                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF 
       INFLAMMATORY BOWEL DISEASES

<130>  BIO13127 DE SAINT BASILE / MC

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  5167
<212>  DNA
<213>  Homo sapiens

<400>  1
ggccaggggc gggtccgcag ctggcggcgc cggggcccgg ggcggaggct gtggcagcag     60

ctgcagcggc ggcggcggcg gcagcgccag gagctgctac agcagaggcg gaggttgctc    120

ctgtacgcgt acgggccgct cggccggagc cgcagcccgg aggcgccggg cggtgcgctg    180

ggagctgctg gtgctgctgc tgctgctgct gcccaccctc cgccgcccgg gcccccgctg    240

ccgcccgggc cccggctgcc gtctgcgccc ccgtcgaccc cgcccgcgag tgcgccccag    300

ccaggacgcc gcccccggcc gggtctccac ttcttggccg caccttccat gacagcgccc    360

gcgagaagat ggctgcgaag ggcgcgcacg gctcctacct gaaggtggag agcgagctgg    420

agcgctgccg cgccgagggc cactgggacc gcatgccgga gctggtccgg cagctgcaga    480

cgctgagcat gcccggcggc ggaggtaaca ggcgaggcag cccgagcgca gcgttcacct    540

ttccggacac cgatgacttt gggaaattgc tgctggctga ggccctcctg gagcagtgtt    600

tgaaggagaa ccatgccaaa ataaaagact ccatgccttt gctggagaag aatgagccga    660

agatgagcga agccaaaaat tatctaagca gtatccttaa ccatgggagg ctctcgccac    720

agtacatgtg tgaggccatg ctgatcctgg gcaaactgca ttacgtggag ggctcatacc    780

gagatgccat cagcatgtac gcacgggccg ggattgatga catgtccatg gagaacaagc    840

ccctgtatca gatgcggctg ctgtcggagg cttttgtcat caaaggcctc tctctggaac    900

gcctacccaa ctccatcgcc tcccgcttcc gcctgacaga gagggaggag gaagtgatca    960

cctgttttga gagggcctcc tggatcgctc aggtgttcct gcaggaattg gagaagacca   1020

caaataacag cacgtcgagg catctgaaag gctgtcaccc gcttgactat gagctcacct   1080

acttcctgga agctgccctc cagagcgcct atgtgaaaaa cctgaagaag gggaacatcg   1140

tgaagggcat gagagagctc cgggaggtgc tgcggactgt ggagaccaaa gcaactcaga   1200

acttcaaagt gatggcggcc aagcacctgg cgggggtcct gctgcactcc ctgagtgagg   1260

agtgctactg gagccccctg tcccaccctc tgcctgagtt catgggcaag gaggagagtt   1320

ctttcgccac tcaggccctg cggaaacctc acctctatga aggagacaac ctctactgcc   1380

ccaaggacaa catcgaggaa gccctcctgc tcctcctcat cagcgaatcc atggcaactc   1440

gagatgtggt gctgagccgg gtgccggagc aggaggagga ccggacagtg agcttgcaga   1500

atgccgcagc catctatgac ctcctgagca tcacgttggg cagaagggga cagtacgtca   1560

tgctctcgga gtgcctggag cgagccatga agtttgcgtt tggagaattt cacctttggt   1620

accaggtggc cctctccatg gtggcttgtg ggaagtcagc ctacgctgtg tccctgctgc   1680

gggagtgtgt gaagttgcgg ccctcggacc ccaccgtgcc cctgatggcc gcgaaggtct   1740

gcatcgggtc ccttcgctgg ctagaggaag cagagcactt tgccatgatg gtgatcagcc   1800

tcggagagga agccggggag ttcctcccca agggctacct ggctctgggt ctcacctata   1860

gcctgcaggc caccgacgcc accctgaagt ccaagcaaga tgaattgcac cggaaggcac   1920

tgcagacgct ggagagggct cagcagctgg cgcccagtga cccccaggtc atcctctatg   1980

tctcgctgca gctggccctc gtccgacaga tctccagtgc catggagcag ctgcaggagg   2040

ccctgaaggt acgcaaggat gatgcccacg ccctccacct gctggcactg ctcttctctg   2100

cccagaagca ccaccagcat gccctggatg ttgtcaacat ggccatcacc gagcaccctg   2160

agaacttcaa cctgatgttc accaaggtga agctggagca ggtgctgaaa ggcccagagg   2220

aagccctcgt gacctgcaga caagtgctga ggctgtggca gaccctgtac agcttctccc   2280

agctgggagg cctagaaaag gatggcagct tcggtgaggg cctcaccatg aagaagcaga   2340

gtggcatgca cctgactttg cctgatgccc atgatgcaga ctctggctcc cggcgggctt   2400

cgtccatcgc cgcctcccgg ctggaggagg ccatgtcaga gctgactatg ccctcttcgg   2460

