                         SEQUENCE LISTING

<110>  Ares trading S.A.
 
<120>  Monoclonal antibody directed against CXCR5

<130>  P12/127

<150>  EP13166251.2
<151>  2013-05-02

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAbs 40C01  and 12A01 

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          

Val Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              

Ser Gly Ile Ser Pro Ser Gly Gly Val Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ile Arg Lys Glu Met Thr Thr Ile Ser Tyr Phe Phe Asp Tyr 
            100                 105                 110         

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  2
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 40C01 

<400>  2

Asp Ile Gln Met Thr Arg Ala Pro Asp Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Asp Ile Tyr 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              

His Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Ala 
65                  70                  75                  80  

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser His Asn Ser Ala Val Val 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 40C01-VH1 

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          

Val Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Ser Pro Ser Gly Gly Val Thr Arg Tyr Ala Ala Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ile Arg Lys Glu Met Thr Thr Ile Ser Tyr Phe Phe Asp Tyr 
            100                 105                 110         

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  4
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 40C01-VH2 

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Ser 
            20                  25                  30          

Val Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Ser Pro Ser Gly Gly Val Thr Arg Tyr Ala Ala Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ile Arg Lys Glu Lys Thr Thr Ile Ser Tyr Phe Phe Asp Tyr 
            100                 105                 110         

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  5
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 40C01-Vk1 

<400>  5

Asp Ile Gln Met Thr Lys Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Asp Ala Tyr 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser His Asn Ser Ala Val Val 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 40C01-Vk2 

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Asp Ala Tyr 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser His Asn Ser Ala Val Val 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  7
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 40C01-Vk3 

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Asp Ala Tyr 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser His Asn Ala Ala Val Val 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  8
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1, heavy chain

<400>  8

Arg Tyr Val Met Val 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1, heavy chain

<400>  9

Arg Ser Val Met Val 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2, heavy chain

<400>  10

Gly Ile Ser Pro Ser Gly Gly Val Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      

Gly 
    


<210>  11
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2, heavy chain

<400>  11

Gly Ile Ser Pro Ser Gly Gly Val Thr Arg Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      

Gly 
    


<210>  12
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3, heavy chain

<400>  12

Ile Arg Lys Glu Met Thr Thr Ile Ser Tyr Phe Phe Asp Tyr 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3, heavy chain

<400>  13

Ile Arg Lys Glu Lys Thr Thr Ile Ser Tyr Phe Phe Asp Tyr 
1               5                   10                  


<210>  14
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1, light chain

<400>  14

Arg Ala Ser Gln Gly Val Asp Ile Tyr Val Ala 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1, light chain

<400>  15

Arg Ala Ser Gln Gly Val Asp Ala Tyr Val Ala 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2, light chain

<400>  16

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2, light chain

<400>  17

Ser Thr Ser Thr Leu Ala Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3, light chain

<400>  18

Gln Ser His Asn Ser Ala Val Val Thr 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3, light chain

<400>  19

Gln Ser His Asn Ala Ala Val Val Thr 
1               5                   


<210>  20
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR1, heavy chain

<400>  20

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  21
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR2, heavy chain

<400>  21

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val Ser 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR2, heavy chain

<400>  22

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  23
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR3, heavy chain

<400>  23

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  24
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR3, heavy chain

<400>  24

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  25
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR4, heavy chain

<400>  25

Tyr Trp Gly Gln Gly Thr Leu Val Thr 
1               5                   


<210>  26
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR1, light chain

<400>  26

Asp Ile Gln Met Thr Arg Ala Pro Asp Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  27
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR1, light chain

<400>  27

Asp Ile Gln Met Thr Lys Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  28
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR1, light chain

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  29
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR2, light chain

<400>  29

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met His 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR2, light chain

<400>  30

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR2, light chain

<400>  31

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  32
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR3, light chain

<400>  32

Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      

Leu Thr Ile Asn Ser Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  33
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR3, light chain

<400>  33

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      

Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  34
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  FR4, light chain

<400>  34

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  35
<211>  372
<212>  PRT
<213>  homo sapiens

