                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> METHODS FOR MODULATING IMMUNE RESPONSES DURING CHRONIC IMMUNE 
      CONDITIONS BY TARGETING METALLOTHIONEINS

<130> 043214-077621-PCT

<140>
<141>

<150> 61/814,059
<151> 2013-04-19

<160> 92    

<170> PatentIn version 3.5

<210> 1
<211> 61
<212> PRT
<213> Homo sapiens

<400> 1
Met Asp Pro Asn Cys Ser Cys Ala Thr Gly Gly Ser Cys Thr Cys Thr 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Met Ser Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210> 2
<211> 468
<212> DNA
<213> Homo sapiens

<400> 2
accaagcctt ccacgtgcgc cttatagcct ctcaacttct tgcttgggat ctccaacctc       60

accgcggctc gaaatggacc ccaactgctc ctgcgccact ggtggctcct gcacctgcac      120

tggctcctgc aaatgcaaag agtgcaaatg cacctcctgc aagaagagct gctgctcctg      180

ctgccccatg agctgtgcca agtgtgccca gggctgcatc tgcaaagggg catcagagaa      240

gtgcagctgc tgtgcctgat gtccggacag ccctgctcga agatatagaa agagtgacct      300

gcacaaactt ggaatttttt ttccatacaa ccctgaccca tttactgtat tttttttaat      360

gaaatatgtg aatgataata aaagttgctg acttaaaaaa aaaaaaaaaa aaaaaaaaaa      420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                   468


<210> 3
<211> 61
<212> PRT
<213> Homo sapiens

<400> 3
Met Asp Pro Asn Cys Ser Cys Thr Thr Gly Gly Ser Cys Ala Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Cys 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Val Cys Lys Gly Ser Ser Glu Lys Cys Arg Cys Cys Ala 
    50                  55                  60      


<210> 4
<211> 403
<212> DNA
<213> Homo sapiens

<400> 4
cctgccctga cttctcatat cttgcctagg aactccaggc ttgtcttggc tccaaatgga       60

tcccaactgc tcctgcacca caggtggctc ctgtgcctgc gccggctcct gcaagtgcaa      120

agagtgcaaa tgtacctcct gcaagaagtg ctgctgctct tgctgccccg tgggctgtgc      180

caagtgtgcc cagggctgtg tctgcaaagg ctcatcagag aagtgccgct gctgtgcctg      240

atgttgggag agccctgctc ccagacataa atagagcaac cagtactaac ctggattttt      300

ttttttaact accctgaccg gtttgctaca ttcttttttc tattcaatat gtgaaagaca      360

ataaaacact tttgacttga aaaaaaaaaa aaaaaaaaaa aaa                        403


<210> 5
<211> 61
<212> PRT
<213> Homo sapiens

<400> 5
Met Asp Pro Asn Cys Ser Cys Ala Thr Gly Gly Ser Cys Thr Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Val Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210> 6
<211> 519
<212> DNA
<213> Homo sapiens

<400> 6
aggaacgcgg gcggtgcgga ctcagcgggc cgggtgcagg cgcggagctg ggcctctgcg       60

cccggcccga cctccgtcta taaatagagc agccagttgc agggctccat tctgctttcc      120

aactgcctga ctgcttgttc gtctcactgg tgtgagctcc agcatcccct ttgctcgaaa      180

tggaccccaa ctgctcttgc gccactggtg gctcctgcac gtgcgccggc tcctgcaagt      240

gcaaagagtg caaatgcacc tcctgcaaga agagctgctg ttcctgctgc cccgtgggct      300

gtgccaagtg tgcccagggc tgcgtctgca aaggggcatc ggagaagtgc agctgctgtg      360

cctgatgtgg gaacagctct tctcccagat gtaaatagaa caacctgcac aacctggatt      420

tttttaaaaa tacaacactg agccatttgc tgcatttctt tttatactaa atatgtgact      480

gacaataaaa acaattttga ctttaaaaaa aaaaaaaaa                             519


<210> 7
<211> 61
<212> PRT
<213> Homo sapiens

<400> 7
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Val Ser Cys Thr Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ser Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Val Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Asp 
    50                  55                  60      


