﻿               SEQUENCE LISTING

<110> GENETHON
      CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

<120> SYSTEME D'EXPRESSION POUR UNE THERAPIE GENETIQUE SELECTIVE

<130> G143-B-33520 PCT

<150>  FR 13.53306
<151>  2013-04-11

<160> 29

<170> BiSSAP 1.2

<210> 1
<211> 603
<212> PRT
<213> Homo sapiens

<220> 
<223> N° Accession NCBI: NP_000243.1

<400> 1
Met Ala Ser Ala Ser Thr Ser Lys Tyr Asn Ser His Ser Leu Glu Asn 
1               5                   10                  15      
Glu Ser Ile Lys Arg Thr Ser Arg Asp Gly Val Asn Arg Asp Leu Thr 
            20                  25                  30          
Glu Ala Val Pro Arg Leu Pro Gly Glu Thr Leu Ile Thr Asp Lys Glu 
        35                  40                  45              
Val Ile Tyr Ile Cys Pro Phe Asn Gly Pro Ile Lys Gly Arg Val Tyr 
    50                  55                  60                  
Ile Thr Asn Tyr Arg Leu Tyr Leu Arg Ser Leu Glu Thr Asp Ser Ser 
65                  70                  75                  80  
Leu Ile Leu Asp Val Pro Leu Gly Val Ile Ser Arg Ile Glu Lys Met 
                85                  90                  95      
Gly Gly Ala Thr Ser Arg Gly Glu Asn Ser Tyr Gly Leu Asp Ile Thr 
            100                 105                 110         
Cys Lys Asp Met Arg Asn Leu Arg Phe Ala Leu Lys Gln Glu Gly His 
        115                 120                 125             
Ser Arg Arg Asp Met Phe Glu Ile Leu Thr Arg Tyr Ala Phe Pro Leu 
    130                 135                 140                 
Ala His Ser Leu Pro Leu Phe Ala Phe Leu Asn Glu Glu Lys Phe Asn 
145                 150                 155                 160 
Val Asp Gly Trp Thr Val Tyr Asn Pro Val Glu Glu Tyr Arg Arg Gln 
                165                 170                 175     
Gly Leu Pro Asn His His Trp Arg Ile Thr Phe Ile Asn Lys Cys Tyr 
            180                 185                 190         
Glu Leu Cys Asp Thr Tyr Pro Ala Leu Leu Val Val Pro Tyr Arg Ala 
        195                 200                 205             
Ser Asp Asp Asp Leu Arg Arg Val Ala Thr Phe Arg Ser Arg Asn Arg 
    210                 215                 220                 
Ile Pro Val Leu Ser Trp Ile His Pro Glu Asn Lys Thr Val Ile Val 
225                 230                 235                 240 
Arg Cys Ser Gln Pro Leu Val Gly Met Ser Gly Lys Arg Asn Lys Asp 
                245                 250                 255     
Asp Glu Lys Tyr Leu Asp Val Ile Arg Glu Thr Asn Lys Gln Ile Ser 
            260                 265                 270         
Lys Leu Thr Ile Tyr Asp Ala Arg Pro Ser Val Asn Ala Val Ala Asn 
        275                 280                 285             
Lys Ala Thr Gly Gly Gly Tyr Glu Ser Asp Asp Ala Tyr His Asn Ala 
    290                 295                 300                 
Glu Leu Phe Phe Leu Asp Ile His Asn Ile His Val Met Arg Glu Ser 
305                 310                 315                 320 
Leu Lys Lys Val Lys Asp Ile Val Tyr Pro Asn Val Glu Glu Ser His 
                325                 330                 335     
Trp Leu Ser Ser Leu Glu Ser Thr His Trp Leu Glu His Ile Lys Leu 
            340                 345                 350         
Val Leu Thr Gly Ala Ile Gln Val Ala Asp Lys Val Ser Ser Gly Lys 
        355                 360                 365             
Ser Ser Val Leu Val His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln 
    370                 375                 380                 
Leu Thr Ser Leu Ala Met Leu Met Leu Asp Ser Phe Tyr Arg Ser Ile 
385                 390                 395                 400 
Glu Gly Phe Glu Ile Leu Val Gln Lys Glu Trp Ile Ser Phe Gly His 
                405                 410                 415     
Lys Phe Ala Ser Arg Ile Gly His Gly Asp Lys Asn His Thr Asp Ala 
            420                 425                 430         
Asp Arg Ser Pro Ile Phe Leu Gln Phe Ile Asp Cys Val Trp Gln Met 
        435                 440                 445             
Ser Lys Gln Phe Pro Thr Ala Phe Glu Phe Asn Glu Gln Phe Leu Ile 
    450                 455                 460                 
Ile Ile Leu Asp His Leu Tyr Ser Cys Arg Phe Gly Thr Phe Leu Phe 
465                 470                 475                 480 
Asn Cys Glu Ser Ala Arg Glu Arg Gln Lys Val Thr Glu Arg Thr Val 
                485                 490                 495     
Ser Leu Trp Ser Leu Ile Asn Ser Asn Lys Glu Lys Phe Lys Asn Pro 
            500                 505                 510         
Phe Tyr Thr Lys Glu Ile Asn Arg Val Leu Tyr Pro Val Ala Ser Met 
        515                 520                 525             
Arg His Leu Glu Leu Trp Val Asn Tyr Tyr Ile Arg Trp Asn Pro Arg 
    530                 535                 540                 
Ile Lys Gln Gln Gln Pro Asn Pro Val Glu Gln Arg Tyr Met Glu Leu 
545                 550                 555                 560 
Leu Ala Leu Arg Asp Glu Tyr Ile Lys Arg Leu Glu Glu Leu Gln Leu 
                565                 570                 575     
Ala Asn Ser Ala Lys Leu Ser Asp Pro Pro Thr Ser Pro Ser Ser Pro 
            580                 585                 590         
Ser Gln Met Met Pro His Val Gln Thr His Phe 
        595                 600             

