                         SEQUENCE LISTING

<110>  Pfizer Limited
       Storer, Robert I
       Owen, Robert M
 
<120>  Chemical Compounds

<130>  PC72012

<150>  US61/813796
<151>  2013-04-19

<150>  US61/930025
<151>  2014-01-22

<160>  3     

<170>  PatentIn version 3.3

<210>  1
<211>  1692
<212>  DNA
<213>  Homo sapiens

<400>  1
gggcccctct tctgggcccc ttgagtaggt tccatggcat tttctgaact cctggacctc     60

gtgggtggcc tgggcaggtt ccaggttctc cagacgatgg ctctgatggt ctccatcatg    120

tggctgtgta cccagagcat gctggagaac ttctcggccg ccgtgcccag ccaccgctgc    180

tgggcacccc tcctggacaa cagcacggct caggccagca tcctagggag cttgagtcct    240

gaggccctcc tggctatttc catcccgccg ggccccaacc agaggcccca ccagtgccgc    300

cgcttccgcc agccacagtg gcagctcttg gaccccaatg ccacggccac cagctggagc    360

gaggccgaca cggagccgtg tgtggatggc tgggtctatg accgcagcat cttcacctcc    420

acaatcgtgg ccaagtggaa cctcgtgtgt gactctcatg ctctgaagcc catggcccag    480

tccatctacc tggctgggat tctggtggga gctgctgcgt gcggccctgc ctcagacagg    540

tttgggcgca ggctggtgct aacctggagc taccttcaga tggctgtgat gggtacggca    600

gctgccttcg cccctgcctt ccccgtgtac tgcctgttcc gcttcctgtt ggcctttgcc    660

gtggcaggcg tcatgatgaa cacgggcact ctcctgatgg agtggacggc ggcacgggcc    720

cgacccttgg tgatgacctt gaactctctg ggcttcagct tcggccatgg cctgacagct    780

gcagtggcct acggtgtgcg ggactggaca ctgctgcagc tggtggtctc ggtccccttc    840

ttcctctgct ttttgtactc ctggtggctg gcagagtcgg cacgatggct cctcaccaca    900

ggcaggctgg attggggcct gcaggagctg tggagggtgg ctgccatcaa cggaaagggg    960

gcagtgcagg acaccctgac ccctgaggtc ttgctttcag ccatgcggga ggagctgagc   1020

atgggccagc ctcctgccag cctgggcacc ctgctccgca tgcccggact gcgcttccgg   1080

acctgtatct ccacgttgtg ctggttcgcc tttggcttca ccttcttcgg cctggccctg   1140

gacctgcagg ccctgggcag caacatcttc ctgctccaaa tgttcattgg tgtcgtggac   1200

atcccagcca agatgggcgc cctgctgctg ctgagccacc tgggccgccg ccccacgctg   1260

gccgcatccc tgttgctggc agggctctgc attctggcca acacgctggt gccccacgaa   1320

atgggggctc tgcgctcagc cttggccgtg ctggggctgg gcggggtggg ggctgccttc   1380

acctgcatca ccatctacag cagcgagctc ttccccactg tgctcaggat gacggcagtg   1440

ggcttgggcc agatggcagc ccgtggagga gccatcctgg ggcctctggt ccggctgctg   1500

ggtgtccatg gcccctggct gcccttgctg gtgtatggga cggtgccagt gctgagtggc   1560

ctggccgcac tgcttctgcc cgagacccag agcttgccgc tgcccgacac catccaagat   1620

gtgcagaacc aggcagtaaa gaaggcaaca catggcacgc tggggaactc tgtcctaaaa   1680

tccacacagt tt                                                       1692


<210>  2
<211>  2546
<212>  DNA
<213>  Synthetic

<400>  2
acaagtttgt acaaaaaaga ggcttcgcca ccatggcctt cagcgagctg ctggacctgg     60

