                         SEQUENCE LISTING

<110>  Universittsklinikum Hamburg-Eppendorf
       Ruprecht-Karls-Universitt Heidelberg
       Universit Pierre et Marie Curie
       Association Institut de Myologie
 
<120>  GENE-THERAPY VECTORS FOR TREATING CARDIOMYOPATHY

<130>  P 94450

<160>  35     

<170>  PatentIn version 3.5

<210>  1
<211>  4200
<212>  DNA
<213>  Homo sapiens

<400>  1
catggtgagt gcctggtgtg acgtctctca ggatgcctga gccggggaag aagccagtct       60

cagcctttag caagaagcca cggtcagtgg aagtggccgc aggcagccct gccgtgttcg      120

aggccgagac agagcgggca ggagtgaagg tgcgctggca gcgcggaggc agtgacatca      180

gcgccagcaa caagtacggc ctggccacag agggcacacg gcatacgctg acagtgcggg      240

aagtgggccc tgccgaccag ggatcttacg cagtcattgc tggctcctcc aaggtcaagt      300

tcgacctcaa ggtcatagag gcagagaagg cagagcccat gctggcccct gcccctgccc      360

ctgctgaggc cactggagcc cctggagaag ccccggcccc agccgctgag ctgggagaaa      420

gtgccccaag tcccaaaggg tcaagctcag cagctctcaa tggtcctacc cctggagccc      480

ccgatgaccc cattggcctc ttcgtgatgc ggccacagga tggcgaggtg accgtgggtg      540

gcagcatcac cttctcagcc cgcgtggccg gcgccagcct cctgaagccg cctgtggtca      600

agtggttcaa gggcaaatgg gtggacctga gcagcaaggt gggccagcac ctgcagctgc      660

acgacagcta cgaccgcgcc agcaaggtct atctgttcga gctgcacatc accgatgccc      720

agcctgcctt cactggcagc taccgctgtg aggtgtccac caaggacaaa tttgaatgct      780

ccaacttcaa tctcactgtc cacgaggcca tgggcaccgg agacctggac ctcctatcag      840

ccttccgccg cacgagcctg gctggaggtg gtcggcggat cagtgatagc catgaggaca      900

ctgggattct ggacttcagc tcactgctga aaaagagaga cagtttccgg accccgaggg      960

actcgaagct ggaggcacca gcagaggagg acgtgtggga gatcctacgg caggcacccc     1020

catctgagta cgagcgcatc gccttccagt acggcgtcac tgacctgcgc ggcatgctaa     1080

agaggctcaa gggcatgagg cgcgatgaga agaagagcac agcctttcag aagaagctgg     1140

agccggccta ccaggtgagc aaaggccaca agatccggct gaccgtggaa ctggctgacc     1200

atgacgctga ggtcaaatgg ctcaagaatg gccaggagat ccagatgagc ggcagcaagt     1260

acatctttga gtccatcggt gccaagcgta ccctgaccat cagccagtgc tcattggcgg     1320

acgacgcagc ctaccagtgc gtggtgggtg gcgagaagtg tagcacggag ctctttgtga     1380

aagagccccc tgtgctcatc acgcgcccct tggaggacca gctggtgatg gtggggcagc     1440

gggtggagtt tgagtgtgaa gtatcggagg agggggcgca agtcaaatgg ctgaaggacg     1500

gggtggagct gacccgggag gagaccttca aataccggtt caagaaggac gggcagagac     1560

accacctgat catcaacgag gccatgctgg aggacgcggg gcactatgca ctgtgcacta     1620

gcgggggcca ggcgctgcgt gagctcattg tgcaggaaaa gaagctggag gtgtaccaga     1680

gcatcgcaga cctgatggtg ggcgcaaagg accaggcggt gttcaaatgt gaggtctcag     1740

atgagaatgt tcggggtgtg tggctgaaga atgggaagga gctggtgccc gacagccgca     1800

taaaggtgtc ccacatcggg cgggtccaca aactgaccat tgacgacgtc acacctgccg     1860

acgaggctga ctacagcttt gtgcccgagg gcttcgcctg caacctgtca gccaagctcc     1920

acttcatgga ggtcaagatt gacttcgtac ccaggcagga acctcccaag atccacctgg     1980

actgcccagg ccgcatacca gacaccattg tggttgtagc tggaaataag ctacgtctgg     2040

acgtccctat ctctggggac cctgctccca ctgtgatctg gcagaaggct atcacgcagg     2100

ggaataaggc cccagccagg ccagccccag atgccccaga ggacacaggt gacagcgatg     2160

agtgggtgtt tgacaagaag ctgctgtgtg agaccgaggg ccgggtccgc gtggagacca     2220

ccaaggaccg cagcatcttc acggtcgagg gggcagagaa ggaagatgag ggcgtctaca     2280

cggtcacagt gaagaaccct gtgggcgagg accaggtcaa cctcacagtc aaggtcatcg     2340

acgtgccaga cgcacctgcg gcccccaaga tcagcaacgt gggagaggac tcctgcacag     2400

tacagtggga gccgcctgcc tacgatggcg ggcagcccat cctgggctac atcctggagc     2460

gcaagaagaa gaagagctac cggtggatgc agctgaactt cgacctgatt caggagctga     2520

gtcatgaagc gcggcgcatg atcgagggcg tggtgtacga gatgcgcgtc tacgcggtca     2580

acgccatcgg catgtccagg cccagccctg cctcccagcc cttcatgcct atcggtcccc     2640

ccagcgaacc cacccacctg gcagtagagg acgtctctga caccacggtc tccctcaagt     2700

ggcggccccc agagcgcgtg ggagcaggag gcctggatgg ctacagcgtg gagtactgcc     2760

cagagggctg ctcagagtgg gtggctgccc tgcaggggct gacagagcac acatcgatac     2820

tggtgaagga cctgcccacg ggggcccggc tgcttttccg agtgcgggca cacaatatgg     2880

cagggcctgg agcccctgtt accaccacgg agccggtgac agtgcaggag atcctgcaac     2940

ggccacggct tcagctgccc aggcacctgc gccagaccat tcagaagaag gtcggggagc     3000

ctgtgaacct tctcatccct ttccagggca agccccggcc tcaggtgacc tggaccaaag     3060

aggggcagcc cctggcaggc gaggaggtga gcatccgcaa cagccccaca gacaccatcc     3120

tgttcatccg ggccgctcgc cgcgtgcatt caggcactta ccaggtgacg gtgcgcattg     3180

agaacatgga ggacaaggcc acgctggtgc tgcaggttgt tgacaagcca agtcctcccc     3240

aggatctccg ggtgactgac gcctggggtc ttaatgtggc tctggagtgg aagccacccc     3300

aggatgtcgg caacacggaa ctctgggggt acacagtgca gaaagccgac aagaagacca     3360

tggagtggtt caccgtcttg gagcattacc gccgcaccca ctgcgtggtg ccagagctca     3420

tcattggcaa tggctactac ttccgcgtct tcagccagaa tatggttggc tttagtgaca     3480

gagcggccac caccaaggag cccgtcttta tccccagacc aggcatcacc tatgagccac     3540

ccaactataa ggccctggac ttctccgagg ccccaagctt cacccagccc ctggtgaacc     3600

gctcggtcat cgcgggctac actgctatgc tctgctgtgc tgtccggggt agccccaagc     3660

ccaagatttc ctggttcaag aatggcctgg acctgggaga agacgcccgc ttccgcatgt     3720

tcagcaagca gggagtgttg actctggaga ttagaaagcc ctgccccttt gacgggggca     3780

tctatgtctg cagggccacc aacttacagg gcgaggcacg gtgtgagtgc cgcctggagg     3840

tgcgagtgcc tcagtgacca ggctggctcc tggggatggc caggtacaac cggatgccag     3900

ccccgtgcca ggagcctgga gggaagttgg ggaaacccct ccctactgtt ggatgtatgt     3960

gtgacaagtg tgtctcctgt gctgcgatgg gggatcagca gggcagttgt cgggcagtcc     4020

tgagtgggtg ttgcacagac tggtccacag ggctcctgaa ggaagcccct ggatctttgg     4080

ggtaaaagga gggtggcctc aagaaacaat gtctggggac aggcctttct ggcctgctat     4140

gtcttcccaa tgtttattgg gcaataaaag ataagtgcag tcacagagaa ctcactcttc     4200


<210>  2
<211>  1274
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro 
1               5                   10                  15      