<210> 2
<211> 603
<212> PRT
<213> Mus musculus

<220> 
<223> N° Accession NCBI: AAC77821.1

<400> 2
Met Ala Ser Ala Ser Ala Ser Lys Tyr Asn Ser His Ser Leu Glu Asn 
1               5                   10                  15      
Glu Ser Ile Lys Lys Val Ser Gln Asp Gly Val Ser Gln Asp Val Ser 
            20                  25                  30          
Glu Thr Val Pro Arg Leu Pro Gly Glu Leu Leu Ile Thr Glu Lys Glu 
        35                  40                  45              
Val Ile Tyr Ile Cys Pro Phe Asn Gly Pro Ile Lys Gly Arg Val Tyr 
    50                  55                  60                  
Ile Thr Asn Tyr Arg Leu Tyr Leu Arg Ser Leu Glu Thr Asp Ser Ala 
65                  70                  75                  80  
Leu Ile Leu Asp Val Pro Leu Gly Val Ile Ser Arg Ile Glu Tyr Met 
                85                  90                  95      
Gly Gly Ala Thr Ser Arg Gly Glu Asn Ser Tyr Gly Leu Asp Ile Thr 
            100                 105                 110         
Cys Lys Asp Leu Arg Asn Leu Arg Phe Ala Leu Lys Gln Glu Gly His 
        115                 120                 125             
Ser Arg Arg Asp Met Phe Glu Ile Leu Val Lys His Ala Phe Pro Leu 
    130                 135                 140                 
Ala His Asn Leu Pro Leu Phe Ala Phe Val Asn Glu Glu Lys Phe Asn 
145                 150                 155                 160 
Val Asp Gly Trp Thr Val Tyr Asn Pro Val Glu Glu Tyr Arg Arg Gln 
                165                 170                 175     
Gly Leu Pro Asn His His Trp Arg Ile Ser Phe Ile Asn Lys Cys Tyr 
            180                 185                 190         
Glu Leu Cys Glu Thr Tyr Pro Ala Leu Leu Val Val Pro Tyr Arg Thr 
        195                 200                 205             
Ser Asp Asp Asp Leu Arg Arg Ile Ala Thr Phe Arg Ser Arg Asn Arg 
    210                 215                 220                 
Leu Pro Val Leu Ser Trp Ile His Pro Glu Asn Lys Met Val Ile Met 
225                 230                 235                 240 
Arg Cys Ser Gln Pro Leu Val Gly Met Ser Gly Lys Arg Asn Lys Asp 
                245                 250                 255     
Asp Glu Lys Tyr Leu Asp Val Ile Arg Glu Thr Asn Lys Gln Thr Ser 
            260                 265                 270         
Lys Leu Met Ile Tyr Asp Ala Arg Pro Ser Val Asn Ala Val Ala Asn 
        275                 280                 285             
Lys Ala Thr Gly Gly Gly Tyr Glu Ser Asp Asp Ala Tyr Gln Asn Ser 
    290                 295                 300                 
Glu Leu Ser Phe Leu Asp Ile His Asn Ile His Val Met Arg Glu Ser 
305                 310                 315                 320 
Leu Lys Lys Val Lys Asp Ile Val Tyr Pro Asn Ile Glu Glu Ser His 
                325                 330                 335     
Trp Leu Ser Ser Leu Glu Ser Thr His Trp Leu Glu His Ile Lys Leu 
            340                 345                 350         
Val Leu Thr Gly Ala Ile Gln Val Ala Asp Gln Val Ser Ser Gly Lys 
        355                 360                 365             
Ser Ser Val Leu Val His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln 
    370                 375                 380                 
Leu Thr Ser Leu Ala Met Leu Met Leu Asp Ser Phe Tyr Arg Thr Ile 
385                 390                 395                 400 
Glu Gly Phe Glu Ile Leu Val Gln Lys Glu Trp Ile Ser Phe Gly His 
                405                 410                 415     
Lys Phe Ala Ser Arg Ile Gly His Gly Asp Lys Asn His Ala Asp Ala 
            420                 425                 430         
Asp Arg Ser Pro Ile Phe Leu Gln Phe Ile Asp Cys Val Trp Gln Met 
        435                 440                 445             
Ser Lys Gln Phe Pro Thr Ala Phe Glu Phe Asn Glu Gly Phe Leu Ile 
    450                 455                 460                 
Thr Val Leu Asp His Leu Tyr Ser Cys Arg Phe Gly Thr Phe Leu Phe 
465                 470                 475                 480 
Asn Cys Asp Ser Ala Arg Glu Arg Gln Lys Leu Thr Glu Arg Thr Val 
                485                 490                 495     
Ser Leu Trp Ser Leu Ile Asn Ser Asn Lys Asp Lys Phe Lys Asn Pro 
            500                 505                 510         
Phe Tyr Thr Lys Glu Ile Asn Arg Val Leu Tyr Pro Val Ala Ser Met 
        515                 520                 525             
Arg His Leu Glu Leu Trp Val Asn Tyr Tyr Ile Arg Trp Asn Pro Arg 
    530                 535                 540                 
Val Lys Gln Gln Gln Pro Asn Pro Val Glu Gln Arg Tyr Met Glu Leu 
545                 550                 555                 560 
Leu Ala Leu Arg Asp Asp Tyr Ile Lys Arg Leu Glu Glu Leu Gln Leu 
                565                 570                 575     
Ala Asn Ser Ala Lys Leu Ala Asp Ala Pro Ala Ser Thr Ser Ser Ser 
            580                 585                 590         
Ser Gln Met Val Pro His Val Gln Thr His Phe 
        595                 600             

