                         SEQUENCE LISTING

<110>  Isis Pharmaceuticals, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION

<130>  BIOL0248WO

<150>  61/818,442
<151>  2013-05-01

<150>  61/823,826
<151>  2013-05-15

<150>  61/843,887
<151>  2013-07-08

<150>  61/871,673
<151>  2013-08-29

<150>  61/880,790
<151>  2013-09-20

<150>  61/976,991
<151>  2014-04-08

<150>  61/986,867
<151>  2014-04-30  

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  3182
<212>  DNA
<213>  Hepatitis B virus

<400>  1
aattccacaa cctttcacca aactctgcaa gatcccagag tgagaggcct gtatttccct       60

gctggtggct ccagttcagg agcagtaaac cctgttccga ctactgcctc tcccttatcg      120

tcaatcttct cgaggattgg ggaccctgcg ctgaacatgg agaacatcac atcaggattc      180

ctaggacccc ttctcgtgtt acaggcgggg tttttcttgt tgacaagaat cctcacaata      240

ccgcagagtc tagactcgtg gtggacttct ctcaattttc tagggggaac taccgtgtgt      300

cttggccaaa attcgcagtc cccaacctcc aatcactcac caacctcctg tcctccaact      360

tgtcctggtt atcgctggat gtgtctgcgg cgttttatca tcttcctctt catcctgctg      420

ctatgcctca tcttcttgtt ggttcttctg gactatcaag gtatgttgcc cgtttgtcct      480

ctaattccag gatcctcaac caccagcacg ggaccatgcc gaacctgcat gactactgct      540

caaggaacct ctatgtatcc ctcctgttgc tgtaccaaac cttcggacgg aaattgcacc      600

tgtattccca tcccatcatc ctgggctttc ggaaaattcc tatgggagtg ggcctcagcc      660

cgtttctcct ggctcagttt actagtgcca tttgttcagt ggttcgtagg gctttccccc      720

actgtttggc tttcagttat atggatgatg tggtattggg ggccaagtct gtacagcatc      780

ttgagtccct ttttaccgct gttaccaatt ttcttttgtc tttgggtata catttaaacc      840

ctaacaaaac aaagagatgg ggttactctc tgaattttat gggttatgtc attggaagtt      900

atgggtcctt gccacaagaa cacatcatac aaaaaatcaa agaatgtttt agaaaacttc      960

ctattaacag gcctattgat tggaaagtat gtcaacgaat tgtgggtctt ttgggttttg     1020

ctgccccatt tacacaatgt ggttatcctg cgttaatgcc cttgtatgca tgtattcaat     1080

ctaagcaggc tttcactttc tcgccaactt acaaggcctt tctgtgtaaa caatacctga     1140

acctttaccc cgttgcccgg caacggccag gtctgtgcca agtgtttgct gacgcaaccc     1200

ccactggctg gggcttggtc atgggccatc agcgcgtgcg tggaaccttt tcggctcctc     1260

tgccgatcca tactgcggaa ctcctagccg cttgttttgc tcgcagcagg tctggagcaa     1320

acattatcgg gactgataac tctgttgtcc tctcccgcaa atatacatcg tatccatggc     1380

tgctaggctg tgctgccaac tggatcctgc gcgggacgtc ctttgtttac gtcccgtcgg     1440

cgctgaatcc tgcggacgac ccttctcggg gtcgcttggg actctctcgt ccccttctcc     1500

gtctgccgtt ccgaccgacc acggggcgca cctctcttta cgcggactcc ccgtctgtgc     1560

cttctcatct gccggaccgt gtgcacttcg cttcacctct gcacgtcgca tggagaccac     1620

cgtgaacgcc caccgaatgt tgcccaaggt cttacataag aggactcttg gactctctgc     1680

aatgtcaacg accgaccttg aggcatactt caaagactgt ttgtttaaag actgggagga     1740

gttgggggag gagattagat taaaggtctt tgtactagga ggctgtaggc ataaattggt     1800

ctgcgcacca gcaccatgca actttttcac ctctgcctaa tcatctcttg ttcatgtcct     1860

actgttcaag cctccaagct gtgccttggg tggctttggg gcatggacat cgacccttat     1920

aaagaatttg gagctactgt ggagttactc tcgtttttgc cttctgactt ctttccttca     1980

gtacgagatc ttctagatac cgcctcagct ctgtatcggg aagccttaga gtctcctgag     2040

cattgttcac ctcaccatac tgcactcagg caagcaattc tttgctgggg ggaactaatg     2100

actctagcta cctgggtggg tgttaatttg gaagatccag catctagaga cctagtagtc     2160

agttatgtca acactaatat gggcctaaag ttcaggcaac tcttgtggtt tcacatttct     2220

tgtctcactt ttggaagaga aaccgttata gagtatttgg tgtctttcgg agtgtggatt     2280

cgcactcctc cagcttatag accaccaaat gcccctatcc tatcaacact tccggaaact     2340

actgttgtta gacgacgagg caggtcccct agaagaagaa ctccctcgcc tcgcagacga     2400

aggtctcaat cgccgcgtcg cagaagatct caatctcggg aacctcaatg ttagtattcc     2460

ttggactcat aaggtgggga actttactgg tctttattct tctactgtac ctgtctttaa     2520

tcctcattgg aaaacaccat cttttcctaa tatacattta caccaagaca ttatcaaaaa     2580

atgtgaacag tttgtaggcc cacttacagt taatgagaaa agaagattgc aattgattat     2640

gcctgctagg ttttatccaa aggttaccaa atatttacca ttggataagg gtattaaacc     2700

ttattatcca gaacatctag ttaatcatta cttccaaact agacactatt tacacactct     2760

atggaaggcg ggtatattat ataagagaga aacaacacat agcgcctcat tttgtgggtc     2820

accatattct tgggaacaag atctacagca tggggcagaa tctttccacc agcaatcctc     2880

tgggattctt tcccgaccac cagttggatc cagccttcag agcaaacaca gcaaatccag     2940

attgggactt caatcccaac aaggacacct ggccagacgc caacaaggta ggagctggag     3000

cattcgggct gggtttcacc ccaccgcacg gaggcctttt ggggtggagc cctcaggctc     3060

agggcatact acaaactttg ccagcaaatc cgcctcctgc ctccaccaat cgccagacag     3120

gaaggcagcc taccccgctg tctccacctt tgagaaacac tcatcctcag gccatgcagt     3180

gg                                                                    3182


<210>  2
<211>  938
<212>  DNA
<213>  Homo sapiens

<400>  2
gttgactaag tcaataatca gaatcagcag gtttgcagtc agattggcag ggataagcag       60

cctagctcag gagaagtgag tataaaagcc ccaggctggg agcagccatc acagaagtcc      120

actcattctt ggcaggatgg cttctcatcg tctgctcctc ctctgccttg ctggactggt      180

atttgtgtct gaggctggcc ctacgggcac cggtgaatcc aagtgtcctc tgatggtcaa      240

agttctagat gctgtccgag gcagtcctgc catcaatgtg gccgtgcatg tgttcagaaa      300

ggctgctgat gacacctggg agccatttgc ctctgggaaa accagtgagt ctggagagct      360

gcatgggctc acaactgagg aggaatttgt agaagggata tacaaagtgg aaatagacac      420

caaatcttac tggaaggcac ttggcatctc cccattccat gagcatgcag aggtggtatt      480

cacagccaac gactccggcc cccgccgcta caccattgcc gccctgctga gcccctactc      540

ctattccacc acggctgtcg tcaccaatcc caaggaatga gggacttctc ctccagtgga      600

cctgaaggac gagggatggg atttcatgta accaagagta ttccattttt actaaagcag      660

tgttttcacc tcatatgcta tgttagaagt ccaggcagag acaataaaac attcctgtga      720

aaggcacttt tcattccact ttaacttgat tttttaaatt cccttattgt cccttccaaa      780

aaaaagagaa tcaaaatttt acaaagaatc aaaggaattc tagaaagtat ctgggcagaa      840

cgctaggaga gatccaaatt tccattgtct tgcaagcaaa gcacgtatta aatatgatct      900

gcagccatta aaaagacaca ttctgtaaaa aaaaaaaa                              938


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
gcagaggtga agcgaagtgc                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