<220>
<223>  Human CXCR5

<400>  35

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      

Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          

Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              

Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  

Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  

Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      

Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         

Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             

His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 

Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 

Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     

Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         

Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             

Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 

Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 

Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     

Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         

Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             

Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 

Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 

Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     

Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         

Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             

Leu Thr Thr Phe 
    370         


<210>  36
<211>  372
<212>  PRT
<213>  Macaca fascicularis

<220>
<223>  Macaca fascicularis CXCR5

<400>  36

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      

Leu Phe Leu Glu Phe Asp Lys Phe Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          

Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              

Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  

Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  

Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      

Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         

Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             

His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 

Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 

Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     

Gly Phe Leu Phe Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         

Ala His Pro Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             

Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 

Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 

Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     

Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         

Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Val Arg Leu Lys 
        275                 280                 285             

Ala Val Asp Asn Thr Cys Glu Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 

Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 

Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     

Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         

Pro Ser Trp Arg Lys Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             

Leu Thr Thr Phe 
    370         


<210>  37
<211>  372
<212>  PRT
<213>  Macaca mulatta

<220>
<223>  Macaca mulatta CXCR5

<400>  37

Met Asn Tyr Pro Leu Met Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      

Leu Phe Leu Glu Phe Asp Lys Phe Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          

Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              

Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  

Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  

Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      

Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         

Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             

His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 

Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 

Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     

Gly Phe Leu Phe Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         

Ala His Pro Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             

Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 

Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 

Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     

Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         

Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Val Arg Leu Lys 
        275                 280                 285             

Ala Val Asp Asn Thr Cys Glu Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 

Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 

Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     

Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         

Pro Ser Trp Arg Lys Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             

Leu Thr Thr Phe 
    370         


<210>  38
<211>  329
<212>  PRT
<213>  homo sapiens

<220>
<223> Heavy chain constant region - human IgG1 , allotype G1m(f) 

<400>  38

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 

Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  39
<211>  328
<212>  PRT
<213>  homo sapiens

<220>
<223> Heavy chain constant region - human IgG2 DI-NQ-HC2h subtype  

<400>  39

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Thr Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         

Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        115                 120                 125             

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 

Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
145                 150                 155                 160 

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                165                 170                 175     

Gln Ala Gln Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
            180                 185                 190         

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        195                 200                 205             

Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
    210                 215                 220                 

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
225                 230                 235                 240 

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            260                 265                 270         

Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        275                 280                 285             

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    290                 295                 300                 

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 

Lys Ser Leu Ser Leu Ser Pro Gly 
                325             


<210>  40
<211>  326
<212>  PRT
<213>  homo sapiens

<220>
<223>  Heavy chain constant region - human IgG4 S228P-R409K subtype 

<400>  40

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         

Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 

Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             

Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             

Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 

Leu Ser Leu Ser Leu Gly 
                325     


<210>  41
<211>  429
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for mAbs 40C01 and 12A01

<400>  41
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggc       60
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt      120
tcttgcgctg cttccggatt cactttctct cgttacgtta tggtttgggt tcgccaagct      180
cctggtaaag gtttggattg ggtttctggt atctctcctt ctggtggcgt tactcgttat      240
gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      300
ttgcagatga acagcttaag ggctgaggac accgccatgt attactgtgc acggatacga      360
aaggagatga ctacaatttc gtacttcttt gactactggg gccagggcac cctggtcacc      420
gtctcaagc                                                              429


<210>  42
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 40C01 

<400>  42
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
gacatccaga tgacccgggc accagactcc ctgtctgcct ctgtaggaga cagagtcacc      120
atcacttgcc gggcgagtca gggcgttgac atttatgttg cctggtatca gcagaaaccg      180
ggaaaagccc ctaaactcct gatgcatagt gcatccactt tggcatcagg ggtcccatct      240
cgcttcagtg gtcgtggatc tgggacggac ttcactctca ccatcaacag cctgcaggct      300
gaagatgttg ccacttacta ctgtcaaagt cataacagtg ccgtcgtcac tttcggccaa      360
gggacacgac tggagattaa a                                                381


<210>  43
<211>  426
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 40C01-VH1 

<400>  43
atggaatggt cctgggtgtt cctgttcttc ctgtccgtga ccaccggcgt gcactccgag       60
gtgcagctgc tggaatctgg gggcggactg gtgcagcctg gcggctccct gagactgtct      120
tgcgccgcct ccggcttcac cttctccaga tacgtgatgg tctgggtccg acaggcccct      180
ggcaagggcc tggaatgggt gtccggcatc tctcccagtg gcggcgtgac cagatacgcc      240
gcctctgtga agggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      300
cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgcgcccg gatcagaaaa      360
gagatgacca ccatctccta ctttttcgac tactggggcc agggcaccct ggtgacagtg      420

tcctcc                                                                 426


<210>  44
<211>  426
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 40C01-VH1 (codon optimized sequence)

