﻿SEQUENCE LISTING

<110>   Isis Innovation Limited

<120>   BIOMARKERS FOR PROGNOSIS

<130>   P061558GB

<141>   2013-04-08

<160>   20

<170>   SeqWin2010, version 1.0

<210>   1
<211>   30
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   primer

<400>   1
ctactagcgg ccgcaatgac ctcaacacgc                                   30

<210>   2
<211>   29
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   primer

<400>   2
tagtaggcgg ccgcttattt atcatcatc                                    29

<210>   3
<211>   34
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   primer

<400>   3
gtggtggaat tcatgcaggt caccctgaag accc                              34

<210>   4
<211>   36
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   primer

<400>   4
tctagactcg agatcttcat caaagttctg ctgtag                            36

<210>   5
<211>   34
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   primer

<400>   5
gtggtggaat tcatgcaggt caccctgaag accc                              34

<210>   6
<211>   33
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   primer

<400>   6
tctagactcg agagactgac ccgtcacaag tgc                               33

<210>   7
<211>   37
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   primer

<400>   7
gtggtggaat tcatggcagt gtccacacca gcaccag                           37

<210>   8
<211>   36
<212>   DNA
<213>   primer

<400>   8
tctagactcg agatcttcat caaagttctg ctgtag                            36

<210>   9
<211>   19
<212>   RNA
<213>   siRNA

<400>   9
gaugcaacga gugcacuug                                               19

<210>   10
<211>   3648
<212>   DNA
<213>   Homo sapiens

<400>   10
atgacctcaa ccggccagga ttccaccaca accaggcagc gaagaagtag gcagaacccc  60
cagtcgcccc ctcaggactc cagtgtcact tcgaagcgaa atattaaaaa gggagccgtt  120
ccccgctcta tccccaatct agcggaggta aagaagaaag gcaaaatgaa gaagctcggc  180
caagcaatgg aagaagacct aatcgtggga ctgcaaggga tggatctgaa ccttgaggct  240
gaagcactgg ctggcactgg cttggtgttg gatgagcagt taaatgaatt ccattgcctc  300
tgggatgaca gcttcccgga aggccctgag cggctccatg ccatcaagga gcaactgatc  360
caggagggcc tcctagatcg ctgcgtgtcc tttcaggccc ggtttgctga aaaggaagag  420
ctgatgttgg ttcacagcct agaatatatt gatctgatgg aaacaaccca gtacatgaat  480
gagggagaac tccgtgtcct agcagacacc tacgactcag tttatctgca tccgaactca  540
tactcctgtg cctgcctggc ctcaggctct gtcctcaggc tggtggatgc ggtcctgggg  600
gctgagatcc ggaatggcat ggccatcatt aggcctcctg gacatcacgc ccagcacagt  660
cttatggatg gctattgcat gttcaaccac gtggctgtgg cagcccgcta tgctcaacag  720
aaacaccgca tccggagggt ccttatcgta gattgggatg tgcaccacgg tcaaggaaca  780
cagttcacct tcgaccagga ccccagtgtc ctctatttct ccatccaccg ctacgagcag  840
ggtaggttct ggccccacct gaaggcctct aactggtcca ccacaggttt cggccaaggc  900
caaggatata ccatcaatgt gccttggaac caggtgggga tgcgggatgc tgactacatt  960
gctgctttcc tgcacgtcct gctgccagtc gccctcgagt tccagcctca gctggtcctg  1020
gtggctgctg gatttgatgc cctgcaaggg gaccccaagg gtgagatggc cgccactccg  1080
gcagggttcg cccagctaac ccacctgctc atgggtctgg caggaggcaa gctgatcctg  1140
tctctggagg gtggctacaa cctccgcgcc ctggctgaag gcgtcagtgc ttcgctccac  1200
acccttctgg gagacccttg ccccatgctg gagtcacctg gtgccccctg ccggagtgcc  1260
caggcttcag tttcctgtgc tctggaagcc cttgagccct tctgggaggt tcttgtgaga  1320
tcaactgaga ccgtggagag ggacaacatg gaggaggaca atgtagagga gagcgaggag  1380
gaaggaccct gggagccccc tgtgctccca atcctgacat ggccagtgct acagtctcgc  1440
acagggctgg tctatgacca aaatatgatg aatcactgca acttgtggga cagccaccac  1500
cctgaggtac cccagcgcat cttgcggatc atgtgccgtc tggaggagct gggccttgcc  1560
gggcgctgcc tcaccctgac accgcgccct gccacagagg ctgagctgct cacctgtcac  1620
agtgctgagt acgtgggtca tctccgggcc acagagaaaa tgaaaacccg ggagctgcac  1680