<210> 3
<211> 603
<212> PRT
<213> Canis lupus

<220> 
<223> N° Accession NCBI : XP_855209.1

<400> 3
Met Ala Ser Ala Pro Thr Ser Lys Tyr Asn Ser His Ser Leu Glu Asn 
1               5                   10                  15      
Glu Ser Ile Lys Arg Thr Ser Arg Asp Gly Val Asn Trp Asp Leu Ser 
            20                  25                  30          
Glu Ala Val Pro Arg Leu Pro Gly Glu Thr Arg Ile Thr Asp Lys Glu 
        35                  40                  45              
Val Ile Tyr Ile Cys Pro Phe Asn Gly Pro Ile Lys Gly Arg Val Tyr 
    50                  55                  60                  
Ile Thr Asn Tyr Arg Leu Tyr Leu Arg Ser Leu Glu Thr Asp Ser Ala 
65                  70                  75                  80  
Leu Ile Leu Asp Val Pro Leu Gly Val Ile Ser Arg Ile Glu Lys Met 
                85                  90                  95      
Gly Gly Ala Thr Ser Arg Gly Glu Asn Ser Tyr Gly Leu Asp Ile Thr 
            100                 105                 110         
Cys Lys Asp Met Arg Asn Leu Arg Phe Ala Leu Lys Gln Glu Gly His 
        115                 120                 125             
Ser Arg Arg Asp Met Phe Glu Ile Leu Thr Arg Tyr Ala Phe Pro Leu 
    130                 135                 140                 
Ala His Ser Leu Pro Ile Phe Ala Phe Leu Asn Glu Glu Lys Phe Asn 
145                 150                 155                 160 
Val Asp Gly Trp Thr Val Tyr Asn Pro Val Glu Glu Tyr Arg Arg Gln 
                165                 170                 175     
Gly Leu Pro Asn His His Trp Arg Ile Thr Phe Ile Asn Lys Cys Tyr 
            180                 185                 190         
Glu Leu Cys Asp Thr Tyr Pro Ala Leu Leu Val Val Pro Tyr Arg Ala 
        195                 200                 205             
Ser Asp Asp Asp Leu Arg Arg Val Ala Thr Phe Arg Ser Arg Asn Arg 
    210                 215                 220                 
Ile Pro Val Leu Ser Trp Ile His Pro Glu Asn Lys Thr Val Ile Val 
225                 230                 235                 240 
Arg Cys Ser Gln Pro Leu Val Gly Met Ser Gly Lys Arg Asn Lys Asp 
                245                 250                 255     
Asp Glu Lys Tyr Leu Asp Val Ile Arg Glu Thr Asn Arg Gln Ile Ser 
            260                 265                 270         
Lys Leu Thr Ile Tyr Asp Ala Arg Pro Asn Val Asn Ala Val Ala Asn 
        275                 280                 285             
Lys Ala Thr Gly Gly Gly Tyr Glu Ser Asp Asp Ala Tyr His Asn Ala 
    290                 295                 300                 
Glu Leu Phe Phe Leu Asp Ile His Asn Ile His Val Met Arg Glu Ser 
305                 310                 315                 320 
Leu Lys Lys Val Lys Asp Ile Val Tyr Pro Asn Val Glu Glu Ser His 
                325                 330                 335     
Trp Leu Ser Ser Leu Glu Ser Thr His Trp Leu Glu His Ile Lys Leu 
            340                 345                 350         
Val Leu Thr Gly Ala Ile Gln Val Ala Asp Arg Val Ser Ser Gly Lys 
        355                 360                 365             
Ser Ser Val Leu Val His Cys Ser Asp Gly Trp Asp Arg Thr Ala Gln 
    370                 375                 380                 
Leu Thr Ser Leu Ala Met Leu Met Leu Asp Ser Phe Tyr Arg Ser Ile 
385                 390                 395                 400 
Glu Gly Phe Glu Ile Leu Val Gln Lys Glu Trp Ile Ser Phe Gly His 
                405                 410                 415     
Lys Phe Ala Ser Arg Ile Gly His Gly Asp Lys Asn His Ala Asp Ala 
            420                 425                 430         
Asp Arg Ser Pro Ile Phe Leu Gln Phe Ile Asp Cys Val Trp Gln Met 
        435                 440                 445             
Ser Lys Gln Phe Pro Thr Ala Phe Glu Phe Asn Glu Arg Phe Leu Ile 
    450                 455                 460                 
Thr Ile Leu Asp His Leu Tyr Ser Cys Arg Phe Gly Thr Phe Leu Tyr 
465                 470                 475                 480 
Asn Cys Glu Ser Ala Arg Glu Lys Gln Lys Val Thr Glu Arg Thr Val 
                485                 490                 495     
Ser Leu Trp Ser Leu Ile Asn Ser Asn Lys Asp Lys Phe Lys Asn Pro 
            500                 505                 510         
Phe Tyr Thr Lys Glu Ile Asn Arg Val Leu Tyr Pro Val Ala Ser Met 
        515                 520                 525             
Arg His Leu Glu Leu Trp Val Asn Tyr Tyr Ile Arg Trp Asn Pro Arg 
    530                 535                 540                 
Ile Lys Gln Gln Gln Pro Asn Pro Val Glu Gln Arg Tyr Val Glu Leu 
545                 550                 555                 560 
Leu Ala Leu Arg Asp Glu Tyr Ile Gln Arg Leu Glu Glu Leu Gln Leu 
                565                 570                 575     
Ala Ser Ser Ala Lys Leu Pro Asp Pro Ser Thr Ser Pro Ala Gly Pro 
            580                 585                 590         
Ser Gln Met Met Pro His Val Arg Thr His Phe 
        595                 600             