<210> 8
<211> 456
<212> DNA
<213> Homo sapiens

<400> 8
gccccctccc ctgactatca aagcagcggc cggctgttgg ggtccaccac gccttccacc       60

tgccccactg cttcttcgct tctctcttgg aaagtccagt ctctcctcgg cttgcaatgg      120

accccaactg ctcctgcgcc gctggtgtct cctgcacctg cgctggttcc tgcaagtgca      180

aagagtgcaa atgcacctcc tgcaagaaga gctgctgctc ctgctgcccc gtgggctgta      240

gcaagtgtgc ccagggctgt gtttgcaaag gggcgtcaga gaagtgcagc tgctgcgact      300

gatgccagga caacctttct cccagatgta aacagagaga catgtacaaa cctggatttt      360

ttttttatac caccttgacc catttgctac attccttttc ctgtgaaata tgtgagtgat      420

aattaaacac tttagacctg aaaaaaaaaa aaaaaa                                456


<210> 9
<211> 61
<212> PRT
<213> Homo sapiens

<400> 9
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Val Ser Cys Thr Cys Ala 
1               5                   10                  15      


Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210> 10
<211> 396
<212> DNA
<213> Homo sapiens

<400> 10
actccgcctt ccacgtgcac ccactgcctc ttcccttctc gcttgggaac tctagtctcg       60

cctcgggttg caatggaccc caactgctcc tgtgccgctg gtgtctcctg cacctgcgcc      120

agctcctgca agtgcaaaga gtgcaaatgc acctcctgca agaagagctg ctgctcctgc      180

tgccctgtgg gctgtgccaa gtgtgcccaa ggctgcatct gcaaaggggc atcggagaag      240

tgcagctgct gcgcctgatg tcgggacagc cctgctccca agtacaaata gagtgacccg      300

taaaatctag gattttttgt tttttgctac aatcttgacc cctttgctac attccctttt      360

ttctgtgaaa tatgtgaata ataattaaac acttag                                396


<210> 11
<211> 61
<212> PRT
<213> Homo sapiens

<400> 11
Met Asp Pro Asn Cys Ser Cys Glu Ala Gly Gly Ser Cys Ala Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Lys Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Leu Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210> 12
<211> 397
<212> DNA
<213> Homo sapiens

<400> 12
accacgccct ccacgtgttc cactgcctct tctcttctcg cttgggaact ccagtctcac       60

ctcggcttgc aatggacccc aactgctcct gcgaggctgg tggctcctgc gcctgcgccg      120

gctcctgcaa gtgcaaaaag tgcaaatgca cctcctgcaa gaagagctgc tgctcctgtt      180

gccccctggg ctgtgccaag tgtgcccagg gctgcatctg caaaggggcg tcagagaagt      240

gcagctgctg tgcctgatgt cgggacagcc ctgctgtcag atgaaaacag aatgacacgt      300

aaaatccagg attttttttt tctacaactc cgactcattt gctacattcc tttttttctg      360

tgaaatatgt gaataataat taaacactta gacttga                               397


<210> 13
<211> 2005
<212> DNA
<213> Homo sapiens

<400> 13
aatgaagaag gtgagcaaga ggatggaccc ggatgcacac ggacccggga gaggcgaagc       60