Arg Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu 
            20                  25                  30          


Thr Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp 
        35                  40                  45              


Ile Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His 
    50                  55                  60                  


Thr Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala 
65                  70                  75                  80  


Val Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu 
                85                  90                  95      


Ala Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu 
            100                 105                 110         


Ala Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly 
        115                 120                 125             


Glu Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly 
    130                 135                 140                 


Pro Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg 
145                 150                 155                 160 


Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala 
                165                 170                 175     


Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe 
            180                 185                 190         


Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln 
        195                 200                 205             


Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu 
    210                 215                 220                 


His Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu 
225                 230                 235                 240 


Val Ser Thr Lys Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val 
                245                 250                 255     


His Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg 
            260                 265                 270         


Arg Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu 
        275                 280                 285             


Asp Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser 
    290                 295                 300                 


Phe Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp 
305                 310                 315                 320 


Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile 
                325                 330                 335     


Ala Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu 
            340                 345                 350         


Lys Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys 
        355                 360                 365             


Leu Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr 
    370                 375                 380                 


Val Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly 
385                 390                 395                 400 


Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly 
                405                 410                 415     


Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala 
            420                 425                 430         


Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe 
        435                 440                 445             


Val Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu 
    450                 455                 460                 


Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu 
465                 470                 475                 480 


Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu 
                485                 490                 495     


Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu 
            500                 505                 510         


Ile Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys 
        515                 520                 525             


Thr Ser Gly Gly Gln Ala Leu Ala Glu Leu Ile Val Gln Glu Lys Lys 
    530                 535                 540                 


Leu Glu Val Tyr Gln Ser Ile Ala Asp Leu Met Val Gly Ala Lys Asp 
545                 550                 555                 560 


Gln Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val Arg Gly Val 
                565                 570                 575     


Trp Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Ser Arg Ile Lys Val 
            580                 585                 590         


Ser His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp Val Thr Pro 
        595                 600                 605             


Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe Ala Cys Asn 
    610                 615                 620                 


Leu Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp Phe Val Pro 
625                 630                 635                 640 


Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro 
                645                 650                 655     


Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro 
            660                 665                 670         


Ile Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr 
        675                 680                 685             


Gln Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp 
    690                 695                 700                 


Thr Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu 
705                 710                 715                 720 


Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe 
                725                 730                 735     


Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr 
            740                 745                 750         


Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val 
        755                 760                 765             


Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly 
    770                 775                 780                 


Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly 
785                 790                 795                 800 


Gln Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr 
                805                 810                 815     


Arg Trp Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu 
            820                 825                 830         


Ala Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala 
        835                 840                 845             


Val Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe 
    850                 855                 860                 


Met Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp 
865                 870                 875                 880 


Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val 
                885                 890                 895     


Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly 
            900                 905                 910         


Cys Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser 
        915                 920                 925             


Ile Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val 
    930                 935                 940                 


Arg Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu 
945                 950                 955                 960 


Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro 
                965                 970                 975     


Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn 
            980                 985                 990         


Leu Leu Ile Pro Phe Gln Gly Lys  Pro Arg Pro Gln Val  Thr Trp Thr 
        995                 1000                 1005             


Lys Glu  Gly Gln Pro Leu Ala  Gly Glu Glu Val Ser  Ile Arg Asn 
    1010                 1015                 1020             


Ser Pro  Thr Asp Thr Ile Leu  Phe Ile Arg Ala Ala  Arg Arg Val 
    1025                 1030                 1035             


His Ser  Gly Thr Tyr Gln Val  Thr Val Arg Ile Glu  Asn Met Glu 
    1040                 1045                 1050             


Asp Lys  Ala Thr Leu Val Leu  Gln Val Val Asp Lys  Pro Ser Pro 
    1055                 1060                 1065             


Pro Gln  Asp Leu Arg Val Thr  Asp Ala Trp Gly Leu  Asn Val Ala 
    1070                 1075                 1080             


Leu Glu  Trp Lys Pro Pro Gln  Asp Val Gly Asn Thr  Glu Leu Trp 
    1085                 1090                 1095             


Gly Tyr  Thr Val Gln Lys Ala  Asp Lys Lys Thr Met  Glu Trp Phe 
    1100                 1105                 1110             


Thr Val  Leu Glu His Tyr Arg  Arg Thr His Cys Val  Val Pro Glu 
    1115                 1120                 1125             


Leu Ile  Ile Gly Asn Gly Tyr  Tyr Phe Arg Val Phe  Ser Gln Asn 
    1130                 1135                 1140             


Met Val  Gly Phe Ser Asp Arg  Ala Ala Thr Thr Lys  Glu Pro Val 
    1145                 1150                 1155             


Phe Ile  Pro Arg Pro Gly Ile  Thr Tyr Glu Pro Pro  Asn Tyr Lys 
    1160                 1165                 1170             


Ala Leu  Asp Phe Ser Glu Ala  Pro Ser Phe Thr Gln  Pro Leu Val 
    1175                 1180                 1185             


Asn Arg  Ser Val Ile Ala Gly  Tyr Thr Ala Met Leu  Cys Cys Ala 
    1190                 1195                 1200             


Val Arg  Gly Ser Pro Lys Pro  Lys Ile Ser Trp Phe  Lys Asn Gly 
    1205                 1210                 1215             


Leu Asp  Leu Gly Glu Asp Ala  Arg Phe Arg Met Phe  Ser Lys Gln 
    1220                 1225                 1230             


Gly Val  Leu Thr Leu Glu Ile  Arg Lys Pro Cys Pro  Phe Asp Gly 
    1235                 1240                 1245             


Gly Ile  Tyr Val Cys Arg Ala  Thr Asn Leu Gln Gly  Glu Ala Arg 
    1250                 1255                 1260             


Cys Glu  Cys Arg Leu Glu Val  Arg Val Pro Gln 
    1265                 1270                 


<210>  3
<211>  4163
<212>  DNA
<213>  Mus musculus

<400>  3
agtccctcct tgggtggcct gcttgatgcc tggtgtgact gttctcaaga tgccggagcc       60

