               SEQUENCE LISTING

<110> MorphoSys AG

<120> Antibodies Targeting Specifically Human CXCR2

<160> 297

<170> BiSSAP 1.2

<210> 1
<211> 360
<212> PRT
<213> Homo sapiens

<220> 
<223> human CXCR2

<400> 1
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      
Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          
Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              
Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  
Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  
Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      
Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         
Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             
Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 
Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 
Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     
Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         
Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             
Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 
Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 
Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     
Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         
Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             
Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 
Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 
Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     
Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         
Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 

<210> 2
<211> 48
<212> PRT
<213> Homo sapiens

<220> 
<223> CXCR2 N-terminus

<400> 2
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      
Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          
Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              



<210> 3
<211> 21
<212> PRT
<213> Homo sapiens

<220> 
<223> CXCR2 extracellular domain 3

<400> 3
Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg Arg 
1               5                   10                  15      
Asn His Ile Asp Arg 
            20      

<210> 4
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> CXCR2 N-terminal portion

<400> 4
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      
Gly 
    

<210> 5
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 5
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      
Gly Cys 
        

<210> 6
<211> 49
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 6
Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      
Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          
Leu Leu Asp Ala Ala Pro Ser Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              
Cys 
    

<210> 7
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 7
Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Ser Glu Arg 
1               5                   10                  15      
Arg Asn His Ile Asp Arg Ala Cys 
            20                  

<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 8
Ser Tyr Ala Ile Ser 
1               5   

<210> 9
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 9
Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 10
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 10
Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr 
1               5                   10              

<210> 11
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 11
Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser Ser Val Asn 
1               5                   10              

<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 12
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 13
Gly Ala Thr Asp Phe Ser Ala Asn Gln Val Val 
1               5                   10      

<210> 14
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 14
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Gly Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser 
            20                  25                  30          
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Thr Asp Phe Ser Ala 
                85                  90                  95      
Asn Gln Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 15
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 15
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210> 16
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 16
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgggaccatt      60

agctgtagcg gcagcagcag caacattggt tcttcttctg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgcggt gctactgact tctctgctaa ccaggttgtg     300

tttggcggcg gcacgaagtt aaccgttctt ggccag                               336


<210> 17
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..366
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 17
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct tcttacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcgttggcga agcgaaatac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgactct     300

tctggttacg acggttacta cgctttcgct tactggggcc aaggcaccca ggtgactgtt     360

agctca                                                                366


<210> 18
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 18
Arg Tyr Ala Met His 
1               5   

<210> 19
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 19
Val Ile Asn Pro Tyr Asn Gly Asn Thr Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 20
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 20
Gly Ser His Ile Gln Ala Gly Ala Phe Asp Tyr 
1               5                   10      

<210> 21
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 21
Arg Ala Ser Gln Gly Ile Asn Asn Arg Leu Asn 
1               5                   10      

<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 22
Asp Gly Ser Ser Leu Gln Ser 
1               5           

<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 23
Gln Gln Tyr Ile His Phe Pro Val Thr 
1               5                   

<210> 24
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 24
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asn Arg 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile His Phe Pro Val 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 

<210> 25
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Val Ile Asn Pro Tyr Asn Gly Asn Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Ser His Ile Gln Ala Gly Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 26
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..327
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 26
gatatccaga tgacccagag cccgagcagc ctgagcgcca gcgtgggcga tcgcgtgacc      60

attacctgca gagccagcca gggtattaac aaccgtctga actggtacca gcagaaaccg     120

ggcaaagcgc cgaaactatt aatctacgac ggttcttctc tgcaaagcgg cgtgccgagc     180

cgctttagcg gcagcggatc cggcaccgat ttcaccctga ccattagctc tctgcaaccg     240

gaagactttg cgacctatta ttgccagcag tacatccatt tcccggttac ctttggccag     300

ggcacgaaag ttgaaattaa acgtacg                                         327


<210> 27
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..360
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 27
caggtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggtgccag cgtgaaagtt      60

agctgcaaag cgtccggata taccttctct cgttacgcta tgcattgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcgtt atcaacccgt acaacggcaa cacgcgttac     180

gcgcagaaat ttcagggccg ggtgaccatg acccgtgata ccagcattag caccgcgtat     240

atggaactga gccgtctgcg tagcgaagat acggccgtgt attattgcgc gcgtggttct     300

catatccagg ctggtgcttt cgattactgg ggccaaggca ccctggtgac tgttagctca     360


<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 28
Ser Tyr Trp Met Ser 
1               5   

<210> 29
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 29
Val Ile Ser Tyr Ser Gly Ser Glu Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 30
Gly Arg Val Gly Tyr Ala Phe Asp Tyr 
1               5                   

<210> 31
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 31
Ser Gly Ser Ser Ser Asn Ile Gly Val Asn Tyr Val Asn 
1               5                   10              

<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 32
Ser Asn Asn Gln Arg Pro Ser 
1               5           

<210> 33
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 33
Gln Ser Arg Ala Ser Gly Phe Tyr Ser Val Val 
1               5                   10      

