                         SEQUENCE LISTING

<110>  Bioblast Pharma Ltd.
 
<120>  Mitochondrial Proteins Constructs and Uses Thereof

<130>  2266197

<150>  US 61/811,934
<151>  2013-04-15

<150>  US 14/034,224
<151>  2013-09-23

<150>  US 61/869,981
<151>  2013-08-26

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  Human immunodeficiency virus type 1

<400>  1
aggaagaagc ggagacagcg acgaaga                                           27


<210>  2
<211>  237
<212>  DNA
<213>  Homo sapiens

<400>  2
tggactctcg ggcgccgcgc agtagccggc ctcctggcgt cacccagccc ggcccaggcc       60

cagaccctca cccgggtccc gcggccggca gagttggccc cactctgcgg ccgccgtggc      120

ctgcgcaccg acatcgatgc gacctgcacg ccccgccgcg caagttcgaa ccaacgtggc      180

ctcaaccaga tttggaatgt caaaaagcag agtgtctatt tgatgaattt gaggaaa         237


<210>  3
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  3
gctttactta ctgcggccgc ccggctcttg ggaaccaaga atgcatcttg tcttgttctt       60

gcagcccggc atgccagt                                                     78


<210>  4
<211>  102
<212>  DNA
<213>  Homo sapiens

<400>  4
ggagcactag tgattcgcgg tatcaggaat ttcaacctag agaaccgagc ggaacgggaa       60

atcagcaaga tgaagccctc tgtcgctccc agacacccct ct                         102


<210>  5
<211>  105
<212>  DNA
<213>  Homo sapiens

<400>  5
cagagctgga gtcgtgtgta ctgctccttg gccaagagag gccatttcaa tcgaatatct       60

catggcctac agggactttc tgcagtgcct ctgagaactt acgca                      105


<210>  6
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  6
tctggaactt tgggccaccc aggctctcta gatgagacca cctatgaaag actagcagag       60

gaaacgctgg actctttagc agagtttttt gaagaccttg cagacaagcc atacacgttt      120

gaggactatg atgtctcctt tgggagtggt gtcttaactg tcaaactggg tggagatcta      180

ggaacctatg tgatcaacaa gcagacgcca aacaagcaaa tctggctatc ttctccatcc      240

agtggaccta agcgttatga ctggactggg aaaaactggg tgtactccca cgacggcgtg      300

tccctccatg agctgctggc cgcagagctc actaaagcct taaaaaccaa actggacttg      360

tcttccttgg cctattccgg aaaagatgct tga                                   393


<210>  7
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for precursor frataxin cloning

<400>  7
cgcggatccg tggactctcg ggcgccg                                           27


<210>  8
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for precursor frataxin cloning

<400>  8
acgctcgagt caagcatctt ttccggaata ggc                                    33


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for MTS lad cloning

<400>  9
cgcggatcca cagagctgga gtcgtgtgta                                        30


<210>  10
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for MTS lad cloning

<400>  10
cataggtggt ctcatctaga gagcctgggt ggcccaaagt tccagatgcg taagttctca       60

gaggca                                                                  66


<210>  11
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for MTS orf cloning

<400>  11
cgcggatccg ggagcactag tgattcgc                                          28


<210>  12
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for MTS orf cloning

<400>  12
cataggtggt ctcatctaga gagcctgggt ggcccaaagt tccagaagag gggtgtctgg       60

gagcga                                                                  66


<210>  13
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward oligo for MTS cs cloning

<400>  13
gatccggctt tacttactgc ggccgcccgg ctcttgggaa ccaagaatgc atcttgtctt       60

gttcttgcag cccggcatgc cagttctgga actttgggcc acccaggctc tc              112


<210>  14
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for MTS cs cloning

<400>  14
tctagagagc ctgggtggcc caaagttcca gaactggcat gccgggctgc aagaacaaga       60

caagatgcat tcttggttcc caagagccgg gcggccgcag taagtaaagc cg              112


<210>  15
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  15
ctgaagggcc gtgaccttct cactctaaga aactttaccg gagaagaaat taaatatatg       60

ctatggctat cagcagatct gaaatttagg ataaaacaga aaggagagta tttgccttta      120

ttgcaaggga agtccttagg catgattttt gagaaaagaa gtactcgaac aagattgtct      180

acagaaacag gctttgcact tctgggagga catccttgtt ttcttaccac acaagatatt      240

catttgggtg tgaatgaaag tctcacggac acggcccgtg tattgtctag catggcagat      300

gcagtattgg ctcgagtgta taaacaatca gatttggaca ccctggctaa agaagcatcc      360

atcccaatta tcaatgggct gtcagatttg taccatccta tccagatcct ggctgattac      420

ctcacgctcc aggaacacta tagctctctg aaaggtctta ccctcagctg gatcggggat      480

gggaacaata tcctgcactc catcatgatg agcgcagcga aattcggaat gcaccttcag      540

gcagctactc caaagggtta tgagccggat gctagtgtaa ccaagttggc agagcagtat      600

gccaaagaga atggtaccaa gctgttgctg acaaatgatc cattggaagc agcgcatgga      660

ggcaatgtat taattacaga cacttggata agcatgggac aagaagagga gaagaaaaag      720

cggctccagg ctttccaagg ttaccaggtt acaatgaaga ctgctaaagt tgctgcctct      780

gactggacat ttttacactg cttgcccaga aagccagaag aagtggatga tgaagtcttt      840

tattctcctc gatcactagt gttcccagag gcagaaaaca gaaagtggac aatcatggct      900

gtcatggtgt ccctgctgac agattactca cctcagctcc agaagcctaa attttga         957


<210>  16
<211>  159
<212>  DNA
<213>  Homo sapiens

<400>  16
atgtaccgct acctggccaa agcgctgctg ccgtcccggg ccgggcccgc tgccctgggc       60

tccgcggcca accactcggc cgcgttgctg ggccggggcc gcggacagcc cgccgccgcc      120

tcgcagccgg ggctcgcatt ggccgcccgg cgccactac                             159


<210>  17
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His TAT MTS(cs) 81-210 FRA

<400>  17

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn 
        35                  40                  45              


Ala Ser Cys Leu Val Leu Ala Ala Arg His Ala Ser Ser Gly Thr Leu 
    50                  55                  60                  


Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu Ala Glu 
65                  70                  75                  80  


Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala Asp Lys 
                85                  90                  95      


Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly Val Leu 
            100                 105                 110         


Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn Lys Gln 
        115                 120                 125             


Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly Pro Lys 
    130                 135                 140                 


Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp Gly Val 
145                 150                 155                 160 


Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu Lys Thr 
                165                 170                 175     


Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
            180                 185                 190 


<210>  18
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTFrataxin [His TAT MTS(fra)81-210 FRA]

<400>  18

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser 
        35                  40                  45              


Pro Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala 
    50                  55                  60                  


Glu Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp 
65                  70                  75                  80  


Ala Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn 
                85                  90                  95      


Gln Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg 
            100                 105                 110         


Lys Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr 
        115                 120                 125             


Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu 
    130                 135                 140                 


Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe 
145                 150                 155                 160 


Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr 
                165                 170                 175     


Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro 
            180                 185                 190         


Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr 
        195                 200                 205             


Ser His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr 
    210                 215                 220                 


Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly 
225                 230                 235                 240 


Lys Asp Ala 
            


<210>  19
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His TAT MTS(lad) 81-210 FRA

<400>  19

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly 
        35                  40                  45              


His Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro 
    50                  55                  60                  


Leu Arg Thr Tyr Ala Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp 
65                  70                  75                  80  


Glu Thr Thr Tyr Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala 
                85                  90                  95      


Glu Phe Phe Glu Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr 
            100                 105                 110         


Asp Val Ser Phe Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp 
        115                 120                 125             


Leu Gly Thr Tyr Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp 
    130                 135                 140                 


Leu Ser Ser Pro Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys 
145                 150                 155                 160 


Asn Trp Val Tyr Ser His Asp Gly Val Ser Leu His Glu Leu Leu Ala 
                165                 170                 175     


Ala Glu Leu Thr Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu 
            180                 185                 190         


Ala Tyr Ser Gly Lys Asp Ala 
        195                 


<210>  20
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His TAT MTS(orf) 81-210 FRA

<400>  20

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Gly Ala Leu Val Ile Arg Gly Ile Arg Asn Phe Asn Leu Glu 
        35                  40                  45              


Asn Arg Ala Glu Arg Glu Ile Ser Lys Met Lys Pro Ser Val Ala Pro 
    50                  55                  60                  


Arg His Pro Ser Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu 
65                  70                  75                  80  


Thr Thr Tyr Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu 
                85                  90                  95      


Phe Phe Glu Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp 
            100                 105                 110         


Val Ser Phe Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu 
        115                 120                 125             


Gly Thr Tyr Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu 
    130                 135                 140                 


Ser Ser Pro Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn 
145                 150                 155                 160 


Trp Val Tyr Ser His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala 
                165                 170                 175     


Glu Leu Thr Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala 
            180                 185                 190         


Tyr Ser Gly Lys Asp Ala 
        195             


<210>  21
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  21

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  22
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  22

Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro Ser 
1               5                   10                  15      


Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu Leu 
            20                  25                  30          


Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala Thr 
        35                  40                  45              


Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile 
    50                  55                  60                  


Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  


<210>  23
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn Ala Ser 
1               5                   10                  15      


Cys Leu Val Leu Ala Ala Arg His Ala Ser 
            20                  25      


<210>  24
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His Phe 
1               5                   10                  15      


Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu Arg 
            20                  25                  30          


Thr Tyr Ala 
        35  


<210>  25
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Ala Leu Val Ile Arg Gly Ile Arg Asn Phe Asn Leu Glu Asn Arg 
1               5                   10                  15      


Ala Glu Arg Glu Ile Ser Lys Met Lys Pro Ser Val Ala Pro Arg His 
            20                  25                  30          


Pro Ser 
        


<210>  26
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
1               5                   10                  15      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            20                  25                  30          


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        35                  40                  45              


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    50                  55                  60                  


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
65                  70                  75                  80  


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                85                  90                  95      


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            100                 105                 110         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        115                 120                 125             


Asp Ala 
    130 


<210>  27
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus type 2

<400>  27

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  28
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT MTS(cs) 81-210 FRA

<400>  28

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser Asp Pro Ala Leu 
1               5                   10                  15      


Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn Ala Ser Cys Leu 
            20                  25                  30          


Val Leu Ala Ala Arg His Ala Ser Ser Gly Thr Leu Gly His Pro Gly 
        35                  40                  45              


Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu Ala Glu Glu Thr Leu Asp 
    50                  55                  60                  


Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala Asp Lys Pro Tyr Thr Phe 
65                  70                  75                  80  


Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly Val Leu Thr Val Lys Leu 
                85                  90                  95      


Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn Lys Gln Thr Pro Asn Lys 
            100                 105                 110         


Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly Pro Lys Arg Tyr Asp Trp 
        115                 120                 125             


Thr Gly Lys Asn Trp Val Tyr Ser His Asp Gly Val Ser Leu His Glu 
    130                 135                 140                 


Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu Lys Thr Lys Leu Asp Leu 
145                 150                 155                 160 


Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
                165                 170 


<210>  29
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT MTS(fra)81-210 FRA

<400>  29

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser Asp Pro Trp Thr 
1               5                   10                  15      


Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro Ser Pro Ala 
            20                  25                  30          


Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu Leu Ala Pro 
        35                  40                  45              


Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala Thr Cys Thr 
    50                  55                  60                  


Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile Trp Asn 
65                  70                  75                  80  


Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys Ser Gly Thr 
                85                  90                  95      


Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu Ala 
            100                 105                 110         


Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala Asp 
        115                 120                 125             


Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly Val 
    130                 135                 140                 


Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn Lys 
145                 150                 155                 160 


Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly Pro 
                165                 170                 175     


Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp Gly 
            180                 185                 190         


Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu Lys 
        195                 200                 205             


Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
    210                 215                 220             


<210>  30
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT MTS(lad) 81-210 FRA

<400>  30

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser Asp Pro Gln Ser 
1               5                   10                  15      


Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His Phe Asn Arg 
            20                  25                  30          


Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu Arg Thr Tyr 
        35                  40                  45              


Ala Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr 
    50                  55                  60                  


Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu 
65                  70                  75                  80  


Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe 
                85                  90                  95      


Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr 
            100                 105                 110         


Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro 
        115                 120                 125             


Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr 
    130                 135                 140                 


Ser His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr 
145                 150                 155                 160 


Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly 
                165                 170                 175     


Lys Asp Ala 
            


<210>  31
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT MTS(orf) 81-210 FRA

<400>  31

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser Asp Pro Gly Ala 
1               5                   10                  15      


Leu Val Ile Arg Gly Ile Arg Asn Phe Asn Leu Glu Asn Arg Ala Glu 
            20                  25                  30          