<210> 4
<211> 3452
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3452
<223> /mol_type="unassigned DNA"
      /note="N° Accession NCBI : NM_000252.2"
      /organism="Homo sapiens"

<400> 4
agagggggcg gagcagggcc cggcagccga gcagcctggc aacggcggtg gcgcccggag       60

cccgagagtt tccaggatgg cttctgcatc aacttctaaa tataattcac actccttgga      120

gaatgagtct attaagagga cgtctcgaga tggagtcaat cgagatctca ctgaggctgt      180

tcctcgactt ccaggagaaa cactaatcac tgacaaagaa gttatttaca tatgtccttt      240

caatggcccc attaagggaa gagtttacat cacaaattat cgtctttatt taagaagttt      300

ggaaacggat tcttctctaa tacttgatgt tcctctgggt gtgatctcga gaattgaaaa      360

aatgggaggc gcgacaagta gaggagaaaa ttcctatggt ctagatatta cttgtaaaga      420

catgagaaac ctgaggttcg ctttgaaaca ggaaggccac agcagaagag atatgtttga      480

gatcctcacg agatacgcgt ttcccctggc tcacagtctg ccattatttg catttttaaa      540

tgaagaaaag tttaacgtgg atggatggac agtttacaat ccagtggaag aatacaggag      600

gcagggcttg cccaatcacc attggagaat aacttttatt aataagtgct atgagctctg      660

tgacacttac cctgctcttt tggtggttcc gtatcgtgcc tcagatgatg acctccggag      720

agttgcaact tttaggtccc gaaatcgaat tccagtgctg tcatggattc atccagaaaa      780

taagacggtc attgtgcgtt gcagtcagcc tcttgtcggt atgagtggga aacgaaataa      840

agatgatgag aaatatctcg atgttatcag ggagactaat aaacaaattt ctaaactcac      900

catttatgat gcaagaccca gcgtaaatgc agtggccaac aaggcaacag gaggaggata      960

tgaaagtgat gatgcatatc ataacgccga acttttcttc ttagacattc ataatattca     1020

tgttatgcgg gaatctttaa aaaaagtgaa ggacattgtt tatcctaatg tagaagaatc     1080

tcattggttg tccagtttgg agtctactca ttggttagaa catatcaagc tcgttttgac     1140

aggagccatt caagtagcag acaaagtttc ttcagggaag agttcagtgc ttgtgcattg     1200

cagtgacgga tgggacagga ctgctcagct gacatccttg gccatgctga tgttggatag     1260

cttctatagg agcattgaag ggttcgaaat actggtacaa aaagaatgga taagttttgg     1320

acataaattt gcatctcgaa taggtcatgg tgataaaaac cacaccgatg ctgaccgttc     1380

tcctattttt ctccagttta ttgattgtgt gtggcaaatg tcaaaacagt tccctacagc     1440

ttttgaattc aatgaacaat ttttgattat aattttggat catctgtata gttgccgatt     1500

tggtactttc ttattcaact gtgaatctgc tcgagaaaga cagaaggtta cagaaaggac     1560

tgtttcttta tggtcactga taaacagtaa taaagaaaaa ttcaaaaacc ccttctatac     1620

taaagaaatc aatcgagttt tatatccagt tgccagtatg cgtcacttgg aactctgggt     1680

gaattactac attagatgga accccaggat caagcaacaa cagccgaatc cagtggagca     1740

gcgttacatg gagctcttag ccttacgcga cgaatacata aagcggcttg aggaactgca     1800

gctcgccaac tctgccaagc tttctgatcc cccaacttca ccttccagtc cttcgcaaat     1860

gatgccccat gtgcaaactc acttctgagg ggggaccctg gcaccgcatt agagctcgaa     1920

ataaaggcga tagctgactt tcatttgggg catttgtaaa aagtagatta aaatatttgc     1980

ctccatgtag aacttgaact aacataatct taaactcttg aatatgtgcc ttctagaata     2040

catattacaa gaaaactaca gggtccacac ggcaatcaga agaaaggagc tgagatgagg     2100

ttttggaaaa ccctgacacc tttaaaaagc agtttttgaa agacaaaatt tagatttaat     2160

ttacgtcttg agaaatacta tatatacaat atatattttg tgggcttaat tgaaacaaca     2220

ttattttaaa atcaaagggg atatatgttt gtggaatgga ttttcctgaa gctgcttaac     2280

agttgctttg gattctctaa gatgaatcca aatgtgaaag atgcatgtta ctgccaaaac     2340

caaattgagc tcagcttcct aggcattacc caaaagcaag gtgtttaagt aattgccagc     2400

ttttatacca tcatgagtgg tgacttaagg agaaatagct gtatagatga gtttttcatt     2460

atttggaaat ttaggggtag aaaatgtttt cccctaattt tccagagaag cctattttta     2520

tatttttaaa aaactgacag ggcccagtta aatatgattt gcatttttta aatttgccag     2580

ttttattttc taaattcttt catgagcttg cctaaaattc ggaatggttt tcgggttgtg     2640

gcaaacccca aagagagcac tgtccaagga tgtcgggagc atcctgctgc ttaggggaat     2700

gttttcgcaa atgttgctct agtcagtcca gctcatctgc caaaatgtag ggctaccgtc     2760

ttggatgcat gagctattgc tagagcatca tccttagaaa tcagtgcccc agatgtacat     2820

gtgttgagcg tattcttgaa agtattgtgt ttatgcattt caatttcaat ggtgttggct     2880

tcccctcccc accccacgcg tgcataaaaa ctggttctac aaatttttac ttgaagtacc     2940

aggccgtttg ctttttcagg ttgttttgtt ttatagtatt aagtgaaatt ttaaatgcac     3000

agttctattt gctatctgaa ctaattcatt tattaagtat atttgtaaaa gctaaggctc     3060

gagttaaaac aatgaagtgt tttacaatga tttgtaaagg actatttata actaatatgg     3120

ttttgttttc aatgaattaa gaaagattaa atatatcttt gtaaattatt ttatgtcata     3180

gtttaattgg tctaccaagt aagacatctc aaatacagta gtataatgta tgaattttgt     3240

aagtataaga aattttatta gacattctct tactttttgt aaatgctgta aatatttcat     3300

aaattaacaa agtgtcactc cataaaaaga aagctaatac taatagccta aaagattttg     3360

tgaaatttca tgaaaacttt ttaatggcaa taatgactaa agacctgctg taataaatgt     3420

attaactgaa acctaaaaaa aaaaaaaaaa aa                                   3452


<210> 5
<211> 3339
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..3339
<223> /mol_type="unassigned DNA"
      /note="N° Accession NCBI : AF_073996"
      /organism="Mus musculus"

<400> 5
cggtgagttc gctttcttgg ctgacctggc tcggagccgg gcattgcggg gatccaggat       60