<210> 34
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 34
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Val Asn 
            20                  25                  30          
Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Arg Ala Ser Gly Phe 
                85                  90                  95      
Tyr Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 35
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 35
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Tyr Ser Gly Ser Glu Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Val Gly Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 36
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 36
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt gttaactacg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac tctaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgccag tctcgtgctt ctggtttcta ctctgttgtg     300

tttggcggcg gcacgaagtt aaccgttctt ggccag                               336


<210> 37
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 37
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tcttactgga tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttact ctggttctga aaccttctat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtcgt     300

gttggttacg ctttcgatta ctggggccaa ggcaccctgg tgactgttag ctca           354


<210> 38
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 38
Ser Asn Gly Met Ser 
1               5   

<210> 39
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 39
Ala Ile Ser Ser Ser Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 40
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 40
Gly Tyr Gly Phe Asp Val 
1               5       

<210> 41
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 41
Ser Gly Ser Ser Ser Asn Ile Gly Val Asn Ile Val Asn 
1               5                   10              

<210> 42
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 42
Ser Thr Ser Asn Arg Pro Ser 
1               5           

<210> 43
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 43
Ala Thr Arg Asp Gly Ile Ser Lys Ser Val Val 
1               5                   10      

<210> 44
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 44
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Val Asn 
            20                  25                  30          
Ile Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Arg Asp Gly Ile Ser 
                85                  90                  95      
Lys Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 45
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 45
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Ser Ser Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Tyr Gly Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 46
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 46
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt gttaacatcg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac tctacttcta accgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ctactgcgct actcgtgacg gtatctctaa atctgttgtg     300

tttggcggcg gcacgaagtt aaccgttctt ggccag                               336


<210> 47
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..345
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 47
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tctaacggta tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgct atctcttctt ctggttctaa aacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggttac     300

ggtttcgacg tttggggcca aggcaccctg gtgactgtta gctca                     345


<210> 48
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 48
Ser Asn Ala Met Ser 
1               5   

<210> 49
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 49
Phe Ile Ser Tyr Ser Gly Ser His Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 50
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 50
Tyr Thr Arg Phe Leu Ser Arg Pro Ala Phe Asp Pro 
1               5                   10          

<210> 51
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 51
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 52
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 52
Tyr Asn Ser Lys Arg Pro Ser 
1               5           

<210> 53
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 53
Gly Ala Tyr Asp Arg Lys Met Asn Ser Tyr Val 
1               5                   10      

<210> 54
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 54
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Tyr Asn Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Tyr Asp Arg Lys 
                85                  90                  95      
Met Asn Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         
Gln 
    

<210> 55
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 55
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Asn 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Phe Ile Ser Tyr Ser Gly Ser His Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Thr Arg Phe Leu Ser Arg Pro Ala Phe Asp Pro Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 56
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..339
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 56
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtaccg gcagcagcag caacattggt gctggttacg acgtgcattg gtaccagcag     120

ctgccgggca cggcgccgaa actgctgatc tactacaact ctaaacgccc gagcggcgtg     180

ccggatcgct ttagcggatc caaaagcggc accagcgcca gcctggcgat taccggcctg     240

caagcagaag acgaagcgga ttattactgc ggtgcttacg accgtaaaat gaactcttac     300

gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                            339


<210> 57
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..363
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 57
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt cacctttaac tctaacgcta tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccttc atctcttact ctggttctca tacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgttacact     300

cgtttcctgt ctcgtccggc tttcgatccg tggggccaag gcaccctggt gactgttagc     360

tca                                                                   363


<210> 58
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 58
Ser Tyr Thr Met Ser 
1               5   

<210> 59
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 59
Ala Ile His Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 60
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 60
Val Pro Ala Tyr Tyr Gly Phe Asp His 
1               5                   

<210> 61
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 61
Ser Gly Asp Ser Leu Gly Ala Phe Tyr Val His 
1               5                   10      

<210> 62
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 62
Arg Thr Asn Asn Arg Pro Ser 
1               5           

<210> 63
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 63
Ala Ser Tyr Ala Ser Arg Asn Arg Val 
1               5                   

<210> 64
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 64
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Ser Leu Gly Ala Phe Tyr Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Arg Thr Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Ala Ser Arg Asn Arg Val 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105             

<210> 65
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 65
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile His Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Pro Ala Tyr Tyr Gly Phe Asp His Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 66
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..324
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 66
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgattctct gggtgctttc tacgttcatt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctaccgtact aacaaccgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg cgcttcttac gcttctcgta accgtgtgtt tggcggcggc     300

acgaagttaa ccgttcttgg ccag                                            324


<210> 67
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 67
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tcttacacta tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgct atccattctt ctggttcttc tacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgttccg     300

gcttactacg gtttcgatca ttggggccaa ggcaccctgg tgactgttag ctca           354


<210> 68
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 68
Ser Tyr Ala Ile Ser 
1               5   

<210> 69
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 69
Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 70
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 70
Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr 
1               5                   10              

<210> 71
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 71
Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser Ser Val Asn 
1               5                   10              

<210> 72
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 72
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 73
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 73
Gly Ser Thr Asp Met Ser Thr Asn Ser Ile Val 
1               5                   10      