tgaggacgac tgtgcggggg agggagaatg gagggggtgg ggacagcgcg accacctggg      120

aatgggaaat ggccctcagg gtggcagggg cggcgcgtac ctctggcagc atagcccctc      180

ccgcacgagc gggccccaaa agggcggtcc ccgggagccc accaggctgc actcagggga      240

tggtgcgcct gacccgcctg ctgcgcacag ctcaacccaa gaccgcaggc gccgcggatt      300

ccgcgtgggg gtgggtgaga agggtactct gcacccggcc ccctcttcta actataaatt      360

gagcttccgg ttcctagaat ccaccacgcc tcccacctgc cccactgctt cttctcctct      420

cccttaggaa ctctagcttc acctcgcttc gtaatggacc ccaattgctc ctgctccact      480

agtaagggat accgggtttc ggggctttag aatatccatt tccattccag aggatagaat      540

gtacccgggg caggagggag gtgcatgtta gctcttccta aagtggcctc ctttactttg      600

cacttctcgt gtttttccct gtcaagcgcc ttcattacca cttggaatgt tgccatcttc      660

ccagcgcccc cccacttttt ttttgttttt ttgtttgttt tttgttttgt tttgttttgt      720

tttgagacgg agtcttgccc tgtcgcccag gctggagtgc agtggcccga tcttggctca      780

ctgaaagctc cgcctcccgg gttcacgcca ttctcctgtc tcagcctgaa gagtagctgg      840

gactacaggc gcccgtcacc acgcccggct aattttttgt atttttggta gagacagggt      900

ttcaccgtgt tagccaggat ggtctcgatc tcctgacctc gtgatccgcc ctcctcggcc      960

tcccaaagtg gccctcccat ttttgaagcg agaagactga ggctcaaaac tgccaggtca     1020

cccagatagc cagtgggttc ccgggctggg acccagtgct ctgtccagca ttagagctgc     1080

ctgaggtgga tgggaggcag ggagcattgc ctcttaggga ttcctgatat aaggccttgg     1140

ggagtaaaat taggagggcg cctgcccatc ccagcctgtg gggaaaaaag gtggagctgg     1200

gcttccgtgt gcctgagtgg aacaaggtac caggtttccc atgcactgag caggaggatg     1260

ctgagggcct gctcctaacc ctgcagcaca ctcactgctc actgcctttt tctcttcacc     1320

tgcacctgca ccagctcctg caaatgcaga gagtgcaaat gcacctcctg caagacgagt     1380

gagtgagggg ccttccctgg gaatcgcagg gagcgggggt gctgggctga gtcagaggag     1440

ggatctcaga ttctgcaggc aggagcaggc tcatcactag cttcccacat cccctgaaac     1500

ggattcagga tcagagctgg aagaacatta gggatggttg attcctaccc aaccttcatt     1560

cttaacaatg gggaaactga ggtcacaaga atgtaccagc tggccaacca cagacctgat     1620

tcttgagggc ttttctcact gaaatgtatg gtcctgggga attgcccttc ctttgtcccc     1680

acagtcccag tcactgcctg tccagtcttc tgctctgtcc tggctctggt ggggctgagc     1740

aagtttttca caggaaggct ctcactccaa agatccacca ttgtctcaca gagcacacca     1800

tccggaccta aagctcctct gggtctgggt gcgagcttga gccaggccca ctgttggggc     1860

agagaggtgc ctgttcaagt ctgctgtgac ctgtcactct ccccttcttc cccaggctgc     1920

tgctcctgct gccccgtggg ctgtgccaag tgtgcccagg gatgtgtttg caaagggaca     1980

ctgacaagtg cagctgctgc tcctg                                           2005


<210> 14
<211> 408
<212> DNA
<213> Homo sapiens

<400> 14
cgctccacca cgccgtccac gtgcgccttg cggtctctcc atttatcgct tgagatctcc       60

agccttaccg cggctcgaaa tggaccccaa ctactcctgc accactggtg gctcctgcac      120

gtgcgccggc tcctgcaagt gcaaagagtg caaatgcacc tcctgcaaga agagctgctg      180

cttctgctgc cccatgggct gagccaagtg tgcccacggc tgcatctgca aagggacgtc      240

ggagaagtgc agctgctgtg cctgatgtgg gaacagctct tctcccagat gttaatagaa      300

caacctgcac aacctggatt ttttttttat acaatactga gccatttgct gcatttcttt      360

ttatattaaa tatgtgagtg acaataaaac aattttgact tgaatctt                   408


<210> 15
<211> 443
<212> DNA
<213> Homo sapiens

<400> 15
gtcccatctc cgcctgcaaa aggagcagct ggctccaggc tccaacgtgc cttccagctg       60