agggaagaaa ccagtgtcag ccttcaacaa gaagccaagg tcagcggagg tgaccgctgg      120

cagtgctgcc gtgttcgagg ctgagacgga gcggtcaggc gtgaaggtgc ggtggcagcg      180

ggatggcagc gacatcaccg ccaatgacaa gtatggtttg gcagcagagg gcaagcgaca      240

cacactgaca gtgcgggatg cgagccctga tgaccagggt tcctacgcgg tcattgcagg      300

ctcctcaaag gtcaagtttg acctcaaggt cacagagcca gcccctccag agaaggcaga      360

atctgaagtt gctccaggag cccccaaaga agtccctgct ccagccactg agttggaaga      420

aagtgtctca agtcctgaag ggtcagtctc ggtaacccag gatggctcag ctgcagagca      480

tcagggagcc cctgatgacc ctattggcct ctttctgatg cgaccacagg atggtgaggt      540

gaccgtgggc ggcagcattg tcttctcagc ccgagtggct ggggccagcc tcctgaaacc      600

gcctgtggtc aagtggttca agggcaagtg ggtggacctg agcagcaaag tgggccagca      660

cctgcagctg catgacagct atgacagagc cagcaaggtc tacttgtttg agttgcacat      720

cacagatgct cagaccactt ctgctggggg ctaccgctgt gaggtgtcta ccaaggacaa      780

atttgacagc tgtaacttca acctcactgt ccatgaggcc attggttctg gagacctgga      840

cctcagatca gctttccgac gcacgagcct ggcgggagca ggtcggagaa ccagtgacag      900

ccatgaagat gctgggactc tggactttag ttccctgctg aagaagagag acagtttccg      960

gagggactca aagctggagg cacctgctga agaagacgtg tgggagatcc tgagacaggc     1020

accgccgtca gaatatgagc gcatcgcctt ccagcacgga gtcacagacc ttcgaggcat     1080

gctgaagagg ctcaagggca tgaagcagga tgaaaagaag agcacagcct ttcagaagaa     1140

gctggagcct gcctaccagg taaacaaggg ccacaagatt cggcttactg tggaactggc     1200

tgatccggac gccgaagtca agtggcttaa gaatggacag gagatccaga tgagtggcag     1260

caagtacatc ttcgagtccg tcggtgccaa gcgcaccctg accatcagcc agtgctcact     1320

ggctgacgac gcagcctacc agtgtgtggt ggggggcgag aagtgcagca cggagctctt     1380

tgtcaaagag cccccggtgc tgatcactcg gtccctggaa gaccagctgg tgatggtggg     1440

tcagcgggtg gagtttgagt gtgaggtctc agaagaaggg gcccaagtca aatggctgaa     1500

ggatggggtt gagctgacac gtgaggagac cttcaaatac cggttcaaga aagatgggcg     1560

gaaacaccac ttgatcatca atgaagcaac cctggaggat gcaggacact atgcagtacg     1620

cacaagtgga ggccagtcac tggctgagct cattgtgcaa gagaagaagt tggaggtata     1680

ccaaagcatc gcggacctgg cagtgggagc caaggaccag gctgtgttta agtgtgaggt     1740

ttcagatgag aatgtacgcg gcgtgtggct gaagaatggg aaggaactgg tgcctgacaa     1800

ccgcataaag gtgtcccata taggccgggt ccacaaactg accattgacg atgtcacacc     1860

tgctgatgag gctgactaca gctttgtccc tgaagggttt gcctgcaacc tgtctgccaa     1920

gctccacttc atggaggtca agattgactt tgtgcctagg caggaacctc ccaagatcca     1980

cttggattgt cccggcagca caccagacac cattgtggtt gttgctggga acaagttacg     2040

cctggatgtc cctatttctg gagaccctgc tcccactgtg gtctggcaga agactgtaac     2100

acaggggaag aaggcctcaa ctgggccaca ccctgatgcc ccagaagatg ctggtgctga     2160

tgaggagtgg gtgtttgata agaagctgtt gtgtgagact gagggccggg tccgggtgga     2220

gaccaccaaa gaccgcagcg tctttacagt cgaaggggca gagaaggaag atgaaggtgt     2280

ctacacagtc acagtaaaga accccgtggg cgaggaccag gtcaacctca cagtcaaggt     2340

catcgatgtc ccagatgctc ctgcggcccc taagatcagc aacgtgggcg aggactcctg     2400

cactgtgcag tgggaaccgc ctgcctatga tggcgggcag ccggtcctgg gatacatcct     2460

ggagcgcaag aagaaaaaga gctacaggtg gatgaggctc aactttgatc tgctgcggga     2520

gctgagccac gaggcgaggc gcatgatcga gggtgtagcc tatgagatgc gagtctacgc     2580

agtcaatgcc gtgggaatgt ccaggcccag ccctgcctct cagcccttca tgcctattgg     2640

gccccctggc gaaccaaccc acttggctgt ggaggatgtg tcagacacca ctgtctcact     2700

caagtggcgg cccccagagc gcgtgggggc cggtggcctg gacggataca gcgtggagta     2760

ctgccaggag ggatgctccg agtggacacc tgctctgcag gggctgacag agcgcacatc     2820

gatgctggtg aaggacctac ccactggggc acggctgctg ttccgagtac gggcacacaa     2880

tgtggcaggt cctggaggcc ctatcgtcac caaggagcct gtgacagtgc aggagatact     2940

gcaacgacca cggctccaac tgcccagaca cctgcgccag accatccaga agaaagttgg     3000

ggagcctgtg aacctcctca tccctttcca gggcaaaccc cggcctcagg tgacctggac     3060

caaagagggg cagcccctgg caggtgagga ggtgagcatc cggaacagcc ccacagacac     3120

gatcttgttc atccgagctg cccgccgcac ccactcgggc acctaccagg tgacagttcg     3180

cattgagaac atggaggaca aggcaacgct gatcctgcag attgtggaca agccaagtcc     3240

tccccaggat atccggatcg ttgagacttg gggtttcaat gtggctctgg agtggaagcc     3300

accccaagat gatggcaata cagagatctg gggttatact gtacagaaag ctgacaagaa     3360

gaccatggag tggttcacgg ttttggaaca ctaccgacgc actcactgtg tggtatcaga     3420

gcttatcatt ggcaatggct actacttccg ggtcttcagc cataacatgg tgggttccag     3480

tgacaaagct gccgccacca aggagccagt ctttattcca agaccaggca tcacatatga     3540

gccacccaaa tacaaggccc tggacttctc tgaggcccca agcttcaccc agcccttggc     3600

aaatcgctcc atcattgcag gctataatgc catcctctgc tgtgctgtcc gaggtagtcc     3660

taagcccaag atttcctggt tcaagaatgg cctggatctg ggagaagatg ctcgcttccg     3720

catgttctgc aagcagggag tattgaccct ggagatcagg aaaccctgcc cctatgatgg     3780

tggtgtctat gtctgcaggg ccaccaactt gcagggcgag gcacagtgtg agtgccgcct     3840

ggaggtgcga gttcctcagt gaccaggatg gctccccaga gatggctagg tacaaatgga     3900

tgccaggctg tgtaccagac cggaagggag ttggaggagc acccttttct gctactgcat     3960

gtgtgtgtgc aactgtgcat cctggaagga ctggccagca gtgacaccag gcaggtctgc     4020

tgggttctga agaaactgac cctaaggata atgttaatac tgggagcata aagtgtgtgg     4080

gcttcagaag tggtgactgg ggacaggccc ttttggctgg ctcattgtgt aggagcaata     4140

aaagatctgt gccattcctg ggg                                             4163


<210>  4
<211>  1278
<212>  PRT
<213>  Mus musculus

<400>  4

Met Pro Gly Val Thr Val Leu Lys Met Pro Glu Pro Gly Lys Lys Pro 
1               5                   10                  15      


Val Ser Ala Phe Asn Lys Lys Pro Arg Ser Ala Glu Val Thr Ala Gly 
            20                  25                  30          


Ser Ala Ala Val Phe Glu Ala Glu Thr Glu Arg Ser Gly Val Lys Val 
        35                  40                  45              


Arg Trp Gln Arg Asp Gly Ser Asp Ile Thr Ala Asn Asp Lys Tyr Gly 
    50                  55                  60                  


Leu Ala Ala Glu Gly Lys Arg His Thr Leu Thr Val Arg Asp Ala Ser 
65                  70                  75                  80  


Pro Asp Asp Gln Gly Ser Tyr Ala Val Ile Ala Gly Ser Ser Lys Val 
                85                  90                  95      


Lys Phe Asp Leu Lys Val Thr Glu Pro Ala Pro Pro Glu Lys Ala Glu 
            100                 105                 110         


Ser Glu Val Ala Pro Gly Ala Pro Lys Glu Val Pro Ala Pro Ala Thr 
        115                 120                 125             


Glu Leu Glu Glu Ser Val Ser Ser Pro Glu Gly Ser Val Ser Val Thr 
    130                 135                 140                 