tggaaaggtt ccaggatggc ttctgcatca gcatctaagt ataattcaca ctccttggag      120

aatgaatcca ttaagaaagt gtctcaagat ggagtcagtc aggatgtgag tgagactgtc      180

cctcggctcc caggggagtt actaattact gaaaaagaag ttatttacat atgtcctttc      240

aatggcccca ttaagggaag agtttacatc acaaattatc gtctttattt aagaagtttg      300

gaaacggatt ctgctctaat acttgatgtt cctctgggtg tgatatcaag aattgaatat      360

atgggaggcg cgactagtag aggagaaaat tcctatggtc tagatattac ttgtaaagat      420

ttgagaaacc tgaggtttgc attgaagcaa gaaggccaca gcagaagaga tatgtttgag      480

atccttgtaa aacatgcctt tcctctggca cacaatctgc cattatttgc atttgtaaat      540

gaagagaagt ttaacgtgga tgggtggact gtttataatc cagttgaaga atatagaagg      600

cagggcctgc ccaatcacca ttggaggata agttttatta acaagtgcta tgagctctgt      660

gagacatacc ctgctctttt ggtggttccc tatcggacct cagatgatga tcttaggagg      720

atcgcaacgt ttagatcccg aaatcggctt cctgtactgt cgtggattca cccagaaaac      780

aaaatggtca ttatgcgctg cagtcagcct cttgtcggta tgagtggtaa aagaaataaa      840

gatgacgaga aatacctgga tgtgatcagg gaaactaaca aacaaacttc taagctcatg      900

atttatgatg cacgacccag tgtaaatgca gtcgccaaca aggcaacagg aggaggatat      960

gaaagtgatg acgcatatca aaactcagaa ctttccttct tagacattca taatattcat     1020

gttatgcgag aatctttaaa aaaagtgaaa gatattgttt atcccaacat agaagaatct     1080

cattggttgt ccagtttgga gtctactcat tggttagaac atatcaagct tgttctgacc     1140

ggtgccattc aagtggcaga ccaagtgtct tcaggaaaga gctcggtact tgtgcactgc     1200

agtgacggat gggacaggac cgctcagctg acatccttgg ccatgctgat gttggacagc     1260

ttctacagaa ctattgaagg ctttgagata ttggtacaga aagagtggat aagttttggc     1320

cataaatttg catctagaat aggtcatggt gataaaaacc atgctgatgc tgatcgatct     1380

cctatttttc ttcagtttat tgactgtgtg tggcagatgt cgaaacagtt ccccacagct     1440

tttgagttca atgaaggctt tttgattacc gttttggatc atctgtatag ctgtcgattt     1500

ggtactttct tattcaactg tgactcggct cgagaaagac agaaacttac agaaagaaca     1560

gtttctctat ggtcgctaat taacagcaat aaagacaaat tcaaaaaccc cttctataca     1620

aaagaaatca atcgggtttt gtatccagtt gccagcatgc gtcacttgga actgtgggtg     1680

aattattaca tccgatggaa tcccagggtc aagcagcaac agcccaaccc agtggagcag     1740

cgttacatgg agcttttggc cttgcgtgac gattatataa agaggctcga ggaattgcag     1800

ctggccaact ccgccaagct tgctgatgcc cccgcttcga cttccagttc gtcacagatg     1860

gtgccccatg tgcagacgca cttctgaggg gactcacttc tggcactgca cttgaactct     1920

agataagtga aatagctgac tctcattctg ggcatgtgga caaagtagat ttaaagtgtc     1980

tgcctccatt tagaagttca actaacatct tagacttttg agtatgtgcc ttctgtaata     2040

catatcacaa gaaatcgatg gtgtccgtgt ggcaatcata aggaaggagt caagaggggg     2100

ttctggaaaa tcctcatact tttttttaca aagcactttt gcaaagataa aacttaaatt     2160

taatttacct ctatataaat tctacatata cagtatgtat tttgtgggct taattgaaat     2220

attattttaa atccaggggg gagatttgtt tgcaaaatgt attttcctcc agctgcttat     2280

aacagttgct ttggattatc taaaattaat ccaaatgtga aagatgggta ttactgccaa     2340

agccaaattg cactctgctt cttcagcaaa ttccaagagc aaggcgttta aataattgcc     2400

aatttttatt ttaccataag tggtaaggta aaaagaaaga tgaacatttc atcattttga     2460

atttttgaaa ataaaaggtt ctcccatcat ttttcaagag aagcacattt ttatattaag     2520

aaaaagtgat aaggtttgat ttttttttcc ctcaacattc tcagctttgc tttctaaatt     2580

atcccatgat ttttgtctaa cactgagtca tactcaggtt gaaggaaacc cataaatagc     2640

actgtgcgag gagctggctg gcttctgctg cttagaggaa tatgttcgca aacatgcctc     2700

tagtcaattc gccttatctg ctgaagtgta ggggcaccgc cttgaatgga tgagctatgg     2760

ctagagcatc tttctttaca gtaatgcccc aggtgtattc tgtttatgtc tctctgttta     2820

aatggtgtgc gtgcataaaa acttgctctg cacattatta cttgaagtac tgggcaattt     2880

gctttttcag gttttttttc attttgtttt gtagtatgaa atggaatttt aaatgcacag     2940

ttctatttga tatccgaact aattcattta gtaaatatat ttgtaaaagc taaagttaaa     3000

tcaattaatg ttttacagtg atttgtaaag gattatttat agctaatatg gttttgtttt     3060

cagtgaatta agagagatta catttatctt tgtaaattat tttatgtcat agcttaatgg     3120

cctaccaaat gagacatctc aaatataata gtataatgta tggattttgt aagtataaaa     3180

attattagat attcgtttgc tttttgtaaa cactgtaaat atttcataaa ttaaaatgtg     3240

tcactccata agaagaaaaa actaatacta atagttgaca ggaattggtg aaatttcatg     3300

aaaatatttt cattgcaata aatattaaaa gacctgctg                            3339


<210> 6
<211> 1841
<212> DNA
<213> Canis lupus

<220> 
<221> source
<222> 1..1841
<223> /mol_type="unassigned DNA"
      /note="N° Accession NCBI : XM_850116"
      /organism="Canis lupus"

<400> 6
cggtggcgcc cggaccccga gtttccagta tggcttctgc accaacttct aaatataatt      60

