                 1750                 1755             


Gln Glu  Leu Ala Arg Leu Glu  Gly Glu Val Arg Ser  Leu Leu Lys 
    1760                 1765                 1770             


Asp Ile  Ser Gln Lys Val Ala  Val Tyr Ser Thr Cys  Leu 
    1775                 1780                 1785     


<210>  8
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Leu Arg Leu Leu Leu Ala Trp Ala Ala Ala Gly Pro Thr Leu 
1               5                   10                  15      


Gly Gln Asp Pro Trp Ala Ala Glu Pro Arg Ala Ala Cys Gly Pro Ser 
            20                  25                  30          


Ser Cys Tyr Ala Leu Phe Pro Arg Arg Arg Thr Phe Leu Glu Ala Trp 
        35                  40                  45              


Arg Ala Cys Arg Glu Leu Gly Gly Asp Leu Ala Thr Pro Arg Thr Pro 
    50                  55                  60                  


Glu Glu Ala Gln Arg Val Asp Ser Leu Val Gly Ala Gly Pro Ala Ser 
65                  70                  75                  80  


Arg Leu Leu Trp Ile Gly Leu Gln Arg Gln Ala Arg Gln Cys Gln Leu 
                85                  90                  95      


Gln Arg Pro Leu Arg Gly Phe Thr Trp Thr Thr Gly Asp Gln Asp Thr 
            100                 105                 110         


Ala Phe Thr Asn Trp Ala Gln Pro Ala Ser Gly Gly Pro Cys Pro Ala 
        115                 120                 125             


Gln Arg Cys Val Ala Leu Glu Ala Ser Gly Glu His Arg Trp Leu Glu 
    130                 135                 140                 


Gly Ser Cys Thr Leu Ala Val Asp Gly Tyr Leu Cys Gln Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Ala Cys Pro Ala Leu Gln Asp Glu Ala Gly Gln Ala Gly Pro 
                165                 170                 175     


Ala Val Tyr Thr Thr Pro Phe His Leu Val Ser Thr Glu Phe Glu Trp 
            180                 185                 190         


Leu Pro Phe Gly Ser Val Ala Ala Val Gln Cys Gln Ala Gly Arg Gly 
        195                 200                 205             


Ala Ser Leu Leu Cys Val Lys Gln Pro Glu Gly Gly Val Gly Trp Ser 
    210                 215                 220                 


Arg Ala Gly Pro Leu Cys Leu Gly Thr Gly Cys Ser Pro Asp Asn Gly 
225                 230                 235                 240 


Gly Cys Glu His Glu Cys Val Glu Glu Val Asp Gly His Val Ser Cys 
                245                 250                 255     


Arg Cys Thr Glu Gly Phe Arg Leu Ala Ala Asp Gly Arg Ser Cys Glu 
            260                 265                 270         


Asp Pro Cys Ala Gln Ala Pro Cys Glu Gln Gln Cys Glu Pro Gly Gly 
        275                 280                 285             


Pro Gln Gly Tyr Ser Cys His Cys Arg Leu Gly Phe Arg Pro Ala Glu 
    290                 295                 300                 


Asp Asp Pro His Arg Cys Val Asp Thr Asp Glu Cys Gln Ile Ala Gly 
305                 310                 315                 320 


Val Cys Gln Gln Met Cys Val Asn Tyr Val Gly Gly Phe Glu Cys Tyr 
                325                 330                 335     


Cys Ser Glu Gly His Glu Leu Glu Ala Asp Gly Ile Ser Cys Ser Pro 
            340                 345                 350         


Ala Gly Ala Met Gly Ala Gln Ala Ser Gln Asp Leu Gly Asp Glu Leu 
        355                 360                 365             


Leu Asp Asp Gly Glu Asp Glu Glu Asp Glu Asp Glu Ala Trp Lys Ala 
    370                 375                 380                 


Phe Asn Gly Gly Trp Thr Glu Met Pro Gly Ile Leu Trp Met Glu Pro 
385                 390                 395                 400 


Thr Gln Pro Pro Asp Phe Ala Leu Ala Tyr Arg Pro Ser Phe Pro Glu 
                405                 410                 415     


Asp Arg Glu Pro Gln Ile Pro Tyr Pro Glu Pro Thr Trp Pro Pro Pro 
            420                 425                 430         


Leu Ser Ala Pro Arg Val Pro Tyr His Ser Ser Val Leu Ser Val Thr 
        435                 440                 445             


Arg Pro Val Val Val Ser Ala Thr His Pro Thr Leu Pro Ser Ala His 
    450                 455                 460                 


Gln Pro Pro Val Ile Pro Ala Thr His Pro Ala Leu Ser Arg Asp His 
465                 470                 475                 480 


Gln Ile Pro Val Ile Ala Ala Asn Tyr Pro Asp Leu Pro Ser Ala Tyr 
                485                 490                 495     


Gln Pro Gly Ile Leu Ser Val Ser His Ser Ala Gln Pro Pro Ala His 
            500                 505                 510         


Gln Pro Pro Met Ile Ser Thr Lys Tyr Pro Glu Leu Phe Pro Ala His 
        515                 520                 525             


Gln Ser Pro Met Phe Pro Asp Thr Arg Val Ala Gly Thr Gln Thr Thr 
    530                 535                 540                 


Thr His Leu Pro Gly Ile Pro Pro Asn His Ala Pro Leu Val Thr Thr 
545                 550                 555                 560 


Leu Gly Ala Gln Leu Pro Pro Gln Ala Pro Asp Ala Leu Val Leu Arg 
                565                 570                 575     


Thr Gln Ala Thr Gln Leu Pro Ile Ile Pro Thr Ala Gln Pro Ser Leu 
            580                 585                 590         


Thr Thr Thr Ser Arg Ser Pro Val Ser Pro Ala His Gln Ile Ser Val 
        595                 600                 605             


Pro Ala Ala Thr Gln Pro Ala Ala Leu Pro Thr Leu Leu Pro Ser Gln 
    610                 615                 620                 


Ser Pro Thr Asn Gln Thr Ser Pro Ile Ser Pro Thr His Pro His Ser 
625                 630                 635                 640 


Lys Ala Pro Gln Ile Pro Arg Glu Asp Gly Pro Ser Pro Lys Leu Ala 
                645                 650                 655     


Leu Trp Leu Pro Ser Pro Ala Pro Thr Ala Ala Pro Thr Ala Leu Gly 
            660                 665                 670         


Glu Ala Gly Leu Ala Glu His Ser Gln Arg Asp Asp Arg Trp Leu Leu 
        675                 680                 685             


Val Ala Leu Leu Val Pro Thr Cys Val Phe Leu Val Val Leu Leu Ala 
    690                 695                 700                 


Leu Gly Ile Val Tyr Cys Thr Arg Cys Gly Pro His Ala Pro Asn Lys 
705                 710                 715                 720 


Arg Ile Thr Asp Cys Tyr Arg Trp Val Ile His Ala Gly Ser Lys Ser 
                725                 730                 735     


Pro Thr Glu Pro Met Pro Pro Arg Gly Ser Leu Thr Gly Val Gln Thr 
            740                 745                 750         


Cys Arg Thr Ser Val 
        755         


<210>  9
<211>  1690
<212>  PRT
<213>  Homo sapiens

<400>  9

Met His Pro Gly Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln Gly 
    50                  55                  60                  


Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Thr 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu Thr 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Thr Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Pro Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser Thr 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Thr Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Thr Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Thr Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Phe Pro Gly Phe Pro  Gly Leu His 
    1160                 1165                 1170             


Gly Leu  Asn Gly Leu Pro Gly  Thr Lys Gly Thr His  Gly Thr Pro 
    1175                 1180                 1185             


Gly Pro  Ser Ile Thr Gly Val  Pro Gly Pro Ala Gly  Leu Pro Gly 
    1190                 1195                 1200             


Pro Lys  Gly Glu Lys Gly Tyr  Pro Gly Ile Gly Ile  Gly Ala Pro 
    1205                 1210                 1215             


Gly Lys  Pro Gly Leu Arg Gly  Gln Lys Gly Asp Arg  Gly Phe Pro 
    1220                 1225                 1230             


Gly Leu  Gln Gly Pro Ala Gly  Leu Pro Gly Ala Pro  Gly Ile Ser 
    1235                 1240                 1245             


Leu Pro  Ser Leu Ile Ala Gly  Gln Pro Gly Asp Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Asp Gly Glu Arg Gly  Arg Pro Gly Pro Ala  Gly Pro Pro 
    1265                 1270                 1275             


Gly Pro  Pro Gly Pro Ser Ser  Asn Gln Gly Asp Thr  Gly Asp Pro 
    1280                 1285                 1290             


Gly Phe  Pro Gly Ile Pro Gly  Pro Lys Gly Pro Lys  Gly Asp Gln 
    1295                 1300                 1305             


Gly Ile  Pro Gly Phe Ser Gly  Leu Pro Gly Glu Leu  Gly Leu Lys 
    1310                 1315                 1320             


Gly Met  Arg Gly Glu Pro Gly  Phe Met Gly Thr Pro  Gly Lys Val 
    1325                 1330                 1335             


Gly Pro  Pro Gly Asp Pro Gly  Phe Pro Gly Met Lys  Gly Lys Ala 
    1340                 1345                 1350             


Gly Pro  Arg Gly Ser Ser Gly  Leu Gln Gly Asp Pro  Gly Gln Thr 
    1355                 1360                 1365             


Pro Thr  Ala Glu Ala Val Gln  Val Pro Pro Gly Pro  Leu Gly Leu 
    1370                 1375                 1380             


Pro Gly  Ile Asp Gly Ile Pro  Gly Leu Thr Gly Asp  Pro Gly Ala 
    1385                 1390                 1395             


Gln Gly  Pro Val Gly Leu Gln  Gly Ser Lys Gly Leu  Pro Gly Ile 
    1400                 1405                 1410             


Pro Gly  Lys Asp Gly Pro Ser  Gly Leu Pro Gly Pro  Pro Gly Ala 
    1415                 1420                 1425             


Leu Gly  Asp Pro Gly Leu Pro  Gly Leu Gln Gly Pro  Pro Gly Phe 
    1430                 1435                 1440             


Glu Gly  Ala Pro Gly Gln Gln  Gly Pro Phe Gly Met  Pro Gly Met 
    1445                 1450                 1455             


Pro Gly  Gln Ser Met Arg Val  Gly Tyr Thr Leu Val  Lys His Ser 
    1460                 1465                 1470             


Gln Ser  Glu Gln Val Pro Pro  Cys Pro Ile Gly Met  Ser Gln Leu 
    1475                 1480                 1485             


Trp Val  Gly Tyr Ser Leu Leu  Phe Val Glu Gly Gln  Glu Lys Ala 
    1490                 1495                 1500             


His Asn  Gln Asp Leu Gly Phe  Ala Gly Ser Cys Leu  Pro Arg Phe 
    1505                 1510                 1515             


Ser Thr  Met Pro Phe Ile Tyr  Cys Asn Ile Asn Glu  Val Cys His 
    1520                 1525                 1530             


Tyr Ala  Arg Arg Asn Asp Lys  Ser Tyr Trp Leu Ser  Thr Thr Ala 
    1535                 1540                 1545             


Pro Ile  Pro Met Met Pro Val  Ser Gln Thr Gln Ile  Pro Gln Tyr 
    1550                 1555                 1560             


Ile Ser  Arg Cys Ser Val Cys  Glu Ala Pro Ser Gln  Ala Ile Ala 
    1565                 1570                 1575             


Val His  Ser Gln Asp Ile Thr  Ile Pro Gln Cys Pro  Leu Gly Trp 
    1580                 1585                 1590             


Arg Ser  Leu Trp Ile Gly Tyr  Ser Phe Leu Met His  Thr Ala Ala 
    1595                 1600                 1605             


Gly Ala  Glu Gly Gly Gly Gln  Ser Leu Val Ser Pro  Gly Ser Cys 
    1610                 1615                 1620             


Leu Glu  Asp Phe Arg Ala Thr  Pro Phe Ile Glu Cys  Ser Gly Ala 
    1625                 1630                 1635             


Arg Gly  Thr Cys His Tyr Phe  Ala Asn Lys Tyr Ser  Phe Trp Leu 
    1640                 1645                 1650             


Thr Thr  Val Glu Glu Arg Gln  Gln Phe Gly Glu Leu  Pro Val Ser 
    1655                 1660                 1665             


Glu Thr  Leu Lys Ala Gly Gln  Leu His Thr Arg Val  Ser Arg Cys 
    1670                 1675                 1680             


Gln Val  Cys Met Lys Ser Leu  
    1685                 1690 


<210>  10
<211>  1691
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Ile Asn Lys Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr 
1               5                   10                  15      


Glu Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly 
            20                  25                  30          


Gly Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala 
        35                  40                  45              


Arg Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln 
    50                  55                  60                  


Gly Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly 
65                  70                  75                  80  


Phe Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro 
                85                  90                  95      


Met Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro 
            100                 105                 110         


Gly Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly 
        115                 120                 125             


Thr Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu 
    130                 135                 140                 


Leu Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro 
145                 150                 155                 160 


Val Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu 
                165                 170                 175     


Pro Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro 
            180                 185                 190         


Gly Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly 
        195                 200                 205             


Pro Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln 
    210                 215                 220                 


Gly Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly 
225                 230                 235                 240 


Pro Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly 
                245                 250                 255     


Lys Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile 
            260                 265                 270         


Ser Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly 
        275                 280                 285             


Glu Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro 
    290                 295                 300                 


Met Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys 
305                 310                 315                 320 


Gly Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly 
                325                 330                 335     


Gln Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile 
            340                 345                 350         


Asp Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly 
        355                 360                 365             


Leu Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro 
    370                 375                 380                 


Ser Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu 
385                 390                 395                 400 


Gly Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly 
                405                 410                 415     


Arg Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro 
            420                 425                 430         


Gly Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu 
        435                 440                 445             


Thr Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln 
    450                 455                 460                 


Gly Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly 
465                 470                 475                 480 


Phe Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu 
                485                 490                 495     


Pro Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys 
            500                 505                 510         


Gly Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly 
        515                 520                 525             


Ala Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys 
    530                 535                 540                 


Lys Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg 
545                 550                 555                 560 


Gly Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly 
                565                 570                 575     


Lys Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp 
            580                 585                 590         


Gly Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly 
        595                 600                 605             


Glu Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro 
    610                 615                 620                 


Gly Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly 
625                 630                 635                 640 


Leu Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Thr Leu Pro 
                645                 650                 655     


Cys Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro 
            660                 665                 670         


Gly Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly 
        675                 680                 685             


Gln Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu 
    690                 695                 700                 


Val His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys 
705                 710                 715                 720 


Gly Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly 
                725                 730                 735     


Met Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp 
            740                 745                 750         


Ile Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly 
        755                 760                 765             


Leu Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu 
    770                 775                 780                 


Lys Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg 
785                 790                 795                 800 


Gly Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly 
                805                 810                 815     


Ser Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala 
            820                 825                 830         


Pro Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg 
        835                 840                 845             


Gly Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly 
    850                 855                 860                 


Leu Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser 
865                 870                 875                 880 


Pro Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys 
                885                 890                 895     


Gly Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly 
            900                 905                 910         


Leu Pro Gly Ile Pro Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser 
        915                 920                 925             


Thr Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys 
    930                 935                 940                 


Gly Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg 
945                 950                 955                 960 


Pro Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser 
                965                 970                 975     


Ala Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala 
            980                 985                 990         


Gly Arg Pro Gly Pro Pro Gly Leu  Pro Gly Ala Pro Gly  Leu Pro Gly 
        995                 1000                 1005             


Ile Ile  Lys Gly Val Ser Gly  Lys Pro Gly Pro Pro  Gly Phe Met 
    1010                 1015                 1020             


Gly Ile  Arg Gly Leu Pro Gly  Leu Lys Gly Ser Ser  Gly Ile Thr 
    1025                 1030                 1035             


Gly Phe  Pro Gly Met Pro Gly  Glu Ser Gly Ser Gln  Gly Ile Arg 
    1040                 1045                 1050             


Gly Ser  Pro Gly Leu Pro Gly  Ala Ser Gly Leu Pro  Gly Leu Lys 
    1055                 1060                 1065             


Gly Asp  Asn Gly Gln Thr Val  Glu Ile Ser Gly Ser  Pro Gly Pro 
    1070                 1075                 1080             


Lys Gly  Gln Pro Gly Glu Ser  Gly Phe Lys Gly Thr  Lys Gly Arg 
    1085                 1090                 1095             


Asp Gly  Leu Ile Gly Asn Ile  Gly Phe Pro Gly Asn  Lys Gly Glu 
    1100                 1105                 1110             


Asp Gly  Lys Val Gly Val Ser  Gly Asp Val Gly Leu  Pro Gly Ala 
    1115                 1120                 1125             


Pro Gly  Phe Pro Gly Val Ala  Gly Met Arg Gly Glu  Pro Gly Leu 
    1130                 1135                 1140             


Pro Gly  Ser Ser Gly His Gln  Gly Ala Ile Gly Pro  Leu Gly Ser 
    1145                 1150                 1155             


Pro Gly  Leu Ile Gly Pro Lys  Gly Phe Pro Gly Phe  Pro Gly Leu 
    1160                 1165                 1170             


His Gly  Leu Asn Gly Leu Pro  Gly Thr Lys Gly Thr  His Gly Thr 
    1175                 1180                 1185             


Pro Gly  Pro Ser Ile Thr Gly  Val Pro Gly Pro Ala  Gly Leu Pro 
    1190                 1195                 1200             


Gly Pro  Lys Gly Glu Lys Gly  Tyr Pro Gly Ile Gly  Ile Gly Ala 
    1205                 1210                 1215             


Pro Gly  Lys Pro Gly Leu Arg  Gly Gln Lys Gly Asp  Arg Gly Phe 
    1220                 1225                 1230             


Pro Gly  Leu Gln Gly Pro Ala  Gly Leu Pro Gly Ala  Pro Gly Ile 
    1235                 1240                 1245             


Ser Leu  Pro Ser Leu Ile Ala  Gly Gln Pro Gly Asp  Pro Gly Arg 
    1250                 1255                 1260             


Pro Gly  Leu Asp Gly Glu Arg  Gly Arg Pro Gly Pro  Ala Gly Pro 
    1265                 1270                 1275             


Pro Gly  Pro Pro Gly Pro Ser  Ser Asn Gln Gly Asp  Thr Gly Asp 
    1280                 1285                 1290             


Pro Gly  Phe Pro Gly Ile Pro  Gly Pro Lys Gly Pro  Lys Gly Asp 
    1295                 1300                 1305             


Gln Gly  Ile Pro Gly Phe Ser  Gly Leu Pro Gly Glu  Leu Gly Leu 
    1310                 1315                 1320             


Lys Gly  Met Arg Gly Glu Pro  Gly Phe Met Gly Thr  Pro Gly Lys 
    1325                 1330                 1335             


Val Gly  Pro Pro Gly Asp Pro  Gly Phe Pro Gly Met  Lys Gly Lys 
    1340                 1345                 1350             


Ala Gly  Pro Arg Gly Ser Ser  Gly Leu Gln Gly Asp  Pro Gly Gln 
    1355                 1360                 1365             


Thr Pro  Thr Ala Glu Ala Val  Gln Val Pro Pro Gly  Pro Leu Gly 
    1370                 1375                 1380             


Leu Pro  Gly Ile Asp Gly Ile  Pro Gly Leu Thr Gly  Asp Pro Gly 
    1385                 1390                 1395             


Ala Gln  Gly Pro Val Gly Leu  Gln Gly Ser Lys Gly  Leu Pro Gly 
    1400                 1405                 1410             


Ile Pro  Gly Lys Asp Gly Pro  Ser Gly Leu Pro Gly  Pro Pro Gly 
    1415                 1420                 1425             


Ala Leu  Gly Asp Pro Gly Leu  Pro Gly Leu Gln Gly  Pro Pro Gly 
    1430                 1435                 1440             


Phe Glu  Gly Ala Pro Gly Gln  Gln Gly Pro Phe Gly  Met Pro Gly 
    1445                 1450                 1455             


Met Pro  Gly Gln Ser Met Arg  Val Gly Tyr Thr Leu  Val Lys His 
    1460                 1465                 1470             


Ser Gln  Ser Glu Gln Val Pro  Pro Cys Pro Ile Gly  Met Ser Gln 
    1475                 1480                 1485             


Leu Trp  Val Gly Tyr Ser Leu  Leu Phe Val Glu Gly  Gln Glu Lys 
    1490                 1495                 1500             


Ala His  Asn Gln Asp Leu Gly  Phe Ala Gly Ser Cys  Leu Pro Arg 
    1505                 1510                 1515             


Phe Ser  Thr Met Pro Phe Ile  Tyr Cys Asn Ile Asn  Glu Val Cys 
    1520                 1525                 1530             


His Tyr  Ala Arg Arg Asn Asp  Lys Ser Tyr Trp Leu  Ser Thr Thr 
    1535                 1540                 1545             


Ala Pro  Ile Pro Met Met Pro  Val Ser Gln Thr Gln  Ile Pro Gln 
    1550                 1555                 1560             


Tyr Ile  Ser Arg Cys Ser Val  Cys Glu Ala Pro Ser  Gln Ala Ile 
    1565                 1570                 1575             


Ala Val  His Ser Gln Asp Ile  Thr Ile Pro Gln Cys  Pro Leu Gly 
    1580                 1585                 1590             


Trp Arg  Ser Leu Trp Ile Gly  Tyr Ser Phe Leu Met  His Thr Ala 
    1595                 1600                 1605             


Ala Gly  Ala Glu Gly Gly Gly  Gln Ser Leu Val Ser  Pro Gly Ser 
    1610                 1615                 1620             


Cys Leu  Glu Asp Phe Arg Ala  Thr Pro Phe Ile Glu  Cys Ser Gly 
    1625                 1630                 1635             


Ala Arg  Gly Thr Cys His Tyr  Phe Ala Asn Lys Tyr  Ser Phe Trp 
    1640                 1645                 1650             


Leu Thr  Thr Val Glu Glu Arg  Gln Gln Phe Gly Glu  Leu Pro Val 
    1655                 1660                 1665             


Ser Glu  Thr Leu Lys Ala Gly  Gln Leu His Thr Arg  Val Ser Arg 
    1670                 1675                 1680             


Cys Gln  Val Cys Met Lys Ser  Leu 
    1685                 1690     


<210>  11
<211>  1072
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Arg Met Arg Thr Ala Gly Trp Ala Arg Gly Trp Cys Leu Gly 
1               5                   10                  15      


Cys Cys Leu Leu Leu Pro Leu Ser Leu Ser Leu Ala Ala Ala Lys Gln 
            20                  25                  30          


Leu Leu Arg Tyr Arg Leu Ala Glu Glu Gly Pro Ala Asp Val Arg Ile 
        35                  40                  45              


Gly Asn Val Ala Ser Asp Leu Gly Ile Val Thr Gly Ser Gly Glu Val 
    50                  55                  60                  


Thr Phe Ser Leu Glu Ser Gly Ser Glu Tyr Leu Lys Ile Asp Asn Leu 
65                  70                  75                  80  


Thr Gly Glu Leu Ser Thr Ser Glu Arg Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Pro Gln Cys Gln Met Ile Phe Asp Glu Asn Glu Cys Phe Leu Asp Phe 
            100                 105                 110         


Glu Val Ser Val Ile Gly Pro Ser Gln Ser Trp Val Asp Leu Phe Glu 
        115                 120                 125             


Gly Gln Val Ile Val Leu Asp Ile Asn Asp Asn Thr Pro Thr Phe Pro 
    130                 135                 140                 


Ser Pro Val Leu Thr Leu Thr Val Glu Glu Asn Arg Pro Val Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Leu Pro Thr Ala Thr Asp Arg Asp Phe Gly Arg Asn Gly 
                165                 170                 175     


Ile Glu Arg Tyr Glu Leu Leu Gln Glu Pro Gly Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Glu Ser Arg Arg Ala Gly Ala Ala Asp Ser Ala Pro Tyr Pro Gly 
        195                 200                 205             


Gly Gly Gly Asn Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Lys Arg 
    210                 215                 220                 


Arg Leu Asp Ala Ser Glu Gly Gly Gly Gly Thr Asn Pro Gly Gly Arg 
225                 230                 235                 240 


Ser Ser Val Phe Glu Leu Gln Val Ala Asp Thr Pro Asp Gly Glu Lys 
                245                 250                 255     


Gln Pro Gln Leu Ile Val Lys Gly Ala Leu Asp Arg Glu Gln Arg Asp 
            260                 265                 270         


Ser Tyr Glu Leu Thr Leu Arg Val Arg Asp Gly Gly Asp Pro Pro Arg 
        275                 280                 285             


Ser Ser Gln Ala Ile Leu Arg Val Leu Ile Thr Asp Val Asn Asp Asn 
    290                 295                 300                 


Ser Pro Arg Phe Glu Lys Ser Val Tyr Glu Ala Asp Leu Ala Glu Asn 
305                 310                 315                 320 


Ser Ala Pro Gly Thr Pro Ile Leu Gln Leu Arg Ala Ala Asp Leu Asp 
                325                 330                 335     


Val Gly Val Asn Gly Gln Ile Glu Tyr Val Phe Gly Ala Ala Thr Glu 
            340                 345                 350         


Ser Val Arg Arg Leu Leu Arg Leu Asp Glu Thr Ser Gly Trp Leu Ser 
        355                 360                 365             


Val Leu His Arg Ile Asp Arg Glu Glu Val Asn Gln Leu Arg Phe Thr 
    370                 375                 380                 


Val Met Ala Arg Asp Arg Gly Gln Pro Pro Lys Thr Asp Lys Ala Thr 
385                 390                 395                 400 


Val Val Leu Asn Ile Lys Asp Glu Asn Asp Asn Val Pro Ser Ile Glu 
                405                 410                 415     


Ile Arg Lys Ile Gly Arg Ile Pro Leu Lys Asp Gly Val Ala Asn Val 
            420                 425                 430         


Ala Glu Asp Val Leu Val Asp Thr Pro Ile Ala Leu Val Gln Val Ser 
        435                 440                 445             


Asp Arg Asp Gln Gly Glu Asn Gly Val Val Thr Cys Thr Val Val Gly 
    450                 455                 460                 


Asp Val Pro Phe Gln Leu Lys Pro Ala Ser Asp Thr Glu Gly Asp Gln 
465                 470                 475                 480 


Asn Lys Lys Lys Tyr Phe Leu His Thr Ser Thr Pro Leu Asp Tyr Glu 
                485                 490                 495     


Ala Thr Arg Glu Phe Asn Val Val Ile Val Ala Val Asp Ser Gly Ser 
            500                 505                 510         


Pro Ser Leu Ser Ser Asn Asn Ser Leu Ile Val Lys Val Gly Asp Thr 
        515                 520                 525             


Asn Asp Asn Pro Pro Met Phe Gly Gln Ser Val Val Glu Val Tyr Phe 
    530                 535                 540                 


Pro Glu Asn Asn Ile Pro Gly Glu Arg Val Ala Thr Val Leu Ala Thr 
545                 550                 555                 560 


Asp Ala Asp Ser Gly Lys Asn Ala Glu Ile Ala Tyr Ser Leu Asp Ser 
                565                 570                 575     


Ser Val Met Gly Ile Phe Ala Ile Asp Pro Asp Ser Gly Asp Ile Leu 
            580                 585                 590         


Val Asn Thr Val Leu Asp Arg Glu Gln Thr Asp Arg Tyr Glu Phe Lys 
        595                 600                 605             


Val Asn Ala Lys Asp Lys Gly Ile Pro Val Leu Gln Gly Ser Thr Thr 
    610                 615                 620                 


Val Ile Val Gln Val Ala Asp Lys Asn Asp Asn Asp Pro Lys Phe Met 
625                 630                 635                 640 


Gln Asp Val Phe Thr Phe Tyr Val Lys Glu Asn Leu Gln Pro Asn Ser 
                645                 650                 655     


Pro Val Gly Met Val Thr Val Met Asp Ala Asp Lys Gly Arg Asn Ala 
            660                 665                 670         


Glu Met Ser Leu Tyr Ile Glu Glu Asn Asn Asn Ile Phe Ser Ile Glu 
        675                 680                 685             


Asn Asp Thr Gly Thr Ile Tyr Ser Thr Met Ser Phe Asp Arg Glu His 
    690                 695                 700                 


Gln Thr Thr Tyr Thr Phe Arg Val Lys Ala Val Asp Gly Gly Asp Pro 
705                 710                 715                 720 


Pro Arg Ser Ala Thr Ala Thr Val Ser Leu Phe Val Met Asp Glu Asn 
                725                 730                 735     


Asp Asn Ala Pro Thr Val Thr Leu Pro Lys Asn Ile Ser Tyr Thr Leu 
            740                 745                 750         


Leu Pro Pro Ser Ser Asn Val Arg Thr Val Val Ala Thr Val Leu Ala 
        755                 760                 765             


Thr Asp Ser Asp Asp Gly Ile Asn Ala Asp Leu Asn Tyr Ser Ile Val 
    770                 775                 780                 


Gly Gly Asn Pro Phe Lys Leu Phe Glu Ile Asp Pro Thr Ser Gly Val 
785                 790                 795                 800 


Val Ser Leu Val Gly Lys Leu Thr Gln Lys His Tyr Gly Leu His Arg 
                805                 810                 815     


Leu Val Val Gln Val Asn Asp Ser Gly Gln Pro Ser Gln Ser Thr Thr 
            820                 825                 830         


Thr Leu Val His Val Phe Val Asn Glu Ser Val Ser Asn Ala Thr Ala 
        835                 840                 845             


Ile Asp Ser Gln Ile Ala Arg Ser Leu His Ile Pro Leu Thr Gln Asp 
    850                 855                 860                 


Ile Ala Gly Asp Pro Ser Tyr Glu Ile Ser Lys Gln Arg Leu Ser Ile 
865                 870                 875                 880 


Val Ile Gly Val Val Ala Gly Ile Met Thr Val Ile Leu Ile Ile Leu 
                885                 890                 895     


Ile Val Val Met Ala Arg Tyr Cys Arg Ser Lys Asn Lys Asn Gly Tyr 
            900                 905                 910         


Glu Ala Gly Lys Lys Asp His Glu Asp Phe Phe Thr Pro Gln Gln His 
        915                 920                 925             


Asp Lys Ser Lys Lys Pro Lys Lys Asp Lys Lys Asn Lys Lys Ser Lys 
    930                 935                 940                 


Gln Pro Leu Tyr Ser Ser Ile Val Thr Val Glu Ala Ser Lys Pro Asn 
945                 950                 955                 960 


Gly Gln Arg Tyr Asp Ser Val Asn Glu Lys Leu Ser Asp Ser Pro Ser 
                965                 970                 975     


Met Gly Arg Tyr Arg Ser Val Asn Gly Gly Pro Gly Ser Pro Asp Leu 
            980                 985                 990         


Ala Arg His Tyr Lys Ser Ser Ser  Pro Leu Pro Thr Val  Gln Leu His 
        995                 1000                 1005             


Pro Gln  Ser Pro Thr Ala Gly  Lys Lys His Gln Ala  Val Gln Asp 
    1010                 1015                 1020             


Leu Pro  Pro Ala Asn Thr Phe  Val Gly Ala Gly Asp  Asn Ile Ser 
    1025                 1030                 1035             


Ile Gly  Ser Asp His Cys Ser  Glu Tyr Ser Cys Gln  Thr Asn Asn 
    1040                 1045                 1050             


Lys Tyr  Ser Lys Gln Val Arg  Cys Ile Pro Asn Ile  Phe Lys Tyr 
    1055                 1060                 1065             


Pro Arg  Glu Gly 
    1070         


<210>  12
<211>  1069
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Arg Met Arg Thr Ala Gly Trp Ala Arg Gly Trp Cys Leu Gly 
1               5                   10                  15      


Cys Cys Leu Leu Leu Pro Leu Ser Leu Ser Leu Ala Ala Ala Lys Gln 
            20                  25                  30          


Leu Leu Arg Tyr Arg Leu Ala Glu Glu Gly Pro Ala Asp Val Arg Ile 
        35                  40                  45              


Gly Asn Val Ala Ser Asp Leu Gly Ile Val Thr Gly Ser Gly Glu Val 
    50                  55                  60                  


Thr Phe Ser Leu Glu Ser Gly Ser Glu Tyr Leu Lys Ile Asp Asn Leu 
65                  70                  75                  80  


Thr Gly Glu Leu Ser Thr Ser Glu Arg Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Pro Gln Cys Gln Met Ile Phe Asp Glu Asn Glu Cys Phe Leu Asp Phe 
            100                 105                 110         


Glu Val Ser Val Ile Gly Pro Ser Gln Ser Trp Val Asp Leu Phe Glu 
        115                 120                 125             


Gly Gln Val Ile Val Leu Asp Ile Asn Asp Asn Thr Pro Thr Phe Pro 
    130                 135                 140                 


Ser Pro Val Leu Thr Leu Thr Val Glu Glu Asn Arg Pro Val Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Leu Pro Thr Ala Thr Asp Arg Asp Phe Gly Arg Asn Gly 
                165                 170                 175     


Ile Glu Arg Tyr Glu Leu Leu Gln Glu Pro Gly Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Glu Ser Arg Arg Ala Gly Ala Ala Asp Ser Ala Pro Tyr Pro Gly 
        195                 200                 205             


Gly Gly Gly Asn Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Lys Arg 
    210                 215                 220                 


Arg Leu Asp Ala Ser Glu Gly Gly Gly Gly Thr Asn Pro Gly Gly Arg 
225                 230                 235                 240 


Ser Ser Val Phe Glu Leu Gln Val Ala Asp Thr Pro Asp Gly Glu Lys 
                245                 250                 255     


Gln Pro Gln Leu Ile Val Lys Gly Ala Leu Asp Arg Glu Gln Arg Asp 
            260                 265                 270         


Ser Tyr Glu Leu Thr Leu Arg Val Arg Asp Gly Gly Asp Pro Pro Arg 
        275                 280                 285             


Ser Ser Gln Ala Ile Leu Arg Val Leu Ile Thr Asp Val Asn Asp Asn 
    290                 295                 300                 


Ser Pro Arg Phe Glu Lys Ser Val Tyr Glu Ala Asp Leu Ala Glu Asn 
305                 310                 315                 320 


Ser Ala Pro Gly Thr Pro Ile Leu Gln Leu Arg Ala Ala Asp Leu Asp 
                325                 330                 335     


Val Gly Val Asn Gly Gln Ile Glu Tyr Val Phe Gly Ala Ala Thr Glu 
            340                 345                 350         


Ser Val Arg Arg Leu Leu Arg Leu Asp Glu Thr Ser Gly Trp Leu Ser 
        355                 360                 365             


Val Leu His Arg Ile Asp Arg Glu Glu Val Asn Gln Leu Arg Phe Thr 
    370                 375                 380                 


Val Met Ala Arg Asp Arg Gly Gln Pro Pro Lys Thr Asp Lys Ala Thr 
385                 390                 395                 400 


Val Val Leu Asn Ile Lys Asp Glu Asn Asp Asn Val Pro Ser Ile Glu 
                405                 410                 415     


Ile Arg Lys Ile Gly Arg Ile Pro Leu Lys Asp Gly Val Ala Asn Val 
            420                 425                 430         


Ala Glu Asp Val Leu Val Asp Thr Pro Ile Ala Leu Val Gln Val Ser 
        435                 440                 445             


Asp Arg Asp Gln Gly Glu Asn Gly Val Val Thr Cys Thr Val Val Gly 
    450                 455                 460                 


Asp Val Pro Phe Gln Leu Lys Pro Ala Ser Asp Thr Glu Gly Asp Gln 
465                 470                 475                 480 


Asn Lys Lys Lys Tyr Phe Leu His Thr Ser Thr Pro Leu Asp Tyr Glu 
                485                 490                 495     


Ala Thr Arg Glu Phe Asn Val Val Ile Val Ala Val Asp Ser Gly Ser 
            500                 505                 510         


Pro Ser Leu Ser Ser Asn Asn Ser Leu Ile Val Lys Val Gly Asp Thr 
        515                 520                 525             


Asn Asp Asn Pro Pro Met Phe Gly Gln Ser Val Val Glu Val Tyr Phe 
    530                 535                 540                 


Pro Glu Asn Asn Ile Pro Gly Glu Arg Val Ala Thr Val Leu Ala Thr 
545                 550                 555                 560 


Asp Ala Asp Ser Gly Lys Asn Ala Glu Ile Ala Tyr Ser Leu Asp Ser 
                565                 570                 575     


Ser Val Met Gly Ile Phe Ala Ile Asp Pro Asp Ser Gly Asp Ile Leu 
            580                 585                 590         


Val Asn Thr Val Leu Asp Arg Glu Gln Thr Asp Arg Tyr Glu Phe Lys 
        595                 600                 605             


Val Asn Ala Lys Asp Lys Gly Ile Pro Val Leu Gln Gly Ser Thr Thr 
    610                 615                 620                 


Val Ile Val Gln Val Ala Asp Lys Asn Asp Asn Asp Pro Lys Phe Met 
625                 630                 635                 640 


Gln Asp Val Phe Thr Phe Tyr Val Lys Glu Asn Leu Gln Pro Asn Ser 
                645                 650                 655     


Pro Val Gly Met Val Thr Val Met Asp Ala Asp Lys Gly Arg Asn Ala 
            660                 665                 670         


Glu Met Ser Leu Tyr Ile Glu Glu Asn Asn Asn Ile Phe Ser Ile Glu 
        675                 680                 685             


Asn Asp Thr Gly Thr Ile Tyr Ser Thr Met Ser Phe Asp Arg Glu His 
    690                 695                 700                 


Gln Thr Thr Tyr Thr Phe Arg Val Lys Ala Val Asp Gly Gly Asp Pro 
705                 710                 715                 720 


Pro Arg Ser Ala Thr Ala Thr Val Ser Leu Phe Val Met Asp Glu Asn 
                725                 730                 735     


Asp Asn Ala Pro Thr Val Thr Leu Pro Lys Asn Ile Ser Tyr Thr Leu 
            740                 745                 750         


Leu Pro Pro Ser Ser Asn Val Arg Thr Val Val Ala Thr Val Leu Ala 
        755                 760                 765             


Thr Asp Ser Asp Asp Gly Ile Asn Ala Asp Leu Asn Tyr Ser Ile Val 
    770                 775                 780                 


Gly Gly Asn Pro Phe Lys Leu Phe Glu Ile Asp Pro Thr Ser Gly Val 
785                 790                 795                 800 


Val Ser Leu Val Gly Lys Leu Thr Gln Lys His Tyr Gly Leu His Arg 
                805                 810                 815     


Leu Val Val Gln Val Asn Asp Ser Gly Gln Pro Ser Gln Ser Thr Thr 
            820                 825                 830         


Thr Leu Val His Val Phe Val Asn Glu Ser Val Ser Asn Ala Thr Ala 
        835                 840                 845             


Ile Asp Ser Gln Ile Ala Arg Ser Leu His Ile Pro Leu Thr Gln Asp 
    850                 855                 860                 


Ile Ala Gly Asp Pro Ser Tyr Glu Ile Ser Lys Gln Arg Leu Ser Ile 
865                 870                 875                 880 


Val Ile Gly Val Val Ala Gly Ile Met Thr Val Ile Leu Ile Ile Leu 
                885                 890                 895     


Ile Val Val Met Ala Arg Tyr Cys Arg Ser Lys Asn Lys Asn Gly Tyr 
            900                 905                 910         


Glu Ala Gly Lys Lys Asp His Glu Asp Phe Phe Thr Pro Gln Gln His 
        915                 920                 925             


Asp Lys Ser Lys Lys Pro Lys Lys Asp Lys Lys Asn Lys Lys Ser Lys 
    930                 935                 940                 


Gln Pro Leu Tyr Ser Ser Ile Val Thr Val Glu Ala Ser Lys Pro Asn 
945                 950                 955                 960 


Gly Gln Arg Tyr Asp Ser Val Asn Glu Lys Leu Ser Asp Ser Pro Ser 
                965                 970                 975     


Met Gly Arg Tyr Arg Ser Val Asn Gly Gly Pro Gly Ser Pro Asp Leu 
            980                 985                 990         


Ala Arg His Tyr Lys Ser Ser Ser  Pro Leu Pro Thr Val  Gln Leu His 
        995                 1000                 1005             


Pro Gln  Ser Pro Thr Ala Gly  Lys Lys His Gln Ala  Val Gln Asp 
    1010                 1015                 1020             


Leu Pro  Pro Ala Asn Thr Phe  Val Gly Ala Gly Asp  Asn Ile Ser 
    1025                 1030                 1035             


Ile Gly  Ser Asp His Cys Ser  Glu Tyr Ser Cys Gln  Thr Asn Asn 
    1040                 1045                 1050             


Lys Tyr  Ser Lys Gln Met Arg  Leu His Pro Tyr Ile  Thr Val Phe 
    1055                 1060                 1065             


Gly 
    


<210>  13
<211>  1247
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Arg Met Arg Thr Ala Gly Trp Ala Arg Gly Trp Cys Leu Gly 
1               5                   10                  15      


Cys Cys Leu Leu Leu Pro Leu Ser Leu Ser Leu Ala Ala Ala Lys Gln 
            20                  25                  30          


Leu Leu Arg Tyr Arg Leu Ala Glu Glu Gly Pro Ala Asp Val Arg Ile 
        35                  40                  45              


Gly Asn Val Ala Ser Asp Leu Gly Ile Val Thr Gly Ser Gly Glu Val 
    50                  55                  60                  


Thr Phe Ser Leu Glu Ser Gly Ser Glu Tyr Leu Lys Ile Asp Asn Leu 
65                  70                  75                  80  


Thr Gly Glu Leu Ser Thr Ser Glu Arg Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Pro Gln Cys Gln Met Ile Phe Asp Glu Asn Glu Cys Phe Leu Asp Phe 
            100                 105                 110         


Glu Val Ser Val Ile Gly Pro Ser Gln Ser Trp Val Asp Leu Phe Glu 
        115                 120                 125             


Gly Gln Val Ile Val Leu Asp Ile Asn Asp Asn Thr Pro Thr Phe Pro 
    130                 135                 140                 


Ser Pro Val Leu Thr Leu Thr Val Glu Glu Asn Arg Pro Val Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Leu Pro Thr Ala Thr Asp Arg Asp Phe Gly Arg Asn Gly 
                165                 170                 175     


Ile Glu Arg Tyr Glu Leu Leu Gln Glu Pro Gly Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Glu Ser Arg Arg Ala Gly Ala Ala Asp Ser Ala Pro Tyr Pro Gly 
        195                 200                 205             


Gly Gly Gly Asn Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Lys Arg 
    210                 215                 220                 


Arg Leu Asp Ala Ser Glu Gly Gly Gly Gly Thr Asn Pro Gly Gly Arg 
225                 230                 235                 240 


Ser Ser Val Phe Glu Leu Gln Val Ala Asp Thr Pro Asp Gly Glu Lys 
                245                 250                 255     


Gln Pro Gln Leu Ile Val Lys Gly Ala Leu Asp Arg Glu Gln Arg Asp 
            260                 265                 270         


Ser Tyr Glu Leu Thr Leu Arg Val Arg Asp Gly Gly Asp Pro Pro Arg 
        275                 280                 285             


Ser Ser Gln Ala Ile Leu Arg Val Leu Ile Thr Asp Val Asn Asp Asn 
    290                 295                 300                 


Ser Pro Arg Phe Glu Lys Ser Val Tyr Glu Ala Asp Leu Ala Glu Asn 
305                 310                 315                 320 


Ser Ala Pro Gly Thr Pro Ile Leu Gln Leu Arg Ala Ala Asp Leu Asp 
                325                 330                 335     


Val Gly Val Asn Gly Gln Ile Glu Tyr Val Phe Gly Ala Ala Thr Glu 
            340                 345                 350         


Ser Val Arg Arg Leu Leu Arg Leu Asp Glu Thr Ser Gly Trp Leu Ser 
        355                 360                 365             


Val Leu His Arg Ile Asp Arg Glu Glu Val Asn Gln Leu Arg Phe Thr 
    370                 375                 380                 


Val Met Ala Arg Asp Arg Gly Gln Pro Pro Lys Thr Asp Lys Ala Thr 
385                 390                 395                 400 


Val Val Leu Asn Ile Lys Asp Glu Asn Asp Asn Val Pro Ser Ile Glu 
                405                 410                 415     


Ile Arg Lys Ile Gly Arg Ile Pro Leu Lys Asp Gly Val Ala Asn Val 
            420                 425                 430         


Ala Glu Asp Val Leu Val Asp Thr Pro Ile Ala Leu Val Gln Val Ser 
        435                 440                 445             


Asp Arg Asp Gln Gly Glu Asn Gly Val Val Thr Cys Thr Val Val Gly 
    450                 455                 460                 


Asp Val Pro Phe Gln Leu Lys Pro Ala Ser Asp Thr Glu Gly Asp Gln 
465                 470                 475                 480 


Asn Lys Lys Lys Tyr Phe Leu His Thr Ser Thr Pro Leu Asp Tyr Glu 
                485                 490                 495     


Ala Thr Arg Glu Phe Asn Val Val Ile Val Ala Val Asp Ser Gly Ser 
            500                 505                 510         


Pro Ser Leu Ser Ser Asn Asn Ser Leu Ile Val Lys Val Gly Asp Thr 
        515                 520                 525             


Asn Asp Asn Pro Pro Met Phe Gly Gln Ser Val Val Glu Val Tyr Phe 
    530                 535                 540                 


Pro Glu Asn Asn Ile Pro Gly Glu Arg Val Ala Thr Val Leu Ala Thr 
545                 550                 555                 560 


Asp Ala Asp Ser Gly Lys Asn Ala Glu Ile Ala Tyr Ser Leu Asp Ser 
                565                 570                 575     


Ser Val Met Gly Ile Phe Ala Ile Asp Pro Asp Ser Gly Asp Ile Leu 
            580                 585                 590         


Val Asn Thr Val Leu Asp Arg Glu Gln Thr Asp Arg Tyr Glu Phe Lys 
        595                 600                 605             


Val Asn Ala Lys Asp Lys Gly Ile Pro Val Leu Gln Gly Ser Thr Thr 
    610                 615                 620                 


Val Ile Val Gln Val Ala Asp Lys Asn Asp Asn Asp Pro Lys Phe Met 
625                 630                 635                 640 


Gln Asp Val Phe Thr Phe Tyr Val Lys Glu Asn Leu Gln Pro Asn Ser 
                645                 650                 655     


Pro Val Gly Met Val Thr Val Met Asp Ala Asp Lys Gly Arg Asn Ala 
            660                 665                 670         


Glu Met Ser Leu Tyr Ile Glu Glu Asn Asn Asn Ile Phe Ser Ile Glu 
        675                 680                 685             


Asn Asp Thr Gly Thr Ile Tyr Ser Thr Met Ser Phe Asp Arg Glu His 
    690                 695                 700                 


Gln Thr Thr Tyr Thr Phe Arg Val Lys Ala Val Asp Gly Gly Asp Pro 
705                 710                 715                 720 


Pro Arg Ser Ala Thr Ala Thr Val Ser Leu Phe Val Met Asp Glu Asn 
                725                 730                 735     


Asp Asn Ala Pro Thr Val Thr Leu Pro Lys Asn Ile Ser Tyr Thr Leu 
            740                 745                 750         


Leu Pro Pro Ser Ser Asn Val Arg Thr Val Val Ala Thr Val Leu Ala 
        755                 760                 765             


Thr Asp Ser Asp Asp Gly Ile Asn Ala Asp Leu Asn Tyr Ser Ile Val 
    770                 775                 780                 


Gly Gly Asn Pro Phe Lys Leu Phe Glu Ile Asp Pro Thr Ser Gly Val 
785                 790                 795                 800 


Val Ser Leu Val Gly Lys Leu Thr Gln Lys His Tyr Gly Leu His Arg 
                805                 810                 815     


Leu Val Val Gln Val Asn Asp Ser Gly Gln Pro Ser Gln Ser Thr Thr 
            820                 825                 830         


Thr Leu Val His Val Phe Val Asn Glu Ser Val Ser Asn Ala Thr Ala 
        835                 840                 845             


Ile Asp Ser Gln Ile Ala Arg Ser Leu His Ile Pro Leu Thr Gln Asp 
    850                 855                 860                 


Ile Ala Gly Asp Pro Ser Tyr Glu Ile Ser Lys Gln Arg Leu Ser Ile 
865                 870                 875                 880 


Val Ile Gly Val Val Ala Gly Ile Met Thr Val Ile Leu Ile Ile Leu 
                885                 890                 895     


Ile Val Val Met Ala Arg Tyr Cys Arg Ser Lys Asn Lys Asn Gly Tyr 
            900                 905                 910         


Glu Ala Gly Lys Lys Asp His Glu Asp Phe Phe Thr Pro Gln Gln His 
        915                 920                 925             


Asp Lys Ser Lys Lys Pro Lys Lys Asp Lys Lys Asn Lys Lys Ser Lys 
    930                 935                 940                 


Gln Pro Leu Tyr Ser Ser Ile Val Thr Val Glu Ala Ser Lys Pro Asn 
945                 950                 955                 960 


Gly Gln Arg Tyr Asp Ser Val Asn Glu Lys Leu Ser Asp Ser Pro Ser 
                965                 970                 975     


Met Gly Arg Tyr Arg Ser Val Asn Gly Gly Pro Gly Ser Pro Asp Leu 
            980                 985                 990         


Ala Arg His Tyr Lys Ser Ser Ser  Pro Leu Pro Thr Val  Gln Leu His 
        995                 1000                 1005             


Pro Gln  Ser Pro Thr Ala Gly  Lys Lys His Gln Ala  Val Gln Asp 
    1010                 1015                 1020             


Leu Pro  Pro Ala Asn Thr Phe  Val Gly Ala Gly Asp  Asn Ile Ser 
    1025                 1030                 1035             


Ile Gly  Ser Asp His Cys Ser  Glu Tyr Ser Cys Gln  Thr Asn Asn 
    1040                 1045                 1050             


Lys Tyr  Ser Lys Gln Pro Phe  Arg Arg Val Thr Phe  Ser Val Val 
    1055                 1060                 1065             


Ser Gln  Pro Gln Asp Pro His  Gln Gly Ser Leu Gln  Ser Cys Tyr 
    1070                 1075                 1080             


Asp Ser  Gly Leu Glu Glu Ser  Glu Thr Pro Ser Ser  Lys Ser Ser 
    1085                 1090                 1095             


Ser Gly  Pro Arg Leu Gly Ala  Leu Pro Leu Pro Glu  Asp Asn Tyr 
    1100                 1105                 1110             


Glu Arg  Thr Thr Pro Asp Gly  Ser Val Asp Ser Arg  Pro Leu Pro 
    1115                 1120                 1125             


Asp Val  Ala Leu Thr Gly Lys  Cys Thr Arg Glu Cys  Asp Glu Tyr 
    1130                 1135                 1140             


Gly His  Ser Asp Ser Cys Trp  Met Pro Val Arg Thr  Ser Pro Glu 
    1145                 1150                 1155             


Arg Lys  Lys Ser Gln Pro Lys  Leu Ser Thr Phe Met  Pro Val Asp 
    1160                 1165                 1170             


Glu Arg  Gly Ser Gln Glu Lys  Leu Ala Asn Gly Glu  Ala Ala Ile 
    1175                 1180                 1185             


Met Gly  Asp Arg Asn Arg Asn  Leu Leu Asn Lys Lys  Leu Thr Ser 
    1190                 1195                 1200             


Ser Tyr  Glu Thr Phe Ser Ala  Ala Ser Phe Ser Lys  Asn Glu Glu 
    1205                 1210                 1215             


Ala Asn  Pro Glu Asp Ile Pro  Leu Thr Lys Thr Gly  Glu Tyr Lys 
    1220                 1225                 1230             


Pro Ser  Pro Val Asn Thr Leu  Thr Arg Arg Glu Val  Tyr Leu 
    1235                 1240                 1245         


<210>  14
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Arg Met Arg Thr Ala Gly Trp Ala Arg Gly Trp Cys Leu Gly 
1               5                   10                  15      


Cys Cys Leu Leu Leu Pro Leu Ser Leu Ser Leu Ala Ala Ala Lys Gln 
            20                  25                  30          


Leu Leu Arg Tyr Arg Leu Ala Glu Glu Gly Pro Ala Asp Val Arg Ile 
        35                  40                  45              


Gly Asn Val Ala Ser Asp Leu Gly Ile Val Thr Gly Ser Gly Glu Val 
    50                  55                  60                  


Thr Phe Ser Leu Glu Ser Gly Ser Glu Tyr Leu Lys Ile Asp Asn Leu 
65                  70                  75                  80  


Thr Gly Glu Leu Ser Thr Ser Glu Arg Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Pro Gln Cys Gln Met Ile Phe Asp Glu Asn Glu Cys Phe Leu Asp Phe 
            100                 105                 110         


Glu Val Ser Val Ile Gly Pro Ser Gln Ser Trp Val Asp Leu Phe Glu 
        115                 120                 125             


Gly Gln Val Ile Val Leu Asp Ile Asn Asp Asn Thr Pro Thr Phe Pro 
    130                 135                 140                 


Ser Pro Val Leu Thr Leu Thr Val Glu Glu Asn Arg Pro Val Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Leu Pro Thr Ala Thr Asp Arg Asp Phe Gly Arg Asn Gly 
                165                 170                 175     


Ile Glu Arg Tyr Glu Leu Leu Gln Glu Pro Gly Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Glu Ser Arg Arg Ala Gly Ala Ala Asp Ser Ala Pro Tyr Pro Gly 
        195                 200                 205             


Gly Gly Gly Asn Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Lys Arg 
    210                 215                 220                 


Arg Leu Asp Ala Ser Glu Gly Gly Gly Gly Thr Asn Pro Gly Gly Arg 
225                 230                 235                 240 


Ser Ser Val Phe Glu Leu Gln Val Ala Asp Thr Pro Asp Gly Glu Lys 
                245                 250                 255     


Gln Pro Gln Leu Ile Val Lys Gly Ala Leu Asp Arg Glu Gln Arg Asp 
            260                 265                 270         


Ser Tyr Glu Leu Thr Leu Arg Val Arg Asp Gly Gly Asp Pro Pro Arg 
        275                 280                 285             


Ser Ser Gln Ala Ile Leu Arg Val Leu Ile Thr Asp Val Asn Asp Asn 
    290                 295                 300                 


Ser Pro Arg Phe Glu Lys Ser Val Tyr Glu Ala Asp Leu Ala Glu Asn 
305                 310                 315                 320 


Ser Ala Pro Gly Thr Pro Ile Leu Gln Leu Arg Ala Ala Asp Leu Asp 
                325                 330                 335     


Val Gly Val Asn Gly Gln Ile Glu Tyr Val Phe Gly Ala Ala Thr Glu 
            340                 345                 350         


Ser Val Arg Arg Leu Leu Arg Leu Asp Glu Thr Ser Gly Trp Leu Ser 
        355                 360                 365             


Val Leu His Arg Ile Asp Arg Glu Glu Val Asn Gln Leu Arg Phe Thr 
    370                 375                 380                 


Val Met Ala Arg Asp Arg Gly Gln Pro Pro Lys Thr Asp Lys Ala Thr 
385                 390                 395                 400 


Val Val Leu Asn Ile Lys Asp Glu Asn Asp Asn Val Pro Ser Ile Glu 
                405                 410                 415     


Ile Arg Lys Ile Gly Arg Ile Pro Leu Lys Asp Gly Val Ala Asn Val 
            420                 425                 430         


Ala Glu Asp Val Leu Val Asp Thr Pro Ile Ala Leu Val Gln Val Ser 
        435                 440                 445             


Asp Arg Asp Gln Gly Glu Asn Gly Val Val Thr Cys Thr Val Val Gly 
    450                 455                 460                 


Asp Val Pro Phe Gln Leu Lys Pro Ala Ser Asp Thr Glu Gly Asp Gln 
465                 470                 475                 480 


Asn Lys Lys Lys Tyr Phe Leu His Thr Ser Thr Pro Leu Asp Tyr Glu 
                485                 490                 495     


Ala Thr Arg Glu Phe Asn Val Val Ile Val Ala Val Asp Ser Gly Ser 
            500                 505                 510         


Pro Ser Leu Ser Ser Asn Asn Ser Leu Ile Val Lys Val Gly Asp Thr 
        515                 520                 525             


Asn Asp Asn Pro Pro Met Phe Gly Gln Ser Val Val Glu Val Tyr Phe 
    530                 535                 540                 


Pro Glu Asn Asn Ile Pro Gly Glu Arg Val Ala Thr Val Leu Ala Thr 
545                 550                 555                 560 


Asp Ala Asp Ser Gly Lys Asn Ala Glu Ile Ala Tyr Ser Leu Asp Ser 
                565                 570                 575     


Ser Val Met Gly Ile Phe Ala Ile Asp Pro Asp Ser Gly Asp Ile Leu 
            580                 585                 590         


Val Asn Thr Val Leu Asp Arg Glu Gln Thr Asp Arg Tyr Glu Phe Lys 
        595                 600                 605             


Val Asn Ala Lys Asp Lys Gly Ile Pro Val Leu Gln Gly Ser Thr Thr 
    610                 615                 620                 


Val Ile Val Gln Val Ala Asp Lys Asn Asp Asn Asp Pro Lys Phe Met 
625                 630                 635                 640 


Gln Asp Val Phe Thr Phe Tyr Val Lys Glu Asn Leu Gln Pro Asn Ser 
                645                 650                 655     


Pro Val Gly Met Val Thr Val Met Asp Ala Asp Lys Gly Arg Asn Ala 
            660                 665                 670         


Glu Met Ser Leu Tyr Ile Glu Glu Asn Asn Asn Ile Phe Ser Ile Glu 
        675                 680                 685             


Asn Asp Thr Gly Thr Ile Tyr Ser Thr Met Ser Phe Asp Arg Glu His 
    690                 695                 700                 


Gln Thr Thr Tyr Thr Phe Arg Val Lys Ala Val Asp Gly Gly Asp Pro 
705                 710                 715                 720 


Pro Arg Ser Ala Thr Ala Thr Val Ser Leu Phe Val Met Asp Glu Asn 
                725                 730                 735     


Asp Asn Ala Pro Thr Val Thr Leu Pro Lys Asn Ile Ser Tyr Thr Leu 
            740                 745                 750         


Leu Pro Pro Ser Ser Asn Val Arg Thr Val Val Ala Thr Val Leu Ala 
        755                 760                 765             


Thr Asp Ser Asp Asp Gly Ile Asn Ala Asp Leu Asn Tyr Ser Ile Val 
    770                 775                 780                 


Gly Gly Asn Pro Phe Lys Leu Phe Glu Ile Asp Pro Thr Ser Gly Val 
785                 790                 795                 800 


Val Ser Leu Val Gly Lys Leu Thr Gln Lys His Tyr Gly Leu His Arg 
                805                 810                 815     


Leu Val Val Gln Val Asn Asp Ser Gly Gln Pro Ser Gln Ser Thr Thr 
            820                 825                 830         


Thr Leu Val His Val Phe Val Asn Glu Ser Val Ser Asn Ala Thr Ala 
        835                 840                 845             


Ile Asp Ser Gln Ile Ala Arg Ser Leu His Ile Pro Leu Thr Gln Asp 
    850                 855                 860                 


Ile Ala Gly Asp Pro Ser Tyr Glu Ile Ser Lys Gln Arg Leu Ser Ile 
865                 870                 875                 880 


Val Ile Gly Val Val Ala Gly Ile Met Thr Val Ile Leu Ile Ile Leu 
                885                 890                 895     


Ile Val Val Met Ala Arg Tyr Cys Arg Ser Lys Asn Lys Asn Gly Tyr 
            900                 905                 910         


Glu Ala Gly Lys Lys Asp His Glu Asp Phe Phe Thr Pro Gln Gln His 
        915                 920                 925             


Asp Lys Ser Lys Lys Pro Lys Lys Asp Lys Lys Asn Lys Lys Ser Lys 
    930                 935                 940                 


Gln Pro Leu Tyr Ser Ser Ile Val Thr Val Glu Ala Ser Lys Pro Asn 
945                 950                 955                 960 


Gly Gln Arg Tyr Asp Ser Val Asn Glu Lys Leu Ser Asp Ser Pro Ser 
                965                 970                 975     


Met Gly Arg Tyr Arg Ser Val Asn Gly Gly Pro Gly Ser Pro Asp Leu 
            980                 985                 990         


Ala Arg His Tyr Lys Ser Ser Ser  Pro Leu Pro Thr Val  Gln Leu His 
        995                 1000                 1005             


Pro Gln  Ser Pro Thr Ala Gly  Lys Lys His Gln Ala  Val Gln Asp 
    1010                 1015                 1020             


Leu Pro  Pro Ala Asn Thr Phe  Val Gly Ala Gly Asp  Asn Ile Ser 
    1025                 1030                 1035             


Ile Gly  Ser Asp His Cys Ser  Glu Tyr Ser Cys Gln  Thr Asn Asn 
    1040                 1045                 1050             


Lys Tyr  Ser Lys Gln Pro Phe  Arg Arg Val Thr Phe  Ser Val Val 
    1055                 1060                 1065             


Ser Gln  Pro Gln Asp Pro His  Gln Gly Ser Leu Gln  Ser Cys Tyr 
    1070                 1075                 1080             


Asp Ser  Gly Leu Glu Glu Ser  Glu Thr Pro Ser Ser  Lys Ser Ser 
    1085                 1090                 1095             


Ser Gly  Pro Arg Leu Gly Ala  Leu Pro Leu Pro Glu  Asp Asn Tyr 
    1100                 1105                 1110             


Glu Arg  Thr Thr Pro Asp Gly  Ser Val Gly Glu Ala  Glu His Met 
    1115                 1120                 1125             


Glu Asn  Asp Ser Arg Pro Leu  Pro Asp Val Ala Leu  Thr Gly Lys 
    1130                 1135                 1140             


Cys Thr  Arg Glu Cys Asp Glu  Tyr Gly His Ser Asp  Ser Cys Trp 
    1145                 1150                 1155             


Met Pro  Val Arg Thr Ser Pro  Glu Arg Lys Lys Ser  Gln Pro Lys 
    1160                 1165                 1170             


Leu Ser  Thr Phe Met Pro Val  Asp Glu Arg Gly Ser  Gln Glu Lys 
    1175                 1180                 1185             


Leu Ala  Asn Gly Glu Ala Ala  Ile Met Gly Asp Arg  Asn Arg Asn 
    1190                 1195                 1200             


Leu Leu  Asn Lys Lys Leu Thr  Ser Ser Tyr Glu Thr  Phe Ser Ala 
    1205                 1210                 1215             


Ala Ser  Phe Ser Lys Asn Glu  Glu Ala Asn Pro Glu  Asp Ile Pro 
    1220                 1225                 1230             


Leu Thr  Lys Thr Gly Glu Tyr  Lys Pro Ser Pro Val  Asn Thr Leu 
    1235                 1240                 1245             


Thr Arg  Arg Glu Val Tyr Leu  
    1250                 1255 


<210>  15
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Glu Arg Cys Pro Ser Leu Gly Val Thr Leu Tyr Ala Leu Val Val 
1               5                   10                  15      


Val Leu Gly Leu Arg Ala Thr Pro Ala Gly Gly Gln His Tyr Leu His 
            20                  25                  30          


Ile Arg Pro Ala Pro Ser Asp Asn Leu Pro Leu Val Asp Leu Ile Glu 
        35                  40                  45              


His Pro Asp Pro Ile Phe Asp Pro Lys Glu Lys Asp Leu Asn Glu Thr 
    50                  55                  60                  


Leu Leu Arg Ser Leu Leu Gly Gly His Tyr Asp Pro Gly Phe Met Ala 
65                  70                  75                  80  


Thr Ser Pro Pro Glu Asp Arg Pro Gly Gly Gly Gly Gly Ala Ala Gly 
                85                  90                  95      


Gly Ala Glu Asp Leu Ala Glu Leu Asp Gln Leu Leu Arg Gln Arg Pro 
            100                 105                 110         


Ser Gly Ala Met Pro Ser Glu Ile Lys Gly Leu Glu Phe Ser Glu Gly 
        115                 120                 125             


Leu Ala Gln Gly Lys Lys Gln Arg Leu Ser Lys Lys Leu Arg Arg Lys 
    130                 135                 140                 


Leu Gln Met Trp Leu Trp Ser Gln Thr Phe Cys Pro Val Leu Tyr Ala 
145                 150                 155                 160 


Trp Asn Asp Leu Gly Ser Arg Phe Trp Pro Arg Tyr Val Lys Val Gly 
                165                 170                 175     


Ser Cys Phe Ser Lys Arg Ser Cys Ser Val Pro Glu Gly Met Val Cys 
            180                 185                 190         


Lys Pro Ser Lys Ser Val His Leu Thr Val Leu Arg Trp Arg Cys Gln 
        195                 200                 205             


Arg Arg Gly Gly Gln Arg Cys Gly Trp Ile Pro Ile Gln Tyr Pro Ile 
    210                 215                 220                 


Ile Ser Glu Cys Lys Cys Ser Cys 
225                 230         


<210>  16
<211>  871
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Tyr Ser Cys Cys Ala Leu Val Leu Ala Val Leu Gly Thr Glu 
1               5                   10                  15      