<210> 74
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 74
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Gly Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser 
            20                  25                  30          
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Thr Asp Met Ser Thr 
                85                  90                  95      
Asn Ser Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 75
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 75
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210> 76
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 76
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgggaccatt      60

agctgtagcg gcagcagcag caacattggt tcttcttctg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgcggt tctactgaca tgtctactaa ctctatcgtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 77
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..366
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 77
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct tcttacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcgttggcga agcgaaatac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgactct     300

tctggttacg acggttacta cgctttcgct tactggggcc aaggcaccca ggtgactgtt     360

agctca                                                                366


<210> 78
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 78
Ser Tyr Ala Ile Ser 
1               5   

<210> 79
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 79
Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 80
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 80
Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr 
1               5                   10              

<210> 81
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 81
Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser Ser Val Asn 
1               5                   10              

<210> 82
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 82
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 83
Ala Thr Ala Asp Gln Arg Gly Ile Val 
1               5                   

<210> 84
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 84
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Gly Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser 
            20                  25                  30          
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Ala Asp Gln Arg Gly 
                85                  90                  95      
Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110 

<210> 85
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 85
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210> 86
<211> 330
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..330
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 86
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgggaccatt      60

agctgtagcg gcagcagcag caacattggt tcttcttctg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgcgct actgctgacc agcgtggtat cgtgtttggc     300

ggcggcacga agttaaccgt cctaggtcag                                      330


<210> 87
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..366
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 87
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct tcttacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcgttggcga agcgaaatac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgactct     300

tctggttacg acggttacta cgctttcgct tactggggcc aaggcaccca ggtgactgtt     360

agctca                                                                366


<210> 88
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 88
Ser Tyr Ala Ile Ser 
1               5   

<210> 89
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 89
Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 90
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 90
Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr 
1               5                   10              

<210> 91
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 91
Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser Ser Val Asn 
1               5                   10              

<210> 92
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 92
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 93
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 93
Ala Val Thr Thr Lys Pro Gln Gly Ile Val 
1               5                   10  

<210> 94
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 94
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Gly Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser 
            20                  25                  30          
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Val Thr Thr Lys Pro Gln 
                85                  90                  95      
Gly Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110     

<210> 95
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 95
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210> 96
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..333
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 96
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgggaccatt      60

agctgtagcg gcagcagcag caacattggt tcttcttctg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgcgct gttactacta aaccgcaggg tatcgtgttt     300

ggcggcggca cgaagttaac cgtcctaggt cag                                  333


<210> 97
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..366
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 97
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct tcttacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcgttggcga agcgaaatac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgactct     300

tctggttacg acggttacta cgctttcgct tactggggcc aaggcaccca ggtgactgtt     360

agctca                                                                366


<210> 98
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 98
Ser Tyr Ala Ile Ser 
1               5   

<210> 99
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 99
Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 100
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 100
Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr 
1               5                   10              

<210> 101
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 101
Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser Ser Val Asn 
1               5                   10              

<210> 102
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 102
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 103
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 103
Ala Ser Thr Asp Ile Ser Arg Val Ile Val 
1               5                   10  

<210> 104
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 104
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Gly Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser 
            20                  25                  30          
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Thr Asp Ile Ser Arg 
                85                  90                  95      
Val Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110     

<210> 105
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 105
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210> 106
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..333
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 106
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgggaccatt      60

agctgtagcg gcagcagcag caacattggt tcttcttctg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgcgct tctactgaca tctctcgtgt tatcgtgttt     300

ggcggcggca cgaagttaac cgtcctaggt cag                                  333


<210> 107
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..366
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 107
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct tcttacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcgttggcga agcgaaatac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgactct     300

tctggttacg acggttacta cgctttcgct tactggggcc aaggcaccca ggtgactgtt     360

agctca                                                                366


<210> 108
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 108
Ser Tyr Ala Ile Ser 
1               5   

<210> 109
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 109
Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 110
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 110
Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr 
1               5                   10              

<210> 111
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 111
Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser Ser Val Asn 
1               5                   10              

<210> 112
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 112
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 113
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 113
Ala Ser Thr Asp Ser Gln Trp Arg Gln Ile Val 
1               5                   10      

<210> 114
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 114
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Gly Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser 
            20                  25                  30          
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Thr Asp Ser Gln Trp 
                85                  90                  95      
Arg Gln Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 115
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 115
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210> 116
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 116
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgggaccatt      60

agctgtagcg gcagcagcag caacattggt tcttcttctg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgcgct tctactgact ctcagtggcg tcagatcgtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 117
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..366
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 117
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct tcttacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcgttggcga agcgaaatac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgactct     300

tctggttacg acggttacta cgctttcgct tactggggcc aaggcaccca ggtgactgtt     360

agctca                                                                366


<210> 118
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 118
Ser Tyr Ala Ile Ser 
1               5   

<210> 119
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 119
Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 120
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 120
Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr 
1               5                   10              

<210> 121
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 121
Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser Ser Val Asn 
1               5                   10              

<210> 122
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 122
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 123
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 123
Ala Ser Arg Asp His Phe Ser His Gly Leu Val 
1               5                   10      