tcctgaagca gggccccatg cagctgtgga ccacgctgga acagatctgg ctgcaggctg   2520

ctgagctgtt catggagcag cagcacctca aggaagcagg tttctgcatc caggaggcgg   2580

cgggcctctt ccccacttct cactcagtac tctatatgcg gggccggctg gctgaggtga   2640

agggcaacct ggaggaggcc aagcagctgt acaaggaggc gctcacggtg aacccagatg   2700

gcgtgcgcat catgcatagc ctgggtctga tgctgagtcg gctgggccac aagagcttgg   2760

cccagaaggt gcttcgtgat gccgtggaga ggcagagtac gtgccacgag gcgtggcagg   2820

gcctgggcga ggtgctgcag gcccagggcc agaacgaggc tgccgttgac tgcttcctca   2880

ccgcccttga gctggaggcc agcagccctg tactgccctt ctccatcatc cccagagagc   2940

tctgacgacg ctgcagccgc agggagggag gggctggcca gagggagagg cagcagggaa   3000

cgtgggtcag ggtggggcaa cagtggcatc aggtgcgggg cctcagggaa atacatcttt   3060

agtgaacgcc tctgcagctg cagccctcgt tctcttggct gggccaagag ggccttcctg   3120

gatttctttg ttggtgcctt gggaaacagt ctgacttgaa ccctaagtgc ctttggagag   3180

ttttgtggtg accagacttg ctccccaaga gctgggcagc ggggagcctc acagctgtcc   3240

ttcaccctca cccatgcctc tggcttggag tctgggtggg gggttctcac tccccactct   3300

cagcacagta cagacttctg gatctctctc aggtcttgcc cagggcggtc acaatgtgaa   3360

gaaactgcgg gcaagtggga agactatgag atttctgggt tcccttctca gacttggagt   3420

tagtagatga ttcctgcatt gcccctgctt gccctctgag accagctggg ccccaccttg   3480

ctctttcccc ctgctaccaa gtgcctttgg ggtctgacca ggggtactga gcaccggccc   3540

taacacttcc atctccaccc accccatctc cctggcgatg tgctccagcc caagcagcct   3600

ccgtaggctt tagatcctgt ggttgctaga tccagtcctt tctaataccc tgagtcaaca   3660

cattactcct gcaggtctta ggctacaatg caggtccctt gagggccacc aacatggagg   3720

taggcagttt ctaggactgt ccccagtaca tctcaccacc cacagccctt tttttgcctt   3780

gattcgagcc tcaccctggc cttttggctt cccctgcctg agagagacct gaggagggga   3840

cagagcccag cccctctcct gtggctgagc aggcctctgt gtccatgaca cctgtcttcc   3900

gggcctgggg gctgtgggtg tatgtcctcc ctactggctt ccccggcccc tgctgcatga   3960

tgctcttgga actcttctcc aaggagtcag tcccccaggc ctatcagggg atccttttgt   4020

atctgcactt tgggttttag tttcaaagct ccatcaggta cagcttgcat ttcaggatgt   4080

gtggaaagct cgggtgaggg ctgccctggt tcatcatagc tccaccttcc tcggaaggag   4140

tgggctgttg gagacccccc atccatggca cactagctca gcactgcatt tcccgagatg   4200

attcccaaga cagctggtgc ctcctggctt tcctgtgcca ggccaagggg caccacagag   4260

gaccctggat cctttgcctc ttcttggttg aaggatctct atgtatgtgt gtatataaat   4320

atagtttttt atctatatat ataaaataga gatctatttt ttttctggaa ttctgttaga   4380

aaagtaaaga aaaagcaaat gctgttggtt tatctcaggg tgcccaaagt ggttatagtc   4440

aatttttggt actaggaaag gcacccaatg catttcctga cttttaagca tttccttgtt   4500

ggaagcagca gagggccagg ccaagttgct gacagtgact ttgcaggttg aataaagaaa   4560

cccttggagg ggaagcaggc ttgtctgaag cagcatgtat attcactggg catgtagctc   4620

ccacaccagc cttgagccag gccctggaca ggaggggctg ttgcaggatg agggaggcca   4680

gagaaggcat cgaagccaag acctgggccc acctggggag ggatgtggga aaggaaggat   4740

gggagggagg accctctggg aaaatgtgga tttgagctgg tgagagtgtt gctaaggctg   4800

ggctaaagcc tggagagggt aggaggaggc aagaggggtc caggcagggc tgatcctggc   4860

ctctgacctg tccagggcga cccctgaagc ccctgctgcc tctgggcatt gctgggagag   4920

gccaaggcag gactcacgtc tgaacagaga tcccctcggg cattgctgat gggccacctt   4980

cagctgcagg gaagaagcct aggagaggag gcatgggagg gacctgggcc ttgttcagat   5040

tggccacctc tgctgagaag tccataccag tacaccccta ataagttatg ccacatacca   5100

acgtactgtg gatattataa cctgcattaa aacaactcta aagaacgctg ctcatttaaa   5160