cgtgagagtt ccaactttga ctccatctat atctgcccca gtaccttcgc ctgtgcacag  1740
cttgccactg gcgctgcctg ccgcctggtg gaggctgtgc tctcaggaga ggttctgaat  1800
ggtgctgctg tggtgcgtcc cccaggacac cacgcagagc aggatgcagc ttgcggtttt  1860
tgctttttca actctgtggc tgtggctgct cgccatgccc agactatcag tgggcatgcc  1920
ctacggatcc tgattgtgga ttgggatgtc caccacggta atggaactca gcacatgttt  1980
gaggatgacc ccagtgtgct atatgtgtcc ctgcaccgct atgatcatgg caccttcttc  2040
cccatggggg atgagggtgc cagcagccag atcggccggg ctgcgggcac aggcttcacc  2100
gtcaacgtgg catggaacgg gccccgcatg ggtgatgctg actacctagc tgcctggcat  2160
cgcctggtgc ttcccattgc ctacgagttt aacccagaac tggtgctggt ctcagctggc  2220
tttgatgctg cacgggggga tccgctgggg ggctgccagg tgtcacctga gggttatgcc  2280
cacctcaccc acctgctgat gggccttgcc agtggccgca ttatccttat cctagagggt  2340
ggctataacc tgacatccat ctcagagtcc atggctgcct gcactcgctc cctccttgga  2400
gacccaccac ccctgctgac cctgccacgg cccccactat caggggccct ggcctcaatc  2460
actgagacca tccaagtcca tcgcagatac tggcgcagct tacgggtcat gaaggtagaa  2520
gacagagaag gaccctccag ttctaagttg gtcaccaaga aggcacccca accagccaaa  2580
cctaggttag ctgagcggat gaccacacga gaaaagaagg ttctggaagc aggcatgggg  2640
aaagtcacct cggcatcatt tggggaagag tccactccag gccagactaa ctcagagaca  2700
gctgtggtgg ccctcactca ggaccagccc tcagaggcag ccacaggggg agccactctg  2760
gcccagacca tttctgaggc agccattggg ggagccatgc tgggccagac cacctcagag  2820
gaggctgtcg ggggagccac tccggaccag accacctcag aggagactgt gggaggagcc  2880
attctggacc agaccacctc agaggatgct gttgggggag ccacgctggg ccagactacc  2940
tcagaggagg ctgtaggagg agctacactg gcccagacca tctcggaggc agccatggag  3000
ggagccacac tggaccagac tacgtcagag gaggctccag ggggcaccga gctgatccaa  3060
actcctctag cctcgagcac agaccaccag acccccccaa cctcacctgt gcagggaact  3120
acaccccaga tatctcccag tacactgatt gggagtctca ggaccttgga gctaggcagc  3180
gaatctcagg gggcctcaga atctcaggcc ccaggagagg agaacctact aggagaggca  3240
gctggaggtc aggacatggc tgattcgatg ctgatgcagg gatctagggg cctcactgat  3300
caggccatat tttatgctgt gacaccactg ccctggtgtc cccatttggt ggcagtatgc  3360
cccatacctg cagcaggcct agacgtgacc caaccttgtg gggactgtgg aacaatccaa  3420
gagaattggg tgtgtctctc ttgctatcag gtctactgtg gtcgttacat caatggccac  3480
atgctccaac accatggaaa ttctggacac ccgctggtcc tcagctacat cgacctgtca  3540
gcctggtgtt actactgtca ggcctatgtc caccaccagg ctctcctaga tgtgaagaac  3600
atcgcccacc agaacaagtt tggggaggat atgccccacc cacactaa               3648

<210>   11
<211>   1215
<212>   PRT
<213>   Homo sapiens

<400>   11
Met Thr Ser Thr Gly Gln Asp Ser Thr Thr Thr Arg Gln Arg Arg Ser 
1               5                   10                  15      

Arg Gln Asn Pro Gln Ser Pro Pro Gln Asp Ser Ser Val Thr Ser Lys 
            20                  25                  30          

Arg Asn Ile Lys Lys Gly Ala Val Pro Arg Ser Ile Pro Asn Leu Ala 
        35                  40                  45              

Glu Val Lys Lys Lys Gly Lys Met Lys Lys Leu Gly Gln Ala Met Glu 
    50                  55                  60                  

Glu Asp Leu Ile Val Gly Leu Gln Gly Met Asp Leu Asn Leu Glu Ala 
65                  70                  75                  80  

Glu Ala Leu Ala Gly Thr Gly Leu Val Leu Asp Glu Gln Leu Asn Glu 
                85                  90                  95      

Phe His Cys Leu Trp Asp Asp Ser Phe Pro Glu Gly Pro Glu Arg Leu 
            100                 105                 110         

His Ala Ile Lys Glu Gln Leu Ile Gln Glu Gly Leu Leu Asp Arg Cys 
        115                 120                 125             

Val Ser Phe Gln Ala Arg Phe Ala Glu Lys Glu Glu Leu Met Leu Val 
    130                 135                 140                 