<400>  44
atggaatggt cctgggtgtt cctgttcttc ctgtccgtga ccaccggcgt gcactccgag       60
gtgcagctgc tggaatctgg gggcggactg gtgcagcctg gcggctccct gagactgtct      120
tgcgccgcct ccggcttcac cttctccaga tacgtgatgg tctgggtccg acaggcccct      180
ggcaagggcc tggaatgggt gtccggcatc tctcccagtg gcggcgtgac cagatacgcc      240
gcctctgtga agggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      300
cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgcgcccg gatcagaaaa      360
gagatgacca ccatctccta ctttttcgac tactggggcc agggcaccct ggtgacagtg      420
tcctcc                                                                 426


<210>  45
<211>  426
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 40C01-VH2 

<400>  45
atggaatggt cctgggtgtt cctgttcttc ctgtccgtga ccaccggcgt gcactccgag       60
gtgcagctgc tggaatctgg gggcggactg gtgcagcctg gcggctccct gagactgtct      120
tgcgccgcct ccggcttcac cttctccaga tccgtgatgg tctgggtccg acaggcccct      180
ggcaagggcc tggaatgggt gtccggcatc tctcccagtg gcggcgtgac cagatacgcc      240
gcctctgtga agggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      300
cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgcgcccg gatcagaaaa      360
gagaagacca ccatctccta ctttttcgac tactggggcc agggcaccct ggtgacagtg      420
tcctcc                                                                 426


<210>  46
<211>  426
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 40C01-VH2 (codon optimized sequence)

<400>  46
atggaatggt cctgggtgtt cctgttcttc ctgagcgtga ccaccggcgt gcacagcgag       60
gtgcagctgc tggaaagcgg cggaggactg gtgcagcctg gaggcagcct gagactgtct      120
tgcgccgcca gcggcttcac cttcagcaga tccgtgatgg tgtgggtgcg ccaggcccct      180
ggcaagggac tggagtgggt gtccggcatc agcccctctg gcggcgtgac cagatacgcc      240
gccagcgtga agggccggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg      300
cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgcgccag aatccggaaa      360
gagaagacca ccatcagcta ctttttcgac tactggggac agggcaccct ggtgacagtg      420
tccagc                                                                 426


<210>  47
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 40C01-Vk1  

<400>  47
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
gacatccaga tgaccaagtc cccaagctcc ctgtctgcct ctgtaggaga cagagtcacc      120
atcacttgcc gggcgagtca gggcgttgac gcttatgttg cctggtatca gcagaaaccg      180
ggaaaagccc ctaaactcct gatctacagt acatccactt tggcatcagg ggtcccatct      240
cgcttcagtg gtagtggatc tgggacggac ttcactctca ccatcagcag cctgcagcct      300
gaagattttg ccacttacta ctgtcaaagt cataacagtg ccgtcgtcac tttcggccaa      360
gggacacgac tggagattaa a                                                381


<210>  48
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 40C01-Vk2  

<400>  48
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
gacatccaga tgacccagtc cccaagctcc ctgtctgcct ctgtaggaga cagagtcacc      120
atcacttgcc gggcgagtca gggcgttgac gcttatgttg cctggtatca gcagaaaccg      180
ggaaaagtcc ctaaactcct gatctacagt acatccactt tggcatcagg ggtcccatct      240
cgcttcagtg gtagtggatc tgggacggac ttcactctca ccatcagcag cctgcagcct      300
gaagatgtgg ccacttacta ctgtcaaagt cataacagtg ccgtcgtcac tttcggccaa      360
gggacacgac tggagattaa a                                                381