aaaaaaa                                                             5167


<210>  2
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Lys Gly Ala His Gly Ser Tyr Leu Lys Val Glu Ser Glu 
1               5                   10                  15      


Leu Glu Arg Cys Arg Ala Glu Gly His Trp Asp Arg Met Pro Glu Leu 
            20                  25                  30          


Val Arg Gln Leu Gln Thr Leu Ser Met Pro Gly Gly Gly Gly Asn Arg 
        35                  40                  45              


Arg Gly Ser Pro Ser Ala Ala Phe Thr Phe Pro Asp Thr Asp Asp Phe 
    50                  55                  60                  


Gly Lys Leu Leu Leu Ala Glu Ala Leu Leu Glu Gln Cys Leu Lys Glu 
65                  70                  75                  80  


Asn His Ala Lys Ile Lys Asp Ser Met Pro Leu Leu Glu Lys Asn Glu 
                85                  90                  95      


Pro Lys Met Ser Glu Ala Lys Asn Tyr Leu Ser Ser Ile Leu Asn His 
            100                 105                 110         


Gly Arg Leu Ser Pro Gln Tyr Met Cys Glu Ala Met Leu Ile Leu Gly 
        115                 120                 125             


Lys Leu His Tyr Val Glu Gly Ser Tyr Arg Asp Ala Ile Ser Met Tyr 
    130                 135                 140                 


Ala Arg Ala Gly Ile Asp Asp Met Ser Met Glu Asn Lys Pro Leu Tyr 
145                 150                 155                 160 


Gln Met Arg Leu Leu Ser Glu Ala Phe Val Ile Lys Gly Leu Ser Leu 
                165                 170                 175     


Glu Arg Leu Pro Asn Ser Ile Ala Ser Arg Phe Arg Leu Thr Glu Arg 
            180                 185                 190         


Glu Glu Glu Val Ile Thr Cys Phe Glu Arg Ala Ser Trp Ile Ala Gln 
        195                 200                 205             


Val Phe Leu Gln Glu Leu Glu Lys Thr Thr Asn Asn Ser Thr Ser Arg 
    210                 215                 220                 


His Leu Lys Gly Cys His Pro Leu Asp Tyr Glu Leu Thr Tyr Phe Leu 
225                 230                 235                 240 


Glu Ala Ala Leu Gln Ser Ala Tyr Val Lys Asn Leu Lys Lys Gly Asn 
                245                 250                 255     


Ile Val Lys Gly Met Arg Glu Leu Arg Glu Val Leu Arg Thr Val Glu 
            260                 265                 270         


Thr Lys Ala Thr Gln Asn Phe Lys Val Met Ala Ala Lys His Leu Ala 
        275                 280                 285             


Gly Val Leu Leu His Ser Leu Ser Glu Glu Cys Tyr Trp Ser Pro Leu 
    290                 295                 300                 


Ser His Pro Leu Pro Glu Phe Met Gly Lys Glu Glu Ser Ser Phe Ala 
305                 310                 315                 320 


Thr Gln Ala Leu Arg Lys Pro His Leu Tyr Glu Gly Asp Asn Leu Tyr 
                325                 330                 335     


Cys Pro Lys Asp Asn Ile Glu Glu Ala Leu Leu Leu Leu Leu Ile Ser 
            340                 345                 350         


Glu Ser Met Ala Thr Arg Asp Val Val Leu Ser Arg Val Pro Glu Gln 
        355                 360                 365             


Glu Glu Asp Arg Thr Val Ser Leu Gln Asn Ala Ala Ala Ile Tyr Asp 
    370                 375                 380                 