<210> 124
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 124
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Gly Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Ser 
            20                  25                  30          
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Arg Asp His Phe Ser 
                85                  90                  95      
His Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 125
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 125
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Val Gly Glu Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ser Ser Gly Tyr Asp Gly Tyr Tyr Ala Phe Ala Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210> 126
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 126
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgggaccatt      60

agctgtagcg gcagcagcag caacattggt tcttcttctg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgcgct tctcgtgacc atttctctca tggtctggtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 127
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..366
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 127
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgttttct tcttacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcgttggcga agcgaaatac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtgactct     300

tctggttacg acggttacta cgctttcgct tactggggcc aaggcaccca ggtgactgtt     360

agctca                                                                366


<210> 128
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 128
Ser Tyr Trp Met Ser 
1               5   

<210> 129
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 129
Val Ile Ser Tyr Ser Gly Ser Glu Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 130
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 130
Gly Arg Val Gly Tyr Ala Phe Asp Tyr 
1               5                   

<210> 131
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 131
Ser Gly Ser Ser Ser Asn Ile Gly Val Asn Tyr Val Asn 
1               5                   10              

<210> 132
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 132
Ser Asn Asn Gln Arg Pro Ser 
1               5           

<210> 133
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 133
Gln Thr Arg Ala Val His Phe Ala Arg Val Val 
1               5                   10      

<210> 134
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 134
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Val Asn 
            20                  25                  30          
Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Arg Ala Val His Phe 
                85                  90                  95      
Ala Arg Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 135
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 135
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Tyr Ser Gly Ser Glu Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Val Gly Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 136
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 136
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt gtcaactacg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac tctaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgccag actcgtgctg ttcatttcgc tcgtgttgtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 137
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 137
caggtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tcttactgga tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttact ctggttctga aaccttctat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtcgt     300

gttggttacg ctttcgatta ctggggccaa ggcaccctgg tgactgttag ctca           354


<210> 138
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 138
Ser Tyr Ala Met Ser 
1               5   

<210> 139
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 139
Leu Ile Ser Gln Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 140
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 140
Gly Arg Val Gly Tyr Ala Phe Asp Tyr 
1               5                   

<210> 141
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 141
Ser Gly Ser Ser Ser Asn Ile Gly Val Asn Tyr Val Asn 
1               5                   10              

<210> 142
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 142
Ser Asn Asn Gln Arg Pro Ser 
1               5           

<210> 143
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 143
Gln Ser Arg Ala Ser Gly Phe Tyr Ser Val Val 
1               5                   10      

<210> 144
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 144
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Val Asn 
            20                  25                  30          
Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Arg Ala Ser Gly Phe 
                85                  90                  95      
Tyr Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 145
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 145
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Leu Ile Ser Gln Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Arg Val Gly Tyr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 146
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 146
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt gtcaactacg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac tctaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgccag tctcgtgctt ctggtttcta ctctgttgtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 147
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..351
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 147
caggtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt cacctttagc agctacgcca tgagctgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccctg atctctcagg gtggtctgac ttactatgct     180

gatagcgtga aaggccgctt taccatcagc cgcgataatt cgaaaaacac cctgtatctg     240

caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg tggtcgtgtt     300

ggttacgctt tcgattactg gggccaaggc accctggtga ctgttagctc a              351


<210> 148
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 148
Ser Tyr Ala Ile Ser 
1               5   

<210> 149
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 149
His Ile Pro Pro Asn Glu Gly Thr Pro Trp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 150
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 150
Gly Tyr Gly Phe Asp Val 
1               5       

<210> 151
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 151
Ser Gly Ser Ser Ser Asn Ile Gly Val Asn Ile Val Asn 
1               5                   10              

<210> 152
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 152
Ser Thr Ser Asn Arg Pro Ser 
1               5           

<210> 153
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 153
Ala Thr Arg Asp Gly Ile Ser Lys Ser Val Val 
1               5                   10      

<210> 154
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 154
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Val Asn 
            20                  25                  30          
Ile Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Arg Asp Gly Ile Ser 
                85                  90                  95      
Lys Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 155
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 155
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly His Ile Pro Pro Asn Glu Gly Thr Pro Trp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Tyr Gly Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 156
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 156
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt gtcaacatcg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac tctacttcta accgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ctactgcgct actcgtgacg gtatctctaa atctgttgtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 157
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..345
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 157
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgtttagc agctatgcga ttagctgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggccat atcccgccga acgaaggcac tccgtggtac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtggttac     300

ggtttcgacg tttggggcca aggcaccctg gtgactgtta gctca                     345


<210> 158
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 158
Ser Asn Gly Met Ser 
1               5   

<210> 159
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 159
Ser Thr Ser Asn Arg Pro Ser 
1               5           

<210> 160
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 160
Gly Tyr Gly Phe Asp Val 
1               5       

<210> 161
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 161
Ser Gly Ser Ser Ser Asn Ile Gly Val Asn Ile Val Asn 
1               5                   10              

<210> 162
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 162
Leu Leu Ile Tyr Ser Thr Ser Asn Arg Pro Ser 
1               5                   10      

<210> 163
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 163
Arg Tyr Trp Met Ser 
1               5   