Leu Leu Gly Ser Leu Cys Ser Thr Val Arg Ser Pro Arg Phe Arg Gly 
            20                  25                  30          


Arg Ile Gln Gln Glu Arg Lys Asn Ile Arg Pro Asn Ile Ile Leu Val 
        35                  40                  45              


Leu Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Leu Gln Val Met Asn 
    50                  55                  60                  


Lys Thr Arg Lys Ile Met Glu His Gly Gly Ala Thr Phe Ile Asn Ala 
65                  70                  75                  80  


Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Met Leu Thr 
                85                  90                  95      


Gly Lys Tyr Val His Asn His Asn Val Tyr Thr Asn Asn Glu Asn Cys 
            100                 105                 110         


Ser Ser Pro Ser Trp Gln Ala Met His Glu Pro Arg Thr Phe Ala Val 
        115                 120                 125             


Tyr Leu Asn Asn Thr Gly Tyr Arg Thr Ala Phe Phe Gly Lys Tyr Leu 
    130                 135                 140                 


Asn Glu Tyr Asn Gly Ser Tyr Ile Pro Pro Gly Trp Arg Glu Trp Leu 
145                 150                 155                 160 


Gly Leu Ile Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Val Cys Arg Asn 
                165                 170                 175     


Gly Ile Lys Glu Lys His Gly Phe Asp Tyr Ala Lys Asp Tyr Phe Thr 
            180                 185                 190         


Asp Leu Ile Thr Asn Glu Ser Ile Asn Tyr Phe Lys Met Ser Lys Arg 
        195                 200                 205             


Met Tyr Pro His Arg Pro Val Met Met Val Ile Ser His Ala Ala Pro 
    210                 215                 220                 


His Gly Pro Glu Asp Ser Ala Pro Gln Phe Ser Lys Leu Tyr Pro Asn 
225                 230                 235                 240 


Ala Ser Gln His Ile Thr Pro Ser Tyr Asn Tyr Ala Pro Asn Met Asp 
                245                 250                 255     


Lys His Trp Ile Met Gln Tyr Thr Gly Pro Met Leu Pro Ile His Met 
            260                 265                 270         


Glu Phe Thr Asn Ile Leu Gln Arg Lys Arg Leu Gln Thr Leu Met Ser 
        275                 280                 285             


Val Asp Asp Ser Val Glu Arg Leu Tyr Asn Met Leu Val Glu Thr Gly 
    290                 295                 300                 


Glu Leu Glu Asn Thr Tyr Ile Ile Tyr Thr Ala Asp His Gly Tyr His 
305                 310                 315                 320 


Ile Gly Gln Phe Gly Leu Val Lys Gly Lys Ser Met Pro Tyr Asp Phe 
                325                 330                 335     


Asp Ile Arg Val Pro Phe Phe Ile Arg Gly Pro Ser Val Glu Pro Gly 
            340                 345                 350         


Ser Ile Val Pro Gln Ile Val Leu Asn Ile Asp Leu Ala Pro Thr Ile 
        355                 360                 365             


Leu Asp Ile Ala Gly Leu Asp Thr Pro Pro Asp Val Asp Gly Lys Ser 
    370                 375                 380                 


Val Leu Lys Leu Leu Asp Pro Glu Lys Pro Gly Asn Arg Phe Arg Thr 
385                 390                 395                 400 


Asn Lys Lys Ala Lys Ile Trp Arg Asp Thr Phe Leu Val Glu Arg Gly 
                405                 410                 415     


Lys Phe Leu Arg Lys Lys Glu Glu Ser Ser Lys Asn Ile Gln Gln Ser 
            420                 425                 430         


Asn His Leu Pro Lys Tyr Glu Arg Val Lys Glu Leu Cys Gln Gln Ala 
        435                 440                 445             


Arg Tyr Gln Thr Ala Cys Glu Gln Pro Gly Gln Lys Trp Gln Cys Ile 
    450                 455                 460                 


Glu Asp Thr Ser Gly Lys Leu Arg Ile His Lys Cys Lys Gly Pro Ser 
465                 470                 475                 480 


Asp Leu Leu Thr Val Arg Gln Ser Thr Arg Asn Leu Tyr Ala Arg Gly 
                485                 490                 495     


Phe His Asp Lys Asp Lys Glu Cys Ser Cys Arg Glu Ser Gly Tyr Arg 
            500                 505                 510         


Ala Ser Arg Ser Gln Arg Lys Ser Gln Arg Gln Phe Leu Arg Asn Gln 
        515                 520                 525             


Gly Thr Pro Lys Tyr Lys Pro Arg Phe Val His Thr Arg Gln Thr Arg 
    530                 535                 540                 


Ser Leu Ser Val Glu Phe Glu Gly Glu Ile Tyr Asp Ile Asn Leu Glu 
545                 550                 555                 560 


Glu Glu Glu Glu Leu Gln Val Leu Gln Pro Arg Asn Ile Ala Lys Arg 
                565                 570                 575     


His Asp Glu Gly His Lys Gly Pro Arg Asp Leu Gln Ala Ser Ser Gly 
            580                 585                 590         


Gly Asn Arg Gly Arg Met Leu Ala Asp Ser Ser Asn Ala Val Gly Pro 
        595                 600                 605             


Pro Thr Thr Val Arg Val Thr His Lys Cys Phe Ile Leu Pro Asn Asp 
    610                 615                 620                 


Ser Ile His Cys Glu Arg Glu Leu Tyr Gln Ser Ala Arg Ala Trp Lys 
625                 630                 635                 640 


Asp His Lys Ala Tyr Ile Asp Lys Glu Ile Glu Ala Leu Gln Asp Lys 
                645                 650                 655     


Ile Lys Asn Leu Arg Glu Val Arg Gly His Leu Lys Arg Arg Lys Pro 
            660                 665                 670         


Glu Glu Cys Ser Cys Ser Lys Gln Ser Tyr Tyr Asn Lys Glu Lys Gly 
        675                 680                 685             


Val Lys Lys Gln Glu Lys Leu Lys Ser His Leu His Pro Phe Lys Glu 
    690                 695                 700                 


Ala Ala Gln Glu Val Asp Ser Lys Leu Gln Leu Phe Lys Glu Asn Asn 
705                 710                 715                 720 


Arg Arg Arg Lys Lys Glu Arg Lys Glu Lys Arg Arg Gln Arg Lys Gly 
                725                 730                 735     


Glu Glu Cys Ser Leu Pro Gly Leu Thr Cys Phe Thr His Asp Asn Asn 
            740                 745                 750         


His Trp Gln Thr Ala Pro Phe Trp Asn Leu Gly Ser Phe Cys Ala Cys 
        755                 760                 765             


Thr Ser Ser Asn Asn Asn Thr Tyr Trp Cys Leu Arg Thr Val Asn Glu 
    770                 775                 780                 


Thr His Asn Phe Leu Phe Cys Glu Phe Ala Thr Gly Phe Leu Glu Tyr 
785                 790                 795                 800 


Phe Asp Met Asn Thr Asp Pro Tyr Gln Leu Thr Asn Thr Val His Thr 
                805                 810                 815     


Val Glu Arg Gly Ile Leu Asn Gln Leu His Val Gln Leu Met Glu Leu 
            820                 825                 830         


Arg Ser Cys Gln Gly Tyr Lys Gln Cys Asn Pro Arg Pro Lys Asn Leu 
        835                 840                 845             


Asp Val Gly Asn Lys Asp Gly Gly Ser Tyr Asp Leu His Arg Gly Gln 
    850                 855                 860                 


Leu Trp Asp Gly Trp Glu Gly 
865                 870     


<210>  17
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg 
        275                 280                 285             


Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr 
    290                 295                 300                 


Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp 
305                 310                 315                 320 


Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr 
                325                 330                 335     


Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser 
            340                 345                 350         


Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro 
        355                 360                 365             


Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile 
    370                 375                 380                 


Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly 
385                 390                 395                 400 


Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr 
                405                 410                 415     


Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp 
            420                 425                 430         


Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys 
        435                 440                 445             


Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala 
    450                 455                 460                 


Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser 
465                 470                 475                 480 


Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp 
                485                 490                 495     


Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly 
            500                 505                 510         


Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu 
        515                 520                 525             


Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile 
    530                 535                 540                 


Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr 
545                 550                 555                 560 


Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro 
                565                 570                 575     


Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe 
            580                 585                 590         


Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu 
        595                 600                 605             


Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser 
    610                 615                 620                 


Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu 
625                 630                 635                 640 


Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp 
                645                 650                 655     


Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp 
            660                 665                 670         


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
        675                 680                 685             


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
    690                 695                 700                 


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
705                 710                 715                 720 


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
                725                 730                 735     


Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser 
            740                 745                 750         


Lys Ser Asn Ser Val Pro Ile Ile Leu Ala Ile Val Gly Leu Met Leu 
        755                 760                 765             


Val Thr Val Val Ala Gly Val Leu Ile Val Lys Lys Tyr Val Cys Gly 
    770                 775                 780                 


Gly Arg Phe Leu Val His Arg Tyr Ser Val Leu Gln Gln His Ala Glu 
785                 790                 795                 800 


Ala Asn Gly Val Asp Gly Val Asp Ala Leu Asp Thr Ala Ser His Thr 
                805                 810                 815     


Asn Lys Ser Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
            820                 825                 830     


<210>  18
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Phe Gly Gln Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys 
1               5                   10                  15      


Asn Phe Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr 
            20                  25                  30          


Glu Phe Gly Met Ala Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu 
        35                  40                  45              


Thr Ala Glu Val Ser Gly Gly Ser Arg Gly Gly Arg Ile Phe Arg Ser 
    50                  55                  60                  


Ser Asp Phe Ala Lys Asn Phe Val Gln Thr Asp Leu Pro Phe His Pro 
65                  70                  75                  80  


Leu Thr Gln Met Met Tyr Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala 
                85                  90                  95      


Leu Ser Thr Glu Asn Gly Leu Trp Val Ser Lys Asn Phe Gly Gly Lys 
            100                 105                 110         


Trp Glu Glu Ile His Lys Ala Val Cys Leu Ala Lys Trp Gly Ser Asp 
        115                 120                 125             


Asn Thr Ile Phe Phe Thr Thr Tyr Ala Asn Gly Ser Cys Thr Asp Leu 
    130                 135                 140                 


Gly Ala Leu Glu Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys 
145                 150                 155                 160 


Thr Ile Gly Val Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu 
                165                 170                 175     


Phe Ala Ser Val Met Ala Asp Lys Asp Thr Thr Arg Arg Ile His Val 
            180                 185                 190         


Ser Thr Asp Gln Gly Asp Thr Trp Ser Met Ala Gln Leu Pro Ser Val 
        195                 200                 205             


Gly Gln Glu Gln Phe Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val 
    210                 215                 220                 


Phe Met His Val Asp Glu Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe 
225                 230                 235                 240 


Thr Ser Asp Asp Arg Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His 
                245                 250                 255     


Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser 
            260                 265                 270         


Leu Arg Gly Val Tyr Ile Thr Ser Val Leu Ser Glu Asp Asn Ser Ile 
        275                 280                 285             


Gln Thr Met Ile Thr Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg 
    290                 295                 300                 


Lys Pro Glu Asn Ser Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu 
305                 310                 315                 320 


Cys Ser Leu His Ile His Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn 
                325                 330                 335     


Val Pro Met Ala Pro Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile 
            340                 345                 350         


Ala His Gly Ser Val Gly Asp Ala Ile Ser Val Met Val Pro Asp Val 
        355                 360                 365             


Tyr Ile Ser Asp Asp Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly 
    370                 375                 380                 


Pro His Tyr Tyr Thr Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Ile 
385                 390                 395                 400 


Glu His Ser Ser Arg Pro Ile Asn Val Ile Lys Phe Ser Thr Asp Glu 
                405                 410                 415     


Gly Gln Cys Trp Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe 
            420                 425                 430         


Thr Gly Leu Ala Ser Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile 
        435                 440                 445             


Trp Gly Phe Thr Glu Ser Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr 
    450                 455                 460                 


Ile Asp Phe Lys Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr 
465                 470                 475                 480 


Thr Ile Trp Leu Ala His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly 
                485                 490                 495     


Cys Ile Leu Gly Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser 
            500                 505                 510         


Val Cys Gln Asn Gly Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile 
        515                 520                 525             


Cys Leu Cys Ser Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg 
    530                 535                 540                 


Pro Glu Asn Asp Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His 
545                 550                 555                 560 


Asp Leu Glu Phe Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn 
                565                 570                 575     


Gly Tyr Arg Lys Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro 
            580                 585                 590         


Val Arg Glu Val Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu 
        595                 600                 605             


Ser Pro Glu Lys Gln Asn Ser Lys Ser Asn Ser Val Pro Ile Ile Leu 
    610                 615                 620                 


Ala Ile Val Gly Leu Met Leu Val Thr Val Val Ala Gly Val Leu Ile 
625                 630                 635                 640 


Val Lys Lys Tyr Val Cys Gly Gly Arg Phe Leu Val His Arg Tyr Ser 
                645                 650                 655     


Val Leu Gln Gln His Ala Glu Ala Asn Gly Val Asp Gly Val Asp Ala 
            660                 665                 670         


Leu Asp Thr Ala Ser His Thr Asn Lys Ser Gly Tyr His Asp Asp Ser 
        675                 680                 685             


Asp Glu Asp Leu Leu Glu 
    690                 


<210>  19
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Arg Gly Lys Ala Lys Glu Glu Gly Ser Trp Lys Lys Phe Ile 
1               5                   10                  15      


Trp Asn Ser Glu Lys Lys Glu Phe Leu Gly Arg Thr Gly Gly Ser Trp 
            20                  25                  30          


Phe Lys Ile Leu Leu Phe Tyr Val Ile Phe Tyr Gly Cys Leu Ala Gly 
        35                  40                  45              


Ile Phe Ile Gly Thr Ile Gln Val Met Leu Leu Thr Ile Ser Glu Phe 
    50                  55                  60                  


Lys Pro Thr Tyr Gln Asp Arg Val Ala Pro Pro Gly Leu Thr Gln Ile 
65                  70                  75                  80  


Pro Gln Ile Gln Lys Thr Glu Ile Ser Phe Arg Pro Asn Asp Pro Lys 
                85                  90                  95      


Ser Tyr Glu Ala Tyr Val Leu Asn Ile Val Arg Phe Leu Glu Lys Tyr 
            100                 105                 110         


Lys Asp Ser Ala Gln Arg Asp Asp Met Ile Phe Glu Asp Cys Gly Asp 
        115                 120                 125             


Val Pro Ser Glu Pro Lys Glu Arg Gly Asp Phe Asn His Glu Arg Gly 
    130                 135                 140                 


Glu Arg Lys Val Cys Arg Phe Lys Leu Glu Trp Leu Gly Asn Cys Ser 
145                 150                 155                 160 


Gly Leu Asn Asp Glu Thr Tyr Gly Tyr Lys Glu Gly Lys Pro Cys Ile 
                165                 170                 175     


Ile Ile Lys Leu Asn Arg Val Leu Gly Phe Lys Pro Lys Pro Pro Lys 
            180                 185                 190         


Asn Glu Ser Leu Glu Thr Tyr Pro Val Met Lys Tyr Asn Pro Asn Val 
        195                 200                 205             


Leu Pro Val Gln Cys Thr Gly Lys Arg Asp Glu Asp Lys Asp Lys Val 
    210                 215                 220                 


Gly Asn Val Glu Tyr Phe Gly Leu Gly Asn Ser Pro Gly Phe Pro Leu 
225                 230                 235                 240 


Gln Tyr Tyr Pro Tyr Tyr Gly Lys Leu Leu Gln Pro Lys Tyr Leu Gln 
                245                 250                 255     


Pro Leu Leu Ala Val Gln Phe Thr Asn Leu Thr Met Asp Thr Glu Ile 
            260                 265                 270         


Arg Ile Glu Cys Lys Ala Tyr Gly Glu Asn Ile Gly Tyr Ser Glu Lys 
        275                 280                 285             


Asp Arg Phe Gln Gly Arg Phe Asp Val Lys Ile Glu Val Lys Ser 
    290                 295                 300             


<210>  20
<211>  2045
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Val Pro His Thr  Val Leu Asn 
    1745                 1750                 1755             


Leu Lys  Glu Pro Leu Tyr Val  Gly Gly Ala Pro Asp  Phe Ser Lys 
    1760                 1765                 1770             


Leu Ala  Arg Ala Ala Ala Val  Ser Ser Gly Phe Asp  Gly Ala Ile 
    1775                 1780                 1785             


Gln Leu  Val Ser Leu Gly Gly  Arg Gln Leu Leu Thr  Pro Glu His 
    1790                 1795                 1800             


Val Leu  Arg Gln Val Asp Val  Thr Ser Phe Ala Gly  His Pro Cys 
    1805                 1810                 1815             


Thr Arg  Ala Ser Gly His Pro  Cys Leu Asn Gly Ala  Ser Cys Val 
    1820                 1825                 1830             


Pro Arg  Glu Ala Ala Tyr Val  Cys Leu Cys Pro Gly  Gly Phe Ser 
    1835                 1840                 1845             


Gly Pro  His Cys Glu Lys Gly  Leu Val Glu Lys Ser  Ala Gly Asp 
    1850                 1855                 1860             


Val Asp  Thr Leu Ala Phe Asp  Gly Arg Thr Phe Val  Glu Tyr Leu 
    1865                 1870                 1875             


Asn Ala  Val Thr Glu Ser Glu  Lys Ala Leu Gln Ser  Asn His Phe 
    1880                 1885                 1890             


Glu Leu  Ser Leu Arg Thr Glu  Ala Thr Gln Gly Leu  Val Leu Trp 
    1895                 1900                 1905             


Ser Gly  Lys Ala Thr Glu Arg  Ala Asp Tyr Val Ala  Leu Ala Ile 
    1910                 1915                 1920             


Val Asp  Gly His Leu Gln Leu  Ser Tyr Asn Leu Gly  Ser Gln Pro 
    1925                 1930                 1935             


Val Val  Leu Arg Ser Thr Val  Pro Val Asn Thr Asn  Arg Trp Leu 
    1940                 1945                 1950             


Arg Val  Val Ala His Arg Glu  Gln Arg Glu Gly Ser  Leu Gln Val 
    1955                 1960                 1965             


Gly Asn  Glu Ala Pro Val Thr  Gly Ser Ser Pro Leu  Gly Ala Thr 
    1970                 1975                 1980             


Gln Leu  Asp Thr Asp Gly Ala  Leu Trp Leu Gly Gly  Leu Pro Glu 
    1985                 1990                 1995             


Leu Pro  Val Gly Pro Ala Leu  Pro Lys Ala Tyr Gly  Thr Gly Phe 
    2000                 2005                 2010             


Val Gly  Cys Leu Arg Asp Val  Val Val Gly Arg His  Pro Leu His 
    2015                 2020                 2025             


Leu Leu  Glu Asp Ala Val Thr  Lys Pro Glu Leu Arg  Pro Cys Pro 
    2030                 2035                 2040             


Thr Pro  
    2045 


<210>  21
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210>  22
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Ile Pro Thr Thr Ala Ala Ser Thr 
            340                 345                 350         


Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp Glu Asn Glu 
        355                 360                 365             


His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg 
    370                 375                 380                 


Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln 
385                 390                 395                 400 


Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe 
                405                 410                 415     


Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln 
            420                 425                 430         


Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu Asn Asp 
        435                 440                 445             


Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln Ala Val 
    450                 455                 460                 


Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr Val Arg 
465                 470                 475                 480 


Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe Glu His Val 
                485                 490                 495     


Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met 
            500                 505                 510         


Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu 
        515                 520                 525             


Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp 
    530                 535                 540                 


Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn 
545                 550                 555                 560 


Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro 
                565                 570                 575     


Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val Asn Gly 
            580                 585                 590         


Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp 
        595                 600                 605             


Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val Asp Ala Arg 
    610                 615                 620                 


Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly Leu Thr 
625                 630                 635                 640 


Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe 
                645                 650                 655     


Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe 
            660                 665                 670         


Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val 
        675                 680                 685             


Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu Val Met Leu 
    690                 695                 700                 


Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val Glu Val Asp 
705                 710                 715                 720 


Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn 
                725                 730                 735     


Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn 
            740                 745                 750     


<210>  23
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Tyr Pro Glu Leu Gln Ile Thr Asn Val Val Glu Ala 
            20                  25                  30          


Asn Gln Pro Val Thr Ile Gln Asn Trp Cys Lys Arg Gly Arg Lys Gln 
        35                  40                  45              


Cys Lys Thr His Pro His Phe Val Ile Pro Tyr Arg Cys Leu Val Gly 
    50                  55                  60                  


Glu Phe Val Ser Asp Ala Leu Leu Val Pro Asp Lys Cys Lys Phe Leu 
65                  70                  75                  80  


His Gln Glu Arg Met Asp Val Cys Glu Thr His Leu His Trp His Thr 
                85                  90                  95      


Val Ala Lys Glu Thr Cys Ser Glu Lys Ser Thr Asn Leu His Asp Tyr 
            100                 105                 110         


Gly Met Leu Leu Pro Cys Gly Ile Asp Lys Phe Arg Gly Val Glu Phe 
        115                 120                 125             


Val Cys Cys Pro Leu Ala Glu Glu Ser Asp Asn Val Asp Ser Ala Asp 
    130                 135                 140                 


Ala Glu Glu Asp Asp Ser Asp Val Trp Trp Gly Gly Ala Asp Thr Asp 
145                 150                 155                 160 


Tyr Ala Asp Gly Ser Glu Asp Lys Val Val Glu Val Ala Glu Glu Glu 
                165                 170                 175     


Glu Val Ala Glu Val Glu Glu Glu Glu Ala Asp Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Gly Asp Glu Val Glu Glu Glu Ala Glu Glu Pro Tyr Glu Glu 
        195                 200                 205             


Ala Thr Glu Arg Thr Thr Ser Ile Ala Thr Thr Thr Thr Thr Thr Thr 
    210                 215                 220                 


Glu Ser Val Glu Glu Val Val Arg Glu Val Cys Ser Glu Gln Ala Glu 
225                 230                 235                 240 


Thr Gly Pro Cys Arg Ala Met Ile Ser Arg Trp Tyr Phe Asp Val Thr 
                245                 250                 255     


Glu Gly Lys Cys Ala Pro Phe Phe Tyr Gly Gly Cys Gly Gly Asn Arg 
            260                 265                 270         


Asn Asn Phe Asp Thr Glu Glu Tyr Cys Met Ala Val Cys Gly Ser Ala 
        275                 280                 285             


Met Ser Gln Ser Leu Leu Lys Thr Thr Gln Glu Pro Leu Ala Arg Asp 
    290                 295                 300                 


Pro Val Lys Leu Pro Thr Thr Ala Ala Ser Thr Pro Asp Ala Val Asp 
305                 310                 315                 320 


Lys Tyr Leu Glu Thr Pro Gly Asp Glu Asn Glu His Ala His Phe Gln 
                325                 330                 335     


Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln 
            340                 345                 350         


Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro 
        355                 360                 365             


Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu 
    370                 375                 380                 


Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Thr 
385                 390                 395                 400 


His Met Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala 
                405                 410                 415     


Leu Glu Asn Tyr Ile Thr Ala Leu Gln Ala Val Pro Pro Arg Pro Arg 
            420                 425                 430         


His Val Phe Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp 
        435                 440                 445             


Arg Gln His Thr Leu Lys His Phe Glu His Val Arg Met Val Asp Pro 
    450                 455                 460                 


Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met Thr His Leu Arg Val 
465                 470                 475                 480 


Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro 
                485                 490                 495     


Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys 
            500                 505                 510         


Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro 
        515                 520                 525             


Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro Ser Leu Thr Glu Thr 
    530                 535                 540                 


Lys Thr Thr Val Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp 
545                 550                 555                 560 


Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn 
                565                 570                 575     


Thr Glu Asn Glu Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg 
            580                 585                 590         


Gly Leu Thr Thr Arg Pro Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu 
        595                 600                 605             


Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly 
    610                 615                 620                 


Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly 
625                 630                 635                 640 


Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile 
                645                 650                 655     


Ala Thr Val Ile Val Ile Thr Leu Val Met Leu Lys Lys Lys Gln Tyr 
            660                 665                 670         


Thr Ser Ile His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro 
        675                 680                 685             


Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro 
    690                 695                 700                 


Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn 
705                 710                 


<210>  24
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Val Pro Thr Thr Ala Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu 
    290                 295                 300                 


Glu Thr Pro Gly Asp Glu Asn Glu His Ala His Phe Gln Lys Ala Lys 
305                 310                 315                 320 


Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln Val Met Arg 
                325                 330                 335     


Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp 
            340                 345                 350         


Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu 
        355                 360                 365             


Gln Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Thr His Met Ala 
    370                 375                 380                 


Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn 
385                 390                 395                 400 


Tyr Ile Thr Ala Leu Gln Ala Val Pro Pro Arg Pro Arg His Val Phe 
                405                 410                 415     


Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His 
            420                 425                 430         


Thr Leu Lys His Phe Glu His Val Arg Met Val Asp Pro Lys Lys Ala 
        435                 440                 445             


Ala Gln Ile Arg Ser Gln Val Met Thr His Leu Arg Val Ile Tyr Glu 
    450                 455                 460                 


Arg Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala 
465                 470                 475                 480 


Glu Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn 
                485                 490                 495     


Tyr Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser 
            500                 505                 510         


Tyr Gly Asn Asp Ala Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr 
        515                 520                 525             


Val Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln 
    530                 535                 540                 


Pro Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn 
545                 550                 555                 560 


Glu Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr 
                565                 570                 575     


Thr Arg Pro Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser 
            580                 585                 590         


Glu Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val 
        595                 600                 605             


His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys 
    610                 615                 620                 


Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val 
625                 630                 635                 640 


Ile Val Ile Thr Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile 
                645                 650                 655     


His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg 
            660                 665                 670         


His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys 
        675                 680                 685             


Phe Phe Glu Gln Met Gln Asn 
    690                 695 


<210>  25
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Tyr Pro Glu Leu Gln Ile Thr Asn Val Val Glu Ala 
            20                  25                  30          


Asn Gln Pro Val Thr Ile Gln Asn Trp Cys Lys Arg Gly Arg Lys Gln 
        35                  40                  45              


Cys Lys Thr His Pro His Phe Val Ile Pro Tyr Arg Cys Leu Val Gly 
    50                  55                  60                  


Glu Phe Val Ser Asp Ala Leu Leu Val Pro Asp Lys Cys Lys Phe Leu 
65                  70                  75                  80  


His Gln Glu Arg Met Asp Val Cys Glu Thr His Leu His Trp His Thr 
                85                  90                  95      


Val Ala Lys Glu Thr Cys Ser Glu Lys Ser Thr Asn Leu His Asp Tyr 
            100                 105                 110         


Gly Met Leu Leu Pro Cys Gly Ile Asp Lys Phe Arg Gly Val Glu Phe 
        115                 120                 125             


Val Cys Cys Pro Leu Ala Glu Glu Ser Asp Asn Val Asp Ser Ala Asp 
    130                 135                 140                 


Ala Glu Glu Asp Asp Ser Asp Val Trp Trp Gly Gly Ala Asp Thr Asp 
145                 150                 155                 160 


Tyr Ala Asp Gly Ser Glu Asp Lys Val Val Glu Val Ala Glu Glu Glu 
                165                 170                 175     


Glu Val Ala Glu Val Glu Glu Glu Glu Ala Asp Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Gly Asp Glu Val Glu Glu Glu Ala Glu Glu Pro Tyr Glu Glu 
        195                 200                 205             


Ala Thr Glu Arg Thr Thr Ser Ile Ala Thr Thr Thr Thr Thr Thr Thr 
    210                 215                 220                 


Glu Ser Val Glu Glu Val Val Arg Val Pro Thr Thr Ala Ala Ser Thr 
225                 230                 235                 240 


Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp Glu Asn Glu 
                245                 250                 255     


His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg 
            260                 265                 270         


Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln 
        275                 280                 285             


Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe 
    290                 295                 300                 


Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln 
305                 310                 315                 320 


Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu Asn Asp 
                325                 330                 335     


Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln Ala Val 
            340                 345                 350         


Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr Val Arg 
        355                 360                 365             


Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe Glu His Val 
    370                 375                 380                 


Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met 
385                 390                 395                 400 


Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu 
                405                 410                 415     


Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp 
            420                 425                 430         


Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn 
        435                 440                 445             


Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro 
    450                 455                 460                 


Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val Asn Gly 
465                 470                 475                 480 


Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp 
                485                 490                 495     


Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val Asp Ala Arg 
            500                 505                 510         


Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly Leu Thr 
        515                 520                 525             


Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe 
    530                 535                 540                 


Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe 
545                 550                 555                 560 


Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val 
                565                 570                 575     


Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu Val Met Leu 
            580                 585                 590         


Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val Glu Val Asp 
        595                 600                 605             


Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn 
    610                 615                 620                 


Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn 
625                 630                 635                 


<210>  26
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210>  27
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser 
    690                 695                 700                 


Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly Ile Leu Ile Val 
705                 710                 715                 720 


Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr Cys Tyr Phe Leu 
                725                 730                 735     


Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn Leu Cys Gly Lys 
            740                 745                 750         


Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu Gly Lys Ala Ala 
        755                 760                 765             


Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu Val Arg Thr Glu 
    770                 775                 780                 


Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His Thr Glu Pro Asn 
785                 790                 795                 800 


Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro Val Glu Ala Lys 
                805                 810                 815     


Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro Ala Glu Val Lys 
            820                 825                 830         


Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
        835                 840                 845             


<210>  28
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val His Ser Pro Pro Pro Pro Ala Ser Ala Ser 
        595                 600                 605             


Ser Ser Thr Pro Val Pro Leu Ser Pro Pro Asp Thr Thr Trp Pro Leu 
    610                 615                 620                 


Pro Ala Leu Ala Thr Thr Glu Pro Ala Lys Gly Glu Pro Ser Ala Pro 
625                 630                 635                 640 


Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn 
                645                 650                 655     


Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val 
            660                 665                 670         


Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro 
        675                 680                 685             


Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu 
    690                 695                 700                 


Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala 
705                 710                 715                 720 


Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala 
                725                 730                 735     


Thr Leu Gly Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe 
            740                 745                 750         


Ser Ala Val Thr Leu Leu Leu Leu Cys 
        755                 760     


<210>  29
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 
        355                 360                 365             


Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 
    370                 375                 380                 


Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 
385                 390                 395                 400 


Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 
                405                 410                 415     


Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 
            420                 425                 430         


Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 
        435                 440                 445             


Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 
    450                 455                 460                 


Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 
465                 470                 475                 480 


Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 
                485                 490                 495     


Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 
            500                 505                 510         


Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 
        515                 520                 525             


Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 
    530                 535                 540                 


Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 
545                 550                 555                 560 


Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 
                565                 570                 575     


Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 
            580                 585                 590         


Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 
        595                 600                 605             


Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 
    610                 615                 620                 


Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 
625                 630                 635                 640 


Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 
                645                 650                 655     


Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 
            660                 665                 670         


Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 
        675                 680                 685             


Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 
    690                 695                 700                 


Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 
705                 710                 715                 720 


Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 
                725                 730                 735     


Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 
            740                 745                 750         


Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 
        755                 760                 765             


Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 
    770                 775                 780                 


Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 
785                 790                 795                 800 


His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 
                805                 810                 815     


Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 
            820                 825                 830         


Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 
        835                 840                 845             


Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 
    850                 855             


<210>  30
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Thr Leu Asp Gly His Met Val Val Arg Ser His Ala Arg Val Ser 
        355                 360                 365             


Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile 
    370                 375                 380                 


Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu 
385                 390                 395                 400 


Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val Ala Val Tyr Thr 
                405                 410                 415     


Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro 
            420                 425                 430         


Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser 
        435                 440                 445             


Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu 
    450                 455                 460                 


Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr 
465                 470                 475                 480 


Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe Ile Leu Val Gln 
                485                 490                 495     


Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser 
            500                 505                 510         


Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala Thr Gly Gly Val 
        515                 520                 525             


Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val Gly Glu Glu Val 
    530                 535                 540                 


Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser Met Glu Gly Ile 
545                 550                 555                 560 


Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu 
                565                 570                 575     


Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu 
            580                 585                 590         


Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu 
        595                 600                 605             


Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val Asn Leu Ile Lys 
    610                 615                 620                 


Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu Val Arg Tyr Arg 
625                 630                 635                 640 


Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser 
                645                 650                 655     


Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val 
            660                 665                 670         


Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys Ala Ala His Phe 
        675                 680                 685             


Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro Ala Thr Leu Gly 
    690                 695                 700                 


Gly Asn Ser Ala Ser Tyr Thr Phe Val Ser Leu Leu Phe Ser Ala Val 
705                 710                 715                 720 


Thr Leu Leu Leu Leu Cys 
                725     


<210>  31
<211>  884
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 
                165                 170                 175     


Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 
                325                 330                 335     


Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 
            340                 345                 350         


Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Val His Ala Pro Trp 
        355                 360                 365             


Asn Trp Gln Val Gly Arg Gln Lys Gly Gln Ala Gly Ser Ala Gly Phe 
    370                 375                 380                 


Pro Gly Ser His Glu Thr Leu Asp Gly His Met Val Val Arg Ser His 
385                 390                 395                 400 


Ala Arg Val Ser Ser Leu Thr Leu Lys Ser Ile Gln Tyr Thr Asp Ala 
                405                 410                 415     


Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr Ile Gly Gln Asp Ser Gln 
            420                 425                 430         


Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro Lys Leu Gln Gly Pro Val 
        435                 440                 445             


Ala Val Tyr Thr Trp Glu Gly Asn Gln Val Asn Ile Thr Cys Glu Val 
    450                 455                 460                 


Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp Phe Arg Asp Gly Gln Leu 
465                 470                 475                 480 


Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys Ile Tyr Asn Thr Pro Ser 
                485                 490                 495     


Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser Glu Asn Asp Phe Gly Asn 
            500                 505                 510         


Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly Gln Glu Ser Leu Glu Phe 
        515                 520                 525             


Ile Leu Val Gln Ala Asp Thr Pro Ser Ser Pro Ser Ile Asp Gln Val 
    530                 535                 540                 


Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln Phe Asp Glu Pro Glu Ala 
545                 550                 555                 560 


Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys Ala Glu Trp Arg Ala Val 
                565                 570                 575     


Gly Glu Glu Val Trp His Ser Lys Trp Tyr Asp Ala Lys Glu Ala Ser 
            580                 585                 590         


Met Glu Gly Ile Val Thr Ile Val Gly Leu Lys Pro Glu Thr Thr Tyr 
        595                 600                 605             


Ala Val Arg Leu Ala Ala Leu Asn Gly Lys Gly Leu Gly Glu Ile Ser 
    610                 615                 620                 


Ala Ala Ser Glu Phe Lys Thr Gln Pro Val Gln Gly Glu Pro Ser Ala 
625                 630                 635                 640 


Pro Lys Leu Glu Gly Gln Met Gly Glu Asp Gly Asn Ser Ile Lys Val 
                645                 650                 655     


Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser Pro Ile Arg His Tyr Leu 
            660                 665                 670         


Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp Lys Pro Glu Ile Arg Leu 
        675                 680                 685             


Pro Ser Gly Ser Asp His Val Met Leu Lys Ser Leu Asp Trp Asn Ala 
    690                 695                 700                 


Glu Tyr Glu Val Tyr Val Val Ala Glu Asn Gln Gln Gly Lys Ser Lys 
705                 710                 715                 720 


Ala Ala His Phe Val Phe Arg Thr Ser Ala Gln Pro Thr Ala Ile Pro 
                725                 730                 735     


Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser Thr Gly Ala Ile Val Gly 
            740                 745                 750         


Ile Leu Ile Val Ile Phe Val Leu Leu Leu Val Val Val Asp Ile Thr 
        755                 760                 765             


Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe Met Cys Ile Ala Val Asn 
    770                 775                 780                 


Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys Gly Lys Asp Met Glu Glu 
785                 790                 795                 800 


Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser Lys Glu Pro Ile Val Glu 
                805                 810                 815     


Val Arg Thr Glu Glu Glu Arg Thr Pro Asn His Asp Gly Gly Lys His 
            820                 825                 830         


Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr Glu Pro Glu Lys Gly Pro 
        835                 840                 845             


Val Glu Ala Lys Pro Glu Cys Gln Glu Thr Glu Thr Lys Pro Ala Pro 
    850                 855                 860                 


Ala Glu Val Lys Thr Val Pro Asn Asp Ala Thr Gln Thr Lys Glu Asn 
865                 870                 875                 880 


Glu Ser Lys Ala 
                


<210>  32
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Val Asp Ile 
                805                 810                 815     


Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu 
            820                 825                 830         


Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly 
        835                 840                 845             


Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro 
    850                 855                 860                 


Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly 
865                 870                 875                 880 


Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly 
                885                 890                 895     


Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu 
            900                 905                 910         


Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn His Gln Lys Cys Cys 
        915                 920                 925             


Ser Glu Ala 
    930     


<210>  33
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Val Asp Ile Pro Glu Ile His Glu 
                805                 810                 815     


Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp 
            820                 825                 830         


Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp 
        835                 840                 845             


Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile 
    850                 855                 860                 


Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly 
865                 870                 875                 880 


Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser 
                885                 890                 895     


Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys 
            900                 905                 910         


His Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
        915                 920                 925     


<210>  34
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Asp Glu Tyr Glu Val Asp Trp Ser 
                805                 810                 815     


Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys 
            820                 825                 830         


Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile 
        835                 840                 845             


Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly Leu 
    850                 855                 860                 


Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser Cys 
865                 870                 875                 880 


Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys His 
                885                 890                 895     


Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
            900                 905                 


<210>  35
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Gly Gly Thr 
                805                 810                 815     


Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro 
            820                 825                 830         


Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu 
        835                 840                 845             


Val Leu Val Ser Val Ala Leu Ala Leu Val Leu His Tyr His Arg Phe 
    850                 855                 860                 


Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser 
865                 870                 875                 880 


His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile 
                885                 890                 895     


Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
            900                 905     


<210>  36
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Gly Thr Leu Leu Pro Gly Thr 
                805                 810                 815     


Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro Ile Pro Ala Tyr Trp 
            820                 825                 830         


Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu Val Leu Val Ser Val 
        835                 840                 845             


Ala Leu Ala Leu Val Leu His Tyr His Arg Phe Arg Tyr Ala Ala Lys 
    850                 855                 860                 


Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser His Tyr Thr Asn Gly 
865                 870                 875                 880 


Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile Lys Leu Glu Gln Asp 
                885                 890                 895     


Arg Gly Ser His Cys 
            900     


<210>  37
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Val Gly Cys Ser Trp Arg Pro Leu 
545                 550                 555 


<210>  38
<211>  1894
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Glu Gln Arg Arg Pro Trp Pro Arg Ala Leu Glu Val Asp Ser Arg 
1               5                   10                  15      


Ser Val Val Leu Leu Ser Val Val Trp Val Leu Leu Ala Pro Pro Ala 
            20                  25                  30          


Ala Gly Met Pro Gln Phe Ser Thr Phe His Ser Glu Asn Arg Asp Trp 
        35                  40                  45              


Thr Phe Asn His Leu Thr Val His Gln Gly Thr Gly Ala Val Tyr Val 
    50                  55                  60                  


Gly Ala Ile Asn Arg Val Tyr Lys Leu Thr Gly Asn Leu Thr Ile Gln 
65                  70                  75                  80  


Val Ala His Lys Thr Gly Pro Glu Glu Asp Asn Lys Ser Cys Tyr Pro 
                85                  90                  95      


Pro Leu Ile Val Gln Pro Cys Ser Glu Val Leu Thr Leu Thr Asn Asn 
            100                 105                 110         


Val Asn Lys Leu Leu Ile Ile Asp Tyr Ser Glu Asn Arg Leu Leu Ala 
        115                 120                 125             


Cys Gly Ser Leu Tyr Gln Gly Val Cys Lys Leu Leu Arg Leu Asp Asp 
    130                 135                 140                 


Leu Phe Ile Leu Val Glu Pro Ser His Lys Lys Glu His Tyr Leu Ser 
145                 150                 155                 160 


Ser Val Asn Lys Thr Gly Thr Met Tyr Gly Val Ile Val Arg Ser Glu 
                165                 170                 175     


Gly Glu Asp Gly Lys Leu Phe Ile Gly Thr Ala Val Asp Gly Lys Gln 
            180                 185                 190         


Asp Tyr Phe Pro Thr Leu Ser Ser Arg Lys Leu Pro Arg Asp Pro Glu 
        195                 200                 205             


Ser Ser Ala Met Leu Asp Tyr Glu Leu His Ser Asp Phe Val Ser Ser 
    210                 215                 220                 


Leu Ile Lys Ile Pro Ser Asp Thr Leu Ala Leu Val Ser His Phe Asp 
225                 230                 235                 240 


Ile Phe Tyr Ile Tyr Gly Phe Ala Ser Gly Gly Phe Val Tyr Phe Leu 
                245                 250                 255     


Thr Val Gln Pro Glu Thr Pro Glu Gly Val Ala Ile Asn Ser Ala Gly 
            260                 265                 270         


Asp Leu Phe Tyr Thr Ser Arg Ile Val Arg Leu Cys Lys Asp Asp Pro 
        275                 280                 285             


Lys Phe His Ser Tyr Val Ser Leu Pro Phe Gly Cys Thr Arg Ala Gly 
    290                 295                 300                 


Val Glu Tyr Arg Leu Leu Gln Ala Ala Tyr Leu Ala Lys Pro Gly Asp 
305                 310                 315                 320 


Ser Leu Ala Gln Ala Phe Asn Ile Thr Ser Gln Asp Asp Val Leu Phe 
                325                 330                 335     


Ala Ile Phe Ser Lys Gly Gln Lys Gln Tyr His His Pro Pro Asp Asp 
            340                 345                 350         


Ser Ala Leu Cys Ala Phe Pro Ile Arg Ala Ile Asn Leu Gln Ile Lys 
        355                 360                 365             


Glu Arg Leu Gln Ser Cys Tyr Gln Gly Glu Gly Asn Leu Glu Leu Asn 
    370                 375                 380                 


Trp Leu Leu Gly Lys Asp Val Gln Cys Thr Lys Ala Pro Val Pro Ile 
385                 390                 395                 400 


Asp Asp Asn Phe Cys Gly Leu Asp Ile Asn Gln Pro Leu Gly Gly Ser 
                405                 410                 415     


Thr Pro Val Glu Gly Leu Thr Leu Tyr Thr Thr Ser Arg Asp Arg Met 
            420                 425                 430         


Thr Ser Val Ala Ser Tyr Val Tyr Asn Gly Tyr Ser Val Val Phe Val 
        435                 440                 445             


Gly Thr Lys Ser Gly Lys Leu Lys Lys Ile Arg Ala Asp Gly Pro Pro 
    450                 455                 460                 


His Gly Gly Val Gln Tyr Glu Met Val Ser Val Leu Lys Asp Gly Ser 
465                 470                 475                 480 


Pro Ile Leu Arg Asp Met Ala Phe Ser Ile Asp Gln Arg Tyr Leu Tyr 
                485                 490                 495     


Val Met Ser Glu Arg Gln Val Thr Arg Val Pro Val Glu Ser Cys Glu 
            500                 505                 510         


Gln Tyr Thr Thr Cys Gly Glu Cys Leu Ser Ser Gly Asp Pro His Cys 
        515                 520                 525             


Gly Trp Cys Ala Leu His Asn Met Cys Ser Arg Arg Asp Lys Cys Gln 
    530                 535                 540                 


Gln Ala Trp Glu Pro Asn Arg Phe Ala Ala Ser Ile Ser Gln Cys Val 
545                 550                 555                 560 


Ser Leu Ala Val His Pro Ser Ser Ile Ser Val Ser Glu His Ser Arg 
                565                 570                 575     


Leu Leu Ser Leu Val Val Ser Asp Ala Pro Asp Leu Ser Ala Gly Ile 
            580                 585                 590         


Ala Cys Ala Phe Gly Asn Leu Thr Glu Val Glu Gly Gln Val Ser Gly 
        595                 600                 605             


Ser Gln Val Ile Cys Ile Ser Pro Gly Pro Lys Asp Val Pro Val Ile 
    610                 615                 620                 


Pro Leu Asp Gln Asp Trp Phe Gly Leu Glu Leu Gln Leu Arg Ser Lys 
625                 630                 635                 640 


Glu Thr Gly Lys Ile Phe Val Ser Thr Glu Phe Lys Phe Tyr Asn Cys 
                645                 650                 655     


Ser Ala His Gln Leu Cys Leu Ser Cys Val Asn Ser Ala Phe Arg Cys 
            660                 665                 670         


His Trp Cys Lys Tyr Arg Asn Leu Cys Thr His Asp Pro Thr Thr Cys 
        675                 680                 685             


Ser Phe Gln Glu Gly Arg Ile Asn Ile Ser Glu Asp Cys Pro Gln Leu 
    690                 695                 700                 


Val Pro Thr Glu Glu Ile Leu Ile Pro Val Gly Glu Val Lys Pro Ile 
705                 710                 715                 720 


Thr Leu Lys Ala Arg Asn Leu Pro Gln Pro Gln Ser Gly Gln Arg Gly 
                725                 730                 735     


Tyr Glu Cys Val Leu Asn Ile Gln Gly Ala Ile His Arg Val Pro Ala 
            740                 745                 750         


Leu Arg Phe Asn Ser Ser Ser Val Gln Cys Gln Asn Ser Ser Tyr Gln 
        755                 760                 765             


Tyr Asp Gly Met Asp Ile Ser Asn Leu Ala Val Asp Phe Ala Val Val 
    770                 775                 780                 


Trp Asn Gly Asn Phe Ile Ile Asp Asn Pro Gln Asp Leu Lys Val His 
785                 790                 795                 800 


Leu Tyr Lys Cys Ala Ala Gln Arg Glu Ser Cys Gly Leu Cys Leu Lys 
                805                 810                 815     


Ala Asp Arg Lys Phe Glu Cys Gly Trp Cys Ser Gly Glu Arg Arg Cys 
            820                 825                 830         


Thr Leu His Gln His Cys Thr Ser Pro Ser Ser Pro Trp Leu Asp Trp 
        835                 840                 845             


Ser Ser His Asn Val Lys Cys Ser Asn Pro Gln Ile Thr Glu Ile Leu 
    850                 855                 860                 


Thr Val Ser Gly Pro Pro Glu Gly Gly Thr Arg Val Thr Ile His Gly 
865                 870                 875                 880 


Val Asn Leu Gly Leu Asp Phe Ser Glu Ile Ala His His Val Gln Val 
                885                 890                 895     


Ala Gly Val Pro Cys Thr Pro Leu Pro Gly Glu Tyr Ile Ile Ala Glu 
            900                 905                 910         


Gln Ile Val Cys Glu Met Gly His Ala Leu Val Gly Thr Thr Ser Gly 
        915                 920                 925             


Pro Val Arg Leu Cys Ile Gly Glu Cys Lys Pro Glu Phe Met Thr Lys 
    930                 935                 940                 


Ser His Gln Gln Tyr Thr Phe Val Asn Pro Ser Val Leu Ser Leu Asn 
945                 950                 955                 960 


Pro Ile Arg Gly Pro Glu Ser Gly Gly Thr Met Val Thr Ile Thr Gly 
                965                 970                 975     


His Tyr Leu Gly Ala Gly Ser Ser Val Ala Val Tyr Leu Gly Asn Gln 
            980                 985                 990         


Thr Cys Glu Phe Tyr Gly Arg Ser  Met Ser Glu Ile Val  Cys Val Ser 
        995                 1000                 1005             


Pro Pro  Ser Ser Asn Gly Leu  Gly Pro Val Pro Val  Ser Val Ser 
    1010                 1015                 1020             


Val Asp  Arg Ala His Val Asp  Ser Asn Leu Gln Phe  Glu Tyr Ile 
    1025                 1030                 1035             


Asp Asp  Pro Arg Val Gln Arg  Ile Glu Pro Glu Trp  Ser Ile Ala 
    1040                 1045                 1050             


Ser Gly  His Thr Pro Leu Thr  Ile Thr Gly Phe Asn  Leu Asp Val 
    1055                 1060                 1065             


Ile Gln  Glu Pro Arg Ile Arg  Val Lys Phe Asn Gly  Lys Glu Ser 
    1070                 1075                 1080             


Val Asn  Val Cys Lys Val Val  Asn Thr Thr Thr Leu  Thr Cys Leu 
    1085                 1090                 1095             


Ala Pro  Ser Leu Thr Thr Asp  Tyr Arg Pro Gly Leu  Asp Thr Val 
    1100                 1105                 1110             


Glu Arg  Pro Asp Glu Phe Gly  Phe Val Phe Asn Asn  Val Gln Ser 
    1115                 1120                 1125             


Leu Leu  Ile Tyr Asn Asp Thr  Lys Phe Ile Tyr Tyr  Pro Asn Pro 
    1130                 1135                 1140             


Thr Phe  Glu Leu Leu Ser Pro  Thr Gly Val Leu Asp  Gln Lys Pro 
    1145                 1150                 1155             


Gly Ser  Pro Ile Ile Leu Lys  Gly Lys Asn Leu Cys  Pro Pro Ala 
    1160                 1165                 1170             


Ser Gly  Gly Ala Lys Leu Asn  Tyr Thr Val Leu Ile  Gly Glu Thr 
    1175                 1180                 1185             


Pro Cys  Ala Val Thr Val Ser  Glu Thr Gln Leu Leu  Cys Glu Pro 
    1190                 1195                 1200             


Pro Asn  Leu Thr Gly Gln His  Lys Val Met Val His  Val Gly Gly 
    1205                 1210                 1215             


Met Val  Phe Ser Pro Gly Ser  Val Ser Val Ile Ser  Asp Ser Leu 
    1220                 1225                 1230             


Leu Thr  Leu Pro Ala Ile Val  Ser Ile Ala Ala Gly  Gly Ser Leu 
    1235                 1240                 1245             


Leu Leu  Ile Ile Val Ile Ile  Val Leu Ile Ala Tyr  Lys Arg Lys 
    1250                 1255                 1260             


Ser Arg  Glu Asn Asp Leu Thr  Leu Lys Arg Leu Gln  Met Gln Met 
    1265                 1270                 1275             


Asp Asn  Leu Glu Ser Arg Val  Ala Leu Glu Cys Lys  Glu Ala Phe 
    1280                 1285                 1290             


Ala Glu  Leu Gln Thr Asp Ile  Asn Glu Leu Thr Ser  Asp Leu Asp 
    1295                 1300                 1305             


Arg Ser  Gly Ile Pro Tyr Leu  Asp Tyr Arg Thr Tyr  Ala Met Arg 
    1310                 1315                 1320             


Val Leu  Phe Pro Gly Ile Glu  Asp His Pro Val Leu  Arg Glu Leu 
    1325                 1330                 1335             


Glu Val  Gln Gly Asn Gly Gln  Gln His Val Glu Lys  Ala Leu Lys 
    1340                 1345                 1350             


Leu Phe  Ala Gln Leu Ile Asn  Asn Lys Val Phe Leu  Leu Thr Phe 
    1355                 1360                 1365             


Ile Arg  Thr Leu Glu Leu Gln  Arg Ser Phe Ser Met  Arg Asp Arg 
    1370                 1375                 1380             


Gly Asn  Val Ala Ser Leu Ile  Met Thr Gly Leu Gln  Gly Arg Leu 
    1385                 1390                 1395             


Glu Tyr  Ala Thr Asp Val Leu  Lys Gln Leu Leu Ser  Asp Leu Ile 
    1400                 1405                 1410             


Asp Lys  Asn Leu Glu Asn Lys  Asn His Pro Lys Leu  Leu Leu Arg 
    1415                 1420                 1425             


Arg Thr  Glu Ser Val Ala Glu  Lys Met Leu Thr Asn  Trp Phe Ala 
    1430                 1435                 1440             


Phe Leu  Leu His Lys Phe Leu  Lys Glu Cys Ala Gly  Glu Pro Leu 
    1445                 1450                 1455             


Phe Met  Leu Tyr Cys Ala Ile  Lys Gln Gln Met Glu  Lys Gly Pro 
    1460                 1465                 1470             


Ile Asp  Ala Ile Thr Gly Glu  Ala Arg Tyr Ser Leu  Ser Glu Asp 
    1475                 1480                 1485             


Lys Leu  Ile Arg Gln Gln Ile  Glu Tyr Lys Thr Leu  Ile Leu Asn 
    1490                 1495                 1500             


Cys Val  Asn Pro Asp Asn Glu  Asn Ser Pro Glu Ile  Pro Val Lys 
    1505                 1510                 1515             


Val Leu  Asn Cys Asp Thr Ile  Thr Gln Val Lys Glu  Lys Ile Leu 
    1520                 1525                 1530             


Asp Ala  Val Tyr Lys Asn Val  Pro Tyr Ser Gln Arg  Pro Arg Ala 
    1535                 1540                 1545             


Val Asp  Met Asp Leu Glu Trp  Arg Gln Gly Arg Ile  Ala Arg Val 
    1550                 1555                 1560             


Val Leu  Gln Asp Glu Asp Ile  Thr Thr Lys Ile Glu  Gly Asp Trp 
    1565                 1570                 1575             


Lys Arg  Leu Asn Thr Leu Met  His Tyr Gln Val Ser  Asp Arg Ser 
    1580                 1585                 1590             


Val Val  Ala Leu Val Pro Lys  Gln Thr Ser Ser Tyr  Asn Ile Pro 
    1595                 1600                 1605             


Ala Ser  Ala Ser Ile Ser Arg  Thr Ser Ile Ser Arg  Tyr Asp Ser 
    1610                 1615                 1620             


Ser Phe  Arg Tyr Thr Gly Ser  Pro Asp Ser Leu Arg  Ser Arg Ala 
    1625                 1630                 1635             


Pro Met  Ile Thr Pro Asp Leu  Glu Ser Gly Val Lys  Val Trp His 
    1640                 1645                 1650             


Leu Val  Lys Asn His Asp His  Gly Asp Gln Lys Glu  Gly Asp Arg 
    1655                 1660                 1665             


Gly Ser  Lys Met Val Ser Glu  Ile Tyr Leu Thr Arg  Leu Leu Ala 
    1670                 1675                 1680             


Thr Lys  Gly Thr Leu Gln Lys  Phe Val Asp Asp Leu  Phe Glu Thr 
    1685                 1690                 1695             


Leu Phe  Ser Thr Val His Arg  Gly Ser Ala Leu Pro  Leu Ala Ile 
    1700                 1705                 1710             


Lys Tyr  Met Phe Asp Phe Leu  Asp Glu Gln Ala Asp  Arg His Ser 
    1715                 1720                 1725             


Ile His  Asp Thr Asp Val Arg  His Thr Trp Lys Ser  Asn Cys Leu 
    1730                 1735                 1740             


Pro Leu  Arg Phe Trp Val Asn  Val Ile Lys Asn Pro  Gln Phe Val 
    1745                 1750                 1755             


Phe Asp  Ile His Lys Gly Ser  Ile Thr Asp Ala Cys  Leu Ser Val 
    1760                 1765                 1770             


Val Ala  Gln Thr Phe Met Asp  Ser Cys Ser Thr Ser  Glu His Arg 
    1775                 1780                 1785             


Leu Gly  Lys Asp Ser Pro Ser  Asn Lys Leu Leu Tyr  Ala Lys Asp 
    1790                 1795                 1800             


Ile Pro  Ser Tyr Lys Ser Trp  Val Glu Arg Tyr Tyr  Ala Asp Ile 
    1805                 1810                 1815             


Ala Lys  Leu Pro Ala Ile Ser  Asp Gln Asp Met Asn  Ala Tyr Leu 
    1820                 1825                 1830             


Ala Glu  Gln Ser Arg Leu His  Ala Val Glu Phe Asn  Met Leu Ser 
    1835                 1840                 1845             


Ala Leu  Asn Glu Ile Tyr Ser  Tyr Val Ser Lys Tyr  Ser Glu Glu 
    1850                 1855                 1860             


Leu Ile  Gly Ala Leu Glu Gln  Asp Glu Gln Ala Arg  Arg Gln Arg 
    1865                 1870                 1875             


Leu Ala  Tyr Lys Val Glu Gln  Leu Ile Asn Ala Met  Ser Ile Glu 
    1880                 1885                 1890             


Ser 
    


<210>  39
<211>  947
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Glu Phe Ser Trp Gly Ser Gly Gln Glu Ser Arg Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Glu Ala Gly Asn Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Gly Arg Gly Gly Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Arg Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Ser Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Glu Lys Pro Pro Asp Asp Glu Leu Val Lys Gly Leu 
            180                 185                 190         


Gly Leu Ile Leu Arg Lys Ser Leu Asp Arg Glu Glu Ala Pro Glu Ile 
        195                 200                 205             


Phe Leu Val Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Ala Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Asp Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Val Pro 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Val Tyr Ser Phe Ser Asn Asp Ile Ser Pro Asn 
        275                 280                 285             


Val Lys Ser Lys Phe His Ile Asp Pro Ile Thr Gly Gln Ile Ile Val 
    290                 295                 300                 


Lys Gly Tyr Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Ile Val 
305                 310                 315                 320 


Glu Gly Ile Asp Lys Gly Gln Leu Pro Leu Ser Gly His Cys Arg Val 
                325                 330                 335     


Ile Val Glu Val Glu Asp Asn Asn Asp Asn Val Pro Asp Leu Glu Phe 
            340                 345                 350         


Lys Ser Leu Ser Leu Pro Ile Arg Glu Asp Ala Pro Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Lys Asp Met Gly Val Asn Gly Leu 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Ser His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Thr Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Val Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Leu Val Gly Ala Val Gly 
        675                 680                 685             


Pro Asp Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Asp Ser Arg Asp Arg Glu Asp 
    770                 775                 780                 


Gln Leu Gln Thr Thr Glu Glu Ser Phe Ala Lys Pro Arg Gln Pro Asn 
785                 790                 795                 800 


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
                805                 810                 815     


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
            820                 825                 830         


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
        835                 840                 845             


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
    850                 855                 860                 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
865                 870                 875                 880 


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
                885                 890                 895     


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
            900                 905                 910         


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
        915                 920                 925             


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
    930                 935                 940                 


Ser Asp Gln 
945         


<210>  40
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Phe Ser Trp Gly Ser Gly Gln Glu Ser Arg Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Glu Ala Gly Asn Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Gly Arg Gly Gly Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Arg Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Ser Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Glu Lys Pro Pro Asp Asp Glu Leu Val Lys Gly Leu 
            180                 185                 190         


Gly Leu Ile Leu Arg Lys Ser Leu Asp Arg Glu Glu Ala Pro Glu Ile 
        195                 200                 205             


Phe Leu Val Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Ala Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Asp Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Val Pro 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Val Tyr Ser Phe Ser Asn Asp Ile Ser Pro Asn 
        275                 280                 285             


Val Lys Ser Lys Phe His Ile Asp Pro Ile Thr Gly Gln Ile Ile Val 
    290                 295                 300                 


Lys Gly Tyr Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Ile Val 
305                 310                 315                 320 


Glu Gly Ile Asp Lys Gly Gln Leu Pro Leu Ser Gly His Cys Arg Val 
                325                 330                 335     


Ile Val Glu Val Glu Asp Asn Asn Asp Asn Val Pro Asp Leu Glu Phe 
            340                 345                 350         


Lys Ser Leu Ser Leu Pro Ile Arg Glu Asp Ala Pro Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Lys Asp Met Gly Val Asn Gly Leu 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Ser His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Thr Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Val Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Leu Val Gly Ala Val Gly 
        675                 680                 685             


Pro Asp Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Asp Ser Arg Asp Arg Glu Asp 
    770                 775                 780                 


Gln Leu Gln Thr Thr Glu Glu Ser Phe Ala Lys Val Ser Val 
785                 790                 795             


<210>  41
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 
    850                 855                 860                 


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
865                 870                 875                 880 


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
                885                 890                 895     


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
            900                 905                 910         


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
        915                 920                 925             


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
    930                 935                 940                 


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
945                 950                 955                 960 


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
                965                 970                 975     


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
            980                 985                 990         


Glu Lys Lys Glu Lys Gly Asn Ser  Thr Thr Asp Asn Ser  Asp Gln 
        995                 1000                 1005         


<210>  42
<211>  884
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Val Arg Gln Trp Ser Gly Gly Leu Leu 
    850                 855                 860                 


Gln Thr His Ala Phe Val Thr His Pro Pro Ile Ser Cys Asp Leu Ala 
865                 870                 875                 880 


Leu Leu Ser His 
                


<210>  43
<211>  1028
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Arg Leu Leu Trp Lys Leu Val Ile Leu Leu Pro Leu Ile Asn Ser 
1               5                   10                  15      


Ser Ala Gly Asp Gly Leu Leu Ser Arg Pro Ile Phe Thr Gln Glu Pro 
            20                  25                  30          


His Asp Val Ile Phe Pro Leu Asp Leu Ser Lys Ser Glu Val Ile Leu 
        35                  40                  45              


Asn Cys Ala Ala Asn Gly Tyr Pro Ser Pro His Tyr Arg Trp Lys Gln 
    50                  55                  60                  


Asn Gly Thr Asp Ile Asp Phe Thr Met Ser Tyr His Tyr Arg Leu Asp 
65                  70                  75                  80  


Gly Gly Ser Leu Ala Ile Asn Ser Pro His Thr Asp Gln Asp Ile Gly 
                85                  90                  95      


Met Tyr Gln Cys Leu Ala Thr Asn Leu Leu Gly Thr Ile Leu Ser Arg 
            100                 105                 110         


Lys Ala Lys Leu Gln Phe Ala Tyr Ile Glu Asp Phe Glu Thr Lys Thr 
        115                 120                 125             


Arg Ser Thr Val Ser Val Arg Glu Gly Gln Gly Val Val Leu Leu Cys 
    130                 135                 140                 


Gly Pro Pro Pro His Phe Gly Asp Leu Ser Tyr Ala Trp Thr Phe Asn 
145                 150                 155                 160 


Asp Asn Pro Leu Tyr Val Gln Glu Asp Asn Arg Arg Phe Val Ser Gln 
                165                 170                 175     


Glu Thr Gly Asn Leu Tyr Ile Ala Lys Val Glu Pro Ser Asp Val Gly 
            180                 185                 190         


Asn Tyr Thr Cys Phe Ile Thr Asn Lys Glu Ala Gln Arg Ser Val Gln 
        195                 200                 205             


Gly Pro Pro Thr Pro Leu Val Gln Arg Thr Asp Gly Val Met Gly Glu 
    210                 215                 220                 


Tyr Glu Pro Lys Ile Glu Val Arg Phe Pro Glu Thr Ile Gln Ala Ala 
225                 230                 235                 240 


Lys Asp Ser Ser Val Lys Leu Glu Cys Phe Ala Leu Gly Asn Pro Val 
                245                 250                 255     


Pro Asp Ile Ser Trp Arg Arg Leu Asp Gly Ser Pro Leu Pro Gly Lys 
            260                 265                 270         


Val Lys Tyr Ser Lys Ser Gln Ala Ile Leu Glu Ile Pro Asn Phe Gln 
        275                 280                 285             


Gln Glu Asp Glu Gly Phe Tyr Glu Cys Ile Ala Ser Asn Leu Arg Gly 
    290                 295                 300                 


Arg Asn Leu Ala Lys Gly Gln Leu Ile Phe Tyr Ala Pro Pro Glu Trp 
305                 310                 315                 320 


Glu Gln Lys Ile Gln Asn Thr His Leu Ser Ile Tyr Asp Asn Leu Leu 
                325                 330                 335     


Trp Glu Cys Lys Ala Ser Gly Lys Pro Asn Pro Trp Tyr Thr Trp Leu 
            340                 345                 350         


Lys Asn Gly Glu Arg Leu Asn Pro Glu Glu Arg Ile Gln Ile Glu Asn 
        355                 360                 365             


Gly Thr Leu Ile Ile Thr Met Leu Asn Val Ser Asp Ser Gly Val Tyr 
    370                 375                 380                 


Gln Cys Ala Ala Glu Asn Lys Tyr Gln Ile Ile Tyr Ala Asn Ala Glu 
385                 390                 395                 400 


Leu Arg Val Leu Ala Ser Ala Pro Asp Phe Ser Lys Ser Pro Val Lys 
                405                 410                 415     


Lys Lys Ser Phe Val Gln Val Gly Gly Asp Ile Val Ile Gly Cys Lys 
            420                 425                 430         


Pro Asn Ala Phe Pro Arg Ala Ala Ile Ser Trp Lys Arg Gly Thr Glu 
        435                 440                 445             


Thr Leu Arg Gln Ser Lys Arg Ile Phe Leu Leu Glu Asp Gly Ser Leu 
    450                 455                 460                 


Lys Ile Tyr Asn Ile Thr Arg Ser Asp Ala Gly Ser Tyr Thr Cys Ile 
465                 470                 475                 480 


Ala Thr Asn Gln Phe Gly Thr Ala Lys Asn Thr Gly Ser Leu Ile Val 
                485                 490                 495     


Lys Glu Arg Thr Val Ile Thr Val Pro Pro Ser Lys Met Asp Val Thr 
            500                 505                 510         


Val Gly Glu Ser Ile Val Leu Pro Cys Gln Val Ser His Asp Pro Ser 
        515                 520                 525             


Ile Glu Val Val Phe Val Trp Phe Phe Asn Gly Asp Val Ile Asp Leu 
    530                 535                 540                 


Lys Lys Gly Val Ala His Phe Glu Arg Ile Gly Gly Glu Ser Val Gly 
545                 550                 555                 560 