cacactcctt ggagaacgag tctattaaga ggacttctag ggatggagtt aattgggacc     120

tgagtgaggc tgttcctcga cttccaggag aaactcgtat cactgacaaa gaagttattt     180

acatatgtcc tttcaatggc cccattaagg gaagagttta catcacaaat tatcgtcttt     240

atttaagaag tttggaaacg gattctgctc taatacttga tgttcctctg ggtgtgatct     300

ccagaattga aaaaatggga ggcgcgacaa gtagaggaga aaattcgtat ggtctagata     360

ttacttgtaa agacatgagg aacttgaggt tcgcgctgaa acaggaaggc cacagcagga     420

gggatatgtt tgagatcctc acaagatacg cctttccctt ggcccacagt ctgccaatat     480

ttgcatttct aaacgaagaa aagtttaacg tggatgggtg gacagtttat aatccagtcg     540

aagaatacag aaggcagggc ttgcccaatc accactggag aataactttt atcaacaagt     600

gctatgagct ctgtgacact tatcctgctc tcttggtggt tccatatcgt gcctcagatg     660

acgatctcag gagagttgca acttttagat ccagaaatcg aattccagtg ctgtcatgga     720

ttcatccaga aaacaagacg gtcattgtgc gctgcagcca gcctcttgtc ggaatgagtg     780

gtaaacggaa taaagatgat gagaagtatc tcgatgttat cagggagact aacagacaaa     840

tttctaaact cacaatctat gatgccagac ccaatgtaaa tgccgtggcc aacaaggcaa     900

caggaggagg atatgaaagt gatgatgcat atcataacgc cgaacttttc ttcttagaca     960

ttcataacat tcatgttatg cgggaatctt taaaaaaagt caaagacatc gtttatccta    1020

atgtggaaga gtctcactgg ctgtccagtt tggagtctac ccattggtta gaacatatca    1080

agcttgtttt gacgggagcc attcaagtag cagacagagt ttcttcaggg aagagctcag    1140

tgctcgtgca ctgcagcgat ggatgggaca ggactgccca gctgacgtcc ttggccatgc    1200

tgatgctcga cagcttctat cggagcatcg agggctttga aatattggta caaaaggaat    1260

ggataagttt tggacataag tttgcatcta gaataggtca tggtgataaa aaccacgccg    1320

acgctgaccg gtctcctatt tttctccagt ttattgattg tgtatggcaa atgtcaaaac    1380

agttccctac agcttttgaa ttcaatgaac gatttttgat tacaattttg gatcatctgt    1440

atagttgccg gtttggtacc ttcttgtaca actgtgaatc tgctcgggaa aaacagaaag    1500

tgacggaacg aacagtatct ttatggtcac tgataaacag taataaggac aaattcaaaa    1560

atcccttcta tactaaagaa atcaatcgag ttttatatcc agttgccagt atgcgtcact    1620

tggaactttg ggtgaattac tacattagat ggaaccccag gatcaagcaa caacagccca    1680

acccagtgga gcagcggtac gtggagctgt tggccttgcg tgacgaatac atacagcggc    1740

tcgaggagct gcagctcgcc agctcggcca agctgcccga cccctcgacc tcaccggccg    1800

ggccctcgca gatgatgccg cacgtgcgca cacacttctg a                        1841


<210> 7
<211> 821
<212> PRT
<213> Homo sapiens

<220> 
<223> N° Accession NCBI: NP_000061.1

<400> 7
Met Pro Thr Val Ile Ser Ala Ser Val Ala Pro Arg Thr Ala Ala Glu 
1               5                   10                  15      
Pro Arg Ser Pro Gly Pro Val Pro His Pro Ala Gln Ser Lys Ala Thr 
            20                  25                  30          
Glu Ala Gly Gly Gly Asn Pro Ser Gly Ile Tyr Ser Ala Ile Ile Ser 
        35                  40                  45              
Arg Asn Phe Pro Ile Ile Gly Val Lys Glu Lys Thr Phe Glu Gln Leu 
    50                  55                  60                  
His Lys Lys Cys Leu Glu Lys Lys Val Leu Tyr Val Asp Pro Glu Phe 
65                  70                  75                  80  
Pro Pro Asp Glu Thr Ser Leu Phe Tyr Ser Gln Lys Phe Pro Ile Gln 
                85                  90                  95      
Phe Val Trp Lys Arg Pro Pro Glu Ile Cys Glu Asn Pro Arg Phe Ile 
            100                 105                 110         
Ile Asp Gly Ala Asn Arg Thr Asp Ile Cys Gln Gly Glu Leu Gly Asp 
