                         SEQUENCE LISTING

<110>  DNA Therapeutics et al
 
<120>  INHIBITION OF DNA DAMAGE REPAIR BY ARTIFICIAL ACTIVATION OF PARP 
       WITH OLIGONUCLEOTIDE MOLECULES

<130>  B1590EP

<160>  17    

<170>  PatentIn version 3.3

<210>  1
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait12


<220>
<221>  stem_loop
<222>  (1)..(12)

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  nucelotides 6 and 7 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (13)..(24)

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  nucelotides 18 and 19 are linked by an hexaethyleneglycol linker

<400>  1
aagcacgtgc ttggagcatg ctcc                                            24


<210>  2
<211>  40
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait20


<220>
<221>  stem_loop
<222>  (1)..(20)

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  nucelotides 10 and 11 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (21)..(40)

<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  nucelotides 30 and 31 are linked by an hexaethyleneglycol linker

<400>  2
aagcactgca tgcagtgctt ggagcatgac gtcatgctcc                           40


<210>  3
<211>  62
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait30


<220>
<221>  stem_loop
<222>  (1)..(30)

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  nucelotides 15 and 16 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (33)..(62)

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  nucelotides 47 and 48 are linked by an hexaethyleneglycol linker

<400>  3
accagtagct ctggtaccag agctactggt taagggctga caggccatgg cctgtcagcc     60

ct                                                                    62


<210>  4
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait32


<220>
<221>  stem_loop
<222>  (1)..(32)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  nucelotides 16 and 17 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (33)..(64)

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  nucelotides 48 and 49 are linked by an hexaethyleneglycol linker

<400>  4
aaccagtagc tctggtacca gagctactgg ttaagggctg acaggccatg gcctgtcagc     60

cctt                                                                  64


<210>  5
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait32s


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  phosphorothioate backbone

<220>
<221>  stem_loop
<222>  (1)..(32)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  nucelotides 16 and 17 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (33)..(64)

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  nucelotides 48 and 49 are linked by an hexaethyleneglycol linker

<220>
<221>  modified_base
<222>  (62)..(64)
<223>  phosphorothioate backbone

<400>  5
gcacagtggc tctgatatca gagccactgt gcccagactg acatgactag tcatgtcagt     60

ctgg                                                                  64


<210>  6
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait32b


<220>
<221>  stem_loop
<222>  (1)..(32)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  nucelotides 16 and 17 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (33)..(64)

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  nucelotides 48 and 49 are linked by an hexaethyleneglycol linker

<400>  6
gcacagtggc tctgatatca gagccactgt gcccagactg acatgactag tcatgtcagt     60

ctgg                                                                  64


<210>  7
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait32L


<220>
<221>  stem_loop
<222>  (1)..(32)

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  nucelotides 16 and 17 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (33)..(64)

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  nucelotides 48 and 49 are linked by an hexaethyleneglycol linker

<400>  7
aagcactgca cacagcgctg tgtgcagtgc ttggagcatg accctagatc tagggtcatg     60

ctcc                                                                  64


<210>  8
<211>  16
<212>  DNA
<213>  artificial sequence

<220>
<223>  Dbait8H


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  mod_base=phosphorothioate backbone

<220>
<221>  stem_loop
<222>  (1)..(16)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  nucelotides 8 and 9 are linked by an hexaethyleneglycol linker

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  mod_base=phosphorothioate backbone

<400>  8
gctaggtcga cctagc                                                     16


<210>  9
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  Dbait32Hc


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  phosporothioate backbone

<220>
<221>  modified_base
<222>  (32)..(33)
<223>  nucelotides 32 and 33 are linked by an hexaethyleneglycol linker

<220>
<221>  modified_base
<222>  (62)..(64)
<223>  phosporothioate backbone

<400>  9
gctgtgccca caacccagca aacaagccta gatctaggct tgtttgctgg gttgtgggca     60

cagc                                                                  64


<210>  10
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  Bait32C


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  loop=hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (1)..(32)

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  loop=hexaethyleneglycol linker

<400>  10
tggtctcgat gaccaattcc cgactgtccg gt                                   32


<210>  11
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait14


<220>
<221>  stem_loop
<222>  (1)..(14)

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  nucelotides 7 and 8 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (17)..(30)

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  nucelotides 23 and 24 are linked by an hexaethyleneglycol linker

<400>  11
accagtatac tggttaaggg ctgcagccct                                      30


<210>  12
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait15sd3


<220>
<221>  stem_loop
<222>  (1)..(16)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  nucelotides 8 and 9 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (18)..(31)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  nucelotides 24 and 25 are linked by an hexaethyleneglycol linker

<220>
<221>  modified_base
<222>  (31)..(31)
<223>  dideoxynucleotide with phosphorothioate backbone

<400>  12
aagcactgca gtgcttggag catgcatgct c                                    31


<210>  13
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait16


<220>
<221>  stem_loop
<222>  (1)..(16)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  nucelotides 8 and 9 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (17)..(32)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  nucelotides 24 and 25 are linked by an hexaethyleneglycol linker

<400>  13
aaccagtata ctggttaagg gctgcagccc tt                                   32


<210>  14
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait16S


<220>
<221>  stem_loop
<222>  (1)..(16)

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  nucelotides 8 and 9 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (17)..(32)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  nucelotides 24 and 25 are linked by an hexaethyleneglycol linker

<220>
<221>  modified_base
<222>  (30)..(32)
<223>  phosphorothioate backbone

<400>  14
gcacagtgca ctgtgcccag actgcagtct gg                                   32


<210>  15
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait16s3


<220>
<221>  stem_loop
<222>  (1)..(16)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  nucelotides 8 and 9 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (17)..(32)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  nucelotides 24 and 25 are linked by an hexaethyleneglycol linker

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  phosphorothioate backbone

<400>  15
aagcactgca gtgcttggag catgcatgct cc                                   32


<210>  16
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait16sd3


<220>
<221>  stem_loop
<222>  (1)..(16)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  nucelotides 8 and 9 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (17)..(32)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  nucelotides 24 and 25 are linked by an hexaethyleneglycol linker

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  dideoxynucleotide with phosphorothioate backbone

<400>  16
aagcactgca gtgcttggag catgcatgct cc                                   32


<210>  17
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  Pbait16p5


<220>
<221>  stem_loop
<222>  (1)..(16)

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  nucelotides 8 and 9 are linked by an hexaethyleneglycol linker

<220>
<221>  stem_loop
<222>  (17)..(32)

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  nucelotides 24 and 25 are linked by an hexaethyleneglycol linker

<220>
<221>  modified_base
<222>  (32)..(32)
<223>  modification of the 3'end by adding a 5'phosphate

<400>  17
aagcactgca gtgcttggag catgcatgct cc                                   32