Gln Asp Gly Ser Ala Ala Glu His Gln Gly Ala Pro Asp Asp Pro Ile 
145                 150                 155                 160 


Gly Leu Phe Leu Met Arg Pro Gln Asp Gly Glu Val Thr Val Gly Gly 
                165                 170                 175     


Ser Ile Val Phe Ser Ala Arg Val Ala Gly Ala Ser Leu Leu Lys Pro 
            180                 185                 190         


Pro Val Val Lys Trp Phe Lys Gly Lys Trp Val Asp Leu Ser Ser Lys 
        195                 200                 205             


Val Gly Gln His Leu Gln Leu His Asp Ser Tyr Asp Arg Ala Ser Lys 
    210                 215                 220                 


Val Tyr Leu Phe Glu Leu His Ile Thr Asp Ala Gln Thr Thr Ser Ala 
225                 230                 235                 240 


Gly Gly Tyr Arg Cys Glu Val Ser Thr Lys Asp Lys Phe Asp Ser Cys 
                245                 250                 255     


Asn Phe Asn Leu Thr Val His Glu Ala Ile Gly Ser Gly Asp Leu Asp 
            260                 265                 270         


Leu Arg Ser Ala Phe Arg Arg Thr Ser Leu Ala Gly Ala Gly Arg Arg 
        275                 280                 285             


Thr Ser Asp Ser His Glu Asp Ala Gly Thr Leu Asp Phe Ser Ser Leu 
    290                 295                 300                 


Leu Lys Lys Arg Asp Ser Phe Arg Arg Asp Ser Lys Leu Glu Ala Pro 
305                 310                 315                 320 


Ala Glu Glu Asp Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu 
                325                 330                 335     


Tyr Glu Arg Ile Ala Phe Gln His Gly Val Thr Asp Leu Arg Gly Met 
            340                 345                 350         


Leu Lys Arg Leu Lys Gly Met Lys Gln Asp Glu Lys Lys Ser Thr Ala 
        355                 360                 365             


Phe Gln Lys Lys Leu Glu Pro Ala Tyr Gln Val Asn Lys Gly His Lys 
    370                 375                 380                 


Ile Arg Leu Thr Val Glu Leu Ala Asp Pro Asp Ala Glu Val Lys Trp 
385                 390                 395                 400 


Leu Lys Asn Gly Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe 
                405                 410                 415     


Glu Ser Val Gly Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu 
            420                 425                 430         


Ala Asp Asp Ala Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser 
        435                 440                 445             


Thr Glu Leu Phe Val Lys Glu Pro Pro Val Leu Ile Thr Arg Ser Leu 
    450                 455                 460                 


Glu Asp Gln Leu Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu 
465                 470                 475                 480 


Val Ser Glu Glu Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu 
                485                 490                 495     


Leu Thr Arg Glu Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Arg 
            500                 505                 510         


Lys His His Leu Ile Ile Asn Glu Ala Thr Leu Glu Asp Ala Gly His 
        515                 520                 525             


Tyr Ala Val Arg Thr Ser Gly Gly Gln Ser Leu Ala Glu Leu Ile Val 
    530                 535                 540                 


Gln Glu Lys Lys Leu Glu Val Tyr Gln Ser Ile Ala Asp Leu Ala Val 
545                 550                 555                 560 


Gly Ala Lys Asp Gln Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn 
                565                 570                 575     


Val Arg Gly Val Trp Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Asn 
            580                 585                 590         


Arg Ile Lys Val Ser His Ile Gly Arg Val His Lys Leu Thr Ile Asp 
        595                 600                 605             


Asp Val Thr Pro Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly 
    610                 615                 620                 


Phe Ala Cys Asn Leu Ser Ala Lys Leu His Phe Met Glu Val Lys Ile 
625                 630                 635                 640 


Asp Phe Val Pro Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro 
                645                 650                 655     


Gly Ser Thr Pro Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg 
            660                 665                 670         


Leu Asp Val Pro Ile Ser Gly Asp Pro Ala Pro Thr Val Val Trp Gln 
        675                 680                 685             


Lys Thr Val Thr Gln Gly Lys Lys Ala Ser Thr Gly Pro His Pro Asp 
    690                 695                 700                 


Ala Pro Glu Asp Ala Gly Ala Asp Glu Glu Trp Val Phe Asp Lys Lys 
705                 710                 715                 720 


Leu Leu Cys Glu Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp 
                725                 730                 735     


Arg Ser Val Phe Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val 
            740                 745                 750         


Tyr Thr Val Thr Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu 
        755                 760                 765             


Thr Val Lys Val Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile 
    770                 775                 780                 


Ser Asn Val Gly Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala 
785                 790                 795                 800 


Tyr Asp Gly Gly Gln Pro Val Leu Gly Tyr Ile Leu Glu Arg Lys Lys 
                805                 810                 815     


Lys Lys Ser Tyr Arg Trp Met Arg Leu Asn Phe Asp Leu Leu Arg Glu 
            820                 825                 830         


Leu Ser His Glu Ala Arg Arg Met Ile Glu Gly Val Ala Tyr Glu Met 
        835                 840                 845             


Arg Val Tyr Ala Val Asn Ala Val Gly Met Ser Arg Pro Ser Pro Ala 
    850                 855                 860                 


Ser Gln Pro Phe Met Pro Ile Gly Pro Pro Gly Glu Pro Thr His Leu 
865                 870                 875                 880 


Ala Val Glu Asp Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro 
                885                 890                 895     


Pro Glu Arg Val Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr 
            900                 905                 910         


Cys Gln Glu Gly Cys Ser Glu Trp Thr Pro Ala Leu Gln Gly Leu Thr 
        915                 920                 925             


Glu Arg Thr Ser Met Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu 
    930                 935                 940                 


Leu Phe Arg Val Arg Ala His Asn Val Ala Gly Pro Gly Gly Pro Ile 
945                 950                 955                 960 


Val Thr Lys Glu Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg 
                965                 970                 975     


Leu Gln Leu Pro Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly 
            980                 985                 990         


Glu Pro Val Asn Leu Leu Ile Pro  Phe Gln Gly Lys Pro  Arg Pro Gln 
        995                 1000                 1005             


Val Thr  Trp Thr Lys Glu Gly  Gln Pro Leu Ala Gly  Glu Glu Val 
    1010                 1015                 1020             


Ser Ile  Arg Asn Ser Pro Thr  Asp Thr Ile Leu Phe  Ile Arg Ala 
    1025                 1030                 1035             


Ala Arg  Arg Thr His Ser Gly  Thr Tyr Gln Val Thr  Val Arg Ile 
    1040                 1045                 1050             


Glu Asn  Met Glu Asp Lys Ala  Thr Leu Ile Leu Gln  Ile Val Asp 
    1055                 1060                 1065             


Lys Pro  Ser Pro Pro Gln Asp  Ile Arg Ile Val Glu  Thr Trp Gly 
    1070                 1075                 1080             


Phe Asn  Val Ala Leu Glu Trp  Lys Pro Pro Gln Asp  Asp Gly Asn 
    1085                 1090                 1095             


Thr Glu  Ile Trp Gly Tyr Thr  Val Gln Lys Ala Asp  Lys Lys Thr 
    1100                 1105                 1110             


Met Glu  Trp Phe Thr Val Leu  Glu His Tyr Arg Arg  Thr His Cys 
    1115                 1120                 1125             


Val Val  Ser Glu Leu Ile Ile  Gly Asn Gly Tyr Tyr  Phe Arg Val 
    1130                 1135                 1140             


Phe Ser  His Asn Met Val Gly  Ser Ser Asp Lys Ala  Ala Ala Thr 
    1145                 1150                 1155             


Lys Glu  Pro Val Phe Ile Pro  Arg Pro Gly Ile Thr  Tyr Glu Pro 
    1160                 1165                 1170             


Pro Lys  Tyr Lys Ala Leu Asp  Phe Ser Glu Ala Pro  Ser Phe Thr 
    1175                 1180                 1185             