        115                 120                 125             
Cys Trp Phe Leu Ala Ala Ile Ala Cys Leu Thr Leu Asn Gln His Leu 
    130                 135                 140                 
Leu Phe Arg Val Ile Pro His Asp Gln Ser Phe Ile Glu Asn Tyr Ala 
145                 150                 155                 160 
Gly Ile Phe His Phe Gln Phe Trp Arg Tyr Gly Glu Trp Val Asp Val 
                165                 170                 175     
Val Ile Asp Asp Cys Leu Pro Thr Tyr Asn Asn Gln Leu Val Phe Thr 
            180                 185                 190         
Lys Ser Asn His Arg Asn Glu Phe Trp Ser Ala Leu Leu Glu Lys Ala 
        195                 200                 205             
Tyr Ala Lys Leu His Gly Ser Tyr Glu Ala Leu Lys Gly Gly Asn Thr 
    210                 215                 220                 
Thr Glu Ala Met Glu Asp Phe Thr Gly Gly Val Ala Glu Phe Phe Glu 
225                 230                 235                 240 
Ile Arg Asp Ala Pro Ser Asp Met Tyr Lys Ile Met Lys Lys Ala Ile 
                245                 250                 255     
Glu Arg Gly Ser Leu Met Gly Cys Ser Ile Asp Asp Gly Thr Asn Met 
            260                 265                 270         
Thr Tyr Gly Thr Ser Pro Ser Gly Leu Asn Met Gly Glu Leu Ile Ala 
        275                 280                 285             
Arg Met Val Arg Asn Met Asp Asn Ser Leu Leu Gln Asp Ser Asp Leu 
    290                 295                 300                 
Asp Pro Arg Gly Ser Asp Glu Arg Pro Thr Arg Thr Ile Ile Pro Val 
305                 310                 315                 320 
Gln Tyr Glu Thr Arg Met Ala Cys Gly Leu Val Arg Gly His Ala Tyr 
                325                 330                 335     
Ser Val Thr Gly Leu Asp Glu Val Pro Phe Lys Gly Glu Lys Val Lys 
            340                 345                 350         
Leu Val Arg Leu Arg Asn Pro Trp Gly Gln Val Glu Trp Asn Gly Ser 
        355                 360                 365             
Trp Ser Asp Arg Trp Lys Asp Trp Ser Phe Val Asp Lys Asp Glu Lys 
    370                 375                 380                 
Ala Arg Leu Gln His Gln Val Thr Glu Asp Gly Glu Phe Trp Met Ser 
385                 390                 395                 400 
Tyr Glu Asp Phe Ile Tyr His Phe Thr Lys Leu Glu Ile Cys Asn Leu 
                405                 410                 415     
Thr Ala Asp Ala Leu Gln Ser Asp Lys Leu Gln Thr Trp Thr Val Ser 
            420                 425                 430         
Val Asn Glu Gly Arg Trp Val Arg Gly Cys Ser Ala Gly Gly Cys Arg 
        435                 440                 445             
Asn Phe Pro Asp Thr Phe Trp Thr Asn Pro Gln Tyr Arg Leu Lys Leu 
    450                 455                 460                 
Leu Glu Glu Asp Asp Asp Pro Asp Asp Ser Glu Val Ile Cys Ser Phe 
465                 470                 475                 480 
Leu Val Ala Leu Met Gln Lys Asn Arg Arg Lys Asp Arg Lys Leu Gly 
                485                 490                 495     
Ala Ser Leu Phe Thr Ile Gly Phe Ala Ile Tyr Glu Val Pro Lys Glu 
            500                 505                 510         
Met His Gly Asn Lys Gln His Leu Gln Lys Asp Phe Phe Leu Tyr Asn 
        515                 520                 525             