His Ser Leu Glu Tyr Ile Asp Leu Met Glu Thr Thr Gln Tyr Met Asn 
145                 150                 155                 160 

Glu Gly Glu Leu Arg Val Leu Ala Asp Thr Tyr Asp Ser Val Tyr Leu 
                165                 170                 175     

His Pro Asn Ser Tyr Ser Cys Ala Cys Leu Ala Ser Gly Ser Val Leu 
            180                 185                 190         

Arg Leu Val Asp Ala Val Leu Gly Ala Glu Ile Arg Asn Gly Met Ala 
        195                 200                 205             

Ile Ile Arg Pro Pro Gly His His Ala Gln His Ser Leu Met Asp Gly 
    210                 215                 220                 

Tyr Cys Met Phe Asn His Val Ala Val Ala Ala Arg Tyr Ala Gln Gln 
225                 230                 235                 240 

Lys His Arg Ile Arg Arg Val Leu Ile Val Asp Trp Asp Val His His 
                245                 250                 255     

Gly Gln Gly Thr Gln Phe Thr Phe Asp Gln Asp Pro Ser Val Leu Tyr 
            260                 265                 270         

Phe Ser Ile His Arg Tyr Glu Gln Gly Arg Phe Trp Pro His Leu Lys 
        275                 280                 285             

Ala Ser Asn Trp Ser Thr Thr Gly Phe Gly Gln Gly Gln Gly Tyr Thr 
    290                 295                 300                 

Ile Asn Val Pro Trp Asn Gln Val Gly Met Arg Asp Ala Asp Tyr Ile 
305                 310                 315                 320 

Ala Ala Phe Leu His Val Leu Leu Pro Val Ala Leu Glu Phe Gln Pro 
                325                 330                 335     

Gln Leu Val Leu Val Ala Ala Gly Phe Asp Ala Leu Gln Gly Asp Pro 
            340                 345                 350         

Lys Gly Glu Met Ala Ala Thr Pro Ala Gly Phe Ala Gln Leu Thr His 
        355                 360                 365             

Leu Leu Met Gly Leu Ala Gly Gly Lys Leu Ile Leu Ser Leu Glu Gly 
    370                 375                 380                 

Gly Tyr Asn Leu Arg Ala Leu Ala Glu Gly Val Ser Ala Ser Leu His 
385                 390                 395                 400 

Thr Leu Leu Gly Asp Pro Cys Pro Met Leu Glu Ser Pro Gly Ala Pro 
                405                 410                 415     

Cys Arg Ser Ala Gln Ala Ser Val Ser Cys Ala Leu Glu Ala Leu Glu 
            420                 425                 430         

Pro Phe Trp Glu Val Leu Val Arg Ser Thr Glu Thr Val Glu Arg Asp 
        435                 440                 445             

Asn Met Glu Glu Asp Asn Val Glu Glu Ser Glu Glu Glu Gly Pro Trp 
    450                 455                 460                 

Glu Pro Pro Val Leu Pro Ile Leu Thr Trp Pro Val Leu Gln Ser Arg 
465                 470                 475                 480 

Thr Gly Leu Val Tyr Asp Gln Asn Met Met Asn His Cys Asn Leu Trp 
                485                 490                 495     

Asp Ser His His Pro Glu Val Pro Gln Arg Ile Leu Arg Ile Met Cys 
            500                 505                 510         

Arg Leu Glu Glu Leu Gly Leu Ala Gly Arg Cys Leu Thr Leu Thr Pro 
        515                 520                 525             

Arg Pro Ala Thr Glu Ala Glu Leu Leu Thr Cys His Ser Ala Glu Tyr 
    530                 535                 540                 

Val Gly His Leu Arg Ala Thr Glu Lys Met Lys Thr Arg Glu Leu His 
545                 550                 555                 560 

Arg Glu Ser Ser Asn Phe Asp Ser Ile Tyr Ile Cys Pro Ser Thr Phe 
                565                 570                 575     

Ala Cys Ala Gln Leu Ala Thr Gly Ala Ala Cys Arg Leu Val Glu Ala 
            580                 585                 590         

Val Leu Ser Gly Glu Val Leu Asn Gly Ala Ala Val Val Arg Pro Pro 
        595                 600                 605             

Gly His His Ala Glu Gln Asp Ala Ala Cys Gly Phe Cys Phe Phe Asn 
    610                 615                 620                 

Ser Val Ala Val Ala Ala Arg His Ala Gln Thr Ile Ser Gly His Ala 
625                 630                 635                 640 

Leu Arg Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr 
                645                 650                 655     

Gln His Met Phe Glu Asp Asp Pro Ser Val Leu Tyr Val Ser Leu His 
            660                 665                 670         