Arg Glu Ile Ser Lys Met Lys Pro Ser Val Ala Pro Arg His Pro Ser 
        35                  40                  45              


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
    50                  55                  60                  


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
65                  70                  75                  80  


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
                85                  90                  95      


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
            100                 105                 110         


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
        115                 120                 125             


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
    130                 135                 140                 


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
145                 150                 155                 160 


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
                165                 170                 175     


Asp Ala 
        


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  32

Gly Ser Asp Pro 
1               


<210>  33
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT MTS(cs) 81-210 FRA delta linker

<400>  33

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala Leu Leu Thr Ala Ala 
1               5                   10                  15      


Ala Arg Leu Leu Gly Thr Lys Asn Ala Ser Cys Leu Val Leu Ala Ala 
            20                  25                  30          


Arg His Ala Ser Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu 
        35                  40                  45              


Thr Thr Tyr Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu 
    50                  55                  60                  


Phe Phe Glu Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp 
65                  70                  75                  80  


Val Ser Phe Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu 
                85                  90                  95      


Gly Thr Tyr Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu 
            100                 105                 110         


Ser Ser Pro Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn 
        115                 120                 125             


Trp Val Tyr Ser His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala 
    130                 135                 140                 


Glu Leu Thr Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala 
145                 150                 155                 160 


Tyr Ser Gly Lys Asp Ala 
                165     


<210>  34
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT MTS(fra)81-210 FRA delta linker

<400>  34

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Trp Thr Leu Gly Arg Arg 
1               5                   10                  15      


Ala Val Ala Gly Leu Leu Ala Ser Pro Ser Pro Ala Gln Ala Gln Thr 
            20                  25                  30          


Leu Thr Arg Val Pro Arg Pro Ala Glu Leu Ala Pro Leu Cys Gly Arg 
        35                  40                  45              


Arg Gly Leu Arg Thr Asp Ile Asp Ala Thr Cys Thr Pro Arg Arg Ala 
    50                  55                  60                  


Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile Trp Asn Val Lys Lys Gln 
65                  70                  75                  80  


Ser Val Tyr Leu Met Asn Leu Arg Lys Ser Gly Thr Leu Gly His Pro 
                85                  90                  95      


Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu Ala Glu Glu Thr Leu 
            100                 105                 110         


Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala Asp Lys Pro Tyr Thr 
        115                 120                 125             


Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly Val Leu Thr Val Lys 
    130                 135                 140                 


Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn Lys Gln Thr Pro Asn 
145                 150                 155                 160 


Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly Pro Lys Arg Tyr Asp 
                165                 170                 175     


Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp Gly Val Ser Leu His 
            180                 185                 190         


Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu Lys Thr Lys Leu Asp 
        195                 200                 205             


Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
    210                 215                 


<210>  35
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT MTS(lad) 81-210 FRA delta linker

<400>  35

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gln Ser Trp Ser Arg Val 
1               5                   10                  15      


Tyr Cys Ser Leu Ala Lys Arg Gly His Phe Asn Arg Ile Ser His Gly 
            20                  25                  30          


Leu Gln Gly Leu Ser Ala Val Pro Leu Arg Thr Tyr Ala Ser Gly Thr 
        35                  40                  45              


Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu Ala 
    50                  55                  60                  


Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala Asp 
65                  70                  75                  80  


Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly Val 
                85                  90                  95      


Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn Lys 
            100                 105                 110         


Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly Pro 
        115                 120                 125             


Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp Gly 
    130                 135                 140                 


Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu Lys 
145                 150                 155                 160 


Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
                165                 170                 175 


<210>  36
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT MTS(orf) 81-210 FRA delta linker

<400>  36

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ala Leu Val Ile Arg 
1               5                   10                  15      


Gly Ile Arg Asn Phe Asn Leu Glu Asn Arg Ala Glu Arg Glu Ile Ser 
            20                  25                  30          


Lys Met Lys Pro Ser Val Ala Pro Arg His Pro Ser Ser Gly Thr Leu 
        35                  40                  45              


Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu Ala Glu 
    50                  55                  60                  


Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala Asp Lys 
65                  70                  75                  80  


Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly Val Leu 
                85                  90                  95      


Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn Lys Gln 
            100                 105                 110         


Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly Pro Lys 
        115                 120                 125             


Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp Gly Val 
    130                 135                 140                 


Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu Lys Thr 
145                 150                 155                 160 


Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
                165                 170                 


<210>  37
<211>  105
<212>  DNA
<213>  Homo sapiens

<400>  37
ctgtttaacc tgcgcattct gctgaacaat gcggccttcc gtaacggcca taattttatg       60

gtccgcaact tccgttgcgg tcagccgctg caaaataaag tgcag                      105


<210>  38
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  38

Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe Arg Asn Gly 
1               5                   10                  15      


His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Gln Asn 
            20                  25                  30          


Lys Val Gln 
        35  


<210>  39
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  39

Leu Lys Gly Arg Asp Leu Leu Thr Leu Arg Asn Phe Thr Gly Glu Glu 
1               5                   10                  15      


Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys Phe Arg Ile Lys 
            20                  25                  30          


Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys Ser Leu Gly Met 
        35                  40                  45              


Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser Thr Glu Thr Gly 
    50                  55                  60                  


Phe Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr Thr Gln Asp Ile 
65                  70                  75                  80  


His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala Arg Val Leu Ser 
                85                  90                  95      


Ser Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys Gln Ser Asp Leu 
            100                 105                 110         


Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile Asn Gly Leu Ser 
        115                 120                 125             


Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr Leu Thr Leu Gln 
    130                 135                 140                 


Glu His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser Trp Ile Gly Asp 
145                 150                 155                 160 


Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala Ala Lys Phe Gly 
                165                 170                 175     


Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu Pro Asp Ala Ser 
            180                 185                 190         


Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn Gly Thr Lys Leu 
        195                 200                 205             


Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly Gly Asn Val Leu 
    210                 215                 220                 


Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu Glu Lys Lys Lys 
225                 230                 235                 240 


Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met Lys Thr Ala Lys 
                245                 250                 255     


Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu Pro Arg Lys Pro 
            260                 265                 270         


Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg Ser Leu Val Phe 
        275                 280                 285             


Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala Val Met Val Ser 
    290                 295                 300                 


Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro Lys Phe 
305                 310                 315             


<210>  40
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-TAT-MTS(otc)-OTC delta inker