<210> 164
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 164
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Val Asn 
            20                  25                  30          
Ile Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Tyr Asp Val Gln Ser 
                85                  90                  95      
His Gln Met Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 165
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 165
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Ser Ser Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Tyr Gly Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 166
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 166
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt gtcaacatcg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac tctacttcta accgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgcggt acttacgacg ttcagtctca tcagatggtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 167
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..345
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 167
caggtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tctaacggta tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgct atctcttctt ctggttctaa aacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggttac     300

ggtttcgacg tttggggcca aggcaccctg gtgactgtta gctca                     345


<210> 168
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 168
Gly Phe Thr Phe Ser Arg Tyr Trp Met Ser 
1               5                   10  

<210> 169
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 169
Val Ile Ser Tyr Ser Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 170
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 170
Gly Arg Ala Tyr Gly Tyr Phe Asp Pro 
1               5                   

<210> 171
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 171
Ser Gly Ser Ser Ser Asn Ile Gly Lys Lys Thr Val Ser 
1               5                   10              

<210> 172
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 172
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 173
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 173
Gln Ser Thr Asp Ser Thr Thr Glu Ile Val 
1               5                   10  

<210> 174
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 174
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Lys 
            20                  25                  30          
Thr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Asp Ser Thr Thr 
                85                  90                  95      
Glu Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110     

<210> 175
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 175
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Tyr Ser Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Ala Tyr Gly Tyr Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 176
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..333
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 176
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt aaaaaaactg tgtcttggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgccag tctactgact ctactactga aatcgtgttt     300

ggcggcggca cgaagttaac cgtcctaggt cag                                  333


<210> 177
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 177
caggtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct cgttactgga tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttact ctggttctga aacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtcgt     300

gcttacggtt acttcgatcc gtggggccaa ggcaccctgg tgactgttag ctca           354


<210> 178
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 178
Asn Tyr Trp Ile Ala 
1               5   

<210> 179
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 179
Ile Ile Asp Pro Ser Asn Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 180
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 180
Gly Arg Tyr Tyr Gly Phe Phe Asp Tyr 
1               5                   

<210> 181
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 181
Ser Gly Ser Ser Ser Asn Ile Gly Ser Thr Tyr Val Ser 
1               5                   10              

<210> 182
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 182
Arg Asn Asn Asn Arg Pro Ser 
1               5           

<210> 183
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 183
Gln Val Arg Ala Leu Gly Thr Ser Ser Val Val 
1               5                   10      

<210> 184
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 184
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Thr 
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Val Arg Ala Leu Gly Thr 
                85                  90                  95      
Ser Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 185
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 185
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          
Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Asp Pro Ser Asn Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Tyr Tyr Gly Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 186
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 186
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt tctacttacg tgtcttggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaaca accgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgccag gttcgtgctc tgggtacttc ttctgttgtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 187
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 187
caggtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt      60

agctgcaaag gctccggata tagcttcact aactactgga tcgcttgggt gcgccagatg     120

ccgggcaaag gtctcgagtg gatgggcatc atcgacccgt ctaacagcga cacccgttat     180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcatcag caccgcgtat     240

ctgcaatgga gcagcctgaa agcgagcgat accgcgatgt attattgcgc gcgtggtcgt     300

tactacggtt tcttcgatta ctggggccaa ggcaccctgg tgactgttag ctca           354


<210> 188
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 188
Ser Tyr Ala Met Ser 
1               5   

<210> 189
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 189
Ala Ile Ser Gly Ser Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 190
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 190
Val Val Gln Ser Ile Gly Phe Ala Val 
1               5                   

<210> 191
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 191
Ser Gly Ser Ser Ser Asn Ile Gly Val Asn Tyr Val Asn 
1               5                   10              

<210> 192
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 192
Ser Asn Asn Gln Arg Pro Ser 
1               5           

<210> 193
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 193
Ser Thr Arg Thr Arg Gln Arg Ala Val Ile Val 
1               5                   10      

<210> 194
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 194
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Val Asn 
            20                  25                  30          
Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Arg Thr Arg Gln Arg 
                85                  90                  95      
Ala Val Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 195
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 195
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Val Gln Ser Ile Gly Phe Ala Val Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 196
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 196
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt gtcaactacg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac tctaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgctct actcgtactc gtcagcgtgc tgttatcgtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 197
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 197
caggtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tcttacgcta tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgct atctctggtt ctggttctat cacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgttgtt     300

cagtctatcg gtttcgctgt ttggggccaa ggcaccctgg tgactgttag ctca           354


<210> 198
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 198
Arg Tyr Trp Met Ser 
1               5   

<210> 199
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 199
Val Ile Ser Tyr Ser Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 200
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 200
Gly Arg Ala Tyr Gly Tyr Phe Asp Pro 
1               5                   

<210> 201
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 201
Ser Gly Ser Ser Ser Asn Ile Gly Lys Lys Thr Val Ser 
1               5                   10              

<210> 202
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 202
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 203
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 203
Ser Ser Thr Thr Ser Ser Ser Arg Ser Val Val 
1               5                   10      