Arg Tyr Asp His Gly Thr Phe Phe Pro Met Gly Asp Glu Gly Ala Ser 
        675                 680                 685             

Ser Gln Ile Gly Arg Ala Ala Gly Thr Gly Phe Thr Val Asn Val Ala 
    690                 695                 700                 

Trp Asn Gly Pro Arg Met Gly Asp Ala Asp Tyr Leu Ala Ala Trp His 
705                 710                 715                 720 

Arg Leu Val Leu Pro Ile Ala Tyr Glu Phe Asn Pro Glu Leu Val Leu 
                725                 730                 735     

Val Ser Ala Gly Phe Asp Ala Ala Arg Gly Asp Pro Leu Gly Gly Cys 
            740                 745                 750         

Gln Val Ser Pro Glu Gly Tyr Ala His Leu Thr His Leu Leu Met Gly 
        755                 760                 765             

Leu Ala Ser Gly Arg Ile Ile Leu Ile Leu Glu Gly Gly Tyr Asn Leu 
    770                 775                 780                 

Thr Ser Ile Ser Glu Ser Met Ala Ala Cys Thr Arg Ser Leu Leu Gly 
785                 790                 795                 800 

Asp Pro Pro Pro Leu Leu Thr Leu Pro Arg Pro Pro Leu Ser Gly Ala 
                805                 810                 815     

Leu Ala Ser Ile Thr Glu Thr Ile Gln Val His Arg Arg Tyr Trp Arg 
            820                 825                 830         

Ser Leu Arg Val Met Lys Val Glu Asp Arg Glu Gly Pro Ser Ser Ser 
        835                 840                 845             

Lys Leu Val Thr Lys Lys Ala Pro Gln Pro Ala Lys Pro Arg Leu Ala 
    850                 855                 860                 

Glu Arg Met Thr Thr Arg Glu Lys Lys Val Leu Glu Ala Gly Met Gly 
865                 870                 875                 880 

Lys Val Thr Ser Ala Ser Phe Gly Glu Glu Ser Thr Pro Gly Gln Thr 
                885                 890                 895     

Asn Ser Glu Thr Ala Val Val Ala Leu Thr Gln Asp Gln Pro Ser Glu 
            900                 905                 910         

Ala Ala Thr Gly Gly Ala Thr Leu Ala Gln Thr Ile Ser Glu Ala Ala 
        915                 920                 925             

Ile Gly Gly Ala Met Leu Gly Gln Thr Thr Ser Glu Glu Ala Val Gly 
    930                 935                 940                 

Gly Ala Thr Pro Asp Gln Thr Thr Ser Glu Glu Thr Val Gly Gly Ala 
945                 950                 955                 960 

Ile Leu Asp Gln Thr Thr Ser Glu Asp Ala Val Gly Gly Ala Thr Leu 
                965                 970                 975     

Gly Gln Thr Thr Ser Glu Glu Ala Val Gly Gly Ala Thr Leu Ala Gln 
            980                 985                 990         

Thr Thr Ser Glu Ala Ala Met Glu Gly Ala Thr Leu Asp Gln Thr Thr 
        995                 1000                1005            

Ser Glu Glu Ala Pro Gly Gly Thr Glu Leu Ile Gln Thr Pro Leu Ala 
    1010                1015                1020                

Ser Ser Thr Asp His Gln Thr Pro Pro Thr Ser Pro Val Gln Gly Thr 
1025                1030                1035                1040

Thr Pro Gln Ile Ser Pro Ser Thr Leu Ile Gly Ser Leu Arg Thr Leu 
                1045                1050                1055    

Glu Leu Gly Ser Glu Ser Gln Gly Ala Ser Glu Ser Gln Ala Pro Gly 
            1060                1065                1070        

Glu Glu Asn Leu Leu Gly Glu Ala Ala Gly Gly Gln Asp Met Ala Asp 
        1075                1080                1085            

Ser Met Leu Met Gln Gly Ser Arg Gly Leu Thr Asp Gln Ala Ile Phe 
    1090                1095                1100                

Tyr Ala Val Thr Pro Leu Pro Trp Cys Pro His Leu Val Ala Val Cys 
1105                1110                1115                1120

Pro Ile Pro Ala Ala Gly Leu Asp Val Thr Gln Pro Cys Gly Asp Cys 
                1125                1130                1135    

Gly Thr Ile Gln Glu Asn Trp Val Cys Leu Ser Cys Tyr Gln Val Tyr 
            1140                1145                1150        

Cys Gly Arg Tyr Ile Asn Gly His Met Leu Gln His His Gly Asn Ser 
        1155                1160                1165            

Gly His Pro Leu Val Leu Ser Tyr Ile Asp Leu Ser Ala Trp Cys Tyr 
    1170                1175                1180                

Tyr Cys Gln Ala Tyr Val His His Gln Ala Leu Leu Asp Val Lys Asn 
1185                1190                1195                1200