cctgactgcc tcttcgcctc tcccgtcatt tcttggctcg aaatggaccc caactgctcc      120

tgcgccactg ggggctcctg ctcctgtgcc agctcctgca agtgcaaaga gtgcaaatga      180

acctcctgca agaagagctg ctgctcctgc tgccccatgg gctgtgccaa gtgtgcccag      240

ggctgcgtct gcaaaggggc gtcggagaag tgcagctgct gtgcctgatg tggggacagc      300

cctgctccca gatgtaaaca gagcaacctg cacaaacctg gatttttttt tcatacaacc      360

ctgagcattt gctacattcc tttttctatt aaatatgtaa acgacaataa aacagttttg      420

acttgaaaaa aaaaaaaaaa aaa                                              443


<210> 16
<211> 61
<212> PRT
<213> Homo sapiens

<400> 16
Met Asp Pro Asn Cys Ser Cys Thr Thr Gly Val Ser Cys Ala Cys Thr 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala His Gly Cys 
        35                  40                  45              


Val Cys Lys Gly Thr Leu Glu Asn Cys Ser Cys Cys Ala 
    50                  55                  60      


<210> 17
<211> 464
<212> DNA
<213> Homo sapiens

<400> 17
ccctgagtag aaaagcagcc gcaggctgtg gcgctccacc acgccgtccg ggtgggccta       60

gcagtcgctc catttatcgc ttgagatctc cagccttacc gcggctcgaa atggacccca      120

actgctcctg caccactggt gtctcctgcg cctgcaccgg ctcctgcaag tgcaaagagt      180

gcaaatgcac ctcctgcaag aagagctgct gctcctgctg ccccgtgggc tgtgccaagt      240

gtgcccacgg ctgtgtctgc aaagggacgt tggagaactg cagctgctgt gcctgatgtg      300

ggaacagctc ttctcccaga tgttaataga acaagctgca caacctggat tttttttcaa      360

tacgatactg agccatttgc tgcatttctt tttatattaa atatgtgagt gacaataaaa      420

caattttgac ttgaatctta aaaaaaaaaa aaaaaaaaaa aaaa                       464


<210> 18
<211> 61
<212> PRT
<213> Homo sapiens

<400> 18
Met Asp Pro Asn Cys Ser Cys Ser Pro Val Gly Ser Cys Ala Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Thr Ser Asp Lys Cys Ser Cys Cys Ala 
    50                  55                  60      


<210> 19
<211> 468
<212> DNA
<213> Homo sapiens

<400> 19
accacgcttt tcatctgtcc cgctgcgtgt tttcctcttg atcgggaact cctgcttctc       60

cttgcctcga aatggacccc aactgctcct gctcgcctgt tggctcctgt gcctgtgccg      120

gctcctgcaa atgcaaagag tgcaaatgca cctcctgcaa gaagagctgc tgctcctgct      180

gccctgtggg ctgtgccaag tgtgcccagg gctgcatctg caaagggacg tcagacaagt      240

gcagctgctg tgcctgatgc caggacagct gtgctctcag atgtaaatag agcaacctat      300

ataaacctgg attttttttt tttttttttt tgtacaaccc tgacccgttt gctacatctt      360

tttttctatg aaatatgtga atggcaataa attcatctag actaaaaaaa aaaaaaaaaa      420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                   468


<210> 20
<211> 2025
<212> DNA
<213> Homo sapiens

<400> 20
tcaccttccc aggagtgggg aatggaaggg agggaggcag ggccgtgtgt ctgctctgtt       60