Leu Leu Ser Ile Thr Leu Gly Arg Arg Gly Gln Tyr Val Met Leu Ser 
385                 390                 395                 400 


Glu Cys Leu Glu Arg Ala Met Lys Phe Ala Phe Gly Glu Phe His Leu 
                405                 410                 415     


Trp Tyr Gln Val Ala Leu Ser Met Val Ala Cys Gly Lys Ser Ala Tyr 
            420                 425                 430         


Ala Val Ser Leu Leu Arg Glu Cys Val Lys Leu Arg Pro Ser Asp Pro 
        435                 440                 445             


Thr Val Pro Leu Met Ala Ala Lys Val Cys Ile Gly Ser Leu Arg Trp 
    450                 455                 460                 


Leu Glu Glu Ala Glu His Phe Ala Met Met Val Ile Ser Leu Gly Glu 
465                 470                 475                 480 


Glu Ala Gly Glu Phe Leu Pro Lys Gly Tyr Leu Ala Leu Gly Leu Thr 
                485                 490                 495     


Tyr Ser Leu Gln Ala Thr Asp Ala Thr Leu Lys Ser Lys Gln Asp Glu 
            500                 505                 510         


Leu His Arg Lys Ala Leu Gln Thr Leu Glu Arg Ala Gln Gln Leu Ala 
        515                 520                 525             


Pro Ser Asp Pro Gln Val Ile Leu Tyr Val Ser Leu Gln Leu Ala Leu 
    530                 535                 540                 


Val Arg Gln Ile Ser Ser Ala Met Glu Gln Leu Gln Glu Ala Leu Lys 
545                 550                 555                 560 


Val Arg Lys Asp Asp Ala His Ala Leu His Leu Leu Ala Leu Leu Phe 
                565                 570                 575     


Ser Ala Gln Lys His His Gln His Ala Leu Asp Val Val Asn Met Ala 
            580                 585                 590         


Ile Thr Glu His Pro Glu Asn Phe Asn Leu Met Phe Thr Lys Val Lys 
        595                 600                 605             


Leu Glu Gln Val Leu Lys Gly Pro Glu Glu Ala Leu Val Thr Cys Arg 
    610                 615                 620                 


Gln Val Leu Arg Leu Trp Gln Thr Leu Tyr Ser Phe Ser Gln Leu Gly 
625                 630                 635                 640 


Gly Leu Glu Lys Asp Gly Ser Phe Gly Glu Gly Leu Thr Met Lys Lys 
                645                 650                 655     


Gln Ser Gly Met His Leu Thr Leu Pro Asp Ala His Asp Ala Asp Ser 
            660                 665                 670         


Gly Ser Arg Arg Ala Ser Ser Ile Ala Ala Ser Arg Leu Glu Glu Ala 
        675                 680                 685             


Met Ser Glu Leu Thr Met Pro Ser Ser Val Leu Lys Gln Gly Pro Met 
    690                 695                 700                 


Gln Leu Trp Thr Thr Leu Glu Gln Ile Trp Leu Gln Ala Ala Glu Leu 
705                 710                 715                 720 


Phe Met Glu Gln Gln His Leu Lys Glu Ala Gly Phe Cys Ile Gln Glu 
                725                 730                 735     


Ala Ala Gly Leu Phe Pro Thr Ser His Ser Val Leu Tyr Met Arg Gly 
            740                 745                 750         


Arg Leu Ala Glu Val Lys Gly Asn Leu Glu Glu Ala Lys Gln Leu Tyr 
        755                 760                 765             


Lys Glu Ala Leu Thr Val Asn Pro Asp Gly Val Arg Ile Met His Ser 
    770                 775                 780                 


Leu Gly Leu Met Leu Ser Arg Leu Gly His Lys Ser Leu Ala Gln Lys 
785                 790                 795                 800 


Val Leu Arg Asp Ala Val Glu Arg Gln Ser Thr Cys His Glu Ala Trp 
                805                 810                 815     


Gln Gly Leu Gly Glu Val Leu Gln Ala Gln Gly Gln Asn Glu Ala Ala 
            820                 825                 830         


Val Asp Cys Phe Leu Thr Ala Leu Glu Leu Glu Ala Ser Ser Pro Val 
        835                 840                 845             


Leu Pro Phe Ser Ile Ile Pro Arg Glu Leu 
    850                 855             


<210>  3
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  3
aggaattcca tggctgcgaa gggcgcgcac ggc                                  33


<210>  4
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  4
ggggatccct cagagctctc tggggatgat gg                                   32