<210> 204
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 204
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Lys 
            20                  25                  30          
Thr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Thr Thr Ser Ser Ser 
                85                  90                  95      
Arg Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 205
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 205
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Tyr Ser Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Ala Tyr Gly Tyr Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 206
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 206
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt aaaaaaactg tgtcttggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgctct tctactactt cttcttctcg ttctgttgtg     300

tttggcggcg gcacgaagtt aaccgttctt ggccag                               336


<210> 207
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 207
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct cgttactgga tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttact ctggttctga aacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtcgt     300

gcttacggtt acttcgatcc gtggggccaa ggcaccctgg tgactgttag ctca           354


<210> 208
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 208
Asp Tyr Ala Ile Ser 
1               5   

<210> 209
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 209
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 210
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 210
His Ser Tyr Ser Phe Asp Tyr 
1               5           

<210> 211
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 211
Ser Gly Asp Asn Leu Arg Lys Lys Tyr Ala Tyr 
1               5                   10      

<210> 212
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 212
Ser Lys Ser Asn Arg Pro Ser 
1               5           

<210> 213
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 213
Gln Ser Tyr Asp Ser Gly Arg Val Val 
1               5                   

<210> 214
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 214
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Arg Lys Lys Tyr Ala 
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Gly 
        35                  40                  45              
Ser Lys Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Gly Arg Val Val 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105             

<210> 215
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 215
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Asp Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Ser Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 216
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..324
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 216
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgataacct gcgtaaaaaa tacgcttact ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat cggttctaaa tctaaccgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg ccagtcttac gactctggtc gtgttgtgtt tggcggcggc     300

acgaagttaa ccgttcttgg ccag                                            324


<210> 217
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..348
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 217
caggtgcaat tggtgcagag cggtgccgaa gtgaaaaaac cgggcagcag cgtgaaagtt      60

agctgcaaag catccggagg gacgtttact gactacgcta tctcttgggt gcgccaggcc     120

ccgggccagg gcctcgagtg gatgggcggt atcatcccga tcttcggcac tgcgaactac     180

gcccagaaat ttcagggccg ggtgaccatt accgccgatg aaagcaccag caccgcctat     240

atggaactga gcagcctgcg cagcgaagat acggccgtgt attattgcgc gcgtcattct     300

tactctttcg actactgggg ccaaggcacc ctggtgactg ttagctca                  348


<210> 218
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 218
Arg Tyr Trp Met Ser 
1               5   

<210> 219
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 219
Val Ile Ser Tyr Ser Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 220
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 220
Gly Arg Ala Tyr Gly Tyr Phe Asp Pro 
1               5                   

<210> 221
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 221
Ser Gly Ser Ser Ser Asn Ile Gly Lys Lys Thr Val Ser 
1               5                   10              

<210> 222
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 222
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 223
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 223
Gln Ser Thr Asp Ser Thr His Arg Met Ala Val 
1               5                   10      

<210> 224
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 224
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Lys 
            20                  25                  30          
Thr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Thr Asp Ser Thr His 
                85                  90                  95      
Arg Met Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 225
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 225
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Tyr Ser Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Ala Tyr Gly Tyr Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 226
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 226
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt aaaaaaactg tgtcttggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgccag tctactgact ctactcatcg tatggctgtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 227
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 227
caggtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct cgttactgga tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttact ctggttctga aacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtcgt     300

gcttacggtt acttcgatcc gtggggccaa ggcaccctgg tgactgttag ctca           354


<210> 228
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 228
Ser Tyr Ala Met Ser 
1               5   

<210> 229
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 229
Ala Ile Ser Gly Ser Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 230
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 230
Val Val Gln Ser Ile Gly Phe Ala Val 
1               5                   

<210> 231
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 231
Ser Gly Ser Ser Ser Asn Ile Gly Val Asn Tyr Val Asn 
1               5                   10              

<210> 232
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 232
Ser Asn Asn Gln Arg Pro Ser 
1               5           

<210> 233
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 233
Ser Thr Arg Thr Arg Gln Arg Ala Val Ile Val 
1               5                   10      

<210> 234
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 234
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Val Asn 
            20                  25                  30          
Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Arg Thr Arg Gln Arg 
                85                  90                  95      
Ala Val Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 235
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 235
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Val Gln Ser Ile Gly Phe Ala Val Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 236
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 236
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt gtcaactacg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac tctaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgctct actcgtactc gtcagcgtgc tgttatcgtg     300

tttggcggcg gcacgaagtt aaccgtccta ggtcag                               336


<210> 237
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 237
caggtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tcttacgcta tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgct atctctggtt ctggttctat cacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgttgtt     300

cagtctatcg gtttcgctgt ttggggccaa ggcaccctgg tgactgttag ctca           354


<210> 238
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 238
Ser Asn Ser Ala Ala Trp Asn 
1               5           

<210> 239
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 239
Arg Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
1               5                   10                  15      
Lys Ser 
        

<210> 240
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 240
Asp Val Pro Tyr Tyr Ser Asp Tyr Ser His Tyr Val Tyr Tyr Tyr Gly 
1               5                   10                  15      
Ala Trp Phe Asp Val 
            20      

<210> 241
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 241
Ser Gly Asp Ser Ile Pro Tyr Asn Tyr Ala His 
1               5                   10      