gctgtgaaca agacaaacgt ggccaaagga cctggctggc aatgcaggtg aggcaaaggt      120

cacatgggag gcttgtcctc tgcacacaac tccctcgctg cacttcccgc ctcagtccta      180

tctagggaca tgagcattag gccggggtag cacacagact cccacagagg cgaagctcag      240

gtcattggtg cggggtgctg ggctggggac accgtgacca cctaaggctt ggttcctgga      300

ccgctcaggg gcaggagtgg actccaatcc ccgggaaatt ctgtagggct gggattatag      360

cagggacgcc gcctaccgcc aaagcgagca ggagtcaaag ggcagccccc agggtgcgca      420

ctggcagcgc tagggaggat cctgcggcgg gcccgtctgc tgcgcacagc ccggccctga      480

accctagggc gcctctgaca ctgcgggagc gggggccaga cttggggcgg ggcctctgcg      540

cccggcaccc caccctaact acaaagccag aggtggctcc tgagctctgt tccccctccc      600

accggcttgc ctgcttcttc gcctctggct taggtactcc agcctcacct ggtctccaga      660

tggacctcaa ctgctcctgc gacactgata aaggatgccg ggtttcgggg ccttgggatc      720

tccattttca tgccagagga tagaatgtcc ctgcggcagg aggcaggtgc attttgagcc      780

ctacctgaag tggattattt tactttgtac ttctggtgct ttttctctta ccaatcgcct      840

ttattatcat cactgagaac attaccatag tcccagtgcc tcccatttct aaggcgagag      900

gaatgaggct caaaactgcc cctgctccgg gtcacctata ggccagaggt gtgctgagct      960

gggacctagt gctgtgtcca gcttttgagc tgcctgggct agtagggatg tgggaaacat     1020

tgcttcttca agatttccca ctgaggtccc cgtgtgctat gaaaaagagg gcgcctgccg     1080

atctgagcct ttgtggagaa aaggtggggc tgggcttcca tgtgcctgag tggaacaagg     1140

taccaggttt cccatgcact gagcaagagg atgctgaggg cctgctccta accctgcagc     1200

acactcaccg ctcactgcct ttttctcttt cctgcagctg ggtcctgcac ttatgccagc     1260

ttctgcaaat gcaaagagta caaatgcacc tcttgcaaga agagtgagtg tggggccttc     1320

cctgggaatc agggtgctgg gcagagtcag aggagggaac cgagagctca gcaggcagga     1380

gcaggacagt gacaagcttc ccacatcccc tttctggtaa gtgattctgg atcacagctg     1440

gaaaaacaca agatagttga ttcccaactt tcattcttaa aatggggaaa ctgagggcat     1500

gtgcgtgcac caacctgcca agcacagacc tgacacttca ggactttcct cacttaagtg     1560

tacggttttg gggaactggc tttcctttgt ccctgtagcc ccagtcactg cctctccagt     1620

cttctgtcat ctctcaggta taggttgtgc tgggcagctt tttcactgga agaccctcac     1680

cccaaagatc caccagttga gtcctaacag agcaatgcca ccctgaactg agggtcctct     1740

ggggctggag gcagggcttg agccaggcct ctgtcagggc agagaggtct ccggtcgagt     1800

ctgctctgac ctctcactct ccccttcttc ccagactgct gctcctgcta ccctgtgggc     1860

tgtgccaagt gtgcccaagg ctgcatttgc aaaggggcat cagataagtg cagctgctgt     1920

gcctgatgct gggacagccc tgctcacaga tgtagaaaga gtgacctata taaacttgga     1980

atttttttcc atgcaaccat gacccattta ctgtatttgt ctctc                     2025


<210> 21
<211> 49
<212> PRT
<213> Homo sapiens

<400> 21
Met Asp Leu Ser Cys Ser Cys Ala Thr Gly Gly Ser Cys Thr Cys Ala 
1               5                   10                  15      


Ser Ser Cys Lys Cys Lys Glu Tyr Lys Cys Thr Ser Cys Lys Lys Asn 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Met Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Thr 
    