<400>  40
catatgggct catcgcatca tcatcatcat cactcatcag gtctggttcc gcgtggctcg       60

cacatgtatg gtcgcaaaaa acgtcgtcaa cgtcgccgtc tgtttaacct gcgcattctg      120

ctgaacaatg cggccttccg taacggccat aattttatgg tccgcaactt ccgttgcggt      180

cagccgctgc aaaataaagt gcagctgaaa ggccgcgatc tgctgaccct gcgtaacttc      240

acgggtgaag aaatcaaata catgctgtgg ctgagcgcag acctgaaatt ccgcatcaaa      300

caaaaaggcg aatacctgcc gctgctgcag ggcaaatctc tgggtatgat ttttgaaaaa      360

cgtagtaccc gcacgcgtct gtccaccgaa acgggctttg ccctgctggg cggtcatccg      420

tgtttcctga ccacgcaaga tatccacctg ggtgtgaacg aaagtctgac cgatacggca      480

cgcgttctga gctctatggc agacgctgtg ctggctcgtg tttataaaca gtccgatctg      540

gacaccctgg cgaaagaagc ctcaattccg attatcaatg gcctgtcgga tctgtaccat      600

ccgattcaaa tcctggcgga ctatctgacc ctgcaggaac actacagttc cctgaaaggt      660

ctgaccctga gttggatcgg cgatggtaac aatattctgc atagcatcat gatgtctgca      720

gctaaatttg gcatgcacct gcaagcggcc accccgaaag gttatgaacc ggatgccagc      780

gttacgaaac tggcagaaca gtacgctaaa gaaaacggta ccaaactgct gctgacgaat      840

gatccgctgg aagcagctca tggcggtaac gtcctgatta ccgacacgtg gatctctatg      900

ggccaggaag aagaaaagaa aaaacgtctg caggcgtttc aaggttatca ggttaccatg      960

aaaacggcca aagtcgcggc cagcgattgg accttcctgc actgcctgcc gcgtaaaccg     1020

gaagaagtcg atgacgaagt gttttactca ccgcgctcgc tggtgttccc ggaagcagaa     1080

aatcgtaaat ggaccatcat ggctgttatg gtgtccctgc tgaccgacta ttccccgcaa     1140

ctgcaaaaac cgaaattcta atgaaagctt                                      1170


<210>  41
<211>  1155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-TAT-MTS(cs)-OTC

<400>  41
catatgggct catctcatca tcatcatcat cattcgtcag gtctggtccc gcgtggctct       60

cacatgcgta aaaaacgtcg tcagcgtcgt cgtggcagtg atccggcact gctgaccgca      120

gcagcacgtc tgctgggtac gaaaaacgct agctgcctgg tgctggctgc gcgtcatgcg      180

tctgaatttc tgaaaggccg tgatctgctg accctgcgca acttcacggg tgaagaaatc      240

aaatacatgc tgtggctgag tgccgacctg aaatttcgta tcaaacaaaa aggcgaatac      300

ctgccgctgc tgcagggcaa atccctgggt atgattttcg aaaaacgcag tacccgtacg      360

cgcctgtcca ccgaaacggg ctttgcactg ctgggcggtc atccgtgttt cctgaccacg      420

caagatatcc acctgggtgt gaacgaatca ctgaccgata cggctcgtgt tctgagctct      480

atggcagacg cagtgctggc acgtgtttat aaacagtcgg atctggacac cctggctaaa      540

gaagcgtcaa ttccgattat caatggcctg tcggatctgt accatccgat tcaaatcctg      600

gcggactatc tgaccctgca ggaacactac agttccctga aaggtctgac cctgagctgg      660

atcggcgatg gtaacaatat tctgcatagc atcatgatgt ctgccgcaaa atttggcatg      720

cacctgcaag ctgcgacccc gaaaggttat gaaccggacg ccagcgtcac gaaactggcc      780

gaacagtacg caaaagaaaa cggtaccaaa ctgctgctga cgaatgatcc gctggaagcc      840

gcacatggcg gtaacgttct gattaccgac acgtggatca gcatgggcca ggaagaagaa      900

aagaaaaaac gtctgcaggc ctttcaaggt tatcaggtta ccatgaaaac ggcaaaagtc      960

gctgcgtctg attggacctt cctgcactgc ctgccgcgca aaccggaaga agtcgatgac     1020

gaagtgtttt actcaccgcg ttcgctggtt ttcccggaag cggaaaatcg caaatggacc     1080

attatggctg tgatggtctc tctgctgacg gactactcgc cgcaactgca aaaaccgaaa     1140

ttctaatgaa agctt                                                      1155


<210>  42
<211>  1179
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-TAT-MTS(orf)-OTC

<400>  42
catatgggtt catcacatca tcatcatcat cattcatcag gtctggtccc gcgtggttca       60

cacatgcgta aaaaacgtcg tcagcgtcgt cgtggcagtg atccgggtgc gctggtcatt      120

cgtggcatcc gcaactttaa tctggaaaac cgtgcggaac gcgaaattag taaaatgaaa      180

ccgtccgtgg caccgcgtca tccgtctgaa tttctgaaag gccgtgatct gctgaccctg      240

cgcaacttca cgggtgaaga aatcaaatac atgctgtggc tgagtgcaga cctgaaattc      300

cgtatcaaac aaaagggtga atacctgccg ctgctgcagg gcaaatccct gggtatgatt      360

ttcgaaaaac gctcaacccg tacgcgcctg tcgaccgaaa cgggctttgc cctgctgggc      420

ggtcatccgt gcttcctgac cacgcaagat atccacctgg gtgtgaacga atcactgacc      480

gatacggcac gtgttctgag ctctatggca gacgcagtgc tggctcgtgt ttataaacag      540

tcggatctgg acaccctggc aaaagaagct agcattccga ttatcaatgg cctgtctgat      600

ctgtaccatc cgattcaaat cctggcggac tatctgaccc tgcaggaaca ctacagttcc      660

ctgaaaggtc tgaccctgag ctggatcggc gatggtaaca atattctgca tagcatcatg      720

atgtctgcgg ccaaattcgg catgcacctg caagcagcta ccccgaaagg ttatgaaccg      780

gacgcctccg ttacgaaact ggcggaacag tacgccaaag aaaacggcac caaactgctg      840

ctgacgaatg atccgctgga agcggcccat ggcggtaacg tcctgattac cgacacgtgg      900

atcagcatgg gccaggaaga agaaaagaaa aaacgtctgc aggcatttca aggttatcag      960

gttaccatga aaacggctaa agtcgcagct tctgattgga ccttcctgca ctgtctgccg     1020

cgcaaaccgg aagaagtcga tgacgaagtg ttttactcac cgcgttcgct ggtgttcccg     1080

gaagcggaaa atcgcaaatg gaccattatg gctgtgatgg tgtcgctgct gacggactac     1140

tcgccgcaac tgcaaaaacc gaaattctaa tgaaagctt                            1179


<210>  43
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-TAT-MTS(lad)-OTC

<400>  43
catatgggta gttcacatca tcatcatcat cactcgtcgg gtctggtgcc gcgtggctca       60