tgggaggcct gggcagattc caggtgctgc agaccatggc cctgatggtg tccatcatgt    120

ggctgtgcac ccagagcatg ctggaaaact tctctgccgc cgtgcccagc cacagatgct    180

gggcccctct gctggacaac agcaccgccc aggccagcat cctgggcagc ctgtctccag    240

aggccctgct ggccatcagc atcccccctg gccccaacca gaggccccac cagtgcagac    300

ggttccggca gcctcagtgg cagctgctgg atcccaacgc caccgccacc tcttggagcg    360

aggccgacac cgagccctgt gtggacggct gggtgtacga ccggtccatc ttcaccagca    420

ccatcgtggc caagtggaac ctggtgtgcg acagtcacgc cctgaagccc atggcccaga    480

gcatctacct ggccggcatt ctggtgggag ccgccgcttg tggccctgcc agcgatagat    540

tcggcagacg gctggtgctg acctggtcct acctgcagat ggccgtgatg ggcaccgccg    600

cagcctttgc ccctgccttc cctgtgtact gcctgttccg gttcctgctg gccttcgccg    660

tggccggcgt gatgatgaac accggcaccc tgctgatgga atggaccgcc gccagagcca    720

gacccctggt gatgaccctg aacagcctgg gcttcagctt cggacatggc ctcacagccg    780

ctgtggctta tggcgtgcgg gactggacac tgctgcagct ggtggtgtcc gtgcccttct    840

tcctgtgctt cctgtacagc tggtggctcg ctgagagcgc ccggtggctg ctgaccacag    900

gcagactgga ctggggcctg caggaactgt ggcgggtcgc cgccatcaat ggcaagggcg    960

ccgtgcagga caccctgacc cctgaggtgc tgctgagcgc catgcgcgag gaactgagca   1020

tgggccagcc tccagccagc ctgggcacac tgctgagaat gcccggcctg cggttccgga   1080

cctgcatcag caccctgtgt tggttcgcct tcggcttcac cttcttcggc ctggccctgg   1140

acctccaggc cctgggcagc aacatcttcc tgctgcagat gttcatcggc gtggtggaca   1200

tccccgccaa gatgggcgcc ctgctgctgc tgtctcacct gggcagaagg cctaccctgg   1260

ccgcctctct gctgctggcc ggactgtgca tcctggccaa caccctggtg ccccacgaga   1320

tgggagccct gagatctgcc ctggccgtcc tgggactggg aggcgtggga gctgccttca   1380

cctgtatcac catctacagc agcgagctgt tccccaccgt gctgcggatg acagccgtgg   1440

gcctgggaca gatggccgcc agaggcggag ccatcctggg acctctggtg cgcctgctgg   1500

gagtgcacgg accttggctc cctctgctgg tgtacggcac cgtgcctgtg ctgtctggac   1560

tggctgctct gctgctgccc gagacacaga gcctgcccct gcccgacacc atccaggacg   1620

tgcagaacca ggccgtgaag aaggccaccc acggcaccct gggcaacagc gtgctgaagt   1680

ccacccagtt catggtgtcc aagggggagg aactgtttac cggcgtggtg cccatcctgg   1740

tggaactgga cggcgacgtg aacggccaca agttcagcgt gtccggcgag ggcgaaggcg   1800

acgccaccta cggcaagctg accctgaagt tcatctgcac caccggcaag ctgcccgtgc   1860

cttggcccac cctggtgaca accttcacct acggcgtgca gtgcttcgcc agataccccg   1920

accacatgaa gcagcacgat ttcttcaagt ccgccatgcc cgagggctac gtgcaggaac   1980

ggaccatctt cttcaaggac gacggcaact acaagaccag agccgaagtg aagttcgagg   2040

gcgataccct ggtgaaccgg atcgagctga agggcatcga cttcaaagag gacggcaata   2100

tcctgggcca caagctggag tacaactaca acagccacaa ggtgtacatc accgccgaca   2160

agcagaaaaa cggcatcaaa gtgaacttca agacccggca caacatcgag gacggaagcg   2220

tgcagctggc cgaccactac cagcagaaca cccccatcgg cgacggcccc gtgctgctgc   2280

ctgacaacca ctacctgagc acccagtccg ccctgagcaa ggaccccaac gagaagcggg   2340

accacatggt gctgctggaa ttcgtgaccg ccgctggcat cacactgggc atggacgagc   2400

tgtacaagta cccagctttc ttgtacaaag tggttgatat ccagcacagt ggcggccgct   2460

cgagtctaga gggcccgcgg ttcgaaggta agcctatccc taaccctctc ctcggtctcg   2520

attctacgcg taccggttag taatga                                        2546


<210>  3
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Phe Ser Glu Leu Leu Asp Leu Val Gly Gly Leu Gly Arg Phe 
1               5                   10                  15      


Gln Val Leu Gln Thr Met Ala Leu Met Val Ser Ile Met Trp Leu Cys 
            20                  25                  30          


Thr Gln Ser Met Leu Glu Asn Phe Ser Ala Ala Val Pro Ser His Arg 
        35                  40                  45              


Cys Trp Ala Pro Leu Leu Asp Asn Ser Thr Ala Gln Ala Ser Ile Leu 
    50                  55                  60                  


Gly Ser Leu Ser Pro Glu Ala Leu Leu Ala Ile Ser Ile Pro Pro Gly 
65                  70                  75                  80  


Pro Asn Gln Arg Pro His Gln Cys Arg Arg Phe Arg Gln Pro Gln Trp 
                85                  90                  95      


Gln Leu Leu Asp Pro Asn Ala Thr Ala Thr Ser Trp Ser Glu Ala Asp 
            100                 105                 110         


Thr Glu Pro Cys Val Asp Gly Trp Val Tyr Asp Arg Ser Ile Phe Thr 
        115                 120                 125             


Ser Thr Ile Val Ala Lys Trp Asn Leu Val Cys Asp Ser His Ala Leu 
    130                 135                 140                 