<210> 22
<211> 376
<212> DNA
<213> Homo sapiens

<400> 22
cctgtggctt aggaactcca gcctcacctg atctccgaat ggacctcagc tgctcctgcg       60

ccactggtgg ctcctgcacc tgtgccagct cctgcaaatg caaagagtac aaatgcacct      120

cctgcaagaa gaactgctgc tcctgctgcc ccatgggctg tgccaaatgt gcccagggct      180

gcacctgaaa aggggcattg gagaagtgca gctgccgtgc ctgatgttgg gacagccctg      240

cgtccagttg taaataacgc aacccctaca aatctagttt ttttttaaac acaaacctaa      300

cccatttact atgtctgttt tcttaaatga aatatgggaa tgataataaa cattgttggc      360

cttaaaaaaa aaaaaa                                                      376


<210> 23
<211> 316
<212> DNA
<213> Homo sapiens

<400> 23
cctcttctct tctcgcttgg gaacgccggt ctcacctcgg cttgcaatgg accccaactg       60

ctcctgcgcc gctggaggct cctacgcctg cgccggctcc tgcaagtgca aaaagtgcaa      120

atgcacctcc tgcaagaaga gctgctgctc ctgttgcccc ctgggctgtg ccaagtgtgc      180

ccagggctgc atccgcaaag gggcttcgga aaagtgcagc tgctgtgcct gatgtcggga      240

ctgccctgct ctcggatgaa aacagaatga cacgtaaagt ccgggatttt tttttctaca      300

actccgactc atttgc                                                      316


<210> 24
<211> 599
<212> DNA
<213> Homo sapiens

<400> 24
gccctccatg tccaagggtt ccacatacac ggattcaaca aacctcagat caaaattatt       60

caaaaaatga aaataaaaaa taataatgca accatatgac accttccagt tgcctgactg      120

cctcttcacc tttcccatgg gaactccagc gtctcctttg ctcaaaacgg accccaacag      180

ctcctgcacc actggcggct gctggccctg tgctggctcc tgcaaatgca aagagtgcaa      240

atgcacctcc tgcaagaaga tctgctcctg ctgccctgtg ggctgtgcca agtgtgccca      300

gggctgcatc tgcaaagggg caacagagaa gtgcagctgc tgtgcctgat gtggggacag      360

ccctgctccc agatgtaaat gaagcaactt ggatacaaac ctggattttt tttttcatat      420

gaccctgagc catttgctac attccttttt ctataaatat gtaaataaca gtaaaacact      480

tttgacttaa aaaaaaatgc aacaatatga agtaatacaa ataaaaatac agtgttaaca      540

actatataca tagcatttac attgttctag gtattataag tcatctagag atgatttaa       599


<210> 25
<211> 377
<212> DNA
<213> Homo sapiens

<400> 25
ctcaggtcaa aaagtttggt aattggtgaa cacgccgtcc acgtgcgcct tgctgtctct       60

ccattatcgc ttgagatctc cagccttacc gcggcttgaa atggacccca actgctcctg      120

caccactggt ggctcctgca cgtgcgccgg ctcctgcaag tgcaaagagt gcaaatgcac      180

ctcctgcaag aagagctgct gctcctgctg ccccatgggc tgtgccaagt gtgcccaggg      240

ctgtgtctgc aaaggggcgt gcagctgctg tgtctgatgt ggggacagct cttctcccag      300

atgttaatag aacaacctgc acaacctggt tttttttcct taatacaacc ctgagccatt      360

tgctgcattt cttttca                                                     377


<210> 26
<211> 183
<212> DNA
<213> Homo sapiens

<400> 26
atggacccca actgctcctg ctcgcctgat ggttcctgcg cctgtgccgg ctcctgcaaa       60

tgaaaagagt gcacatgcac ctcctgcaag aagagctgct gctcctgctg ccctgtgggc      120

tgtgccaagt gtgcccaggg ctgcatctgc aaagggacgt cggacaactg cagctgctgt      180

gcc                                                                    183


<210> 27
<211> 60
<212> PRT
<213> Homo sapiens

<400> 27
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Asp Ser Cys Thr Cys Ala 
1               5                   10                  15      


Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys Ser 
            20                  25                  30          


Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly Cys 
        35                  40                  45              


Ile Cys Lys Gly Ala Ser Asp Lys Cys Ser Cys Cys 
    50                  55                  60  