Asp Leu Met Ile Arg Asn Ile Gln Leu His His Ser Gly Lys Tyr Leu 
                565                 570                 575     


Cys Thr Val Gln Thr Thr Leu Glu Ser Leu Ser Ala Val Ala Asp Ile 
            580                 585                 590         


Ile Val Arg Gly Pro Pro Gly Pro Pro Glu Asp Val Gln Val Glu Asp 
        595                 600                 605             


Ile Ser Ser Thr Thr Ser Gln Leu Ser Trp Arg Ala Gly Pro Asp Asn 
    610                 615                 620                 


Asn Ser Pro Ile Gln Ile Phe Thr Ile Gln Thr Arg Thr Pro Phe Ser 
625                 630                 635                 640 


Val Gly Trp Gln Ala Val Ala Thr Val Pro Glu Ile Leu Asn Gly Lys 
                645                 650                 655     


Thr Tyr Asn Ala Thr Val Val Gly Leu Ser Pro Trp Val Glu Tyr Glu 
            660                 665                 670         


Phe Arg Val Val Ala Gly Asn Ser Ile Gly Ile Gly Glu Pro Ser Glu 
        675                 680                 685             


Pro Ser Glu Leu Leu Arg Thr Lys Ala Ser Val Pro Val Val Ala Pro 
    690                 695                 700                 


Val Asn Ile His Gly Gly Gly Gly Ser Arg Ser Glu Leu Val Ile Thr 
705                 710                 715                 720 


Trp Glu Ser Ile Pro Glu Glu Leu Gln Asn Gly Glu Gly Phe Gly Tyr 
                725                 730                 735     


Ile Ile Met Phe Arg Pro Val Gly Ser Thr Thr Trp Ser Lys Glu Lys 
            740                 745                 750         


Val Ser Ser Val Glu Ser Ser Arg Phe Val Tyr Arg Asn Glu Ser Ile 
        755                 760                 765             


Ile Pro Leu Ser Pro Phe Glu Val Lys Val Gly Val Tyr Asn Asn Glu 
    770                 775                 780                 


Gly Glu Gly Ser Leu Ser Thr Val Thr Ile Val Tyr Ser Gly Glu Asp 
785                 790                 795                 800 


Glu Pro Gln Leu Ala Pro Arg Gly Thr Ser Leu Gln Ser Phe Ser Ala 
                805                 810                 815     


Ser Glu Met Glu Val Ser Trp Asn Ala Ile Ala Trp Asn Arg Asn Thr 
            820                 825                 830         


Gly Arg Val Leu Gly Tyr Glu Val Leu Tyr Trp Thr Asp Asp Ser Lys 
        835                 840                 845             


Glu Ser Met Ile Gly Lys Ile Arg Val Ser Gly Asn Val Thr Thr Lys 
    850                 855                 860                 


Asn Ile Thr Gly Leu Lys Ala Asn Thr Ile Tyr Phe Ala Ser Val Arg 
865                 870                 875                 880 


Ala Tyr Asn Thr Ala Gly Thr Gly Pro Ser Ser Pro Pro Val Asn Val 
                885                 890                 895     


Thr Thr Lys Lys Ser Pro Pro Ser Gln Pro Pro Ala Asn Ile Ala Trp 
            900                 905                 910         


Lys Leu Thr Asn Ser Lys Leu Cys Leu Asn Trp Glu His Val Lys Thr 
        915                 920                 925             


Met Glu Asn Glu Ser Glu Val Leu Gly Tyr Lys Ile Leu Tyr Arg Gln 
    930                 935                 940                 


Asn Arg Gln Ser Lys Thr His Ile Leu Glu Thr Asn Asn Thr Ser Ala 
945                 950                 955                 960 


Glu Leu Leu Val Pro Phe Glu Glu Asp Tyr Leu Ile Glu Ile Arg Thr 
                965                 970                 975     


Val Ser Asp Gly Gly Asp Gly Ser Ser Ser Glu Glu Ile Arg Ile Pro 
            980                 985                 990         


Lys Met Ser Ser Leu Ser Ser Arg  Gly Ile Gln Phe Leu  Glu Pro Ser 
        995                 1000                 1005             


Thr His  Phe Leu Ser Ile Val  Ile Val Ile Phe His  Cys Phe Ala 
    1010                 1015                 1020             


Ile Gln  Pro Leu Ile 
    1025             


<210>  44
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Arg Phe Gly Leu Pro Ala Leu Leu Cys Thr Leu Ala Val Leu 
1               5                   10                  15      


Ser Ala Ala Leu Leu Ala Ala Glu Leu Lys Ser Lys Ser Cys Ser Glu 
            20                  25                  30          


Val Arg Arg Leu Tyr Val Ser Lys Gly Phe Asn Lys Asn Asp Ala Pro 
        35                  40                  45              


Leu His Glu Ile Asn Gly Asp His Leu Lys Ile Cys Pro Gln Gly Ser 
    50                  55                  60                  


Thr Cys Cys Ser Gln Glu Met Glu Glu Lys Tyr Ser Leu Gln Ser Lys 
65                  70                  75                  80  


Asp Asp Phe Lys Ser Val Val Ser Glu Gln Cys Asn His Leu Gln Ala 
                85                  90                  95      


Val Phe Ala Ser Arg Tyr Lys Lys Phe Asp Glu Phe Phe Lys Glu Leu 
            100                 105                 110         


Leu Glu Asn Ala Glu Lys Ser Leu Asn Asp Met Phe Val Lys Thr Tyr 
        115                 120                 125             


Gly His Leu Tyr Met Gln Asn Ser Glu Leu Phe Lys Asp Leu Phe Val 
    130                 135                 140                 


Glu Leu Lys Arg Tyr Tyr Val Val Gly Asn Val Asn Leu Glu Glu Met 
145                 150                 155                 160 


Leu Asn Asp Phe Trp Ala Arg Leu Leu Glu Arg Met Phe Arg Leu Val 
                165                 170                 175     


Asn Ser Gln Tyr His Phe Thr Asp Glu Tyr Leu Glu Cys Val Ser Lys 
            180                 185                 190         


Tyr Thr Glu Gln Leu Lys Pro Phe Gly Asp Val Pro Arg Lys Leu Lys 
        195                 200                 205             


Leu Gln Val Thr Arg Ala Phe Val Ala Ala Arg Thr Phe Ala Gln Gly 
    210                 215                 220                 


Leu Ala Val Ala Gly Asp Val Val Ser Lys Val Ser Val Val Asn Pro 
225                 230                 235                 240 


Thr Ala Gln Cys Thr His Ala Leu Leu Lys Met Ile Tyr Cys Ser His 
                245                 250                 255     


Cys Arg Gly Leu Val Thr Val Lys Pro Cys Tyr Asn Tyr Cys Ser Asn 
            260                 265                 270         


Ile Met Arg Gly Cys Leu Ala Asn Gln Gly Asp Leu Asp Phe Glu Trp 
        275                 280                 285             


Asn Asn Phe Ile Asp Ala Met Leu Met Val Ala Glu Arg Leu Glu Gly 
    290                 295                 300                 


Pro Phe Asn Ile Glu Ser Val Met Asp Pro Ile Asp Val Lys Ile Ser 
305                 310                 315                 320 


Asp Ala Ile Met Asn Met Gln Asp Asn Ser Val Gln Val Ser Gln Lys 
                325                 330                 335     


Val Phe Gln Gly Cys Gly Pro Pro Lys Pro Leu Pro Ala Gly Arg Ile 
            340                 345                 350         


Ser Arg Ser Ile Ser Glu Ser Ala Phe Ser Ala Arg Phe Arg Pro His 
        355                 360                 365             


His Pro Glu Glu Arg Pro Thr Thr Ala Ala Gly Thr Ser Leu Asp Arg 
    370                 375                 380                 


Leu Val Thr Asp Val Lys Glu Lys Leu Lys Gln Ala Lys Lys Phe Trp 
385                 390                 395                 400 


Ser Ser Leu Pro Ser Asn Val Cys Asn Asp Glu Arg Met Ala Ala Gly 
                405                 410                 415     


Asn Gly Asn Glu Asp Asp Cys Trp Asn Gly Lys Gly Lys Ser Arg Tyr 
            420                 425                 430         


Leu Phe Ala Val Thr Gly Asn Gly Leu Ala Asn Gln Gly Asn Asn Pro 
        435                 440                 445             


Glu Val Gln Val Asp Thr Ser Lys Pro Asp Ile Leu Ile Leu Arg Gln 
    450                 455                 460                 


Ile Met Ala Leu Arg Val Met Thr Ser Lys Met Lys Asn Ala Tyr Asn 
465                 470                 475                 480 


Gly Asn Asp Val Asp Phe Phe Asp Ile Ser Asp Glu Ser Ser Gly Glu 
                485                 490                 495     


Gly Ser Gly Ser Gly Cys Glu Tyr Gln Gln Cys Pro Ser Glu Phe Asp 
            500                 505                 510         


Tyr Asn Ala Thr Asp His Ala Gly Lys Ser Ala Asn Glu Lys Ala Asp 
        515                 520                 525             


Ser Ala Gly Val Arg Pro Gly Ala Gln Ala Tyr Leu Leu Thr Val Phe 
    530                 535                 540                 


Cys Ile Leu Phe Leu Val Met Gln Arg Glu Trp Arg 
545                 550                 555     


<210>  45
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Glu Pro Gly Asp Ala Ala Arg Pro Gly Ser Gly Arg Ala Thr Gly 
1               5                   10                  15      


Ala Pro Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Gly Trp Gly 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Ala Ser Ala Ser Ser Ser Gly Ala Ala Ala 
        35                  40                  45              


Glu Asp Ser Ser Ala Met Glu Glu Leu Ala Thr Glu Lys Glu Ala Glu 
    50                  55                  60                  


Glu Ser His Arg Gln Asp Ser Val Ser Leu Leu Thr Phe Ile Leu Leu 
65                  70                  75                  80  


Leu Thr Leu Thr Ile Leu Thr Ile Trp Leu Phe Lys His Arg Arg Val 
                85                  90                  95      


Arg Phe Leu His Glu Thr Gly Leu Ala Met Ile Tyr Gly Leu Ile Val 
            100                 105                 110         


Gly Val Ile Leu Arg Tyr Gly Thr Pro Ala Thr Ser Gly Arg Asp Lys 
        115                 120                 125             


Ser Leu Ser Cys Thr Gln Glu Asp Arg Ala Phe Ser Thr Leu Leu Val 
    130                 135                 140                 


Asn Val Ser Gly Lys Phe Phe Glu Tyr Thr Leu Lys Gly Glu Ile Ser 
145                 150                 155                 160 


Pro Gly Lys Ile Asn Ser Val Glu Gln Asn Asp Met Leu Arg Lys Val 
                165                 170                 175     


Thr Phe Asp Pro Glu Val Phe Phe Asn Ile Leu Leu Pro Pro Ile Ile 
            180                 185                 190         


Phe His Ala Gly Tyr Ser Leu Lys Lys Arg His Phe Phe Arg Asn Leu 
        195                 200                 205             


Gly Ser Ile Leu Ala Tyr Ala Phe Leu Gly Thr Ala Val Ser Cys Phe 
    210                 215                 220                 


Ile Ile Gly Asn Leu Met Tyr Gly Val Val Lys Leu Met Lys Ile Met 
225                 230                 235                 240 


Gly Gln Leu Ser Asp Lys Phe Tyr Tyr Thr Asp Cys Leu Phe Phe Gly 
                245                 250                 255     


Ala Ile Ile Ser Ala Thr Asp Pro Val Thr Val Leu Ala Ile Phe Asn 
            260                 265                 270         


Glu Leu His Ala Asp Val Asp Leu Tyr Ala Leu Leu Phe Gly Glu Ser 
        275                 280                 285             


Val Leu Asn Asp Ala Val Ala Ile Val Leu Ser Ser Ser Ile Val Ala 
    290                 295                 300                 


Tyr Gln Pro Ala Gly Leu Asn Thr His Ala Phe Asp Ala Ala Ala Phe 
305                 310                 315                 320 


Phe Lys Ser Val Gly Ile Phe Leu Gly Ile Phe Ser Gly Ser Phe Thr 
                325                 330                 335     


Met Gly Ala Val Thr Gly Val Val Thr Ala Leu Val Thr Lys Phe Thr 
            340                 345                 350         


Lys Leu His Cys Phe Pro Leu Leu Glu Thr Ala Leu Phe Phe Leu Met 
        355                 360                 365             


Ser Trp Ser Thr Phe Leu Leu Ala Glu Ala Cys Gly Phe Thr Gly Val 
    370                 375                 380                 


Val Ala Val Leu Phe Cys Gly Ile Thr Gln Ala His Tyr Thr Tyr Asn 
385                 390                 395                 400 


Asn Leu Ser Val Glu Ser Arg Ser Arg Thr Lys Gln Leu Phe Glu Val 
                405                 410                 415     


Leu His Phe Leu Ala Glu Asn Phe Ile Phe Ser Tyr Met Gly Leu Ala 
            420                 425                 430         


Leu Phe Thr Phe Gln Lys His Val Phe Ser Pro Ile Phe Ile Ile Gly 
        435                 440                 445             


Ala Phe Val Ala Ile Phe Leu Gly Arg Ala Ala His Ile Tyr Pro Leu 
    450                 455                 460                 


Ser Phe Phe Leu Asn Leu Gly Arg Arg His Lys Ile Gly Trp Asn Phe 
465                 470                 475                 480 


Gln His Met Met Met Phe Ser Gly Leu Arg Gly Ala Met Ala Phe Ala 
                485                 490                 495     


Leu Ala Ile Arg Asp Thr Ala Ser Tyr Ala Arg Gln Met Met Phe Thr 
            500                 505                 510         


Thr Thr Leu Leu Ile Val Phe Phe Thr Val Trp Ile Ile Gly Gly Gly 
        515                 520                 525             


Thr Thr Pro Met Leu Ser Trp Leu Asn Ile Arg Val Gly Val Glu Glu 
    530                 535                 540                 


Pro Ser Glu Glu Asp Gln Asn Glu His His Trp Gln Tyr Phe Arg Val 
545                 550                 555                 560 


Gly Val Asp Pro Asp Gln Asp Pro Pro Pro Asn Asn Asp Ser Phe Gln 
                565                 570                 575     


Val Leu Gln Gly Asp Gly Pro Asp Ser Ala Arg Gly Asn Arg Thr Lys 
            580                 585                 590         


Gln Glu Ser Ala Trp Ile Phe Arg Leu Trp Tyr Ser Phe Asp His Asn 
        595                 600                 605             


Tyr Leu Lys Pro Ile Leu Thr His Ser Gly Pro Pro Leu Thr Thr Thr 
    610                 615                 620                 


Leu Pro Ala Trp Cys Gly Leu Leu Ala Arg Cys Leu Thr Ser Pro Gln 
625                 630                 635                 640 


Val Tyr Asp Asn Gln Glu Pro Leu Arg Glu Glu Asp Ser Asp Phe Ile 
                645                 650                 655     


Leu Thr Glu Gly Asp Leu Thr Leu Thr Tyr Gly Asp Ser Thr Val Thr 
            660                 665                 670         


Ala Asn Gly Ser Ser Ser Ser His Thr Ala Ser Thr Ser Leu Glu Gly 
        675                 680                 685             


Ser Arg Arg Thr Lys Ser Ser Ser Glu Glu Val Leu Glu Arg Asp Leu 
    690                 695                 700                 


Gly Met Gly Asp Gln Lys Val Ser Ser Arg Gly Thr Arg Leu Val Phe 
705                 710                 715                 720 


Pro Leu Glu Asp Asn Ala 
                725     


<210>  46
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Glu Pro Gly Asp Ala Ala Arg Pro Gly Ser Gly Arg Ala Thr Gly 
1               5                   10                  15      


Ala Pro Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Gly Trp Gly 
            20                  25                  30          


Leu Arg Val Ala Ala Ala Ala Ser Ala Ser Ser Ser Gly Ala Ala Ala 
        35                  40                  45              


Glu Asp Ser Ser Ala Met Glu Glu Leu Ala Thr Glu Lys Glu Ala Glu 
    50                  55                  60                  


Glu Ser His Arg Gln Asp Ser Val Ser Leu Leu Thr Phe Ile Leu Leu 
65                  70                  75                  80  


Leu Thr Leu Thr Ile Leu Thr Ile Trp Leu Phe Lys His Arg Arg Val 
                85                  90                  95      


Arg Phe Leu His Glu Thr Gly Leu Ala Met Ile Tyr Gly Leu Ile Val 
            100                 105                 110         


Gly Val Ile Leu Arg Tyr Gly Thr Pro Ala Thr Ser Gly Arg Asp Lys 
        115                 120                 125             


Ser Leu Ser Cys Thr Gln Glu Asp Arg Ala Phe Ser Thr Leu Leu Val 
    130                 135                 140                 


Asn Val Ser Gly Lys Phe Phe Glu Tyr Thr Leu Lys Gly Glu Ile Ser 
145                 150                 155                 160 


Pro Gly Lys Ile Asn Ser Val Glu Gln Asn Asp Met Leu Arg Lys Val 
                165                 170                 175     


Thr Phe Asp Pro Glu Val Phe Phe Asn Ile Leu Leu Pro Pro Ile Ile 
            180                 185                 190         


Phe His Ala Gly Tyr Ser Leu Lys Lys Arg His Phe Phe Arg Asn Leu 
        195                 200                 205             


Gly Ser Ile Leu Ala Tyr Ala Phe Leu Gly Thr Ala Val Ser Cys Phe 
    210                 215                 220                 


Ile Ile Gly Asn Leu Met Tyr Gly Val Val Lys Leu Met Lys Ile Met 
225                 230                 235                 240 


Gly Gln Leu Ser Asp Lys Phe Tyr Tyr Thr Asp Cys Leu Phe Phe Gly 
                245                 250                 255     


Ala Ile Ile Ser Ala Thr Asp Pro Val Thr Val Leu Ala Ile Phe Asn 
            260                 265                 270         


Glu Leu His Ala Asp Val Asp Leu Tyr Ala Leu Leu Phe Gly Glu Ser 
        275                 280                 285             


Val Leu Asn Asp Ala Val Ala Ile Val Leu Ser Ser Ser Ile Val Ala 
    290                 295                 300                 


Tyr Gln Pro Ala Gly Leu Asn Thr His Ala Phe Asp Ala Ala Ala Phe 
305                 310                 315                 320 


Phe Lys Ser Val Gly Ile Phe Leu Gly Ile Phe Ser Gly Ser Phe Thr 
                325                 330                 335     


Met Gly Ala Val Thr Gly Val Asn Ala Asn Val Thr Lys Phe Thr Lys 
            340                 345                 350         


Leu His Cys Phe Pro Leu Leu Glu Thr Ala Leu Phe Phe Leu Met Ser 
        355                 360                 365             


Trp Ser Thr Phe Leu Leu Ala Glu Ala Cys Gly Phe Thr Gly Val Val 
    370                 375                 380                 


Ala Val Leu Phe Cys Gly Ile Thr Gln Ala His Tyr Thr Tyr Asn Asn 
385                 390                 395                 400 


Leu Ser Val Glu Ser Arg Ser Arg Thr Lys Gln Leu Phe Glu Val Leu 
                405                 410                 415     


His Phe Leu Ala Glu Asn Phe Ile Phe Ser Tyr Met Gly Leu Ala Leu 
            420                 425                 430         


Phe Thr Phe Gln Lys His Val Phe Ser Pro Ile Phe Ile Ile Gly Ala 
        435                 440                 445             


Phe Val Ala Ile Phe Leu Gly Arg Ala Ala His Ile Tyr Pro Leu Ser 
    450                 455                 460                 


Phe Phe Leu Asn Leu Gly Arg Arg His Lys Ile Gly Trp Asn Phe Gln 
465                 470                 475                 480 


His Met Met Met Phe Ser Gly Leu Arg Gly Ala Met Ala Phe Ala Leu 
                485                 490                 495     


Ala Ile Arg Asp Thr Ala Ser Tyr Ala Arg Gln Met Met Phe Thr Thr 
            500                 505                 510         


Thr Leu Leu Ile Val Phe Phe Thr Val Trp Ile Ile Gly Gly Gly Thr 
        515                 520                 525             


Thr Pro Met Leu Ser Trp Leu Asn Ile Arg Val Gly Val Glu Glu Pro 
    530                 535                 540                 


Ser Glu Glu Asp Gln Asn Glu His His Trp Gln Tyr Phe Arg Val Gly 
545                 550                 555                 560 


Val Asp Pro Asp Gln Asp Pro Pro Pro Asn Asn Asp Ser Phe Gln Val 
                565                 570                 575     


Leu Gln Gly Asp Gly Pro Asp Ser Ala Arg Gly Asn Arg Thr Lys Gln 
            580                 585                 590         


Glu Ser Ala Trp Ile Phe Arg Leu Trp Tyr Ser Phe Asp His Asn Tyr 
        595                 600                 605             


Leu Lys Pro Ile Leu Thr His Ser Gly Pro Pro Leu Thr Thr Thr Leu 
    610                 615                 620                 


Pro Ala Trp Cys Gly Leu Leu Ala Arg Cys Leu Thr Ser Pro Gln Val 
625                 630                 635                 640 


Tyr Asp Asn Gln Glu Pro Leu Arg Glu Glu Asp Ser Asp Phe Ile Leu 
                645                 650                 655     


Thr Glu Gly Asp Leu Thr Leu Thr Tyr Gly Asp Ser Thr Val Thr Ala 
            660                 665                 670         


Asn Gly Ser Ser Ser Ser His Thr Ala Ser Thr Ser Leu Glu Gly Ser 
        675                 680                 685             


Arg Arg Thr Lys Ser Ser Ser Glu Glu Val Leu Glu Arg Asp Leu Gly 
    690                 695                 700                 


Met Gly Asp Gln Lys Val Ser Ser Arg Gly Thr Arg Leu Val Phe Pro 
705                 710                 715                 720 


Leu Glu Asp Asn Ala 
                725 


<210>  47
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Arg Thr Leu Arg Pro Ser Pro Leu Cys Pro Gly Gly Gly Lys 
1               5                   10                  15      


Ala Gln Leu Ser Ser Ala Ser Leu Leu Gly Ala Gly Leu Leu Leu Gln 
            20                  25                  30          


Pro Pro Thr Pro Pro Pro Leu Leu Leu Leu Leu Phe Pro Leu Leu Leu 
        35                  40                  45              


Phe Ser Arg Leu Cys Gly Ala Leu Ala Gly Pro Ile Ile Val Glu Pro 
    50                  55                  60                  


His Val Thr Ala Val Trp Gly Lys Asn Val Ser Leu Lys Cys Leu Ile 
65                  70                  75                  80  


Glu Val Asn Glu Thr Ile Thr Gln Ile Ser Trp Glu Lys Ile His Gly 
                85                  90                  95      


Lys Ser Ser Gln Thr Val Ala Val His His Pro Gln Tyr Gly Phe Ser 
            100                 105                 110         


Val Gln Gly Glu Tyr Gln Gly Arg Val Leu Phe Lys Asn Tyr Ser Leu 
        115                 120                 125             


Asn Asp Ala Thr Ile Thr Leu His Asn Ile Gly Phe Ser Asp Ser Gly 
    130                 135                 140                 


Lys Tyr Ile Cys Lys Ala Val Thr Phe Pro Leu Gly Asn Ala Gln Ser 
145                 150                 155                 160 


Ser Thr Thr Val Thr Val Leu Val Glu Pro Thr Val Ser Leu Ile Lys 
                165                 170                 175     


Gly Pro Asp Ser Leu Ile Asp Gly Gly Asn Glu Thr Val Ala Ala Ile 
            180                 185                 190         


Cys Ile Ala Ala Thr Gly Lys Pro Val Ala His Ile Asp Trp Glu Gly 
        195                 200                 205             


Asp Leu Gly Glu Met Glu Ser Thr Thr Thr Ser Phe Pro Asn Glu Thr 
    210                 215                 220                 


Ala Thr Ile Ile Ser Gln Tyr Lys Leu Phe Pro Thr Arg Phe Ala Arg 
225                 230                 235                 240 


Gly Arg Arg Ile Thr Cys Val Val Lys His Pro Ala Leu Glu Lys Asp 
                245                 250                 255     


Ile Arg Tyr Ser Phe Ile Leu Asp Ile Gln Tyr Ala Pro Glu Val Ser 
            260                 265                 270         


Val Thr Gly Tyr Asp Gly Asn Trp Phe Val Gly Arg Lys Gly Val Asn 
        275                 280                 285             


Leu Lys Cys Asn Ala Asp Ala Asn Pro Pro Pro Phe Lys Ser Val Trp 
    290                 295                 300                 


Ser Arg Leu Asp Gly Gln Trp Pro Asp Gly Leu Leu Ala Ser Asp Asn 
305                 310                 315                 320 


Thr Leu His Phe Val His Pro Leu Thr Phe Asn Tyr Ser Gly Val Tyr 
                325                 330                 335     


Ile Cys Lys Val Thr Asn Ser Leu Gly Gln Arg Ser Asp Gln Lys Val 
            340                 345                 350         


Ile Tyr Ile Ser Asp Pro Pro Thr Thr Thr Thr Leu Gln Pro Thr Ile 
        355                 360                 365             


Gln Trp His Pro Ser Thr Ala Asp Ile Glu Asp Leu Ala Thr Glu Pro 
    370                 375                 380                 


Lys Lys Leu Pro Phe Pro Leu Ser Thr Leu Ala Thr Ile Lys Asp Asp 
385                 390                 395                 400 


Thr Ile Ala Thr Ile Ile Ala Ser Val Val Gly Gly Ala Leu Phe Ile 
                405                 410                 415     


Val Leu Val Ser Val Leu Ala Gly Ile Phe Cys Tyr Arg Arg Arg Arg 
            420                 425                 430         


Thr Phe Arg Gly Asp Tyr Phe Ala Lys Asn Tyr Ile Pro Pro Ser Asp 
        435                 440                 445             


Met Gln Lys Glu Ser Gln Ile Asp Val Leu Gln Gln Asp Glu Leu Asp 
    450                 455                 460                 


Ser Tyr Pro Asp Ser Val Lys Lys Glu Asn Lys Asn Pro Val Asn Asn 
465                 470                 475                 480 


Leu Ile Arg Lys Asp Tyr Leu Glu Glu Pro Glu Lys Thr Gln Trp Asn 
                485                 490                 495     


Asn Val Glu Asn Leu Asn Arg Phe Glu Arg Pro Met Asp Tyr Tyr Glu 
            500                 505                 510         


Asp Leu Lys Met Gly Met Lys Phe Val Ser Asp Glu His Tyr Asp Glu 
        515                 520                 525             


Asn Glu Asp Asp Leu Val Ser His Val Asp Gly Ser Val Ile Ser Arg 
    530                 535                 540                 


Arg Glu Trp Tyr Val 
545                 


<210>  48
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Arg Thr Leu Arg Pro Ser Pro Leu Cys Pro Gly Gly Gly Lys 
1               5                   10                  15      


Ala Gln Leu Ser Ser Ala Ser Leu Leu Gly Ala Gly Leu Leu Leu Gln 
            20                  25                  30          


Pro Pro Thr Pro Pro Pro Leu Leu Leu Leu Leu Phe Pro Leu Leu Leu 
        35                  40                  45              


Phe Ser Arg Leu Cys Gly Ala Leu Ala Gly Pro Ile Ile Val Glu Pro 
    50                  55                  60                  


His Val Thr Ala Val Trp Gly Lys Asn Val Ser Leu Lys Cys Leu Ile 
65                  70                  75                  80  


Glu Val Asn Glu Thr Ile Thr Gln Ile Ser Trp Glu Lys Ile His Gly 
                85                  90                  95      


Lys Ser Ser Gln Thr Val Ala Val His His Pro Gln Tyr Gly Phe Ser 
            100                 105                 110         


Val Gln Gly Glu Tyr Gln Gly Arg Val Leu Phe Lys Asn Tyr Ser Leu 
        115                 120                 125             


Asn Asp Ala Thr Ile Thr Leu His Asn Ile Gly Phe Ser Asp Ser Gly 
    130                 135                 140                 


Lys Tyr Ile Cys Lys Ala Val Thr Phe Pro Leu Gly Asn Ala Gln Ser 
145                 150                 155                 160 


Ser Thr Thr Val Thr Val Leu Val Glu Pro Thr Val Ser Leu Ile Lys 
                165                 170                 175     


Gly Pro Asp Ser Leu Ile Asp Gly Gly Asn Glu Thr Val Ala Ala Ile 
            180                 185                 190         


Cys Ile Ala Ala Thr Gly Lys Pro Val Ala His Ile Asp Trp Glu Gly 
        195                 200                 205             


Asp Leu Gly Glu Met Glu Ser Thr Thr Thr Ser Phe Pro Asn Glu Thr 
    210                 215                 220                 


Ala Thr Ile Ile Ser Gln Tyr Lys Leu Phe Pro Thr Arg Phe Ala Arg 
225                 230                 235                 240 


Gly Arg Arg Ile Thr Cys Val Val Lys His Pro Ala Leu Glu Lys Asp 
                245                 250                 255     


Ile Arg Tyr Ser Phe Ile Leu Asp Ile Gln Tyr Ala Pro Glu Val Ser 
            260                 265                 270         


Val Thr Gly Tyr Asp Gly Asn Trp Phe Val Gly Arg Lys Gly Val Asn 
        275                 280                 285             


Leu Lys Cys Asn Ala Asp Ala Asn Pro Pro Pro Phe Lys Ser Val Trp 
    290                 295                 300                 


Ser Arg Leu Asp Gly Gln Trp Pro Asp Gly Leu Leu Ala Ser Asp Asn 
305                 310                 315                 320 


Thr Leu His Phe Val His Pro Leu Thr Phe Asn Tyr Ser Gly Val Tyr 
                325                 330                 335     


Ile Cys Lys Val Thr Asn Ser Leu Gly Gln Arg Ser Asp Gln Lys Val 
            340                 345                 350         


Ile Tyr Ile Ser Ala Tyr Asn Ser Val Ala Ser Leu Asn Cys 
        355                 360                 365     


<210>  49
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Glu Gly Trp Arg Trp Cys Phe Val Arg Arg Thr Pro Gly Leu 
1               5                   10                  15      


Leu Arg Gly Pro Leu Leu Pro Arg Ser Phe Ser Gly Asn Pro Arg Ala 
            20                  25                  30          


Leu Ala Gly Pro Ile Ile Val Glu Pro His Val Thr Ala Val Trp Gly 
        35                  40                  45              


Lys Asn Val Ser Leu Lys Cys Leu Ile Glu Val Asn Glu Thr Ile Thr 
    50                  55                  60                  


Gln Ile Ser Trp Glu Lys Ile His Gly Lys Ser Ser Gln Thr Val Ala 
65                  70                  75                  80  


Val His His Pro Gln Tyr Gly Phe Ser Val Gln Gly Glu Tyr Gln Gly 
                85                  90                  95      


Arg Val Leu Phe Lys Asn Tyr Ser Leu Asn Asp Ala Thr Ile Thr Leu 
            100                 105                 110         


His Asn Ile Gly Phe Ser Asp Ser Gly Lys Tyr Ile Cys Lys Ala Val 
        115                 120                 125             


Thr Phe Pro Leu Gly Asn Ala Gln Ser Ser Thr Thr Val Thr Val Leu 
    130                 135                 140                 


Val Glu Pro Thr Val Ser Leu Ile Lys Gly Pro Asp Ser Leu Ile Asp 
145                 150                 155                 160 


Gly Gly Asn Glu Thr Val Ala Ala Ile Cys Ile Ala Ala Thr Gly Lys 
                165                 170                 175     


Pro Val Ala His Ile Asp Trp Glu Gly Asp Leu Gly Glu Met Glu Ser 
            180                 185                 190         


Thr Thr Thr Ser Phe Pro Asn Glu Thr Ala Thr Ile Ile Ser Gln Tyr 
        195                 200                 205             


Lys Leu Phe Pro Thr Arg Phe Ala Arg Gly Arg Arg Ile Thr Cys Val 
    210                 215                 220                 


Val Lys His Pro Ala Leu Glu Lys Asp Ile Arg Tyr Ser Phe Ile Leu 
225                 230                 235                 240 


Asp Ile Gln Tyr Ala Pro Glu Val Ser Val Thr Gly Tyr Asp Gly Asn 
                245                 250                 255     


Trp Phe Val Gly Arg Lys Gly Val Asn Leu Lys Cys Asn Ala Asp Ala 
            260                 265                 270         


Asn Pro Pro Pro Phe Lys Ser Val Trp Ser Arg Leu Asp Gly Gln Trp 
        275                 280                 285             


Pro Asp Gly Leu Leu Ala Ser Asp Asn Thr Leu His Phe Val His Pro 
    290                 295                 300                 


Leu Thr Phe Asn Tyr Ser Gly Val Tyr Ile Cys Lys Val Thr Asn Ser 
305                 310                 315                 320 


Leu Gly Gln Arg Ser Asp Gln Lys Val Ile Tyr Ile Ser Asp Val Pro 
                325                 330                 335     


Phe Lys Gln Thr Ser Ser Ile Ala Val Ala Gly Ala Val Ile Gly Ala 
            340                 345                 350         


Val Leu Ala Leu Phe Ile Ile Ala Ile Phe Val Thr Val Leu Leu Thr 
        355                 360                 365             


Pro Arg Lys Lys Arg Pro Ser Tyr Leu Asp Lys Val Ile Asp Leu Pro 
    370                 375                 380                 


Pro Thr His Lys Pro Pro Pro Leu Tyr Glu Glu Arg Ser Pro Pro Leu 
385                 390                 395                 400 


Pro Gln Lys Asp Leu Phe Gln Pro Glu His Leu Pro Leu Gln Thr Gln 
                405                 410                 415     


Phe Lys Glu Arg Glu Val Gly Asn Leu Gln His Ser Asn Gly Leu Asn 
            420                 425                 430         


Ser Arg Ser Phe Asp Tyr Glu Asp Glu Asn Pro Val Gly Glu Asp Gly 
        435                 440                 445             


Ile Gln Gln Met Tyr Pro Leu Tyr Asn Gln Met Cys Tyr Gln Asp Arg 
    450                 455                 460                 


Ser Pro Gly Lys His His Gln Asn Asn Asp Pro Lys Arg Val Tyr Ile 
465                 470                 475                 480 


Asp Pro Arg Glu His Tyr Val 
                485         


<210>  50
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His 
1               5                   10                  15      


Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly 
            20                  25                  30          


Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys 
        35                  40                  45              


Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr 
    50                  55                  60                  


Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile 
65                  70                  75                  80  


Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu 
                85                  90                  95      


Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu 
            100                 105                 110         


Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr 
        115                 120                 125             


Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg 
    130                 135                 140                 


Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu 
145                 150                 155                 160 


Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala 
                165                 170                 175     


Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu 
            180                 185                 190         


Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu 
        195                 200                 205             


Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu 
    210                 215                 220                 


Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn 
225                 230                 235                 240 


Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser 
                245                 250                 255     


Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn 
            260                 265                 270         


Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu 
        275                 280                 285             


Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg 
    290                 295                 300                 


Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro 
305                 310                 315                 320 


Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser 
                325                 330                 335     


Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val 
            340                 345                 350         


Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala 
        355                 360                 365             


Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu 
    370                 375                 380                 


Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser 
385                 390                 395                 400 


Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn 
                405                 410                 415     


Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp 
            420                 425                 430         


Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys 
        435                 440                 445             


Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala 
    450                 455                 460                 


Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr 
465                 470                 475                 480 


Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp 
                485                 490                 495     


Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly 
            500                 505                 510         


Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser 
        515                 520                 525             


Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys 
    530                 535                 540                 


Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp 
545                 550                 555                 560 


Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu 
                565                 570                 575     


Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile 
            580                 585                 590         


Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala 
        595                 600                 605             


Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu 
    610                 615                 620                 


Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser 
625                 630                 635                 640 


Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr 
                645                 650                 655     


Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys 
            660                 665                 670         


Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe 
        675                 680                 685             


Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr 
    690                 695                 700                 


Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro 
705                 710                 715                 720 


Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile 
                725                 730                 735     


Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys 
            740                 745                 750         


Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp 
        755                 760                 765             


Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala 
    770                 775                 780                 


Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Gln Gln 
785                 790                 795                 800 


Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Lys Gly 
                805                 810                 815     


Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met Val Ile 
            820                 825                 830         


Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val Ile Ser 
        835                 840                 845             


Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr Ser Ala Pro 
    850                 855                 860                 


Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln Arg Val Thr Gly 
865                 870                 875                 880 


Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe Met Ala Pro Ile 
                885                 890                 895     


Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met 
            900                 905                 910         


Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu 
        915                 920                 925             


Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His 
    930                 935                 940                 


Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys 
945                 950                 955                 960 


Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe 
                965                 970                 975     


Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr 
            980                 985                 990         


Leu Phe Ser Gln His Asp Leu Ser  Phe Leu Asp Asp Val  Ile Pro Glu 
        995                 1000                 1005             


Lys Asp  Lys Lys Lys Lys Glu  Asp Glu Lys Lys Lys  Lys Lys Lys 
    1010                 1015                 1020             


Lys Gly  Ser Leu Asp Ser Asp  Asn Asp Asp Ser Asp  Cys Pro Tyr 
    1025                 1030                 1035             


Ser Glu  Lys Val Pro Ser Ile  Lys Ile Pro Met Asp  Ile Met Glu 
    1040                 1045                 1050             


Gln Gln  Pro Phe Leu Ser Asp  Ser Lys Pro Ser Asp  Arg Glu Arg 
    1055                 1060                 1065             


Ser Pro  Thr Phe Leu Glu Arg  His Thr Ser Cys 
    1070                 1075                 


<210>  51
<211>  1094
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His 
1               5                   10                  15      


Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly 
            20                  25                  30          


Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys 
        35                  40                  45              


Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr 
    50                  55                  60                  


Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile 
65                  70                  75                  80  


Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu 
                85                  90                  95      


Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu 
            100                 105                 110         


Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr 
        115                 120                 125             


Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg 
    130                 135                 140                 


Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu 
145                 150                 155                 160 


Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala 
                165                 170                 175     


Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu 
            180                 185                 190         


Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu 
        195                 200                 205             


Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu 
    210                 215                 220                 


Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn 
225                 230                 235                 240 


Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser 
                245                 250                 255     


Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn 
            260                 265                 270         


Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu 
        275                 280                 285             


Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg 
    290                 295                 300                 


Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro 
305                 310                 315                 320 


Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser 
                325                 330                 335     


Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val 
            340                 345                 350         


Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala 
        355                 360                 365             


Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu 
    370                 375                 380                 


Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser 
385                 390                 395                 400 


Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn 
                405                 410                 415     


Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp 
            420                 425                 430         


Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys 
        435                 440                 445             


Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala 
    450                 455                 460                 


Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr 
465                 470                 475                 480 


Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp 
                485                 490                 495     


Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly 
            500                 505                 510         


Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser 
        515                 520                 525             


Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys 
    530                 535                 540                 


Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp 
545                 550                 555                 560 


Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu 
                565                 570                 575     


Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile 
            580                 585                 590         


Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala 
        595                 600                 605             


Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu 
    610                 615                 620                 


Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser 
625                 630                 635                 640 


Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr 
                645                 650                 655     


Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys 
            660                 665                 670         


Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe 
        675                 680                 685             


Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr 
    690                 695                 700                 


Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro 
705                 710                 715                 720 


Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile 
                725                 730                 735     


Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys 
            740                 745                 750         


Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp 
        755                 760                 765             


Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala 
    770                 775                 780                 


Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Gln Gln 
785                 790                 795                 800 


Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Lys Gly 
                805                 810                 815     


Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met Val Ile 
            820                 825                 830         


Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val Ile Ser 
        835                 840                 845             


Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr Ser Ala Pro 
    850                 855                 860                 


Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln Arg Val Thr Gly 
865                 870                 875                 880 


Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe Met Ala Pro Ile 
                885                 890                 895     


Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met 
            900                 905                 910         


Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu 
        915                 920                 925             


Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His 
    930                 935                 940                 


Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys 
945                 950                 955                 960 


Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe 
                965                 970                 975     


Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr 
            980                 985                 990         


Leu Phe Ser Gln His Asp Leu Ser  Phe Leu Asp Asp Val  Ile Pro Glu 
        995                 1000                 1005             


Lys Asp  Lys Lys Lys Lys Glu  Asp Glu Lys Lys Lys  Lys Lys Lys 
    1010                 1015                 1020             


Lys Gly  Ser Leu Asp Ser Asp  Asn Asp Asp Glu Lys  Asp His Gln 
    1025                 1030                 1035             


His Ser  Leu Asn Ala Thr His  His Ala Asp Lys Ile  Pro Phe Leu 
    1040                 1045                 1050             


Gln Ser  Leu Gly Met Pro Ser  Pro Pro Arg Thr Pro  Val Lys Val 
    1055                 1060                 1065             


Val Pro  Gln Ile Arg Ile Glu  Leu Glu Pro Glu Asp  Asn Asp Tyr 
    1070                 1075                 1080             


Phe Trp  Arg Ser Lys Gly Thr  Glu Thr Thr Leu 
    1085                 1090                 


<210>  52
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Thr Glu Asn Val Glu Gly Lys Pro Ser Asn Leu Gly Glu Arg 
1               5                   10                  15      


Gly Arg Ala Arg Ser Ser Thr Phe Leu Arg Val Val Gln Pro Met Phe 
            20                  25                  30          


Asn His Ser Ile Phe Thr Ser Ala Val Ser Pro Ala Ala Glu Arg Ile 
        35                  40                  45              


Arg Phe Ile Leu Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu 
    50                  55                  60                  


Phe Thr Glu Leu Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu 
65                  70                  75                  80  


Trp Lys Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln 
                85                  90                  95      


Gly Gly Glu Arg Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His 
            100                 105                 110         


Ser Leu Phe Glu Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu 
        115                 120                 125             


Asp Arg Glu Ala Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp 
    130                 135                 140                 


His Gln Ile Glu Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val 
145                 150                 155                 160 


Thr Tyr Thr Leu Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn 
                165                 170                 175     


Leu Arg Ser Leu Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg 
            180                 185                 190         


Met Phe Thr Asn Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn 
        195                 200                 205             


Leu Thr Ser Ser Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp 
    210                 215                 220                 


Gln Leu Lys Asn Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala 
225                 230                 235                 240 


Ser Asn Val Leu Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile 
                245                 250                 255     


Ala Phe Val Arg Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu 
            260                 265                 270         


Val Pro Val Pro Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly 
        275                 280                 285             


Lys Ala Lys Ser Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met 
    290                 295                 300                 


Ser Asp Glu Val Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His 
305                 310                 315                 320 


Asp Leu Ile Ala Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu 
                325                 330                 335     


Pro Pro Gly Glu Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser 
            340                 345                 350         


Leu Pro Ser Ser Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn 
        355                 360                 365             


Val Gln Met Asn Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly 
    370                 375                 380                 


Gly His Gly Asp Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly 
385                 390                 395                 400 


Gly Leu Ile Lys Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp 
                405                 410                 415     


Phe Tyr Asp Ala Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile 
            420                 425                 430         


Tyr Leu Ala Thr Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly 
        435                 440                 445             


Asp Ala Thr Asp Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr 
    450                 455                 460                 


Ala Val Ser Gly Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr 
465                 470                 475                 480 


Ile Leu Ser Ser Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe 
                485                 490                 495     


Asn Phe Ser Lys Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp 
            500                 505                 510         


Ile Gly Leu Trp Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp 
        515                 520                 525             


Ala Ser Phe Leu Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe 
    530                 535                 540                 


Ser Ser Leu Ile Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met 
545                 550                 555                 560 


Ile Lys Leu Ala Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly 
                565                 570                 575     


Tyr Asn Thr Leu Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn 
            580                 585                 590         


Ile Ser Ile Ser Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr 
        595                 600                 605             


Met Ser Ser Thr Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe 
    610                 615                 620                 


Leu Ser Lys Lys Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn 
625                 630                 635                 640 


Asn Cys Asn Phe Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe 
                645                 650                 655     


Leu Gly Thr Tyr Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser 
            660                 665                 670         


Pro Tyr Phe Pro Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile 
        675                 680                 685             


Ile Leu Ser Ile Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val 
    690                 695                 700                 


Asp Thr Pro Lys Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro 
705                 710                 715                 720 


Asn Arg Gly Trp Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val 
                725                 730                 735     


Cys Leu Ala Ala Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe 
            740                 745                 750         


Met Asp Gln Gln Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys 
        755                 760                 765             


Leu Lys Lys Gly Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile 
    770                 775                 780                 


Leu Met Val Ile Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala 
785                 790                 795                 800 


Thr Val Ile Ser Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu 
                805                 810                 815     


Thr Ser Ala Pro Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln 
            820                 825                 830         


Arg Val Thr Gly Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe 
        835                 840                 845             


Met Ala Pro Ile Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val 
    850                 855                 860                 


Phe Leu Tyr Met Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp 
865                 870                 875                 880 


Arg Leu Lys Leu Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile 
                885                 890                 895     


Tyr Leu Arg His Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu 
            900                 905                 910         


Gln Val Leu Cys Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala 
        915                 920                 925             


Ala Ile Ile Phe Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys 
    930                 935                 940                 


Gly Met Asp Tyr Leu Phe Ser Gln His Asp Leu Ser Phe Leu Asp Asp 
945                 950                 955                 960 


Val Ile Pro Glu Lys Asp Lys Lys Lys Lys Glu Asp Glu Lys Lys Lys 
                965                 970                 975     


Lys Lys Lys Lys Gly Ser Leu Asp Ser Asp Asn Asp Asp Ser Asp Cys 
            980                 985                 990         


Pro Tyr Ser Glu Lys Val Pro Ser  Ile Lys Ile Pro Met  Asp Ile Met 
        995                 1000                 1005             


Glu Gln  Gln Pro Phe Leu Ser  Asp Ser Lys Pro Ser  Asp Arg Glu 
    1010                 1015                 1020             


Arg Ser  Pro Thr Phe Leu Glu  Arg His Thr Ser Cys  
    1025                 1030                 1035 


<210>  53
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Val Lys Pro Ser Gly Ala 
    130                 135                 140                 


Arg Cys Tyr Val Asp Gly Ser Glu Glu Ile Gly Ser Asp Phe Lys Ile 
145                 150                 155                 160 


Lys Cys Glu Pro Lys Glu Gly Ser Leu Pro Leu Gln Tyr Glu Trp Gln 
                165                 170                 175     


Lys Leu Ser Asp Ser Gln Lys Met Pro Thr Ser Trp Leu Ala Glu Met 
            180                 185                 190         


Thr Ser Ser Val Ile Ser Val Lys Asn Ala Ser Ser Glu Tyr Ser Gly 
        195                 200                 205             


Thr Tyr Ser Cys Thr Val Arg Asn Arg Val Gly Ser Asp Gln Cys Leu 
    210                 215                 220                 


Leu Arg Leu Asn Val Val Pro Pro Ser Asn Lys Ala Gly Leu Ile Ala 
225                 230                 235                 240 


Gly Ala Ile Ile Gly Thr Leu Leu Ala Leu Ala Leu Ile Gly Leu Ile 
                245                 250                 255     


Ile Phe Cys Cys Arg Lys Lys Arg Arg Glu Glu Lys Tyr Glu Lys Glu 
            260                 265                 270         


Val His His Asp Ile Arg Glu Asp Val Pro Pro Pro Lys Ser Arg Thr 
        275                 280                 285             


Ser Thr Ala Arg Ser Tyr Ile Gly Ser Asn His Ser Ser Leu Gly Ser 
    290                 295                 300                 


Met Ser Pro Ser Asn Met Glu Gly Tyr Ser Lys Thr Gln Tyr Asn Gln 
305                 310                 315                 320 


Val Pro Ser Glu Asp Phe Glu Arg Thr Pro Gln Ser Pro Thr Leu Pro 
                325                 330                 335     


Pro Ala Lys Val Ala Ala Pro Asn Leu Ser Arg Met Gly Ala Ile Pro 
            340                 345                 350         


Val Met Ile Pro Ala Gln Ser Lys Asp Gly Ser Ile Val 
        355                 360                 365 


<210>  54
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Val Lys Pro Ser Gly Ala 
    130                 135                 140                 


Arg Cys Tyr Val Asp Gly Ser Glu Glu Ile Gly Ser Asp Phe Lys Ile 
145                 150                 155                 160 


Lys Cys Glu Pro Lys Glu Gly Ser Leu Pro Leu Gln Tyr Glu Trp Gln 
                165                 170                 175     


Lys Leu Ser Asp Ser Gln Lys Met Pro Thr Ser Trp Leu Ala Gly Lys 
            180                 185                 190         


Met Cys His Leu Gln Arg Ala Val Arg Pro Leu Pro Glu Ala Thr Ser 
        195                 200                 205             


Ala Val Ile Ile His Pro Trp Gly Pro Cys Leu Leu Pro Thr Trp Lys 
    210                 215                 220                 


Asp Ile Pro Arg Leu Ser Ile Thr Lys Tyr Gln Val Lys Thr Leu Asn 
225                 230                 235                 240 


Ala Leu Leu Arg Val Arg Leu Ser His Leu Leu Arg 
                245                 250         


<210>  55
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Gly Lys Met Cys His Leu 
    130                 135                 140                 


Gln Arg Ala Val Arg Pro Leu Pro Glu Ala Thr Ser Ala Val Ile Ile 
145                 150                 155                 160 


His Pro Trp Gly Pro Cys Leu Leu Pro Thr Trp Lys Asp Ile Pro Arg 
                165                 170                 175     


Leu Ser Ile Thr Lys Tyr Gln Val Lys Thr Leu Asn Ala Leu Leu Arg 
            180                 185                 190         


Val Arg Leu Ser His Leu Leu Arg 
        195                 200 


<210>  56
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Gly Arg Cys Ala Thr Ser Lys Glu Pro Tyr 
65                  70                  75                  80  


Val His Cys Gln Lys Leu His Arg Gln 
                85                  


<210>  57
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Val Lys Pro Ser Gly Ala 
    130                 135                 140                 


Arg Cys Tyr Val Asp Gly Ser Glu Glu Ile Gly Ser Asp Phe Lys Ile 
145                 150                 155                 160 


Lys Cys Glu Pro Lys Glu Gly Ser Leu Pro Leu Gln Tyr Glu Trp Gln 
                165                 170                 175     


Lys Leu Ser Asp Ser Gln Lys Met Pro Thr Ser Trp Leu Ala Glu Met 
            180                 185                 190         


Thr Ser Ser Val Ile Ser Val Lys Asn Ala Ser Ser Glu Tyr Ser Gly 
        195                 200                 205             


Thr Tyr Ser Cys Thr Val Arg Asn Arg Val Gly Ser Asp Gln Cys Leu 
    210                 215                 220                 


Leu Arg Leu Asn Val Val Pro Pro Ser Asn Lys Ala Gly Leu Ile Ala 
225                 230                 235                 240 


Gly Ala Ile Ile Gly Thr Leu Leu Ala Leu Ala Leu Ile Gly Leu Ile 
                245                 250                 255     


Ile Phe Cys Cys Arg Lys Lys Arg Arg Glu Glu Lys Tyr Glu Lys Glu 
            260                 265                 270         


Val His His Asp Ile Arg Glu Asp Val Pro Pro Pro Lys Ser Arg Thr 
        275                 280                 285             


Ser Thr Ala Arg Ser Tyr Ile Gly Ser Asn His Ser Ser Leu Gly Ser 
    290                 295                 300                 


Met Ser Pro Ser Asn Met Glu Gly Tyr Ser Lys Thr Gln Tyr Asn Gln 
305                 310                 315                 320 


Val Pro Ser Glu Asp Phe Glu Arg Thr Pro Gln Ser Pro Thr Leu Pro 
                325                 330                 335     


Pro Ala Lys Phe Lys Tyr Pro Tyr Lys Thr Asp Gly Ile Thr Val Val 
            340                 345                 350         


<210>  58
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gly Arg Ala Arg Arg Phe Gln Trp Pro Leu Leu Leu Leu Trp Ala 
1               5                   10                  15      


Ala Ala Ala Gly Pro Gly Ala Gly Gln Glu Val Gln Thr Glu Asn Val 
            20                  25                  30          


Thr Val Ala Glu Gly Gly Val Ala Glu Ile Thr Cys Arg Leu His Gln 
        35                  40                  45              


Tyr Asp Gly Ser Ile Val Val Ile Gln Asn Pro Ala Arg Gln Thr Leu 
    50                  55                  60                  


Phe Phe Asn Gly Thr Arg Ala Leu Lys Asp Glu Arg Phe Gln Leu Glu 
65                  70                  75                  80  


Glu Phe Ser Pro Arg Arg Val Arg Ile Arg Leu Ser Asp Ala Arg Leu 
                85                  90                  95      


Glu Asp Glu Gly Gly Tyr Phe Cys Gln Leu Tyr Thr Glu Asp Thr His 
            100                 105                 110         


His Gln Ile Ala Thr Leu Thr Val Leu Val Ala Pro Glu Asn Pro Val 
        115                 120                 125             


Val Glu Val Arg Glu Gln Ala Val Glu Gly Gly Glu Val Glu Leu Ser 
    130                 135                 140                 


Cys Leu Val Pro Arg Ser Arg Pro Ala Ala Thr Leu Arg Trp Tyr Arg 
145                 150                 155                 160 


Asp Arg Lys Glu Leu Lys Gly Val Ser Ser Ser Gln Glu Asn Gly Lys 
                165                 170                 175     


Val Trp Ser Val Ala Ser Thr Val Arg Phe Arg Val Asp Arg Lys Asp 
            180                 185                 190         


Asp Gly Gly Ile Ile Ile Cys Glu Ala Gln Asn Gln Ala Leu Pro Ser 
        195                 200                 205             


Gly His Ser Lys Gln Thr Gln Tyr Val Leu Asp Val Gln Tyr Ser Pro 
    210                 215                 220                 


Thr Ala Arg Ile His Ala Ser Gln Ala Val Val Arg Glu Gly Asp Thr 
225                 230                 235                 240 


Leu Val Leu Thr Cys Ala Val Thr Gly Asn Pro Arg Pro Asn Gln Ile 
                245                 250                 255     


Arg Trp Asn Arg Gly Asn Glu Ser Leu Pro Glu Arg Ala Glu Ala Val 
            260                 265                 270         


Gly Glu Thr Leu Thr Leu Pro Gly Leu Val Ser Ala Asp Asn Gly Thr 
        275                 280                 285             


Tyr Thr Cys Glu Ala Ser Asn Lys His Gly His Ala Arg Ala Leu Tyr 
    290                 295                 300                 


Val Leu Val Val Tyr Asp Pro Gly Ala Val Val Glu Ala Gln Thr Ser 
305                 310                 315                 320 


Val Pro Tyr Ala Ile Val Gly Gly Ile Leu Ala Leu Leu Val Phe Leu 
                325                 330                 335     


Ile Ile Cys Val Leu Val Gly Met Val Trp Cys Ser Val Arg Gln Lys 
            340                 345                 350         


Gly Ser Tyr Leu Thr His Glu Ala Ser Gly Leu Asp Glu Gln Gly Glu 
        355                 360                 365             


Ala Arg Glu Ala Phe Leu Asn Gly Ser Asp Gly His Lys Arg Lys Glu 
    370                 375                 380                 


Glu Phe Phe Ile 
385             


<210>  59
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Thr Gln Arg Ser Ile Ala Gly Pro Ile Cys Asn Leu Lys Phe Val 
1               5                   10                  15      


Thr Leu Leu Val Ala Leu Ser Ser Glu Leu Pro Phe Leu Gly Ala Gly 
            20                  25                  30          


Val Gln Leu Gln Asp Asn Gly Tyr Asn Gly Leu Leu Ile Ala Ile Asn 
        35                  40                  45              


Pro Gln Val Pro Glu Asn Gln Asn Leu Ile Ser Asn Ile Lys Glu Met 
    50                  55                  60                  


Ile Thr Glu Ala Ser Phe Tyr Leu Phe Asn Ala Thr Lys Arg Arg Val 
65                  70                  75                  80  


Phe Phe Arg Asn Ile Lys Ile Leu Ile Pro Ala Thr Trp Lys Ala Asn 
                85                  90                  95      


Asn Asn Ser Lys Ile Lys Gln Glu Ser Tyr Glu Lys Ala Asn Val Ile 
            100                 105                 110         


Val Thr Asp Trp Tyr Gly Ala His Gly Asp Asp Pro Tyr Thr Leu Gln 
        115                 120                 125             


Tyr Arg Gly Cys Gly Lys Glu Gly Lys Tyr Ile His Phe Thr Pro Asn 
    130                 135                 140                 


Phe Leu Leu Asn Asp Asn Leu Thr Ala Gly Tyr Gly Ser Arg Gly Arg 
145                 150                 155                 160 


Val Phe Val His Glu Trp Ala His Leu Arg Trp Gly Val Phe Asp Glu 
                165                 170                 175     


Tyr Asn Asn Asp Lys Pro Phe Tyr Ile Asn Gly Gln Asn Gln Ile Lys 
            180                 185                 190         


Val Thr Arg Cys Ser Ser Asp Ile Thr Gly Ile Phe Val Cys Glu Lys 
        195                 200                 205             


Gly Pro Cys Pro Gln Glu Asn Cys Ile Ile Ser Lys Leu Phe Lys Glu 
    210                 215                 220                 


Gly Cys Thr Phe Ile Tyr Asn Ser Thr Gln Asn Ala Thr Ala Ser Ile 
225                 230                 235                 240 


Met Phe Met Gln Ser Leu Ser Ser Val Val Glu Phe Cys Asn Ala Ser 
                245                 250                 255     


Thr His Asn Gln Glu Ala Pro Asn Leu Gln Asn Gln Met Cys Ser Leu 
            260                 265                 270         


Arg Ser Ala Trp Asp Val Ile Thr Asp Ser Ala Asp Phe His His Ser 
        275                 280                 285             


Phe Pro Met Asn Gly Thr Glu Leu Pro Pro Pro Pro Thr Phe Ser Leu 
    290                 295                 300                 


Val Gln Ala Gly Asp Lys Val Val Cys Leu Val Leu Asp Val Ser Ser 
305                 310                 315                 320 


Lys Met Ala Glu Ala Asp Arg Leu Leu Gln Leu Gln Gln Ala Ala Glu 
                325                 330                 335     


Phe Tyr Leu Met Gln Ile Val Glu Ile His Thr Phe Val Gly Ile Ala 
            340                 345                 350         


Ser Phe Asp Ser Lys Gly Glu Ile Arg Ala Gln Leu His Gln Ile Asn 
        355                 360                 365             


Ser Asn Asp Asp Arg Lys Leu Leu Val Ser Tyr Leu Pro Thr Thr Val 
    370                 375                 380                 


Ser Ala Lys Thr Asp Ile Ser Ile Cys Ser Gly Leu Lys Lys Gly Phe 
385                 390                 395                 400 


Glu Val Val Glu Lys Leu Asn Gly Lys Ala Tyr Gly Ser Val Met Ile 
                405                 410                 415     


Leu Val Thr Ser Gly Asp Asp Lys Leu Leu Gly Asn Cys Leu Pro Thr 
            420                 425                 430         


Val Leu Ser Ser Gly Ser Thr Ile His Ser Ile Ala Leu Gly Ser Ser 
        435                 440                 445             


Ala Ala Pro Asn Leu Glu Glu Leu Ser Arg Leu Thr Gly Gly Leu Lys 
    450                 455                 460                 


Phe Phe Val Pro Asp Ile Ser Asn Ser Asn Ser Met Ile Asp Ala Phe 
465                 470                 475                 480 


Ser Arg Ile Ser Ser Gly Thr Gly Asp Ile Phe Gln Gln His Ile Gln 
                485                 490                 495     


Leu Glu Ser Thr Gly Glu Asn Val Lys Pro His His Gln Leu Lys Asn 
            500                 505                 510         


Thr Val Thr Val Asp Asn Thr Val Gly Asn Asp Thr Met Phe Leu Val 
        515                 520                 525             


Thr Trp Gln Ala Ser Gly Pro Pro Glu Ile Ile Leu Phe Asp Pro Asp 
    530                 535                 540                 


Gly Arg Lys Tyr Tyr Thr Asn Asn Phe Ile Thr Asn Leu Thr Phe Arg 
545                 550                 555                 560 


Thr Ala Ser Leu Trp Ile Pro Gly Thr Ala Lys Pro Gly His Trp Thr 
                565                 570                 575     


Tyr Thr Leu Asn Asn Thr His His Ser Leu Gln Ala Leu Lys Val Thr 
            580                 585                 590         


Val Thr Ser Arg Ala Ser Asn Ser Ala Val Pro Pro Ala Thr Val Glu 
        595                 600                 605             


Ala Phe Val Glu Arg Asp Ser Leu His Phe Pro His Pro Val Met Ile 
    610                 615                 620                 


Tyr Ala Asn Val Lys Gln Gly Phe Tyr Pro Ile Leu Asn Ala Thr Val 
625                 630                 635                 640 


Thr Ala Thr Val Glu Pro Glu Thr Gly Asp Pro Val Thr Leu Arg Leu 
                645                 650                 655     


Leu Asp Asp Gly Ala Gly Ala Asp Val Ile Lys Asn Asp Gly Ile Tyr 
            660                 665                 670         


Ser Arg Tyr Phe Phe Ser Phe Ala Ala Asn Gly Arg Tyr Ser Leu Lys 
        675                 680                 685             


Val His Val Asn His Ser Pro Ser Ile Ser Thr Pro Ala His Ser Ile 
    690                 695                 700                 


Pro Gly Ser His Ala Met Tyr Val Pro Gly Tyr Thr Ala Asn Gly Asn 
705                 710                 715                 720 


Ile Gln Met Asn Ala Pro Arg Lys Ser Val Gly Arg Asn Glu Glu Glu 
                725                 730                 735     


Arg Lys Trp Gly Phe Ser Arg Val Ser Ser Gly Gly Ser Phe Ser Val 
            740                 745                 750         


Leu Gly Val Pro Ala Gly Pro His Pro Asp Val Phe Pro Pro Cys Lys 
        755                 760                 765             


Ile Ile Asp Leu Glu Ala Val Lys Val Glu Glu Glu Leu Thr Leu Ser 
    770                 775                 780                 


Trp Thr Ala Pro Gly Glu Asp Phe Asp Gln Gly Gln Ala Thr Ser Tyr 
785                 790                 795                 800 


Glu Ile Arg Met Ser Lys Ser Leu Gln Asn Ile Gln Asp Asp Phe Asn 
                805                 810                 815     


Asn Ala Ile Leu Val Asn Thr Ser Lys Arg Asn Pro Gln Gln Ala Gly 
            820                 825                 830         


Ile Arg Glu Ile Phe Thr Phe Ser Pro Gln Ile Ser Thr Asn Gly Pro 
        835                 840                 845             


Glu His Gln Pro Asn Gly Glu Thr His Glu Ser His Arg Ile Tyr Val 
    850                 855                 860                 


Ala Ile Arg Ala Met Asp Arg Asn Ser Leu Gln Ser Ala Val Ser Asn 
865                 870                 875                 880 


Ile Ala Gln Ala Pro Leu Phe Ile Pro Pro Asn Ser Asp Pro Val Pro 
                885                 890                 895     


Ala Arg Asp Tyr Leu Ile Leu Lys Gly Val Leu Thr Ala Met Gly Leu 
            900                 905                 910         


Ile Gly Ile Ile Cys Leu Ile Ile Val Val Thr His His Thr Leu Ser 
        915                 920                 925             


Arg Lys Lys Arg Ala Asp Lys Lys Glu Asn Gly Thr Lys Leu Leu 
    930                 935                 940             


<210>  60
<211>  540
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser 
65                  70                  75                  80  


Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu 
                85                  90                  95      


Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro 
            100                 105                 110         


Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu 
        115                 120                 125             


Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser 
    130                 135                 140                 


Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp 
145                 150                 155                 160 


Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn 
                165                 170                 175     


Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro 
            180                 185                 190         


Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu 
        195                 200                 205             


Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg 
    210                 215                 220                 


Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Glu Ala 
225                 230                 235                 240 


Met Ser Arg Phe Cys Glu Ala Glu Phe Ser Val Lys Thr Arg Pro His 
                245                 250                 255     


Trp Cys Cys Thr Arg Gln Gly Glu Ala Arg Phe Ser Cys Phe Gln Glu 
            260                 265                 270         


Glu Ala Pro Gln Pro His Tyr Gln Leu Arg Ala Cys Pro Ser His Gln 
        275                 280                 285             


Pro Asp Ile Ser Ser Gly Leu Glu Leu Pro Phe Pro Pro Gly Val Pro 
    290                 295                 300                 


Thr Leu Asp Asn Ile Lys Asn Ile Cys His Leu Arg Arg Phe Arg Ser 
305                 310                 315                 320 


Val Pro Arg Asn Leu Pro Ala Thr Asp Pro Leu Gln Arg Glu Leu Leu 
                325                 330                 335     


Ala Leu Ile Gln Leu Glu Arg Glu Phe Gln Arg Cys Cys Arg Gln Gly 
            340                 345                 350         


Asn Asn His Thr Cys Thr Trp Lys Ala Trp Glu Asp Thr Leu Asp Lys 
        355                 360                 365             


Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His Leu Cys Cys 
    370                 375                 380                 


Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala Arg Arg Ala 
385                 390                 395                 400 


Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp Ile Gly Arg 
                405                 410                 415     


Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln Arg Val Leu 
            420                 425                 430         


Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg 
        435                 440                 445             


Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala Glu Glu Glu 
    450                 455                 460                 


Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg Asn Ile Trp 
465                 470                 475                 480 


Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp Glu Gln Val 
                485                 490                 495     


Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu Val Ser Gly 
            500                 505                 510         


Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly 
        515                 520                 525             


Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu 
    530                 535                 540 


<210>  61
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gln Val Gln Pro Pro Pro Ser 
65                  70                  75                  80  


Gln Glu Ala Thr Pro Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu 
                85                  90                  95      


Pro Ala Glu Lys Glu Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro 
            100                 105                 110         


Leu Gln Lys Glu Leu Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu 
        115                 120                 125             


Gly Thr Pro Ala Pro Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser 
    130                 135                 140                 


Trp Asn Ala Ala Gln His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp 
145                 150                 155                 160 


Gly His Arg Leu Asp Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn 
                165                 170                 175     


Leu Asn Gln Ile Cys Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro 
            180                 185                 190         


Trp Asn Leu Pro Gln Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu 
        195                 200                 205             


Thr Leu Asn Phe Leu Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg 
    210                 215                 220                 


Ser His Thr Asn Arg Leu Glu Cys Ala Lys Leu Val Trp Glu Asp Thr 
225                 230                 235                 240 


Leu Asp Lys Tyr Cys Asp Arg Glu Tyr Ala Val Lys Thr His His His 
                245                 250                 255     


Leu Cys Cys Arg His Pro Pro Ser Pro Thr Arg Asp Glu Cys Phe Ala 
            260                 265                 270         


Arg Arg Ala Pro Tyr Pro Asn Tyr Asp Arg Asp Ile Leu Thr Ile Asp 
        275                 280                 285             


Ile Gly Arg Val Thr Pro Asn Leu Met Gly His Leu Cys Gly Asn Gln 
    290                 295                 300                 


Arg Val Leu Thr Lys His Lys His Ile Pro Gly Leu Ile His Asn Met 
305                 310                 315                 320 


Thr Ala Arg Cys Cys Asp Leu Pro Phe Pro Glu Gln Ala Cys Cys Ala 
                325                 330                 335     


Glu Glu Glu Lys Leu Thr Phe Ile Asn Asp Leu Cys Gly Pro Arg Arg 
            340                 345                 350         


Asn Ile Trp Arg Asp Pro Ala Leu Cys Cys Tyr Leu Ser Pro Gly Asp 
        355                 360                 365             


Glu Gln Val Asn Cys Phe Asn Ile Asn Tyr Leu Arg Asn Val Ala Leu 
    370                 375                 380                 


Val Ser Gly Asp Thr Glu Asn Ala Lys Gly Gln Gly Glu Gln Gly Ser 
385                 390                 395                 400 


Thr Gly Gly Thr Asn Ile Ser Ser Thr Ser Glu Pro Lys Glu Glu 
                405                 410                 415 


<210>  62
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gly Thr Thr Ala Arg Ala Ala Leu Val Leu Thr Tyr Leu Ala Val 
1               5                   10                  15      


Ala Ser Ala Ala Ser Glu Gly Gly Phe Thr Ala Thr Gly Gln Arg Gln 
            20                  25                  30          


Leu Arg Pro Glu His Phe Gln Glu Val Gly Tyr Ala Ala Pro Pro Ser 
        35                  40                  45              


Pro Pro Leu Ser Arg Ser Leu Pro Met Asp His Pro Asp Ser Ser Gln 
    50                  55                  60                  


His Gly Pro Pro Phe Glu Gly Gln Ser Gly Lys Glu Gly Arg Gly Pro 
65                  70                  75                  80  


Arg Pro His Ser Gln Pro Trp Leu Gly Glu Arg Val Gly Cys Ser His 
                85                  90                  95      


Ile Pro Pro Ser Ile Val Gln Pro Pro Pro Ser Gln Glu Ala Thr Pro 
            100                 105                 110         


Leu Gln Gln Glu Lys Leu Leu Pro Ala Gln Leu Pro Ala Glu Lys Glu 
        115                 120                 125             


Val Gly Pro Pro Leu Pro Gln Glu Ala Val Pro Leu Gln Lys Glu Leu 
    130                 135                 140                 


Pro Ser Leu Gln His Pro Asn Glu Gln Lys Glu Gly Thr Pro Ala Pro 
145                 150                 155                 160 


Phe Gly Asp Gln Ser His Pro Glu Pro Glu Ser Trp Asn Ala Ala Gln 
                165                 170                 175     


His Cys Gln Gln Asp Arg Ser Gln Gly Gly Trp Gly His Arg Leu Asp 
            180                 185                 190         


Gly Phe Pro Pro Gly Arg Pro Ser Pro Asp Asn Leu Asn Gln Ile Cys 
        195                 200                 205             


Leu Pro Asn Arg Gln His Val Val Tyr Gly Pro Trp Asn Leu Pro Gln 
    210                 215                 220                 


Ser Ser Tyr Ser His Leu Thr Arg Gln Gly Glu Thr Leu Asn Phe Leu 
225                 230                 235                 240 


Glu Ile Gly Tyr Ser Arg Cys Cys His Cys Arg Ser His Thr Asn Arg 
                245                 250                 255     


Leu Glu Cys Ala Lys Leu Val Trp Glu Glu Ala Met Ser Arg Phe Cys 
            260                 265                 270         


Glu Ala Glu Phe Ser Val Lys Thr Arg Pro His Trp Cys Cys Thr Arg 
        275                 280                 285             


Gln Gly Glu Ala Arg Phe Ser Cys Phe Gln Glu Glu Ala Pro Gln Pro 
    290                 295                 300                 


His Tyr Gln Leu Arg Ala Cys Pro Ser His Gln Pro Asp Ile Ser Ser 
305                 310                 315                 320 


Gly Leu Glu Leu Pro Phe Pro Pro Gly Val Pro Thr Leu Asp Asn Ile 
                325                 330                 335     


Lys Asn Ile Cys His Leu Arg Arg Phe Arg Ser Val Pro Arg Asn Leu 
            340                 345                 350         


Pro Ala Thr Asp Pro Leu Gln Arg Glu Leu Leu Ala Leu Ile Gln Leu 
        355                 360                 365             


Glu Arg Glu Phe Gln Arg Cys Cys Arg Gln Gly Asn Asn His Thr Cys 
    370                 375                 380                 


Thr Trp Lys Ala Trp Glu Asp Thr Leu Asp Lys Tyr Cys Asp Arg Glu 
385                 390                 395                 400 


Tyr Ala Val Lys Thr His His His Leu Cys Cys Arg His Pro Pro Ser 
                405                 410                 415     


Pro Thr Arg Asp Glu Cys Phe Ala Arg Arg Ala Pro Tyr Pro Asn Tyr 
            420                 425                 430         


Asp Arg Asp Ile Leu Thr Ile Asp Ile Gly Arg Val Thr Pro Asn Leu 
        435                 440                 445             


Met Gly His Leu Cys Gly Asn Gln Arg Val Leu Thr Lys His Lys His 
    450                 455                 460                 


Ile Pro Gly Leu Ile His Asn Met Thr Ala Arg Cys Cys Asp Leu Pro 
465                 470                 475                 480 


Phe Pro Glu Gln Ala Cys Cys Ala Glu Glu Glu Lys Leu Thr Phe Ile 
                485                 490                 495     


Asn Asp Leu Cys Gly Pro Arg Arg Asn Ile Trp Arg Asp Pro Ala Leu 
            500                 505                 510         


Cys Cys Tyr Leu Ser Pro Gly Asp Glu Gln Val Asn Cys Phe Asn Ile 
        515                 520                 525             


Asn Tyr Leu Arg Asn Val Ala Leu Val Ser Gly Asp Thr Glu Asn Ala 
    530                 535                 540                 


Lys Gly Gln Gly Glu Gln Gly Ser Thr Gly Gly Thr Asn Ile Ser Ser 
545                 550                 555                 560 


Thr Ser Glu Pro Lys Glu Glu 
                565         


<210>  63
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Asn Ala Gly Leu Gln Leu Leu Gly Phe Ile Leu Ala Phe Leu 
1               5                   10                  15      


Gly Trp Ile Gly Ala Ile Val Ser Thr Ala Leu Pro Gln Trp Arg Ile 
            20                  25                  30          


Tyr Ser Tyr Ala Gly Asp Asn Ile Val Thr Ala Gln Ala Met Tyr Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Ser Gln Ser Thr Gly Gln Ile Gln Cys 
    50                  55                  60                  


Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Gly Ile Leu Leu Gly Val Ile Ala Ile Phe 
                85                  90                  95      


Val Ala Thr Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu 
            100                 105                 110         


Val Gln Lys Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu 
        115                 120                 125             


Ala Gly Leu Ala Ile Leu Val Ala Thr Ala Trp Tyr Gly Asn Arg Ile 
    130                 135                 140                 


Val Gln Glu Phe Tyr Asp Pro Met Thr Pro Val Asn Ala Arg Tyr Glu 
145                 150                 155                 160 


Phe Gly Gln Ala Leu Phe Thr Gly Trp Ala Ala Ala Ser Leu Cys Leu 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Cys Cys Ser Cys Pro Arg Lys Thr Thr Ser 
            180                 185                 190         


Tyr Pro Thr Pro Arg Pro Tyr Pro Lys Pro Ala Pro Ser Ser Gly Lys 
        195                 200                 205             


Asp Tyr Val 
    210     


<210>  64
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Glu Arg Ala Ser Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Glu Asp Met Ala Ala Phe Met Lys Gly Ala Val Glu Lys 
            20                  25                  30          


Gly Glu Glu Leu Ser Cys Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Gln Arg Ala Ala Trp Arg Val Leu Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Ser Asn Glu Glu Gly Ser Glu Glu Lys Gly Pro Glu 
65                  70                  75                  80  


Val Arg Glu Tyr Arg Glu Lys Val Glu Thr Glu Leu Gln Gly Val Cys 
                85                  90                  95      


Asp Thr Val Leu Gly Leu Leu Asp Ser His Leu Ile Lys Glu Ala Gly 
            100                 105                 110         


Asp Ala Glu Ser Arg Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr 
        115                 120                 125             


Arg Tyr Leu Ala Glu Val Ala Thr Gly Asp Asp Lys Lys Arg Ile Ile 
    130                 135                 140                 


Asp Ser Ala Arg Ser Ala Tyr Gln Glu Ala Met Asp Ile Ser Lys Lys 
145                 150                 155                 160 


Glu Met Pro Pro Thr Asn Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
                165                 170                 175     


Ser Val Phe His Tyr Glu Ile Ala Asn Ser Pro Glu Glu Ala Ile Ser 
            180                 185                 190         


Leu Ala Lys Thr Thr Phe Asp Glu Ala Met Ala Asp Leu His Thr Leu 
        195                 200                 205             


Ser Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
    210                 215                 220                 


Asp Asn Leu Thr Leu Trp Thr Ala Asp Asn Ala Gly Glu Glu Gly Gly 
225                 230                 235                 240 


Glu Ala Pro Gln Glu Pro Gln Ser 
                245             


<210>  65
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val 
225             


<210>  66
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Gln Gly Pro Pro Leu Leu Thr Ala Ala His Leu Leu Cys Val Cys 
1               5                   10                  15      


Thr Ala Ala Leu Ala Val Ala Pro Gly Pro Arg Phe Leu Val Thr Ala 
            20                  25                  30          


Pro Gly Ile Ile Arg Pro Gly Gly Asn Val Thr Ile Gly Val Glu Leu 
        35                  40                  45              


Leu Glu His Cys Pro Ser Gln Val Thr Val Lys Ala Glu Leu Leu Lys 
    50                  55                  60                  


Thr Ala Ser Asn Leu Thr Val Ser Val Leu Glu Ala Glu Gly Val Phe 
65                  70                  75                  80  


Glu Lys Gly Ser Phe Lys Thr Leu Thr Leu Pro Ser Leu Pro Leu Asn 
                85                  90                  95      


Ser Ala Asp Glu Ile Tyr Glu Leu Arg Val Thr Gly Arg Thr Gln Asp 
            100                 105                 110         


Glu Ile Leu Phe Ser Asn Ser Thr Arg Leu Ser Phe Glu Thr Lys Arg 
        115                 120                 125             


Ile Ser Val Phe Ile Gln Thr Asp Lys Ala Leu Tyr Lys Pro Lys Gln 
    130                 135                 140                 


Glu Val Lys Phe Arg Ile Val Thr Leu Phe Ser Asp Phe Lys Pro Tyr 
145                 150                 155                 160 


Lys Thr Ser Leu Asn Ile Leu Ile Lys Asp Pro Lys Ser Asn Leu Ile 
                165                 170                 175     


Gln Gln Trp Leu Ser Gln Gln Ser Asp Leu Gly Val Ile Ser Lys Thr 
            180                 185                 190         


Phe Gln Leu Ser Ser His Pro Ile Leu Gly Asp Trp Ser Ile Gln Val 
        195                 200                 205             


Gln Val Asn Asp Gln Thr Tyr Tyr Gln Ser Phe Gln Val Ser Glu Tyr 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Thr Leu Gln Thr Pro Leu Tyr Cys Ser 
225                 230                 235                 240 


Met Asn Ser Lys His Leu Asn Gly Thr Ile Thr Ala Lys Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Lys Gly Asp Val Thr Leu Thr Phe Leu Pro Leu Ser 
            260                 265                 270         


Phe Trp Gly Lys Lys Lys Asn Ile Thr Lys Thr Phe Lys Ile Asn Gly 
        275                 280                 285             


Ser Ala Asn Phe Ser Phe Asn Asp Glu Glu Met Lys Asn Val Met Asp 
    290                 295                 300                 


Ser Ser Asn Gly Leu Ser Glu Tyr Leu Asp Leu Ser Ser Pro Gly Pro 
305                 310                 315                 320 


Val Glu Ile Leu Thr Thr Val Thr Glu Ser Val Thr Gly Ile Ser Arg 
                325                 330                 335     


Asn Val Ser Thr Asn Val Phe Phe Lys Gln His Asp Tyr Ile Ile Glu 
            340                 345                 350         


Phe Phe Asp Tyr Thr Thr Val Leu Lys Pro Ser Leu Asn Phe Thr Ala 
        355                 360                 365             


Thr Val Lys Val Thr Arg Ala Asp Gly Asn Gln Leu Thr Leu Glu Glu 
    370                 375                 380                 


Arg Arg Asn Asn Val Val Ile Thr Val Thr Gln Arg Asn Tyr Thr Glu 
385                 390                 395                 400 


Tyr Trp Ser Gly Ser Asn Ser Gly Asn Gln Lys Met Glu Ala Val Gln 
                405                 410                 415     


Lys Ile Asn Tyr Thr Val Pro Gln Ser Gly Thr Phe Lys Ile Glu Phe 
            420                 425                 430         


Pro Ile Leu Glu Asp Ser Ser Glu Leu Gln Leu Lys Ala Tyr Phe Leu 
        435                 440                 445             


Gly Ser Lys Ser Ser Met Ala Val His Ser Leu Phe Lys Ser Pro Ser 
    450                 455                 460                 


Lys Thr Tyr Ile Gln Leu Lys Thr Arg Asp Glu Asn Ile Lys Val Gly 
465                 470                 475                 480 


Ser Pro Phe Glu Leu Val Val Ser Gly Asn Lys Arg Leu Lys Glu Leu 
                485                 490                 495     


Ser Tyr Met Val Val Ser Arg Gly Gln Leu Val Ala Val Gly Lys Gln 
            500                 505                 510         


Asn Ser Thr Met Phe Ser Leu Thr Pro Glu Asn Ser Trp Thr Pro Lys 
        515                 520                 525             


Ala Cys Val Ile Val Tyr Tyr Ile Glu Asp Asp Gly Glu Ile Ile Ser 
    530                 535                 540                 


Asp Val Leu Lys Ile Pro Val Gln Leu Val Phe Lys Asn Lys Ile Lys 
545                 550                 555                 560 


Leu Tyr Trp Ser Lys Val Lys Ala Glu Pro Ser Glu Lys Val Ser Leu 
                565                 570                 575     


Arg Ile Ser Val Thr Gln Pro Asp Ser Ile Val Gly Ile Val Ala Val 
            580                 585                 590         


Asp Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile Thr Met Glu 
        595                 600                 605             


Asn Val Val His Glu Leu Glu Leu Tyr Asn Thr Gly Tyr Tyr Leu Gly 
    610                 615                 620                 


Met Phe Met Asn Ser Phe Ala Val Phe Gln Glu Cys Gly Leu Trp Val 
625                 630                 635                 640 


Leu Thr Asp Ala Asn Leu Thr Lys Asp Tyr Ile Asp Gly Val Tyr Asp 
                645                 650                 655     


Asn Ala Glu Tyr Ala Glu Arg Phe Met Glu Glu Asn Glu Gly His Ile 
            660                 665                 670         


Val Asp Ile His Asp Phe Ser Leu Gly Ser Ser Pro His Val Arg Lys 
        675                 680                 685             


His Phe Pro Glu Thr Trp Ile Trp Leu Asp Thr Asn Met Gly Tyr Arg 
    690                 695                 700                 


Ile Tyr Gln Glu Phe Glu Val Thr Val Pro Asp Ser Ile Thr Ser Trp 
705                 710                 715                 720 


Val Ala Thr Gly Phe Val Ile Ser Glu Asp Leu Gly Leu Gly Leu Thr 
                725                 730                 735     


Thr Thr Pro Val Glu Leu Gln Ala Phe Gln Pro Phe Phe Ile Phe Leu 
            740                 745                 750         


Asn Leu Pro Tyr Ser Val Ile Arg Gly Glu Glu Phe Ala Leu Glu Ile 
        755                 760                 765             


Thr Ile Phe Asn Tyr Leu Lys Asp Ala Thr Glu Val Lys Val Ile Ile 
    770                 775                 780                 


Glu Lys Ser Asp Lys Phe Asp Ile Leu Met Thr Ser Asn Glu Ile Asn 
785                 790                 795                 800 


Ala Thr Gly His Gln Gln Thr Leu Leu Val Pro Ser Glu Asp Gly Ala 
                805                 810                 815     


Thr Val Leu Phe Pro Ile Arg Pro Thr His Leu Gly Glu Ile Pro Ile 
            820                 825                 830         


Thr Val Thr Ala Leu Ser Pro Thr Ala Ser Asp Ala Val Thr Gln Met 
        835                 840                 845             


Ile Leu Val Lys Ala Glu Gly Ile Glu Lys Ser Tyr Ser Gln Ser Ile 
    850                 855                 860                 


Leu Leu Asp Leu Thr Asp Asn Arg Leu Gln Ser Thr Leu Lys Thr Leu 
865                 870                 875                 880 


Ser Phe Ser Phe Pro Pro Asn Thr Val Thr Gly Ser Glu Arg Val Gln 
                885                 890                 895     


Ile Thr Ala Ile Gly Asp Val Leu Gly Pro Ser Ile Asn Gly Leu Ala 
            900                 905                 910         


Ser Leu Ile Arg Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Ile Asn 
        915                 920                 925             


Phe Ala Pro Asn Ile Tyr Ile Leu Asp Tyr Leu Thr Lys Lys Lys Gln 
    930                 935                 940                 


Leu Thr Asp Asn Leu Lys Glu Lys Ala Leu Ser Phe Met Arg Gln Gly 
945                 950                 955                 960 


Tyr Gln Arg Glu Leu Leu Tyr Gln Arg Glu Asp Gly Ser Phe Ser Ala 
                965                 970                 975     


Phe Gly Asn Tyr Asp Pro Ser Gly Ser Thr Trp Leu Ser Ala Phe Val 
            980                 985                 990         


Leu Arg Cys Phe Leu Glu Ala Asp  Pro Tyr Ile Asp Ile  Asp Gln Asn 
        995                 1000                 1005             


Val Leu  His Arg Thr Tyr Thr  Trp Leu Lys Gly His  Gln Lys Ser 
    1010                 1015                 1020             


Asn Gly  Glu Phe Trp Asp Pro  Gly Arg Val Ile His  Ser Glu Leu 
    1025                 1030                 1035             


Gln Gly  Gly Asn Lys Ser Pro  Val Thr Leu Thr Ala  Tyr Ile Val 
    1040                 1045                 1050             


Thr Ser  Leu Leu Gly Tyr Arg  Lys Tyr Gln Pro Asn  Ile Asp Val 
    1055                 1060                 1065             


Gln Glu  Ser Ile His Phe Leu  Glu Ser Glu Phe Ser  Arg Gly Ile 
    1070                 1075                 1080             


Ser Asp  Asn Tyr Thr Leu Ala  Leu Ile Thr Tyr Ala  Leu Ser Ser 
    1085                 1090                 1095             


Val Gly  Ser Pro Lys Ala Lys  Glu Ala Leu Asn Met  Leu Thr Trp 
    1100                 1105                 1110             


Arg Ala  Glu Gln Glu Gly Gly  Met Gln Phe Trp Val  Ser Ser Glu 
    1115                 1120                 1125             


Ser Lys  Leu Ser Asp Ser Trp  Gln Pro Arg Ser Leu  Asp Ile Glu 
    1130                 1135                 1140             


Val Ala  Ala Tyr Ala Leu Leu  Ser His Phe Leu Gln  Phe Gln Thr 
    1145                 1150                 1155             


Ser Glu  Gly Ile Pro Ile Met  Arg Trp Leu Ser Arg  Gln Arg Asn 
    1160                 1165                 1170             


Ser Leu  Gly Gly Phe Ala Ser  Thr Gln Asp Thr Thr  Val Ala Leu 
    1175                 1180                 1185             


Lys Ala  Leu Ser Glu Phe Ala  Ala Leu Met Asn Thr  Glu Arg Thr 
    1190                 1195                 1200             


Asn Ile  Gln Val Thr Val Thr  Gly Pro Ser Ser Pro  Ser Pro Val 
    1205                 1210                 1215             


Lys Phe  Leu Ile Asp Thr His  Asn Arg Leu Leu Leu  Gln Thr Ala 
    1220                 1225                 1230             


Glu Leu  Ala Val Val Gln Pro  Thr Ala Val Asn Ile  Ser Ala Asn 
    1235                 1240                 1245             


Gly Phe  Gly Phe Ala Ile Cys  Gln Leu Asn Val Val  Tyr Asn Val 
    1250                 1255                 1260             


Lys Ala  Ser Gly Ser Ser Arg  Arg Arg Arg Ser Ile  Gln Asn Gln 
    1265                 1270                 1275             


Glu Ala  Phe Asp Leu Asp Val  Ala Val Lys Glu Asn  Lys Asp Asp 
    1280                 1285                 1290             


Leu Asn  His Val Asp Leu Asn  Val Cys Thr Ser Phe  Ser Gly Pro 
    1295                 1300                 1305             


Gly Arg  Ser Gly Met Ala Leu  Met Glu Val Asn Leu  Leu Ser Gly 
    1310                 1315                 1320             


Phe Met  Val Pro Ser Glu Ala  Ile Ser Leu Ser Glu  Thr Val Lys 
    1325                 1330                 1335             


Lys Val  Glu Tyr Asp His Gly  Lys Leu Asn Leu Tyr  Leu Asp Ser 
    1340                 1345                 1350             


Val Asn  Glu Thr Gln Phe Cys  Val Asn Ile Pro Ala  Val Arg Asn 
    1355                 1360                 1365             


Phe Lys  Val Ser Asn Thr Gln  Asp Ala Ser Val Ser  Ile Val Asp 
    1370                 1375                 1380             


Tyr Tyr  Glu Pro Arg Arg Gln  Ala Val Arg Ser Tyr  Asn Ser Glu 
    1385                 1390                 1395             


Val Lys  Leu Ser Ser Cys Asp  Leu Cys Ser Asp Val  Gln Gly Cys 
    1400                 1405                 1410             


Arg Pro  Cys Glu Asp Gly Ala  Ser Gly Ser His His  His Ser Ser 
    1415                 1420                 1425             


Val Ile  Phe Ile Phe Cys Phe  Lys Leu Leu Tyr Phe  Met Glu Leu 
    1430                 1435                 1440             


Trp Leu  
    1445 


<210>  67
<211>  1428
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Gln Gly Pro Pro Leu Leu Thr Ala Ala His Leu Leu Cys Val Cys 
1               5                   10                  15      


Thr Ala Ala Leu Ala Val Ala Pro Gly Pro Arg Phe Leu Val Thr Ala 
            20                  25                  30          


Pro Gly Ile Ile Arg Pro Gly Gly Asn Val Thr Ile Gly Val Glu Leu 
        35                  40                  45              


Leu Glu His Cys Pro Ser Gln Val Thr Val Lys Ala Glu Leu Leu Lys 
    50                  55                  60                  


Thr Ala Ser Asn Leu Thr Val Ser Val Leu Glu Ala Glu Gly Val Phe 
65                  70                  75                  80  


Glu Lys Gly Ser Phe Lys Thr Leu Thr Leu Pro Ser Leu Pro Leu Asn 
                85                  90                  95      


Ser Ala Asp Glu Ile Tyr Glu Leu Arg Val Thr Gly Arg Thr Gln Asp 
            100                 105                 110         


Glu Ile Leu Phe Ser Asn Ser Thr Arg Leu Ser Phe Glu Thr Lys Arg 
        115                 120                 125             


Ile Ser Val Phe Ile Gln Thr Asp Lys Ala Leu Tyr Lys Pro Lys Gln 
    130                 135                 140                 


Glu Val Lys Phe Arg Ile Val Thr Leu Phe Ser Asp Phe Lys Pro Tyr 
145                 150                 155                 160 


Lys Thr Ser Leu Asn Ile Leu Ile Lys Asp Pro Lys Ser Asn Leu Ile 
                165                 170                 175     


Gln Gln Trp Leu Ser Gln Gln Ser Asp Leu Gly Val Ile Ser Lys Thr 
            180                 185                 190         


Phe Gln Leu Ser Ser His Pro Ile Leu Gly Asp Trp Ser Ile Gln Val 
        195                 200                 205             


Gln Val Asn Asp Gln Thr Tyr Tyr Gln Ser Phe Gln Val Ser Glu Tyr 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Thr Leu Gln Thr Pro Leu Tyr Cys Ser 
225                 230                 235                 240 


Met Asn Ser Lys His Leu Asn Gly Thr Ile Thr Ala Lys Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Lys Gly Asp Val Thr Leu Thr Phe Leu Pro Leu Ser 
            260                 265                 270         


Phe Trp Gly Lys Lys Lys Asn Ile Thr Lys Thr Phe Lys Ile Asn Gly 
        275                 280                 285             


Ser Ala Asn Phe Ser Phe Asn Asp Glu Glu Met Lys Asn Val Met Asp 
    290                 295                 300                 


Ser Ser Asn Gly Leu Ser Glu Tyr Leu Asp Leu Ser Ser Pro Gly Pro 
305                 310                 315                 320 


Val Glu Ile Leu Thr Thr Val Thr Glu Ser Val Thr Gly Ile Ser Arg 
                325                 330                 335     


Asn Val Ser Thr Asn Val Phe Phe Lys Gln His Asp Tyr Ile Ile Glu 
            340                 345                 350         


Phe Phe Asp Tyr Thr Thr Val Leu Lys Pro Ser Leu Asn Phe Thr Ala 
        355                 360                 365             


Thr Val Lys Val Thr Arg Ala Asp Gly Asn Gln Leu Thr Leu Glu Glu 
    370                 375                 380                 


Arg Arg Asn Asn Val Val Ile Thr Val Thr Gln Arg Asn Tyr Thr Glu 
385                 390                 395                 400 


Tyr Trp Ser Gly Ser Asn Ser Gly Asn Gln Lys Met Glu Ala Val Gln 
                405                 410                 415     


Lys Ile Asn Tyr Thr Val Pro Gln Ser Gly Thr Phe Lys Ile Glu Phe 
            420                 425                 430         


Pro Ile Leu Glu Asp Ser Ser Glu Leu Gln Leu Lys Ala Tyr Phe Leu 
        435                 440                 445             


Gly Ser Lys Ser Ser Met Ala Val His Ser Leu Phe Lys Ser Pro Ser 
    450                 455                 460                 


Lys Thr Tyr Ile Gln Leu Lys Thr Arg Asp Glu Asn Ile Lys Val Gly 
465                 470                 475                 480 


Ser Pro Phe Glu Leu Val Val Ser Gly Asn Lys Arg Leu Lys Glu Leu 
                485                 490                 495     


Ser Tyr Met Val Val Ser Arg Gly Gln Leu Val Ala Val Gly Lys Gln 
            500                 505                 510         


Asn Ser Thr Met Phe Ser Leu Thr Pro Glu Asn Ser Trp Thr Pro Lys 
        515                 520                 525             


Ala Cys Val Ile Val Tyr Tyr Ile Glu Asp Asp Gly Glu Ile Ile Ser 
    530                 535                 540                 


Asp Val Leu Lys Ile Pro Val Gln Leu Val Phe Lys Asn Lys Ile Lys 
545                 550                 555                 560 


Leu Tyr Trp Ser Lys Val Lys Ala Glu Pro Ser Glu Lys Val Ser Leu 
                565                 570                 575     


Arg Ile Ser Val Thr Gln Pro Asp Ser Ile Val Gly Ile Val Ala Val 
            580                 585                 590         


Asp Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile Thr Met Glu 
        595                 600                 605             


Asn Val Val His Glu Leu Glu Leu Tyr Asn Thr Gly Tyr Tyr Leu Gly 
    610                 615                 620                 


Met Phe Met Asn Ser Phe Ala Val Phe Gln Glu Cys Gly Leu Trp Val 
625                 630                 635                 640 


Leu Thr Asp Ala Asn Leu Thr Lys Asp Tyr Ile Asp Gly Val Tyr Asp 
                645                 650                 655     


Asn Ala Glu Tyr Ala Glu Arg Phe Met Glu Glu Asn Glu Gly His Ile 
            660                 665                 670         


Val Asp Ile His Asp Phe Ser Leu Gly Ser Ser Pro His Val Arg Lys 
        675                 680                 685             


His Phe Pro Glu Thr Trp Ile Trp Leu Asp Thr Asn Met Gly Tyr Arg 
    690                 695                 700                 


Ile Tyr Gln Glu Phe Glu Val Thr Val Pro Asp Ser Ile Thr Ser Trp 
705                 710                 715                 720 


Val Ala Thr Gly Phe Val Ile Ser Glu Asp Leu Gly Leu Gly Leu Thr 
                725                 730                 735     


Thr Thr Pro Val Glu Leu Gln Ala Phe Gln Pro Phe Phe Ile Phe Leu 
            740                 745                 750         


Asn Leu Pro Tyr Ser Val Ile Arg Gly Glu Glu Phe Ala Leu Glu Ile 
        755                 760                 765             


Thr Ile Phe Asn Tyr Leu Lys Asp Ala Thr Glu Val Lys Val Ile Ile 
    770                 775                 780                 


Glu Lys Ser Asp Lys Phe Asp Ile Leu Met Thr Ser Asn Glu Ile Asn 
785                 790                 795                 800 


Ala Thr Gly His Gln Gln Thr Leu Leu Val Pro Ser Glu Asp Gly Ala 
                805                 810                 815     


Thr Val Leu Phe Pro Ile Arg Pro Thr His Leu Gly Glu Ile Pro Ile 
            820                 825                 830         


Thr Val Thr Ala Leu Ser Pro Thr Ala Ser Asp Ala Val Thr Gln Met 
        835                 840                 845             


Ile Leu Val Lys Ala Glu Gly Ile Glu Lys Ser Tyr Ser Gln Ser Ile 
    850                 855                 860                 


Leu Leu Asp Leu Thr Asp Asn Arg Leu Gln Ser Thr Leu Lys Thr Leu 
865                 870                 875                 880 


Ser Phe Ser Phe Pro Pro Asn Thr Val Thr Gly Ser Glu Arg Val Gln 
                885                 890                 895     


Ile Thr Ala Ile Gly Asp Val Leu Gly Pro Ser Ile Asn Gly Leu Ala 
            900                 905                 910         


Ser Leu Ile Arg Met Pro Tyr Gly Cys Gly Glu Gln Asn Met Ile Asn 
        915                 920                 925             


Phe Ala Pro Asn Ile Tyr Ile Leu Asp Tyr Leu Thr Lys Lys Lys Gln 
    930                 935                 940                 


Leu Thr Asp Asn Leu Lys Glu Lys Ala Leu Ser Phe Met Arg Gln Gly 
945                 950                 955                 960 


Tyr Gln Arg Glu Leu Leu Tyr Gln Arg Glu Asp Gly Ser Phe Ser Ala 
                965                 970                 975     


Phe Gly Asn Tyr Asp Pro Ser Gly Ser Thr Trp Leu Ser Ala Phe Val 
            980                 985                 990         


Leu Arg Cys Phe Leu Glu Ala Asp  Pro Tyr Ile Asp Ile  Asp Gln Asn 
        995                 1000                 1005             


Val Leu  His Arg Thr Tyr Thr  Trp Leu Lys Gly His  Gln Lys Ser 
    1010                 1015                 1020             


Asn Gly  Glu Phe Trp Asp Pro  Gly Arg Val Ile His  Ser Glu Leu 
    1025                 1030                 1035             


Gln Gly  Gly Asn Lys Ser Pro  Val Thr Leu Thr Ala  Tyr Ile Val 
    1040                 1045                 1050             


Thr Ser  Leu Leu Gly Tyr Arg  Lys Tyr Gln Pro Asn  Ile Asp Val 
    1055                 1060                 1065             


Gln Glu  Ser Ile His Phe Leu  Glu Ser Glu Phe Ser  Arg Gly Ile 
    1070                 1075                 1080             


Ser Asp  Asn Tyr Thr Leu Ala  Leu Ile Thr Tyr Ala  Leu Ser Ser 
    1085                 1090                 1095             


Val Gly  Ser Pro Lys Ala Lys  Glu Ala Leu Asn Met  Leu Thr Trp 
    1100                 1105                 1110             


Arg Ala  Glu Gln Glu Gly Gly  Met Gln Phe Trp Val  Ser Ser Glu 
    1115                 1120                 1125             


Ser Lys  Leu Ser Asp Ser Trp  Gln Pro Arg Ser Leu  Asp Ile Glu 
    1130                 1135                 1140             


Val Ala  Ala Tyr Ala Leu Leu  Ser His Phe Leu Gln  Phe Gln Thr 
    1145                 1150                 1155             


Ser Glu  Gly Ile Pro Ile Met  Arg Trp Leu Ser Arg  Gln Arg Asn 
    1160                 1165                 1170             


Ser Leu  Gly Gly Phe Ala Ser  Thr Gln Asp Thr Thr  Val Ala Leu 
    1175                 1180                 1185             


Lys Ala  Leu Ser Glu Phe Ala  Ala Leu Met Asn Thr  Glu Arg Thr 
    1190                 1195                 1200             


Asn Ile  Gln Val Thr Val Thr  Gly Pro Ser Ser Pro  Ser Pro Leu 
    1205                 1210                 1215             


Ala Val  Val Gln Pro Thr Ala  Val Asn Ile Ser Ala  Asn Gly Phe 
    1220                 1225                 1230             


Gly Phe  Ala Ile Cys Gln Leu  Asn Val Val Tyr Asn  Val Lys Ala 
    1235                 1240                 1245             


Ser Gly  Ser Ser Arg Arg Arg  Arg Ser Ile Gln Asn  Gln Glu Ala 
    1250                 1255                 1260             


Phe Asp  Leu Asp Val Ala Val  Lys Glu Asn Lys Asp  Asp Leu Asn 
    1265                 1270                 1275             


His Val  Asp Leu Asn Val Cys  Thr Ser Phe Ser Gly  Pro Gly Arg 
    1280                 1285                 1290             


Ser Gly  Met Ala Leu Met Glu  Val Asn Leu Leu Ser  Gly Phe Met 
    1295                 1300                 1305             


Val Pro  Ser Glu Ala Ile Ser  Leu Ser Glu Thr Val  Lys Lys Val 
    1310                 1315                 1320             


Glu Tyr  Asp His Gly Lys Leu  Asn Leu Tyr Leu Asp  Ser Val Asn 
    1325                 1330                 1335             


Glu Thr  Gln Phe Cys Val Asn  Ile Pro Ala Val Arg  Asn Phe Lys 
    1340                 1345                 1350             


Val Ser  Asn Thr Gln Asp Ala  Ser Val Ser Ile Val  Asp Tyr Tyr 
    1355                 1360                 1365             


Glu Pro  Arg Arg Gln Ala Val  Arg Ser Tyr Asn Ser  Glu Val Lys 
    1370                 1375                 1380             


Leu Ser  Ser Cys Asp Leu Cys  Ser Asp Val Gln Gly  Cys Arg Pro 
    1385                 1390                 1395             


Cys Glu  Asp Gly Ala Ser Gly  Ser His His His Ser  Ser Val Ile 
    1400                 1405                 1410             


Phe Ile  Phe Cys Phe Lys Leu  Leu Tyr Phe Met Glu  Leu Trp Leu 
    1415                 1420                 1425             


<210>  68
<211>  1368
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gln Gly Pro Pro Leu Leu Thr Ala Ala His Leu Leu Cys Val Cys 
1               5                   10                  15      


Thr Ala Ala Leu Ala Val Ala Pro Gly Pro Arg Phe Leu Val Thr Ala 
            20                  25                  30          


Pro Gly Ile Ile Arg Pro Gly Gly Asn Val Thr Ile Gly Val Glu Leu 
        35                  40                  45              


Leu Glu His Cys Pro Ser Gln Val Thr Val Lys Ala Glu Leu Leu Lys 
    50                  55                  60                  


Thr Ala Ser Asn Leu Thr Val Ser Val Leu Glu Ala Glu Gly Val Phe 
65                  70                  75                  80  


Glu Lys Gly Ser Phe Lys Thr Leu Thr Leu Pro Ser Asp Pro Lys Ser 
                85                  90                  95      


Asn Leu Ile Gln Gln Trp Leu Ser Gln Gln Ser Asp Leu Gly Val Ile 
            100                 105                 110         


Ser Lys Thr Phe Gln Leu Ser Ser His Pro Ile Leu Gly Asp Trp Ser 
        115                 120                 125             


Ile Gln Val Gln Val Asn Asp Gln Thr Tyr Tyr Gln Ser Phe Gln Val 
    130                 135                 140                 


Ser Glu Tyr Val Leu Pro Lys Phe Glu Val Thr Leu Gln Thr Pro Leu 
145                 150                 155                 160 


Tyr Cys Ser Met Asn Ser Lys His Leu Asn Gly Thr Ile Thr Ala Lys 
                165                 170                 175     


Tyr Thr Tyr Gly Lys Pro Val Lys Gly Asp Val Thr Leu Thr Phe Leu 
            180                 185                 190         


Pro Leu Ser Phe Trp Gly Lys Lys Lys Asn Ile Thr Lys Thr Phe Lys 
        195                 200                 205             


Ile Asn Gly Ser Ala Asn Phe Ser Phe Asn Asp Glu Glu Met Lys Asn 
    210                 215                 220                 


Val Met Asp Ser Ser Asn Gly Leu Ser Glu Tyr Leu Asp Leu Ser Ser 
225                 230                 235                 240 


Pro Gly Pro Val Glu Ile Leu Thr Thr Val Thr Glu Ser Val Thr Gly 
                245                 250                 255     


Ile Ser Arg Asn Val Ser Thr Asn Val Phe Phe Lys Gln His Asp Tyr 
            260                 265                 270         


Ile Ile Glu Phe Phe Asp Tyr Thr Thr Val Leu Lys Pro Ser Leu Asn 
        275                 280                 285             


Phe Thr Ala Thr Val Lys Val Thr Arg Ala Asp Gly Asn Gln Leu Thr 
    290                 295                 300                 


Leu Glu Glu Arg Arg Asn Asn Val Val Ile Thr Val Thr Gln Arg Asn 
305                 310                 315                 320 


Tyr Thr Glu Tyr Trp Ser Gly Ser Asn Ser Gly Asn Gln Lys Met Glu 
                325                 330                 335     


Ala Val Gln Lys Ile Asn Tyr Thr Val Pro Gln Ser Gly Thr Phe Lys 
            340                 345                 350         


Ile Glu Phe Pro Ile Leu Glu Asp Ser Ser Glu Leu Gln Leu Lys Ala 
        355                 360                 365             


Tyr Phe Leu Gly Ser Lys Ser Ser Met Ala Val His Ser Leu Phe Lys 
    370                 375                 380                 


Ser Pro Ser Lys Thr Tyr Ile Gln Leu Lys Thr Arg Asp Glu Asn Ile 
385                 390                 395                 400 


Lys Val Gly Ser Pro Phe Glu Leu Val Val Ser Gly Asn Lys Arg Leu 
                405                 410                 415     


Lys Glu Leu Ser Tyr Met Val Val Ser Arg Gly Gln Leu Val Ala Val 
            420                 425                 430         


Gly Lys Gln Asn Ser Thr Met Phe Ser Leu Thr Pro Glu Asn Ser Trp 
        435                 440                 445             


Thr Pro Lys Ala Cys Val Ile Val Tyr Tyr Ile Glu Asp Asp Gly Glu 
    450                 455                 460                 


Ile Ile Ser Asp Val Leu Lys Ile Pro Val Gln Leu Val Phe Lys Asn 
465                 470                 475                 480 


Lys Ile Lys Leu Tyr Trp Ser Lys Val Lys Ala Glu Pro Ser Glu Lys 
                485                 490                 495     


Val Ser Leu Arg Ile Ser Val Thr Gln Pro Asp Ser Ile Val Gly Ile 
            500                 505                 510         


Val Ala Val Asp Lys Ser Val Asn Leu Met Asn Ala Ser Asn Asp Ile 
        515                 520                 525             


Thr Met Glu Asn Val Val His Glu Leu Glu Leu Tyr Asn Thr Gly Tyr 
    530                 535                 540                 


Tyr Leu Gly Met Phe Met Asn Ser Phe Ala Val Phe Gln Glu Cys Gly 
545                 550                 555                 560 


Leu Trp Val Leu Thr Asp Ala Asn Leu Thr Lys Asp Tyr Ile Asp Gly 
                565                 570                 575     


Val Tyr Asp Asn Ala Glu Tyr Ala Glu Arg Phe Met Glu Glu Asn Glu 
            580                 585                 590         


Gly His Ile Val Asp Ile His Asp Phe Ser Leu Gly Ser Ser Pro His 
        595                 600                 605             


Val Arg Lys His Phe Pro Glu Thr Trp Ile Trp Leu Asp Thr Asn Met 
    610                 615                 620                 


Gly Tyr Arg Ile Tyr Gln Glu Phe Glu Val Thr Val Pro Asp Ser Ile 
625                 630                 635                 640 


Thr Ser Trp Val Ala Thr Gly Phe Val Ile Ser Glu Asp Leu Gly Leu 
                645                 650                 655     


Gly Leu Thr Thr Thr Pro Val Glu Leu Gln Ala Phe Gln Pro Phe Phe 
            660                 665                 670         


Ile Phe Leu Asn Leu Pro Tyr Ser Val Ile Arg Gly Glu Glu Phe Ala 
        675                 680                 685             


Leu Glu Ile Thr Ile Phe Asn Tyr Leu Lys Asp Ala Thr Glu Val Lys 
    690                 695                 700                 


Val Ile Ile Glu Lys Ser Asp Lys Phe Asp Ile Leu Met Thr Ser Asn 
705                 710                 715                 720 


Glu Ile Asn Ala Thr Gly His Gln Gln Thr Leu Leu Val Pro Ser Glu 
                725                 730                 735     


Asp Gly Ala Thr Val Leu Phe Pro Ile Arg Pro Thr His Leu Gly Glu 
            740                 745                 750         


Ile Pro Ile Thr Val Thr Ala Leu Ser Pro Thr Ala Ser Asp Ala Val 
        755                 760                 765             


Thr Gln Met Ile Leu Val Lys Ala Glu Gly Ile Glu Lys Ser Tyr Ser 
    770                 775                 780                 


Gln Ser Ile Leu Leu Asp Leu Thr Asp Asn Arg Leu Gln Ser Thr Leu 
785                 790                 795                 800 


Lys Thr Leu Ser Phe Ser Phe Pro Pro Asn Thr Val Thr Gly Ser Glu 
                805                 810                 815     


Arg Val Gln Ile Thr Ala Ile Gly Asp Val Leu Gly Pro Ser Ile Asn 
            820                 825                 830         


Gly Leu Ala Ser Leu Ile Arg Met Pro Tyr Gly Cys Gly Glu Gln Asn 
        835                 840                 845             


Met Ile Asn Phe Ala Pro Asn Ile Tyr Ile Leu Asp Tyr Leu Thr Lys 
    850                 855                 860                 


Lys Lys Gln Leu Thr Asp Asn Leu Lys Glu Lys Ala Leu Ser Phe Met 
865                 870                 875                 880 


Arg Gln Gly Tyr Gln Arg Glu Leu Leu Tyr Gln Arg Glu Asp Gly Ser 
                885                 890                 895     


Phe Ser Ala Phe Gly Asn Tyr Asp Pro Ser Gly Ser Thr Trp Leu Ser 
            900                 905                 910         


Ala Phe Val Leu Arg Cys Phe Leu Glu Ala Asp Pro Tyr Ile Asp Ile 
        915                 920                 925             


Asp Gln Asn Val Leu His Arg Thr Tyr Thr Trp Leu Lys Gly His Gln 
    930                 935                 940                 


Lys Ser Asn Gly Glu Phe Trp Asp Pro Gly Arg Val Ile His Ser Glu 
945                 950                 955                 960 


Leu Gln Gly Gly Asn Lys Ser Pro Val Thr Leu Thr Ala Tyr Ile Val 
                965                 970                 975     


Thr Ser Leu Leu Gly Tyr Arg Lys Tyr Gln Pro Asn Ile Asp Val Gln 
            980                 985                 990         


Glu Ser Ile His Phe Leu Glu Ser  Glu Phe Ser Arg Gly  Ile Ser Asp 
        995                 1000                 1005             


Asn Tyr  Thr Leu Ala Leu Ile  Thr Tyr Ala Leu Ser  Ser Val Gly 
    1010                 1015                 1020             


Ser Pro  Lys Ala Lys Glu Ala  Leu Asn Met Leu Thr  Trp Arg Ala 
    1025                 1030                 1035             


Glu Gln  Glu Gly Gly Met Gln  Phe Trp Val Ser Ser  Glu Ser Lys 
    1040                 1045                 1050             


Leu Ser  Asp Ser Trp Gln Pro  Arg Ser Leu Asp Ile  Glu Val Ala 
    1055                 1060                 1065             


Ala Tyr  Ala Leu Leu Ser His  Phe Leu Gln Phe Gln  Thr Ser Glu 
    1070                 1075                 1080             


Gly Ile  Pro Ile Met Arg Trp  Leu Ser Arg Gln Arg  Asn Ser Leu 
    1085                 1090                 1095             


Gly Gly  Phe Ala Ser Thr Gln  Asp Thr Thr Val Ala  Leu Lys Ala 
    1100                 1105                 1110             


Leu Ser  Glu Phe Ala Ala Leu  Met Asn Thr Glu Arg  Thr Asn Ile 
    1115                 1120                 1125             


Gln Val  Thr Val Thr Gly Pro  Ser Ser Pro Ser Pro  Val Lys Phe 
    1130                 1135                 1140             


Leu Ile  Asp Thr His Asn Arg  Leu Leu Leu Gln Thr  Ala Glu Leu 
    1145                 1150                 1155             


Ala Val  Val Gln Pro Thr Ala  Val Asn Ile Ser Ala  Asn Gly Phe 
    1160                 1165                 1170             


Gly Phe  Ala Ile Cys Gln Leu  Asn Val Val Tyr Asn  Val Lys Ala 
    1175                 1180                 1185             


Ser Gly  Ser Ser Arg Arg Arg  Arg Ser Ile Gln Asn  Gln Glu Ala 
    1190                 1195                 1200             


Phe Asp  Leu Asp Val Ala Val  Lys Glu Asn Lys Asp  Asp Leu Asn 
    1205                 1210                 1215             


His Val  Asp Leu Asn Val Cys  Thr Ser Phe Ser Gly  Pro Gly Arg 
    1220                 1225                 1230             


Ser Gly  Met Ala Leu Met Glu  Val Asn Leu Leu Ser  Gly Phe Met 
    1235                 1240                 1245             


Val Pro  Ser Glu Ala Ile Ser  Leu Ser Glu Thr Val  Lys Lys Val 
    1250                 1255                 1260             


Glu Tyr  Asp His Gly Lys Leu  Asn Leu Tyr Leu Asp  Ser Val Asn 
    1265                 1270                 1275             


Glu Thr  Gln Phe Cys Val Asn  Ile Pro Ala Val Arg  Asn Phe Lys 
    1280                 1285                 1290             


Val Ser  Asn Thr Gln Asp Ala  Ser Val Ser Ile Val  Asp Tyr Tyr 
    1295                 1300                 1305             


Glu Pro  Arg Arg Gln Ala Val  Arg Ser Tyr Asn Ser  Glu Val Lys 
    1310                 1315                 1320             


Leu Ser  Ser Cys Asp Leu Cys  Ser Asp Val Gln Gly  Cys Arg Pro 
    1325                 1330                 1335             


Cys Glu  Asp Gly Ala Ser Gly  Ser His His His Ser  Ser Val Ile 
    1340                 1345                 1350             


Phe Ile  Phe Cys Phe Lys Leu  Leu Tyr Phe Met Glu  Leu Trp Leu 
    1355                 1360                 1365             


<210>  69
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Cys Gly Ser Ala Leu Ala Phe Phe Thr Ala Ala Phe Val Cys Leu 
1               5                   10                  15      


Gln Asn Asp Arg Arg Gly Pro Ala Ser Phe Leu Trp Ala Ala Trp Val 
            20                  25                  30          


Phe Ser Leu Val Leu Gly Leu Gly Gln Gly Glu Asp Asn Arg Cys Ala 
        35                  40                  45              


Ser Ser Asn Ala Ala Ser Cys Ala Arg Cys Leu Ala Leu Gly Pro Glu 
    50                  55                  60                  


Cys Gly Trp Cys Val Gln Glu Asp Phe Ile Ser Gly Gly Ser Arg Ser 
65                  70                  75                  80  


Glu Arg Cys Asp Ile Val Ser Asn Leu Ile Ser Lys Gly Cys Ser Val 
                85                  90                  95      


Asp Ser Ile Glu Tyr Pro Ser Val His Val Ile Ile Pro Thr Glu Asn 
            100                 105                 110         


Glu Ile Asn Thr Gln Val Thr Pro Gly Glu Val Ser Ile Gln Leu Arg 
        115                 120                 125             


Pro Gly Ala Glu Ala Asn Phe Met Leu Lys Val His Pro Leu Lys Lys 
    130                 135                 140                 


Tyr Pro Val Asp Leu Tyr Tyr Leu Val Asp Val Ser Ala Ser Met His 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Leu Asn Ser Val Gly Asn Asp Leu Ser Arg Lys 
                165                 170                 175     


Met Ala Phe Phe Ser Arg Asp Phe Arg Leu Gly Phe Gly Ser Tyr Val 
            180                 185                 190         


Asp Lys Thr Val Ser Pro Tyr Ile Ser Ile His Pro Glu Arg Ile His 
        195                 200                 205             


Asn Gln Cys Ser Asp Tyr Asn Leu Asp Cys Met Pro Pro His Gly Tyr 
    210                 215                 220                 


Ile His Val Leu Ser Leu Thr Glu Asn Ile Thr Glu Phe Glu Lys Ala 
225                 230                 235                 240 


Val His Arg Gln Lys Ile Ser Gly Asn Ile Asp Thr Pro Glu Gly Gly 
                245                 250                 255     


Phe Asp Ala Met Leu Gln Ala Ala Val Cys Glu Ser His Ile Gly Trp 
            260                 265                 270         


Arg Lys Glu Ala Lys Arg Leu Leu Leu Val Met Thr Asp Gln Thr Ser 
        275                 280                 285             


His Leu Ala Leu Asp Ser Lys Leu Ala Gly Ile Val Val Pro Asn Asp 
    290                 295                 300                 


Gly Asn Cys His Leu Lys Asn Asn Val Tyr Val Lys Ser Thr Thr Met 
305                 310                 315                 320 


Glu His Pro Ser Leu Gly Gln Leu Ser Glu Lys Leu Ile Asp Asn Asn 
                325                 330                 335     


Ile Asn Val Ile Phe Ala Val Gln Gly Lys Gln Phe His Trp Tyr Lys 
            340                 345                 350         


Asp Leu Leu Pro Leu Leu Pro Gly Thr Ile Ala Gly Glu Ile Glu Ser 
        355                 360                 365             


Lys Ala Ala Asn Leu Asn Asn Leu Val Val Glu Ala Tyr Gln Lys Leu 
    370                 375                 380                 


Ile Ser Glu Val Lys Val Gln Val Glu Asn Gln Val Gln Gly Ile Tyr 
385                 390                 395                 400 


Phe Asn Ile Thr Ala Ile Cys Pro Asp Gly Ser Arg Lys Pro Gly Met 
                405                 410                 415     


Glu Gly Cys Arg Asn Val Thr Ser Asn Asp Glu Val Leu Phe Asn Val 
            420                 425                 430         


Thr Val Thr Met Lys Lys Cys Asp Val Thr Gly Gly Lys Asn Tyr Ala 
        435                 440                 445             


Ile Ile Lys Pro Ile Gly Phe Asn Glu Thr Ala Lys Ile His Ile His 
    450                 455                 460                 


Arg Asn Cys Ser Cys Gln Cys Glu Asp Asn Arg Gly Pro Lys Gly Lys 
465                 470                 475                 480 


Cys Val Asp Glu Thr Phe Leu Asp Ser Lys Cys Phe Gln Cys Asp Glu 
                485                 490                 495     


Asn Lys Cys His Phe Asp Glu Asp Gln Phe Ser Ser Glu Ser Cys Lys 
            500                 505                 510         


Ser His Lys Asp Gln Pro Val Cys Ser Gly Arg Gly Val Cys Val Cys 
        515                 520                 525             


Gly Lys Cys Ser Cys His Lys Ile Lys Leu Gly Lys Val Tyr Gly Lys 
    530                 535                 540                 


Tyr Cys Glu Lys Asp Asp Phe Ser Cys Pro Tyr His His Gly Asn Leu 
545                 550                 555                 560 


Cys Ala Gly His Gly Glu Cys Glu Ala Gly Arg Cys Gln Cys Phe Ser 
                565                 570                 575     


Gly Trp Glu Gly Asp Arg Cys Gln Cys Pro Ser Ala Ala Ala Gln His 
            580                 585                 590         


Cys Val Asn Ser Lys Gly Gln Val Cys Ser Gly Arg Gly Thr Cys Val 
        595                 600                 605             


Cys Gly Arg Cys Glu Cys Thr Asp Pro Arg Ser Ile Gly Arg Phe Cys 
    610                 615                 620                 


Glu His Cys Pro Thr Cys Tyr Thr Ala Cys Lys Glu Asn Trp Asn Cys 
625                 630                 635                 640 


Met Gln Cys Leu His Pro His Asn Leu Ser Gln Ala Ile Leu Asp Gln 
                645                 650                 655     


Cys Lys Thr Ser Cys Ala Leu Met Glu Gln Gln His Tyr Val Asp Gln 
            660                 665                 670         


Thr Ser Glu Cys Phe Ser Ser Pro Ser Tyr Leu Arg Ile Phe Phe Ile 
        675                 680                 685             


Ile Phe Ile Val Thr Phe Leu Ile Gly Leu Leu Lys Val Leu Ile Ile 
    690                 695                 700                 


Arg Gln Val Ile Leu Gln Trp Asn Ser Asn Lys Ile Lys Ser Ser Ser 
705                 710                 715                 720 


Asp Tyr Arg Val Ser Ala Ser Lys Lys Asp Lys Leu Ile Leu Gln Ser 
                725                 730                 735     


Val Cys Thr Arg Ala Val Thr Tyr Arg Arg Glu Lys Pro Glu Glu Ile 
            740                 745                 750         


Lys Met Asp Ile Ser Lys Leu Asn Ala His Glu Thr Phe Arg Cys Asn 
        755                 760                 765             


Phe 
    


<210>  70
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Leu Val Leu Leu Ala Phe Ile Ile Ala Phe His Ile Thr Ser Ala 
1               5                   10                  15      


Ala Leu Leu Phe Ile Ala Thr Val Asp Asn Ala Trp Trp Val Gly Asp 
            20                  25                  30          


Glu Phe Phe Ala Asp Val Trp Arg Ile Cys Thr Asn Asn Thr Asn Cys 
        35                  40                  45              


Thr Val Ile Asn Asp Ser Phe Gln Glu Tyr Ser Thr Leu Gln Ala Val 
    50                  55                  60                  


Gln Ala Thr Met Ile Leu Ser Thr Ile Leu Cys Cys Ile Ala Phe Phe 
65                  70                  75                  80  


Ile Phe Val Leu Gln Leu Phe Arg Leu Lys Gln Gly Glu Arg Phe Val 
                85                  90                  95      


Leu Thr Ser Ile Ile Gln Leu Met Ser Cys Leu Cys Val Met Ile Ala 
            100                 105                 110         


Ala Ser Ile Tyr Thr Asp Arg Arg Glu Asp Ile His Asp Lys Asn Ala 
        115                 120                 125             


Lys Phe Tyr Pro Val Thr Arg Glu Gly Ser Tyr Gly Tyr Ser Tyr Ile 
    130                 135                 140                 


Leu Ala Trp Val Ala Phe Ala Cys Thr Phe Ile Ser Gly Met Met Tyr 
145                 150                 155                 160 


Leu Ile Leu Arg Lys Arg Lys 
                165         


<210>  71
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Lys Ile Cys Ser Leu Thr Leu Leu Ser Phe Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gln Val Leu Leu Val Glu Gly Lys Lys Lys Val Lys Asn Gly Leu His 
            20                  25                  30          


Ser Lys Val Val Ser Glu Gln Lys Asp Thr Leu Gly Asn Thr Gln Ile 
        35                  40                  45              


Lys Gln Lys Ser Arg Pro Gly Asn Lys Gly Lys Phe Val Thr Lys Asp 
    50                  55                  60                  


Gln Ala Asn Cys Arg Trp Ala Ala Thr Glu Gln Glu Glu Gly Ile Ser 
65                  70                  75                  80  


Leu Lys Val Glu Cys Thr Gln Leu Asp His Glu Phe Ser Cys Val Phe 
                85                  90                  95      


Ala Gly Asn Pro Thr Ser Cys Leu Lys Leu Lys Asp Glu Arg Val Tyr 
            100                 105                 110         


Trp Lys Gln Val Ala Arg Asn Leu Arg Ser Gln Lys Asp Ile Cys Arg 
        115                 120                 125             


Tyr Ser Lys Thr Ala Val Lys Thr Arg Val Cys Arg Lys Asp Phe Pro 
    130                 135                 140                 


Glu Ser Ser Leu Lys Leu Val Ser Ser Thr Leu Phe Gly Asn Thr Lys 
145                 150                 155                 160 


Pro Arg Lys Glu Lys Thr Glu Met Ser Pro Arg Glu His Ile Lys Gly 
                165                 170                 175     


Lys Glu Thr Thr Pro Ser Ser Leu Ala Val Thr Gln Thr Met Ala Thr 
            180                 185                 190         


Lys Ala Pro Glu Cys Val Glu Asp Pro Asp Met Ala Asn Gln Arg Lys 
        195                 200                 205             


Thr Ala Leu Glu Phe Cys Gly Glu Thr Trp Ser Ser Leu Cys Thr Phe 
    210                 215                 220                 


Phe Leu Ser Ile Val Gln Asp Thr Ser Cys 
225                 230                 


<210>  72
<211>  829
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Val 
1               5                   10                  15      


Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe Arg 
            20                  25                  30          


Glu Ala Glu Val Thr Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro Gly 
        35                  40                  45              


Gln Ala Leu Gly Lys Val Phe Met Gly Cys Pro Gly Gln Glu Pro Ala 
    50                  55                  60                  


Leu Phe Ser Thr Asp Asn Asp Asp Phe Thr Val Arg Asn Gly Glu Thr 
65                  70                  75                  80  


Val Gln Glu Arg Arg Ser Leu Lys Glu Arg Asn Pro Leu Lys Ile Phe 
                85                  90                  95      


Pro Ser Lys Arg Ile Leu Arg Arg His Lys Arg Asp Trp Val Val Ala 
            100                 105                 110         


Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro Phe Pro Gln Arg Leu 
        115                 120                 125             


Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Thr Lys Ile Phe Tyr Ser 
    130                 135                 140                 


Ile Thr Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe Ala Val 
145                 150                 155                 160 


Glu Lys Glu Thr Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp Arg Glu 
                165                 170                 175     


Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala Val Ser Glu Asn Gly 
            180                 185                 190         


Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile Ile Val Thr Asp Gln 
        195                 200                 205             


Asn Asp His Lys Pro Lys Phe Thr Gln Asp Thr Phe Arg Gly Ser Val 
    210                 215                 220                 


Leu Glu Gly Val Leu Pro Gly Thr Ser Val Met Gln Val Thr Ala Thr 
225                 230                 235                 240 


Asp Glu Asp Asp Ala Ile Tyr Thr Tyr Asn Gly Val Val Ala Tyr Ser 
                245                 250                 255     


Ile His Ser Gln Glu Pro Lys Asp Pro His Asp Leu Met Phe Thr Ile 
            260                 265                 270         


His Arg Ser Thr Gly Thr Ile Ser Val Ile Ser Ser Gly Leu Asp Arg 
        275                 280                 285             


Glu Lys Val Pro Glu Tyr Thr Leu Thr Ile Gln Ala Thr Asp Met Asp 
    290                 295                 300                 


Gly Asp Gly Ser Thr Thr Thr Ala Val Ala Val Val Glu Ile Leu Asp 
305                 310                 315                 320 


Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln Lys Tyr Glu Ala His 
                325                 330                 335     


Val Pro Glu Asn Ala Val Gly His Glu Val Gln Arg Leu Thr Val Thr 
            340                 345                 350         


Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg Ala Thr Tyr Leu Ile 
        355                 360                 365             


Met Gly Gly Asp Asp Gly Asp His Phe Thr Ile Thr Thr His Pro Glu 
    370                 375                 380                 


Ser Asn Gln Gly Ile Leu Thr Thr Arg Lys Gly Leu Asp Phe Glu Ala 
385                 390                 395                 400 


Lys Asn Gln His Thr Leu Tyr Val Glu Val Thr Asn Glu Ala Pro Phe 
                405                 410                 415     


Val Leu Lys Leu Pro Thr Ser Thr Ala Thr Ile Val Val His Val Glu 
            420                 425                 430         


Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro Ser Lys Val Val Glu 
        435                 440                 445             


Val Gln Glu Gly Ile Pro Thr Gly Glu Pro Val Cys Val Tyr Thr Ala 
    450                 455                 460                 


Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser Tyr Arg Ile Leu Arg 
465                 470                 475                 480 


Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp Ser Gly Gln Val Thr 
                485                 490                 495     


Ala Val Gly Thr Leu Asp Arg Glu Asp Glu Gln Phe Val Arg Asn Asn 
            500                 505                 510         


Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn Gly Ser Pro Pro Thr 
        515                 520                 525             


Thr Gly Thr Gly Thr Leu Leu Leu Thr Leu Ile Asp Val Asn Asp His 
    530                 535                 540                 


Gly Pro Val Pro Glu Pro Arg Gln Ile Thr Ile Cys Asn Gln Ser Pro 
545                 550                 555                 560 


Val Arg Gln Val Leu Asn Ile Thr Asp Lys Asp Leu Ser Pro His Thr 
                565                 570                 575     


Ser Pro Phe Gln Ala Gln Leu Thr Asp Asp Ser Asp Ile Tyr Trp Thr 
            580                 585                 590         


Ala Glu Val Asn Glu Glu Gly Asp Thr Val Val Leu Ser Leu Lys Lys 
        595                 600                 605             


Phe Leu Lys Gln Asp Thr Tyr Asp Val His Leu Ser Leu Ser Asp His 
    610                 615                 620                 


Gly Asn Lys Glu Gln Leu Thr Val Ile Arg Ala Thr Val Cys Asp Cys 
625                 630                 635                 640 


His Gly His Val Glu Thr Cys Pro Gly Pro Trp Lys Gly Gly Phe Ile 
                645                 650                 655     


Leu Pro Val Leu Gly Ala Val Leu Ala Leu Leu Phe Leu Leu Leu Val 
            660                 665                 670         


Leu Leu Leu Leu Val Arg Lys Lys Arg Lys Ile Lys Glu Pro Leu Leu 
        675                 680                 685             


Leu Pro Glu Asp Asp Thr Arg Asp Asn Val Phe Tyr Tyr Gly Glu Glu 
    690                 695                 700                 


Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Ile Thr Gln Leu His Arg 
705                 710                 715                 720 


Gly Leu Glu Ala Arg Pro Glu Val Val Leu Arg Asn Asp Val Ala Pro 
                725                 730                 735     


Thr Ile Ile Pro Thr Pro Met Tyr Arg Pro Arg Pro Ala Asn Pro Asp 
            740                 745                 750         


Glu Ile Gly Asn Phe Ile Ile Glu Asn Leu Lys Ala Ala Asn Thr Asp 
        755                 760                 765             