cacatgcgta aaaaacgtcg tcagcgtcgt cgtggctcag atccgcaatc atggtcgcgc      120

gtctattgct cgctggcgaa acgtggtcat tttaaccgca ttagccacgg cctgcagggt      180

ctgtctgcag tgccgctgcg tacctacgct gaatttctga aaggccgtga tctgctgacc      240

ctgcgcaact tcacgggtga agaaatcaaa tacatgctgt ggctgagcgc agacctgaaa      300

tttcgtatca aacaaaaagg cgaatacctg ccgctgctgc agggcaaatc tctgggtatg      360

attttcgaaa aacgctcaac ccgtacgcgc ctgtcgaccg aaacgggctt tgccctgctg      420

ggcggtcatc cgtgtttcct gaccacgcag gatatccacc tgggtgtgaa cgaaagtctg      480

accgatacgg cacgtgttct gagctctatg gcagacgcag tgctggctcg tgtttataaa      540

cagtccgatc tggacaccct ggcaaaagaa gctagtattc cgattatcaa tggcctgtcc      600

gatctgtacc atccgattca aatcctggcg gactatctga ccctgcagga acactacagt      660

tccctgaaag gtctgacgct gagctggatc ggcgatggta acaatattct gcatagtatc      720

atgatgtccg cggccaaatt cggcatgcac ctgcaagcag ctaccccgaa aggttatgaa      780

ccggacgcct ctgttacgaa actggcggaa cagtacgcca aagaaaacgg taccaaactg      840

ctgctgacga atgatccgct ggaagcggcc catggcggta acgtcctgat taccgacacg      900

tggatcagta tgggccagga agaagaaaag aaaaaacgtc tgcaggcgtt tcaaggttat      960

caggttacca tgaaaacggc caaagtcgca gctagcgatt ggaccttcct gcactgcctg     1020

ccgcgcaaac cggaagaagt cgatgacgaa gtgttttata gcccgcgttc tctggtgttc     1080

ccggaagcgg aaaatcgcaa atggaccatc atggccgtta tggtgtcgct gctgaccgat     1140

tactccccgc aactgcaaaa accgaaattc taatgaaagc tt                        1182


<210>  44
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-TAT-MTS(otc)-OTC delta linker

<400>  44

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
            20                  25                  30          


Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe Arg Asn Gly 
        35                  40                  45              


His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Gln Asn 
    50                  55                  60                  


Lys Val Gln Leu Lys Gly Arg Asp Leu Leu Thr Leu Arg Asn Phe Thr 
65                  70                  75                  80  


Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys Phe 
                85                  90                  95      


Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys Ser 
            100                 105                 110         


Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser Thr 
        115                 120                 125             


Glu Thr Gly Phe Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr Thr 
    130                 135                 140                 


Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala Arg 
145                 150                 155                 160 


Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys Gln 
                165                 170                 175     


Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile Asn 
            180                 185                 190         


Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr Leu 
        195                 200                 205             


Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser Trp 
    210                 215                 220                 


Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala Ala 
225                 230                 235                 240 


Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu Pro 
                245                 250                 255     


Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn Gly 
            260                 265                 270         


Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly Gly 
        275                 280                 285             


Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu Glu 
    290                 295                 300                 


Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met Lys 
305                 310                 315                 320 


Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu Pro 
                325                 330                 335     


Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg Ser 
            340                 345                 350         


Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala Val 
        355                 360                 365             


Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro Lys 
    370                 375                 380                 


Phe 
385 


<210>  45
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-TAT-MTS(cs)-OTC

<400>  45

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn 
        35                  40                  45              


Ala Ser Cys Leu Val Leu Ala Ala Arg His Ala Ser Glu Phe Leu Lys 
    50                  55                  60                  


Gly Arg Asp Leu Leu Thr Leu Arg Asn Phe Thr Gly Glu Glu Ile Lys 
65                  70                  75                  80  


Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys Phe Arg Ile Lys Gln Lys 
                85                  90                  95      


Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys Ser Leu Gly Met Ile Phe 
            100                 105                 110         


Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser Thr Glu Thr Gly Phe Ala 
        115                 120                 125             


Leu Leu Gly Gly His Pro Cys Phe Leu Thr Thr Gln Asp Ile His Leu 
    130                 135                 140                 


Gly Val Asn Glu Ser Leu Thr Asp Thr Ala Arg Val Leu Ser Ser Met 
145                 150                 155                 160 


Ala Asp Ala Val Leu Ala Arg Val Tyr Lys Gln Ser Asp Leu Asp Thr 
                165                 170                 175     


Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile Asn Gly Leu Ser Asp Leu 
            180                 185                 190         


Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr Leu Thr Leu Gln Glu His 
        195                 200                 205             


Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser Trp Ile Gly Asp Gly Asn 
    210                 215                 220                 


Asn Ile Leu His Ser Ile Met Met Ser Ala Ala Lys Phe Gly Met His 
225                 230                 235                 240 


Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu Pro Asp Ala Ser Val Thr 
                245                 250                 255     


Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn Gly Thr Lys Leu Leu Leu 
            260                 265                 270         


Thr Asn Asp Pro Leu Glu Ala Ala His Gly Gly Asn Val Leu Ile Thr 
        275                 280                 285             


Asp Thr Trp Ile Ser Met Gly Gln Glu Glu Glu Lys Lys Lys Arg Leu 
    290                 295                 300                 


Gln Ala Phe Gln Gly Tyr Gln Val Thr Met Lys Thr Ala Lys Val Ala 
305                 310                 315                 320 


Ala Ser Asp Trp Thr Phe Leu His Cys Leu Pro Arg Lys Pro Glu Glu 
                325                 330                 335     


Val Asp Asp Glu Val Phe Tyr Ser Pro Arg Ser Leu Val Phe Pro Glu 
            340                 345                 350         


Ala Glu Asn Arg Lys Trp Thr Ile Met Ala Val Met Val Ser Leu Leu 
        355                 360                 365             


Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro Lys Phe 
    370                 375                 380 


<210>  46
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-TAT-MTS(orf)-OTC

<400>  46

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Gly Ala Leu Val Ile Arg Gly Ile Arg Asn Phe Asn Leu Glu 
        35                  40                  45              


Asn Arg Ala Glu Arg Glu Ile Ser Lys Met Lys Pro Ser Val Ala Pro 
    50                  55                  60                  


Arg His Pro Ser Glu Phe Leu Lys Gly Arg Asp Leu Leu Thr Leu Arg 
65                  70                  75                  80  


Asn Phe Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp 
                85                  90                  95      


Leu Lys Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln 
            100                 105                 110         


Gly Lys Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg 
        115                 120                 125             


Leu Ser Thr Glu Thr Gly Phe Ala Leu Leu Gly Gly His Pro Cys Phe 
    130                 135                 140                 


Leu Thr Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp 
145                 150                 155                 160 


Thr Ala Arg Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val 
                165                 170                 175     


Tyr Lys Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro 
            180                 185                 190         


Ile Ile Asn Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala 
        195                 200                 205             


Asp Tyr Leu Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr 
    210                 215                 220                 


Leu Ser Trp Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met 
225                 230                 235                 240 


Ser Ala Ala Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly 
                245                 250                 255     


Tyr Glu Pro Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys 
            260                 265                 270         


Glu Asn Gly Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala 
        275                 280                 285             


His Gly Gly Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln 
    290                 295                 300                 


Glu Glu Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val 
305                 310                 315                 320 


Thr Met Lys Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His 
                325                 330                 335     


Cys Leu Pro Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser 
            340                 345                 350         


Pro Arg Ser Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile 
        355                 360                 365             


Met Ala Val Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln 
    370                 375                 380                 


Lys Pro Lys Phe 
385             


<210>  47
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-TAT-MTS(lad)-OTC

<400>  47

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly 
        35                  40                  45              


His Phe Asn Arg Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro 
    50                  55                  60                  


Leu Arg Thr Tyr Ala Glu Phe Leu Lys Gly Arg Asp Leu Leu Thr Leu 
65                  70                  75                  80  


Arg Asn Phe Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala 
                85                  90                  95      


Asp Leu Lys Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu 
            100                 105                 110         


Gln Gly Lys Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr 
        115                 120                 125             


Arg Leu Ser Thr Glu Thr Gly Phe Ala Leu Leu Gly Gly His Pro Cys 
    130                 135                 140                 


Phe Leu Thr Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr 
145                 150                 155                 160 


Asp Thr Ala Arg Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg 
                165                 170                 175     


Val Tyr Lys Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile 
            180                 185                 190         


Pro Ile Ile Asn Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu 
        195                 200                 205             


Ala Asp Tyr Leu Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu 
    210                 215                 220                 


Thr Leu Ser Trp Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met 
225                 230                 235                 240 


Met Ser Ala Ala Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys 
                245                 250                 255     


Gly Tyr Glu Pro Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala 
            260                 265                 270         


Lys Glu Asn Gly Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala 
        275                 280                 285             


Ala His Gly Gly Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly 
    290                 295                 300                 


Gln Glu Glu Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln 
305                 310                 315                 320 


Val Thr Met Lys Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu 
                325                 330                 335     


His Cys Leu Pro Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr 
            340                 345                 350         


Ser Pro Arg Ser Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr 
        355                 360                 365             


Ile Met Ala Val Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu 
    370                 375                 380                 


Gln Lys Pro Lys Phe 
385                 


<210>  48
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT-MTS(otc)-OTC delta linker

<400>  48

Arg Lys Lys Arg Arg Gln Arg Arg Arg Leu Phe Asn Leu Arg Ile Leu 
1               5                   10                  15      


Leu Asn Asn Ala Ala Phe Arg Asn Gly His Asn Phe Met Val Arg Asn 
            20                  25                  30          


Phe Arg Cys Gly Gln Pro Leu Gln Asn Lys Val Gln Leu Lys Gly Arg 
        35                  40                  45              


Asp Leu Leu Thr Leu Arg Asn Phe Thr Gly Glu Glu Ile Lys Tyr Met 
    50                  55                  60                  


Leu Trp Leu Ser Ala Asp Leu Lys Phe Arg Ile Lys Gln Lys Gly Glu 
65                  70                  75                  80  


Tyr Leu Pro Leu Leu Gln Gly Lys Ser Leu Gly Met Ile Phe Glu Lys 
                85                  90                  95      


Arg Ser Thr Arg Thr Arg Leu Ser Thr Glu Thr Gly Phe Ala Leu Leu 
            100                 105                 110         


Gly Gly His Pro Cys Phe Leu Thr Thr Gln Asp Ile His Leu Gly Val 
        115                 120                 125             


Asn Glu Ser Leu Thr Asp Thr Ala Arg Val Leu Ser Ser Met Ala Asp 
    130                 135                 140                 


Ala Val Leu Ala Arg Val Tyr Lys Gln Ser Asp Leu Asp Thr Leu Ala 
145                 150                 155                 160 


Lys Glu Ala Ser Ile Pro Ile Ile Asn Gly Leu Ser Asp Leu Tyr His 
                165                 170                 175     


Pro Ile Gln Ile Leu Ala Asp Tyr Leu Thr Leu Gln Glu His Tyr Ser 
            180                 185                 190         


Ser Leu Lys Gly Leu Thr Leu Ser Trp Ile Gly Asp Gly Asn Asn Ile 
        195                 200                 205             


Leu His Ser Ile Met Met Ser Ala Ala Lys Phe Gly Met His Leu Gln 
    210                 215                 220                 


Ala Ala Thr Pro Lys Gly Tyr Glu Pro Asp Ala Ser Val Thr Lys Leu 
225                 230                 235                 240 


Ala Glu Gln Tyr Ala Lys Glu Asn Gly Thr Lys Leu Leu Leu Thr Asn 
                245                 250                 255     


Asp Pro Leu Glu Ala Ala His Gly Gly Asn Val Leu Ile Thr Asp Thr 
            260                 265                 270         


Trp Ile Ser Met Gly Gln Glu Glu Glu Lys Lys Lys Arg Leu Gln Ala 
        275                 280                 285             


Phe Gln Gly Tyr Gln Val Thr Met Lys Thr Ala Lys Val Ala Ala Ser 
    290                 295                 300                 


Asp Trp Thr Phe Leu His Cys Leu Pro Arg Lys Pro Glu Glu Val Asp 
305                 310                 315                 320 