<210> 28
<211> 466
<212> DNA
<213> Homo sapiens

<400> 28
cttgccgcgc tgcactccac cacgcctcct ccaagtccca gcgaacccgc gtgcaacctg       60

tcccgactct agccgcctct tcagctcgcc atggatccca actgctcctg cgccgccggt      120

gactcctgca cctgcgccgg ctcctgcaaa tgcaaagagt gcaaatgcac ctcctgcaag      180

aaaagctgct gctcctgctg ccctgtgggc tgtgccaagt gtgcccaggg ctgcatctgc      240

aaaggggcgt cggacaagtg cagctgctgc gcctgatgct gggacagccc cgctcccaga      300

tgtaaagaac gcgacttcca caaacctgga ttttttatgt acaaccctga ccgtgaccgt      360

ttgctatatt cctttttcta tgaaataatg tgaatgataa taaaacagct ttgacttgaa      420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                     466


<210> 29
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Lys Lys Ser Ser Cys Ser Cys Ser Pro Val Gly Ser Ala Lys 
1               5                   10                  


<210> 30
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Ala Gln Gly Ser Ile Ser Lys Gly Ala Ser Asp Lys Ser Ser 
1               5                   10                  


<210> 31
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Met Asp Pro Asn Ser Ser Ser Ala Ala Gly Asp Ser Ser Thr 
1               5                   10                  


<210> 32
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Ser Ala Gly Ser Ser Lys Ser Lys Glu Ser Lys Ser Thr Ser 
1               5                   10                  


<210> 33
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Ala Gln Gly Ser Ile Cys Lys Gly Ala Ser Asp Lys Ser Ser 
1               5                   10                  


<210> 34
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Asp Ser Ser Thr 
1               5                   10                  


<210> 35
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Ser Ala Gly Ser Cys Lys Cys Lys Glu Ser Lys Ser Thr Ser 
1               5                   10                  


<210> 36
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Lys Gly Gly Glu Ala Ala Glu Ala Glu Ala Glu Lys 
1               5                   10          


<210> 37
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Lys Lys Ser Cys Cys Ser Cys Cys Pro Met Ser Cys Ala Lys 
1               5                   10                  


<210> 38
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Lys Lys Cys Cys Gly Ser Cys Cys Pro Val Gly Cys Ala Lys 
1               5                   10                  


<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Lys Lys Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys 
1               5                   10                  


<210> 40
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Lys Lys Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ser Lys 
1               5                   10                  


<210> 41
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Lys Lys Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys 
1               5                   10                  


<210> 42
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Lys Lys Ser Cys Cys Ser Cys Cys Pro Leu Gly Cys Ala Lys 
1               5                   10                  


<210> 43
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Lys Lys Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys 
1               5                   10                  


<210> 44
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Lys Lys Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys 
1               5                   10                  


<210> 45
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Lys Lys Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys 
1               5                   10                  


<210> 46
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Lys Lys Ser Cys Cys Ser Cys Cys Pro Met Gly Cys Ala Lys 
1               5                   10                  


<210> 47
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Lys Lys Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys 
1               5                   10                  


<210> 48
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Lys Lys Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys 
1               5                   10                  


<210> 49
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Lys Lys Ser Cys Cys Ser Cys Cys Pro Ala Glu Cys Glu Lys 
1               5                   10                  


<210> 50
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Arg Lys Ser Cys Cys Pro Cys Cys Pro Pro Gly Cys Ala Lys 
1               5                   10                  


<210> 51
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Ala Gln Gly Cys Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser 
1               5                   10                  


<210> 52
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Ala Gln Gly Cys Val Cys Lys Gly Ser Ser Glu Lys Cys Ser 
1               5                   10                  


<210> 53
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Ala Gln Gly Cys Val Cys Lys Gly Ala Ser Glu Lys Cys Ser 
1               5                   10                  


<210> 54
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Ala Gln Gly Cys Val Cys Lys Gly Ala Ser Glu Lys Cys Ser 
1               5                   10                  