ccaatttatg cctacagcct                                                   20


<210>  5
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
ggcatagcag caggatg                                                      17


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
aggagttccg cagtatggat                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
gtgaagcgaa gtgcacacgg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
gtgcagaggt gaagcgaagt                                                   20


<210>  9
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
aggtgaagcg aagtgc                                                       16


<210>  10
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
tccgcagtat ggatcg                                                       16


<210>  11
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
aatttatgcc tacagcct                                                     18


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
tcttggttac atgaaatccc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
cttggttaca tgaaatccca                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
ggaatactct tggttacatg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
tggaatactc ttggttacat                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
ttttattgtc tctgcctgga                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
gaatgtttta ttgtctctgc                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
aggaatgttt tattgtctct                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
acaggaatgt tttattgtct                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
agcttcttgt ccagctttat                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
agcttcttgt ccagctttat a                                                 21


<210>  22
<211>  14
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
tcagtcatga cttc                                                         14


<210>  23
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
tcagtcatga cttca                                                        15


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
gctgattaga gagaggtccc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
tcccatttca ggagacctgg                                                   20


<210>  26
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
atcagtcatg acttc                                                        15


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
cggtgcaagg cttaggaatt                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
gcttcagtca tgacttcctt                                                   20


<210>  29
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
gcttcagtca tgacttcctt a                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
agcttcagtc atgacttcct t                                                 21


<210>  31
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
tggtaatcca ctttcagagg                                                   20


<210>  32
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  32
tggtaatcca ctttcagagg a                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  33
tgcttcagtc atgacttcct t                                                 21


<210>  34
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
cactgatttt tgcccaggat                                                   20


<210>  35
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
cactgatttt tgcccaggat a                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
aagcttcttg tccagcttta t                                                 21


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  37
acccaattca gaaggaagga                                                   20


<210>  38
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  38
acccaattca gaaggaagga a                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  39
aacccaattc agaaggaagg a                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
atggtaatcc actttcagag g                                                 21


<210>  41
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  41
tcttggttac atgaaatccc                                                   20


<210>  42
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  42
tcttggttac atgaaatccc a                                                 21


<210>  43
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  43
attcactttc ataatgctgg                                                   20


<210>  44
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  44
attcactttc ataatgctgg a                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  45
atcttggtta catgaaatcc c                                                 21


<210>  46
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  46
atgcatggtg atgcttctga                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  47
cagctttatt agggacagca                                                   20


<210>  48
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  48
cagctttatt agggacagca a                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  49
acagctttat tagggacagc a                                                 21


<210>  50
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  50
ttcagtcatg acttcc                                                       16


<210>  51
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  bases at these positions are RNA

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  bases at these positions are RNA

<400>  51
gcuucagtca tgactucc                                                     18


<210>  52
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  52
tgctccgttg gtgcttgttc a                                                 21


<210>  53
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  53
tgctccgttg gtgcttgttc                                                   20