Ile Ala His Gln Asn Lys Phe Gly Glu Asp Met Pro His Pro His 
                1205                1210                1215

<210>   12
<211>   2912
<212>   DNA
<213>   Homo sapiens

<400>   12
cagttgcttc agcgtcccgg tgtggctgtg ccgttggtcc tgtgcggtca cttagccaag  60
atgcctgagg aaacccagac ccaagaccaa ccgatggagg aggaggaggt tgagacgttc  120
gcctttcagg cagaaattgc ccagttgatg tcattgatca tcaatacttt ctactcgaac  180
aaagagatct ttctgagaga gctcatttca aattcatcag atgcattgga caaaatccgg  240
tatgaaactt tgacagatcc cagtaaatta gactctggga aagagctgca tattaacctt  300
ataccgaaca aacaagatcg aactctcact attgtggata ctggaattgg aatgaccaag  360
gctgacttga tcaataacct tggtactatc gccaagtctg ggaccaaagc gttcatggaa  420
gctttgcagg ctggtgcaga tatctctatg attggccagt tcggtgttgg tttttattct  480
gcttatttgg ttgctgagaa agtaactgtg atcaccaaac ataacgatga tgagcagtac  540
gcttgggagt cctcagcagg gggatcattc acagtgagga cagacacagg tgaacctatg  600
ggtcgtggaa caaaagttat cctacacctg aaagaagacc aaactgagta cttggaggaa  660
cgaagaataa aggagattgt gaagaaacat tctcagttta ttggatatcc cattactctt  720
tttgtggaga aggaacgtga taaagaagta agcgatgatg aggctgaaga aaaggaagac  780
aaagaagaag aaaaagaaaa agaagagaaa gagtcggaag acaaacctga aattgaagat  840
gttggttctg atgaggaaga agaaaagaag gatggtgaca agaagaagaa gaagaagatt  900
aaggaaaagt acatcgatca agaagagctc aacaaaacaa agcccatctg gaccagaaat  960
cccgacgata ttactaatga ggagtacgga gaattctata agagcttgac caatgactgg  1020
gaagatcact tggcagtgaa gcatttttca gttgaaggac agttggaatt cagagccctt  1080
ctatttgtcc cacgacgtgc tccttttgat ctgtttgaaa acagaaagaa aaagaacaat  1140
atcaaattgt atgtacgcag agttttcatc atggataact gtgaggagct aatccctgaa  1200
tatctgaact tcattagagg ggtggtagac tcggaggatc tccctctaaa catatcccgt  1260
gagatgttgc aacaaagcaa aattttgaaa gttatcagga agaatttggt caaaaaatgc  1320
ttagaactct ttactgaact ggcggaagat aaagagaact acaagaaatt ctatgagcag  1380
ttctctaaaa acataaagct tggaatacac gaagactctc aaaatcggaa gaagctttca  1440
gagctgttaa ggtactacac atctgcctct ggtgatgaga tggtttctct caaggactac  1500
tgcaccagaa tgaaggagaa ccagaaacat atctattata tcacaggtga gaccaaggac  1560
caggtagcta actcagcctt tgtggaacgt cttcggaaac atggcttaga agtgatctat  1620
atgattgagc ccattgatga gtactgtgtc caacagctga aggaatttga ggggaagact  1680
ttagtgtcag tcaccaaaga aggcctggaa cttccagagg atgaagaaga gaaaaagaag  1740
caggaagaga aaaaaacaaa gtttgagaac ctctgcaaaa tcatgaaaga catattggag  1800
aaaaaagttg aaaaggtggt tgtgtcaaac cgattggtga catctccatg ctgtattgtc  1860
acaagcacat atggctggac agcaaacatg gagagaatca tgaaagctca agccctaaga  1920
gacaactcaa caatgggtta catggcagca aagaaacacc tggagataaa ccctgaccat  1980
tccattattg agaccttaag gcaaaaggca gaggctgata agaacgacaa gtctgtgaag  2040
gatctggtca tcttgcttta tgaaactgcg ctcctgtctt ctggcttcag tctggaagat  2100
ccccagacac atgctaacag gatctacagg atgatcaaac ttggtctggg tattgatgaa  2160
gatgacccta ctgctgatga taccagtgct gctgtaactg aagaaatgcc accccttgaa  2220
ggagatgacg acacatcacg catggaagaa gtagactaat ctctggctga gggatgactt  2280
acctgttcag tactctacaa ttcctctgat aatatatttt caaggatgtt tttctttatt  2340
tttgttaata ttaaaaagtc tgtatggcat gacaactact ttaaggggaa gataagattt  2400
ctgtctacta agtgatgctg tgatacctta ggcactaaag cagagctagt aatgcttttt  2460
gagtttcatg ttggttcttt cacagatggg gtaacgtgca ctgtaagacg tatgtaacat  2520
gatgttaact ttgtgtggtc taaagtgttt agctgtcaag ccggatgcct aagtagacca  2580
aatcttgtta ttgaagtgtt ctgagctgta tcttgatgtt tagaaaagta ttcgttacat  2640
cttgtaggat ctactttttg aacttttcat tccctgtagt tgacaattct gcatgtacta  2700
gtcctctaga aataggttaa actgaagcaa cttgatggaa ggatctctcc acagggcttg  2760
ttttccaaag aaaagtattg tttggaggag caaagttaaa agcctaccta agcatatcgt  2820
aaagctgttc aaatactcga gcccagtctt gtggatggaa atgtagtgct cgagtcacat  2880
tctgcttaaa gttgtaacaa atacagatga gt                                2912