<210> 55
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Ala Gln Gly Cys Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser 
1               5                   10                  


<210> 56
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Ala Gln Gly Cys Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser 
1               5                   10                  


<210> 57
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Ala Gln Gly Cys Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser 
1               5                   10                  


<210> 58
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Ala Gln Gly Cys Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser 
1               5                   10                  


<210> 59
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Ala Gln Gly Cys Ile Cys Lys Gly Thr Ser Asp Lys Cys Ser 
1               5                   10                  


<210> 60
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Ala Gln Gly Cys Val Cys Lys Gly Ala Ser Glu Lys Cys Ser 
1               5                   10                  


<210> 61
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Ala Gln Gly Cys Ile Cys Lys Gly Thr Ser Asp Lys Cys Ser 
1               5                   10                  


<210> 62
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Ala Gln Gly Cys Ile Cys Lys Gly Ala Ser Asp Lys Cys Ser 
1               5                   10                  


<210> 63
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Ala Lys Asp Cys Val Cys Lys Gly Gly Glu Ala Ala Glu Ala Glu Ala 
1               5                   10                  15      


Glu Lys Cys Ser 
            20  


<210> 64
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Ala Arg Gly Cys Ile Cys Lys Gly Gly Ser Asp Lys Cys Ser 
1               5                   10                  


<210> 65
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Met Asp Pro Asn Cys Ser Cys Ala Thr Gly Gly Ser Cys Thr 
1               5                   10                  


<210> 66
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Met Asp Pro Asn Cys Ser Cys Thr Thr Gly Gly Ser Cys Ala 
1               5                   10                  


<210> 67
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Met Asp Pro Asn Cys Ser Cys Ala Thr Gly Gly Ser Cys Thr 
1               5                   10                  


<210> 68
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Val Ser Cys Thr 
1               5                   10                  


<210> 69
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Val Ser Cys Thr 
1               5                   10                  


<210> 70
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Met Asp Pro Asn Cys Ser Cys Glu Ala Gly Gly Ser Cys Ala 
1               5                   10                  


<210> 71
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Val Ser Cys Thr 
1               5                   10                  


<210> 72
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Met Asp Pro Asn Cys Ser Cys Ala Ala Ala Gly Val Ser Cys Thr 
1               5                   10                  15  


<210> 73
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Met Asp Pro Asn Cys Ser Cys Ser Pro Val Gly Ser Cys Ala 
1               5                   10                  


<210> 74
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Met Asp Pro Asn Cys Ser Cys Ala Thr Gly Gly Ser Cys Ser 
1               5                   10                  


<210> 75
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Met Asp Pro Asn Cys Ser Cys Asp Pro Val Gly Ser Cys Ala 
1               5                   10                  


<210> 76
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Met Asp Pro Asn Cys Ser Cys Ala Ala Gly Asp Ser Cys Thr 
1               5                   10                  


<210> 77
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 77
Met Asp Pro Glu Thr Cys Pro Cys Pro Ser Gly Gly Ser Cys Thr 
1               5                   10                  15  


<210> 78
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 78
Met Asp Pro Arg Glu Cys Val Cys Met Ser Gly Gly Ile Cys Met 
1               5                   10                  15  


<210> 79
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Cys Thr Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Asn Ser 
1               5                   10                  


<210> 80
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Cys Ala Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 81
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Cys Ala Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 82
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Cys Ala Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 83
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 83
Cys Ala Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 84
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 84
Cys Ala Gly Ser Cys Lys Cys Lys Lys Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 85
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 85
Cys Ala Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 86
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Cys Ala Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 87
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 87
Cys Ala Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 88
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 88
Cys Ala Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 89
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 89
Cys Ala Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 90
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Cys Ala Gly Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 91
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 91
Cys Ala Asp Ser Cys Lys Cys Glu Gly Cys Lys Cys Thr Ser 
1               5                   10                  


<210> 92
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 92
Cys Gly Asp Asn Cys Lys Cys Thr Thr Cys Asn Cys Lys Thr 
1               5                   10                  