Gln Pro  Leu Ala Asn Arg Ser  Ile Ile Ala Gly Tyr  Asn Ala Ile 
    1190                 1195                 1200             


Leu Cys  Cys Ala Val Arg Gly  Ser Pro Lys Pro Lys  Ile Ser Trp 
    1205                 1210                 1215             


Phe Lys  Asn Gly Leu Asp Leu  Gly Glu Asp Ala Arg  Phe Arg Met 
    1220                 1225                 1230             


Phe Cys  Lys Gln Gly Val Leu  Thr Leu Glu Ile Arg  Lys Pro Cys 
    1235                 1240                 1245             


Pro Tyr  Asp Gly Gly Val Tyr  Val Cys Arg Ala Thr  Asn Leu Gln 
    1250                 1255                 1260             


Gly Glu  Ala Gln Cys Glu Cys  Arg Leu Glu Val Arg  Val Pro Gln 
    1265                 1270                 1275             


<210>  5
<211>  544
<212>  DNA
<213>  Homo sapiens

<400>  5
ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt       60

ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag      120

tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg      180

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac      240

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      300

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      360

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      420

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      480

tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca ggatctgtcg      540

gcag                                                                   544


<210>  6
<211>  222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polyadenylation signal

<400>  6
cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa       60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca      120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggagatgt      180

gggaggtttt ttaaagcaag taaaacctct acaaatgtgg ta                         222


<210>  7
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric intron

<400>  7
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  8
<211>  9026
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector construct

<400>  8
ctagaattca cgcgtctcag tccattagga gccagtagcc tggaagatgt ctttaccccc       60

