                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  STABLE, PROTRACTED GLP-1/GLUCAGON RECEPTOR CO-AGONISTS

<130>  8676WO01

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  2
<211>  29
<212>  PRT
<213>  Synthetic


<220>
<221>  SITE
<222>  (2)..(2)
<223>  X2 is Aib, Acb or Acpr

<220>
<221>  SITE
<222>  (3)..(3)
<223>  X3 is Gln or His

<220>
<221>  SITE
<222>  (10)..(10)
<223>  X10 is Leu, Ile or Val

<220>
<221>  SITE
<222>  (12)..(12)
<223>  X12 is Lys or Arg

<220>
<221>  SITE
<222>  (15)..(15)
<223>  X15 is Asp or Glu

<220>
<221>  SITE
<222>  (16)..(16)
<223>  X16 is Ser, Ala, Leu, Thr, Glu, Aib, Ile, Val or Lys

<220>
<221>  SITE
<222>  (17)..(17)
<223>  X17 is Arg, or Lys

<220>
<221>  SITE
<222>  (18)..(18)
<223>  X18 is Arg, Ala or Lys

<220>
<221>  SITE
<222>  (20)..(20)
<223>  X20 is Gln, Arg, Glu, Aib or Lys

<220>
<221>  SITE
<222>  (21)..(21)
<223>  X21 is Asp, Glu or Lys

<220>
<221>  SITE
<222>  (24)..(24)
<223>  X24 is Gln, Ala, Arg, Glu, Aib or Lys

<220>
<221>  SITE
<222>  (27)..(27)
<223>  X27 is Met, Leu or Val

<220>
<221>  SITE
<222>  (28)..(28)
<223>  X28 is Asn, Ser, Thr, Gln, Ala, Gly, Glu or Lys

<220>
<221>  SITE
<222>  (29)..(29)
<223>  X29 is Thr, Gly, Ser, Gln, Ala, Glu or Lys

<400>  2

His Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  3
<211>  30
<212>  PRT
<213>  Synthetic


<220>
<221>  SITE
<222>  (2)..(2)
<223>  X2 is Aib, Acb or Acpr

<220>
<221>  SITE
<222>  (3)..(3)
<223>  X3 is Gln or His

<220>
<221>  SITE
<222>  (10)..(10)
<223>  X10 is Leu, Ile or Val

<220>
<221>  SITE
<222>  (12)..(12)
<223>  X12 is Lys or Arg

<220>
<221>  SITE
<222>  (15)..(15)
<223>  X15 is Asp or Glu

<220>
<221>  SITE
<222>  (16)..(16)
<223>  X16 is Ser, Ala, Leu, Thr, Glu, Aib, Ile, Val or Lys

<220>
<221>  SITE
<222>  (17)..(17)
<223>  X17 is Arg, or Lys

<220>
<221>  SITE
<222>  (18)..(18)
<223>  X18 is Arg, Ala or Lys

<220>
<221>  SITE
<222>  (20)..(20)
<223>  X20 is Gln, Arg, Glu, Aib or Lys

<220>
<221>  SITE
<222>  (21)..(21)
<223>  X21 is Asp, Glu or Lys

<220>
<221>  SITE
<222>  (24)..(24)
<223>  X24 is Gln, Ala, Arg, Glu, Aib or Lys

<220>
<221>  SITE
<222>  (27)..(27)
<223>  X27 is Met, Leu or Val

<220>
<221>  SITE
<222>  (28)..(28)
<223>  X28 is Asn, Ser, Thr, Gln, Ala, Gly, Glu or Lys

<220>
<221>  SITE
<222>  (29)..(29)
<223>  X29 is Thr, Gly, Ser, Gln, Ala, Glu or Lys

<220>
<221>  SITE
<222>  (30)..(30)
<223>  X30 is Lys

<400>  3

His Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Trp Leu Xaa Xaa Xaa Xaa 
            20                  25                  30  


<210>  4
<211>  29
<212>  PRT
<213>  Synthetic


<220>
<221>  SITE
<222>  (2)..(2)
<223>  X2 is Aib, Acb or Acpr

<220>
<221>  SITE
<222>  (3)..(3)
<223>  X3 is Gln or His

<220>
<221>  SITE
<222>  (10)..(10)
<223>  X10 is Leu, Ile or Val

<220>
<221>  SITE
<222>  (12)..(12)
<223>  X12 is Lys or Arg

<220>
<221>  SITE
<222>  (15)..(15)
<223>  X15 is Asp or Glu

<220>
<221>  SITE
<222>  (16)..(16)
<223>  X16 is Ser, Ala, Leu, Thr, Glu, Aib, Ile, Val or Lys

<220>
<221>  SITE
<222>  (17)..(17)
<223>  X17 is Arg, or Lys

<220>
<221>  SITE
<222>  (18)..(18)
<223>  X18 is Arg, Ala or Lys

<220>
<221>  SITE
<222>  (20)..(20)
<223>  X20 is Gln, Arg, Glu, Aib or Lys

<220>
<221>  SITE
<222>  (21)..(21)
<223>  X21 is Asp, Glu, Ser or Lys

<220>
<221>  SITE
<222>  (24)..(24)
<223>  X24 is Gln, Ala, Arg, Glu, Aib or Lys

<220>
<221>  SITE
<222>  (27)..(27)
<223>  X27 is Met, Leu or Val

<220>
<221>  SITE
<222>  (28)..(28)
<223>  X28 is Asn, Ser, Thr, Gln, Ala, Gly, Glu or Lys

<220>
<221>  SITE
<222>  (29)..(29)
<223>  X29 is Thr, Gly, Ser, Gln, Ala, Glu or Lys

<400>  4

His Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  5
<211>  30
<212>  PRT
<213>  Synthetic


<220>
<221>  SITE
<222>  (2)..(2)
<223>  X2 is Aib, Acb or Acpr

<220>
<221>  SITE
<222>  (3)..(3)
<223>  X3 is Gln or His

<220>
<221>  SITE
<222>  (10)..(10)
<223>  X10 is Leu, Ile or Val

<220>
<221>  SITE
<222>  (12)..(12)
<223>  X12 is Lys or Arg

<220>
<221>  SITE
<222>  (15)..(15)
<223>  X15 is Asp or Glu

<220>
<221>  SITE
<222>  (16)..(16)
<223>  X16 is Ser, Ala, Leu, Thr, Glu, Aib, Ile, Val or Lys

<220>
<221>  SITE
<222>  (17)..(17)
<223>  X17 is Arg, or Lys

<220>
<221>  SITE
<222>  (18)..(18)
<223>  X18 is Arg, Ala or Lys

<220>
<221>  SITE
<222>  (20)..(20)
<223>  X20 is Gln, Arg, Glu, Aib or Lys

<220>
<221>  SITE
<222>  (21)..(21)
<223>  X21 is Asp, Glu, Ser or Lys

<220>
<221>  SITE
<222>  (24)..(24)
<223>  X24 is Gln, Ala, Arg, Glu, Aib or Lys

<220>
<221>  SITE
<222>  (27)..(27)
<223>  X27 is Met, Leu or Val

<220>
<221>  SITE
<222>  (28)..(28)
<223>  X28 is Asn, Ser, Thr, Gln, Ala, Gly, Glu or Lys

<220>
<221>  SITE
<222>  (29)..(29)
<223>  X29 is Thr, Gly, Ser, Gln, Ala, Glu or Lys

<220>
<221>  SITE
<222>  (30)..(30)
<223>  X30 is Lys

<400>  5

His Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Trp Leu Xaa Xaa Xaa Xaa 
            20                  25                  30  