Pro Thr Ala Pro Pro Tyr Asp Thr Leu Leu Val Phe Asp Tyr Glu Gly 
    770                 775                 780                 


Ser Gly Ser Asp Ala Ala Ser Leu Ser Ser Leu Thr Ser Ser Ala Ser 
785                 790                 795                 800 


Asp Gln Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Ser Arg Phe 
                805                 810                 815     


Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
            820                 825                 


<210>  73
<211>  1822
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                  25                  30          


Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                  40                  45              


Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                  55                  60                  


Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                  70                  75                  80  


Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                  90                  95      


Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                 105                 110         


Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                 120                 125             


Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                 135                 140                 


Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                 150                 155                 160 


Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                 170                 175     


Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                 185                 190         


Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                 200                 205             


Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                 215                 220                 


Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                 230                 235                 240 


Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                 250                 255     


His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                 265                 270         


Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                 280                 285             


His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                 295                 300                 


Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                 310                 315                 320 


Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                 330                 335     


His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                 345                 350         


Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                 360                 365             


Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                 375                 380                 


Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                 390                 395                 400 


Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                 410                 415     


His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                 425                 430         


Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                 440                 445             


Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                 455                 460                 


Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                 470                 475                 480 


Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                 490                 495     


Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                 505                 510         


Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                 520                 525             


Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                 535                 540                 


Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                 550                 555                 560 


Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                 570                 575     


Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                 585                 590         


Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                 600                 605             


Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                 615                 620                 


Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                 630                 635                 640 


Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                 650                 655     


Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                 665                 670         


Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                 680                 685             


Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                 695                 700                 


Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                 730                 735     


Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                 745                 750         


His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                 760                 765             


Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                 775                 780                 


Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                 790                 795                 800 


Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                 810                 815     


Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                 825                 830         


Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                 840                 845             


Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                 855                 860                 


Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                 870                 875                 880 


His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                 890                 895     


Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                 905                 910         


Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                 920                 925             


Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                 935                 940                 


Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                 950                 955                 960 


Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                 970                 975     


Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                 985                 990         


Ser Phe Glu Gln Pro Glu Phe Ser  Val Ser Arg Gly Asp  Gln Val Ala 
        995                 1000                 1005             


Arg Ile  Pro Val Ile Arg Arg  Val Leu Asp Gly Gly  Lys Ser Gln 
    1010                 1015                 1020             


Val Ser  Tyr Arg Thr Gln Asp  Gly Thr Ala Gln Gly  Asn Arg Asp 
    1025                 1030                 1035             


Tyr Ile  Pro Val Glu Gly Glu  Leu Leu Phe Gln Pro  Gly Glu Ala 
    1040                 1045                 1050             


Trp Lys  Glu Leu Gln Val Lys  Leu Leu Glu Leu Gln  Glu Val Asp 
    1055                 1060                 1065             


Ser Leu  Leu Arg Gly Arg Gln  Val Arg Arg Phe His  Val Gln Leu 
    1070                 1075                 1080             


Ser Asn  Pro Lys Phe Gly Ala  His Leu Gly Gln Pro  His Ser Thr 
    1085                 1090                 1095             


Thr Ile  Ile Ile Arg Asp Pro  Asp Glu Leu Asp Arg  Ser Phe Thr 
    1100                 1105                 1110             


Ser Gln  Met Leu Ser Ser Gln  Pro Pro Pro His Gly  Asp Leu Gly 
    1115                 1120                 1125             


Ala Pro  Gln Asn Pro Asn Ala  Lys Ala Ala Gly Ser  Arg Lys Ile 
    1130                 1135                 1140             


His Phe  Asn Trp Leu Pro Pro  Ser Gly Lys Pro Met  Gly Tyr Arg 
    1145                 1150                 1155             


Val Lys  Tyr Trp Ile Gln Gly  Asp Ser Glu Ser Glu  Ala His Leu 
    1160                 1165                 1170             


Leu Asp  Ser Lys Val Pro Ser  Val Glu Leu Thr Asn  Leu Tyr Pro 
    1175                 1180                 1185             


Tyr Cys  Asp Tyr Glu Met Lys  Val Cys Ala Tyr Gly  Ala Gln Gly 
    1190                 1195                 1200             


Glu Gly  Pro Tyr Ser Ser Leu  Val Ser Cys Arg Thr  His Gln Glu 
    1205                 1210                 1215             


Val Pro  Ser Glu Pro Gly Arg  Leu Ala Phe Asn Val  Val Ser Ser 
    1220                 1225                 1230             


Thr Val  Thr Gln Leu Ser Trp  Ala Glu Pro Ala Glu  Thr Asn Gly 
    1235                 1240                 1245             


Glu Ile  Thr Ala Tyr Glu Val  Cys Tyr Gly Leu Val  Asn Asp Asp 
    1250                 1255                 1260             


Asn Arg  Pro Ile Gly Pro Met  Lys Lys Val Leu Val  Asp Asn Pro 
    1265                 1270                 1275             


Lys Asn  Arg Met Leu Leu Ile  Glu Asn Leu Arg Glu  Ser Gln Pro 
    1280                 1285                 1290             


Tyr Arg  Tyr Thr Val Lys Ala  Arg Asn Gly Ala Gly  Trp Gly Pro 
    1295                 1300                 1305             


Glu Arg  Glu Ala Ile Ile Asn  Leu Ala Thr Gln Pro  Lys Arg Pro 
    1310                 1315                 1320             


Met Ser  Ile Pro Ile Ile Pro  Asp Ile Pro Ile Val  Asp Ala Gln 
    1325                 1330                 1335             


Ser Gly  Glu Asp Tyr Asp Ser  Phe Leu Met Tyr Ser  Asp Asp Val 
    1340                 1345                 1350             


Leu Arg  Ser Pro Ser Gly Ser  Gln Arg Pro Ser Val  Ser Asp Asp 
    1355                 1360                 1365             


Thr Gly  Cys Gly Trp Lys Phe  Glu Pro Leu Leu Gly  Glu Glu Leu 
    1370                 1375                 1380             


Asp Leu  Arg Arg Val Thr Trp  Arg Leu Pro Pro Glu  Leu Ile Pro 
    1385                 1390                 1395             


Arg Leu  Ser Ala Ser Ser Gly  Arg Ser Ser Asp Ala  Glu Ala Pro 
    1400                 1405                 1410             


His Gly  Pro Pro Asp Asp Gly  Gly Ala Gly Gly Lys  Gly Gly Ser 
    1415                 1420                 1425             


Leu Pro  Arg Ser Ala Thr Pro  Gly Pro Pro Gly Glu  His Leu Val 
    1430                 1435                 1440             


Asn Gly  Arg Met Asp Phe Ala  Phe Pro Gly Ser Thr  Asn Ser Leu 
    1445                 1450                 1455             


His Arg  Met Thr Thr Thr Ser  Ala Ala Ala Tyr Gly  Thr His Leu 
    1460                 1465                 1470             


Ser Pro  His Val Pro His Arg  Val Leu Ser Thr Ser  Ser Thr Leu 
    1475                 1480                 1485             


Thr Arg  Asp Tyr Asn Ser Leu  Thr Arg Ser Glu His  Ser His Ser 
    1490                 1495                 1500             


Thr Thr  Leu Pro Arg Asp Tyr  Ser Thr Leu Thr Ser  Val Ser Ser 
    1505                 1510                 1515             


His Asp  Ser Arg Leu Thr Ala  Gly Val Pro Asp Thr  Pro Thr Arg 
    1520                 1525                 1530             


Leu Val  Phe Ser Ala Leu Gly  Pro Thr Ser Leu Arg  Val Ser Trp 
    1535                 1540                 1545             


Gln Glu  Pro Arg Cys Glu Arg  Pro Leu Gln Gly Tyr  Ser Val Glu 
    1550                 1555                 1560             


Tyr Gln  Leu Leu Asn Gly Gly  Glu Leu His Arg Leu  Asn Ile Pro 
    1565                 1570                 1575             


Asn Pro  Ala Gln Thr Ser Val  Val Val Glu Asp Leu  Leu Pro Asn 
    1580                 1585                 1590             


His Ser  Tyr Val Phe Arg Val  Arg Ala Gln Ser Gln  Glu Gly Trp 
    1595                 1600                 1605             


Gly Arg  Glu Arg Glu Gly Val  Ile Thr Ile Glu Ser  Gln Val His 
    1610                 1615                 1620             


Pro Gln  Ser Pro Leu Cys Pro  Leu Pro Gly Ser Ala  Phe Thr Leu 
    1625                 1630                 1635             


Ser Thr  Pro Ser Ala Pro Gly  Pro Leu Val Phe Thr  Ala Leu Ser 
    1640                 1645                 1650             


Pro Asp  Ser Leu Gln Leu Ser  Trp Glu Arg Pro Arg  Arg Pro Asn 
    1655                 1660                 1665             


Gly Asp  Ile Val Gly Tyr Leu  Val Thr Cys Glu Met  Ala Gln Gly 
    1670                 1675                 1680             


Gly Gly  Pro Ala Thr Ala Phe  Arg Val Asp Gly Asp  Ser Pro Glu 
    1685                 1690                 1695             


Ser Arg  Leu Thr Val Pro Gly  Leu Ser Glu Asn Val  Pro Tyr Lys 
    1700                 1705                 1710             


Phe Lys  Val Gln Ala Arg Thr  Thr Glu Gly Phe Gly  Pro Glu Arg 
    1715                 1720                 1725             


Glu Gly  Ile Ile Thr Ile Glu  Ser Gln Asp Gly Gly  Pro Phe Pro 
    1730                 1735                 1740             


Gln Leu  Gly Ser Arg Ala Gly  Leu Phe Gln His Pro  Leu Gln Ser 
    1745                 1750                 1755             


Glu Tyr  Ser Ser Ile Thr Thr  Thr His Thr Ser Ala  Thr Glu Pro 
    1760                 1765                 1770             


Phe Leu  Val Asp Gly Leu Thr  Leu Gly Ala Gln His  Leu Glu Ala 
    1775                 1780                 1785             


Gly Gly  Ser Leu Thr Arg His  Val Thr Gln Glu Phe  Val Ser Arg 
    1790                 1795                 1800             


Thr Leu  Thr Thr Ser Gly Thr  Leu Ser Thr His Met  Asp Gln Gln 
    1805                 1810                 1815             


Phe Phe  Gln Thr 
    1820         


<210>  74
<211>  1805
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                  25                  30          


Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                  40                  45              


Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                  55                  60                  


Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                  70                  75                  80  


Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                  90                  95      


Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                 105                 110         


Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                 120                 125             


Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                 135                 140                 


Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                 150                 155                 160 


Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                 170                 175     


Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                 185                 190         


Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                 200                 205             


Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                 215                 220                 


Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                 230                 235                 240 


Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                 250                 255     


His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                 265                 270         


Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                 280                 285             


His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                 295                 300                 


Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                 310                 315                 320 


Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                 330                 335     


His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                 345                 350         


Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                 360                 365             


Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                 375                 380                 


Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                 390                 395                 400 


Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                 410                 415     


His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                 425                 430         


Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                 440                 445             


Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                 455                 460                 


Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                 470                 475                 480 


Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                 490                 495     


Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                 505                 510         


Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                 520                 525             


Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                 535                 540                 


Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                 550                 555                 560 


Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                 570                 575     


Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                 585                 590         


Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                 600                 605             


Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                 615                 620                 


Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                 630                 635                 640 


Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                 650                 655     


Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                 665                 670         


Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                 680                 685             


Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                 695                 700                 


Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                 730                 735     


Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                 745                 750         


His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                 760                 765             


Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                 775                 780                 


Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                 790                 795                 800 


Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                 810                 815     


Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                 825                 830         


Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                 840                 845             


Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                 855                 860                 


Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                 870                 875                 880 


His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                 890                 895     


Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                 905                 910         


Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                 920                 925             


Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                 935                 940                 


Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                 950                 955                 960 


Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                 970                 975     


Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                 985                 990         


Ser Phe Glu Gln Pro Glu Phe Ser  Val Ser Arg Gly Asp  Gln Val Ala 
        995                 1000                 1005             


Arg Ile  Pro Val Ile Arg Arg  Val Leu Asp Gly Gly  Lys Ser Gln 
    1010                 1015                 1020             


Val Ser  Tyr Arg Thr Gln Asp  Gly Thr Ala Gln Gly  Asn Arg Asp 
    1025                 1030                 1035             


Tyr Ile  Pro Val Glu Gly Glu  Leu Leu Phe Gln Pro  Gly Glu Ala 
    1040                 1045                 1050             


Trp Lys  Glu Leu Gln Val Lys  Leu Leu Glu Leu Gln  Glu Val Asp 
    1055                 1060                 1065             


Ser Leu  Leu Arg Gly Arg Gln  Val Arg Arg Phe His  Val Gln Leu 
    1070                 1075                 1080             


Ser Asn  Pro Lys Phe Gly Ala  His Leu Gly Gln Pro  His Ser Thr 
    1085                 1090                 1095             


Thr Ile  Ile Ile Arg Asp Pro  Asp Glu Leu Asp Arg  Ser Phe Thr 
    1100                 1105                 1110             


Ser Gln  Met Leu Ser Ser Gln  Pro Pro Pro His Gly  Asp Leu Gly 
    1115                 1120                 1125             


Ala Pro  Gln Asn Pro Asn Ala  Lys Ala Ala Gly Ser  Arg Lys Ile 
    1130                 1135                 1140             


His Phe  Asn Trp Leu Pro Pro  Ser Gly Lys Pro Met  Gly Tyr Arg 
    1145                 1150                 1155             


Val Lys  Tyr Trp Ile Gln Gly  Asp Ser Glu Ser Glu  Ala His Leu 
    1160                 1165                 1170             


Leu Asp  Ser Lys Val Pro Ser  Val Glu Leu Thr Asn  Leu Tyr Pro 
    1175                 1180                 1185             


Tyr Cys  Asp Tyr Glu Met Lys  Val Cys Ala Tyr Gly  Ala Gln Gly 
    1190                 1195                 1200             


Glu Gly  Pro Tyr Ser Ser Leu  Val Ser Cys Arg Thr  His Gln Glu 
    1205                 1210                 1215             


Val Pro  Ser Glu Pro Gly Arg  Leu Ala Phe Asn Val  Val Ser Ser 
    1220                 1225                 1230             


Thr Val  Thr Gln Leu Ser Trp  Ala Glu Pro Ala Glu  Thr Asn Gly 
    1235                 1240                 1245             


Glu Ile  Thr Ala Tyr Glu Val  Cys Tyr Gly Leu Val  Asn Asp Asp 
    1250                 1255                 1260             


Asn Arg  Pro Ile Gly Pro Met  Lys Lys Val Leu Val  Asp Asn Pro 
    1265                 1270                 1275             


Lys Asn  Arg Met Leu Leu Ile  Glu Asn Leu Arg Glu  Ser Gln Pro 
    1280                 1285                 1290             


Tyr Arg  Tyr Thr Val Lys Ala  Arg Asn Gly Ala Gly  Trp Gly Pro 
    1295                 1300                 1305             


Glu Arg  Glu Ala Ile Ile Asn  Leu Ala Thr Gln Pro  Lys Arg Pro 
    1310                 1315                 1320             


Met Ser  Ile Pro Ile Ile Pro  Asp Ile Pro Ile Val  Asp Ala Gln 
    1325                 1330                 1335             


Ser Gly  Glu Asp Tyr Asp Ser  Phe Leu Met Tyr Ser  Asp Asp Val 
    1340                 1345                 1350             


Leu Arg  Ser Pro Ser Gly Ser  Gln Arg Pro Ser Val  Ser Asp Asp 
    1355                 1360                 1365             


Thr Glu  His Leu Val Asn Gly  Arg Met Asp Phe Ala  Phe Pro Gly 
    1370                 1375                 1380             


Ser Thr  Asn Ser Leu His Arg  Met Thr Thr Thr Ser  Ala Ala Ala 
    1385                 1390                 1395             


Tyr Gly  Thr His Leu Ser Pro  His Val Pro His Arg  Val Leu Ser 
    1400                 1405                 1410             


Thr Ser  Ser Thr Leu Thr Arg  Asp Tyr Asn Ser Leu  Thr Arg Ser 
    1415                 1420                 1425             


Glu His  Ser His Ser Thr Thr  Leu Pro Arg Asp Tyr  Ser Thr Leu 
    1430                 1435                 1440             


Thr Ser  Val Ser Ser His Gly  Leu Pro Pro Ile Trp  Glu His Gly 
    1445                 1450                 1455             


Arg Ser  Arg Leu Pro Leu Ser  Trp Ala Leu Gly Ser  Arg Ser Arg 
    1460                 1465                 1470             


Ala Gln  Met Lys Gly Phe Pro  Pro Ser Arg Gly Pro  Arg Asp Ser 
    1475                 1480                 1485             


Ile Ile  Leu Ala Gly Arg Pro  Ala Ala Pro Ser Trp  Gly Pro Asp 
    1490                 1495                 1500             


Ser Arg  Leu Thr Ala Gly Val  Pro Asp Thr Pro Thr  Arg Leu Val 
    1505                 1510                 1515             


Phe Ser  Ala Leu Gly Pro Thr  Ser Leu Arg Val Ser  Trp Gln Glu 
    1520                 1525                 1530             


Pro Arg  Cys Glu Arg Pro Leu  Gln Gly Tyr Ser Val  Glu Tyr Gln 
    1535                 1540                 1545             


Leu Leu  Asn Gly Gly Glu Leu  His Arg Leu Asn Ile  Pro Asn Pro 
    1550                 1555                 1560             


Ala Gln  Thr Ser Val Val Val  Glu Asp Leu Leu Pro  Asn His Ser 
    1565                 1570                 1575             


Tyr Val  Phe Arg Val Arg Ala  Gln Ser Gln Glu Gly  Trp Gly Arg 
    1580                 1585                 1590             


Glu Arg  Glu Gly Val Ile Thr  Ile Glu Ser Gln Val  His Pro Gln 
    1595                 1600                 1605             


Ser Pro  Leu Cys Pro Leu Pro  Gly Ser Ala Phe Thr  Leu Ser Thr 
    1610                 1615                 1620             


Pro Ser  Ala Pro Gly Pro Leu  Val Phe Thr Ala Leu  Ser Pro Asp 
    1625                 1630                 1635             


Ser Leu  Gln Leu Ser Trp Glu  Arg Pro Arg Arg Pro  Asn Gly Asp 
    1640                 1645                 1650             


Ile Val  Gly Tyr Leu Val Thr  Cys Glu Met Ala Gln  Gly Gly Gly 
    1655                 1660                 1665             


Pro Ala  Thr Ala Phe Arg Val  Asp Gly Asp Ser Pro  Glu Ser Arg 
    1670                 1675                 1680             


Leu Thr  Val Pro Gly Leu Ser  Glu Asn Val Pro Tyr  Lys Phe Lys 
    1685                 1690                 1695             


Val Gln  Ala Arg Thr Thr Glu  Gly Phe Gly Pro Glu  Arg Glu Gly 
    1700                 1705                 1710             


Ile Ile  Thr Ile Glu Ser Gln  Asp Gly Gly Pro Phe  Pro Gln Leu 
    1715                 1720                 1725             


Gly Ser  Arg Ala Gly Leu Phe  Gln His Pro Leu Gln  Ser Glu Tyr 
    1730                 1735                 1740             


Ser Ser  Ile Thr Thr Thr His  Thr Ser Ala Thr Glu  Pro Phe Leu 
    1745                 1750                 1755             


Val Asp  Gly Leu Thr Leu Gly  Ala Gln His Leu Glu  Ala Gly Gly 
    1760                 1765                 1770             


Ser Leu  Thr Arg His Val Thr  Gln Glu Phe Val Ser  Arg Thr Leu 
    1775                 1780                 1785             


Thr Thr  Ser Gly Thr Leu Ser  Thr His Met Asp Gln  Gln Phe Phe 
    1790                 1795                 1800             


Gln Thr  
    1805 


<210>  75
<211>  1752
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                  25                  30          


Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                  40                  45              


Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                  55                  60                  


Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                  70                  75                  80  


Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                  90                  95      


Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                 105                 110         


Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                 120                 125             


Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                 135                 140                 


Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                 150                 155                 160 


Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                 170                 175     


Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                 185                 190         


Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                 200                 205             


Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                 215                 220                 


Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                 230                 235                 240 


Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                 250                 255     


His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                 265                 270         


Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                 280                 285             


His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                 295                 300                 


Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                 310                 315                 320 


Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                 330                 335     


His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                 345                 350         


Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                 360                 365             


Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                 375                 380                 


Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                 390                 395                 400 


Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                 410                 415     


His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                 425                 430         


Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                 440                 445             


Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                 455                 460                 


Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                 470                 475                 480 


Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                 490                 495     


Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                 505                 510         


Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                 520                 525             


Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                 535                 540                 


Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                 550                 555                 560 


Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                 570                 575     


Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                 585                 590         


Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                 600                 605             


Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                 615                 620                 


Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                 630                 635                 640 


Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                 650                 655     


Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                 665                 670         


Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                 680                 685             


Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                 695                 700                 


Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                 730                 735     


Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                 745                 750         


His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                 760                 765             


Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                 775                 780                 


Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                 790                 795                 800 


Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                 810                 815     


Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                 825                 830         


Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                 840                 845             


Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                 855                 860                 


Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                 870                 875                 880 


His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                 890                 895     


Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                 905                 910         


Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                 920                 925             


Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                 935                 940                 


Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                 950                 955                 960 


Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                 970                 975     


Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                 985                 990         


Ser Phe Glu Gln Pro Glu Phe Ser  Val Ser Arg Gly Asp  Gln Val Ala 
        995                 1000                 1005             


Arg Ile  Pro Val Ile Arg Arg  Val Leu Asp Gly Gly  Lys Ser Gln 
    1010                 1015                 1020             


Val Ser  Tyr Arg Thr Gln Asp  Gly Thr Ala Gln Gly  Asn Arg Asp 
    1025                 1030                 1035             


Tyr Ile  Pro Val Glu Gly Glu  Leu Leu Phe Gln Pro  Gly Glu Ala 
    1040                 1045                 1050             


Trp Lys  Glu Leu Gln Val Lys  Leu Leu Glu Leu Gln  Glu Val Asp 
    1055                 1060                 1065             


Ser Leu  Leu Arg Gly Arg Gln  Val Arg Arg Phe His  Val Gln Leu 
    1070                 1075                 1080             


Ser Asn  Pro Lys Phe Gly Ala  His Leu Gly Gln Pro  His Ser Thr 
    1085                 1090                 1095             


Thr Ile  Ile Ile Arg Asp Pro  Asp Glu Leu Asp Arg  Ser Phe Thr 
    1100                 1105                 1110             


Ser Gln  Met Leu Ser Ser Gln  Pro Pro Pro His Gly  Asp Leu Gly 
    1115                 1120                 1125             


Ala Pro  Gln Asn Pro Asn Ala  Lys Ala Ala Gly Ser  Arg Lys Ile 
    1130                 1135                 1140             


His Phe  Asn Trp Leu Pro Pro  Ser Gly Lys Pro Met  Gly Tyr Arg 
    1145                 1150                 1155             


Val Lys  Tyr Trp Ile Gln Gly  Asp Ser Glu Ser Glu  Ala His Leu 
    1160                 1165                 1170             


Leu Asp  Ser Lys Val Pro Ser  Val Glu Leu Thr Asn  Leu Tyr Pro 
    1175                 1180                 1185             


Tyr Cys  Asp Tyr Glu Met Lys  Val Cys Ala Tyr Gly  Ala Gln Gly 
    1190                 1195                 1200             


Glu Gly  Pro Tyr Ser Ser Leu  Val Ser Cys Arg Thr  His Gln Glu 
    1205                 1210                 1215             


Val Pro  Ser Glu Pro Gly Arg  Leu Ala Phe Asn Val  Val Ser Ser 
    1220                 1225                 1230             


Thr Val  Thr Gln Leu Ser Trp  Ala Glu Pro Ala Glu  Thr Asn Gly 
    1235                 1240                 1245             


Glu Ile  Thr Ala Tyr Glu Val  Cys Tyr Gly Leu Val  Asn Asp Asp 
    1250                 1255                 1260             


Asn Arg  Pro Ile Gly Pro Met  Lys Lys Val Leu Val  Asp Asn Pro 
    1265                 1270                 1275             


Lys Asn  Arg Met Leu Leu Ile  Glu Asn Leu Arg Glu  Ser Gln Pro 
    1280                 1285                 1290             


Tyr Arg  Tyr Thr Val Lys Ala  Arg Asn Gly Ala Gly  Trp Gly Pro 
    1295                 1300                 1305             


Glu Arg  Glu Ala Ile Ile Asn  Leu Ala Thr Gln Pro  Lys Arg Pro 
    1310                 1315                 1320             


Met Ser  Ile Pro Ile Ile Pro  Asp Ile Pro Ile Val  Asp Ala Gln 
    1325                 1330                 1335             


Ser Gly  Glu Asp Tyr Asp Ser  Phe Leu Met Tyr Ser  Asp Asp Val 
    1340                 1345                 1350             


Leu Arg  Ser Pro Ser Gly Ser  Gln Arg Pro Ser Val  Ser Asp Asp 
    1355                 1360                 1365             


Thr Glu  His Leu Val Asn Gly  Arg Met Asp Phe Ala  Phe Pro Gly 
    1370                 1375                 1380             


Ser Thr  Asn Ser Leu His Arg  Met Thr Thr Thr Ser  Ala Ala Ala 
    1385                 1390                 1395             


Tyr Gly  Thr His Leu Ser Pro  His Val Pro His Arg  Val Leu Ser 
    1400                 1405                 1410             


Thr Ser  Ser Thr Leu Thr Arg  Asp Tyr Asn Ser Leu  Thr Arg Ser 
    1415                 1420                 1425             


Glu His  Ser His Ser Thr Thr  Leu Pro Arg Asp Tyr  Ser Thr Leu 
    1430                 1435                 1440             


Thr Ser  Val Ser Ser His Asp  Ser Arg Leu Thr Ala  Gly Val Pro 
    1445                 1450                 1455             


Asp Thr  Pro Thr Arg Leu Val  Phe Ser Ala Leu Gly  Pro Thr Ser 
    1460                 1465                 1470             


Leu Arg  Val Ser Trp Gln Glu  Pro Arg Cys Glu Arg  Pro Leu Gln 
    1475                 1480                 1485             


Gly Tyr  Ser Val Glu Tyr Gln  Leu Leu Asn Gly Gly  Glu Leu His 
    1490                 1495                 1500             


Arg Leu  Asn Ile Pro Asn Pro  Ala Gln Thr Ser Val  Val Val Glu 
    1505                 1510                 1515             


Asp Leu  Leu Pro Asn His Ser  Tyr Val Phe Arg Val  Arg Ala Gln 
    1520                 1525                 1530             


Ser Gln  Glu Gly Trp Gly Arg  Glu Arg Glu Gly Val  Ile Thr Ile 
    1535                 1540                 1545             


Glu Ser  Gln Val His Pro Gln  Ser Pro Leu Cys Pro  Leu Pro Gly 
    1550                 1555                 1560             


Ser Ala  Phe Thr Leu Ser Thr  Pro Ser Ala Pro Gly  Pro Leu Val 
    1565                 1570                 1575             


Phe Thr  Ala Leu Ser Pro Asp  Ser Leu Gln Leu Ser  Trp Glu Arg 
    1580                 1585                 1590             


Pro Arg  Arg Pro Asn Gly Asp  Ile Val Gly Tyr Leu  Val Thr Cys 
    1595                 1600                 1605             


Glu Met  Ala Gln Gly Gly Gly  Pro Ala Thr Ala Phe  Arg Val Asp 
    1610                 1615                 1620             


Gly Asp  Ser Pro Glu Ser Arg  Leu Thr Val Pro Gly  Leu Ser Glu 
    1625                 1630                 1635             


Asn Val  Pro Tyr Lys Phe Lys  Val Gln Ala Arg Thr  Thr Glu Gly 
    1640                 1645                 1650             


Phe Gly  Pro Glu Arg Glu Gly  Ile Ile Thr Ile Glu  Ser Gln Asp 
    1655                 1660                 1665             


Gly Gly  Pro Phe Pro Gln Leu  Gly Ser Arg Ala Gly  Leu Phe Gln 
    1670                 1675                 1680             


His Pro  Leu Gln Ser Glu Tyr  Ser Ser Ile Thr Thr  Thr His Thr 
    1685                 1690                 1695             


Ser Ala  Thr Glu Pro Phe Leu  Val Asp Gly Leu Thr  Leu Gly Ala 
    1700                 1705                 1710             


Gln His  Leu Glu Ala Gly Gly  Ser Leu Thr Arg His  Val Thr Gln 
    1715                 1720                 1725             


Glu Phe  Val Ser Arg Thr Leu  Thr Thr Ser Gly Thr  Leu Ser Thr 
    1730                 1735                 1740             


His Met  Asp Gln Gln Phe Phe  Gln Thr 
    1745                 1750         


<210>  76
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Arg Pro Phe Phe Leu Leu Cys Phe Ala Leu Pro Gly Leu Leu His 
1               5                   10                  15      


Ala Gln Gln Ala Cys Ser Arg Gly Ala Cys Tyr Pro Pro Val Gly Asp 
            20                  25                  30          


Leu Leu Val Gly Arg Thr Arg Phe Leu Arg Ala Ser Ser Thr Cys Gly 
        35                  40                  45              


Leu Thr Lys Pro Glu Thr Tyr Cys Thr Gln Tyr Gly Glu Trp Gln Met 
    50                  55                  60                  


Lys Cys Cys Lys Cys Asp Ser Arg Gln Pro His Asn Tyr Tyr Ser His 
65                  70                  75                  80  


Arg Val Glu Asn Val Ala Ser Ser Ser Gly Pro Met Arg Trp Trp Gln 
                85                  90                  95      


Ser Gln Asn Asp Val Asn Pro Val Ser Leu Gln Leu Asp Leu Asp Arg 
            100                 105                 110         


Arg Phe Gln Leu Gln Glu Val Met Met Glu Phe Gln Gly Pro Met Pro 
        115                 120                 125             


Ala Gly Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Thr Trp Arg 
    130                 135                 140                 


Val Tyr Gln Tyr Leu Ala Ala Asp Cys Thr Ser Thr Phe Pro Arg Val 
145                 150                 155                 160 


Arg Gln Gly Arg Pro Gln Ser Trp Gln Asp Val Arg Cys Gln Ser Leu 
                165                 170                 175     


Pro Gln Arg Pro Asn Ala Arg Leu Asn Gly Gly Lys Val Gln Leu Asn 
            180                 185                 190         


Leu Met Asp Leu Val Ser Gly Ile Pro Ala Thr Gln Ser Gln Lys Ile 
        195                 200                 205             


Gln Glu Val Gly Glu Ile Thr Asn Leu Arg Val Asn Phe Thr Arg Leu 
    210                 215                 220                 


Ala Pro Val Pro Gln Arg Gly Tyr His Pro Pro Ser Ala Tyr Tyr Ala 
225                 230                 235                 240 


Val Ser Gln Leu Arg Leu Gln Gly Ser Cys Phe Cys His Gly His Ala 
                245                 250                 255     


Asp Arg Cys Ala Pro Lys Pro Gly Ala Ser Ala Gly Pro Ser Thr Ala 
            260                 265                 270         


Val Gln Val His Asp Val Cys Val Cys Gln His Asn Thr Ala Gly Pro 
        275                 280                 285             


Asn Cys Glu Arg Cys Ala Pro Phe Tyr Asn Asn Arg Pro Trp Arg Pro 
    290                 295                 300                 


Ala Glu Gly Gln Asp Ala His Glu Cys Gln Arg Cys Asp Cys Asn Gly 
305                 310                 315                 320 


His Ser Glu Thr Cys His Phe Asp Pro Ala Val Phe Ala Ala Ser Gln 
                325                 330                 335     


Gly Ala Tyr Gly Gly Val Cys Asp Asn Cys Arg Asp His Thr Glu Gly 
            340                 345                 350         


Lys Asn Cys Glu Arg Cys Gln Leu His Tyr Phe Arg Asn Arg Arg Pro 
        355                 360                 365             


Gly Ala Ser Ile Gln Glu Thr Cys Ile Ser Cys Glu Cys Asp Pro Asp 
    370                 375                 380                 


Gly Ala Val Pro Gly Ala Pro Cys Asp Pro Val Thr Gly Gln Cys Val 
385                 390                 395                 400 


Cys Lys Glu His Val Gln Gly Glu Arg Cys Asp Leu Cys Lys Pro Gly 
                405                 410                 415     


Phe Thr Gly Leu Thr Tyr Ala Asn Pro Gln Gly Cys His Arg Cys Asp 
            420                 425                 430         


Cys Asn Ile Leu Gly Ser Arg Arg Asp Met Pro Cys Asp Glu Glu Ser 
        435                 440                 445             


Gly Arg Cys Leu Cys Leu Pro Asn Val Val Gly Pro Lys Cys Asp Gln 
    450                 455                 460                 


Cys Ala Pro Tyr His Trp Lys Leu Ala Ser Gly Gln Gly Cys Glu Pro 
465                 470                 475                 480 


Cys Ala Cys Asp Pro His Asn Ser Leu Ser Pro Gln Cys Asn Gln Phe 
                485                 490                 495     


Thr Gly Gln Cys Pro Cys Arg Glu Gly Phe Gly Gly Leu Met Cys Ser 
            500                 505                 510         


Ala Ala Ala Ile Arg Gln Cys Pro Asp Arg Thr Tyr Gly Asp Val Ala 
        515                 520                 525             


Thr Gly Cys Arg Ala Cys Asp Cys Asp Phe Arg Gly Thr Glu Gly Pro 
    530                 535                 540                 


Gly Cys Asp Lys Ala Ser Gly Arg Cys Leu Cys Arg Pro Gly Leu Thr 
545                 550                 555                 560 


Gly Pro Arg Cys Asp Gln Cys Gln Arg Gly Tyr Cys Asn Arg Tyr Pro 
                565                 570                 575     


Val Cys Val Ala Cys His Pro Cys Phe Gln Thr Tyr Asp Ala Asp Leu 
            580                 585                 590         


Arg Glu Gln Ala Leu Arg Phe Gly Arg Leu Arg Asn Ala Thr Ala Ser 
        595                 600                 605             


Leu Trp Ser Gly Pro Gly Leu Glu Asp Arg Gly Leu Ala Ser Arg Ile 
    610                 615                 620                 


Leu Asp Ala Lys Ser Lys Ile Glu Gln Ile Arg Ala Val Leu Ser Ser 
625                 630                 635                 640 


Pro Ala Val Thr Glu Gln Glu Val Ala Gln Val Ala Ser Ala Ile Leu 
                645                 650                 655     


Ser Leu Arg Arg Thr Leu Gln Gly Leu Gln Leu Asp Leu Pro Leu Glu 
            660                 665                 670         


Glu Glu Thr Leu Ser Leu Pro Arg Asp Leu Glu Ser Leu Asp Arg Ser 
        675                 680                 685             


Phe Asn Gly Leu Leu Thr Met Tyr Gln Arg Lys Arg Glu Gln Phe Glu 
    690                 695                 700                 


Lys Ile Ser Ser Ala Asp Pro Ser Gly Ala Phe Arg Met Leu Ser Thr 
705                 710                 715                 720 


Ala Tyr Glu Gln Ser Ala Gln Ala Ala Gln Gln Val Ser Asp Ser Ser 
                725                 730                 735     


Arg Leu Leu Asp Gln Leu Arg Asp Ser Arg Arg Glu Ala Glu Arg Leu 
            740                 745                 750         


Val Arg Gln Ala Gly Gly Gly Gly Gly Thr Gly Ser Pro Lys Leu Val 
        755                 760                 765             


Ala Leu Arg Leu Glu Met Ser Ser Leu Pro Asp Leu Thr Pro Thr Phe 
    770                 775                 780                 


Asn Lys Leu Cys Gly Asn Ser Arg Gln Met Ala Cys Thr Pro Ile Ser 
785                 790                 795                 800 


Cys Pro Gly Glu Leu Cys Pro Gln Asp Asn Gly Thr Ala Cys Gly Ser 
                805                 810                 815     


Arg Cys Arg Gly Val Leu Pro Arg Ala Gly Gly Ala Phe Leu Met Ala 
            820                 825                 830         


Gly Gln Val Ala Glu Gln Leu Arg Gly Phe Asn Ala Gln Leu Gln Arg 
        835                 840                 845             


Thr Arg Gln Met Ile Arg Ala Ala Glu Glu Ser Ala Ser Gln Ile Gln 
    850                 855                 860                 


Ser Ser Ala Gln Arg Leu Glu Thr Gln Val Ser Ala Ser Arg Ser Gln 
865                 870                 875                 880 


Met Glu Glu Asp Val Arg Arg Thr Arg Leu Leu Ile Gln Gln Val Arg 
                885                 890                 895     


Asp Phe Leu Thr Asp Pro Asp Thr Asp Ala Ala Thr Ile Gln Glu Val 
            900                 905                 910         


Ser Glu Ala Val Leu Ala Leu Trp Leu Pro Thr Asp Ser Ala Thr Val 
        915                 920                 925             


Leu Gln Lys Met Asn Glu Ile Gln Ala Ile Ala Ala Arg Leu Pro Asn 
    930                 935                 940                 


Val Asp Leu Val Leu Ser Gln Thr Lys Gln Asp Ile Ala Arg Ala Arg 
945                 950                 955                 960 


Arg Leu Gln Ala Glu Ala Glu Glu Ala Arg Ser Arg Ala His Ala Val 
                965                 970                 975     


Glu Gly Gln Val Glu Asp Val Val Gly Asn Leu Arg Gln Gly Thr Val 
            980                 985                 990         


Ala Leu Gln Glu Ala Gln Asp Thr  Met Gln Gly Thr Ser  Arg Ser Leu 
        995                 1000                 1005             


Arg Leu  Ile Gln Asp Arg Val  Ala Glu Val Gln Gln  Val Leu Arg 
    1010                 1015                 1020             


Pro Ala  Glu Lys Leu Val Thr  Ser Met Thr Lys Gln  Leu Gly Asp 
    1025                 1030                 1035             


Phe Trp  Thr Arg Met Glu Glu  Leu Arg His Gln Ala  Arg Gln Gln 
    1040                 1045                 1050             


Gly Ala  Glu Ala Val Gln Ala  Gln Gln Leu Ala Glu  Gly Ala Ser 
    1055                 1060                 1065             


Glu Gln  Ala Leu Ser Ala Gln  Glu Gly Phe Glu Arg  Ile Lys Gln 
    1070                 1075                 1080             


Lys Tyr  Ala Glu Leu Lys Asp  Arg Leu Gly Gln Ser  Ser Met Leu 
    1085                 1090                 1095             


Gly Glu  Gln Gly Ala Arg Ile  Gln Ser Val Lys Thr  Glu Ala Glu 
    1100                 1105                 1110             


Glu Leu  Phe Gly Glu Thr Met  Glu Met Met Asp Arg  Met Lys Asp 
    1115                 1120                 1125             


Met Glu  Leu Glu Leu Leu Arg  Gly Ser Gln Ala Ile  Met Leu Arg 
    1130                 1135                 1140             


Ser Ala  Asp Leu Thr Gly Leu  Glu Lys Arg Val Glu  Gln Ile Arg 
    1145                 1150                 1155             


Asp His  Ile Asn Gly Arg Val  Leu Tyr Tyr Ala Thr  Cys Lys 
    1160                 1165                 1170         


<210>  77
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210>  78
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Thr Ser Arg Thr Pro Leu Leu Val Thr Ala Cys Leu Tyr Tyr Ser 
1               5                   10                  15      


Tyr Cys Asn Ser Arg His Leu Gln Gln Gly Val Arg Lys Ser Lys Arg 
            20                  25                  30          


Pro Val Phe Ser His Cys Gln Val Pro Glu Thr Gln Lys Thr Asp Thr 
        35                  40                  45              


Arg His Leu Ser Gly Ala Arg Ala Gly Val Cys Pro Cys Cys His Pro 
    50                  55                  60                  


Asp Gly Leu Leu Ala Thr Met Arg Asp Leu Leu Gln Tyr Ile Ala Cys 
65                  70                  75                  80  


Phe Phe Ala Phe Phe Ser Ala Gly Phe Leu Ile Val Ala Thr Trp Thr 
                85                  90                  95      


Asp Cys Trp Met Val Asn Ala Asp Asp Ser Leu Glu Val Ser Thr Lys 
            100                 105                 110         


Cys Arg Gly Leu Trp Trp Glu Cys Val Thr Asn Ala Phe Asp Gly Ile 
        115                 120                 125             


Arg Thr Cys Asp Glu Tyr Asp Ser Ile Leu Ala Glu His Pro Leu Lys 
    130                 135                 140                 


Leu Val Val Thr Arg Ala Leu Met Ile Thr Ala Asp Ile Leu Ala Gly 
145                 150                 155                 160 


Phe Gly Phe Leu Thr Leu Leu Leu Gly Leu Asp Cys Val Lys Phe Leu 
                165                 170                 175     


Pro Asp Glu Pro Tyr Ile Lys Val Arg Ile Cys Phe Val Ala Gly Ala 
            180                 185                 190         


Thr Leu Leu Ile Ala Gly Thr Pro Gly Ile Ile Gly Ser Val Trp Tyr 
        195                 200                 205             


Ala Val Asp Val Tyr Val Glu Arg Ser Thr Leu Val Leu His Asn Ile 
    210                 215                 220                 


Phe Leu Gly Ile Gln Tyr Lys Phe Gly Trp Ser Cys Trp Leu Gly Met 
225                 230                 235                 240 


Ala Gly Ser Leu Gly Cys Phe Leu Ala Gly Ala Val Leu Thr Cys Cys 
                245                 250                 255     


Leu Tyr Leu Phe Lys Asp Val Gly Pro Glu Arg Asn Tyr Pro Tyr Ser 
            260                 265                 270         


Leu Arg Lys Ala Tyr Ser Ala Ala Gly Val Ser Met Ala Lys Ser Tyr 
        275                 280                 285             


Ser Ala Pro Arg Thr Glu Thr Ala Lys Met Tyr Ala Val Asp Thr Arg 
    290                 295                 300                 


Val 
305 


<210>  79
<211>  3333
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ala Ala Ala Ala Arg Pro Arg Gly Arg Ala Leu Gly Pro Val Leu 
1               5                   10                  15      


Pro Pro Thr Pro Leu Leu Leu Leu Val Leu Arg Val Leu Pro Ala Cys 
            20                  25                  30          


Gly Ala Thr Ala Arg Asp Pro Gly Ala Ala Ala Gly Leu Ser Leu His 
        35                  40                  45              


Pro Thr Tyr Phe Asn Leu Ala Glu Ala Ala Arg Ile Trp Ala Thr Ala 
    50                  55                  60                  


Thr Cys Gly Glu Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr 
                85                  90                  95      


Ile Gln Gly Gln Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys 
            100                 105                 110         


Ala His Pro Val Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln 
        115                 120                 125             


Ser Pro Pro Leu Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr 
    130                 135                 140                 


Leu Asp Leu Gly Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe 
145                 150                 155                 160 


Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp 
                165                 170                 175     


Phe Gly Ser Thr Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val 
            180                 185                 190         


Asp Cys Leu Lys Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg 
        195                 200                 205             


Asp Asp Asp Val Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu 
    210                 215                 220                 


Glu Asn Gly Glu Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala 
225                 230                 235                 240 


Lys Asn Phe Thr Phe Ser His Thr Leu Arg Glu Phe Thr Lys Ala Thr 
                245                 250                 255     


Asn Ile Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu 
            260                 265                 270         


Ile Ser Lys Ala Gln Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr 
        275                 280                 285             


Ser Ile Lys Asp Ile Ser Ile Gly Gly Gln Cys Val Cys Asn Gly His 
    290                 295                 300                 


Ala Glu Val Cys Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu 
305                 310                 315                 320 


Cys Gln His His Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly 
                325                 330                 335     


Tyr Asn Gln Arg Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu 
            340                 345                 350         


Cys Glu Ala Cys Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp 
        355                 360                 365             


Pro Asp Val Glu Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr 
    370                 375                 380                 


Ala Gly Gly Gly Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val 
385                 390                 395                 400 


Asn Cys Glu Gln Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His 
            420                 425                 430         


Ala Asp Gly Cys Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn 
        435                 440                 445             


Phe His Gly Asp Asn Cys Glu Lys Cys Ala Ile Gly Tyr Tyr Asn Phe 
    450                 455                 460                 


Pro Phe Cys Leu Arg Ile Pro Ile Phe Pro Val Ser Thr Pro Ser Ser 
465                 470                 475                 480 


Glu Asp Pro Val Ala Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu 
                485                 490                 495     


Gly Val Leu Pro Glu Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg 
            500                 505                 510         


Pro Gly Val Glu Gly Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr 
        515                 520                 525             


Ser Phe Pro Ile Cys Gln Ala Cys Trp Cys Ser Ala Leu Gly Ser Tyr 
    530                 535                 540                 


Gln Met Pro Cys Ser Ser Val Thr Gly Gln Cys Glu Cys Arg Pro Gly 
545                 550                 555                 560 


Val Thr Gly Gln Arg Cys Asp Arg Cys Leu Ser Gly Ala Tyr Asp Phe 
                565                 570                 575     


Pro His Cys Gln Gly Ser Ser Ser Ala Cys Asp Pro Ala Gly Thr Ile 
            580                 585                 590         


Asn Ser Asn Leu Gly Tyr Cys Gln Cys Lys Leu His Val Glu Gly Pro 
        595                 600                 605             


Thr Cys Ser Arg Cys Lys Leu Leu Tyr Trp Asn Leu Asp Lys Glu Asn 
    610                 615                 620                 


Pro Ser Gly Cys Ser Glu Cys Lys Cys His Lys Ala Gly Thr Val Ser 
625                 630                 635                 640 


Gly Thr Gly Glu Cys Arg Gln Gly Asp Gly Asp Cys His Cys Lys Ser 
                645                 650                 655     


His Val Gly Gly Asp Ser Cys Asp Thr Cys Glu Asp Gly Tyr Phe Ala 
            660                 665                 670         


Leu Glu Lys Ser Asn Tyr Phe Gly Cys Gln Gly Cys Gln Cys Asp Ile 
        675                 680                 685             


Gly Gly Ala Leu Ser Ser Met Cys Ser Gly Pro Ser Gly Val Cys Gln 
    690                 695                 700                 


Cys Arg Glu His Val Val Gly Lys Val Cys Gln Arg Pro Glu Asn Asn 
705                 710                 715                 720 


Tyr Tyr Phe Pro Asp Leu His His Met Lys Tyr Glu Ile Glu Asp Gly 
                725                 730                 735     


Ser Thr Pro Asn Gly Arg Asp Leu Arg Phe Gly Phe Asp Pro Leu Ala 
            740                 745                 750         


Phe Pro Glu Phe Ser Trp Arg Gly Tyr Ala Gln Met Thr Ser Val Gln 
        755                 760                 765             


Asn Asp Val Arg Ile Thr Leu Asn Val Gly Lys Ser Ser Gly Ser Leu 
    770                 775                 780                 


Phe Arg Val Ile Leu Arg Tyr Val Asn Pro Gly Thr Glu Ala Val Ser 
785                 790                 795                 800 


Gly His Ile Thr Ile Tyr Pro Ser Trp Gly Ala Ala Gln Ser Lys Glu 
                805                 810                 815     


Ile Ile Phe Leu Pro Ser Lys Glu Pro Ala Phe Val Thr Val Pro Gly 
            820                 825                 830         


Asn Gly Phe Ala Asp Pro Phe Ser Ile Thr Pro Gly Ile Trp Val Ala 
        835                 840                 845             


Cys Ile Lys Ala Glu Gly Val Leu Leu Asp Tyr Leu Val Leu Leu Pro 
    850                 855                 860                 


Arg Asp Tyr Tyr Glu Ala Ser Val Leu Gln Leu Pro Val Thr Glu Pro 
865                 870                 875                 880 


Cys Ala Tyr Ala Gly Pro Pro Gln Glu Asn Cys Leu Leu Tyr Gln His 
                885                 890                 895     


Leu Pro Val Thr Arg Phe Pro Cys Thr Leu Ala Cys Glu Ala Arg His 
            900                 905                 910         


Phe Leu Leu Asp Gly Glu Pro Arg Pro Val Ala Val Arg Gln Pro Thr 
        915                 920                 925             


Pro Ala His Pro Val Met Val Asp Leu Ser Gly Arg Glu Val Glu Leu 
    930                 935                 940                 


His Leu Arg Leu Arg Ile Pro Gln Val Gly His Tyr Val Val Val Val 
945                 950                 955                 960 


Glu Tyr Ser Thr Glu Ala Ala Gln Leu Phe Val Val Asp Val Asn Val 
                965                 970                 975     


Lys Ser Ser Gly Ser Val Leu Ala Gly Gln Val Asn Ile Tyr Ser Cys 
            980                 985                 990         


Asn Tyr Ser Val Leu Cys Arg Ser  Ala Val Ile Asp His  Met Ser Arg 
        995                 1000                 1005             


Ile Ala  Met Tyr Glu Leu Leu  Ala Asp Ala Asp Ile  Gln Leu Lys 
    1010                 1015                 1020             


Gly His  Met Ala Arg Phe Leu  Leu His Gln Val Cys  Ile Ile Pro 
    1025                 1030                 1035             


Ile Glu  Glu Phe Ser Ala Glu  Tyr Val Arg Pro Gln  Val His Cys 
    1040                 1045                 1050             


Ile Ala  Ser Tyr Gly Arg Phe  Val Asn Gln Ser Ala  Thr Cys Val 
    1055                 1060                 1065             


Ser Leu  Ala His Glu Thr Pro  Pro Thr Ala Leu Ile  Leu Asp Val 
    1070                 1075                 1080             


Leu Ser  Gly Arg Pro Phe Pro  His Leu Pro Gln Gln  Ser Ser Pro 
    1085                 1090                 1095             


Ser Val  Asp Val Leu Pro Gly  Val Thr Leu Lys Ala  Pro Gln Asn 
    1100                 1105                 1110             


Gln Val  Thr Leu Arg Gly Arg  Val Pro His Leu Gly  Arg Tyr Val 
    1115                 1120                 1125             


Phe Val  Ile His Phe Tyr Gln  Ala Ala His Pro Thr  Phe Pro Ala 
    1130                 1135                 1140             


Gln Val  Ser Val Asp Gly Gly  Trp Pro Arg Ala Gly  Ser Phe His 
    1145                 1150                 1155             


Ala Ser  Phe Cys Pro His Val  Leu Gly Cys Arg Asp  Gln Val Ile 
    1160                 1165                 1170             


Ala Glu  Gly Gln Ile Glu Phe  Asp Ile Ser Glu Pro  Glu Val Ala 
    1175                 1180                 1185             


Ala Thr  Val Lys Val Pro Glu  Gly Lys Ser Leu Val  Leu Val Arg 
    1190                 1195                 1200             


Val Leu  Val Val Pro Ala Glu  Asn Tyr Asp Tyr Gln  Ile Leu His 
    1205                 1210                 1215             


Lys Lys  Ser Met Asp Lys Ser  Leu Glu Phe Ile Thr  Asn Cys Gly 
    1220                 1225                 1230             


Lys Asn  Ser Phe Tyr Leu Asp  Pro Gln Thr Ala Ser  Arg Phe Cys 
    1235                 1240                 1245             


Lys Asn  Ser Ala Arg Ser Leu  Val Ala Phe Tyr His  Lys Gly Ala 
    1250                 1255                 1260             


Leu Pro  Cys Glu Cys His Pro  Thr Gly Ala Thr Gly  Pro His Cys 
    1265                 1270                 1275             


Ser Pro  Glu Gly Gly Gln Cys  Pro Cys Gln Pro Asn  Val Ile Gly 
    1280                 1285                 1290             


Arg Gln  Cys Thr Arg Cys Ala  Thr Gly His Tyr Gly  Phe Pro Arg 
    1295                 1300                 1305             


Cys Lys  Pro Cys Ser Cys Gly  Arg Arg Leu Cys Glu  Glu Met Thr 
    1310                 1315                 1320             


Gly Gln  Cys Arg Cys Pro Pro  Arg Thr Val Arg Pro  Gln Cys Glu 
    1325                 1330                 1335             


Val Cys  Glu Thr His Ser Phe  Ser Phe His Pro Met  Ala Gly Cys 
    1340                 1345                 1350             


Glu Gly  Cys Asn Cys Ser Arg  Arg Gly Thr Ile Glu  Ala Ala Met 
    1355                 1360                 1365             


Pro Glu  Cys Asp Arg Asp Ser  Gly Gln Cys Arg Cys  Lys Pro Arg 
    1370                 1375                 1380             


Ile Thr  Gly Arg Gln Cys Asp  Arg Cys Ala Ser Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Phe Pro  Glu Cys Val Pro Cys  Asn Cys Asn Arg Asp  Gly Thr Glu 
    1400                 1405                 1410             


Pro Gly  Val Cys Asp Pro Gly  Thr Gly Ala Cys Leu  Cys Lys Glu 
    1415                 1420                 1425             


Asn Val  Glu Gly Thr Glu Cys  Asn Val Cys Arg Glu  Gly Ser Phe 
    1430                 1435                 1440             


His Leu  Asp Pro Ala Asn Leu  Lys Gly Cys Thr Ser  Cys Phe Cys 
    1445                 1450                 1455             


Phe Gly  Val Asn Asn Gln Cys  His Ser Ser His Lys  Arg Arg Thr 
    1460                 1465                 1470             


Lys Phe  Val Asp Met Leu Gly  Trp His Leu Glu Thr  Ala Asp Arg 
    1475                 1480                 1485             


Val Asp  Ile Pro Val Ser Phe  Asn Pro Gly Ser Asn  Ser Met Val 
    1490                 1495                 1500             


Ala Asp  Leu Gln Glu Leu Pro  Ala Thr Ile His Ser  Ala Ser Trp 
    1505                 1510                 1515             


Val Ala  Pro Thr Ser Tyr Leu  Gly Asp Lys Val Ser  Ser Tyr Gly 
    1520                 1525                 1530             


Gly Tyr  Leu Thr Tyr Gln Ala  Lys Ser Phe Gly Leu  Pro Gly Asp 
    1535                 1540                 1545             


Met Val  Leu Leu Glu Lys Lys  Pro Asp Val Gln Leu  Thr Gly Gln 
    1550                 1555                 1560             


His Met  Ser Ile Ile Tyr Glu  Glu Thr Asn Thr Pro  Arg Pro Asp 
    1565                 1570                 1575             


Arg Leu  His His Gly Arg Val  His Val Val Glu Gly  Asn Phe Arg 
    1580                 1585                 1590             


His Ala  Ser Ser Arg Ala Pro  Val Ser Arg Glu Glu  Leu Met Thr 
    1595                 1600                 1605             


Val Leu  Ser Arg Leu Ala Asp  Val Arg Ile Gln Gly  Leu Tyr Phe 
    1610                 1615                 1620             


Thr Glu  Thr Gln Arg Leu Thr  Leu Ser Glu Val Gly  Leu Glu Glu 
    1625                 1630                 1635             


Ala Ser  Asp Thr Gly Ser Gly  Arg Ile Ala Leu Ala  Val Glu Ile 
    1640                 1645                 1650             


Cys Ala  Cys Pro Pro Ala Tyr  Ala Gly Asp Ser Cys  Gln Gly Cys 
    1655                 1660                 1665             


Ser Pro  Gly Tyr Tyr Arg Asp  His Lys Gly Leu Tyr  Thr Gly Arg 
    1670                 1675                 1680             


Cys Val  Pro Cys Asn Cys Asn  Gly His Ser Asn Gln  Cys Gln Asp 
    1685                 1690                 1695             


Gly Ser  Gly Ile Cys Val Asn  Cys Gln His Asn Thr  Ala Gly Glu 
    1700                 1705                 1710             


His Cys  Glu Arg Cys Gln Glu  Gly Tyr Tyr Gly Asn  Ala Val His 
    1715                 1720                 1725             


Gly Ser  Cys Arg Ala Cys Pro  Cys Pro His Thr Asn  Ser Phe Ala 
    1730                 1735                 1740             


Thr Gly  Cys Val Val Asn Gly  Gly Asp Val Arg Cys  Ser Cys Lys 
    1745                 1750                 1755             


Ala Gly  Tyr Thr Gly Thr Gln  Cys Glu Arg Cys Ala  Pro Gly Tyr 
    1760                 1765                 1770             


Phe Gly  Asn Pro Gln Lys Phe  Gly Gly Ser Cys Gln  Pro Cys Ser 
    1775                 1780                 1785             


Cys Asn  Ser Asn Gly Gln Leu  Gly Ser Cys His Pro  Leu Thr Gly 
    1790                 1795                 1800             


Asp Cys  Ile Asn Gln Glu Pro  Lys Asp Ser Ser Pro  Ala Glu Glu 
    1805                 1810                 1815             


Cys Asp  Asp Cys Asp Ser Cys  Val Met Thr Leu Leu  Asn Asp Leu 
    1820                 1825                 1830             


Ala Thr  Met Gly Glu Gln Leu  Arg Leu Val Lys Ser  Gln Leu Gln 
    1835                 1840                 1845             


Gly Leu  Ser Ala Ser Ala Gly  Leu Leu Glu Gln Met  Arg His Met 
    1850                 1855                 1860             


Glu Thr  Gln Ala Lys Asp Leu  Arg Asn Gln Leu Leu  Asn Tyr Arg 
    1865                 1870                 1875             


Ser Ala  Ile Ser Asn His Gly  Ser Lys Ile Glu Gly  Leu Glu Arg 
    1880                 1885                 1890             


Glu Leu  Thr Asp Leu Asn Gln  Glu Phe Glu Thr Leu  Gln Glu Lys 
    1895                 1900                 1905             


Ala Gln  Val Asn Ser Arg Lys  Ala Gln Thr Leu Asn  Asn Asn Val 
    1910                 1915                 1920             


Asn Arg  Ala Thr Gln Ser Ala  Lys Glu Leu Asp Val  Lys Ile Lys 
    1925                 1930                 1935             


Asn Val  Ile Arg Asn Val His  Ile Leu Leu Lys Gln  Ile Ser Gly 
    1940                 1945                 1950             


Thr Asp  Gly Glu Gly Asn Asn  Val Pro Ser Gly Asp  Phe Ser Arg 
    1955                 1960                 1965             


Glu Trp  Ala Glu Ala Gln Arg  Met Met Arg Glu Leu  Arg Asn Arg 
    1970                 1975                 1980             


Asn Phe  Gly Lys His Leu Arg  Glu Ala Glu Ala Asp  Lys Arg Glu 
    1985                 1990                 1995             


Ser Gln  Leu Leu Leu Asn Arg  Ile Arg Thr Trp Gln  Lys Thr His 
    2000                 2005                 2010             


Gln Gly  Glu Asn Asn Gly Leu  Ala Asn Ser Ile Arg  Asp Ser Leu 
    2015                 2020                 2025             


Asn Glu  Tyr Glu Ala Lys Leu  Ser Asp Leu Arg Ala  Arg Leu Gln 
    2030                 2035                 2040             


Glu Ala  Ala Ala Gln Ala Lys  Gln Ala Asn Gly Leu  Asn Gln Glu 
    2045                 2050                 2055             


Asn Glu  Arg Ala Leu Gly Ala  Ile Gln Arg Gln Val  Lys Glu Ile 
    2060                 2065                 2070             


Asn Ser  Leu Gln Ser Asp Phe  Thr Lys Tyr Leu Thr  Thr Ala Asp 
    2075                 2080                 2085             


Ser Ser  Leu Leu Gln Thr Asn  Ile Ala Leu Gln Leu  Met Glu Lys 
    2090                 2095                 2100             


Ser Gln  Lys Glu Tyr Glu Lys  Leu Ala Ala Ser Leu  Asn Glu Ala 
    2105                 2110                 2115             


Arg Gln  Glu Leu Ser Asp Lys  Val Arg Glu Leu Ser  Arg Ser Ala 
    2120                 2125                 2130             


Gly Lys  Thr Ser Leu Val Glu  Glu Ala Glu Lys His  Ala Arg Ser 
    2135                 2140                 2145             


Leu Gln  Glu Leu Ala Lys Gln  Leu Glu Glu Ile Lys  Arg Asn Ala 
    2150                 2155                 2160             


Ser Gly  Asp Glu Leu Val Arg  Cys Ala Val Asp Ala  Ala Thr Ala 
    2165                 2170                 2175             


Tyr Glu  Asn Ile Leu Asn Ala  Ile Lys Ala Ala Glu  Asp Ala Ala 
    2180                 2185                 2190             


Asn Arg  Ala Ala Ser Ala Ser  Glu Ser Ala Leu Gln  Thr Val Ile 
    2195                 2200                 2205             


Lys Glu  Asp Leu Pro Arg Lys  Ala Lys Thr Leu Ser  Ser Asn Ser 
    2210                 2215                 2220             


Asp Lys  Leu Leu Asn Glu Ala  Lys Met Thr Gln Lys  Lys Leu Lys 
    2225                 2230                 2235             


Gln Glu  Val Ser Pro Ala Leu  Asn Asn Leu Gln Gln  Thr Leu Asn 
    2240                 2245                 2250             


Ile Val  Thr Val Gln Lys Glu  Val Ile Asp Thr Asn  Leu Thr Thr 
    2255                 2260                 2265             


Leu Arg  Asp Gly Leu His Gly  Ile Gln Arg Gly Asp  Ile Asp Ala 
    2270                 2275                 2280             


Met Ile  Ser Ser Ala Lys Ser  Met Val Arg Lys Ala  Asn Asp Ile 
    2285                 2290                 2295             


Thr Asp  Glu Val Leu Asp Gly  Leu Asn Pro Ile Gln  Thr Asp Val 
    2300                 2305                 2310             


Glu Arg  Ile Lys Asp Thr Tyr  Gly Arg Thr Gln Asn  Glu Asp Phe 
    2315                 2320                 2325             


Lys Lys  Ala Leu Thr Asp Ala  Asp Asn Ser Val Asn  Lys Leu Thr 
    2330                 2335                 2340             


Asn Lys  Leu Pro Asp Leu Trp  Arg Lys Ile Glu Ser  Ile Asn Gln 
    2345                 2350                 2355             


Gln Leu  Leu Pro Leu Gly Asn  Ile Ser Asp Asn Met  Asp Arg Ile 
    2360                 2365                 2370             


Arg Glu  Leu Ile Gln Gln Ala  Arg Asp Ala Ala Ser  Lys Val Ala 
    2375                 2380                 2385             


Val Pro  Met Arg Phe Asn Gly  Lys Ser Gly Val Glu  Val Arg Leu 
    2390                 2395                 2400             


Pro Asn  Asp Leu Glu Asp Leu  Lys Gly Tyr Thr Ser  Leu Ser Leu 
    2405                 2410                 2415             


Phe Leu  Gln Arg Pro Asn Ser  Arg Glu Asn Gly Gly  Thr Glu Asn 
    2420                 2425                 2430             


Met Phe  Val Met Tyr Leu Gly  Asn Lys Asp Ala Ser  Arg Asp Tyr 
    2435                 2440                 2445             


Ile Gly  Met Ala Val Val Asp  Gly Gln Leu Thr Cys  Val Tyr Asn 
    2450                 2455                 2460             


Leu Gly  Asp Arg Glu Ala Glu  Leu Gln Val Asp Gln  Ile Leu Thr 
    2465                 2470                 2475             


Lys Ser  Glu Thr Lys Glu Ala  Val Met Asp Arg Val  Lys Phe Gln 
    2480                 2485                 2490             


Arg Ile  Tyr Gln Phe Ala Arg  Leu Asn Tyr Thr Lys  Gly Ala Thr 
    2495                 2500                 2505             


Ser Ser  Lys Pro Glu Thr Pro  Gly Val Tyr Asp Met  Asp Gly Arg 
    2510                 2515                 2520             


Asn Ser  Asn Thr Leu Leu Asn  Leu Asp Pro Glu Asn  Val Val Phe 
    2525                 2530                 2535             


Tyr Val  Gly Gly Tyr Pro Pro  Asp Phe Lys Leu Pro  Ser Arg Leu 
    2540                 2545                 2550             


Ser Phe  Pro Pro Tyr Lys Gly  Cys Ile Glu Leu Asp  Asp Leu Asn 
    2555                 2560                 2565             


Glu Asn  Val Leu Ser Leu Tyr  Asn Phe Lys Lys Thr  Phe Asn Leu 
    2570                 2575                 2580             


Asn Thr  Thr Glu Val Glu Pro  Cys Arg Arg Arg Lys  Glu Glu Ser 
    2585                 2590                 2595             


Asp Lys  Asn Tyr Phe Glu Gly  Thr Gly Tyr Ala Arg  Val Pro Thr 
    2600                 2605                 2610             


Gln Pro  His Ala Pro Ile Pro  Thr Phe Gly Gln Thr  Ile Gln Thr 
    2615                 2620                 2625             


Thr Val  Asp Arg Gly Leu Leu  Phe Phe Ala Glu Asn  Gly Asp Arg 
    2630                 2635                 2640             


Phe Ile  Ser Leu Asn Ile Glu  Asp Gly Lys Leu Met  Val Arg Tyr 
    2645                 2650                 2655             


Lys Leu  Asn Ser Glu Leu Pro  Lys Glu Arg Gly Val  Gly Asp Ala 
    2660                 2665                 2670             


Ile Asn  Asn Gly Arg Asp His  Ser Ile Gln Ile Lys  Ile Gly Lys 
    2675                 2680                 2685             