<210>  49
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 40C01-Vk3

<400>  49
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
gacatccaga tgacccagtc cccaagctcc ctgtctgcct ctgtaggaga cagagtcacc      120
atcacttgcc gggcgagtca gggcgttgac gcttatgttg cctggtatca gcagaaaccg      180
ggaaaagtcc ctaaactcct gatctacagt acatccactt tggcatcagg ggtcccatct      240
cgcttcagtg gtagtggatc tgggacggac ttcactctca ccatcagcag cctgcagcct      300
gaagatgtgg ccacttacta ctgtcaaagt cataacgctg ccgtcgtcac tttcggccaa      360
gggacacgac tggagattaa a                                                381


<210>  50
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 40C01-Vk3  (codon optimized sequence)

<400>  50
atggaaaccg acaccctgct cctctgggtg ctgctgctgt gggtgcccgg ctctaccggc       60
gacatccaga tgacccagtc cccctccagc ctgtccgcct ccgtgggcga cagagtgacc      120
atcacctgtc gggcctctca gggcgtggac gcctacgtgg cctggtatca gcagaaaccc      180
ggcaaggtgc ccaagctgct gatctactcc acctccaccc tggcctccgg cgtgccctcc      240
agattctccg gctctggctc cggcaccgac ttcaccctga ccatctccag cctgcagccc      300
gaggacgtgg ccacctacta ctgccagtcc cacaacgccg ccgtggtgac attcggccag      360
ggcacccggc tggaaatcaa g                                                381


<210>  51
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb optimized 42F03

<400>  51

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          

Arg Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Trp Ile Ser Pro Ser Gly Gly Ala Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Gly Leu Tyr Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         

Ser 
    


<210>  52
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb optimized 42F03

<400>  52

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Asn 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Ile Thr 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  53
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 80A10

<400>  53

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Met Tyr 
            20                  25                  30          

Val Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Arg Ser Ser Gly Gly Asp Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Gln Ser Arg Tyr Cys Asn Gly Gly Ser Cys Tyr Ser Arg Ala 
            100                 105                 110         

Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  54
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 80A10

<400>  54

Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser 
1               5                   10                  15      

Cys Phe Gly Ser Asn Ser Asn Ile Gly Ser Thr Tyr Ala Tyr Trp Tyr 
            20                  25                  30          

Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn 
        35                  40                  45              

Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  

Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
65                  70                  75                  80  

Asp Tyr Tyr Cys Ala Ala Trp Asp Val Asn Leu Ser Gly His Trp Val 
                85                  90                  95      

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105         


<210>  55
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 80A11

<400>  55

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          

Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Ser Ile Ser Pro Ser Gly Gly Met Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Leu Lys Phe Thr Ser Gly Arg Thr Phe Asp Ile Trp Gly Gln 
            100                 105                 110         

Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  56
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 80A11

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Ser Arg Val Pro Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  

Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Leu Ser Ser Ser Ser Pro Ser 
                85                  90                  95      

Trp Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  57
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 80B09

<400>  57

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          

Asn Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Val Ile Ser Pro Ser Gly Gly Arg Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg His Thr Ser Ile Thr Met Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         

Leu Val Thr Val Ser Ser 
        115             


<210>  58
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 80B09

<400>  58

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ser Tyr 
            20                  25                  30          

Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Arg Ala Pro Lys Val 
        35                  40                  45              

Met Ile Tyr Asp Val Thr Tyr Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Arg Lys Ser 
                85                  90                  95      

Ser Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  59
<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 80D11

<400>  59

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          

Trp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Ser Ile Ser Ser Ser Gly Gly Lys Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Thr Ala Gly Tyr Ser Ser Gly Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         

Val Ser Ser 
        115 


<210>  60
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 80D11

<400>  60

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          

Asn Tyr Leu Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Gly Val Ser Asn Arg Pro Ser Gly Val Ser Thr Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Thr 
                85                  90                  95      

Gly Thr Arg Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110 


<210>  61
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 42F03

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 
            20                  25                  30          

Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Tyr Ile Arg Ser Ser Gly Gly Phe Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Gly Leu Tyr Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         

Ser 
    


<210>  62
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 42F03

<400>  62

Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu 
1               5                   10                  15      

Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn Tyr 
            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              

Ser Gly Ala Ser Arg Arg Ala Thr Asp Ile Ala Asp Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Phe Pro Leu 
                85                  90                  95      

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  63
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain constant region  Lamba constant gene 3 