Lys Pro Met Ala Gln Ser Ile Tyr Leu Ala Gly Ile Leu Val Gly Ala 
145                 150                 155                 160 


Ala Ala Cys Gly Pro Ala Ser Asp Arg Phe Gly Arg Arg Leu Val Leu 
                165                 170                 175     


Thr Trp Ser Tyr Leu Gln Met Ala Val Met Gly Thr Ala Ala Ala Phe 
            180                 185                 190         


Ala Pro Ala Phe Pro Val Tyr Cys Leu Phe Arg Phe Leu Leu Ala Phe 
        195                 200                 205             


Ala Val Ala Gly Val Met Met Asn Thr Gly Thr Leu Leu Met Glu Trp 
    210                 215                 220                 


Thr Ala Ala Arg Ala Arg Pro Leu Val Met Thr Leu Asn Ser Leu Gly 
225                 230                 235                 240 


Phe Ser Phe Gly His Gly Leu Thr Ala Ala Val Ala Tyr Gly Val Arg 
                245                 250                 255     


Asp Trp Thr Leu Leu Gln Leu Val Val Ser Val Pro Phe Phe Leu Cys 
            260                 265                 270         


Phe Leu Tyr Ser Trp Trp Leu Ala Glu Ser Ala Arg Trp Leu Leu Thr 
        275                 280                 285             


Thr Gly Arg Leu Asp Trp Gly Leu Gln Glu Leu Trp Arg Val Ala Ala 
    290                 295                 300                 


Ile Asn Gly Lys Gly Ala Val Gln Asp Thr Leu Thr Pro Glu Val Leu 
305                 310                 315                 320 


Leu Ser Ala Met Arg Glu Glu Leu Ser Met Gly Gln Pro Pro Ala Ser 
                325                 330                 335     


Leu Gly Thr Leu Leu Arg Met Pro Gly Leu Arg Phe Arg Thr Cys Ile 
            340                 345                 350         


Ser Thr Leu Cys Trp Phe Ala Phe Gly Phe Thr Phe Phe Gly Leu Ala 
        355                 360                 365             


Leu Asp Leu Gln Ala Leu Gly Ser Asn Ile Phe Leu Leu Gln Met Phe 
    370                 375                 380                 


Ile Gly Val Val Asp Ile Pro Ala Lys Met Gly Ala Leu Leu Leu Leu 
385                 390                 395                 400 


Ser His Leu Gly Arg Arg Pro Thr Leu Ala Ala Ser Leu Leu Leu Ala 
                405                 410                 415     


Gly Leu Cys Ile Leu Ala Asn Thr Leu Val Pro His Glu Met Gly Ala 
            420                 425                 430         


Leu Arg Ser Ala Leu Ala Val Leu Gly Leu Gly Gly Val Gly Ala Ala 
        435                 440                 445             


Phe Thr Cys Ile Thr Ile Tyr Ser Ser Glu Leu Phe Pro Thr Val Leu 
    450                 455                 460                 


Arg Met Thr Ala Val Gly Leu Gly Gln Met Ala Ala Arg Gly Gly Ala 
465                 470                 475                 480 


Ile Leu Gly Pro Leu Val Arg Leu Leu Gly Val His Gly Pro Trp Leu 
                485                 490                 495     


Pro Leu Leu Val Tyr Gly Thr Val Pro Val Leu Ser Gly Leu Ala Ala 
            500                 505                 510         


Leu Leu Leu Pro Glu Thr Gln Ser Leu Pro Leu Pro Asp Thr Ile Gln 
        515                 520                 525             


Asp Val Gln Asn Gln Ala Val Lys Lys Ala Thr His Gly Thr Leu Gly 
    530                 535                 540                 


Asn Ser Val Leu Lys Ser Thr Gln Phe Met Val Ser Lys Gly Glu Glu 
545                 550                 555                 560 


Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val 
                565                 570                 575     


Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr 
            580                 585                 590         


Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro 
        595                 600                 605             


Val Pro Trp Pro Thr Leu Val Thr Thr Phe Thr Tyr Gly Val Gln Cys 
    610                 615                 620                 


Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser 
625                 630                 635                 640 


Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp 
                645                 650                 655     


Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr 
            660                 665                 670         


Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
        675                 680                 685             


Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Lys Val 
    690                 695                 700                 


Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys 
705                 710                 715                 720 


Thr Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr 
                725                 730                 735     


Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn 
            740                 745                 750         


His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys 
        755                 760                 765             


Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
    770                 775                 780                 


Leu Gly Met Asp Glu Leu Tyr Lys Ile Pro Ala Phe Leu Tyr Lys Val 
785                 790                 795                 800 


Val Asn Ile Gln His Ser Gly Gly Arg Ser Ser Leu Glu Gly Pro Arg 
                805                 810                 815     


Phe Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
            820                 825                 830         


Arg Thr Gly 
        835 