Leu Gln  Lys Arg Met Trp Ile  Asn Val Asp Val Gln  Asn Thr Ile 
    2690                 2695                 2700             


Ile Asp  Gly Glu Val Phe Asp  Phe Ser Thr Tyr Tyr  Leu Gly Gly 
    2705                 2710                 2715             


Ile Pro  Ile Ala Ile Arg Glu  Arg Phe Asn Ile Ser  Thr Pro Ala 
    2720                 2725                 2730             


Phe Arg  Gly Cys Met Lys Asn  Leu Lys Lys Thr Ser  Gly Val Val 
    2735                 2740                 2745             


Arg Leu  Asn Asp Thr Val Gly  Val Thr Lys Lys Cys  Ser Glu Asp 
    2750                 2755                 2760             


Trp Lys  Leu Val Arg Ser Ala  Ser Phe Ser Arg Gly  Gly Gln Leu 
    2765                 2770                 2775             


Ser Phe  Thr Asp Leu Gly Leu  Pro Pro Thr Asp His  Leu Gln Ala 
    2780                 2785                 2790             


Ser Phe  Gly Phe Gln Thr Phe  Gln Pro Ser Gly Ile  Leu Leu Asp 
    2795                 2800                 2805             


His Gln  Thr Trp Thr Arg Asn  Leu Gln Val Thr Leu  Glu Asp Gly 
    2810                 2815                 2820             


Tyr Ile  Glu Leu Ser Thr Ser  Asp Ser Gly Ser Pro  Ile Phe Lys 
    2825                 2830                 2835             


Ser Pro  Gln Thr Tyr Met Asp  Gly Leu Leu His Tyr  Val Ser Val 
    2840                 2845                 2850             


Ile Ser  Asp Asn Ser Gly Leu  Arg Leu Leu Ile Asp  Asp Gln Leu 
    2855                 2860                 2865             


Leu Arg  Asn Ser Lys Arg Leu  Lys His Ile Ser Ser  Ser Arg Gln 
    2870                 2875                 2880             


Ser Leu  Arg Leu Gly Gly Ser  Asn Phe Glu Gly Cys  Ile Ser Asn 
    2885                 2890                 2895             


Val Phe  Val Gln Arg Leu Ser  Leu Ser Pro Glu Val  Leu Asp Leu 
    2900                 2905                 2910             


Thr Ser  Asn Ser Leu Lys Arg  Asp Val Ser Leu Gly  Gly Cys Ser 
    2915                 2920                 2925             


Leu Asn  Lys Pro Pro Phe Leu  Met Leu Leu Lys Gly  Ser Thr Arg 
    2930                 2935                 2940             


Phe Asn  Lys Thr Lys Thr Phe  Arg Ile Asn Gln Leu  Leu Gln Asp 
    2945                 2950                 2955             


Thr Pro  Val Ala Ser Pro Arg  Ser Val Lys Val Trp  Gln Asp Ala 
    2960                 2965                 2970             


Cys Ser  Pro Leu Pro Lys Thr  Gln Ala Asn His Gly  Ala Leu Gln 
    2975                 2980                 2985             


Phe Gly  Asp Ile Pro Thr Ser  His Leu Leu Phe Lys  Leu Pro Gln 
    2990                 2995                 3000             


Glu Leu  Leu Lys Pro Arg Ser  Gln Phe Ala Val Asp  Met Gln Thr 
    3005                 3010                 3015             


Thr Ser  Ser Arg Gly Leu Val  Phe His Thr Gly Thr  Lys Asn Ser 
    3020                 3025                 3030             


Phe Met  Ala Leu Tyr Leu Ser  Lys Gly Arg Leu Val  Phe Ala Leu 
    3035                 3040                 3045             


Gly Thr  Asp Gly Lys Lys Leu  Arg Ile Lys Ser Lys  Glu Lys Cys 
    3050                 3055                 3060             


Asn Asp  Gly Lys Trp His Thr  Val Val Phe Gly His  Asp Gly Glu 
    3065                 3070                 3075             


Lys Gly  Arg Leu Val Val Asp  Gly Leu Arg Ala Arg  Glu Gly Ser 
    3080                 3085                 3090             


Leu Pro  Gly Asn Ser Thr Ile  Ser Ile Arg Ala Pro  Val Tyr Leu 
    3095                 3100                 3105             


Gly Ser  Pro Pro Ser Gly Lys  Pro Lys Ser Leu Pro  Thr Asn Ser 
    3110                 3115                 3120             


Phe Val  Gly Cys Leu Lys Asn  Phe Gln Leu Asp Ser  Lys Pro Leu 
    3125                 3130                 3135             


Tyr Thr  Pro Ser Ser Ser Phe  Gly Val Ser Ser Cys  Leu Gly Gly 
    3140                 3145                 3150             


Pro Leu  Glu Lys Gly Ile Tyr  Phe Ser Glu Glu Gly  Gly His Val 
    3155                 3160                 3165             


Val Leu  Ala His Ser Val Leu  Leu Gly Pro Glu Phe  Lys Leu Val 
    3170                 3175                 3180             


Phe Ser  Ile Arg Pro Arg Ser  Leu Thr Gly Ile Leu  Ile His Ile 
    3185                 3190                 3195             


Gly Ser  Gln Pro Gly Lys His  Leu Cys Val Tyr Leu  Glu Ala Gly 
    3200                 3205                 3210             


Lys Val  Thr Ala Ser Met Asp  Ser Gly Ala Gly Gly  Thr Ser Thr 
    3215                 3220                 3225             


Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp Gly Gln  Trp His Ser 
    3230                 3235                 3240             


Val Ala  Val Thr Ile Lys Gln  His Ile Leu His Leu  Glu Leu Asp 
    3245                 3250                 3255             


Thr Asp  Ser Ser Tyr Thr Ala  Gly Gln Ile Pro Phe  Pro Pro Ala 
    3260                 3265                 3270             


Ser Thr  Gln Glu Pro Leu His  Leu Gly Gly Ala Pro  Ala Asn Leu 
    3275                 3280                 3285             


Thr Thr  Leu Arg Ile Pro Val  Trp Lys Ser Phe Phe  Gly Cys Leu 
    3290                 3295                 3300             


Arg Asn  Ile His Val Asn His  Ile Pro Val Pro Val  Thr Glu Ala 
    3305                 3310                 3315             


Leu Glu  Val Gln Gly Pro Val  Ser Leu Asn Gly Cys  Pro Asp Gln 
    3320                 3325                 3330             


<210>  80
<211>  3277
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ala Ala Ala Ala Arg Pro Arg Gly Arg Ala Leu Gly Pro Val Leu 
1               5                   10                  15      


Pro Pro Thr Pro Leu Leu Leu Leu Val Leu Arg Val Leu Pro Ala Cys 
            20                  25                  30          


Gly Ala Thr Ala Arg Asp Pro Gly Ala Ala Ala Gly Leu Ser Leu His 
        35                  40                  45              


Pro Thr Tyr Phe Asn Leu Ala Glu Ala Ala Arg Ile Trp Ala Thr Ala 
    50                  55                  60                  


Thr Cys Gly Glu Arg Gly Pro Gly Glu Gly Arg Pro Gln Pro Glu Leu 
65                  70                  75                  80  


Tyr Cys Lys Leu Val Gly Gly Pro Thr Ala Pro Gly Ser Gly His Thr 
                85                  90                  95      


Ile Gln Gly Gln Phe Cys Asp Tyr Cys Asn Ser Glu Asp Pro Arg Lys 
            100                 105                 110         


Ala His Pro Val Thr Asn Ala Ile Asp Gly Ser Glu Arg Trp Trp Gln 
        115                 120                 125             


Ser Pro Pro Leu Ser Ser Gly Thr Gln Tyr Asn Arg Val Asn Leu Thr 
    130                 135                 140                 


Leu Asp Leu Gly Gln Leu Phe His Val Ala Tyr Ile Leu Ile Lys Phe 
145                 150                 155                 160 


Ala Asn Ser Pro Arg Pro Asp Leu Trp Val Leu Glu Arg Ser Val Asp 
                165                 170                 175     


Phe Gly Ser Thr Tyr Ser Pro Trp Gln Tyr Phe Ala His Ser Lys Val 
            180                 185                 190         


Asp Cys Leu Lys Glu Phe Gly Arg Glu Ala Asn Met Ala Val Thr Arg 
        195                 200                 205             


Asp Asp Asp Val Leu Cys Val Thr Glu Tyr Ser Arg Ile Val Pro Leu 
    210                 215                 220                 


Glu Asn Gly Glu Val Val Val Ser Leu Ile Asn Gly Arg Pro Gly Ala 
225                 230                 235                 240 


Lys Asn Phe Thr Phe Ser His Thr Leu Arg Glu Phe Thr Lys Ala Thr 
                245                 250                 255     


Asn Ile Arg Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu 
            260                 265                 270         


Ile Ser Lys Ala Gln Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr 
        275                 280                 285             


Ser Ile Lys Asp Ile Ser Ile Gly Gly Gln Cys Val Cys Asn Gly His 
    290                 295                 300                 


Ala Glu Val Cys Asn Ile Asn Asn Pro Glu Lys Leu Phe Arg Cys Glu 
305                 310                 315                 320 


Cys Gln His His Thr Cys Gly Glu Thr Cys Asp Arg Cys Cys Thr Gly 
                325                 330                 335     


Tyr Asn Gln Arg Arg Trp Arg Pro Ala Ala Trp Glu Gln Ser His Glu 
            340                 345                 350         


Cys Glu Ala Cys Asn Cys His Gly His Ala Ser Asn Cys Tyr Tyr Asp 
        355                 360                 365             


Pro Asp Val Glu Arg Gln Gln Ala Ser Leu Asn Thr Gln Gly Ile Tyr 
    370                 375                 380                 


Ala Gly Gly Gly Val Cys Ile Asn Cys Gln His Asn Thr Ala Gly Val 
385                 390                 395                 400 


Asn Cys Glu Gln Cys Ala Lys Gly Tyr Tyr Arg Pro Tyr Gly Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asp Gly Cys Ile Pro Cys Ser Cys Asp Pro Glu His 
            420                 425                 430         


Ala Asp Gly Cys Glu Gln Gly Ser Gly Arg Cys His Cys Lys Pro Asn 
        435                 440                 445             


Phe His Gly Asp Asn Cys Glu Lys Cys Ala Ile Gly Tyr Tyr Asn Phe 
    450                 455                 460                 


Pro Phe Cys Leu Arg Ile Pro Ile Phe Pro Val Ser Thr Pro Ser Ser 
465                 470                 475                 480 


Glu Asp Pro Val Ala Gly Asp Ile Lys Gly Cys Asp Cys Asn Leu Glu 
                485                 490                 495     


Gly Val Leu Pro Glu Ile Cys Asp Ala His Gly Arg Cys Leu Cys Arg 
            500                 505                 510         


Pro Gly Val Glu Gly Pro Arg Cys Asp Thr Cys Arg Ser Gly Phe Tyr 
        515                 520                 525             


Ser Phe Pro Ile Cys Gln Ala Cys Trp Cys Ser Ala Leu Gly Ser Tyr 
    530                 535                 540                 


Gln Met Pro Cys Ser Ser Val Thr Gly Gln Cys Glu Cys Arg Pro Gly 
545                 550                 555                 560 


Val Thr Gly Gln Arg Cys Asp Arg Cys Leu Ser Gly Ala Tyr Asp Phe 
                565                 570                 575     


Pro His Cys Gln Gly Ser Ser Ser Ala Cys Asp Pro Ala Gly Thr Ile 
            580                 585                 590         


Asn Ser Asn Leu Gly Tyr Cys Gln Cys Lys Leu His Val Glu Gly Pro 
        595                 600                 605             


Thr Cys Ser Arg Cys Lys Leu Leu Tyr Trp Asn Leu Asp Lys Glu Asn 
    610                 615                 620                 


Pro Ser Gly Cys Ser Glu Cys Lys Cys His Lys Ala Gly Thr Val Ser 
625                 630                 635                 640 


Gly Thr Gly Glu Cys Arg Gln Gly Asp Gly Asp Cys His Cys Lys Ser 
                645                 650                 655     


His Val Gly Gly Asp Ser Cys Asp Thr Cys Glu Asp Gly Tyr Phe Ala 
            660                 665                 670         


Leu Glu Lys Ser Asn Tyr Phe Gly Cys Gln Gly Cys Gln Cys Asp Ile 
        675                 680                 685             


Gly Gly Ala Leu Ser Ser Met Cys Ser Gly Pro Ser Gly Val Cys Gln 
    690                 695                 700                 


Cys Arg Glu His Val Val Gly Lys Val Cys Gln Arg Pro Glu Asn Asn 
705                 710                 715                 720 


Tyr Tyr Phe Pro Asp Leu His His Met Lys Tyr Glu Ile Glu Asp Gly 
                725                 730                 735     


Ser Thr Pro Asn Gly Arg Asp Leu Arg Phe Gly Phe Asp Pro Leu Ala 
            740                 745                 750         


Phe Pro Glu Phe Ser Trp Arg Gly Tyr Ala Gln Met Thr Ser Val Gln 
        755                 760                 765             


Asn Asp Val Arg Ile Thr Leu Asn Val Gly Lys Ser Ser Gly Ser Leu 
    770                 775                 780                 


Phe Arg Val Ile Leu Arg Tyr Val Asn Pro Gly Thr Glu Ala Val Ser 
785                 790                 795                 800 


Gly His Ile Thr Ile Tyr Pro Ser Trp Gly Ala Ala Gln Ser Lys Glu 
                805                 810                 815     


Ile Ile Phe Leu Pro Ser Lys Glu Pro Ala Phe Val Thr Val Pro Gly 
            820                 825                 830         


Asn Gly Phe Ala Asp Pro Phe Ser Ile Thr Pro Gly Ile Trp Val Ala 
        835                 840                 845             


Cys Ile Lys Ala Glu Gly Val Leu Leu Asp Tyr Leu Val Leu Leu Pro 
    850                 855                 860                 


Arg Asp Tyr Tyr Glu Ala Ser Val Leu Gln Leu Pro Val Thr Glu Pro 
865                 870                 875                 880 


Cys Ala Tyr Ala Gly Pro Pro Gln Glu Asn Cys Leu Leu Tyr Gln His 
                885                 890                 895     


Leu Pro Val Thr Arg Phe Pro Cys Thr Leu Ala Cys Glu Ala Arg His 
            900                 905                 910         


Phe Leu Leu Asp Gly Glu Pro Arg Pro Val Ala Val Arg Gln Pro Thr 
        915                 920                 925             


Pro Ala His Pro Val Met Val Asp Leu Ser Gly Arg Glu Val Glu Leu 
    930                 935                 940                 


His Leu Arg Leu Arg Ile Pro Gln Val Gly His Tyr Val Val Val Val 
945                 950                 955                 960 


Glu Tyr Ser Thr Glu Ala Ala Gln Leu Phe Val Val Asp Val Asn Val 
                965                 970                 975     


Lys Ser Ser Gly Ser Val Leu Ala Gly Gln Val Asn Ile Tyr Ser Cys 
            980                 985                 990         


Asn Tyr Ser Val Leu Cys Arg Ser  Ala Val Ile Asp His  Met Ser Arg 
        995                 1000                 1005             


Ile Ala  Met Tyr Glu Leu Leu  Ala Asp Ala Asp Ile  Gln Leu Lys 
    1010                 1015                 1020             


Gly His  Met Ala Arg Phe Leu  Leu His Gln Val Cys  Ile Ile Pro 
    1025                 1030                 1035             


Ile Glu  Glu Phe Ser Ala Glu  Tyr Val Arg Pro Gln  Val His Cys 
    1040                 1045                 1050             


Ile Ala  Ser Tyr Gly Arg Phe  Val Asn Gln Ser Ala  Thr Cys Val 
    1055                 1060                 1065             


Ser Leu  Ala His Glu Thr Pro  Pro Thr Ala Leu Ile  Leu Asp Val 
    1070                 1075                 1080             


Leu Ser  Gly Arg Pro Phe Pro  His Leu Pro Gln Gln  Ser Ser Pro 
    1085                 1090                 1095             


Ser Val  Asp Val Leu Pro Gly  Val Thr Leu Lys Ala  Pro Gln Asn 
    1100                 1105                 1110             


Gln Val  Thr Leu Arg Gly Arg  Val Pro His Leu Gly  Arg Tyr Val 
    1115                 1120                 1125             


Phe Val  Ile His Phe Tyr Gln  Ala Ala His Pro Thr  Phe Pro Ala 
    1130                 1135                 1140             


Gln Val  Ser Val Asp Gly Gly  Trp Pro Arg Ala Gly  Ser Phe His 
    1145                 1150                 1155             


Ala Ser  Phe Cys Pro His Val  Leu Gly Cys Arg Asp  Gln Val Ile 
    1160                 1165                 1170             


Ala Glu  Gly Gln Ile Glu Phe  Asp Ile Ser Glu Pro  Glu Val Ala 
    1175                 1180                 1185             


Ala Thr  Val Lys Val Pro Glu  Gly Lys Ser Leu Val  Leu Val Arg 
    1190                 1195                 1200             


Val Leu  Val Val Pro Ala Glu  Asn Tyr Asp Tyr Gln  Ile Leu His 
    1205                 1210                 1215             


Lys Lys  Ser Met Asp Lys Ser  Leu Glu Phe Ile Thr  Asn Cys Gly 
    1220                 1225                 1230             


Lys Asn  Ser Phe Tyr Leu Asp  Pro Gln Thr Ala Ser  Arg Phe Cys 
    1235                 1240                 1245             


Lys Asn  Ser Ala Arg Ser Leu  Val Ala Phe Tyr His  Lys Gly Ala 
    1250                 1255                 1260             


Leu Pro  Cys Glu Cys His Pro  Thr Gly Ala Thr Gly  Pro His Cys 
    1265                 1270                 1275             


Ser Pro  Glu Gly Gly Gln Cys  Pro Cys Gln Pro Asn  Val Ile Gly 
    1280                 1285                 1290             


Arg Gln  Cys Thr Arg Cys Ala  Thr Gly His Tyr Gly  Phe Pro Arg 
    1295                 1300                 1305             


Cys Lys  Pro Cys Ser Cys Gly  Arg Arg Leu Cys Glu  Glu Met Thr 
    1310                 1315                 1320             


Gly Gln  Cys Arg Cys Pro Pro  Arg Thr Val Arg Pro  Gln Cys Glu 
    1325                 1330                 1335             


Val Cys  Glu Thr His Ser Phe  Ser Phe His Pro Met  Ala Gly Cys 
    1340                 1345                 1350             


Glu Gly  Cys Asn Cys Ser Arg  Arg Gly Thr Ile Glu  Ala Ala Met 
    1355                 1360                 1365             


Pro Glu  Cys Asp Arg Asp Ser  Gly Gln Cys Arg Cys  Lys Pro Arg 
    1370                 1375                 1380             


Ile Thr  Gly Arg Gln Cys Asp  Arg Cys Ala Ser Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Phe Pro  Glu Cys Val Pro Cys  Asn Cys Asn Arg Asp  Gly Thr Glu 
    1400                 1405                 1410             


Pro Gly  Val Cys Asp Pro Gly  Thr Gly Ala Cys Leu  Cys Lys Glu 
    1415                 1420                 1425             


Asn Val  Glu Gly Thr Glu Cys  Asn Val Cys Arg Glu  Gly Ser Phe 
    1430                 1435                 1440             


His Leu  Asp Pro Ala Asn Leu  Lys Gly Cys Thr Ser  Cys Phe Cys 
    1445                 1450                 1455             


Phe Gly  Val Asn Asn Gln Cys  His Ser Ser His Lys  Arg Arg Thr 
    1460                 1465                 1470             


Lys Phe  Val Asp Met Leu Gly  Trp His Leu Glu Thr  Ala Asp Arg 
    1475                 1480                 1485             


Val Asp  Ile Pro Val Ser Phe  Asn Pro Gly Ser Asn  Ser Met Val 
    1490                 1495                 1500             


Ala Asp  Leu Gln Glu Leu Pro  Ala Thr Ile His Ser  Ala Ser Trp 
    1505                 1510                 1515             


Val Ala  Pro Thr Ser Tyr Leu  Gly Asp Lys Val Ser  Ser Tyr Gly 
    1520                 1525                 1530             


Gly Tyr  Leu Thr Tyr Gln Ala  Lys Ser Phe Gly Leu  Pro Gly Asp 
    1535                 1540                 1545             


Met Val  Leu Leu Glu Lys Lys  Pro Asp Val Gln Leu  Thr Gly Gln 
    1550                 1555                 1560             


His Met  Ser Ile Ile Tyr Glu  Glu Thr Asn Thr Pro  Arg Pro Asp 
    1565                 1570                 1575             


Arg Leu  His His Gly Arg Val  His Val Val Glu Gly  Asn Phe Arg 
    1580                 1585                 1590             


His Ala  Ser Ser Arg Ala Pro  Val Ser Arg Glu Glu  Leu Met Thr 
    1595                 1600                 1605             


Val Leu  Ser Arg Leu Ala Asp  Val Arg Ile Gln Gly  Leu Tyr Phe 
    1610                 1615                 1620             


Thr Glu  Thr Gln Arg Leu Thr  Leu Ser Glu Val Gly  Leu Glu Glu 
    1625                 1630                 1635             


Ala Ser  Asp Thr Gly Ser Gly  Arg Ile Ala Leu Ala  Val Glu Ile 
    1640                 1645                 1650             


Cys Ala  Cys Pro Pro Ala Tyr  Ala Gly Asp Ser Cys  Gln Gly Cys 
    1655                 1660                 1665             


Ser Pro  Gly Tyr Tyr Arg Asp  His Lys Gly Leu Tyr  Thr Gly Arg 
    1670                 1675                 1680             


Cys Val  Pro Cys Asn Cys Asn  Gly His Ser Asn Gln  Cys Gln Asp 
    1685                 1690                 1695             


Gly Ser  Gly Ile Cys Val Asn  Cys Gln His Asn Thr  Ala Gly Glu 
    1700                 1705                 1710             


His Cys  Glu Arg Cys Gln Glu  Gly Tyr Tyr Gly Asn  Ala Val His 
    1715                 1720                 1725             


Gly Ser  Cys Arg Ala Cys Pro  Cys Pro His Thr Asn  Ser Phe Ala 
    1730                 1735                 1740             


Thr Gly  Cys Val Val Asn Gly  Gly Asp Val Arg Cys  Ser Cys Lys 
    1745                 1750                 1755             


Ala Gly  Tyr Thr Gly Thr Gln  Cys Glu Arg Cys Ala  Pro Gly Tyr 
    1760                 1765                 1770             


Phe Gly  Asn Pro Gln Lys Phe  Gly Gly Ser Cys Gln  Pro Cys Ser 
    1775                 1780                 1785             


Cys Asn  Ser Asn Gly Gln Leu  Gly Ser Cys His Pro  Leu Thr Gly 
    1790                 1795                 1800             


Asp Cys  Ile Asn Gln Glu Pro  Lys Asp Ser Ser Pro  Ala Glu Glu 
    1805                 1810                 1815             


Cys Asp  Asp Cys Asp Ser Cys  Val Met Thr Leu Leu  Asn Asp Leu 
    1820                 1825                 1830             


Ala Thr  Met Gly Glu Gln Leu  Arg Leu Val Lys Ser  Gln Leu Gln 
    1835                 1840                 1845             


Gly Leu  Ser Ala Ser Ala Gly  Leu Leu Glu Gln Met  Arg His Met 
    1850                 1855                 1860             


Glu Thr  Gln Ala Lys Asp Leu  Arg Asn Gln Leu Leu  Asn Tyr Arg 
    1865                 1870                 1875             


Ser Ala  Ile Ser Asn His Gly  Ser Lys Ile Glu Gly  Leu Glu Arg 
    1880                 1885                 1890             


Glu Leu  Thr Asp Leu Asn Gln  Glu Phe Glu Thr Leu  Gln Glu Lys 
    1895                 1900                 1905             


Ala Gln  Val Asn Ser Arg Lys  Ala Gln Thr Leu Asn  Asn Asn Val 
    1910                 1915                 1920             


Asn Arg  Ala Thr Gln Ser Ala  Lys Glu Leu Asp Val  Lys Ile Lys 
    1925                 1930                 1935             


Asn Val  Ile Arg Asn Val His  Met Leu Asn Arg Ile  Arg Thr Trp 
    1940                 1945                 1950             


Gln Lys  Thr His Gln Gly Glu  Asn Asn Gly Leu Ala  Asn Ser Ile 
    1955                 1960                 1965             


Arg Asp  Ser Leu Asn Glu Tyr  Glu Ala Lys Leu Ser  Asp Leu Arg 
    1970                 1975                 1980             


Ala Arg  Leu Gln Glu Ala Ala  Ala Gln Ala Lys Gln  Ala Asn Gly 
    1985                 1990                 1995             


Leu Asn  Gln Glu Asn Glu Arg  Ala Leu Gly Ala Ile  Gln Arg Gln 
    2000                 2005                 2010             


Val Lys  Glu Ile Asn Ser Leu  Gln Ser Asp Phe Thr  Lys Tyr Leu 
    2015                 2020                 2025             


Thr Thr  Ala Asp Ser Ser Leu  Leu Gln Thr Asn Ile  Ala Leu Gln 
    2030                 2035                 2040             


Leu Met  Glu Lys Ser Gln Lys  Glu Tyr Glu Lys Leu  Ala Ala Ser 
    2045                 2050                 2055             


Leu Asn  Glu Ala Arg Gln Glu  Leu Ser Asp Lys Val  Arg Glu Leu 
    2060                 2065                 2070             


Ser Arg  Ser Ala Gly Lys Thr  Ser Leu Val Glu Glu  Ala Glu Lys 
    2075                 2080                 2085             


His Ala  Arg Ser Leu Gln Glu  Leu Ala Lys Gln Leu  Glu Glu Ile 
    2090                 2095                 2100             


Lys Arg  Asn Ala Ser Gly Asp  Glu Leu Val Arg Cys  Ala Val Asp 
    2105                 2110                 2115             


Ala Ala  Thr Ala Tyr Glu Asn  Ile Leu Asn Ala Ile  Lys Ala Ala 
    2120                 2125                 2130             


Glu Asp  Ala Ala Asn Arg Ala  Ala Ser Ala Ser Glu  Ser Ala Leu 
    2135                 2140                 2145             


Gln Thr  Val Ile Lys Glu Asp  Leu Pro Arg Lys Ala  Lys Thr Leu 
    2150                 2155                 2160             


Ser Ser  Asn Ser Asp Lys Leu  Leu Asn Glu Ala Lys  Met Thr Gln 
    2165                 2170                 2175             


Lys Lys  Leu Lys Gln Glu Val  Ser Pro Ala Leu Asn  Asn Leu Gln 
    2180                 2185                 2190             


Gln Thr  Leu Asn Ile Val Thr  Val Gln Lys Glu Val  Ile Asp Thr 
    2195                 2200                 2205             


Asn Leu  Thr Thr Leu Arg Asp  Gly Leu His Gly Ile  Gln Arg Gly 
    2210                 2215                 2220             


Asp Ile  Asp Ala Met Ile Ser  Ser Ala Lys Ser Met  Val Arg Lys 
    2225                 2230                 2235             


Ala Asn  Asp Ile Thr Asp Glu  Val Leu Asp Gly Leu  Asn Pro Ile 
    2240                 2245                 2250             


Gln Thr  Asp Val Glu Arg Ile  Lys Asp Thr Tyr Gly  Arg Thr Gln 
    2255                 2260                 2265             


Asn Glu  Asp Phe Lys Lys Ala  Leu Thr Asp Ala Asp  Asn Ser Val 
    2270                 2275                 2280             


Asn Lys  Leu Thr Asn Lys Leu  Pro Asp Leu Trp Arg  Lys Ile Glu 
    2285                 2290                 2295             


Ser Ile  Asn Gln Gln Leu Leu  Pro Leu Gly Asn Ile  Ser Asp Asn 
    2300                 2305                 2310             


Met Asp  Arg Ile Arg Glu Leu  Ile Gln Gln Ala Arg  Asp Ala Ala 
    2315                 2320                 2325             


Ser Lys  Val Ala Val Pro Met  Arg Phe Asn Gly Lys  Ser Gly Val 
    2330                 2335                 2340             


Glu Val  Arg Leu Pro Asn Asp  Leu Glu Asp Leu Lys  Gly Tyr Thr 
    2345                 2350                 2355             


Ser Leu  Ser Leu Phe Leu Gln  Arg Pro Asn Ser Arg  Glu Asn Gly 
    2360                 2365                 2370             


Gly Thr  Glu Asn Met Phe Val  Met Tyr Leu Gly Asn  Lys Asp Ala 
    2375                 2380                 2385             


Ser Arg  Asp Tyr Ile Gly Met  Ala Val Val Asp Gly  Gln Leu Thr 
    2390                 2395                 2400             


Cys Val  Tyr Asn Leu Gly Asp  Arg Glu Ala Glu Leu  Gln Val Asp 
    2405                 2410                 2415             


Gln Ile  Leu Thr Lys Ser Glu  Thr Lys Glu Ala Val  Met Asp Arg 
    2420                 2425                 2430             


Val Lys  Phe Gln Arg Ile Tyr  Gln Phe Ala Arg Leu  Asn Tyr Thr 
    2435                 2440                 2445             


Lys Gly  Ala Thr Ser Ser Lys  Pro Glu Thr Pro Gly  Val Tyr Asp 
    2450                 2455                 2460             


Met Asp  Gly Arg Asn Ser Asn  Thr Leu Leu Asn Leu  Asp Pro Glu 
    2465                 2470                 2475             


Asn Val  Val Phe Tyr Val Gly  Gly Tyr Pro Pro Asp  Phe Lys Leu 
    2480                 2485                 2490             


Pro Ser  Arg Leu Ser Phe Pro  Pro Tyr Lys Gly Cys  Ile Glu Leu 
    2495                 2500                 2505             


Asp Asp  Leu Asn Glu Asn Val  Leu Ser Leu Tyr Asn  Phe Lys Lys 
    2510                 2515                 2520             


Thr Phe  Asn Leu Asn Thr Thr  Glu Val Glu Pro Cys  Arg Arg Arg 
    2525                 2530                 2535             


Lys Glu  Glu Ser Asp Lys Asn  Tyr Phe Glu Gly Thr  Gly Tyr Ala 
    2540                 2545                 2550             


Arg Val  Pro Thr Gln Pro His  Ala Pro Ile Pro Thr  Phe Gly Gln 
    2555                 2560                 2565             


Thr Ile  Gln Thr Thr Val Asp  Arg Gly Leu Leu Phe  Phe Ala Glu 
    2570                 2575                 2580             


Asn Gly  Asp Arg Phe Ile Ser  Leu Asn Ile Glu Asp  Gly Lys Leu 
    2585                 2590                 2595             


Met Val  Arg Tyr Lys Leu Asn  Ser Glu Leu Pro Lys  Glu Arg Gly 
    2600                 2605                 2610             


Val Gly  Asp Ala Ile Asn Asn  Gly Arg Asp His Ser  Ile Gln Ile 
    2615                 2620                 2625             


Lys Ile  Gly Lys Leu Gln Lys  Arg Met Trp Ile Asn  Val Asp Val 
    2630                 2635                 2640             


Gln Asn  Thr Ile Ile Asp Gly  Glu Val Phe Asp Phe  Ser Thr Tyr 
    2645                 2650                 2655             


Tyr Leu  Gly Gly Ile Pro Ile  Ala Ile Arg Glu Arg  Phe Asn Ile 
    2660                 2665                 2670             


Ser Thr  Pro Ala Phe Arg Gly  Cys Met Lys Asn Leu  Lys Lys Thr 
    2675                 2680                 2685             


Ser Gly  Val Val Arg Leu Asn  Asp Thr Val Gly Val  Thr Lys Lys 
    2690                 2695                 2700             


Cys Ser  Glu Asp Trp Lys Leu  Val Arg Ser Ala Ser  Phe Ser Arg 
    2705                 2710                 2715             


Gly Gly  Gln Leu Ser Phe Thr  Asp Leu Gly Leu Pro  Pro Thr Asp 
    2720                 2725                 2730             


His Leu  Gln Ala Ser Phe Gly  Phe Gln Thr Phe Gln  Pro Ser Gly 
    2735                 2740                 2745             


Ile Leu  Leu Asp His Gln Thr  Trp Thr Arg Asn Leu  Gln Val Thr 
    2750                 2755                 2760             


Leu Glu  Asp Gly Tyr Ile Glu  Leu Ser Thr Ser Asp  Ser Gly Ser 
    2765                 2770                 2775             


Pro Ile  Phe Lys Ser Pro Gln  Thr Tyr Met Asp Gly  Leu Leu His 
    2780                 2785                 2790             


Tyr Val  Ser Val Ile Ser Asp  Asn Ser Gly Leu Arg  Leu Leu Ile 
    2795                 2800                 2805             


Asp Asp  Gln Leu Leu Arg Asn  Ser Lys Arg Leu Lys  His Ile Ser 
    2810                 2815                 2820             


Ser Ser  Arg Gln Ser Leu Arg  Leu Gly Gly Ser Asn  Phe Glu Gly 
    2825                 2830                 2835             


Cys Ile  Ser Asn Val Phe Val  Gln Arg Leu Ser Leu  Ser Pro Glu 
    2840                 2845                 2850             


Val Leu  Asp Leu Thr Ser Asn  Ser Leu Lys Arg Asp  Val Ser Leu 
    2855                 2860                 2865             


Gly Gly  Cys Ser Leu Asn Lys  Pro Pro Phe Leu Met  Leu Leu Lys 
    2870                 2875                 2880             


Gly Ser  Thr Arg Phe Asn Lys  Thr Lys Thr Phe Arg  Ile Asn Gln 
    2885                 2890                 2895             


Leu Leu  Gln Asp Thr Pro Val  Ala Ser Pro Arg Ser  Val Lys Val 
    2900                 2905                 2910             


Trp Gln  Asp Ala Cys Ser Pro  Leu Pro Lys Thr Gln  Ala Asn His 
    2915                 2920                 2925             


Gly Ala  Leu Gln Phe Gly Asp  Ile Pro Thr Ser His  Leu Leu Phe 
    2930                 2935                 2940             


Lys Leu  Pro Gln Glu Leu Leu  Lys Pro Arg Ser Gln  Phe Ala Val 
    2945                 2950                 2955             


Asp Met  Gln Thr Thr Ser Ser  Arg Gly Leu Val Phe  His Thr Gly 
    2960                 2965                 2970             


Thr Lys  Asn Ser Phe Met Ala  Leu Tyr Leu Ser Lys  Gly Arg Leu 
    2975                 2980                 2985             


Val Phe  Ala Leu Gly Thr Asp  Gly Lys Lys Leu Arg  Ile Lys Ser 
    2990                 2995                 3000             


Lys Glu  Lys Cys Asn Asp Gly  Lys Trp His Thr Val  Val Phe Gly 
    3005                 3010                 3015             


His Asp  Gly Glu Lys Gly Arg  Leu Val Val Asp Gly  Leu Arg Ala 
    3020                 3025                 3030             


Arg Glu  Gly Ser Leu Pro Gly  Asn Ser Thr Ile Ser  Ile Arg Ala 
    3035                 3040                 3045             


Pro Val  Tyr Leu Gly Ser Pro  Pro Ser Gly Lys Pro  Lys Ser Leu 
    3050                 3055                 3060             


Pro Thr  Asn Ser Phe Val Gly  Cys Leu Lys Asn Phe  Gln Leu Asp 
    3065                 3070                 3075             


Ser Lys  Pro Leu Tyr Thr Pro  Ser Ser Ser Phe Gly  Val Ser Ser 
    3080                 3085                 3090             


Cys Leu  Gly Gly Pro Leu Glu  Lys Gly Ile Tyr Phe  Ser Glu Glu 
    3095                 3100                 3105             


Gly Gly  His Val Val Leu Ala  His Ser Val Leu Leu  Gly Pro Glu 
    3110                 3115                 3120             


Phe Lys  Leu Val Phe Ser Ile  Arg Pro Arg Ser Leu  Thr Gly Ile 
    3125                 3130                 3135             


Leu Ile  His Ile Gly Ser Gln  Pro Gly Lys His Leu  Cys Val Tyr 
    3140                 3145                 3150             


Leu Glu  Ala Gly Lys Val Thr  Ala Ser Met Asp Ser  Gly Ala Gly 
    3155                 3160                 3165             


Gly Thr  Ser Thr Ser Val Thr  Pro Lys Gln Ser Leu  Cys Asp Gly 
    3170                 3175                 3180             


Gln Trp  His Ser Val Ala Val  Thr Ile Lys Gln His  Ile Leu His 
    3185                 3190                 3195             


Leu Glu  Leu Asp Thr Asp Ser  Ser Tyr Thr Ala Gly  Gln Ile Pro 
    3200                 3205                 3210             


Phe Pro  Pro Ala Ser Thr Gln  Glu Pro Leu His Leu  Gly Gly Ala 
    3215                 3220                 3225             


Pro Ala  Asn Leu Thr Thr Leu  Arg Ile Pro Val Trp  Lys Ser Phe 
    3230                 3235                 3240             


Phe Gly  Cys Leu Arg Asn Ile  His Val Asn His Ile  Pro Val Pro 
    3245                 3250                 3255             


Val Thr  Glu Ala Leu Glu Val  Gln Gly Pro Val Ser  Leu Asn Gly 
    3260                 3265                 3270             


Cys Pro  Asp Gln 
    3275         


<210>  81
<211>  1724
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Pro Pro Ala Val Arg Arg Ser Ala Cys Ser Met Gly Trp Leu Trp 
1               5                   10                  15      


Ile Phe Gly Ala Ala Leu Gly Gln Cys Leu Gly Tyr Ser Ser Gln Gln 
            20                  25                  30          


Gln Arg Val Pro Phe Leu Gln Pro Pro Gly Gln Ser Gln Leu Gln Ala 
        35                  40                  45              


Ser Tyr Val Glu Phe Arg Pro Ser Gln Gly Cys Ser Pro Gly Tyr Tyr 
    50                  55                  60                  


Arg Asp His Lys Gly Leu Tyr Thr Gly Arg Cys Val Pro Cys Asn Cys 
65                  70                  75                  80  


Asn Gly His Ser Asn Gln Cys Gln Asp Gly Ser Gly Ile Cys Val Asn 
                85                  90                  95      


Cys Gln His Asn Thr Ala Gly Glu His Cys Glu Arg Cys Gln Glu Gly 
            100                 105                 110         


Tyr Tyr Gly Asn Ala Val His Gly Ser Cys Arg Ala Cys Pro Cys Pro 
        115                 120                 125             


His Thr Asn Ser Phe Ala Thr Gly Cys Val Val Asn Gly Gly Asp Val 
    130                 135                 140                 


Arg Cys Ser Cys Lys Ala Gly Tyr Thr Gly Thr Gln Cys Glu Arg Cys 
145                 150                 155                 160 


Ala Pro Gly Tyr Phe Gly Asn Pro Gln Lys Phe Gly Gly Ser Cys Gln 
                165                 170                 175     


Pro Cys Ser Cys Asn Ser Asn Gly Gln Leu Gly Ser Cys His Pro Leu 
            180                 185                 190         


Thr Gly Asp Cys Ile Asn Gln Glu Pro Lys Asp Ser Ser Pro Ala Glu 
        195                 200                 205             


Glu Cys Asp Asp Cys Asp Ser Cys Val Met Thr Leu Leu Asn Asp Leu 
    210                 215                 220                 


Ala Thr Met Gly Glu Gln Leu Arg Leu Val Lys Ser Gln Leu Gln Gly 
225                 230                 235                 240 


Leu Ser Ala Ser Ala Gly Leu Leu Glu Gln Met Arg His Met Glu Thr 
                245                 250                 255     


Gln Ala Lys Asp Leu Arg Asn Gln Leu Leu Asn Tyr Arg Ser Ala Ile 
            260                 265                 270         


Ser Asn His Gly Ser Lys Ile Glu Gly Leu Glu Arg Glu Leu Thr Asp 
        275                 280                 285             


Leu Asn Gln Glu Phe Glu Thr Leu Gln Glu Lys Ala Gln Val Asn Ser 
    290                 295                 300                 


Arg Lys Ala Gln Thr Leu Asn Asn Asn Val Asn Arg Ala Thr Gln Ser 
305                 310                 315                 320 


Ala Lys Glu Leu Asp Val Lys Ile Lys Asn Val Ile Arg Asn Val His 
                325                 330                 335     


Ile Leu Leu Lys Gln Ile Ser Gly Thr Asp Gly Glu Gly Asn Asn Val 
            340                 345                 350         


Pro Ser Gly Asp Phe Ser Arg Glu Trp Ala Glu Ala Gln Arg Met Met 
        355                 360                 365             


Arg Glu Leu Arg Asn Arg Asn Phe Gly Lys His Leu Arg Glu Ala Glu 
    370                 375                 380                 


Ala Asp Lys Arg Glu Ser Gln Leu Leu Leu Asn Arg Ile Arg Thr Trp 
385                 390                 395                 400 


Gln Lys Thr His Gln Gly Glu Asn Asn Gly Leu Ala Asn Ser Ile Arg 
                405                 410                 415     


Asp Ser Leu Asn Glu Tyr Glu Ala Lys Leu Ser Asp Leu Arg Ala Arg 
            420                 425                 430         


Leu Gln Glu Ala Ala Ala Gln Ala Lys Gln Ala Asn Gly Leu Asn Gln 
        435                 440                 445             


Glu Asn Glu Arg Ala Leu Gly Ala Ile Gln Arg Gln Val Lys Glu Ile 
    450                 455                 460                 


Asn Ser Leu Gln Ser Asp Phe Thr Lys Tyr Leu Thr Thr Ala Asp Ser 
465                 470                 475                 480 


Ser Leu Leu Gln Thr Asn Ile Ala Leu Gln Leu Met Glu Lys Ser Gln 
                485                 490                 495     


Lys Glu Tyr Glu Lys Leu Ala Ala Ser Leu Asn Glu Ala Arg Gln Glu 
            500                 505                 510         


Leu Ser Asp Lys Val Arg Glu Leu Ser Arg Ser Ala Gly Lys Thr Ser 
        515                 520                 525             


Leu Val Glu Glu Ala Glu Lys His Ala Arg Ser Leu Gln Glu Leu Ala 
    530                 535                 540                 


Lys Gln Leu Glu Glu Ile Lys Arg Asn Ala Ser Gly Asp Glu Leu Val 
545                 550                 555                 560 


Arg Cys Ala Val Asp Ala Ala Thr Ala Tyr Glu Asn Ile Leu Asn Ala 
                565                 570                 575     


Ile Lys Ala Ala Glu Asp Ala Ala Asn Arg Ala Ala Ser Ala Ser Glu 
            580                 585                 590         


Ser Ala Leu Gln Thr Val Ile Lys Glu Asp Leu Pro Arg Lys Ala Lys 
        595                 600                 605             


Thr Leu Ser Ser Asn Ser Asp Lys Leu Leu Asn Glu Ala Lys Met Thr 
    610                 615                 620                 


Gln Lys Lys Leu Lys Gln Glu Val Ser Pro Ala Leu Asn Asn Leu Gln 
625                 630                 635                 640 


Gln Thr Leu Asn Ile Val Thr Val Gln Lys Glu Val Ile Asp Thr Asn 
                645                 650                 655     


Leu Thr Thr Leu Arg Asp Gly Leu His Gly Ile Gln Arg Gly Asp Ile 
            660                 665                 670         


Asp Ala Met Ile Ser Ser Ala Lys Ser Met Val Arg Lys Ala Asn Asp 
        675                 680                 685             


Ile Thr Asp Glu Val Leu Asp Gly Leu Asn Pro Ile Gln Thr Asp Val 
    690                 695                 700                 


Glu Arg Ile Lys Asp Thr Tyr Gly Arg Thr Gln Asn Glu Asp Phe Lys 
705                 710                 715                 720 


Lys Ala Leu Thr Asp Ala Asp Asn Ser Val Asn Lys Leu Thr Asn Lys 
                725                 730                 735     


Leu Pro Asp Leu Trp Arg Lys Ile Glu Ser Ile Asn Gln Gln Leu Leu 
            740                 745                 750         


Pro Leu Gly Asn Ile Ser Asp Asn Met Asp Arg Ile Arg Glu Leu Ile 
        755                 760                 765             


Gln Gln Ala Arg Asp Ala Ala Ser Lys Val Ala Val Pro Met Arg Phe 
    770                 775                 780                 


Asn Gly Lys Ser Gly Val Glu Val Arg Leu Pro Asn Asp Leu Glu Asp 
785                 790                 795                 800 


Leu Lys Gly Tyr Thr Ser Leu Ser Leu Phe Leu Gln Arg Pro Asn Ser 
                805                 810                 815     


Arg Glu Asn Gly Gly Thr Glu Asn Met Phe Val Met Tyr Leu Gly Asn 
            820                 825                 830         


Lys Asp Ala Ser Arg Asp Tyr Ile Gly Met Ala Val Val Asp Gly Gln 
        835                 840                 845             


Leu Thr Cys Val Tyr Asn Leu Gly Asp Arg Glu Ala Glu Leu Gln Val 
    850                 855                 860                 


Asp Gln Ile Leu Thr Lys Ser Glu Thr Lys Glu Ala Val Met Asp Arg 
865                 870                 875                 880 


Val Lys Phe Gln Arg Ile Tyr Gln Phe Ala Arg Leu Asn Tyr Thr Lys 
                885                 890                 895     


Gly Ala Thr Ser Ser Lys Pro Glu Thr Pro Gly Val Tyr Asp Met Asp 
            900                 905                 910         


Gly Arg Asn Ser Asn Thr Leu Leu Asn Leu Asp Pro Glu Asn Val Val 
        915                 920                 925             


Phe Tyr Val Gly Gly Tyr Pro Pro Asp Phe Lys Leu Pro Ser Arg Leu 
    930                 935                 940                 


Ser Phe Pro Pro Tyr Lys Gly Cys Ile Glu Leu Asp Asp Leu Asn Glu 
945                 950                 955                 960 


Asn Val Leu Ser Leu Tyr Asn Phe Lys Lys Thr Phe Asn Leu Asn Thr 
                965                 970                 975     


Thr Glu Val Glu Pro Cys Arg Arg Arg Lys Glu Glu Ser Asp Lys Asn 
            980                 985                 990         


Tyr Phe Glu Gly Thr Gly Tyr Ala  Arg Val Pro Thr Gln  Pro His Ala 
        995                 1000                 1005             


Pro Ile  Pro Thr Phe Gly Gln  Thr Ile Gln Thr Thr  Val Asp Arg 
    1010                 1015                 1020             


Gly Leu  Leu Phe Phe Ala Glu  Asn Gly Asp Arg Phe  Ile Ser Leu 
    1025                 1030                 1035             


Asn Ile  Glu Asp Gly Lys Leu  Met Val Arg Tyr Lys  Leu Asn Ser 
    1040                 1045                 1050             


Glu Leu  Pro Lys Glu Arg Gly  Val Gly Asp Ala Ile  Asn Asn Gly 
    1055                 1060                 1065             


Arg Asp  His Ser Ile Gln Ile  Lys Ile Gly Lys Leu  Gln Lys Arg 
    1070                 1075                 1080             


Met Trp  Ile Asn Val Asp Val  Gln Asn Thr Ile Ile  Asp Gly Glu 
    1085                 1090                 1095             


Val Phe  Asp Phe Ser Thr Tyr  Tyr Leu Gly Gly Ile  Pro Ile Ala 
    1100                 1105                 1110             


Ile Arg  Glu Arg Phe Asn Ile  Ser Thr Pro Ala Phe  Arg Gly Cys 
    1115                 1120                 1125             


Met Lys  Asn Leu Lys Lys Thr  Ser Gly Val Val Arg  Leu Asn Asp 
    1130                 1135                 1140             


Thr Val  Gly Val Thr Lys Lys  Cys Ser Glu Asp Trp  Lys Leu Val 
    1145                 1150                 1155             


Arg Ser  Ala Ser Phe Ser Arg  Gly Gly Gln Leu Ser  Phe Thr Asp 
    1160                 1165                 1170             


Leu Gly  Leu Pro Pro Thr Asp  His Leu Gln Ala Ser  Phe Gly Phe 
    1175                 1180                 1185             


Gln Thr  Phe Gln Pro Ser Gly  Ile Leu Leu Asp His  Gln Thr Trp 
    1190                 1195                 1200             


Thr Arg  Asn Leu Gln Val Thr  Leu Glu Asp Gly Tyr  Ile Glu Leu 
    1205                 1210                 1215             


Ser Thr  Ser Asp Ser Gly Ser  Pro Ile Phe Lys Ser  Pro Gln Thr 
    1220                 1225                 1230             


Tyr Met  Asp Gly Leu Leu His  Tyr Val Ser Val Ile  Ser Asp Asn 
    1235                 1240                 1245             


Ser Gly  Leu Arg Leu Leu Ile  Asp Asp Gln Leu Leu  Arg Asn Ser 
    1250                 1255                 1260             


Lys Arg  Leu Lys His Ile Ser  Ser Ser Arg Gln Ser  Leu Arg Leu 
    1265                 1270                 1275             


Gly Gly  Ser Asn Phe Glu Gly  Cys Ile Ser Asn Val  Phe Val Gln 
    1280                 1285                 1290             


Arg Leu  Ser Leu Ser Pro Glu  Val Leu Asp Leu Thr  Ser Asn Ser 
    1295                 1300                 1305             


Leu Lys  Arg Asp Val Ser Leu  Gly Gly Cys Ser Leu  Asn Lys Pro 
    1310                 1315                 1320             


Pro Phe  Leu Met Leu Leu Lys  Gly Ser Thr Arg Phe  Asn Lys Thr 
    1325                 1330                 1335             


Lys Thr  Phe Arg Ile Asn Gln  Leu Leu Gln Asp Thr  Pro Val Ala 
    1340                 1345                 1350             


Ser Pro  Arg Ser Val Lys Val  Trp Gln Asp Ala Cys  Ser Pro Leu 
    1355                 1360                 1365             


Pro Lys  Thr Gln Ala Asn His  Gly Ala Leu Gln Phe  Gly Asp Ile 
    1370                 1375                 1380             


Pro Thr  Ser His Leu Leu Phe  Lys Leu Pro Gln Glu  Leu Leu Lys 
    1385                 1390                 1395             


Pro Arg  Ser Gln Phe Ala Val  Asp Met Gln Thr Thr  Ser Ser Arg 
    1400                 1405                 1410             


Gly Leu  Val Phe His Thr Gly  Thr Lys Asn Ser Phe  Met Ala Leu 
    1415                 1420                 1425             


Tyr Leu  Ser Lys Gly Arg Leu  Val Phe Ala Leu Gly  Thr Asp Gly 
    1430                 1435                 1440             


Lys Lys  Leu Arg Ile Lys Ser  Lys Glu Lys Cys Asn  Asp Gly Lys 
    1445                 1450                 1455             


Trp His  Thr Val Val Phe Gly  His Asp Gly Glu Lys  Gly Arg Leu 
    1460                 1465                 1470             


Val Val  Asp Gly Leu Arg Ala  Arg Glu Gly Ser Leu  Pro Gly Asn 
    1475                 1480                 1485             


Ser Thr  Ile Ser Ile Arg Ala  Pro Val Tyr Leu Gly  Ser Pro Pro 
    1490                 1495                 1500             


Ser Gly  Lys Pro Lys Ser Leu  Pro Thr Asn Ser Phe  Val Gly Cys 
    1505                 1510                 1515             


Leu Lys  Asn Phe Gln Leu Asp  Ser Lys Pro Leu Tyr  Thr Pro Ser 
    1520                 1525                 1530             


Ser Ser  Phe Gly Val Ser Ser  Cys Leu Gly Gly Pro  Leu Glu Lys 
    1535                 1540                 1545             


Gly Ile  Tyr Phe Ser Glu Glu  Gly Gly His Val Val  Leu Ala His 
    1550                 1555                 1560             


Ser Val  Leu Leu Gly Pro Glu  Phe Lys Leu Val Phe  Ser Ile Arg 
    1565                 1570                 1575             


Pro Arg  Ser Leu Thr Gly Ile  Leu Ile His Ile Gly  Ser Gln Pro 
    1580                 1585                 1590             


Gly Lys  His Leu Cys Val Tyr  Leu Glu Ala Gly Lys  Val Thr Ala 
    1595                 1600                 1605             


Ser Met  Asp Ser Gly Ala Gly  Gly Thr Ser Thr Ser  Val Thr Pro 
    1610                 1615                 1620             


Lys Gln  Ser Leu Cys Asp Gly  Gln Trp His Ser Val  Ala Val Thr 
    1625                 1630                 1635             


Ile Lys  Gln His Ile Leu His  Leu Glu Leu Asp Thr  Asp Ser Ser 
    1640                 1645                 1650             


Tyr Thr  Ala Gly Gln Ile Pro  Phe Pro Pro Ala Ser  Thr Gln Glu 
    1655                 1660                 1665             


Pro Leu  His Leu Gly Gly Ala  Pro Ala Asn Leu Thr  Thr Leu Arg 
    1670                 1675                 1680             


Ile Pro  Val Trp Lys Ser Phe  Phe Gly Cys Leu Arg  Asn Ile His 
    1685                 1690                 1695             


Val Asn  His Ile Pro Val Pro  Val Thr Glu Ala Leu  Glu Val Gln 
    1700                 1705                 1710             


Gly Pro  Val Ser Leu Asn Gly  Cys Pro Asp Gln 
    1715                 1720                 


<210>  82
<211>  1668
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Pro Pro Ala Val Arg Arg Ser Ala Cys Ser Met Gly Trp Leu Trp 
1               5                   10                  15      


Ile Phe Gly Ala Ala Leu Gly Gln Cys Leu Gly Tyr Ser Ser Gln Gln 
            20                  25                  30          


Gln Arg Val Pro Phe Leu Gln Pro Pro Gly Gln Ser Gln Leu Gln Ala 
        35                  40                  45              


Ser Tyr Val Glu Phe Arg Pro Ser Gln Gly Cys Ser Pro Gly Tyr Tyr 
    50                  55                  60                  


Arg Asp His Lys Gly Leu Tyr Thr Gly Arg Cys Val Pro Cys Asn Cys 
65                  70                  75                  80  


Asn Gly His Ser Asn Gln Cys Gln Asp Gly Ser Gly Ile Cys Val Asn 
                85                  90                  95      


Cys Gln His Asn Thr Ala Gly Glu His Cys Glu Arg Cys Gln Glu Gly 
            100                 105                 110         


Tyr Tyr Gly Asn Ala Val His Gly Ser Cys Arg Ala Cys Pro Cys Pro 
        115                 120                 125             


His Thr Asn Ser Phe Ala Thr Gly Cys Val Val Asn Gly Gly Asp Val 
    130                 135                 140                 


Arg Cys Ser Cys Lys Ala Gly Tyr Thr Gly Thr Gln Cys Glu Arg Cys 
145                 150                 155                 160 


Ala Pro Gly Tyr Phe Gly Asn Pro Gln Lys Phe Gly Gly Ser Cys Gln 
                165                 170                 175     


Pro Cys Ser Cys Asn Ser Asn Gly Gln Leu Gly Ser Cys His Pro Leu 
            180                 185                 190         


Thr Gly Asp Cys Ile Asn Gln Glu Pro Lys Asp Ser Ser Pro Ala Glu 
        195                 200                 205             


Glu Cys Asp Asp Cys Asp Ser Cys Val Met Thr Leu Leu Asn Asp Leu 
    210                 215                 220                 


Ala Thr Met Gly Glu Gln Leu Arg Leu Val Lys Ser Gln Leu Gln Gly 
225                 230                 235                 240 


Leu Ser Ala Ser Ala Gly Leu Leu Glu Gln Met Arg His Met Glu Thr 
                245                 250                 255     


Gln Ala Lys Asp Leu Arg Asn Gln Leu Leu Asn Tyr Arg Ser Ala Ile 
            260                 265                 270         


Ser Asn His Gly Ser Lys Ile Glu Gly Leu Glu Arg Glu Leu Thr Asp 
        275                 280                 285             


Leu Asn Gln Glu Phe Glu Thr Leu Gln Glu Lys Ala Gln Val Asn Ser 
    290                 295                 300                 


Arg Lys Ala Gln Thr Leu Asn Asn Asn Val Asn Arg Ala Thr Gln Ser 
305                 310                 315                 320 


Ala Lys Glu Leu Asp Val Lys Ile Lys Asn Val Ile Arg Asn Val His 
                325                 330                 335     


Met Leu Asn Arg Ile Arg Thr Trp Gln Lys Thr His Gln Gly Glu Asn 
            340                 345                 350         


Asn Gly Leu Ala Asn Ser Ile Arg Asp Ser Leu Asn Glu Tyr Glu Ala 
        355                 360                 365             


Lys Leu Ser Asp Leu Arg Ala Arg Leu Gln Glu Ala Ala Ala Gln Ala 
    370                 375                 380                 


Lys Gln Ala Asn Gly Leu Asn Gln Glu Asn Glu Arg Ala Leu Gly Ala 
385                 390                 395                 400 


Ile Gln Arg Gln Val Lys Glu Ile Asn Ser Leu Gln Ser Asp Phe Thr 
                405                 410                 415     


Lys Tyr Leu Thr Thr Ala Asp Ser Ser Leu Leu Gln Thr Asn Ile Ala 
            420                 425                 430         


Leu Gln Leu Met Glu Lys Ser Gln Lys Glu Tyr Glu Lys Leu Ala Ala 
        435                 440                 445             


Ser Leu Asn Glu Ala Arg Gln Glu Leu Ser Asp Lys Val Arg Glu Leu 
    450                 455                 460                 


Ser Arg Ser Ala Gly Lys Thr Ser Leu Val Glu Glu Ala Glu Lys His 
465                 470                 475                 480 


Ala Arg Ser Leu Gln Glu Leu Ala Lys Gln Leu Glu Glu Ile Lys Arg 
                485                 490                 495     


Asn Ala Ser Gly Asp Glu Leu Val Arg Cys Ala Val Asp Ala Ala Thr 
            500                 505                 510         


Ala Tyr Glu Asn Ile Leu Asn Ala Ile Lys Ala Ala Glu Asp Ala Ala 
        515                 520                 525             


Asn Arg Ala Ala Ser Ala Ser Glu Ser Ala Leu Gln Thr Val Ile Lys 
    530                 535                 540                 


Glu Asp Leu Pro Arg Lys Ala Lys Thr Leu Ser Ser Asn Ser Asp Lys 
545                 550                 555                 560 


Leu Leu Asn Glu Ala Lys Met Thr Gln Lys Lys Leu Lys Gln Glu Val 
                565                 570                 575     


Ser Pro Ala Leu Asn Asn Leu Gln Gln Thr Leu Asn Ile Val Thr Val 
            580                 585                 590         


Gln Lys Glu Val Ile Asp Thr Asn Leu Thr Thr Leu Arg Asp Gly Leu 
        595                 600                 605             


His Gly Ile Gln Arg Gly Asp Ile Asp Ala Met Ile Ser Ser Ala Lys 
    610                 615                 620                 


Ser Met Val Arg Lys Ala Asn Asp Ile Thr Asp Glu Val Leu Asp Gly 
625                 630                 635                 640 


Leu Asn Pro Ile Gln Thr Asp Val Glu Arg Ile Lys Asp Thr Tyr Gly 
                645                 650                 655     


Arg Thr Gln Asn Glu Asp Phe Lys Lys Ala Leu Thr Asp Ala Asp Asn 
            660                 665                 670         


Ser Val Asn Lys Leu Thr Asn Lys Leu Pro Asp Leu Trp Arg Lys Ile 
        675                 680                 685             


Glu Ser Ile Asn Gln Gln Leu Leu Pro Leu Gly Asn Ile Ser Asp Asn 
    690                 695                 700                 


Met Asp Arg Ile Arg Glu Leu Ile Gln Gln Ala Arg Asp Ala Ala Ser 
705                 710                 715                 720 


Lys Val Ala Val Pro Met Arg Phe Asn Gly Lys Ser Gly Val Glu Val 
                725                 730                 735     


Arg Leu Pro Asn Asp Leu Glu Asp Leu Lys Gly Tyr Thr Ser Leu Ser 
            740                 745                 750         


Leu Phe Leu Gln Arg Pro Asn Ser Arg Glu Asn Gly Gly Thr Glu Asn 
        755                 760                 765             


Met Phe Val Met Tyr Leu Gly Asn Lys Asp Ala Ser Arg Asp Tyr Ile 
    770                 775                 780                 


Gly Met Ala Val Val Asp Gly Gln Leu Thr Cys Val Tyr Asn Leu Gly 
785                 790                 795                 800 


Asp Arg Glu Ala Glu Leu Gln Val Asp Gln Ile Leu Thr Lys Ser Glu 
                805                 810                 815     


Thr Lys Glu Ala Val Met Asp Arg Val Lys Phe Gln Arg Ile Tyr Gln 
            820                 825                 830         


Phe Ala Arg Leu Asn Tyr Thr Lys Gly Ala Thr Ser Ser Lys Pro Glu 
        835                 840                 845             


Thr Pro Gly Val Tyr Asp Met Asp Gly Arg Asn Ser Asn Thr Leu Leu 
    850                 855                 860                 


Asn Leu Asp Pro Glu Asn Val Val Phe Tyr Val Gly Gly Tyr Pro Pro 
865                 870                 875                 880 


Asp Phe Lys Leu Pro Ser Arg Leu Ser Phe Pro Pro Tyr Lys Gly Cys 
                885                 890                 895     


Ile Glu Leu Asp Asp Leu Asn Glu Asn Val Leu Ser Leu Tyr Asn Phe 
            900                 905                 910         


Lys Lys Thr Phe Asn Leu Asn Thr Thr Glu Val Glu Pro Cys Arg Arg 
        915                 920                 925             


Arg Lys Glu Glu Ser Asp Lys Asn Tyr Phe Glu Gly Thr Gly Tyr Ala 
    930                 935                 940                 


Arg Val Pro Thr Gln Pro His Ala Pro Ile Pro Thr Phe Gly Gln Thr 
945                 950                 955                 960 


Ile Gln Thr Thr Val Asp Arg Gly Leu Leu Phe Phe Ala Glu Asn Gly 
                965                 970                 975     


Asp Arg Phe Ile Ser Leu Asn Ile Glu Asp Gly Lys Leu Met Val Arg 
            980                 985                 990         


Tyr Lys Leu Asn Ser Glu Leu Pro  Lys Glu Arg Gly Val  Gly Asp Ala 
        995                 1000                 1005             


Ile Asn  Asn Gly Arg Asp His  Ser Ile Gln Ile Lys  Ile Gly Lys 
    1010                 1015                 1020             


Leu Gln  Lys Arg Met Trp Ile  Asn Val Asp Val Gln  Asn Thr Ile 
    1025                 1030                 1035             


Ile Asp  Gly Glu Val Phe Asp  Phe Ser Thr Tyr Tyr  Leu Gly Gly 
    1040                 1045                 1050             


Ile Pro  Ile Ala Ile Arg Glu  Arg Phe Asn Ile Ser  Thr Pro Ala 
    1055                 1060                 1065             


Phe Arg  Gly Cys Met Lys Asn  Leu Lys Lys Thr Ser  Gly Val Val 
    1070                 1075                 1080             


Arg Leu  Asn Asp Thr Val Gly  Val Thr Lys Lys Cys  Ser Glu Asp 
    1085                 1090                 1095             


Trp Lys  Leu Val Arg Ser Ala  Ser Phe Ser Arg Gly  Gly Gln Leu 
    1100                 1105                 1110             


Ser Phe  Thr Asp Leu Gly Leu  Pro Pro Thr Asp His  Leu Gln Ala 
    1115                 1120                 1125             


Ser Phe  Gly Phe Gln Thr Phe  Gln Pro Ser Gly Ile  Leu Leu Asp 
    1130                 1135                 1140             


His Gln  Thr Trp Thr Arg Asn  Leu Gln Val Thr Leu  Glu Asp Gly 
    1145                 1150                 1155             


Tyr Ile  Glu Leu Ser Thr Ser  Asp Ser Gly Ser Pro  Ile Phe Lys 
    1160                 1165                 1170             


Ser Pro  Gln Thr Tyr Met Asp  Gly Leu Leu His Tyr  Val Ser Val 
    1175                 1180                 1185             


Ile Ser  Asp Asn Ser Gly Leu  Arg Leu Leu Ile Asp  Asp Gln Leu 
    1190                 1195                 1200             


Leu Arg  Asn Ser Lys Arg Leu  Lys His Ile Ser Ser  Ser Arg Gln 
    1205                 1210                 1215             


Ser Leu  Arg Leu Gly Gly Ser  Asn Phe Glu Gly Cys  Ile Ser Asn 
    1220                 1225                 1230             


Val Phe  Val Gln Arg Leu Ser  Leu Ser Pro Glu Val  Leu Asp Leu 
    1235                 1240                 1245             


Thr Ser  Asn Ser Leu Lys Arg  Asp Val Ser Leu Gly  Gly Cys Ser 
    1250                 1255                 1260             


Leu Asn  Lys Pro Pro Phe Leu  Met Leu Leu Lys Gly  Ser Thr Arg 
    1265                 1270                 1275             