<210>   13
<211>   732
<212>   PRT
<213>   Homo sapiens

<400>   13
Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 
1               5                   10                  15      

Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu 
            20                  25                  30          

Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu 
        35                  40                  45              

Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu 
    50                  55                  60                  

Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu 
65                  70                  75                  80  

Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile 
                85                  90                  95      

Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys 
            100                 105                 110         

Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile 
        115                 120                 125             

Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val 
    130                 135                 140                 

Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr 
145                 150                 155                 160 

Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr 
                165                 170                 175     

Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu 
            180                 185                 190         

Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys 
        195                 200                 205             

Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys 
    210                 215                 220                 

Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp 
225                 230                 235                 240 

Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro 
                245                 250                 255     

Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly 
            260                 265                 270         

Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu 
        275                 280                 285             

Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile 
    290                 295                 300                 

Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp 
305                 310                 315                 320 

Glu Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu 
                325                 330                 335     

Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe 
            340                 345                 350         

Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val 
        355                 360                 365             

Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe 
    370                 375                 380                 

Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg 
385                 390                 395                 400 

Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu 
                405                 410                 415     

Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu 
            420                 425                 430         

Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly 
        435                 440                 445             

Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg 
    450                 455                 460                 

Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr 
465                 470                 475                 480 

Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly 
                485                 490                 495     

Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg 
            500                 505                 510         

Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr 
        515                 520                 525             

Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val 
    530                 535                 540                 

Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys 
545                 550                 555                 560 

Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys 
                565                 570                 575     

Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu 
            580                 585                 590         

Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala 
        595                 600                 605             

Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr 
    610                 615                 620                 

Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His 
625                 630                 635                 640 

Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp 
                645                 650                 655     

Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu 
            660                 665                 670         

Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile 
        675                 680                 685             

Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr 
    690                 695                 700                 

Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu 
705                 710                 715                 720 

Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp 
                725                 730         