Asp Glu Val Phe Tyr Ser Pro Arg Ser Leu Val Phe Pro Glu Ala Glu 
                325                 330                 335     


Asn Arg Lys Trp Thr Ile Met Ala Val Met Val Ser Leu Leu Thr Asp 
            340                 345                 350         


Tyr Ser Pro Gln Leu Gln Lys Pro Lys Phe 
        355                 360         


<210>  49
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT-MTS(cs)-OTC

<400>  49

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser Asp Pro Ala Leu 
1               5                   10                  15      


Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn Ala Ser Cys Leu 
            20                  25                  30          


Val Leu Ala Ala Arg His Ala Ser Glu Phe Leu Lys Gly Arg Asp Leu 
        35                  40                  45              


Leu Thr Leu Arg Asn Phe Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp 
    50                  55                  60                  


Leu Ser Ala Asp Leu Lys Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu 
65                  70                  75                  80  


Pro Leu Leu Gln Gly Lys Ser Leu Gly Met Ile Phe Glu Lys Arg Ser 
                85                  90                  95      


Thr Arg Thr Arg Leu Ser Thr Glu Thr Gly Phe Ala Leu Leu Gly Gly 
            100                 105                 110         


His Pro Cys Phe Leu Thr Thr Gln Asp Ile His Leu Gly Val Asn Glu 
        115                 120                 125             


Ser Leu Thr Asp Thr Ala Arg Val Leu Ser Ser Met Ala Asp Ala Val 
    130                 135                 140                 


Leu Ala Arg Val Tyr Lys Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu 
145                 150                 155                 160 


Ala Ser Ile Pro Ile Ile Asn Gly Leu Ser Asp Leu Tyr His Pro Ile 
                165                 170                 175     


Gln Ile Leu Ala Asp Tyr Leu Thr Leu Gln Glu His Tyr Ser Ser Leu 
            180                 185                 190         


Lys Gly Leu Thr Leu Ser Trp Ile Gly Asp Gly Asn Asn Ile Leu His 
        195                 200                 205             


Ser Ile Met Met Ser Ala Ala Lys Phe Gly Met His Leu Gln Ala Ala 
    210                 215                 220                 


Thr Pro Lys Gly Tyr Glu Pro Asp Ala Ser Val Thr Lys Leu Ala Glu 
225                 230                 235                 240 


Gln Tyr Ala Lys Glu Asn Gly Thr Lys Leu Leu Leu Thr Asn Asp Pro 
                245                 250                 255     


Leu Glu Ala Ala His Gly Gly Asn Val Leu Ile Thr Asp Thr Trp Ile 
            260                 265                 270         


Ser Met Gly Gln Glu Glu Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln 
        275                 280                 285             


Gly Tyr Gln Val Thr Met Lys Thr Ala Lys Val Ala Ala Ser Asp Trp 
    290                 295                 300                 


Thr Phe Leu His Cys Leu Pro Arg Lys Pro Glu Glu Val Asp Asp Glu 
305                 310                 315                 320 


Val Phe Tyr Ser Pro Arg Ser Leu Val Phe Pro Glu Ala Glu Asn Arg 
                325                 330                 335     


Lys Trp Thr Ile Met Ala Val Met Val Ser Leu Leu Thr Asp Tyr Ser 
            340                 345                 350         


Pro Gln Leu Gln Lys Pro Lys Phe 
        355                 360 


<210>  50
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT-MTS(orf)-OTC

<400>  50

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser Asp Pro Gly Ala 
1               5                   10                  15      


Leu Val Ile Arg Gly Ile Arg Asn Phe Asn Leu Glu Asn Arg Ala Glu 
            20                  25                  30          


Arg Glu Ile Ser Lys Met Lys Pro Ser Val Ala Pro Arg His Pro Ser 
        35                  40                  45              


Glu Phe Leu Lys Gly Arg Asp Leu Leu Thr Leu Arg Asn Phe Thr Gly 
    50                  55                  60                  


Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys Phe Arg 
65                  70                  75                  80  


Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys Ser Leu 
                85                  90                  95      


Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser Thr Glu 
            100                 105                 110         


Thr Gly Phe Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr Thr Gln 
        115                 120                 125             


Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala Arg Val 
    130                 135                 140                 


Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys Gln Ser 
145                 150                 155                 160 


Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile Asn Gly 
                165                 170                 175     


Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr Leu Thr 
            180                 185                 190         


Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser Trp Ile 
        195                 200                 205             


Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala Ala Lys 
    210                 215                 220                 


Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu Pro Asp 
225                 230                 235                 240 


Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn Gly Thr 
                245                 250                 255     


Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly Gly Asn 
            260                 265                 270         


Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu Glu Lys 
        275                 280                 285             


Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met Lys Thr 
    290                 295                 300                 


Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu Pro Arg 
305                 310                 315                 320 


Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg Ser Leu 
                325                 330                 335     


Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala Val Met 
            340                 345                 350         


Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro Lys Phe 
        355                 360                 365             


<210>  51
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT-MTS(lad)-OTC

<400>  51

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ser Asp Pro Gln Ser 
1               5                   10                  15      


Trp Ser Arg Val Tyr Cys Ser Leu Ala Lys Arg Gly His Phe Asn Arg 
            20                  25                  30          


Ile Ser His Gly Leu Gln Gly Leu Ser Ala Val Pro Leu Arg Thr Tyr 
        35                  40                  45              


Ala Glu Phe Leu Lys Gly Arg Asp Leu Leu Thr Leu Arg Asn Phe Thr 
    50                  55                  60                  


Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys Phe 
65                  70                  75                  80  


Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys Ser 
                85                  90                  95      


Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser Thr 
            100                 105                 110         


Glu Thr Gly Phe Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr Thr 
        115                 120                 125             


Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala Arg 
    130                 135                 140                 


Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys Gln 
145                 150                 155                 160 


Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile Asn 
                165                 170                 175     


Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr Leu 
            180                 185                 190         


Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser Trp 
        195                 200                 205             


Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala Ala 
    210                 215                 220                 


Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu Pro 
225                 230                 235                 240 


Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn Gly 
                245                 250                 255     


Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly Gly 
            260                 265                 270         


Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu Glu 
        275                 280                 285             


Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met Lys 
    290                 295                 300                 


Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu Pro 
305                 310                 315                 320 


Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg Ser 
                325                 330                 335     


Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala Val 
            340                 345                 350         


Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro Lys 
        355                 360                 365             


Phe 
    


<210>  52
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT-MTS(cs)-OTC delta linker