Phe Asn  Lys Thr Lys Thr Phe  Arg Ile Asn Gln Leu  Leu Gln Asp 
    1280                 1285                 1290             


Thr Pro  Val Ala Ser Pro Arg  Ser Val Lys Val Trp  Gln Asp Ala 
    1295                 1300                 1305             


Cys Ser  Pro Leu Pro Lys Thr  Gln Ala Asn His Gly  Ala Leu Gln 
    1310                 1315                 1320             


Phe Gly  Asp Ile Pro Thr Ser  His Leu Leu Phe Lys  Leu Pro Gln 
    1325                 1330                 1335             


Glu Leu  Leu Lys Pro Arg Ser  Gln Phe Ala Val Asp  Met Gln Thr 
    1340                 1345                 1350             


Thr Ser  Ser Arg Gly Leu Val  Phe His Thr Gly Thr  Lys Asn Ser 
    1355                 1360                 1365             


Phe Met  Ala Leu Tyr Leu Ser  Lys Gly Arg Leu Val  Phe Ala Leu 
    1370                 1375                 1380             


Gly Thr  Asp Gly Lys Lys Leu  Arg Ile Lys Ser Lys  Glu Lys Cys 
    1385                 1390                 1395             


Asn Asp  Gly Lys Trp His Thr  Val Val Phe Gly His  Asp Gly Glu 
    1400                 1405                 1410             


Lys Gly  Arg Leu Val Val Asp  Gly Leu Arg Ala Arg  Glu Gly Ser 
    1415                 1420                 1425             


Leu Pro  Gly Asn Ser Thr Ile  Ser Ile Arg Ala Pro  Val Tyr Leu 
    1430                 1435                 1440             


Gly Ser  Pro Pro Ser Gly Lys  Pro Lys Ser Leu Pro  Thr Asn Ser 
    1445                 1450                 1455             


Phe Val  Gly Cys Leu Lys Asn  Phe Gln Leu Asp Ser  Lys Pro Leu 
    1460                 1465                 1470             


Tyr Thr  Pro Ser Ser Ser Phe  Gly Val Ser Ser Cys  Leu Gly Gly 
    1475                 1480                 1485             


Pro Leu  Glu Lys Gly Ile Tyr  Phe Ser Glu Glu Gly  Gly His Val 
    1490                 1495                 1500             


Val Leu  Ala His Ser Val Leu  Leu Gly Pro Glu Phe  Lys Leu Val 
    1505                 1510                 1515             


Phe Ser  Ile Arg Pro Arg Ser  Leu Thr Gly Ile Leu  Ile His Ile 
    1520                 1525                 1530             


Gly Ser  Gln Pro Gly Lys His  Leu Cys Val Tyr Leu  Glu Ala Gly 
    1535                 1540                 1545             


Lys Val  Thr Ala Ser Met Asp  Ser Gly Ala Gly Gly  Thr Ser Thr 
    1550                 1555                 1560             


Ser Val  Thr Pro Lys Gln Ser  Leu Cys Asp Gly Gln  Trp His Ser 
    1565                 1570                 1575             


Val Ala  Val Thr Ile Lys Gln  His Ile Leu His Leu  Glu Leu Asp 
    1580                 1585                 1590             


Thr Asp  Ser Ser Tyr Thr Ala  Gly Gln Ile Pro Phe  Pro Pro Ala 
    1595                 1600                 1605             


Ser Thr  Gln Glu Pro Leu His  Leu Gly Gly Ala Pro  Ala Asn Leu 
    1610                 1615                 1620             


Thr Thr  Leu Arg Ile Pro Val  Trp Lys Ser Phe Phe  Gly Cys Leu 
    1625                 1630                 1635             


Arg Asn  Ile His Val Asn His  Ile Pro Val Pro Val  Thr Glu Ala 
    1640                 1645                 1650             


Leu Glu  Val Gln Gly Pro Val  Ser Leu Asn Gly Cys  Pro Asp Gln 
    1655                 1660                 1665             


<210>  83
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  84
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Arg Ser Pro Gly Ser Ala Glu Ser Pro Gly Gly 
                165                 170                 175     


Asp Pro His His Leu Arg Asp Pro Val Cys His Pro Leu Gly Ala Gly 
            180                 185                 190         


Leu Tyr Gln Lys Gly Gly Gln Glu Ala Asn Gln 
        195                 200             


<210>  85
<211>  1497
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Asp Val Thr Lys Lys Asn Lys Arg Asp Gly Thr Glu Val Thr Glu 
1               5                   10                  15      


Arg Ile Val Thr Glu Thr Val Thr Thr Arg Leu Thr Ser Leu Pro Pro 
            20                  25                  30          


Lys Gly Gly Thr Ser Asn Gly Tyr Ala Lys Thr Ala Ser Leu Gly Gly 
        35                  40                  45              


Gly Ser Arg Leu Glu Lys Gln Ser Leu Thr His Gly Ser Ser Gly Tyr 
    50                  55                  60                  


Ile Asn Ser Thr Gly Ser Thr Arg Gly His Ala Ser Thr Ser Ser Tyr 
65                  70                  75                  80  


Arg Arg Ala His Ser Pro Ala Ser Thr Leu Pro Asn Ser Pro Gly Ser 
                85                  90                  95      


Thr Phe Glu Arg Lys Thr His Val Thr Arg His Ala Tyr Glu Gly Ser 
            100                 105                 110         


Ser Ser Gly Asn Ser Ser Pro Glu Tyr Pro Arg Lys Glu Phe Ala Ser 
        115                 120                 125             


Ser Ser Thr Arg Gly Arg Ser Gln Thr Arg Glu Ser Glu Ile Arg Val 
    130                 135                 140                 


Arg Leu Gln Ser Ala Ser Pro Ser Thr Arg Trp Thr Glu Leu Asp Asp 
145                 150                 155                 160 


Val Lys Arg Leu Leu Lys Gly Ser Arg Ser Ala Ser Val Ser Pro Thr 
                165                 170                 175     


Arg Asn Ser Ser Asn Thr Leu Pro Ile Pro Lys Lys Gly Thr Val Glu 
            180                 185                 190         


Thr Lys Ile Val Thr Ala Ser Ser Gln Ser Val Ser Gly Thr Tyr Asp 
        195                 200                 205             


Ala Thr Ile Leu Asp Ala Asn Leu Pro Ser His Val Trp Ser Ser Thr 
    210                 215                 220                 


Leu Pro Ala Gly Ser Ser Met Gly Thr Tyr His Asn Asn Met Thr Thr 
225                 230                 235                 240 


Gln Ser Ser Ser Leu Leu Asn Thr Asn Ala Tyr Ser Ala Gly Ser Val 
                245                 250                 255     


Phe Gly Val Pro Asn Asn Met Ala Ser Cys Ser Pro Thr Leu His Pro 
            260                 265                 270         


Gly Leu Ser Thr Ser Ser Ser Val Phe Gly Met Gln Asn Asn Leu Ala 
        275                 280                 285             


Pro Ser Leu Thr Thr Leu Ser His Gly Thr Thr Thr Thr Ser Thr Ala 
    290                 295                 300                 


Tyr Gly Val Lys Lys Asn Met Pro Gln Ser Pro Ala Ala Val Asn Thr 
305                 310                 315                 320 


Gly Val Ser Thr Ser Ala Ala Cys Thr Thr Ser Val Gln Ser Asp Asp 
                325                 330                 335     


Leu Leu His Lys Asp Cys Lys Phe Leu Ile Leu Glu Lys Asp Asn Thr 
            340                 345                 350         


Pro Ala Lys Lys Glu Met Glu Leu Leu Ile Met Thr Lys Asp Ser Gly 
        355                 360                 365             


Lys Val Phe Thr Ala Ser Pro Ala Ser Ile Ala Ala Thr Ser Phe Ser 
    370                 375                 380                 


Glu Asp Thr Leu Lys Lys Glu Lys Gln Ala Ala Tyr Asn Ala Asp Ser 
385                 390                 395                 400 


Gly Leu Lys Ala Glu Ala Asn Gly Asp Leu Lys Thr Val Ser Thr Lys 
                405                 410                 415     


Gly Lys Thr Thr Thr Ala Asp Ile His Ser Tyr Gly Ser Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Gly Val Gly Gly Ala Gly Gly Gly Pro 
        435                 440                 445             


Trp Gly Pro Ala Pro Ala Trp Cys Pro Cys Gly Ser Cys Cys Ser Trp 
    450                 455                 460                 


Trp Lys Trp Leu Leu Gly Leu Leu Leu Thr Trp Leu Leu Leu Leu Gly 
465                 470                 475                 480 


Leu Leu Phe Gly Leu Ile Ala Leu Ala Glu Glu Val Arg Lys Leu Lys 
                485                 490                 495     


Ala Arg Val Asp Glu Leu Glu Arg Ile Arg Arg Ser Ile Leu Pro Tyr 
            500                 505                 510         


Gly Asp Ser Met Asp Arg Ile Glu Lys Asp Arg Leu Gln Gly Met Ala 
        515                 520                 525             


Pro Ala Ala Gly Ala Asp Leu Asp Lys Ile Gly Leu His Ser Asp Ser 
    530                 535                 540                 


Gln Glu Glu Leu Trp Met Phe Val Arg Lys Lys Leu Met Met Glu Gln 
545                 550                 555                 560 


Glu Asn Gly Asn Leu Arg Gly Ser Pro Gly Pro Lys Gly Asp Met Gly 
                565                 570                 575     


Ser Pro Gly Pro Lys Gly Asp Arg Gly Phe Pro Gly Thr Pro Gly Ile 
            580                 585                 590         


Pro Gly Pro Leu Gly His Pro Gly Pro Gln Gly Pro Lys Gly Gln Lys 
        595                 600                 605             


Gly Ser Val Gly Asp Pro Gly Met Glu Gly Pro Met Gly Gln Arg Gly 
    610                 615                 620                 


Arg Glu Gly Pro Met Gly Pro Arg Gly Glu Ala Gly Pro Pro Gly Ser 
625                 630                 635                 640 


Gly Glu Lys Gly Glu Arg Gly Ala Ala Gly Glu Pro Gly Pro His Gly 
                645                 650                 655     


Pro Pro Gly Val Pro Gly Ser Val Gly Pro Lys Gly Ser Ser Gly Ser 
            660                 665                 670         


Pro Gly Pro Gln Gly Pro Pro Gly Pro Val Gly Leu Gln Gly Leu Arg 
        675                 680                 685             


Gly Glu Val Gly Leu Pro Gly Val Lys Gly Asp Lys Gly Pro Met Gly 
    690                 695                 700                 


Pro Pro Gly Pro Lys Gly Asp Gln Gly Glu Lys Gly Pro Arg Gly Leu 
705                 710                 715                 720 


Thr Gly Glu Pro Gly Met Arg Gly Leu Pro Gly Ala Val Gly Glu Pro 
                725                 730                 735     


Gly Ala Lys Gly Ala Met Gly Pro Ala Gly Pro Asp Gly His Gln Gly 
            740                 745                 750         


Pro Arg Gly Glu Gln Gly Leu Thr Gly Met Pro Gly Ile Arg Gly Pro 
        755                 760                 765             


Pro Gly Pro Ser Gly Asp Pro Gly Lys Pro Gly Leu Thr Gly Pro Gln 
    770                 775                 780                 


Gly Pro Gln Gly Leu Pro Gly Thr Pro Gly Arg Pro Gly Ile Lys Gly 
785                 790                 795                 800 


Glu Pro Gly Ala Pro Gly Lys Ile Val Thr Ser Glu Gly Ser Ser Met 
                805                 810                 815     


Leu Thr Val Pro Gly Pro Pro Gly Pro Pro Gly Ala Met Gly Pro Pro 
            820                 825                 830         


Gly Pro Pro Gly Ala Pro Gly Pro Ala Gly Pro Ala Gly Leu Pro Gly 
        835                 840                 845             


His Gln Glu Val Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro 
    850                 855                 860                 


Arg Gly Pro Pro Gly Pro Ser Ile Pro Gly Pro Pro Gly Pro Arg Gly 
865                 870                 875                 880 


Pro Pro Gly Glu Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Ser Phe 
                885                 890                 895     


Leu Ser Asn Ser Glu Thr Phe Leu Ser Gly Pro Pro Gly Pro Pro Gly 
            900                 905                 910         


Pro Pro Gly Pro Lys Gly Asp Gln Gly Pro Pro Gly Pro Arg Gly His 
        915                 920                 925             


Gln Gly Glu Gln Gly Leu Pro Gly Phe Ser Thr Ser Gly Ser Ser Ser 
    930                 935                 940                 


Phe Gly Leu Asn Leu Gln Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly 
945                 950                 955                 960 


Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Pro Gly Ala Leu Gly Ile 
                965                 970                 975     


Pro Ser Gly Pro Ser Glu Gly Gly Ser Ser Ser Thr Met Tyr Val Ser 
            980                 985                 990         


Gly Pro Pro Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Ser Ile Ser 
        995                 1000                 1005             


Ser Ser  Gly Gln Glu Ile Gln  Gln Tyr Ile Ser Glu  Tyr Met Gln 
    1010                 1015                 1020             


Ser Asp  Ser Ile Arg Ser Tyr  Leu Ser Gly Val Gln  Gly Pro Pro 
    1025                 1030                 1035             


Gly Pro  Pro Gly Pro Pro Gly  Pro Val Thr Thr Ile  Thr Gly Glu 
    1040                 1045                 1050             


Thr Phe  Asp Tyr Ser Glu Leu  Ala Ser His Val Val  Ser Tyr Leu 
    1055                 1060                 1065             


Arg Thr  Ser Gly Tyr Gly Val  Ser Leu Phe Ser Ser  Ser Ile Ser 
    1070                 1075                 1080             


Ser Glu  Asp Ile Leu Ala Val  Leu Gln Arg Asp Asp  Val Arg Gln 
    1085                 1090                 1095             


Tyr Leu  Arg Gln Tyr Leu Met  Gly Pro Arg Gly Pro  Pro Gly Pro 
    1100                 1105                 1110             


Pro Gly  Ala Ser Gly Asp Gly  Ser Leu Leu Ser Leu  Asp Tyr Ala 
    1115                 1120                 1125             


Glu Leu  Ser Ser Arg Ile Leu  Ser Tyr Met Ser Ser  Ser Gly Ile 
    1130                 1135                 1140             


Ser Ile  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Leu Pro Gly 
    1145                 1150                 1155             


Thr Ser  Tyr Glu Glu Leu Leu  Ser Leu Leu Arg Gly  Ser Glu Phe 
    1160                 1165                 1170             


Arg Gly  Ile Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Ile 
    1175                 1180                 1185             


Pro Gly  Asn Val Trp Ser Ser  Ile Ser Val Glu Asp  Leu Ser Ser 
    1190                 1195                 1200             


Tyr Leu  His Thr Ala Gly Leu  Ser Phe Ile Pro Gly  Pro Pro Gly 
    1205                 1210                 1215             


Pro Pro  Gly Pro Pro Gly Pro  Arg Gly Pro Pro Gly  Val Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Thr Tyr Ala Ala  Glu Asn Ser Asp Ser  Phe Arg Ser 
    1235                 1240                 1245             


Glu Leu  Ile Ser Tyr Leu Thr  Ser Pro Asp Val Arg  Ser Phe Ile 
    1250                 1255                 1260             


Val Gly  Pro Pro Gly Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Asp 
    1265                 1270                 1275             


Ser Arg  Leu Leu Ser Thr Asp  Ala Ser His Ser Arg  Gly Ser Ser 
    1280                 1285                 1290             


Ser Ser  Ser His Ser Ser Ser  Val Arg Arg Gly Ser  Ser Tyr Ser 
    1295                 1300                 1305             


Ser Ser  Met Ser Thr Gly Gly  Gly Gly Ala Gly Ser  Leu Gly Ala 
    1310                 1315                 1320             


Gly Gly  Ala Phe Gly Glu Ala  Ala Gly Asp Arg Gly  Pro Tyr Gly 
    1325                 1330                 1335             


Thr Asp  Ile Gly Pro Gly Gly  Gly Tyr Gly Ala Ala  Ala Glu Gly 
    1340                 1345                 1350             


Gly Met  Tyr Ala Gly Asn Gly  Gly Leu Leu Gly Ala  Asp Phe Ala 
    1355                 1360                 1365             


Gly Asp  Leu Asp Tyr Asn Glu  Leu Ala Val Arg Val  Ser Glu Ser 
    1370                 1375                 1380             


Met Gln  Arg Gln Gly Leu Leu  Gln Gly Met Ala Tyr  Thr Val Gln 
    1385                 1390                 1395             


Gly Pro  Pro Gly Gln Pro Gly  Pro Gln Gly Pro Pro  Gly Ile Ser 
    1400                 1405                 1410             


Lys Val  Phe Ser Ala Tyr Ser  Asn Val Thr Ala Asp  Leu Met Asp 
    1415                 1420                 1425             


Phe Phe  Gln Thr Tyr Gly Ala  Ile Gln Gly Pro Pro  Gly Gln Lys 
    1430                 1435                 1440             


Gly Glu  Met Gly Thr Pro Gly  Pro Lys Gly Asp Arg  Gly Pro Ala 
    1445                 1450                 1455             


Gly Pro  Pro Gly His Pro Gly  Pro Pro Gly Pro Arg  Gly His Lys 
    1460                 1465                 1470             


Gly Glu  Lys Gly Asp Lys Gly  Asp Gln Val Tyr Ala  Gly Arg Arg 
    1475                 1480                 1485             


Arg Arg  Arg Ser Ile Ala Val  Lys Pro 
    1490                 1495         


<210>  86
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Glu Ala Ala Arg Pro Ser Gly Ser Trp Asn Gly Ala Leu Cys Arg 
1               5                   10                  15      


Leu Leu Leu Leu Thr Leu Ala Ile Leu Ile Phe Ala Ser Asp Ala Cys 
            20                  25                  30          


Lys Asn Val Thr Leu His Val Pro Ser Lys Leu Asp Ala Glu Lys Leu 
        35                  40                  45              


Val Gly Arg Val Asn Leu Lys Glu Cys Phe Thr Ala Ala Asn Leu Ile 
    50                  55                  60                  


His Ser Ser Asp Pro Asp Phe Gln Ile Leu Glu Asp Gly Ser Val Tyr 
65                  70                  75                  80  


Thr Thr Asn Thr Ile Leu Leu Ser Ser Glu Lys Arg Ser Phe Thr Ile 
                85                  90                  95      


Leu Leu Ser Asn Thr Glu Asn Gln Glu Lys Lys Lys Ile Phe Val Phe 
            100                 105                 110         


Leu Glu His Gln Thr Lys Val Leu Lys Lys Arg His Thr Lys Glu Lys 
        115                 120                 125             


Val Leu Arg Arg Ala Lys Arg Arg Trp Ala Pro Ile Pro Cys Ser Met 
    130                 135                 140                 


Leu Glu Asn Ser Leu Gly Pro Phe Pro Leu Phe Leu Gln Gln Val Gln 
145                 150                 155                 160 


Ser Asp Thr Ala Gln Asn Tyr Thr Ile Tyr Tyr Ser Ile Arg Gly Pro 
                165                 170                 175     


Gly Val Asp Gln Glu Pro Arg Asn Leu Phe Tyr Val Glu Arg Asp Thr 
            180                 185                 190         


Gly Asn Leu Tyr Cys Thr Arg Pro Val Asp Arg Glu Gln Tyr Glu Ser 
        195                 200                 205             


Phe Glu Ile Ile Ala Phe Ala Thr Thr Pro Asp Gly Tyr Thr Pro Glu 
    210                 215                 220                 


Leu Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Glu Asn Asp Asn Tyr 
225                 230                 235                 240 


Pro Ile Phe Thr Glu Glu Thr Tyr Thr Phe Thr Ile Phe Glu Asn Cys 
                245                 250                 255     


Arg Val Gly Thr Thr Val Gly Gln Val Cys Ala Thr Asp Lys Asp Glu 
            260                 265                 270         


Pro Asp Thr Met His Thr Arg Leu Lys Tyr Ser Ile Ile Gly Gln Val 
        275                 280                 285             


Pro Pro Ser Pro Thr Leu Phe Ser Met His Pro Thr Thr Gly Val Ile 
    290                 295                 300                 


Thr Thr Thr Ser Ser Gln Leu Asp Arg Glu Leu Ile Asp Lys Tyr Gln 
305                 310                 315                 320 


Leu Lys Ile Lys Val Gln Asp Met Asp Gly Gln Tyr Phe Gly Leu Gln 
                325                 330                 335     


Thr Thr Ser Thr Cys Ile Ile Asn Ile Asp Asp Val Asn Asp His Leu 
            340                 345                 350         


Pro Thr Phe Thr Arg Thr Ser Tyr Val Thr Ser Val Glu Glu Asn Thr 
        355                 360                 365             


Val Asp Val Glu Ile Leu Arg Val Thr Val Glu Asp Lys Asp Leu Val 
    370                 375                 380                 


Asn Thr Ala Asn Trp Arg Ala Asn Tyr Thr Ile Leu Lys Gly Asn Glu 
385                 390                 395                 400 


Asn Gly Asn Phe Lys Ile Val Thr Asp Ala Lys Thr Asn Glu Gly Val 
                405                 410                 415     


Leu Cys Val Val Lys Pro Leu Asn Tyr Glu Glu Lys Gln Gln Met Ile 
            420                 425                 430         


Leu Gln Ile Gly Val Val Asn Glu Ala Pro Phe Ser Arg Glu Ala Ser 
        435                 440                 445             


Pro Arg Ser Ala Met Ser Thr Ala Thr Val Thr Val Asn Val Glu Asp 
    450                 455                 460                 


Gln Asp Glu Gly Pro Glu Cys Asn Pro Pro Ile Gln Thr Val Arg Met 
465                 470                 475                 480 


Lys Glu Asn Ala Glu Val Gly Thr Thr Ser Asn Gly Tyr Lys Ala Tyr 
                485                 490                 495     


Asp Pro Glu Thr Arg Ser Ser Ser Gly Ile Arg Tyr Lys Lys Leu Thr 
            500                 505                 510         


Asp Pro Thr Gly Trp Val Thr Ile Asp Glu Asn Thr Gly Ser Ile Lys 
        515                 520                 525             


Val Phe Arg Ser Leu Asp Arg Glu Ala Glu Thr Ile Lys Asn Gly Ile 
    530                 535                 540                 


Tyr Asn Ile Thr Val Leu Ala Ser Asp Gln Gly Gly Arg Thr Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Gly Ile Ile Leu Gln Asp Val Asn Asp Asn Ser Pro Phe 
                565                 570                 575     


Ile Pro Lys Lys Thr Val Ile Ile Cys Lys Pro Thr Met Ser Ser Ala 
            580                 585                 590         


Glu Ile Val Ala Val Asp Pro Asp Glu Pro Ile His Gly Pro Pro Phe 
        595                 600                 605             


Asp Phe Ser Leu Glu Ser Ser Thr Ser Glu Val Gln Arg Met Trp Arg 
    610                 615                 620                 


Leu Lys Ala Ile Asn Asp Thr Ala Ala Arg Leu Ser Tyr Gln Asn Asp 
625                 630                 635                 640 


Pro Pro Phe Gly Ser Tyr Val Val Pro Ile Thr Val Arg Asp Arg Leu 
                645                 650                 655     


Gly Met Ser Ser Val Thr Ser Leu Asp Val Thr Leu Cys Asp Cys Ile 
            660                 665                 670         


Thr Glu Asn Asp Cys Thr His Arg Val Asp Pro Arg Ile Gly Gly Gly 
        675                 680                 685             


Gly Val Gln Leu Gly Lys Trp Ala Ile Leu Ala Ile Leu Leu Gly Ile 
    690                 695                 700                 


Ala Leu Leu Phe Cys Ile Leu Phe Thr Leu Val Cys Gly Ala Ser Gly 
705                 710                 715                 720 


Thr Ser Lys Gln Pro Lys Val Ile Pro Asp Asp Leu Ala Gln Gln Asn 
                725                 730                 735     


Leu Ile Val Ser Asn Thr Glu Ala Pro Gly Asp Asp Lys Val Tyr Ser 
            740                 745                 750         


Ala Asn Gly Phe Thr Thr Gln Thr Val Gly Ala Ser Ala Gln Gly Val 
        755                 760                 765             


Cys Gly Thr Val Gly Ser Gly Ile Lys Asn Gly Gly Gln Glu Thr Ile 
    770                 775                 780                 


Glu Met Val Lys Gly Gly His Gln Thr Ser Glu Ser Cys Arg Gly Ala 
785                 790                 795                 800 


Gly His His His Thr Leu Asp Ser Cys Arg Gly Gly His Thr Glu Val 
                805                 810                 815     


Asp Asn Cys Arg Tyr Thr Tyr Ser Glu Trp His Ser Phe Thr Gln Pro 
            820                 825                 830         


Arg Leu Gly Glu Lys Val Tyr Leu Cys Asn Gln Asp Glu Asn His Lys 
        835                 840                 845             


His Ala Gln Asp Tyr Val Leu Thr Tyr Asn Tyr Glu Gly Arg Gly Ser 
    850                 855                 860                 


Val Ala Gly Ser Val Gly Cys Cys Ser Glu Arg Gln Glu Glu Asp Gly 
865                 870                 875                 880 


Leu Glu Phe Leu Asp Asn Leu Glu Pro Lys Phe Arg Thr Leu Ala Glu 
                885                 890                 895     


Ala Cys Met Lys Arg 
            900     


<210>  87
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Glu Ala Ala Arg Pro Ser Gly Ser Trp Asn Gly Ala Leu Cys Arg 
1               5                   10                  15      


Leu Leu Leu Leu Thr Leu Ala Ile Leu Ile Phe Ala Ser Asp Ala Cys 
            20                  25                  30          


Lys Asn Val Thr Leu His Val Pro Ser Lys Leu Asp Ala Glu Lys Leu 
        35                  40                  45              


Val Gly Arg Val Asn Leu Lys Glu Cys Phe Thr Ala Ala Asn Leu Ile 
    50                  55                  60                  


His Ser Ser Asp Pro Asp Phe Gln Ile Leu Glu Asp Gly Ser Val Tyr 
65                  70                  75                  80  


Thr Thr Asn Thr Ile Leu Leu Ser Ser Glu Lys Arg Ser Phe Thr Ile 
                85                  90                  95      


Leu Leu Ser Asn Thr Glu Asn Gln Glu Lys Lys Lys Ile Phe Val Phe 
            100                 105                 110         


Leu Glu His Gln Thr Lys Val Leu Lys Lys Arg His Thr Lys Glu Lys 
        115                 120                 125             


Val Leu Arg Arg Ala Lys Arg Arg Trp Ala Pro Ile Pro Cys Ser Met 
    130                 135                 140                 


Leu Glu Asn Ser Leu Gly Pro Phe Pro Leu Phe Leu Gln Gln Val Gln 
145                 150                 155                 160 


Ser Asp Thr Ala Gln Asn Tyr Thr Ile Tyr Tyr Ser Ile Arg Gly Pro 
                165                 170                 175     


Gly Val Asp Gln Glu Pro Arg Asn Leu Phe Tyr Val Glu Arg Asp Thr 
            180                 185                 190         


Gly Asn Leu Tyr Cys Thr Arg Pro Val Asp Arg Glu Gln Tyr Glu Ser 
        195                 200                 205             


Phe Glu Ile Ile Ala Phe Ala Thr Thr Pro Asp Gly Tyr Thr Pro Glu 
    210                 215                 220                 


Leu Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Glu Asn Asp Asn Tyr 
225                 230                 235                 240 


Pro Ile Phe Thr Glu Glu Thr Tyr Thr Phe Thr Ile Phe Glu Asn Cys 
                245                 250                 255     


Arg Val Gly Thr Thr Val Gly Gln Val Cys Ala Thr Asp Lys Asp Glu 
            260                 265                 270         


Pro Asp Thr Met His Thr Arg Leu Lys Tyr Ser Ile Ile Gly Gln Val 
        275                 280                 285             


Pro Pro Ser Pro Thr Leu Phe Ser Met His Pro Thr Thr Gly Val Ile 
    290                 295                 300                 


Thr Thr Thr Ser Ser Gln Leu Asp Arg Glu Leu Ile Asp Lys Tyr Gln 
305                 310                 315                 320 


Leu Lys Ile Lys Val Gln Asp Met Asp Gly Gln Tyr Phe Gly Leu Gln 
                325                 330                 335     


Thr Thr Ser Thr Cys Ile Ile Asn Ile Asp Asp Val Asn Asp His Leu 
            340                 345                 350         


Pro Thr Phe Thr Arg Thr Ser Tyr Val Thr Ser Val Glu Glu Asn Thr 
        355                 360                 365             


Val Asp Val Glu Ile Leu Arg Val Thr Val Glu Asp Lys Asp Leu Val 
    370                 375                 380                 


Asn Thr Ala Asn Trp Arg Ala Asn Tyr Thr Ile Leu Lys Gly Asn Glu 
385                 390                 395                 400 


Asn Gly Asn Phe Lys Ile Val Thr Asp Ala Lys Thr Asn Glu Gly Val 
                405                 410                 415     


Leu Cys Val Val Lys Pro Leu Asn Tyr Glu Glu Lys Gln Gln Met Ile 
            420                 425                 430         


Leu Gln Ile Gly Val Val Asn Glu Ala Pro Phe Ser Arg Glu Ala Ser 
        435                 440                 445             


Pro Arg Ser Ala Met Ser Thr Ala Thr Val Thr Val Asn Val Glu Asp 
    450                 455                 460                 


Gln Asp Glu Gly Pro Glu Cys Asn Pro Pro Ile Gln Thr Val Arg Met 
465                 470                 475                 480 


Lys Glu Asn Ala Glu Val Gly Thr Thr Ser Asn Gly Tyr Lys Ala Tyr 
                485                 490                 495     


Asp Pro Glu Thr Arg Ser Ser Ser Gly Ile Arg Tyr Lys Lys Leu Thr 
            500                 505                 510         


Asp Pro Thr Gly Trp Val Thr Ile Asp Glu Asn Thr Gly Ser Ile Lys 
        515                 520                 525             


Val Phe Arg Ser Leu Asp Arg Glu Ala Glu Thr Ile Lys Asn Gly Ile 
    530                 535                 540                 


Tyr Asn Ile Thr Val Leu Ala Ser Asp Gln Gly Gly Arg Thr Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Gly Ile Ile Leu Gln Asp Val Asn Asp Asn Ser Pro Phe 
                565                 570                 575     


Ile Pro Lys Lys Thr Val Ile Ile Cys Lys Pro Thr Met Ser Ser Ala 
            580                 585                 590         


Glu Ile Val Ala Val Asp Pro Asp Glu Pro Ile His Gly Pro Pro Phe 
        595                 600                 605             


Asp Phe Ser Leu Glu Ser Ser Thr Ser Glu Val Gln Arg Met Trp Arg 
    610                 615                 620                 


Leu Lys Ala Ile Asn Asp Thr Ala Ala Arg Leu Ser Tyr Gln Asn Asp 
625                 630                 635                 640 


Pro Pro Phe Gly Ser Tyr Val Val Pro Ile Thr Val Arg Asp Arg Leu 
                645                 650                 655     


Gly Met Ser Ser Val Thr Ser Leu Asp Val Thr Leu Cys Asp Cys Ile 
            660                 665                 670         


Thr Glu Asn Asp Cys Thr His Arg Val Asp Pro Arg Ile Gly Gly Gly 
        675                 680                 685             


Gly Val Gln Leu Gly Lys Trp Ala Ile Leu Ala Ile Leu Leu Gly Ile 
    690                 695                 700                 


Ala Leu Leu Phe Cys Ile Leu Phe Thr Leu Val Cys Gly Ala Ser Gly 
705                 710                 715                 720 


Thr Ser Lys Gln Pro Lys Val Ile Pro Asp Asp Leu Ala Gln Gln Asn 
                725                 730                 735     


Leu Ile Val Ser Asn Thr Glu Ala Pro Gly Asp Asp Lys Val Tyr Ser 
            740                 745                 750         


Ala Asn Gly Phe Thr Thr Gln Thr Val Gly Ala Ser Ala Gln Gly Val 
        755                 760                 765             


Cys Gly Thr Val Gly Ser Gly Ile Lys Asn Gly Gly Gln Glu Thr Ile 
    770                 775                 780                 


Glu Met Val Lys Gly Gly His Gln Thr Ser Glu Ser Cys Arg Gly Ala 
785                 790                 795                 800 


Gly His His His Thr Leu Asp Ser Cys Arg Gly Gly His Thr Glu Val 
                805                 810                 815     


Asp Asn Cys Arg Tyr Thr Tyr Ser Glu Trp His Ser Phe Thr Gln Pro 
            820                 825                 830         


Arg Leu Gly Glu Glu Ser Ile Arg Gly His Thr Leu Ile Lys Asn 
        835                 840                 845         


<210>  88
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Leu Ala Ser Ala Ala Pro Gly Ser Ile Phe Cys Lys Gln Leu 
1               5                   10                  15      


Leu Phe Ser Leu Leu Val Leu Thr Leu Leu Cys Asp Ala Cys Gln Lys 
            20                  25                  30          


Val Tyr Leu Arg Val Pro Ser His Leu Gln Ala Glu Thr Leu Val Gly 
        35                  40                  45              


Lys Val Asn Leu Glu Glu Cys Leu Lys Ser Ala Ser Leu Ile Arg Ser 
    50                  55                  60                  


Ser Asp Pro Ala Phe Arg Ile Leu Glu Asp Gly Ser Ile Tyr Thr Thr 
65                  70                  75                  80  


His Asp Leu Ile Leu Ser Ser Glu Arg Lys Ser Phe Ser Ile Phe Leu 
                85                  90                  95      


Ser Asp Gly Gln Arg Arg Glu Gln Gln Glu Ile Lys Val Val Leu Ser 
            100                 105                 110         


Ala Arg Glu Asn Lys Ser Pro Lys Lys Arg His Thr Lys Asp Thr Ala 
        115                 120                 125             


Leu Lys Arg Ser Lys Arg Arg Trp Ala Pro Ile Pro Ala Ser Leu Met 
    130                 135                 140                 


Glu Asn Ser Leu Gly Pro Phe Pro Gln His Val Gln Gln Ile Gln Ser 
145                 150                 155                 160 


Asp Ala Ala Gln Asn Tyr Thr Ile Phe Tyr Ser Ile Ser Gly Pro Gly 
                165                 170                 175     


Val Asp Lys Glu Pro Phe Asn Leu Phe Tyr Ile Glu Lys Asp Thr Gly 
            180                 185                 190         


Asp Ile Phe Cys Thr Arg Ser Ile Asp Arg Glu Lys Tyr Glu Gln Phe 
        195                 200                 205             


Ala Leu Tyr Gly Tyr Ala Thr Thr Ala Asp Gly Tyr Ala Pro Glu Tyr 
    210                 215                 220                 


Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Asp Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Tyr Phe Glu His Arg Val Thr Ile Phe Thr Val Pro Glu Asn Cys Arg 
                245                 250                 255     


Ser Gly Thr Ser Val Gly Lys Val Thr Ala Thr Asp Leu Asp Glu Pro 
            260                 265                 270         


Asp Thr Leu His Thr Arg Leu Lys Tyr Lys Ile Leu Gln Gln Ile Pro 
        275                 280                 285             


Asp His Pro Lys His Phe Ser Ile His Pro Asp Thr Gly Val Ile Thr 
    290                 295                 300                 


Thr Thr Thr Pro Phe Leu Asp Arg Glu Lys Cys Asp Thr Tyr Gln Leu 
305                 310                 315                 320 


Ile Met Glu Val Arg Asp Met Gly Gly Gln Pro Phe Gly Leu Phe Asn 
                325                 330                 335     


Thr Gly Thr Ile Thr Ile Ser Leu Glu Asp Glu Asn Asp Asn Pro Pro 
            340                 345                 350         


Ser Phe Thr Glu Thr Ser Tyr Val Thr Glu Val Glu Glu Asn Arg Ile 
        355                 360                 365             


Asp Val Glu Ile Leu Arg Met Lys Val Gln Asp Gln Asp Leu Pro Asn 
    370                 375                 380                 


Thr Pro His Ser Lys Ala Val Tyr Lys Ile Leu Gln Gly Asn Glu Asn 
385                 390                 395                 400 


Gly Asn Phe Ile Ile Ser Thr Asp Pro Asn Thr Asn Glu Gly Val Leu 
                405                 410                 415     


Cys Val Val Lys Pro Leu Asn Tyr Glu Val Asn Arg Gln Val Ile Leu 
            420                 425                 430         


Gln Val Gly Val Ile Asn Glu Ala Gln Phe Ser Lys Ala Ala Ser Ser 
        435                 440                 445             


Gln Thr Pro Thr Met Cys Thr Thr Thr Val Thr Val Lys Ile Ile Asp 
    450                 455                 460                 


Ser Asp Glu Gly Pro Glu Cys His Pro Pro Val Lys Val Ile Gln Ser 
465                 470                 475                 480 


Gln Asp Gly Phe Pro Ala Gly Gln Glu Leu Leu Gly Tyr Lys Ala Leu 
                485                 490                 495     


Asp Pro Glu Ile Ser Ser Gly Glu Gly Leu Arg Tyr Gln Lys Leu Gly 
            500                 505                 510         


Asp Glu Asp Asn Trp Phe Glu Ile Asn Gln His Thr Gly Asp Leu Arg 
        515                 520                 525             


Thr Leu Lys Val Leu Asp Arg Glu Ser Lys Phe Val Lys Asn Asn Gln 
    530                 535                 540                 


Tyr Asn Ile Ser Val Val Ala Val Asp Ala Val Gly Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Val Val His Leu Asp Asp Tyr Asn Asp His Ala Pro Gln 
                565                 570                 575     


Ile Asp Lys Glu Val Thr Ile Cys Gln Asn Asn Glu Asp Phe Ala Val 
            580                 585                 590         


Leu Lys Pro Val Asp Pro Asp Gly Pro Glu Asn Gly Pro Pro Phe Gln 
        595                 600                 605             


Phe Phe Leu Asp Asn Ser Ala Ser Lys Asn Trp Asn Ile Glu Glu Lys 
    610                 615                 620                 


Asp Gly Lys Thr Ala Ile Leu Arg Gln Arg Gln Asn Leu Asp Tyr Asn 
625                 630                 635                 640 


Tyr Tyr Ser Val Pro Ile Gln Ile Lys Asp Arg His Gly Leu Val Ala 
                645                 650                 655     


Thr His Met Leu Thr Val Arg Val Cys Asp Cys Ser Thr Pro Ser Glu 
            660                 665                 670         


Cys Arg Met Lys Asp Lys Ser Thr Arg Asp Val Arg Pro Asn Val Ile 
        675                 680                 685             


Leu Gly Arg Trp Ala Ile Leu Ala Met Val Leu Gly Ser Val Leu Leu 
    690                 695                 700                 


Leu Cys Ile Leu Phe Thr Cys Phe Cys Val Thr Ala Lys Arg Thr Val 
705                 710                 715                 720 


Lys Lys Cys Phe Pro Glu Asp Ile Ala Gln Gln Asn Leu Ile Val Ser 
                725                 730                 735     


Asn Thr Glu Gly Pro Gly Glu Glu Val Thr Glu Ala Asn Ile Arg Leu 
            740                 745                 750         


Pro Met Gln Thr Ser Asn Ile Cys Asp Thr Ser Met Ser Val Gly Thr 
        755                 760                 765             


Val Gly Gly Gln Gly Ile Lys Thr Gln Gln Ser Phe Glu Met Val Lys 
    770                 775                 780                 


Gly Gly Tyr Thr Leu Asp Ser Asn Lys Gly Gly Gly His Gln Thr Leu 
785                 790                 795                 800 


Glu Ser Val Lys Gly Val Gly Gln Gly Asp Thr Gly Arg Tyr Ala Tyr 
                805                 810                 815     


Thr Asp Trp Gln Ser Phe Thr Gln Pro Arg Leu Gly Glu Lys Val Tyr 
            820                 825                 830         


Leu Cys Gly Gln Asp Glu Glu His Lys His Cys Glu Asp Tyr Val Cys 
        835                 840                 845             


Ser Tyr Asn Tyr Glu Gly Lys Gly Ser Leu Ala Gly Ser Val Gly Cys 
    850                 855                 860                 


Cys Ser Asp Arg Gln Glu Glu Glu Gly Leu Glu Phe Leu Asp His Leu 
865                 870                 875                 880 


Glu Pro Lys Phe Arg Thr Leu Ala Lys Thr Cys Ile Lys Lys 
                885                 890                 


<210>  89
<211>  840
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ala Leu Ala Ser Ala Ala Pro Gly Ser Ile Phe Cys Lys Gln Leu 
1               5                   10                  15      


Leu Phe Ser Leu Leu Val Leu Thr Leu Leu Cys Asp Ala Cys Gln Lys 
            20                  25                  30          


Val Tyr Leu Arg Val Pro Ser His Leu Gln Ala Glu Thr Leu Val Gly 
        35                  40                  45              


Lys Val Asn Leu Glu Glu Cys Leu Lys Ser Ala Ser Leu Ile Arg Ser 
    50                  55                  60                  


Ser Asp Pro Ala Phe Arg Ile Leu Glu Asp Gly Ser Ile Tyr Thr Thr 
65                  70                  75                  80  


His Asp Leu Ile Leu Ser Ser Glu Arg Lys Ser Phe Ser Ile Phe Leu 
                85                  90                  95      


Ser Asp Gly Gln Arg Arg Glu Gln Gln Glu Ile Lys Val Val Leu Ser 
            100                 105                 110         


Ala Arg Glu Asn Lys Ser Pro Lys Lys Arg His Thr Lys Asp Thr Ala 
        115                 120                 125             


Leu Lys Arg Ser Lys Arg Arg Trp Ala Pro Ile Pro Ala Ser Leu Met 
    130                 135                 140                 


Glu Asn Ser Leu Gly Pro Phe Pro Gln His Val Gln Gln Ile Gln Ser 
145                 150                 155                 160 


Asp Ala Ala Gln Asn Tyr Thr Ile Phe Tyr Ser Ile Ser Gly Pro Gly 
                165                 170                 175     


Val Asp Lys Glu Pro Phe Asn Leu Phe Tyr Ile Glu Lys Asp Thr Gly 
            180                 185                 190         


Asp Ile Phe Cys Thr Arg Ser Ile Asp Arg Glu Lys Tyr Glu Gln Phe 
        195                 200                 205             


Ala Leu Tyr Gly Tyr Ala Thr Thr Ala Asp Gly Tyr Ala Pro Glu Tyr 
    210                 215                 220                 


Pro Leu Pro Leu Ile Ile Lys Ile Glu Asp Asp Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Tyr Phe Glu His Arg Val Thr Ile Phe Thr Val Pro Glu Asn Cys Arg 
                245                 250                 255     


Ser Gly Thr Ser Val Gly Lys Val Thr Ala Thr Asp Leu Asp Glu Pro 
            260                 265                 270         


Asp Thr Leu His Thr Arg Leu Lys Tyr Lys Ile Leu Gln Gln Ile Pro 
        275                 280                 285             


Asp His Pro Lys His Phe Ser Ile His Pro Asp Thr Gly Val Ile Thr 
    290                 295                 300                 


Thr Thr Thr Pro Phe Leu Asp Arg Glu Lys Cys Asp Thr Tyr Gln Leu 
305                 310                 315                 320 


Ile Met Glu Val Arg Asp Met Gly Gly Gln Pro Phe Gly Leu Phe Asn 
                325                 330                 335     


Thr Gly Thr Ile Thr Ile Ser Leu Glu Asp Glu Asn Asp Asn Pro Pro 
            340                 345                 350         


Ser Phe Thr Glu Thr Ser Tyr Val Thr Glu Val Glu Glu Asn Arg Ile 
        355                 360                 365             


Asp Val Glu Ile Leu Arg Met Lys Val Gln Asp Gln Asp Leu Pro Asn 
    370                 375                 380                 


Thr Pro His Ser Lys Ala Val Tyr Lys Ile Leu Gln Gly Asn Glu Asn 
385                 390                 395                 400 


Gly Asn Phe Ile Ile Ser Thr Asp Pro Asn Thr Asn Glu Gly Val Leu 
                405                 410                 415     


Cys Val Val Lys Pro Leu Asn Tyr Glu Val Asn Arg Gln Val Ile Leu 
            420                 425                 430         


Gln Val Gly Val Ile Asn Glu Ala Gln Phe Ser Lys Ala Ala Ser Ser 
        435                 440                 445             


Gln Thr Pro Thr Met Cys Thr Thr Thr Val Thr Val Lys Ile Ile Asp 
    450                 455                 460                 


Ser Asp Glu Gly Pro Glu Cys His Pro Pro Val Lys Val Ile Gln Ser 
465                 470                 475                 480 


Gln Asp Gly Phe Pro Ala Gly Gln Glu Leu Leu Gly Tyr Lys Ala Leu 
                485                 490                 495     


Asp Pro Glu Ile Ser Ser Gly Glu Gly Leu Arg Tyr Gln Lys Leu Gly 
            500                 505                 510         


Asp Glu Asp Asn Trp Phe Glu Ile Asn Gln His Thr Gly Asp Leu Arg 
        515                 520                 525             


Thr Leu Lys Val Leu Asp Arg Glu Ser Lys Phe Val Lys Asn Asn Gln 
    530                 535                 540                 


Tyr Asn Ile Ser Val Val Ala Val Asp Ala Val Gly Arg Ser Cys Thr 
545                 550                 555                 560 


Gly Thr Leu Val Val His Leu Asp Asp Tyr Asn Asp His Ala Pro Gln 
                565                 570                 575     


Ile Asp Lys Glu Val Thr Ile Cys Gln Asn Asn Glu Asp Phe Ala Val 
            580                 585                 590         


Leu Lys Pro Val Asp Pro Asp Gly Pro Glu Asn Gly Pro Pro Phe Gln 
        595                 600                 605             


Phe Phe Leu Asp Asn Ser Ala Ser Lys Asn Trp Asn Ile Glu Glu Lys 
    610                 615                 620                 


Asp Gly Lys Thr Ala Ile Leu Arg Gln Arg Gln Asn Leu Asp Tyr Asn 
625                 630                 635                 640 


Tyr Tyr Ser Val Pro Ile Gln Ile Lys Asp Arg His Gly Leu Val Ala 
                645                 650                 655     


Thr His Met Leu Thr Val Arg Val Cys Asp Cys Ser Thr Pro Ser Glu 
            660                 665                 670         


Cys Arg Met Lys Asp Lys Ser Thr Arg Asp Val Arg Pro Asn Val Ile 
        675                 680                 685             


Leu Gly Arg Trp Ala Ile Leu Ala Met Val Leu Gly Ser Val Leu Leu 
    690                 695                 700                 


Leu Cys Ile Leu Phe Thr Cys Phe Cys Val Thr Ala Lys Arg Thr Val 
705                 710                 715                 720 


Lys Lys Cys Phe Pro Glu Asp Ile Ala Gln Gln Asn Leu Ile Val Ser 
                725                 730                 735     


Asn Thr Glu Gly Pro Gly Glu Glu Val Thr Glu Ala Asn Ile Arg Leu 
            740                 745                 750         


Pro Met Gln Thr Ser Asn Ile Cys Asp Thr Ser Met Ser Val Gly Thr 
        755                 760                 765             


Val Gly Gly Gln Gly Ile Lys Thr Gln Gln Ser Phe Glu Met Val Lys 
    770                 775                 780                 


Gly Gly Tyr Thr Leu Asp Ser Asn Lys Gly Gly Gly His Gln Thr Leu 
785                 790                 795                 800 


Glu Ser Val Lys Gly Val Gly Gln Gly Asp Thr Gly Arg Tyr Ala Tyr 
                805                 810                 815     


Thr Asp Trp Gln Ser Phe Thr Gln Pro Arg Leu Gly Glu Glu Ser Ile 
            820                 825                 830         


Arg Gly His Thr Leu Ile Lys Asn 
        835                 840 


<210>  90
<211>  1073
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp 
            260                 265                 270         


Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala 
        275                 280                 285             


Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu 
    290                 295                 300                 


His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val 
305                 310                 315                 320 


Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly 
                325                 330                 335     


Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr 
            340                 345                 350         


Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg 
        355                 360                 365             


Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile 
    370                 375                 380                 


Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro 
385                 390                 395                 400 


Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly 
                405                 410                 415     


Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe 
            420                 425                 430         


Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro 
        435                 440                 445             


Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser 
    450                 455                 460                 


Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg 
465                 470                 475                 480 


Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys 
                485                 490                 495     


Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr 
            500                 505                 510         


Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg 
        515                 520                 525             


Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser 
    530                 535                 540                 


Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys 
545                 550                 555                 560 


Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys 
                565                 570                 575     


Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser 
            580                 585                 590         


Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn 
        595                 600                 605             


Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu 
    610                 615                 620                 


Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr 
625                 630                 635                 640 


Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro 
                645                 650                 655     


Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile 
            660                 665                 670         


Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro 
        675                 680                 685             


Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe 
    690                 695                 700                 


Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro 
705                 710                 715                 720 


Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp 
                725                 730                 735     


Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr 
            740                 745                 750         


Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp 
        755                 760                 765             


Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro 
    770                 775                 780                 


Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser 
785                 790                 795                 800 


Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly 
                805                 810                 815     


Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr 
            820                 825                 830         


Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr 
        835                 840                 845             


Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp 
    850                 855                 860                 


Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr 
865                 870                 875                 880 


Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His 
                885                 890                 895     


Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn 
            900                 905                 910         


Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys 
        915                 920                 925             


Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu 
    930                 935                 940                 


Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr 
945                 950                 955                 960 


Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg 
                965                 970                 975     


Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn 
            980                 985                 990         


Ala Gly Thr Gln Val Arg Val Thr  Val Phe Pro Ser Lys  Thr Val Ala 
        995                 1000                 1005             


Gln Tyr  Ser Gly Val Pro Trp  Trp Ile Ile Leu Val  Ala Ile Leu 
    1010                 1015                 1020             


Ala Gly  Ile Leu Met Leu Ala  Leu Leu Val Phe Ile  Leu Trp Lys 
    1025                 1030                 1035             


Cys Gly  Phe Phe Lys Arg Asn  Lys Lys Asp His Tyr  Asp Ala Thr 
    1040                 1045                 1050             


Tyr His  Lys Ala Glu Ile His  Ala Gln Pro Ser Asp  Lys Glu Arg 
    1055                 1060                 1065             


Leu Thr  Ser Asp Ala 
    1070             


<210>  91
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp 
            260                 265                 270         


Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala 
        275                 280                 285             


Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu 
    290                 295                 300                 


His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val 
305                 310                 315                 320 


Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly 
                325                 330                 335     


Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr 
            340                 345                 350         


Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg 
        355                 360                 365             


Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile 
    370                 375                 380                 


Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro 
385                 390                 395                 400 


Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly 
                405                 410                 415     


Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe 
            420                 425                 430         


Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro 
        435                 440                 445             


Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser 
    450                 455                 460                 


Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg 
465                 470                 475                 480 


Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys 
                485                 490                 495     


Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr 
            500                 505                 510         


Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg 
        515                 520                 525             


Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser 
    530                 535                 540                 


Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys 
545                 550                 555                 560 


Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys 
                565                 570                 575     


Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser 
            580                 585                 590         


Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn 
        595                 600                 605             


Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu 
    610                 615                 620                 


Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr 
625                 630                 635                 640 


Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro 
                645                 650                 655     


Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile 
            660                 665                 670         


Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro 
        675                 680                 685             


Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe 
    690                 695                 700                 


Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro 
705                 710                 715                 720 


Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp 
                725                 730                 735     


Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr 
            740                 745                 750         


Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp 
        755                 760                 765             


Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro 
    770                 775                 780                 


Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser 
785                 790                 795                 800 


Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly 
                805                 810                 815     


Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr 
            820                 825                 830         


Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr 
        835                 840                 845             


Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp 
    850                 855                 860                 


Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr 
865                 870                 875                 880 


Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His 
                885                 890                 895     


Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn 
            900                 905                 910         


Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys 
        915                 920                 925             


Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu 
    930                 935                 940                 


Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr 
945                 950                 955                 960 


Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg 
                965                 970                 975     


Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn 
            980                 985                 990         


Ala Gly Thr Gln Val Arg Val Thr  Val Phe Pro Ser Lys  Thr Val Ala 
        995                 1000                 1005             


Gln Tyr  Ser Gly Val Pro Trp  Trp Ile Ile Leu Val  Ala Ile Leu 
    1010                 1015                 1020             


Ala Gly  Ile Leu Met Leu Ala  Leu Leu Val Phe Ile  Leu Trp Lys 
    1025                 1030                 1035             


Cys Gly  Phe Phe Lys Arg Ser  Arg Tyr Asp Asp Ser  Val Pro Arg 
    1040                 1045                 1050             


Tyr His  Ala Val Arg Ile Arg  Lys Glu Glu Arg Glu  Ile Lys Asp 
    1055                 1060                 1065             


Glu Lys  Tyr Ile Asp Asn Leu  Glu Lys Lys Gln Trp  Ile Thr Lys 
    1070                 1075                 1080             


Trp Asn  Glu Asn Glu Ser Tyr  Ser 
    1085                 1090     


<210>  92
<211>  1822
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                  25                  30          


Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                  40                  45              


Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                  55                  60                  


Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                  70                  75                  80  


Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                  90                  95      


Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                 105                 110         


Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                 120                 125             


Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                 135                 140                 


Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                 150                 155                 160 


Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                 170                 175     


Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                 185                 190         


Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                 200                 205             


Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                 215                 220                 


Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                 230                 235                 240 


Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                 250                 255     


His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                 265                 270         


Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                 280                 285             


His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                 295                 300                 


Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                 310                 315                 320 


Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                 330                 335     


His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                 345                 350         


Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                 360                 365             


Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                 375                 380                 


Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                 390                 395                 400 


Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                 410                 415     


His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                 425                 430         


Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                 440                 445             


Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                 455                 460                 


Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                 470                 475                 480 


Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                 490                 495     


Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                 505                 510         


Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                 520                 525             


Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                 535                 540                 


Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                 550                 555                 560 


Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                 570                 575     


Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                 585                 590         


Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                 600                 605             


Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                 615                 620                 


Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                 630                 635                 640 


Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                 650                 655     


Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                 665                 670         


Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                 680                 685             


Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                 695                 700                 


Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                 730                 735     


Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                 745                 750         


His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                 760                 765             


Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                 775                 780                 


Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                 790                 795                 800 


Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                 810                 815     


Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                 825                 830         


Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                 840                 845             


Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                 855                 860                 


Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                 870                 875                 880 


His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                 890                 895     


Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                 905                 910         


Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                 920                 925             


Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                 935                 940                 


Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                 950                 955                 960 


Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                 970                 975     


Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                 985                 990         


Ser Phe Glu Gln Pro Glu Phe Ser  Val Ser Arg Gly Asp  Gln Val Ala 
        995                 1000                 1005             


Arg Ile  Pro Val Ile Arg Arg  Val Leu Asp Gly Gly  Lys Ser Gln 
    1010                 1015                 1020             


Val Ser  Tyr Arg Thr Gln Asp  Gly Thr Ala Gln Gly  Asn Arg Asp 
    1025                 1030                 1035             


Tyr Ile  Pro Val Glu Gly Glu  Leu Leu Phe Gln Pro  Gly Glu Ala 
    1040                 1045                 1050             


Trp Lys  Glu Leu Gln Val Lys  Leu Leu Glu Leu Gln  Glu Val Asp 
    1055                 1060                 1065             


Ser Leu  Leu Arg Gly Arg Gln  Val Arg Arg Phe His  Val Gln Leu 
    1070                 1075                 1080             


Ser Asn  Pro Lys Phe Gly Ala  His Leu Gly Gln Pro  His Ser Thr 
    1085                 1090                 1095             


Thr Ile  Ile Ile Arg Asp Pro  Asp Glu Leu Asp Arg  Ser Phe Thr 
    1100                 1105                 1110             


Ser Gln  Met Leu Ser Ser Gln  Pro Pro Pro His Gly  Asp Leu Gly 
    1115                 1120                 1125             


Ala Pro  Gln Asn Pro Asn Ala  Lys Ala Ala Gly Ser  Arg Lys Ile 
    1130                 1135                 1140             


His Phe  Asn Trp Leu Pro Pro  Ser Gly Lys Pro Met  Gly Tyr Arg 
    1145                 1150                 1155             


Val Lys  Tyr Trp Ile Gln Gly  Asp Ser Glu Ser Glu  Ala His Leu 
    1160                 1165                 1170             


Leu Asp  Ser Lys Val Pro Ser  Val Glu Leu Thr Asn  Leu Tyr Pro 
    1175                 1180                 1185             


Tyr Cys  Asp Tyr Glu Met Lys  Val Cys Ala Tyr Gly  Ala Gln Gly 
    1190                 1195                 1200             


Glu Gly  Pro Tyr Ser Ser Leu  Val Ser Cys Arg Thr  His Gln Glu 
    1205                 1210                 1215             


Val Pro  Ser Glu Pro Gly Arg  Leu Ala Phe Asn Val  Val Ser Ser 
    1220                 1225                 1230             


Thr Val  Thr Gln Leu Ser Trp  Ala Glu Pro Ala Glu  Thr Asn Gly 
    1235                 1240                 1245             


Glu Ile  Thr Ala Tyr Glu Val  Cys Tyr Gly Leu Val  Asn Asp Asp 
    1250                 1255                 1260             


Asn Arg  Pro Ile Gly Pro Met  Lys Lys Val Leu Val  Asp Asn Pro 
    1265                 1270                 1275             


Lys Asn  Arg Met Leu Leu Ile  Glu Asn Leu Arg Glu  Ser Gln Pro 
    1280                 1285                 1290             


Tyr Arg  Tyr Thr Val Lys Ala  Arg Asn Gly Ala Gly  Trp Gly Pro 
    1295                 1300                 1305             


Glu Arg  Glu Ala Ile Ile Asn  Leu Ala Thr Gln Pro  Lys Arg Pro 
    1310                 1315                 1320             


Met Ser  Ile Pro Ile Ile Pro  Asp Ile Pro Ile Val  Asp Ala Gln 
    1325                 1330                 1335             


Ser Gly  Glu Asp Tyr Asp Ser  Phe Leu Met Tyr Ser  Asp Asp Val 
    1340                 1345                 1350             


Leu Arg  Ser Pro Ser Gly Ser  Gln Arg Pro Ser Val  Ser Asp Asp 
    1355                 1360                 1365             


Thr Gly  Cys Gly Trp Lys Phe  Glu Pro Leu Leu Gly  Glu Glu Leu 
    1370                 1375                 1380             


Asp Leu  Arg Arg Val Thr Trp  Arg Leu Pro Pro Glu  Leu Ile Pro 
    1385                 1390                 1395             


Arg Leu  Ser Ala Ser Ser Gly  Arg Ser Ser Asp Ala  Glu Ala Pro 
    1400                 1405                 1410             


His Gly  Pro Pro Asp Asp Gly  Gly Ala Gly Gly Lys  Gly Gly Ser 
    1415                 1420                 1425             


Leu Pro  Arg Ser Ala Thr Pro  Gly Pro Pro Gly Glu  His Leu Val 
    1430                 1435                 1440             


Asn Gly  Arg Met Asp Phe Ala  Phe Pro Gly Ser Thr  Asn Ser Leu 
    1445                 1450                 1455             


His Arg  Met Thr Thr Thr Ser  Ala Ala Ala Tyr Gly  Thr His Leu 
    1460                 1465                 1470             


Ser Pro  His Val Pro His Arg  Val Leu Ser Thr Ser  Ser Thr Leu 
    1475                 1480                 1485             


Thr Arg  Asp Tyr Asn Ser Leu  Thr Arg Ser Glu His  Ser His Ser 
    1490                 1495                 1500             


Thr Thr  Leu Pro Arg Asp Tyr  Ser Thr Leu Thr Ser  Val Ser Ser 
    1505                 1510                 1515             


His Asp  Ser Arg Leu Thr Ala  Gly Val Pro Asp Thr  Pro Thr Arg 
    1520                 1525                 1530             


Leu Val  Phe Ser Ala Leu Gly  Pro Thr Ser Leu Arg  Val Ser Trp 
    1535                 1540                 1545             


Gln Glu  Pro Arg Cys Glu Arg  Pro Leu Gln Gly Tyr  Ser Val Glu 
    1550                 1555                 1560             


Tyr Gln  Leu Leu Asn Gly Gly  Glu Leu His Arg Leu  Asn Ile Pro 
    1565                 1570                 1575             


Asn Pro  Ala Gln Thr Ser Val  Val Val Glu Asp Leu  Leu Pro Asn 
    1580                 1585                 1590             


His Ser  Tyr Val Phe Arg Val  Arg Ala Gln Ser Gln  Glu Gly Trp 
    1595                 1600                 1605             


Gly Arg  Glu Arg Glu Gly Val  Ile Thr Ile Glu Ser  Gln Val His 
    1610                 1615                 1620             


Pro Gln  Ser Pro Leu Cys Pro  Leu Pro Gly Ser Ala  Phe Thr Leu 
    1625                 1630                 1635             


Ser Thr  Pro Ser Ala Pro Gly  Pro Leu Val Phe Thr  Ala Leu Ser 
    1640                 1645                 1650             


Pro Asp  Ser Leu Gln Leu Ser  Trp Glu Arg Pro Arg  Arg Pro Asn 
    1655                 1660                 1665             


Gly Asp  Ile Val Gly Tyr Leu  Val Thr Cys Glu Met  Ala Gln Gly 
    1670                 1675                 1680             


Gly Gly  Pro Ala Thr Ala Phe  Arg Val Asp Gly Asp  Ser Pro Glu 
    1685                 1690                 1695             


Ser Arg  Leu Thr Val Pro Gly  Leu Ser Glu Asn Val  Pro Tyr Lys 
    1700                 1705                 1710             


Phe Lys  Val Gln Ala Arg Thr  Thr Glu Gly Phe Gly  Pro Glu Arg 
    1715                 1720                 1725             


Glu Gly  Ile Ile Thr Ile Glu  Ser Gln Asp Gly Gly  Pro Phe Pro 
    1730                 1735                 1740             


Gln Leu  Gly Ser Arg Ala Gly  Leu Phe Gln His Pro  Leu Gln Ser 
    1745                 1750                 1755             


Glu Tyr  Ser Ser Ile Thr Thr  Thr His Thr Ser Ala  Thr Glu Pro 
    1760                 1765                 1770             


Phe Leu  Val Asp Gly Leu Thr  Leu Gly Ala Gln His  Leu Glu Ala 
    1775                 1780                 1785             


Gly Gly  Ser Leu Thr Arg His  Val Thr Gln Glu Phe  Val Ser Arg 
    1790                 1795                 1800             


Thr Leu  Thr Thr Ser Gly Thr  Leu Ser Thr His Met  Asp Gln Gln 
    1805                 1810                 1815             


Phe Phe  Gln Thr 
    1820         


<210>  93
<211>  1805
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                  25                  30          


Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                  40                  45              


Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                  55                  60                  


Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                  70                  75                  80  


Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                  90                  95      


Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                 105                 110         


Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                 120                 125             


Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                 135                 140                 


Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                 150                 155                 160 


Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                 170                 175     


Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                 185                 190         


Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                 200                 205             


Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                 215                 220                 


Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                 230                 235                 240 


Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                 250                 255     


His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                 265                 270         


Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                 280                 285             


His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                 295                 300                 


Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                 310                 315                 320 


Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                 330                 335     


His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                 345                 350         


Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                 360                 365             


Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                 375                 380                 


Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                 390                 395                 400 


Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                 410                 415     


His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                 425                 430         


Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                 440                 445             


Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                 455                 460                 


Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                 470                 475                 480 


Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                 490                 495     


Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                 505                 510         


Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                 520                 525             


Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                 535                 540                 


Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                 550                 555                 560 


Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                 570                 575     


Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                 585                 590         


Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                 600                 605             


Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                 615                 620                 


Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                 630                 635                 640 


Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                 650                 655     


Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                 665                 670         


Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                 680                 685             


Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                 695                 700                 


Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                 730                 735     


Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                 745                 750         


His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                 760                 765             


Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                 775                 780                 


Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                 790                 795                 800 


Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                 810                 815     


Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                 825                 830         


Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                 840                 845             


Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                 855                 860                 


Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                 870                 875                 880 


His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                 890                 895     


Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                 905                 910         


Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                 920                 925             


Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                 935                 940                 


Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                 950                 955                 960 


Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                 970                 975     


Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                 985                 990         


Ser Phe Glu Gln Pro Glu Phe Ser  Val Ser Arg Gly Asp  Gln Val Ala 
        995                 1000                 1005             


Arg Ile  Pro Val Ile Arg Arg  Val Leu Asp Gly Gly  Lys Ser Gln 
    1010                 1015                 1020             


Val Ser  Tyr Arg Thr Gln Asp  Gly Thr Ala Gln Gly  Asn Arg Asp 
    1025                 1030                 1035             


Tyr Ile  Pro Val Glu Gly Glu  Leu Leu Phe Gln Pro  Gly Glu Ala 
    1040                 1045                 1050             


Trp Lys  Glu Leu Gln Val Lys  Leu Leu Glu Leu Gln  Glu Val Asp 
    1055                 1060                 1065             


Ser Leu  Leu Arg Gly Arg Gln  Val Arg Arg Phe His  Val Gln Leu 
    1070                 1075                 1080             


Ser Asn  Pro Lys Phe Gly Ala  His Leu Gly Gln Pro  His Ser Thr 
    1085                 1090                 1095             


Thr Ile  Ile Ile Arg Asp Pro  Asp Glu Leu Asp Arg  Ser Phe Thr 
    1100                 1105                 1110             