<210>   14
<211>   2543
<212>   DNA
<213>   Homo Sapiens

<400>   14
ctccggcgca gtgttgggac tgtctgggta tcggaaagca agcctacgtt gctcactatt  60
acgtataatc cttttctttt caagatgcct gaggaagtgc accatggaga ggaggaggtg  120
gagacttttg cctttcaggc agaaattgcc caactcatgt ccctcatcat caataccttc  180
tattccaaca aggagatttt ccttcgggag ttgatctcta atgcttctga tgccttggac  240
aagattcgct atgagagcct gacagaccct tcgaagttgg acagtggtaa agagctgaaa  300
attgacatca tccccaaccc tcaggaacgt accctgactt tggtagacac aggcattggc  360
atgaccaaag ctgatctcat aaataatttg ggaaccattg ccaagtctgg tactaaagca  420
ttcatggagg ctcttcaggc tggtgcagac atctccatga ttgggcagtt tggtgttggc  480
ttttattctg cctacttggt ggcagagaaa gtggttgtga tcagaaagca caacgatgat  540
gaacagtatg cttgggagtc ttctgctgga ggttccttca ctgtgcgtgc tgaccatggt  600
gagcccattg gcatgggtac caaagtgatc ctccatctta aagaagatca gacagagtac  660
ctagaagaga ggcgggtcaa agaagtagtg aagaagcatt ctcagttcat aggctatccc  720
atcacccttt atttggagaa ggaacgagag aaggaaatta gtgatgatga ggcagaggaa  780
gagaaaggtg agaaagaaga ggaagataaa gatgatgaag aaaagcccaa gatcgaagat  840
gtgggttcag atgaggagga tgacagcggt aaggataaga agaagaaaac taagaagatc  900
aaagagaaat acattgatca ggaagaacta aacaagacca agcctatttg gaccagaaac  960
cctgatgaca tcacccaaga ggagtatgga gaattctaca agagcctcac taatgactgg  1020
gaagaccact tggcagtcaa gcacttttct gtagaaggtc agttggaatt cagggcattg  1080
ctatttattc ctcgtcgggc tccctttgac ctttttgaga acaagaagaa aaagaacaac  1140
atcaaactct atgtccgccg tgtgttcatc atggacagct gtgatgagtt gataccagag  1200
tatctcaatt ttatccgtgg tgtggttgac tctgaggatc tgcccctgaa catctcccga  1260
gaaatgctcc agcagagcaa aatcttgaaa gtcattcgca aaaacattgt taagaagtgc  1320
cttgagctct tctctgagct ggcagaagac aaggagaatt acaagaaatt ctatgaggca  1380
ttctctaaaa atctcaagct tggaatccac gaagactcca ctaaccgccg ccgcctgtct  1440
gagctgctgc gctatcatac ctcccagtct ggagatgaga tgacatctct gtcagagtat  1500
gtttctcgca tgaaggagac acagaagtcc atctattaca tcactggtga gagcaaagag  1560
caggtggcca actcagcttt tgtggagcga gtgcggaaac ggggcttcga ggtggtatat  1620
atgaccgagc ccattgacga gtactgtgtg cagcagctca aggaatttga tgggaagagc  1680
ctggtctcag ttaccaagga gggtctggag ctgcctgagg atgaggagga gaagaagaag  1740
atggaagaga gcaaggcaaa gtttgagaac ctctgcaagc tcatgaaaga aatcttagat  1800
aagaaggttg agaaggtgac aatctccaat agacttgtgt cttcaccttg ctgcattgtg  1860
accagcacct acggctggac agccaatatg gagcggatca tgaaagccca ggcacttcgg  1920
gacaactcca ccatgggcta tatgatggcc aaaaagcacc tggagatcaa ccctgaccac  1980
cccattgtgg agacgctgcg gcagaaggct gaggccgaca agaatgataa ggcagttaag  2040
gacctggtgg tgctgctgtt tgaaaccgcc ctgctatctt ctggcttttc ccttgaggat  2100
ccccagaccc actccaaccg catctatcgc atgatcaagc taggtctagg tattgatgaa  2160
gatgaagtgg cagcagagga acccaatgct gcagttcctg atgagatccc ccctctcgag  2220
ggcgatgagg atgcgtctcg catggaagaa gtcgattagg ttaggagttc atagttggaa  2280
aacttgtgcc cttgtatagt gtccccatgg gctcccactg cagcctcgag tgcccctgtc  2340
ccacctggct ccccctgctg gtgtctagtg tttttttccc tctcctgtcc ttgtgttgaa  2400
ggcagtaaac taagggtgtc aagccccatt ccctctctac tcttgacagc aggattggat  2460
gttgtgtatt gtggtttatt ttattttctt cattttgttc tgaaattaaa gtatgcaaaa  2520
taaagaatat gccgttttta tac                                          2543

<210>   15
<211>   724
<212>   PRT
<213>   Homo sapiens

<400>   15
Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala 
1               5                   10                  15      

Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe 
            20                  25                  30          

Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser 
        35                  40                  45              

Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys 
    50                  55                  60                  

Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln 
65                  70                  75                  80  

Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala 
                85                  90                  95      

Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala 
            100                 105                 110         

Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln 
        115                 120                 125             

Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val 
    130                 135                 140                 

Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser 
145                 150                 155                 160 

Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly 
                165                 170                 175     

Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
            180                 185                 190         

Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe 
        195                 200                 205             

Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu 
    210                 215                 220                 

Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu 
225                 230                 235                 240 

Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp 
                245                 250                 255     

Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile 
            260                 265                 270         

Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile 
        275                 280                 285             

Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe 
    290                 295                 300                 

Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His 
305                 310                 315                 320 

Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro 
                325                 330                 335     

Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn 
            340                 345                 350         

Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu 
        355                 360                 365             

Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu 
    370                 375                 380                 

Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile 
385                 390                 395                 400 

Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe 
                405                 410                 415     

Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala 
            420                 425                 430         

Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg 
        435                 440                 445             

Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp 
    450                 455                 460                 

Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln 
465                 470                 475                 480 

Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn 
                485                 490                 495     

Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr 
            500                 505                 510         

Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe 
        515                 520                 525             

Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro 
    530                 535                 540                 

Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe 
545                 550                 555                 560 

Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu 
                565                 570                 575     

Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val 
            580                 585                 590         

Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
        595                 600                 605             

Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys 
    610                 615                 620                 

His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln 
625                 630                 635                 640 

Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val 
                645                 650                 655     

Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp 
            660                 665                 670         

Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu 
        675                 680                 685             

Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val 
    690                 695                 700                 

Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met 
705                 710                 715                 720 

Glu Glu Val Asp 
                

<210>   16
<211>   409
<212>   PRT
<213>   Homo sapiens

<400>   16
Met Gln Val Thr Leu Lys Thr Leu Gln Gln Gln Thr Phe Lys Ile Asp 
1               5                   10                  15      

Ile Asp Pro Glu Glu Thr Val Lys Ala Leu Lys Glu Lys Ile Glu Ser 
            20                  25                  30          