agcatcagtt caagtggagc agcacataac tcttgccctc tgccttccaa gattctggtg      120

ctgagactta tggagtgtct tggaggttgc cttctgcccc ccaaccctgc tcccagctgg      180

ccctcccagg cctgggttgc tggcctctgc tttatcagga ttctcaagag ggacagctgg      240

tttatgttgc atgactgttc cctgcatatc tgctctggtt ttaaatagct tatctgagca      300

gctggaggac cacatgggct tatatggcgt ggggtacatg ttcctgtagc cttgtccctg      360

gcacctgcca aaatagcagc caacaccccc cacccccacc gccatccccc tgccccaccc      420

gtcccctgtc gcacattcct ccctccgcag ggctggctca ccaggcccca gcccacatgc      480

ctgcttaaag ccctctccat cctctgcctc acccagtccc cgctgagact gagcagacgc      540

ctccaggatc tgtcggcaga agctttattg cggtagttta tcacagttaa attgctaacg      600

cagtcagtgc ttctgacaca acagtctcga acttaagctg cagaagttgg tcgtgaggca      660

ctgggcaggt aagtatcaag gttacaagac aggtttaagg agaccaatag aaactgggct      720

tgtcgagaca gagaagactc ttgcgtttct gataggcacc tattggtctt actgacatcc      780

actttgcctt tctctccaca ggtgtccact cccagttcaa ttacagctct taaggctaga      840

gtacttaata cgactcacta taggctagcc tcgagatgga ttacaaggat gacgacgata      900

agcctggtgt gactgttctc aagatgccgg agccagggaa gaaaccagtg tcagccttca      960

acaagaagcc aaggtcagcg gaggtgaccg ctggcagtgc tgccgtgttc gaggctgaga     1020

cggagcggtc aggcgtgaag gtgcggtggc agcgggatgg cagcgacatc accgccaatg     1080

acaagtatgg tttggcagca gagggcaagc gacacacact gacagtgcgg gatgcgagcc     1140

ctgatgacca gggttcctac gcggtcattg caggctcctc aaaggtcaag tttgacctca     1200

aggtcacaga gccagcccct ccagagaagg cagaatctga agttgctcca ggagccccca     1260

aagaagtccc tgctccagcc actgagttgg aagaaagtgt ctcaagtcct gaaggtcagt     1320

ctcggtaacc caggatggct cagctgcaga gcatcaggga gcccctgatg accctattgg     1380

cctctttctg atgcgaccac aggatggtga ggtgaccgtg ggcggcagca ttgtcttctc     1440

agcccgagtg gctggggcca gcctcctgaa accgcctgtg gtcaagtggt tcaagggcaa     1500

gtgggtggac ctgagcagca aagtgggcca gcacctgcag ctgcatgaca gctatgacag     1560

agccagcaag gtctacttgt ttgagttgca catcacagat gctcagacca cttctgctgg     1620

gggctaccgc tgtgaggtgt ctaccaagga caaatttgac agctgtaact tcaacctcac     1680

tgtccatgag gccattggtt ctggagacct ggacctcaga tcagctttcc gacgcacgag     1740

cctggcggga gcaggtcgga gaaccagtga cagccatgaa gatgctggga ctctggactt     1800

tagttccctg ctgaagaaga gagacagttt ccggagggac tcaaagctgg aggcacctgc     1860

tgaagaagac gtgtgggaga tcctgagaca ggcaccgccg tcagaatatg agcgcatcgc     1920

cttccagcac ggagtcacag accttcgagg catgctgaag aggctcaagg gcatgaagca     1980

ggatgaaaag aagagcacag cctttcagaa gaagctggag cctgcctacc aggtaaacaa     2040

gggccacaag attcggctta ctgtggaact ggctgatccg gacgccgaag tcaagtggct     2100

taagaatgga caggagatcc agatgagtgg cagcaagtac atcttcgagt ccgtcggtgc     2160

caagcgcacc ctgaccatca gccagtgctc actggctgac gacgcagcct accagtgtgt     2220

ggtggggggc gagaagtgca gcacggagct ctttgtcaaa gagcccccgg tgctgatcac     2280

tcggtccctg gaagaccagc tggtgatggt gggtcagcgg gtggagtttg agtgtgaggt     2340

ctcagaagaa ggggcccaag tcaaatggct gaaggatggg gttgagctga cacgtgagga     2400

gaccttcaaa taccggttca agaaagatgg gcggaaacac cacttgatca tcaatgaagc     2460

aaccctggag gatgcaggac actatgcagt acgcacaagt ggaggccagt cactggctga     2520

gctcattgtg caagagaaga agttggaggt ataccaaagc atcgcggacc tggcagtggg     2580

agccaaggac caggctgtgt ttaagtgtga ggtttcagat gagaatgtac gcggcgtgtg     2640

gctgaagaat gggaaggaac tggtgcctga caaccgcata aaggtgtccc atataggccg     2700

ggtccacaaa ctgaccattg acgatgtcac acctgctgat gaggctgact acagctttgt     2760

ccctgaaggg tttgcctgca acctgtctgc caagctccac ttcatggagg tcaagattga     2820

ctttgtgcct aggcaggaac ctcccaagat ccacttggat tgtcccggca gcacaccaga     2880

caccattgtg gttgttgctg ggaacaagtt acgcctggat gtccctattt ctggagaccc     2940

tgctcccact gtggtctggc agaagactgt aacacagggg aagaaggcct caactgggcc     3000

acaccctgat gccccagaag atgctggtgc tgatgaggag tgggtgtttg ataagaagct     3060

gttgtgtgag actgagggcc gggtccgggt ggagaccacc aaagaccgca gcgtctttac     3120

agtcgaaggg gcagagaagg aagatgaagg tgtctacaca gtcacagtaa agaaccccgt     3180

gggcgaggac caggtcaacc tcacagtcaa ggtcatcgat gtcccagatg ctcctgcggc     3240

ccctaagatc agcaacgtgg gcgaggactc ctgcactgtg cagtgggaac cgcctgccta     3300

tgatggcggg cagccggtcc tgggatacat cctggagcgc aagaagaaaa agagctacag     3360

gtggatgagg ctcaactttg atctgctgcg ggagctgagc cacgaggcga ggcgcatgat     3420

cgagggtgta gcctatgaga tgcgagtcta cgcagtcaat gccgtgggaa tgtccaggcc     3480

cagccctgcc tctcagccct tcatgcctat tgggccccct ggcgaaccaa cccacttggc     3540

tgtggaggat gtgtcagaca ccactgtctc actcaagtgg cggcccccag agcgcgtggg     3600

ggccggtggc ctggacggat acagcgtgga gtactgccag gagggatgct ccgagtggac     3660

acctgctctg caggggctga cagagcgcac atcgatgctg gtgaaggacc tacccactgg     3720

ggcacggctg ctgttccgag tacgggcaca caatgtggca ggtcctggag gccctatcgt     3780

caccaaggag cctgtgacag tgcaggagat actgcaacga ccacggctcc aactgcccag     3840

acacctgcgc cagaccatcc agaagaaagt tggggagcct gtgaacctcc tcatcccttt     3900

ccagggcaaa ccccggcctc aggtgacctg gaccaaagag gggcagcccc tggcaggtga     3960

ggaggtgagc atccggaaca gccccacaga cacgatcttg ttcatccgag ctgcccgccg     4020

cacccactcg ggcacctacc aggtgacagt tcgcattgag aacatggagg acaaggcaac     4080

gctgatcctg cagattgtgg acaagccaag tcctccccag gatatccgga tcgttgagac     4140

ttggggtttc aatgtggctc tggagtggaa gccaccccaa gatgatggca atacagagat     4200

ctggggttat actgtacaga aagctgacaa gaagaccatg gagtggttca cggttttgga     4260

acactaccga cgcactcact gtgtggtatc agagcttatc attggcaatg gctactactt     4320

ccgggtcttc agccataaca tggtgggttc cagtgacaaa gctgccgcca ccaaggagcc     4380

agtctttatt ccaagaccag gcatcacata tgagccaccc aaatacaagg ccctggactt     4440

ctctgaggcc ccaagcttca cccagccctt ggcaaatcgc tccatcattg caggctataa     4500

tgccatcctc tgctgtgctg tccgaggtag tcctaagccc aagatttcct ggttcaagaa     4560

tggcctggat ctgggagaag atgctcgctt ccgcatgttc tgcaagcagg gagtattgac     4620

cctggagatc aggaaaccct gcccctatga tggtggtgtc tatgtctgca gggccaccaa     4680

cttgcagggc gaggcacagt gtgagtgccg cctggaggtg cgagttcctc agtgaccagg     4740

gatccgtcga cgcggccgct tccctttagt gagggttaat gcttcgagca gacatgataa     4800

gatacattga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt     4860

gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta     4920

acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggagatgtgg gaggtttttt     4980

aaagcaagta aaacctctac aaatgtggta aaatccgata agggactaga gcatggctac     5040

gtagataagt agcatggcgg gttaatcatt aactacaagg aacccctagt gatggagttg     5100

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga     5160

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgccagct ggcgtaatag     5220

cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatggcg     5280

attccagacg attgagcgtc aaaatgtagg tatttccatg agcgtttttc cgttgcaatg     5340

gctggcggta atattgttct ggatattacc agcaaggccg atagtttgag ttcttctact     5400

caggcaagtg atgttattac taatcaaaga agtattgcga caacggttaa tttgcgtgat     5460

ggacagactc ttttactcgg tggcctcact gattataaaa acacttctca ggattctggc     5520

gtaccgttcc tgtctaaaat ccctttaatc ggcctcctgt ttagctcccg ctctgattct     5580

aacgaggaaa gcacgttata cgtgctcgtc aaagcaacca tagtacgcgc cctgtagcgg     5640

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc     5700

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc     5760

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct     5820

cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac     5880

ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac     5940

tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat     6000

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa     6060

aatattaacg tctacaattt aaatatttgc ttatacaatc ttcctgtttt tggggctttt     6120

ctgattatca accggggtac atatgattga catgctagtt ttacgattac cgttcatcga     6180

ttctcttgtt tgctccagac tctcaggcaa tgacctgata gcctttgtag agacctctca     6240

aaaatagcta ccctctccgg catgaattta tcagctagaa cggttgaata tcatattgat     6300

ggtgatttga ctgtctccgg cctttctcac ccgtttgaat ctttacctac acattactca     6360

ggcattgcat ttaaaatata tgagggttct aaaaattttt atccttgcgt tgaaataaag     6420

gcttctcccg caaaagtatt acagggtcat aatgtttttg gtacaaccga tttagcttta     6480

tgctctgagg ctttattgct taattttgct aattctttgc cttgcctgta tgatttattg     6540

gatgttggaa tcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc     6600

gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac     6660

acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca     6720

gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg tcatcaccga     6780

aacgcgcgag acgaaagggc ctcgtgatac gcctattttt ataggttaat gtcatgataa     6840

taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt     6900

gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa     6960

tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta     7020

ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag     7080

taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca     7140

gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta     7200

aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc     7260

gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc     7320

ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca     7380

ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc     7440

acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca     7500

taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac     7560

tattaactgg cgaactactt actctagctt cccggcaaca attaatagac tggatggagg     7620

cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg     7680

ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg     7740

gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac     7800

gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc     7860

aagtttactc atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct     7920

aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc     7980

actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc     8040

gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg     8100

atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa     8160

atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc     8220

ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt     8280

gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa     8340

cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc     8400

tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc     8460

cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct     8520

ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat     8580

gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc     8640

tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg     8700

ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc     8760

gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg     8820

cgcgttggcc gattcattaa tgcagcagct gcgcgctcgc tcgctcactg aggccgcccg     8880

ggcaaagccc gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg     8940

cagagaggga gtggccaact ccatcactag gggttccttg tagttaatga ttaacccgcc     9000

atgctactta tctacgtagc catgct                                          9026


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  9
ggattacaag gatgacgacg a                                                 21


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  10
tccagagtcc cagcatcttc                                                   20


<210>  11
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  11
ttcgacctcg agatggatta caaggatgac gacgataagc ctggtgtgac tgttctcaa        59


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  12
ttcgacggat ccctggtcac tgaggaactc                                        30


<210>  13
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  13
aaaaaaacgc gtctcagtcc attaggagcc agtagc                                 36


<210>  14
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  14
cccccccaag cttctgccga cagatcctgg aggcg                                  35


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  15
ctcagtccat taggagccag t                                                 21


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  16
aaggcaacct ccaagacact                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  17
ggattacaag gatgacgacg a                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  18
tccagagtcc cagcatcttc                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  19
cctggtgtga ctgttctcaa                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  20
tccagagtcc cagcatcttc                                                   20


<210>  21
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  21
ctcaagctca tggctacact cttctc                                            26


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  22
agagcagaca ctgtttggaa gga                                               23


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  23
gatgcgagcc ctgatgac                                                     18


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  24
gacttgagac actttcttcc                                                   20


<210>  25
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonuleotide probe

<400>  25
ctcactgtcc ataagg                                                       16


<210>  26
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonuleotide probe

<400>  26
ccagcaagag gcca                                                         14


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonuleotide probe

<400>  27
tcggagaacc agcccctgct agctc                                             25