<210> 242
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 242
Asp Asp Ser Asp Arg Pro Ser 
1               5           

<210> 243
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 243
Gly Ala Tyr Asp Lys Lys Trp Val Val 
1               5                   

<210> 244
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 244
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      
Thr Ala Ser Ile Thr Cys Ser Gly Asp Ser Ile Pro Tyr Asn Tyr Ala 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Tyr Asp Lys Lys Trp Val Val 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105             

<210> 245
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 245
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          
Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              
Trp Leu Gly Arg Ile Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  
Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  
Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Ala Arg Asp Val Pro Tyr Tyr Ser Asp Tyr Ser His Tyr 
            100                 105                 110         
Val Tyr Tyr Tyr Gly Ala Trp Phe Asp Val Trp Gly Gln Gly Thr Leu 
        115                 120                 125             
Val Thr Val Ser Ser 
    130             

<210> 246
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..324
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 246
gatatcgaac tgacccagcc gccgagcgtg agcgtgagcc cgggccagac cgcgagcatt      60

acctgtagcg gcgattctat cccgtacaac tacgctcatt ggtaccagca gaaaccgggc     120

caggcgccgg tgctggtgat ctacgacgac tctgaccgtc cgagcggcat cccggaacgt     180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac ccaggcggaa     240

gacgaagcgg attattactg cggtgcttac gacaaaaaat gggttgtgtt tggcggcggc     300

acgaagttaa ccgttcttgg ccag                                            324


<210> 247
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..399
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 247
caggtgcaat tgcagcagag cggtccgggc ctggtgaaac cgagccagac cctgagcctg      60

acctgcgcga tttccggaga tagcgtgagc tctaactctg ctgcttggaa ctggattcgt     120

cagagcccga gccgtggcct cgagtggctg ggccgtatct actaccgtag caaatggtac     180

aacgactatg ccgtgagcgt gaaaagccgc attaccatta acccggatac ttcgaaaaac     240

cagtttagcc tgcaactgaa cagcgtgacc ccggaagata cggccgtgta ttattgcgcg     300

cgtgacgttc cgtactactc tgactactct cattacgttt actactacgg tgcttggttc     360

gatgtttggg gccaaggcac cctggtgact gttagctca                            399


<210> 248
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 248
Arg Tyr Trp Met Ser 
1               5   

<210> 249
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 249
Val Ile Ser Tyr Ser Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 250
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 250
Gly Arg Ala Tyr Gly Tyr Phe Asp Pro 
1               5                   

<210> 251
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 251
Ser Gly Ser Ser Ser Asn Ile Gly Lys Lys Thr Val Ser 
1               5                   10              

<210> 252
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 252
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 253
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 253
Gly Ser Thr Thr Ser Ser His Leu Tyr Val 
1               5                   10  

<210> 254
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 254
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Lys 
            20                  25                  30          
Thr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Thr Thr Ser Ser His 
                85                  90                  95      
Leu Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110     

<210> 255
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 255
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Tyr Ser Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Ala Tyr Gly Tyr Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 256
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..333
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 256
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt aaaaaaactg tgtcttggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgcggt tctactactt cttctcatct gtacgtgttt     300

ggcggcggca cgaagttaac cgttcttggc cag                                  333


<210> 257
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 257
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct cgttactgga tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttact ctggttctga aacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtcgt     300

gcttacggtt acttcgatcc gtggggccaa ggcaccctgg tgactgttag ctca           354


<210> 258
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 258
Arg Tyr Trp Met Ser 
1               5   

<210> 259
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 259
Val Ile Ser Tyr Ser Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 260
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 260
Gly Arg Ala Tyr Gly Tyr Phe Asp Pro 
1               5                   

<210> 261
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 261
Ser Gly Ser Ser Ser Asn Ile Gly Lys Lys Thr Val Ser 
1               5                   10              

<210> 262
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 262
Arg Asn Asn Gln Arg Pro Ser 
1               5           

<210> 263
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 263
Gly Ser Thr Gly Tyr Arg Gly Leu Tyr Val 
1               5                   10  

<210> 264
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 264
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Lys 
            20                  25                  30          
Thr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Thr Gly Tyr Arg Gly 
                85                  90                  95      
Leu Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110     

<210> 265
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 265
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Tyr Ser Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Ala Tyr Gly Tyr Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 266
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..333
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 266
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt aaaaaaactg tgtcttggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaacaacc agcgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgcggt tctactggtt accgtggtct gtacgtgttt     300

ggcggcggca cgaagttaac cgttcttggc cag                                  333


<210> 267
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 267
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct cgttactgga tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttact ctggttctga aacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtcgt     300

gcttacggtt acttcgatcc gtggggccaa ggcaccctgg tgactgttag ctca           354


<210> 268
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 268
Ser Tyr Ser Met Ser 
1               5   

<210> 269
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 269
Tyr Ile Ser Ser Ala Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 270
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 270
Gly Arg Ala Tyr Gly Tyr Phe Asp Tyr 
1               5                   

<210> 271
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 271
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Tyr 
1               5                   10              

<210> 272
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 272
Ser Asn Thr Lys Arg Pro Ser 
1               5           