Glu Lys Gly Lys Asp Ala Phe Pro Val Ala Gly Gln Lys Leu Ile Tyr 
        35                  40                  45              

Ala Gly Lys Ile Leu Asn Asp Asp Thr Ala Leu Lys Glu Tyr Lys Ile 
    50                  55                  60                  

Asp Glu Lys Asn Phe Val Val Val Met Val Thr Lys Pro Lys Ala Val 
65                  70                  75                  80  

Ser Thr Pro Ala Pro Ala Thr Thr Gln Gln Ser Ala Pro Ala Ser Thr 
                85                  90                  95      

Thr Ala Val Thr Ser Ser Thr Thr Thr Thr Val Ala Gln Ala Pro Thr 
            100                 105                 110         

Pro Val Pro Ala Leu Ala Pro Thr Ser Thr Pro Ala Ser Ile Thr Pro 
        115                 120                 125             

Ala Ser Ala Thr Ala Ser Ser Glu Pro Ala Pro Ala Ser Ala Ala Lys 
    130                 135                 140                 

Gln Glu Lys Pro Ala Glu Lys Pro Ala Glu Thr Pro Val Ala Thr Ser 
145                 150                 155                 160 

Pro Thr Ala Thr Asp Ser Thr Ser Gly Asp Ser Ser Arg Ser Asn Leu 
                165                 170                 175     

Phe Glu Asp Ala Thr Ser Ala Leu Val Thr Gly Gln Ser Tyr Glu Asn 
            180                 185                 190         

Met Val Thr Glu Ile Met Ser Met Gly Tyr Glu Arg Glu Gln Val Ile 
        195                 200                 205             

Ala Ala Leu Arg Ala Ser Phe Asn Asn Pro Asp Arg Ala Val Glu Tyr 
    210                 215                 220                 

Leu Leu Met Gly Ile Pro Gly Asp Arg Glu Ser Gln Ala Val Val Asp 
225                 230                 235                 240 

Pro Pro Gln Ala Ala Ser Thr Gly Ala Pro Gln Ser Ser Ala Val Ala 
                245                 250                 255     

Ala Ala Ala Ala Thr Thr Thr Ala Thr Thr Thr Thr Thr Ser Ser Gly 
            260                 265                 270         

Gly His Pro Leu Glu Phe Leu Arg Asn Gln Pro Gln Phe Gln Gln Met 
        275                 280                 285             

Arg Gln Ile Ile Gln Gln Asn Pro Ser Leu Leu Pro Ala Leu Leu Gln 
    290                 295                 300                 

Gln Ile Gly Arg Glu Asn Pro Gln Leu Leu Gln Gln Ile Ser Gln His 
305                 310                 315                 320 

Gln Glu His Phe Ile Gln Met Leu Asn Glu Pro Val Gln Glu Ala Gly 
                325                 330                 335     

Gly Gln Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Ala Glu Ala 
            340                 345                 350         

Gly Ser Gly His Met Asn Tyr Ile Gln Val Thr Pro Gln Glu Lys Glu 
        355                 360                 365             

Ala Ile Glu Arg Leu Lys Ala Leu Gly Phe Pro Glu Gly Leu Val Ile 
    370                 375                 380                 

Gln Ala Tyr Phe Ala Cys Glu Lys Asn Glu Asn Leu Ala Ala Asn Phe 
385                 390                 395                 400 

Leu Leu Gln Gln Asn Phe Asp Glu Asp 
                405                 

<210>   17
<211>   121
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Homo sapiens

<400>   17
Met Pro Ser Asp Arg Pro Phe Lys Gln Arg Arg Ser Phe Ala Asp Arg 
1               5                   10                  15      

Cys Lys Glu Val Gln Gln Ile Arg Asp Gln His Pro Ser Lys Ile Pro 
            20                  25                  30          

Val Ile Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp 
        35                  40                  45              

Lys Thr Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Val 
    50                  55                  60                  

Lys Ile Ile Arg Arg Arg Leu Gln Leu Asn Pro Thr Gln Ala Phe Phe 
65                  70                  75                  80  

Leu Leu Val Asn Gln His Ser Met Val Ser Val Ser Thr Pro Ile Ala 
                85                  90                  95      

Asp Ile Tyr Glu Gln Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val 
            100                 105                 110         

Tyr Ala Ser Gln Glu Thr Phe Gly Phe 
        115                 120     

<210>   18
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   18
Asp Pro Glu Glu Thr Val Lys Ala Leu Lys Glu Lys Ile Glu 
1               5                   10                  

<210>   19
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   19
Pro Ala Pro Ala Ser Ala Ala Lys Gln Glu Lys Pro Ala Glu 
1               5                   10                  

<210>   20
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   20
Val Ala Thr Ser Pro Thr Ala Thr Asp Ser Thr Ser Gly Asp 
1               5                   10                  