<210>  28
<211>  3895
<212>  DNA
<213>  homo sapiens

<400>  28
atgcctgagc cggggaagaa gccagtctca gcttttagca agaagccacg gtcagtggaa       60

gtggccgcag gcagccctgc cgtgttcgag gccgagacag agcgggcagg agtgaaggtg      120

cgctggcagc gcggaggcag tgacatcagc gccagcaaca agtacggcct ggccacagag      180

ggcacacggc atacgctgac agtgcgggaa gtgggccctg ccgaccaggg atcttacgca      240

gtcattgctg gctcctccaa ggtcaagttc gacctcaagg tcatagaggc agagaaggca      300

gagcccatgc tggcccctgc ccctgcccct gctgaggcca ctggagcccc tggagaagcc      360

ccggccccag ccgctgagct gggagaaagt gccccaagtc ccaaagggtc aagctcagca      420

gctctcaatg gtcctacccc tggagccccc gatgacccca ttggcctctt cgtgatgcgg      480

ccacaggatg gcgaggtgac cgtggaggcc atgggcaccg gagacctgga cctcctatca      540

gccttccgcc gcacgagcct ggctggaggt ggtcggcgga tcagtgatag ccatgaggac      600

actgggattc tggacttcag ctcactgctg aaaaagagag acagtttccg gaccccgagg      660

gactcgaagc tggaggcacc agcagaggag gacgtgtggg agatcctacg gcaggcaccc      720

ccatctgagt acgagcgcat cgccttccag tacggcgtca ctgacctgcg cggcatgcta      780

aagaggctca agggcatgag gcgcgatgag aagaagagca cagcctttca gaagaagctg      840

gagccggcct accaggtgag caaaggccac aagatccggc tgaccgtgga actggctgac      900

catgacgctg aggtcaaatg gctcaagaat ggccaggaga tccagatgag cggcagcaag      960

tacatctttg agtccatcgg tgccaagcgt accctgacca tcagccagtg ctcattggcg     1020

gacgacgcag cctaccagtg cgtggtgggt ggcgagaagt gtagcacgga gctctttgtg     1080

aaagagcccc ctgtgctcat cacgcgcccc ttggaggacc agctggtgat ggtggggcag     1140

cgggtggagt ttgagtgtga agtatcggag gagggggcgc aagtcaaatg gctgaaggac     1200

ggggtggagc tgacccggga ggagaccttc aaataccggt tcaagaagga cgggcagaga     1260

caccacctga tcatcaacga ggccatgctg gaggacgcgg ggcactatgc actgtgcact     1320

agcgggggcc aggcgctggc tgagctcatt gtgcaggaaa agaagctgga ggtgtaccag     1380

agcatcgcag acctgatggt gggcgcaaag gaccaggcgg tgttcaaatg tgaggtctca     1440

gatgagaatg ttcggggtgt gtggctgaag aatgggaagg agctggtgcc cgacagccgc     1500

ataaaggtgt cccacatcgg gcgggtccac aaactgacca ttgacgacgt cacacctgcc     1560

gacgaggctg actacagctt tgtgcccgag ggcttcgcct gcaacctgtc agccaagctc     1620

cacttcatgg aggtcaagat tgacttcgta cccaggcagg aacctcccaa gatccacctg     1680

gactgcccag gccgcatacc agacaccatt gtggttgtag ctggaaataa gctacgtctg     1740

gacgtcccta tctctgggga ccctgctccc actgtgatct ggcagaaggc tatcacgcag     1800

gggaataagg ccccagccag gccagcccca gatgccccag aggacacagg tgacagcgat     1860

gagtgggtgt ttgacaagaa gctgctgtgt gagaccgagg gccgggtccg cgtggagacc     1920

accaaggacc gcagcatctt cacggtcgag ggggcagaga aggaagatga gggcgtctac     1980

acggtcacag tgaagaaccc tgtgggcgag gaccaggtca acctcacagt caaggtcatc     2040

gacgtgccag acgcacctgc ggcccccaag atcagcaacg tgggagagga ctcctgcaca     2100

gtacagtggg agccgcctgc ctacgatggc gggcagccca tcctgggcta catcctggag     2160

cgcaagaaga agaagagcta ccggtggatg cggctgaact tcgacctgat tcaggagctg     2220

agtcatgaag cgcggcgcat gatcgagggc gtggtgtacg agatgcgcgt ctacgcggtc     2280

aacgccatcg gcatgtccag gcccagccct gcctcccagc ccttcatgcc tatcggtccc     2340

cccagcgaac ccacccacct ggcagtagag gacgtctctg acaccacggt ctccctcaag     2400

tggcggcccc cagagcgcgt gggagcagga ggcctggatg gctacagcgt ggagtactgc     2460

ccagagggct gctcagagtg ggtggctgcc ctgcaggggc tgacagagca cacatcgata     2520

ctggtgaagg acctgcccac gggggcccgg ctgcttttcc gagtgcgggc acacaatatg     2580

gcagggcctg gagcccctgt taccaccacg gagccggtga cagtgcagga gatcctgcaa     2640

cggccacggc ttcagctgcc caggcacctg cgccagacca ttcagaagaa ggtcggggag     2700

cctgtgaacc ttctcatccc tttccagggc aagccccggc ctcaggtgac ctggaccaaa     2760

gaggggcagc ccctggcagg cgaggaggtg agcatccgca acagccccac agacaccatc     2820

ctgttcatcc gggccgctcg ccgcgtgcat tcaggcactt accaggtgac ggtgcgcatt     2880

gagaacatgg aggacaaggc cacgctggtg ctgcaggttg ttgacaagcc aagtcctccc     2940

caggatctcc gggtgactga cgcctggggt cttaatgtgg ctctggagtg gaagccaccc     3000

caggatgtcg gcaacacgga gctctggggg tacacagtgc agaaagccga caagaagacc     3060

atggagtggt tcaccgtctt ggagcattac cgccgcaccc actgcgtggt gccagagctc     3120

atcattggca atggctacta cttccgcgtc ttcagccaga atatggttgg ctttagtgac     3180

agagcggcca ccaccaagga gcccgtcttt atccccagac caggcatcac ctatgagcca     3240

cccaactata aggccctgga cttctccgag gccccaagct tcacccagcc cctggtgaac     3300

cgctcggtca tcgcgggcta cactgctatg ctctgctgtg ctgtccgggg tagccccaag     3360

cccaagattt cctggttcaa gaatggcctg gacctgggag aagacgcccg cttccgcatg     3420

ttcagcaagc agggagtgtt gactctggag attagaaagc cctgcccctt tgacgggggc     3480

atctatgtct gcagggccac caacttacag ggcgaggcac ggtgtgagtg ccgcctggag     3540

gtgcgagtgc ctcagtgacc aggctggctc ctggggatgg ccaggtacaa ccggatgcca     3600

gccccgtgcc aggagcctgg agggaagttg gggaaacccc tccctactgt tggatgtatg     3660

tgtgacaagt gtgtctcctg tgctgcgatg ggggatcagc agggcagttg tcgggcagtc     3720

ctgagtgggt gttgcacaga ctggtccaca gggctcctga aggaagcccc tggatctttg     3780

gggtaaaagg agggtggcct caagaaacaa tgtctgggga caggcctttc tggcctgcta     3840

tgtcttccca atgtttattg ggcaataaaa gataagtgca gtcacagaga actca          3895


<210>  29
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  DNA sequence encoding Myc

<400>  29
gagcaaaagc ttattagcga ggaagatctg                                        30


<210>  30
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  Myc-tag protein sequence

<400>  30

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  31
<211>  576
<212>  DNA
<213>  Human cytomegalovirus

<400>  31
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa       60

cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata      120

atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag      180

tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc      240

cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta      300

tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg      360

cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt      420

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca      480

aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt acggtgggag      540

gtctatataa gcagagctgg tttagtgaac cgtcag                                576


<210>  32
<211>  1285
<212>  PRT
<213>  artificial

<220>
<223>  Myc-tagged human cMyBP-C protein

<400>  32

Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Pro Glu Pro 
1               5                   10                  15      


Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro Arg Ser Val Glu 
            20                  25                  30          


Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu Thr Glu Arg Ala 
        35                  40                  45              


Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp Ile Ser Ala Ser 
    50                  55                  60                  


Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His Thr Leu Thr Val 
65                  70                  75                  80  


Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala Val Ile Ala Gly 
                85                  90                  95      


Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu Ala Glu Lys Ala 
            100                 105                 110         


Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu Ala Thr Gly Ala 
        115                 120                 125             


Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly Glu Ser Ala Pro 
    130                 135                 140                 


Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly Pro Thr Pro Gly 
145                 150                 155                 160 


Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg Pro Gln Asp Gly 
                165                 170                 175     


Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala Arg Val Ala Gly 
            180                 185                 190         


Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe Lys Gly Lys Trp 
        195                 200                 205             


Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln Leu His Asp Ser 
    210                 215                 220                 


Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu His Ile Thr Asp 
225                 230                 235                 240 


Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu Val Ser Thr Lys 
                245                 250                 255     


Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val His Glu Ala Met 
            260                 265                 270         


Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg Arg Thr Ser Leu 
        275                 280                 285             


Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu Asp Thr Gly Ile 
    290                 295                 300                 


Leu Asp Phe Ser Ser Leu Leu Lys Lys Ser Ser Ser Phe Arg Thr Pro 
305                 310                 315                 320 


Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp Val Trp Glu Ile 
                325                 330                 335     


Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile Ala Phe Gln Tyr 
            340                 345                 350         


Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu Lys Gly Met Arg 
        355                 360                 365             


Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys Leu Glu Pro Ala 
    370                 375                 380                 


Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr Val Glu Leu Ala 
385                 390                 395                 400 


Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly Gln Glu Ile Gln 
                405                 410                 415     


Met Ser Gly Arg Tyr Ile Phe Glu Ser Ile Gly Ala Lys Arg Thr Leu 
            420                 425                 430         


Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala Ala Tyr Gln Cys Val 
        435                 440                 445             


Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe Val Lys Glu Pro Pro 
    450                 455                 460                 


Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu Val Met Val Gly Gln 
465                 470                 475                 480 


Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu Gly Ala Gln Val Lys 
                485                 490                 495     


Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu Glu Thr Phe Lys Tyr 
            500                 505                 510         


Arg Phe Lys Lys Asp Gly Gln Arg His His Leu Ile Ile Asn Glu Ala 
        515                 520                 525             


Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys Thr Ser Gly Gly Gln 
    530                 535                 540                 


Ala Leu Ala Glu Leu Ile Val Gln Glu Lys Lys Leu Glu Val Tyr Gln 
545                 550                 555                 560 


Ser Ile Ala Asp Leu Met Val Gly Ala Lys Asp Gln Ala Val Phe Lys 
                565                 570                 575     


Cys Glu Val Ser Asp Glu Asn Val Arg Gly Val Trp Leu Lys Asn Gly 
            580                 585                 590         


Lys Glu Leu Val Pro Asp Ser Arg Ile Lys Val Ser His Ile Gly Arg 
        595                 600                 605             


Val His Lys Leu Thr Ile Asp Asp Val Thr Pro Ala Asp Glu Ala Asp 
    610                 615                 620                 


Tyr Ser Phe Val Pro Glu Gly Phe Ala Cys Asn Leu Ser Ala Lys Leu 
625                 630                 635                 640 


His Phe Met Glu Val Lys Ile Asp Phe Val Pro Arg Gln Glu Pro Pro 
                645                 650                 655     


Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro Asp Thr Ile Val Val 
            660                 665                 670         


Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro Ile Ser Gly Asp Pro 
        675                 680                 685             


Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr Gln Gly Asn Lys Ala 
    690                 695                 700                 


Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp Thr Gly Asp Ser Asp 
705                 710                 715                 720 


Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu Thr Glu Gly Arg Val 
                725                 730                 735     


Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe Thr Val Glu Gly Ala 
            740                 745                 750         


Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr Val Lys Asn Pro Val 
        755                 760                 765             


Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val Ile Asp Val Pro Asp 
    770                 775                 780                 


Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp Ser Cys Thr 
785                 790                 795                 800 


Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro Ile Leu Gly 
                805                 810                 815     


Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp Met Arg Leu 
            820                 825                 830         


Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu Ala Arg Arg Met Ile 
        835                 840                 845             


Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala Val Asn Ala Ile Gly 
    850                 855                 860                 


Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro Ile Gly Pro 
865                 870                 875                 880 


Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr Thr 
                885                 890                 895     


Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly Leu 
            900                 905                 910         


Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys Ser Glu Trp Val 
        915                 920                 925             


Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile Leu Val Lys Asp 
    930                 935                 940                 


Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn Met 
945                 950                 955                 960 


Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro Val Thr Val Gln 
                965                 970                 975     


Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln 
            980                 985                 990         


Thr Ile Gln Lys Lys Val Gly Glu  Pro Val Asn Leu Leu  Ile Pro Phe 
        995                 1000                 1005             


Gln Gly  Lys Pro Arg Pro Gln  Val Thr Trp Thr Lys  Glu Gly Gln 
    1010                 1015                 1020             


Pro Leu  Ala Gly Glu Glu Val  Ser Ile Arg Asn Ser  Pro Thr Asp 
    1025                 1030                 1035             


Thr Ile  Leu Phe Ile Arg Ala  Ala Arg Arg Val His  Ser Gly Thr 
    1040                 1045                 1050             


Tyr Gln  Val Thr Val Arg Ile  Glu Asn Met Glu Asp  Lys Ala Thr 
    1055                 1060                 1065             


Leu Val  Leu Gln Val Val Asp  Lys Pro Ser Pro Pro  Gln Asp Leu 
    1070                 1075                 1080             


Arg Val  Thr Asp Ala Trp Gly  Leu Asn Val Ala Leu  Glu Trp Lys 
    1085                 1090                 1095             


Pro Pro  Gln Asp Val Gly Asn  Thr Glu Leu Trp Gly  Tyr Thr Val 
    1100                 1105                 1110             


Gln Lys  Ala Asp Lys Lys Thr  Met Glu Trp Phe Thr  Val Leu Glu 
    1115                 1120                 1125             


His Tyr  Arg Arg Thr His Cys  Val Val Pro Glu Leu  Ile Ile Gly 
    1130                 1135                 1140             


Asn Gly  Tyr Tyr Phe Arg Val  Phe Ser Gln Asn Met  Val Gly Phe 
    1145                 1150                 1155             


Ser Asp  Arg Ala Ala Thr Thr  Lys Glu Pro Val Phe  Ile Pro Arg 
    1160                 1165                 1170             


Pro Gly  Ile Thr Tyr Glu Pro  Pro Asn Tyr Lys Ala  Leu Asp Phe 
    1175                 1180                 1185             


Ser Glu  Ala Pro Ser Phe Thr  Gln Pro Leu Val Asn  Arg Ser Val 
    1190                 1195                 1200             


Ile Ala  Gly Tyr Thr Ala Met  Leu Cys Cys Ala Val  Arg Gly Ser 
    1205                 1210                 1215             


Pro Lys  Pro Lys Ile Ser Trp  Phe Lys Asn Gly Leu  Asp Leu Gly 
    1220                 1225                 1230             


Glu Asp  Ala Arg Phe Arg Met  Phe Ser Lys Gln Gly  Val Leu Thr 
    1235                 1240                 1245             


Leu Glu  Ile Arg Lys Pro Cys  Pro Phe Asp Gly Gly  Ile Tyr Val 
    1250                 1255                 1260             


Cys Arg  Ala Thr Asn Leu Gln  Gly Glu Ala Arg Cys  Glu Cys Arg 
    1265                 1270                 1275             


Leu Glu  Val Arg Val Pro Gln  
    1280                 1285 


<210>  33
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Forward primer for exogenous MYBPC3 (in myc sequence)

<400>  33
gcaaaagctt attagcgagg aa                                                22


<210>  34
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Reverse primer for exogenous MYBPC3 (in exon 2)

<400>  34
caggccgtac ttgttgctg                                                    19


<210>  35
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Forward primer for total MYBPC3 (in exon 1)

<400>  35
ggggaagaag ccagtctcag                                                   20