<400>  63

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      

Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          

Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              

Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  

Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  

Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      

Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  64
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain constant region  Kappa unique constant gene 

<400>  64

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  65
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 12A01

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Asp Ile Tyr 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Met 
        35                  40                  45              

His Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Ala 
65                  70                  75                  80  

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser His Asn Ser Ala Val Val 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  66
<211>  399
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb optimized 42F03 

<400>  66
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggc       60
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt      120
tcttgcgctg cttccggatt cactttctct cgttaccgta tggtgtgggt tcgccaagct      180
cctggtaaag gtttggagtg ggtttcttgg atctctcctt ctggtggcgc aactagctat      240
gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      300
ttgcagatga acagcttaag ggctgaggac actgcagtct actattgtgc gagaggcctg      360
taccggtggg gccagggaac cctggtcacc gtctcaagc                             399


<210>  67
<211>  378
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb optimized 42F03 

<400>  67
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
gagatcgtga tgacccagtc tccagccacc ctgtctgtgt ctccaggaga aagagccacc      120
ctctcctgca gggccagtca gagtgtgagt acaaacttag cctggtacca gcagaaacct      180
ggccaggctc ccaggctcct catctatggt gcatccagca gggccactgg catcccagcc      240
aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      300
gaagattttg cagtgtatta ctgtcagcag tatggtagct ccatcacttt cggcggaggg      360
accaaggtgg agatcaaa                                                    378


<210>  68
<211>  396
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 80A10

<400>  68
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
cagagcgaat tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc      120
tcttgttttg ggagcaactc caacatcgga agtacttatg catactggta ccagcaggtc      180
ccaggaacgg cccccaaact cctcatctac cggaataatc agcggccctc aggggtccct      240
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccattag tgggctccgg      300
tccgaggatg aggctgatta ttactgtgca gcatgggatg tcaacctgag tggtcattgg      360
gtgttcggcg gagggaccaa gctgaccgtc ctagga                                396


<210>  69
<211>  438
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 80A10

<400>  69
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggc       60
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt      120
tcttgcgctg cttccggatt cactttctct atgtacgtta tgaagtgggt tcgccaagct      180
cctggtaaag gtttggagtg ggtttctggt atccgttctt ctggtggcga tacttcttat      240
gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      300
ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc aagacagagc      360
cggtattgta atggtggtag ctgctactcg cgtgcttttg atatctgggg ccaagggaca      420
atggtcaccg tctcaagc                                                    438


<210>  70
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 80A11 

<400>  70
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
gacatccaga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc      120
ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      180
ggccaggctc ccaggctcct catctatggt gcgtccagca gggtccctgg cgtcccagac      240
aggttcactg gcagtgggtc tgagacagac ttcactctca ccatcaccag actggagcct      300
gaggattttg cagtctatta ctgtcagctg tctagtagct caccgtcgtg gacgttcggc      360
caggggacac gactggagat taaa                                             384


<210>  71
<211>  420
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 80A11

<400>  71
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggc       60
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt      120
tcttgcgctg cttccggatt cactttctct cgttacccta tgggttgggt tcgccaagct      180
cctggtaaag gtttggagtg ggtttcttct atctctcctt ctggtggcat gactcgttat      240
gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      300
ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagacttaaa      360
tttacgtcgg gcagaacttt tgatatctgg ggccaaggga caatggtcac cgtctcaagc      420


<210>  72
<211>  390
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 80B09 

<400>  72
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
cagagcgctt tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc      120
tcctgcactg gaaccagcag tgacattggg agttataatt atgtctcctg gtaccaacaa      180
cacccaggca gagcccccaa agtcatgatt tatgatgtca cttatcggcc ctcaggggtt      240
tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      300
caggctgagg acgaggctga ttattactgc ggctcatata gaaaaagcag cctttatgtc      360
ttcggaactg ggaccaaggt caccgtccta                                       390


<210>  73
<211>  414
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 80B09 

<400>  73
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggc       60
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt      120
tcttgcgctg cttccggatt cactttctct aagtacaata tgctttgggt tcgccaagct      180
cctggtaaag gtttggagtg ggtttctgtt atctctcctt ctggtggccg tacttcttat      240
gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      300
ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagacataca      360
agtattacta tgtttgacta ctggggccag ggaaccctgg tcaccgtctc aagc            414