<400>  52

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala Leu Leu Thr Ala Ala 
1               5                   10                  15      


Ala Arg Leu Leu Gly Thr Lys Asn Ala Ser Cys Leu Val Leu Ala Ala 
            20                  25                  30          


Arg His Ala Ser Glu Phe Leu Lys Gly Arg Asp Leu Leu Thr Leu Arg 
        35                  40                  45              


Asn Phe Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp 
    50                  55                  60                  


Leu Lys Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln 
65                  70                  75                  80  


Gly Lys Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg 
                85                  90                  95      


Leu Ser Thr Glu Thr Gly Phe Ala Leu Leu Gly Gly His Pro Cys Phe 
            100                 105                 110         


Leu Thr Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp 
        115                 120                 125             


Thr Ala Arg Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val 
    130                 135                 140                 


Tyr Lys Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro 
145                 150                 155                 160 


Ile Ile Asn Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala 
                165                 170                 175     


Asp Tyr Leu Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr 
            180                 185                 190         


Leu Ser Trp Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met 
        195                 200                 205             


Ser Ala Ala Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly 
    210                 215                 220                 


Tyr Glu Pro Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys 
225                 230                 235                 240 


Glu Asn Gly Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala 
                245                 250                 255     


His Gly Gly Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln 
            260                 265                 270         


Glu Glu Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val 
        275                 280                 285             


Thr Met Lys Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His 
    290                 295                 300                 


Cys Leu Pro Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser 
305                 310                 315                 320 


Pro Arg Ser Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile 
                325                 330                 335     


Met Ala Val Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln 
            340                 345                 350         


Lys Pro Lys Phe 
        355     


<210>  53
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT-MTS(orf)-OTC delta linker

<400>  53

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Ala Leu Val Ile Arg 
1               5                   10                  15      


Gly Ile Arg Asn Phe Asn Leu Glu Asn Arg Ala Glu Arg Glu Ile Ser 
            20                  25                  30          


Lys Met Lys Pro Ser Val Ala Pro Arg His Pro Ser Glu Phe Leu Lys 
        35                  40                  45              


Gly Arg Asp Leu Leu Thr Leu Arg Asn Phe Thr Gly Glu Glu Ile Lys 
    50                  55                  60                  


Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys Phe Arg Ile Lys Gln Lys 
65                  70                  75                  80  


Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys Ser Leu Gly Met Ile Phe 
                85                  90                  95      


Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser Thr Glu Thr Gly Phe Ala 
            100                 105                 110         


Leu Leu Gly Gly His Pro Cys Phe Leu Thr Thr Gln Asp Ile His Leu 
        115                 120                 125             


Gly Val Asn Glu Ser Leu Thr Asp Thr Ala Arg Val Leu Ser Ser Met 
    130                 135                 140                 


Ala Asp Ala Val Leu Ala Arg Val Tyr Lys Gln Ser Asp Leu Asp Thr 
145                 150                 155                 160 


Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile Asn Gly Leu Ser Asp Leu 
                165                 170                 175     


Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr Leu Thr Leu Gln Glu His 
            180                 185                 190         


Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser Trp Ile Gly Asp Gly Asn 
        195                 200                 205             


Asn Ile Leu His Ser Ile Met Met Ser Ala Ala Lys Phe Gly Met His 
    210                 215                 220                 


Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu Pro Asp Ala Ser Val Thr 
225                 230                 235                 240 


Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn Gly Thr Lys Leu Leu Leu 
                245                 250                 255     


Thr Asn Asp Pro Leu Glu Ala Ala His Gly Gly Asn Val Leu Ile Thr 
            260                 265                 270         


Asp Thr Trp Ile Ser Met Gly Gln Glu Glu Glu Lys Lys Lys Arg Leu 
        275                 280                 285             


Gln Ala Phe Gln Gly Tyr Gln Val Thr Met Lys Thr Ala Lys Val Ala 
    290                 295                 300                 


Ala Ser Asp Trp Thr Phe Leu His Cys Leu Pro Arg Lys Pro Glu Glu 
305                 310                 315                 320 


Val Asp Asp Glu Val Phe Tyr Ser Pro Arg Ser Leu Val Phe Pro Glu 
                325                 330                 335     


Ala Glu Asn Arg Lys Trp Thr Ile Met Ala Val Met Val Ser Leu Leu 
            340                 345                 350         


Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro Lys Phe 
        355                 360                 


<210>  54
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT-MTS(lad)-OTC delta linker

<400>  54

Met Arg Lys Lys Arg Arg Gln Arg Arg Arg Gln Ser Trp Ser Arg Val 
1               5                   10                  15      


Tyr Cys Ser Leu Ala Lys Arg Gly His Phe Asn Arg Ile Ser His Gly 
            20                  25                  30          


Leu Gln Gly Leu Ser Ala Val Pro Leu Arg Thr Tyr Ala Glu Phe Leu 
        35                  40                  45              


Lys Gly Arg Asp Leu Leu Thr Leu Arg Asn Phe Thr Gly Glu Glu Ile 
    50                  55                  60                  


Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys Phe Arg Ile Lys Gln 
65                  70                  75                  80  


Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys Ser Leu Gly Met Ile 
                85                  90                  95      


Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser Thr Glu Thr Gly Phe 
            100                 105                 110         


Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr Thr Gln Asp Ile His 
        115                 120                 125             


Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala Arg Val Leu Ser Ser 
    130                 135                 140                 


Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys Gln Ser Asp Leu Asp 
145                 150                 155                 160 


Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile Asn Gly Leu Ser Asp 
                165                 170                 175     


Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr Leu Thr Leu Gln Glu 
            180                 185                 190         


His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser Trp Ile Gly Asp Gly 
        195                 200                 205             


Asn Asn Ile Leu His Ser Ile Met Met Ser Ala Ala Lys Phe Gly Met 
    210                 215                 220                 


His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu Pro Asp Ala Ser Val 
225                 230                 235                 240 


Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn Gly Thr Lys Leu Leu 
                245                 250                 255     


Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly Gly Asn Val Leu Ile 
            260                 265                 270         


Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu Glu Lys Lys Lys Arg 
        275                 280                 285             


Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met Lys Thr Ala Lys Val 
    290                 295                 300                 


Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu Pro Arg Lys Pro Glu 
305                 310                 315                 320 


Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg Ser Leu Val Phe Pro 
                325                 330                 335     


Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala Val Met Val Ser Leu 
            340                 345                 350         


Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro Lys Phe 
        355                 360                 365 