<210> 273
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 273
Gln Val Thr Asp Phe Arg Leu His His Val Val 
1               5                   10      

<210> 274
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 274
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          
Thr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Ser Ser Asn Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Val Thr Asp Phe Arg Leu 
                85                  90                  95      
His His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 275
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 275
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Ser Ser Ala Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Ala Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 276
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 276
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt tctaacactg tgtactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctct tctaacacta aacgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgccag gttactgact tccgtctgca tcatgttgtg     300

tttggcggcg gcacgaagtt aaccgttctt ggccag                               336


<210> 277
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..354
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 277
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct tcttactcta tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttcctac atctcttctg ctggttctaa cacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggtcgt     300

gcttacggtt acttcgatta ctggggccaa ggcaccctgg tgactgttag ctca           354


<210> 278
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 278
Arg Tyr Ala Met Ser 
1               5   

<210> 279
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 279
Val Ile Ser Ser Asp Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 280
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 280
Ile Phe Ser Tyr Ala Leu Asp Tyr 
1               5               

<210> 281
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 281
Ser Gly Ser Ser Ser Asn Ile Gly Ser Tyr Tyr Val Asn 
1               5                   10              

<210> 282
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 282
Arg Asn Ser Lys Arg Pro Ser 
1               5           

<210> 283
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 283
Ser Ser Tyr Asp Ala His Ser Asp Ser Val Val 
1               5                   10      

<210> 284
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 284
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Tyr 
            20                  25                  30          
Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asn Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Ala His Ser 
                85                  90                  95      
Asp Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 285
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 285
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Ser Asp Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ile Phe Ser Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 286
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 286
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt tcttactacg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac cgtaactcta aacgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgctct tcttacgacg ctcattctga ctctgttgtg     300

tttggcggcg gcacgaagtt aaccgttctt ggccag                               336


<210> 287
<211> 351
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..351
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 287
gaagtgcaat tgctggaaag cggcggtggc ctggtgcagc cgggtggcag cctgcgtctg      60

agctgcgcgg cgtccggatt caccttttct cgttacgcta tgtcttgggt gcgccaggcc     120

ccgggcaaag gtctcgagtg ggtttccgtt atctcttctg acggtggtac tacctactat     180

gcggatagcg tgaaaggccg ctttaccatc agccgcgata attcgaaaaa caccctgtat     240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtatcttc     300

tcttacgctc tggattactg gggccaaggc accctggtga ctgttagctc a              351


<210> 288
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR1

<400> 288
Ser Tyr Trp Ile Ser 
1               5   

<210> 289
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR2

<400> 289
Ile Ile Asp Pro Ala Asn Ser Tyr Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 290
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCDR3

<400> 290
Val Glu Arg Arg Pro Arg Tyr Tyr Gly Ser Asn Tyr Tyr Gly Met Asp 
1               5                   10                  15      
Val 
    

<210> 291
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR1

<400> 291
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Asn 
1               5                   10              

<210> 292
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR2

<400> 292
Gly Asn Ser Asn Arg Pro Ser 
1               5           

<210> 293
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCDR3

<400> 293
Ser Val Arg Asp Ser Glu Gly Arg Tyr Val Val 
1               5                   10      

<210> 294
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL

<400> 294
Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          
Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Val Arg Asp Ser Glu Gly 
                85                  90                  95      
Arg Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         



<210> 295
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH

<400> 295
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Asp Pro Ala Asn Ser Tyr Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Glu Arg Arg Pro Arg Tyr Tyr Gly Ser Asn Tyr Tyr Gly 
            100                 105                 110         
Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210> 296
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..336
<223> /mol_type="unassigned DNA"
      /note="VL"
      /organism="Artificial Sequence"

<400> 296
gatatcgtgc tgacccagcc gccgagcgtg agcggtgcac cgggccagcg cgtgaccatt      60

agctgtagcg gcagcagcag caacattggt tctaactacg tgaactggta ccagcagctg     120

ccgggcacgg cgccgaaact gctgatctac ggtaactcta accgcccgag cggcgtgccg     180

gatcgcttta gcggatccaa aagcggcacc agcgccagcc tggcgattac cggcctgcaa     240

gcagaagacg aagcggatta ttactgctct gttcgtgact ctgaaggtcg ttacgttgtg     300

tttggcggcg gcacgaagtt aaccgttctt ggccag                               336


<210> 297
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..378
<223> /mol_type="unassigned DNA"
      /note="VH"
      /organism="Artificial Sequence"

<400> 297
gaagtgcaat tggtgcagag cggtgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt      60

agctgcaaag gctccggata tagcttcact tcttactgga tctcttgggt gcgccagatg     120

ccgggcaaag gtctcgagtg gatgggcatc atcgacccgg ctaacagcta cacccgttat     180

agcccgagct ttcagggcca ggtgaccatt agcgcggata aaagcatcag caccgcgtat     240

ctgcaatgga gcagcctgaa agcgagcgat accgcgatgt attattgcgc gcgtgttgaa     300

cgtcgtccgc gttactacgg ttctaactac tacggtatgg atgtttgggg ccaaggcacc     360

ctggtgactg ttagctca                                                   378