<210>  74
<211>  390
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 80D11 

<400>  74
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
cagagcgctt tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc      120
tcctgcactg gaaccagcag tgacgttggt ggttataact atctctcctg gtaccaacag      180
cacccaggca aagcccccaa actcatgatt tatggggtca gtaatcggcc ctcaggagtt      240
tctactcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      300
caggctgagg acgaggctga ttattactgc agctcataca caagcaccgg cactcgggtt      360
ttcggcggag ggaccagact gaccgtccta                                       390


<210>  75
<211>  405
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 80D11 

<400>  75
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggc       60
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt      120
tcttgcgctg cttccggatt cactttctct cattactgga tgcagtgggt tcgccaagct      180
cctggtaaag gtttggagtg ggtttcttct atctcttctt ctggtggcaa gactcgttat      240
gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      300
ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc cacagccggg      360
tatagcagtg gatggggcca gggaaccctg gtcaccgtct caagc                      405


<210>  76
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 42F03 

<400>  76
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
gacatccaga tgacccagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120
ctctcctgca gggccagtca gagtgttagt aataactact tagcctggta ccagcagaaa      180
cctggccagg ctcccaggct cctcatctct ggtgcatccc gcagggccac tgacatcgca      240
gacaggttca gtggcagtgg gtctggcaca gacttcactc tcaccatcag caggctggag      300
cctgaagatt ttgcagtcta ttactgtcag cagtatgaca gttttcctct caccttcggc      360
ggagggacca aggtggagat caaa                                             384


<210>  77
<211>  399
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable heavy chain for the mAb 42F03 

<400>  77
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggc       60
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt      120
tcttgcgctg cttccggatt cactttctct tggtacccta tgacttgggt tcgccaagct      180
cctggtaaag gtttggagtg ggtttcttat atccgttctt ctggtggctt tactaagtat      240
gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      300
ttgcagatga acagcttaag ggctgaggac actgcagtct actattgtgc gagaggcctg      360
taccggtggg gccagggaac cctggtcacc gtctcaagc                             399


<210>  78
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  Variable light chain for the mAb 12A01 

<400>  78
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggt       60
gacatccaga tgacccagtc tccagactcc ctgtctgcct ctgtaggaga cagagtcacc      120
atcacttgcc gggcgagtca gggcgttgac atttatgttg cctggtatca gcagaaaccg      180
ggaaaagttc ctaaactcct gatgcatagt gcatccactt tggcatcagg ggtcccatct      240
cgcttcagtg gtcgtggatc tgggacggac ttcactctca ccatcaacag cctgcaggct      300
gaagatgttg ccacttacta ctgtcaaagt cataacagtg ccgtcgtcac tttcggccaa      360
gggacacgac tggagattaa a                                                381


<210>  79
<211>  452
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain for the mAb 40C01-VH1-IgG1

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          

Val Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Ser Pro Ser Gly Gly Val Thr Arg Tyr Ala Ala Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ile Arg Lys Glu Met Thr Thr Ile Ser Tyr Phe Phe Asp Tyr 
            100                 105                 110         

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             

Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 

Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 

Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     

Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         

Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             

Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 

Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 

Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         

Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 

Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     

Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         

Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     

Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             

Leu Ser Pro Gly 
    450         


<210>  80
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain for the mAb 40C01-VH1-IgG2_DI-NQ-HC2h-subtype

<400>  80

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          

Val Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Gly Ile Ser Pro Ser Gly Gly Val Thr Arg Tyr Ala Ala Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ile Arg Lys Glu Met Thr Thr Ile Ser Tyr Phe Phe Asp Tyr 
            100                 105                 110         

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             

Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 

Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 

Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     

Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         

Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             

Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Pro Lys 
    210                 215                 220                 

Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 

Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     

Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         

His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             

Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Ala Gln Ser Thr 
    290                 295                 300                 

Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
305                 310                 315                 320 

Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
                325                 330                 335     

Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         

Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             

Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 

Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 

Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     

Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         

Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             

Ser Pro Gly 
    450     


<210>  81
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain for the mAb 40C01-Vk3-c-Kappa

<400>  81

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Asp Ala Tyr 
            20                  25                  30          

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Ser Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser His Asn Ala Ala Val Val 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 