Ser Gln  Met Leu Ser Ser Gln  Pro Pro Pro His Gly  Asp Leu Gly 
    1115                 1120                 1125             


Ala Pro  Gln Asn Pro Asn Ala  Lys Ala Ala Gly Ser  Arg Lys Ile 
    1130                 1135                 1140             


His Phe  Asn Trp Leu Pro Pro  Ser Gly Lys Pro Met  Gly Tyr Arg 
    1145                 1150                 1155             


Val Lys  Tyr Trp Ile Gln Gly  Asp Ser Glu Ser Glu  Ala His Leu 
    1160                 1165                 1170             


Leu Asp  Ser Lys Val Pro Ser  Val Glu Leu Thr Asn  Leu Tyr Pro 
    1175                 1180                 1185             


Tyr Cys  Asp Tyr Glu Met Lys  Val Cys Ala Tyr Gly  Ala Gln Gly 
    1190                 1195                 1200             


Glu Gly  Pro Tyr Ser Ser Leu  Val Ser Cys Arg Thr  His Gln Glu 
    1205                 1210                 1215             


Val Pro  Ser Glu Pro Gly Arg  Leu Ala Phe Asn Val  Val Ser Ser 
    1220                 1225                 1230             


Thr Val  Thr Gln Leu Ser Trp  Ala Glu Pro Ala Glu  Thr Asn Gly 
    1235                 1240                 1245             


Glu Ile  Thr Ala Tyr Glu Val  Cys Tyr Gly Leu Val  Asn Asp Asp 
    1250                 1255                 1260             


Asn Arg  Pro Ile Gly Pro Met  Lys Lys Val Leu Val  Asp Asn Pro 
    1265                 1270                 1275             


Lys Asn  Arg Met Leu Leu Ile  Glu Asn Leu Arg Glu  Ser Gln Pro 
    1280                 1285                 1290             


Tyr Arg  Tyr Thr Val Lys Ala  Arg Asn Gly Ala Gly  Trp Gly Pro 
    1295                 1300                 1305             


Glu Arg  Glu Ala Ile Ile Asn  Leu Ala Thr Gln Pro  Lys Arg Pro 
    1310                 1315                 1320             


Met Ser  Ile Pro Ile Ile Pro  Asp Ile Pro Ile Val  Asp Ala Gln 
    1325                 1330                 1335             


Ser Gly  Glu Asp Tyr Asp Ser  Phe Leu Met Tyr Ser  Asp Asp Val 
    1340                 1345                 1350             


Leu Arg  Ser Pro Ser Gly Ser  Gln Arg Pro Ser Val  Ser Asp Asp 
    1355                 1360                 1365             


Thr Glu  His Leu Val Asn Gly  Arg Met Asp Phe Ala  Phe Pro Gly 
    1370                 1375                 1380             


Ser Thr  Asn Ser Leu His Arg  Met Thr Thr Thr Ser  Ala Ala Ala 
    1385                 1390                 1395             


Tyr Gly  Thr His Leu Ser Pro  His Val Pro His Arg  Val Leu Ser 
    1400                 1405                 1410             


Thr Ser  Ser Thr Leu Thr Arg  Asp Tyr Asn Ser Leu  Thr Arg Ser 
    1415                 1420                 1425             


Glu His  Ser His Ser Thr Thr  Leu Pro Arg Asp Tyr  Ser Thr Leu 
    1430                 1435                 1440             


Thr Ser  Val Ser Ser His Gly  Leu Pro Pro Ile Trp  Glu His Gly 
    1445                 1450                 1455             


Arg Ser  Arg Leu Pro Leu Ser  Trp Ala Leu Gly Ser  Arg Ser Arg 
    1460                 1465                 1470             


Ala Gln  Met Lys Gly Phe Pro  Pro Ser Arg Gly Pro  Arg Asp Ser 
    1475                 1480                 1485             


Ile Ile  Leu Ala Gly Arg Pro  Ala Ala Pro Ser Trp  Gly Pro Asp 
    1490                 1495                 1500             


Ser Arg  Leu Thr Ala Gly Val  Pro Asp Thr Pro Thr  Arg Leu Val 
    1505                 1510                 1515             


Phe Ser  Ala Leu Gly Pro Thr  Ser Leu Arg Val Ser  Trp Gln Glu 
    1520                 1525                 1530             


Pro Arg  Cys Glu Arg Pro Leu  Gln Gly Tyr Ser Val  Glu Tyr Gln 
    1535                 1540                 1545             


Leu Leu  Asn Gly Gly Glu Leu  His Arg Leu Asn Ile  Pro Asn Pro 
    1550                 1555                 1560             


Ala Gln  Thr Ser Val Val Val  Glu Asp Leu Leu Pro  Asn His Ser 
    1565                 1570                 1575             


Tyr Val  Phe Arg Val Arg Ala  Gln Ser Gln Glu Gly  Trp Gly Arg 
    1580                 1585                 1590             


Glu Arg  Glu Gly Val Ile Thr  Ile Glu Ser Gln Val  His Pro Gln 
    1595                 1600                 1605             


Ser Pro  Leu Cys Pro Leu Pro  Gly Ser Ala Phe Thr  Leu Ser Thr 
    1610                 1615                 1620             


Pro Ser  Ala Pro Gly Pro Leu  Val Phe Thr Ala Leu  Ser Pro Asp 
    1625                 1630                 1635             


Ser Leu  Gln Leu Ser Trp Glu  Arg Pro Arg Arg Pro  Asn Gly Asp 
    1640                 1645                 1650             


Ile Val  Gly Tyr Leu Val Thr  Cys Glu Met Ala Gln  Gly Gly Gly 
    1655                 1660                 1665             


Pro Ala  Thr Ala Phe Arg Val  Asp Gly Asp Ser Pro  Glu Ser Arg 
    1670                 1675                 1680             


Leu Thr  Val Pro Gly Leu Ser  Glu Asn Val Pro Tyr  Lys Phe Lys 
    1685                 1690                 1695             


Val Gln  Ala Arg Thr Thr Glu  Gly Phe Gly Pro Glu  Arg Glu Gly 
    1700                 1705                 1710             


Ile Ile  Thr Ile Glu Ser Gln  Asp Gly Gly Pro Phe  Pro Gln Leu 
    1715                 1720                 1725             


Gly Ser  Arg Ala Gly Leu Phe  Gln His Pro Leu Gln  Ser Glu Tyr 
    1730                 1735                 1740             


Ser Ser  Ile Thr Thr Thr His  Thr Ser Ala Thr Glu  Pro Phe Leu 
    1745                 1750                 1755             


Val Asp  Gly Leu Thr Leu Gly  Ala Gln His Leu Glu  Ala Gly Gly 
    1760                 1765                 1770             


Ser Leu  Thr Arg His Val Thr  Gln Glu Phe Val Ser  Arg Thr Leu 
    1775                 1780                 1785             


Thr Thr  Ser Gly Thr Leu Ser  Thr His Met Asp Gln  Gln Phe Phe 
    1790                 1795                 1800             


Gln Thr  
    1805 


<210>  94
<211>  1752
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Gly Pro Arg Pro Ser Pro Trp Ala Arg Leu Leu Leu Ala Ala 
1               5                   10                  15      


Leu Ile Ser Val Ser Leu Ser Gly Thr Leu Ala Asn Arg Cys Lys Lys 
            20                  25                  30          


Ala Pro Val Lys Ser Cys Thr Glu Cys Val Arg Val Asp Lys Asp Cys 
        35                  40                  45              


Ala Tyr Cys Thr Asp Glu Met Phe Arg Asp Arg Arg Cys Asn Thr Gln 
    50                  55                  60                  


Ala Glu Leu Leu Ala Ala Gly Cys Gln Arg Glu Ser Ile Val Val Met 
65                  70                  75                  80  


Glu Ser Ser Phe Gln Ile Thr Glu Glu Thr Gln Ile Asp Thr Thr Leu 
                85                  90                  95      


Arg Arg Ser Gln Met Ser Pro Gln Gly Leu Arg Val Arg Leu Arg Pro 
            100                 105                 110         


Gly Glu Glu Arg His Phe Glu Leu Glu Val Phe Glu Pro Leu Glu Ser 
        115                 120                 125             


Pro Val Asp Leu Tyr Ile Leu Met Asp Phe Ser Asn Ser Met Ser Asp 
    130                 135                 140                 


Asp Leu Asp Asn Leu Lys Lys Met Gly Gln Asn Leu Ala Arg Val Leu 
145                 150                 155                 160 


Ser Gln Leu Thr Ser Asp Tyr Thr Ile Gly Phe Gly Lys Phe Val Asp 
                165                 170                 175     


Lys Val Ser Val Pro Gln Thr Asp Met Arg Pro Glu Lys Leu Lys Glu 
            180                 185                 190         


Pro Trp Pro Asn Ser Asp Pro Pro Phe Ser Phe Lys Asn Val Ile Ser 
        195                 200                 205             


Leu Thr Glu Asp Val Asp Glu Phe Arg Asn Lys Leu Gln Gly Glu Arg 
    210                 215                 220                 


Ile Ser Gly Asn Leu Asp Ala Pro Glu Gly Gly Phe Asp Ala Ile Leu 
225                 230                 235                 240 


Gln Thr Ala Val Cys Thr Arg Asp Ile Gly Trp Arg Pro Asp Ser Thr 
                245                 250                 255     


His Leu Leu Val Phe Ser Thr Glu Ser Ala Phe His Tyr Glu Ala Asp 
            260                 265                 270         


Gly Ala Asn Val Leu Ala Gly Ile Met Ser Arg Asn Asp Glu Arg Cys 
        275                 280                 285             


His Leu Asp Thr Thr Gly Thr Tyr Thr Gln Tyr Arg Thr Gln Asp Tyr 
    290                 295                 300                 


Pro Ser Val Pro Thr Leu Val Arg Leu Leu Ala Lys His Asn Ile Ile 
305                 310                 315                 320 


Pro Ile Phe Ala Val Thr Asn Tyr Ser Tyr Ser Tyr Tyr Glu Lys Leu 
                325                 330                 335     


His Thr Tyr Phe Pro Val Ser Ser Leu Gly Val Leu Gln Glu Asp Ser 
            340                 345                 350         


Ser Asn Ile Val Glu Leu Leu Glu Glu Ala Phe Asn Arg Ile Arg Ser 
        355                 360                 365             


Asn Leu Asp Ile Arg Ala Leu Asp Ser Pro Arg Gly Leu Arg Thr Glu 
    370                 375                 380                 


Val Thr Ser Lys Met Phe Gln Lys Thr Arg Thr Gly Ser Phe His Ile 
385                 390                 395                 400 


Arg Arg Gly Glu Val Gly Ile Tyr Gln Val Gln Leu Arg Ala Leu Glu 
                405                 410                 415     


His Val Asp Gly Thr His Val Cys Gln Leu Pro Glu Asp Gln Lys Gly 
            420                 425                 430         


Asn Ile His Leu Lys Pro Ser Phe Ser Asp Gly Leu Lys Met Asp Ala 
        435                 440                 445             


Gly Ile Ile Cys Asp Val Cys Thr Cys Glu Leu Gln Lys Glu Val Arg 
    450                 455                 460                 


Ser Ala Arg Cys Ser Phe Asn Gly Asp Phe Val Cys Gly Gln Cys Val 
465                 470                 475                 480 


Cys Ser Glu Gly Trp Ser Gly Gln Thr Cys Asn Cys Ser Thr Gly Ser 
                485                 490                 495     


Leu Ser Asp Ile Gln Pro Cys Leu Arg Glu Gly Glu Asp Lys Pro Cys 
            500                 505                 510         


Ser Gly Arg Gly Glu Cys Gln Cys Gly His Cys Val Cys Tyr Gly Glu 
        515                 520                 525             


Gly Arg Tyr Glu Gly Gln Phe Cys Glu Tyr Asp Asn Phe Gln Cys Pro 
    530                 535                 540                 


Arg Thr Ser Gly Phe Leu Cys Asn Asp Arg Gly Arg Cys Ser Met Gly 
545                 550                 555                 560 


Gln Cys Val Cys Glu Pro Gly Trp Thr Gly Pro Ser Cys Asp Cys Pro 
                565                 570                 575     


Leu Ser Asn Ala Thr Cys Ile Asp Ser Asn Gly Gly Ile Cys Asn Gly 
            580                 585                 590         


Arg Gly His Cys Glu Cys Gly Arg Cys His Cys His Gln Gln Ser Leu 
        595                 600                 605             


Tyr Thr Asp Thr Ile Cys Glu Ile Asn Tyr Ser Ala Ile His Pro Gly 
    610                 615                 620                 


Leu Cys Glu Asp Leu Arg Ser Cys Val Gln Cys Gln Ala Trp Gly Thr 
625                 630                 635                 640 


Gly Glu Lys Lys Gly Arg Thr Cys Glu Glu Cys Asn Phe Lys Val Lys 
                645                 650                 655     


Met Val Asp Glu Leu Lys Arg Ala Glu Glu Val Val Val Arg Cys Ser 
            660                 665                 670         


Phe Arg Asp Glu Asp Asp Asp Cys Thr Tyr Ser Tyr Thr Met Glu Gly 
        675                 680                 685             


Asp Gly Ala Pro Gly Pro Asn Ser Thr Val Leu Val His Lys Lys Lys 
    690                 695                 700                 


Asp Cys Pro Pro Gly Ser Phe Trp Trp Leu Ile Pro Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Ala Leu Leu Leu Leu Leu Cys Trp Lys Tyr Cys 
                725                 730                 735     


Ala Cys Cys Lys Ala Cys Leu Ala Leu Leu Pro Cys Cys Asn Arg Gly 
            740                 745                 750         


His Met Val Gly Phe Lys Glu Asp His Tyr Met Leu Arg Glu Asn Leu 
        755                 760                 765             


Met Ala Ser Asp His Leu Asp Thr Pro Met Leu Arg Ser Gly Asn Leu 
    770                 775                 780                 


Lys Gly Arg Asp Val Val Arg Trp Lys Val Thr Asn Asn Met Gln Arg 
785                 790                 795                 800 


Pro Gly Phe Ala Thr His Ala Ala Ser Ile Asn Pro Thr Glu Leu Val 
                805                 810                 815     


Pro Tyr Gly Leu Ser Leu Arg Leu Ala Arg Leu Cys Thr Glu Asn Leu 
            820                 825                 830         


Leu Lys Pro Asp Thr Arg Glu Cys Ala Gln Leu Arg Gln Glu Val Glu 
        835                 840                 845             


Glu Asn Leu Asn Glu Val Tyr Arg Gln Ile Ser Gly Val His Lys Leu 
    850                 855                 860                 


Gln Gln Thr Lys Phe Arg Gln Gln Pro Asn Ala Gly Lys Lys Gln Asp 
865                 870                 875                 880 


His Thr Ile Val Asp Thr Val Leu Met Ala Pro Arg Ser Ala Lys Pro 
                885                 890                 895     


Ala Leu Leu Lys Leu Thr Glu Lys Gln Val Glu Gln Arg Ala Phe His 
            900                 905                 910         


Asp Leu Lys Val Ala Pro Gly Tyr Tyr Thr Leu Thr Ala Asp Gln Asp 
        915                 920                 925             


Ala Arg Gly Met Val Glu Phe Gln Glu Gly Val Glu Leu Val Asp Val 
    930                 935                 940                 


Arg Val Pro Leu Phe Ile Arg Pro Glu Asp Asp Asp Glu Lys Gln Leu 
945                 950                 955                 960 


Leu Val Glu Ala Ile Asp Val Pro Ala Gly Thr Ala Thr Leu Gly Arg 
                965                 970                 975     


Arg Leu Val Asn Ile Thr Ile Ile Lys Glu Gln Ala Arg Asp Val Val 
            980                 985                 990         


Ser Phe Glu Gln Pro Glu Phe Ser  Val Ser Arg Gly Asp  Gln Val Ala 
        995                 1000                 1005             


Arg Ile  Pro Val Ile Arg Arg  Val Leu Asp Gly Gly  Lys Ser Gln 
    1010                 1015                 1020             


Val Ser  Tyr Arg Thr Gln Asp  Gly Thr Ala Gln Gly  Asn Arg Asp 
    1025                 1030                 1035             


Tyr Ile  Pro Val Glu Gly Glu  Leu Leu Phe Gln Pro  Gly Glu Ala 
    1040                 1045                 1050             


Trp Lys  Glu Leu Gln Val Lys  Leu Leu Glu Leu Gln  Glu Val Asp 
    1055                 1060                 1065             


Ser Leu  Leu Arg Gly Arg Gln  Val Arg Arg Phe His  Val Gln Leu 
    1070                 1075                 1080             


Ser Asn  Pro Lys Phe Gly Ala  His Leu Gly Gln Pro  His Ser Thr 
    1085                 1090                 1095             


Thr Ile  Ile Ile Arg Asp Pro  Asp Glu Leu Asp Arg  Ser Phe Thr 
    1100                 1105                 1110             


Ser Gln  Met Leu Ser Ser Gln  Pro Pro Pro His Gly  Asp Leu Gly 
    1115                 1120                 1125             


Ala Pro  Gln Asn Pro Asn Ala  Lys Ala Ala Gly Ser  Arg Lys Ile 
    1130                 1135                 1140             


His Phe  Asn Trp Leu Pro Pro  Ser Gly Lys Pro Met  Gly Tyr Arg 
    1145                 1150                 1155             


Val Lys  Tyr Trp Ile Gln Gly  Asp Ser Glu Ser Glu  Ala His Leu 
    1160                 1165                 1170             


Leu Asp  Ser Lys Val Pro Ser  Val Glu Leu Thr Asn  Leu Tyr Pro 
    1175                 1180                 1185             


Tyr Cys  Asp Tyr Glu Met Lys  Val Cys Ala Tyr Gly  Ala Gln Gly 
    1190                 1195                 1200             


Glu Gly  Pro Tyr Ser Ser Leu  Val Ser Cys Arg Thr  His Gln Glu 
    1205                 1210                 1215             


Val Pro  Ser Glu Pro Gly Arg  Leu Ala Phe Asn Val  Val Ser Ser 
    1220                 1225                 1230             


Thr Val  Thr Gln Leu Ser Trp  Ala Glu Pro Ala Glu  Thr Asn Gly 
    1235                 1240                 1245             


Glu Ile  Thr Ala Tyr Glu Val  Cys Tyr Gly Leu Val  Asn Asp Asp 
    1250                 1255                 1260             


Asn Arg  Pro Ile Gly Pro Met  Lys Lys Val Leu Val  Asp Asn Pro 
    1265                 1270                 1275             


Lys Asn  Arg Met Leu Leu Ile  Glu Asn Leu Arg Glu  Ser Gln Pro 
    1280                 1285                 1290             


Tyr Arg  Tyr Thr Val Lys Ala  Arg Asn Gly Ala Gly  Trp Gly Pro 
    1295                 1300                 1305             


Glu Arg  Glu Ala Ile Ile Asn  Leu Ala Thr Gln Pro  Lys Arg Pro 
    1310                 1315                 1320             


Met Ser  Ile Pro Ile Ile Pro  Asp Ile Pro Ile Val  Asp Ala Gln 
    1325                 1330                 1335             


Ser Gly  Glu Asp Tyr Asp Ser  Phe Leu Met Tyr Ser  Asp Asp Val 
    1340                 1345                 1350             


Leu Arg  Ser Pro Ser Gly Ser  Gln Arg Pro Ser Val  Ser Asp Asp 
    1355                 1360                 1365             


Thr Glu  His Leu Val Asn Gly  Arg Met Asp Phe Ala  Phe Pro Gly 
    1370                 1375                 1380             


Ser Thr  Asn Ser Leu His Arg  Met Thr Thr Thr Ser  Ala Ala Ala 
    1385                 1390                 1395             


Tyr Gly  Thr His Leu Ser Pro  His Val Pro His Arg  Val Leu Ser 
    1400                 1405                 1410             


Thr Ser  Ser Thr Leu Thr Arg  Asp Tyr Asn Ser Leu  Thr Arg Ser 
    1415                 1420                 1425             


Glu His  Ser His Ser Thr Thr  Leu Pro Arg Asp Tyr  Ser Thr Leu 
    1430                 1435                 1440             


Thr Ser  Val Ser Ser His Asp  Ser Arg Leu Thr Ala  Gly Val Pro 
    1445                 1450                 1455             


Asp Thr  Pro Thr Arg Leu Val  Phe Ser Ala Leu Gly  Pro Thr Ser 
    1460                 1465                 1470             


Leu Arg  Val Ser Trp Gln Glu  Pro Arg Cys Glu Arg  Pro Leu Gln 
    1475                 1480                 1485             


Gly Tyr  Ser Val Glu Tyr Gln  Leu Leu Asn Gly Gly  Glu Leu His 
    1490                 1495                 1500             


Arg Leu  Asn Ile Pro Asn Pro  Ala Gln Thr Ser Val  Val Val Glu 
    1505                 1510                 1515             


Asp Leu  Leu Pro Asn His Ser  Tyr Val Phe Arg Val  Arg Ala Gln 
    1520                 1525                 1530             


Ser Gln  Glu Gly Trp Gly Arg  Glu Arg Glu Gly Val  Ile Thr Ile 
    1535                 1540                 1545             


Glu Ser  Gln Val His Pro Gln  Ser Pro Leu Cys Pro  Leu Pro Gly 
    1550                 1555                 1560             


Ser Ala  Phe Thr Leu Ser Thr  Pro Ser Ala Pro Gly  Pro Leu Val 
    1565                 1570                 1575             


Phe Thr  Ala Leu Ser Pro Asp  Ser Leu Gln Leu Ser  Trp Glu Arg 
    1580                 1585                 1590             


Pro Arg  Arg Pro Asn Gly Asp  Ile Val Gly Tyr Leu  Val Thr Cys 
    1595                 1600                 1605             


Glu Met  Ala Gln Gly Gly Gly  Pro Ala Thr Ala Phe  Arg Val Asp 
    1610                 1615                 1620             


Gly Asp  Ser Pro Glu Ser Arg  Leu Thr Val Pro Gly  Leu Ser Glu 
    1625                 1630                 1635             


Asn Val  Pro Tyr Lys Phe Lys  Val Gln Ala Arg Thr  Thr Glu Gly 
    1640                 1645                 1650             


Phe Gly  Pro Glu Arg Glu Gly  Ile Ile Thr Ile Glu  Ser Gln Asp 
    1655                 1660                 1665             


Gly Gly  Pro Phe Pro Gln Leu  Gly Ser Arg Ala Gly  Leu Phe Gln 
    1670                 1675                 1680             


His Pro  Leu Gln Ser Glu Tyr  Ser Ser Ile Thr Thr  Thr His Thr 
    1685                 1690                 1695             


Ser Ala  Thr Glu Pro Phe Leu  Val Asp Gly Leu Thr  Leu Gly Ala 
    1700                 1705                 1710             


Gln His  Leu Glu Ala Gly Gly  Ser Leu Thr Arg His  Val Thr Gln 
    1715                 1720                 1725             


Glu Phe  Val Ser Arg Thr Leu  Thr Thr Ser Gly Thr  Leu Ser Thr 
    1730                 1735                 1740             


His Met  Asp Gln Gln Phe Phe  Gln Thr 
    1745                 1750         


<210>  95
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr Gly Arg Cys Pro Ala Gly 
            20                  25                  30          


Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala 
        35                  40                  45              


Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln 
    50                  55                  60                  


Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala 
65                  70                  75                  80  


Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly 
                85                  90                  95      


Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val 
            100                 105                 110         


Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg 
        115                 120                 125             


Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu Arg 
    130                 135                 140                 


Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu 
145                 150                 155                 160 


Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser 
                165                 170                 175     


Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser 
            180                 185                 190         


Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe 
        195                 200                 205             


His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val 
    210                 215                 220                 


Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu 
225                 230                 235                 240 


His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln 
                245                 250                 255     


Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser 
            260                 265                 270         


Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro 
        275                 280                 285             


Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro 
    290                 295                 300                 


Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu 
305                 310                 315                 320 


Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln 
                325                 330                 335     


Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val 
            340                 345                 350         


Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val 
        355                 360                 365             


Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln 
    370                 375                 380                 


Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val 
                405                 410                 415     


Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser 
            420                 425                 430         


Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu 
        435                 440                 445             


Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly 
    450                 455                 460                 


Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln 
465                 470                 475                 480 


Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro 
                485                 490                 495     


Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505                 510 


<210>  96
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Arg Arg Ala Ala Leu Trp Leu Trp Leu Cys Ala Leu Ala Leu Ser 
1               5                   10                  15      


Leu Gln Pro Ala Leu Pro Gln Ile Val Ala Thr Asn Leu Pro Pro Glu 
            20                  25                  30          


Asp Gln Asp Gly Ser Gly Asp Asp Ser Asp Asn Phe Ser Gly Ser Gly 
        35                  40                  45              


Ala Gly Ala Leu Gln Asp Ile Thr Leu Ser Gln Gln Thr Pro Ser Thr 
    50                  55                  60                  


Trp Lys Asp Thr Gln Leu Leu Thr Ala Ile Pro Thr Ser Pro Glu Pro 
65                  70                  75                  80  


Thr Gly Leu Glu Ala Thr Ala Ala Ser Thr Ser Thr Leu Pro Ala Gly 
                85                  90                  95      


Glu Gly Pro Lys Glu Gly Glu Ala Val Val Leu Pro Glu Val Glu Pro 
            100                 105                 110         


Gly Leu Thr Ala Arg Glu Gln Glu Ala Thr Pro Arg Pro Arg Glu Thr 
        115                 120                 125             


Thr Gln Leu Pro Thr Thr His Gln Ala Ser Thr Thr Thr Ala Thr Thr 
    130                 135                 140                 


Ala Gln Glu Pro Ala Thr Ser His Pro His Arg Asp Met Gln Pro Gly 
145                 150                 155                 160 


His His Glu Thr Ser Thr Pro Ala Gly Pro Ser Gln Ala Asp Leu His 
                165                 170                 175     


Thr Pro His Thr Glu Asp Gly Gly Pro Ser Ala Thr Glu Arg Ala Ala 
            180                 185                 190         


Glu Asp Gly Ala Ser Ser Gln Leu Pro Ala Ala Glu Gly Ser Gly Glu 
        195                 200                 205             


Gln Asp Phe Thr Phe Glu Thr Ser Gly Glu Asn Thr Ala Val Val Ala 
    210                 215                 220                 


Val Glu Pro Asp Arg Arg Asn Gln Ser Pro Val Asp Gln Gly Ala Thr 
225                 230                 235                 240 


Gly Ala Ser Gln Gly Leu Leu Asp Arg Lys Glu Val Leu Gly Gly Val 
                245                 250                 255     


Ile Ala Gly Gly Leu Val Gly Leu Ile Phe Ala Val Cys Leu Val Gly 
            260                 265                 270         


Phe Met Leu Tyr Arg Met Lys Lys Lys Asp Glu Gly Ser Tyr Ser Leu 
        275                 280                 285             


Glu Glu Pro Lys Gln Ala Asn Gly Gly Ala Tyr Gln Lys Pro Thr Lys 
    290                 295                 300                 


Gln Glu Glu Phe Tyr Ala 
305                 310 


<210>  97
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 
65                  70                  75                  80  


Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
        915                 920                 925 


<210>  98
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Glu Leu Glu Pro 
                325             


<210>  99
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Gly Glu Asp Pro Tyr Tyr Thr Glu Asn Gly Gly Gly 
                325                 330                 335     


Gln Gly Tyr Ser Ser Gly Pro Gly Thr Ser Pro Glu Ala Gln Gly Lys 
            340                 345                 350         


Ala Ser Val Asn Arg Gly Ala Gln Glu Asn Gly Thr Gly Gln Ala Thr 
        355                 360                 365             


Ser Arg Asn Gly His Ser Ala Arg Gln His Val Val Ala Asp Thr Glu 
    370                 375                 380                 


Leu 
385 


<210>  100
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Leu Arg Arg Pro Pro Arg Leu Arg Leu Cys Ala Arg Leu Pro 
1               5                   10                  15      


Asp Phe Phe Leu Leu Leu Leu Phe Arg Gly Cys Leu Ile Gly Ala Val 
            20                  25                  30          


Asn Leu Lys Ser Ser Asn Arg Thr Pro Val Val Gln Glu Phe Glu Ser 
        35                  40                  45              


Val Glu Leu Ser Cys Ile Ile Thr Asp Ser Gln Thr Ser Asp Pro Arg 
    50                  55                  60                  


Ile Glu Trp Lys Lys Ile Gln Asp Glu Gln Thr Thr Tyr Val Phe Phe 
65                  70                  75                  80  


Asp Asn Lys Ile Gln Gly Asp Leu Ala Gly Arg Ala Glu Ile Leu Gly 
                85                  90                  95      


Lys Thr Ser Leu Lys Ile Trp Asn Val Thr Arg Arg Asp Ser Ala Leu 
            100                 105                 110         


Tyr Arg Cys Glu Val Val Ala Arg Asn Asp Arg Lys Glu Ile Asp Glu 
        115                 120                 125             


Ile Val Ile Glu Leu Thr Val Gln Val Lys Pro Val Thr Pro Val Cys 
    130                 135                 140                 


Arg Val Pro Lys Ala Val Pro Val Gly Lys Met Ala Thr Leu His Cys 
145                 150                 155                 160 


Gln Glu Ser Glu Gly His Pro Arg Pro His Tyr Ser Trp Tyr Arg Asn 
                165                 170                 175     


Asp Val Pro Leu Pro Thr Asp Ser Arg Ala Asn Pro Arg Phe Arg Asn 
            180                 185                 190         


Ser Ser Phe His Leu Asn Ser Glu Thr Gly Thr Leu Val Phe Thr Ala 
        195                 200                 205             


Val His Lys Asp Asp Ser Gly Gln Tyr Tyr Cys Ile Ala Ser Asn Asp 
    210                 215                 220                 


Ala Gly Ser Ala Arg Cys Glu Glu Gln Glu Met Glu Val Tyr Asp Leu 
225                 230                 235                 240 


Asn Ile Gly Gly Ile Ile Gly Gly Val Leu Val Val Leu Ala Val Leu 
                245                 250                 255     


Ala Leu Ile Thr Leu Gly Ile Cys Cys Ala Tyr Arg Arg Gly Tyr Phe 
            260                 265                 270         


Ile Asn Asn Lys Gln Asp Gly Glu Ser Tyr Lys Asn Pro Gly Lys Pro 
        275                 280                 285             


Asp Gly Val Asn Tyr Ile Arg Thr Asp Glu Glu Gly Asp Phe Arg His 
    290                 295                 300                 


Lys Ser Ser Phe Val Ile 
305                 310 


<210>  101
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ala Leu Arg Arg Pro Pro Arg Leu Arg Leu Cys Ala Arg Leu Pro 
1               5                   10                  15      


Asp Phe Phe Leu Leu Leu Leu Phe Arg Gly Cys Leu Ile Gly Ala Val 
            20                  25                  30          


Asn Leu Lys Ser Ser Asn Arg Thr Pro Val Val Gln Glu Phe Glu Ser 
        35                  40                  45              


Val Glu Leu Ser Cys Ile Ile Thr Asp Ser Gln Thr Ser Asp Pro Arg 
    50                  55                  60                  


Ile Glu Trp Lys Lys Ile Gln Asp Glu Gln Thr Thr Tyr Val Phe Phe 
65                  70                  75                  80  


Asp Asn Lys Ile Gln Val Lys Pro Val Thr Pro Val Cys Arg Val Pro 
                85                  90                  95      


Lys Ala Val Pro Val Gly Lys Met Ala Thr Leu His Cys Gln Glu Ser 
            100                 105                 110         


Glu Gly His Pro Arg Pro His Tyr Ser Trp Tyr Arg Asn Asp Val Pro 
        115                 120                 125             


Leu Pro Thr Asp Ser Arg Ala Asn Pro Arg Phe Arg Asn Ser Ser Phe 
    130                 135                 140                 


His Leu Asn Ser Glu Thr Gly Thr Leu Val Phe Thr Ala Val His Lys 
145                 150                 155                 160 


Asp Asp Ser Gly Gln Tyr Tyr Cys Ile Ala Ser Asn Asp Ala Gly Ser 
                165                 170                 175     


Ala Arg Cys Glu Glu Gln Glu Met Glu Val Tyr Asp Leu Asn Ile Gly 
            180                 185                 190         


Gly Ile Ile Gly Gly Val Leu Val Val Leu Ala Val Leu Ala Leu Ile 
        195                 200                 205             


Thr Leu Gly Ile Cys Cys Ala Tyr Arg Arg Gly Tyr Phe Ile Asn Asn 
    210                 215                 220                 


Lys Gln Asp Gly Glu Ser Tyr Lys Asn Pro Gly Lys Pro Asp Gly Val 
225                 230                 235                 240 


Asn Tyr Ile Arg Thr Asp Glu Glu Gly Asp Phe Arg His Lys Ser Ser 
                245                 250                 255     


Phe Val Ile 
            


<210>  102
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210>  103
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ser Gly Val Val Pro Thr Ala Pro Glu Gln Pro Ala Gly Glu Met 
1               5                   10                  15      


Glu Asn Gln Thr Lys Pro Pro Asp Pro Arg Pro Asp Ala Pro Pro Glu 
            20                  25                  30          


Tyr Asn Ser His Phe Leu Pro Gly Pro Pro Gly Thr Ala Val Pro Pro 
        35                  40                  45              


Pro Thr Gly Tyr Pro Gly Gly Leu Pro Met Gly Tyr Tyr Ser Pro Gln 
    50                  55                  60                  


Gln Pro Ser Thr Phe Pro Leu Tyr Gln Pro Val Gly Gly Ile His Pro 
65                  70                  75                  80  


Val Arg Tyr Gln Pro Gly Lys Tyr Pro Met Pro Asn Gln Ser Val Pro 
                85                  90                  95      


Ile Thr Trp Met Pro Gly Pro Thr Pro Met Ala Asn Cys Pro Pro Gly 
            100                 105                 110         


Leu Glu Tyr Leu Val Gln Leu Asp Asn Ile His Val Leu Gln His Phe 
        115                 120                 125             


Glu Pro Leu Glu Met Met Thr Cys Phe Glu Thr Asn Asn Arg Tyr Asp 
    130                 135                 140                 


Ile Lys Asn Asn Ser Asp Gln Met Val Tyr Ile Val Thr Glu Asp Thr 
145                 150                 155                 160 


Asp Asp Phe Thr Arg Asn Ala Tyr Arg Thr Leu Arg Pro Phe Val Leu 
                165                 170                 175     


Arg Val Thr Asp Cys Met Gly Arg Glu Ile Met Thr Met Gln Arg Pro 
            180                 185                 190         


Phe Arg Cys Thr Cys Cys Cys Phe Cys Cys Pro Ser Ala Arg Gln Glu 
        195                 200                 205             


Leu Glu Val Gln Cys Pro Pro Gly Val Thr Ile Gly Phe Val Ala Glu 
    210                 215                 220                 


His Trp Asn Leu Cys Arg Ala Val Tyr Ser Ile Gln Asn Glu Lys Lys 
225                 230                 235                 240 


Glu Asn Val Met Arg Val Arg Gly Pro Cys Ser Thr Tyr Gly Cys Gly 
                245                 250                 255     


Ser Asp Ser Val Phe Glu Val Lys Ser Leu Asp Gly Ile Ser Asn Ile 
            260                 265                 270         


Gly Ser Ile Ile Arg Lys Trp Asn Gly Leu Leu Ser Ala Met Ala Asp 
        275                 280                 285             


Ala Asp His Phe Asp Ile His Phe Pro Leu Asp Leu Asp Val Lys Met 
    290                 295                 300                 


Lys Ala Met Ile Phe Gly Ala Cys Phe Leu Ile Asp Phe Met Tyr Phe 
305                 310                 315                 320 


Glu Arg Ser Pro Pro Gln Arg Ser Arg 
                325                 


<210>  104
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ser Gly Val Val Pro Thr Ala Pro Glu Gln Pro Ala Gly Glu Met 
1               5                   10                  15      


Glu Asn Gln Thr Lys Pro Pro Asp Pro Arg Pro Asp Ala Pro Pro Glu 
            20                  25                  30          


Tyr Asn Ser His Phe Leu Pro Gly Pro Pro Gly Thr Ala Val Pro Pro 
        35                  40                  45              


Pro Thr Gly Tyr Pro Gly Gly Leu Pro Met Gly Tyr Tyr Ser Pro Gln 
    50                  55                  60                  


Gln Pro Ser Thr Phe Pro Leu Tyr Gln Pro Val Gly Gly Ile His Pro 
65                  70                  75                  80  


Val Arg Tyr Gln Pro Gly Lys Tyr Pro Met Pro Asn Gln Ser Val Pro 
                85                  90                  95      


Ile Thr Trp Met Pro Gly Pro Thr Pro Met Ala Asn Cys Pro Pro Gly 
            100                 105                 110         


Leu Glu Tyr Leu Val Gln Leu Glu Val Gln Cys Pro Pro Gly Val Thr 
        115                 120                 125             


Ile Gly Phe Val Ala Glu His Trp Asn Leu Cys Arg Ala Val Tyr Ser 
    130                 135                 140                 


Ile Gln Asn Glu Lys Lys Glu Asn Val Met Arg Val Arg Gly Pro Cys 
145                 150                 155                 160 


Ser Thr Tyr Gly Cys Gly Ser Asp Ser Val Phe Glu Val Lys Ser Leu 
                165                 170                 175     


Asp Gly Ile Ser Asn Ile Gly Ser Ile Ile Arg Lys Trp Asn Gly Leu 
            180                 185                 190         


Leu Ser Ala Met Ala Asp Ala Asp His Phe Asp Ile His Phe Pro Leu 
        195                 200                 205             


Asp Leu Asp Val Lys Met Lys Ala Met Ile Phe Gly Ala Cys Phe Leu 
    210                 215                 220                 


Ile Asp Phe Met Tyr Phe Glu Arg Ser Pro Pro Gln Arg Ser Arg 
225                 230                 235                 


<210>  105
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Glu Asn Gln Thr Lys Pro Pro Asp Pro Arg Pro Asp Ala Pro Pro 
1               5                   10                  15      


Glu Tyr Asn Ser His Phe Leu Pro Gly Pro Pro Gly Thr Ala Val Pro 
            20                  25                  30          


Pro Pro Thr Gly Tyr Pro Gly Gly Leu Pro Met Gly Tyr Tyr Ser Pro 
        35                  40                  45              


Gln Gln Pro Ser Thr Phe Pro Leu Tyr Gln Pro Val Gly Gly Ile His 
    50                  55                  60                  


Pro Val Arg Tyr Gln Pro Gly Lys Tyr Pro Met Pro Asn Gln Ser Val 
65                  70                  75                  80  


Pro Ile Thr Trp Met Pro Gly Pro Thr Pro Met Ala Asn Cys Pro Pro 
                85                  90                  95      


Gly Leu Glu Tyr Leu Val Gln Leu Glu Val Gln Cys Pro Pro Gly Val 
            100                 105                 110         


Thr Ile Gly Phe Val Ala Glu His Trp Asn Leu Cys Arg Ala Val Tyr 
        115                 120                 125             


Ser Ile Gln Asn Glu Lys Lys Glu Asn Val Met Arg Val Arg Gly Pro 
    130                 135                 140                 


Cys Ser Thr Tyr Gly Cys Gly Ser Asp Ser Val Phe Glu Val Lys Ser 
145                 150                 155                 160 


Leu Asp Gly Ile Ser Asn Ile Gly Ser Ile Ile Arg Lys Trp Asn Gly 
                165                 170                 175     


Leu Leu Ser Ala Met Ala Asp Ala Asp His Phe Asp Ile His Phe Pro 
            180                 185                 190         


Leu Asp Leu Asp Val Lys Met Lys Ala Met Ile Phe Gly Ala Cys Phe 
        195                 200                 205             


Leu Ile Asp Phe Met Tyr Phe Glu Arg Ser Pro Pro Gln Arg Ser Arg 
    210                 215                 220                 


<210>  106
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Pro Arg Ala Gln Pro Ser Ser Ala Ser Tyr Gln Pro Val Pro Ala 
1               5                   10                  15      


Asp Pro Phe Ala Ile Val Ser Arg Ala Gln Gln Met Val Glu Ile Leu 
            20                  25                  30          


Ser Asp Glu Asn Arg Asn Leu Arg Gln Glu Leu Glu Gly Cys Tyr Glu 
        35                  40                  45              


Lys Val Ala Arg Leu Gln Lys Val Glu Thr Glu Ile Gln Arg Val Ser 
    50                  55                  60                  


Glu Ala Tyr Glu Asn Leu Val Lys Ser Ser Ser Lys Arg Glu Ala Leu 
65                  70                  75                  80  


Glu Lys Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Met His 
                85                  90                  95      


Asp Phe Asn Arg Asp Leu Arg Glu Arg Leu Glu Thr Ala Asn Lys Gln 
            100                 105                 110         


Leu Ala Glu Lys Glu Tyr Glu Gly Ser Glu Asp Thr Arg Lys Thr Ile 
        115                 120                 125             


Ser Gln Leu Phe Ala Lys Asn Lys Glu Ser Gln Arg Glu Lys Glu Lys 
    130                 135                 140                 


Leu Glu Ala Glu Leu Ala Thr Ala Arg Ser Thr Asn Glu Asp Gln Arg 
145                 150                 155                 160 


Arg His Ile Glu Ile Arg Asp Gln Ala Leu Ser Asn Ala Gln Ala Lys 
                165                 170                 175     


Val Val Lys Leu Glu Glu Glu Leu Lys Lys Lys Gln Val Tyr Val Asp 
            180                 185                 190         


Lys Val Glu Lys Met Gln Gln Ala Leu Val Gln Leu Gln Ala Ala Cys 
        195                 200                 205             


Glu Lys Arg Glu Gln Leu Glu His Arg Leu Arg Thr Arg Leu Glu Arg 
    210                 215                 220                 


Glu Leu Glu Ser Leu Arg Ile Gln Gln Arg Gln Gly Asn Cys Gln Pro 
225                 230                 235                 240 


Thr Asn Val Ser Glu Tyr Asn Ala Ala Ala Leu Met Glu Leu Leu Arg 
                245                 250                 255     


Glu Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Thr Lys Trp 
            260                 265                 270         


Glu Gln Lys Tyr Leu Glu Glu Asn Val Met Arg His Phe Ala Leu Asp 
        275                 280                 285             


Ala Ala Ala Thr Val Ala Ala Gln Arg Asp Thr Thr Val Ile Ser His 
    290                 295                 300                 


Ser Pro Asn Thr Ser Tyr Asp Thr Ala Leu Glu Ala Arg Ile Gln Lys 
305                 310                 315                 320 


Glu Glu Glu Glu Ile Leu Met Ala Asn Lys Arg Cys Leu Asp Met Glu 
                325                 330                 335     


Gly Arg Ile Lys Thr Leu His Ala Gln Ile Ile Glu Lys Asp Ala Met 
            340                 345                 350         


Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Glu Pro Ser Lys Thr Glu 
        355                 360                 365             


Gln Leu Ser Cys Met Arg Pro Ala Lys Ser Leu Met Ser Ile Ser Asn 
    370                 375                 380                 


Ala Gly Ser Gly Leu Leu Ser His Ser Ser Thr Leu Thr Gly Ser Pro 
385                 390                 395                 400 


Ile Met Glu Glu Lys Arg Asp Asp Lys Ser Trp Lys Gly Ser Leu Gly 
                405                 410                 415     


Ile Leu Leu Gly Gly Asp Tyr Arg Ala Glu Tyr Val Pro Ser Thr Pro 
            420                 425                 430         


Ser Pro Val Pro Pro Ser Thr Pro Leu Leu Ser Ala His Ser Lys Thr 
        435                 440                 445             


Gly Ser Arg Asp Cys Ser Thr Gln Thr Glu Arg Gly Thr Glu Ser Asn 
    450                 455                 460                 


Lys Thr Ala Ala Val Ala Pro Ile Ser Val Pro Ala Pro Val Ala Ala 
465                 470                 475                 480 


Ala Ala Thr Ala Ala Ala Ile Thr Ala Thr Ala Ala Thr Ile Thr Thr 
                485                 490                 495     


Thr Met Val Ala Ala Ala Pro Val Ala Val Ala Ala Ala Ala Ala Pro 
            500                 505                 510         


Ala Ala Ala Ala Ala Pro Ser Pro Ala Thr Ala Ala Ala Thr Ala Ala 
        515                 520                 525             


Ala Val Ser Pro Ala Ala Ala Gly Gln Ile Pro Ala Ala Ala Ser Val 
    530                 535                 540                 


Ala Ser Ala Ala Ala Val Ala Pro Ser Ala Ala Ala Ala Ala Ala Val 
545                 550                 555                 560 


Gln Val Ala Pro Ala Ala Pro Ala Pro Val Pro Ala Pro Ala Leu Val 
                565                 570                 575     


Pro Val Pro Ala Pro Ala Ala Ala Gln Ala Ser Ala Pro Ala Gln Thr 
            580                 585                 590         


Gln Ala Pro Thr Ser Ala Pro Ala Val Ala Pro Thr Pro Ala Pro Thr 
        595                 600                 605             


Pro Thr Pro Ala Val Ala Gln Ala Glu Val Pro Ala Ser Pro Ala Thr 
    610                 615                 620                 


Gly Pro Gly Pro His Arg Leu Ser Ile Pro Ser Leu Thr Cys Asn Pro 
625                 630                 635                 640 


Asp Lys Thr Asp Gly Pro Val Phe His Ser Asn Thr Leu Glu Arg Lys 
                645                 650                 655     


Thr Pro Ile Gln Ile Leu Gly Gln Glu Pro Asp Ala Glu Met Val Glu 
            660                 665                 670         


Tyr Leu Ile 
        675 


<210>  107
<211>  1084
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Arg Asn Ser Glu Glu Gln Pro Ser Gly Gly Thr Thr Val Leu Gln 
1               5                   10                  15      


Arg Leu Leu Gln Glu Gln Leu Arg Tyr Gly Asn Pro Ser Glu Asn Arg 
            20                  25                  30          


Ser Leu Leu Ala Ile His Gln Gln Ala Thr Gly Asn Gly Pro Pro Phe 
        35                  40                  45              


Pro Ser Gly Ser Gly Asn Pro Gly Pro Gln Ser Asp Val Leu Ser Pro 
    50                  55                  60                  


Gln Asp His His Gln Gln Leu Val Ala His Ala Ala Arg Gln Glu Pro 
65                  70                  75                  80  


Gln Gly Gln Glu Ile Gln Ser Glu Asn Leu Ile Met Glu Lys Gln Leu 
                85                  90                  95      


Ser Pro Arg Met Gln Asn Asn Glu Glu Leu Pro Thr Tyr Glu Glu Ala 
            100                 105                 110         


Lys Val Gln Ser Gln Tyr Phe Arg Gly Gln Gln His Ala Ser Val Gly 
        115                 120                 125             


Ala Ala Phe Tyr Val Thr Gly Val Thr Asn Gln Lys Met Arg Thr Glu 
    130                 135                 140                 


Gly Arg Pro Ser Val Gln Arg Leu Asn Pro Gly Lys Met His Gln Asp 
145                 150                 155                 160 


Glu Gly Leu Arg Asp Leu Lys Gln Gly His Val Arg Ser Leu Ser Glu 
                165                 170                 175     


Arg Leu Met Gln Met Ser Leu Ala Thr Ser Gly Val Lys Ala His Pro 
            180                 185                 190         


Pro Val Thr Ser Ala Pro Leu Ser Pro Pro Gln Pro Asn Asp Leu Tyr 
        195                 200                 205             


Lys Asn Pro Thr Ser Ser Ser Glu Phe Tyr Lys Ala Gln Gly Pro Leu 
    210                 215                 220                 


Pro Asn Gln His Ser Leu Lys Gly Met Glu His Arg Gly Pro Pro Pro 
225                 230                 235                 240 


Glu Tyr Pro Phe Lys Gly Met Pro Pro Gln Ser Val Val Cys Lys Pro 
                245                 250                 255     


Gln Glu Pro Gly His Phe Tyr Ser Glu His Arg Leu Asn Gln Pro Gly 
            260                 265                 270         


Arg Thr Glu Gly Gln Leu Met Arg Tyr Gln His Pro Pro Glu Tyr Gly 
        275                 280                 285             


Ala Ala Arg Pro Ala Gln Asp Ile Ser Leu Pro Leu Ser Ala Arg Asn 
    290                 295                 300                 


Ser Gln Pro His Ser Pro Thr Ser Ser Leu Thr Ser Gly Gly Ser Leu 
305                 310                 315                 320 


Pro Leu Leu Gln Ser Pro Pro Ser Thr Arg Leu Ser Pro Ala Arg His 
                325                 330                 335     


Pro Leu Val Pro Asn Gln Gly Asp His Ser Ala His Leu Pro Arg Pro 
            340                 345                 350         


Gln Gln His Phe Leu Pro Asn Gln Ala His Gln Gly Asp His Tyr Arg 
        355                 360                 365             


Leu Ser Gln Pro Gly Leu Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    370                 375                 380                 


His His His His His His His Gln Gln Gln Gln Gln Gln Gln Pro Gln 
385                 390                 395                 400 


Gln Gln Pro Gly Glu Ala Tyr Ser Ala Met Pro Arg Ala Gln Pro Ser 
                405                 410                 415     


Ser Ala Ser Tyr Gln Pro Val Pro Ala Asp Pro Phe Ala Ile Val Ser 
            420                 425                 430         


Arg Ala Gln Gln Met Val Glu Ile Leu Ser Asp Glu Asn Arg Asn Leu 
        435                 440                 445             


Arg Gln Glu Leu Glu Gly Cys Tyr Glu Lys Val Ala Arg Leu Gln Lys 
    450                 455                 460                 


Val Glu Thr Glu Ile Gln Arg Val Ser Glu Ala Tyr Glu Asn Leu Val 
465                 470                 475                 480 


Lys Ser Ser Ser Lys Arg Glu Ala Leu Glu Lys Ala Met Arg Asn Lys 
                485                 490                 495     


Leu Glu Gly Glu Ile Arg Arg Met His Asp Phe Asn Arg Asp Leu Arg 
            500                 505                 510         


Glu Arg Leu Glu Thr Ala Asn Lys Gln Leu Ala Glu Lys Glu Tyr Glu 
        515                 520                 525             


Gly Ser Glu Asp Thr Arg Lys Thr Ile Ser Gln Leu Phe Ala Lys Asn 
    530                 535                 540                 


Lys Glu Ser Gln Arg Glu Lys Glu Lys Leu Glu Ala Glu Leu Ala Thr 
545                 550                 555                 560 


Ala Arg Ser Thr Asn Glu Asp Gln Arg Arg His Ile Glu Ile Arg Asp 
                565                 570                 575     


Gln Ala Leu Ser Asn Ala Gln Ala Lys Val Val Lys Leu Glu Glu Glu 
            580                 585                 590         


Leu Lys Lys Lys Gln Val Tyr Val Asp Lys Val Glu Lys Met Gln Gln 
        595                 600                 605             


Ala Leu Val Gln Leu Gln Ala Ala Cys Glu Lys Arg Glu Gln Leu Glu 
    610                 615                 620                 


His Arg Leu Arg Thr Arg Leu Glu Arg Glu Leu Glu Ser Leu Arg Ile 
625                 630                 635                 640 


Gln Gln Arg Gln Gly Asn Cys Gln Pro Thr Asn Val Ser Glu Tyr Asn 
                645                 650                 655     


Ala Ala Ala Leu Met Glu Leu Leu Arg Glu Lys Glu Glu Arg Ile Leu 
            660                 665                 670         


Ala Leu Glu Ala Asp Met Thr Lys Trp Glu Gln Lys Tyr Leu Glu Glu 
        675                 680                 685             


Asn Val Met Arg His Phe Ala Leu Asp Ala Ala Ala Thr Val Ala Ala 
    690                 695                 700                 


Gln Arg Asp Thr Thr Val Ile Ser His Ser Pro Asn Thr Ser Tyr Asp 
705                 710                 715                 720 


Thr Ala Leu Glu Ala Arg Ile Gln Lys Glu Glu Glu Glu Ile Leu Met 
                725                 730                 735     


Ala Asn Lys Arg Cys Leu Asp Met Glu Gly Arg Ile Lys Thr Leu His 
            740                 745                 750         


Ala Gln Ile Ile Glu Lys Asp Ala Met Ile Lys Val Leu Gln Gln Arg 
        755                 760                 765             


Ser Arg Lys Glu Pro Ser Lys Thr Glu Gln Leu Ser Cys Met Arg Pro 
    770                 775                 780                 


Ala Lys Ser Leu Met Ser Ile Ser Asn Ala Gly Ser Gly Leu Leu Ser 
785                 790                 795                 800 


His Ser Ser Thr Leu Thr Gly Ser Pro Ile Met Glu Glu Lys Arg Asp 
                805                 810                 815     


Asp Lys Ser Trp Lys Gly Ser Leu Gly Ile Leu Leu Gly Gly Asp Tyr 
            820                 825                 830         


Arg Ala Glu Tyr Val Pro Ser Thr Pro Ser Pro Val Pro Pro Ser Thr 
        835                 840                 845             


Pro Leu Leu Ser Ala His Ser Lys Thr Gly Ser Arg Asp Cys Ser Thr 
    850                 855                 860                 


Gln Thr Glu Arg Gly Thr Glu Ser Asn Lys Thr Ala Ala Val Ala Pro 
865                 870                 875                 880 


Ile Ser Val Pro Ala Pro Val Ala Ala Ala Ala Thr Ala Ala Ala Ile 
                885                 890                 895     


Thr Ala Thr Ala Ala Thr Ile Thr Thr Thr Met Val Ala Ala Ala Pro 
            900                 905                 910         


Val Ala Val Ala Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Pro Ser 
        915                 920                 925             


Pro Ala Thr Ala Ala Ala Thr Ala Ala Ala Val Ser Pro Ala Ala Ala 
    930                 935                 940                 


Gly Gln Ile Pro Ala Ala Ala Ser Val Ala Ser Ala Ala Ala Val Ala 
945                 950                 955                 960 


Pro Ser Ala Ala Ala Ala Ala Ala Val Gln Val Ala Pro Ala Ala Pro 
                965                 970                 975     


Ala Pro Val Pro Ala Pro Ala Leu Val Pro Val Pro Ala Pro Ala Ala 
            980                 985                 990         


Ala Gln Ala Ser Ala Pro Ala Gln  Thr Gln Ala Pro Thr  Ser Ala Pro 
        995                 1000                 1005             


Ala Val  Ala Pro Thr Pro Ala  Pro Thr Pro Thr Pro  Ala Val Ala 
    1010                 1015                 1020             


Gln Ala  Glu Val Pro Ala Ser  Pro Ala Thr Gly Pro  Gly Pro His 
    1025                 1030                 1035             


Arg Leu  Ser Ile Pro Ser Leu  Thr Cys Asn Pro Asp  Lys Thr Asp 
    1040                 1045                 1050             


Gly Pro  Val Phe His Ser Asn  Thr Leu Glu Arg Lys  Thr Pro Ile 
    1055                 1060                 1065             


Gln Ile  Leu Gly Gln Glu Pro  Asp Ala Glu Met Val  Glu Tyr Leu 
    1070                 1075                 1080             


Ile 
    


<210>  108
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Asn Phe Ala Glu Arg Glu Gly Ser Lys Arg Tyr Cys Ile Gln Thr 
1               5                   10                  15      


Lys His Val Ala Ile Leu Cys Ala Val Val Val Gly Val Gly Leu Ile 
            20                  25                  30          


Val Gly Leu Ala Val Gly Leu Thr Arg Ser Cys Asp Ser Ser Gly Asp 
        35                  40                  45              


Gly Gly Pro Gly Thr Ala Pro Ala Pro Ser His Leu Pro Ser Ser Thr 
    50                  55                  60                  


Ala Ser Pro Ser Gly Pro Pro Ala Gln Asp Gln Asp Ile Cys Pro Ala 
65                  70                  75                  80  


Ser Glu Asp Glu Ser Gly Gln Trp Lys Asn Phe Arg Leu Pro Asp Phe 
                85                  90                  95      


Val Asn Pro Val His Tyr Asp Leu His Val Lys Pro Leu Leu Glu Glu 
            100                 105                 110         


Asp Thr Tyr Thr Gly Thr Val Ser Ile Ser Ile Asn Leu Ser Ala Pro 
        115                 120                 125             


Thr Arg Tyr Leu Trp Leu His Leu Arg Glu Thr Arg Ile Thr Arg Leu 
    130                 135                 140                 


Pro Glu Leu Lys Arg Pro Ser Gly Asp Gln Val Gln Val Arg Arg Cys 
145                 150                 155                 160 


Phe Glu Tyr Lys Lys Gln Glu Tyr Val Val Val Glu Ala Glu Glu Glu 
                165                 170                 175     


Leu Thr Pro Ser Ser Gly Asp Gly Leu Tyr Leu Leu Thr Met Glu Phe 
            180                 185                 190         


Ala Gly Trp Leu Asn Gly Ser Leu Val Gly Phe Tyr Arg Thr Thr Tyr 
        195                 200                 205             


Thr Glu Asn Gly Gln Val Lys Ser Ile Val Ala Thr Asp His Glu Pro 
    210                 215                 220                 


Thr Asp Ala Arg Lys Ser Phe Pro Cys Phe Asp Glu Pro Asn Lys Lys 
225                 230                 235                 240 


Ala Thr Tyr Thr Ile Ser Ile Thr His Pro Lys Glu Tyr Gly Ala Leu 
                245                 250                 255     


Ser Asn Met Pro Val Ala Lys Glu Glu Ser Val Asp Asp Lys Trp Thr 
            260                 265                 270         


Arg Thr Thr Phe Glu Lys Ser Val Pro Met Ser Thr Tyr Leu Val Cys 
        275                 280                 285             


Phe Ala Val His Gln Phe Asp Ser Val Lys Arg Ile Ser Asn Ser Gly 
    290                 295                 300                 


Lys Pro Leu Thr Ile Tyr Val Gln Pro Glu Gln Lys His Thr Ala Glu 
305                 310                 315                 320 


Tyr Ala Ala Asn Ile Thr Lys Ser Val Phe Asp Tyr Phe Glu Glu Tyr 
                325                 330                 335     


Phe Ala Met Asn Tyr Ser Leu Pro Lys Leu Asp Lys Ile Ala Ile Pro 
            340                 345                 350         


Asp Phe Gly Thr Gly Ala Met Glu Asn Trp Gly Leu Ile Thr Tyr Arg 
        355                 360                 365             


Glu Thr Asn Leu Leu Tyr Asp Pro Lys Glu Ser Ala Ser Ser Asn Gln 
    370                 375                 380                 


Gln Arg Val Ala Thr Val Val Ala His Glu Leu Val His Gln Trp Phe 
385                 390                 395                 400 


Gly Asn Ile Val Thr Met Asp Trp Trp Glu Asp Leu Trp Leu Asn Glu 
                405                 410                 415     


Gly Phe Ala Ser Phe Phe Glu Phe Leu Gly Val Asn His Ala Glu Thr 
            420                 425                 430         


Asp Trp Gln Met Arg Asp Gln Met Leu Leu Glu Asp Val Leu Pro Val 
        435                 440                 445             


Gln Glu Asp Asp Ser Leu Met Ser Ser His Pro Ile Ile Val Thr Val 
    450                 455                 460                 


Thr Thr Pro Asp Glu Ile Thr Ser Val Phe Asp Gly Ile Ser Tyr Ser 
465                 470                 475                 480 


Lys Gly Ser Ser Ile Leu Arg Met Leu Glu Asp Trp Ile Lys Pro Glu 
                485                 490                 495     


Asn Phe Gln Lys Gly Cys Gln Met Tyr Leu Glu Lys Tyr Gln Phe Lys 
            500                 505                 510         


Asn Ala Lys Thr Ser Asp Phe Trp Ala Ala Leu Glu Glu Ala Ser Arg 
        515                 520                 525             


Leu Pro Val Lys Glu Val Met Asp Thr Trp Thr Arg Gln Met Gly Tyr 
    530                 535                 540                 


Pro Val Leu Asn Val Asn Gly Val Lys Asn Ile Thr Gln Lys Arg Phe 
545                 550                 555                 560 


Leu Leu Asp Pro Arg Ala Asn Pro Ser Gln Pro Pro Ser Asp Leu Gly 
                565                 570                 575     


Tyr Thr Trp Asn Ile Pro Val Lys Trp Thr Glu Asp Asn Ile Thr Ser 
            580                 585                 590         


Ser Val Leu Phe Asn Arg Ser Glu Lys Glu Gly Ile Thr Leu Asn Ser 
        595                 600                 605             


Ser Asn Pro Ser Gly Asn Ala Phe Leu Lys Ile Asn Pro Asp His Ile 
    610                 615                 620                 


Gly Phe Tyr Arg Val Asn Tyr Glu Val Ala Thr Trp Asp Ser Ile Ala 
625                 630                 635                 640 


Thr Ala Leu Ser Leu Asn His Lys Thr Phe Ser Ser Ala Asp Arg Ala 
                645                 650                 655     


Ser Leu Ile Asp Asp Ala Phe Ala Leu Ala Arg Ala Gln Leu Leu Asp 
            660                 665                 670         


Tyr Lys Val Ala Leu Asn Leu Thr Lys Tyr Leu Lys Arg Glu Glu Asn 
        675                 680                 685             


Phe Leu Pro Trp Gln Arg Val Ile Ser Ala Val Thr Tyr Ile Ile Ser 
    690                 695                 700                 


Met Phe Glu Asp Asp Lys Glu Leu Tyr Pro Met Ile Glu Glu Tyr Phe 
705                 710                 715                 720 


Gln Gly Gln Val Lys Pro Ile Ala Asp Ser Leu Gly Trp Asn Asp Ala 
                725                 730                 735     


Gly Asp His Val Thr Lys Leu Leu Arg Ser Ser Val Leu Gly Phe Ala 
            740                 745                 750         


Cys Lys Met Gly Asp Arg Glu Ala Leu Asn Asn Ala Ser Ser Leu Phe 
        755                 760                 765             


Glu Gln Trp Leu Asn Gly Thr Val Ser Leu Pro Val Asn Leu Arg Leu 
    770                 775                 780                 


Leu Val Tyr Arg Tyr Gly Met Gln Asn Ser Gly Asn Glu Ile Ser Trp 
785                 790                 795                 800 


Asn Tyr Thr Leu Glu Gln Tyr Gln Lys Thr Ser Leu Ala Gln Glu Lys 
                805                 810                 815     


Glu Lys Leu Leu Tyr Gly Leu Ala Ser Val Lys Asn Val Thr Leu Leu 
            820                 825                 830         


Ser Arg Tyr Leu Asp Leu Leu Lys Asp Thr Asn Leu Ile Lys Thr Gln 
        835                 840                 845             


Asp Val Phe Thr Val Ile Arg Tyr Ile Ser Tyr Asn Ser Tyr Gly Lys 
    850                 855                 860                 


Asn Met Ala Trp Asn Trp Ile Gln Leu Asn Trp Asp Tyr Leu Val Asn 
865                 870                 875                 880 


Arg Tyr Thr Leu Asn Asn Arg Asn Leu Gly Arg Ile Val Thr Ile Ala 
                885                 890                 895     


Glu Pro Phe Asn Thr Glu Leu Gln Leu Trp Gln Met Glu Ser Phe Phe 
            900                 905                 910         


Ala Lys Tyr Pro Gln Ala Gly Ala Gly Glu Lys Pro Arg Glu Gln Val 
        915                 920                 925             


Leu Glu Thr Val Lys Asn Asn Ile Glu Trp Leu Lys Gln His Arg Asn 
    930                 935                 940                 


Thr Ile Arg Glu Trp Phe Phe Asn Leu Leu Glu Ser Gly 
945                 950                 955         


<210>  109
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Asn Leu Ala Ile Ser Ile Ala Leu Leu Leu Thr Val Leu Gln Val 
1               5                   10                  15      


Ser Arg Gly Gln Lys Val Thr Ser Leu Thr Ala Cys Leu Val Asp Gln 
            20                  25                  30          


Ser Leu Arg Leu Asp Cys Arg His Glu Asn Thr Ser Ser Ser Pro Ile 
        35                  40                  45              


Gln Tyr Glu Phe Ser Leu Thr Arg Glu Thr Lys Lys His Val Leu Phe 
    50                  55                  60                  


Gly Thr Val Gly Val Pro Glu His Thr Tyr Arg Ser Arg Thr Asn Phe 
65                  70                  75                  80  


Thr Ser Lys Tyr Asn Met Lys Val Leu Tyr Leu Ser Ala Phe Thr Ser 
                85                  90                  95      


Lys Asp Glu Gly Thr Tyr Thr Cys Ala Leu His His Ser Gly His Ser 
            100                 105                 110         


Pro Pro Ile Ser Ser Gln Asn Val Thr Val Leu Arg Asp Lys Leu Val 
        115                 120                 125             


Lys Cys Glu Gly Ile Ser Leu Leu Ala Gln Asn Thr Ser Trp Leu Leu 
    130                 135                 140                 


Leu Leu Leu Leu Ser Leu Ser Leu Leu Gln Ala Thr Asp Phe Met Ser 
145                 150                 155                 160 


Leu 
    