Ala Ser Lys Ala Arg Ser Lys Thr Tyr Ile Asn Met Arg Glu Val Ser 
    530                 535                 540                 
Gln Arg Phe Arg Leu Pro Pro Ser Glu Tyr Val Ile Val Pro Ser Thr 
545                 550                 555                 560 
Tyr Glu Pro His Gln Glu Gly Glu Phe Ile Leu Arg Val Phe Ser Glu 
                565                 570                 575     
Lys Arg Asn Leu Ser Glu Glu Val Glu Asn Thr Ile Ser Val Asp Arg 
            580                 585                 590         
Pro Val Lys Lys Lys Lys Thr Lys Pro Ile Ile Phe Val Ser Asp Arg 
        595                 600                 605             
Ala Asn Ser Asn Lys Glu Leu Gly Val Asp Gln Glu Ser Glu Glu Gly 
    610                 615                 620                 
Lys Gly Lys Thr Ser Pro Asp Lys Gln Lys Gln Ser Pro Gln Pro Gln 
625                 630                 635                 640 
Pro Gly Ser Ser Asp Gln Glu Ser Glu Glu Gln Gln Gln Phe Arg Asn 
                645                 650                 655     
Ile Phe Lys Gln Ile Ala Gly Asp Asp Met Glu Ile Cys Ala Asp Glu 
            660                 665                 670         
Leu Lys Lys Val Leu Asn Thr Val Val Asn Lys His Lys Asp Leu Lys 
        675                 680                 685             
Thr His Gly Phe Thr Leu Glu Ser Cys Arg Ser Met Ile Ala Leu Met 
    690                 695                 700                 
Asp Thr Asp Gly Ser Gly Lys Leu Asn Leu Gln Glu Phe His His Leu 
705                 710                 715                 720 
Trp Asn Lys Ile Lys Ala Trp Gln Lys Ile Phe Lys His Tyr Asp Thr 
                725                 730                 735     
Asp Gln Ser Gly Thr Ile Asn Ser Tyr Glu Met Arg Asn Ala Val Asn 
            740                 745                 750         
Asp Ala Gly Phe His Leu Asn Asn Gln Leu Tyr Asp Ile Ile Thr Met 
        755                 760                 765             
Arg Tyr Ala Asp Lys His Met Asn Ile Asp Phe Asp Ser Phe Ile Cys 
    770                 775                 780                 
Cys Phe Val Arg Leu Glu Gly Met Phe Arg Ala Phe His Ala Phe Asp 
785                 790                 795                 800 
Lys Asp Gly Asp Gly Ile Ile Lys Leu Asn Val Leu Glu Trp Leu Gln 
                805                 810                 815     
Leu Thr Met Tyr Ala 
            820     

<210> 8
<211> 3316
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3316
<223> /mol_type="unassigned DNA"
      /note="N° Accession NCBI: NM_000070 "
      /organism="Homo sapiens"

<400> 8
cactctcttt ctctctccct ctggcatgca tgctgctggt aggagacccc caagtcaaca       60

ttgcttcaga aatcctttag cactcatttc tcaggagaac ttatggcttc agaatcacag      120

ctcggttttt aagatggaca taacctgtac gaccttctga tgggctttca actttgaact      180

ggatgtggac acttttctct cagatgacag aattactcca acttcccctt tgcagttgct      240

tcctttcctt gaaggtagct gtatcttatt ttctttaaaa agctttttct tccaaagcca      300

cttgccatgc cgaccgtcat tagcgcatct gtggctccaa ggacagcggc tgagccccgg      360

tccccagggc cagttcctca cccggcccag agcaaggcca ctgaggctgg gggtggaaac      420

ccaagtggca tctattcagc catcatcagc cgcaattttc ctattatcgg agtgaaagag      480

aagacattcg agcaacttca caagaaatgt ctagaaaaga aagttcttta tgtggaccct      540

gagttcccac cggatgagac ctctctcttt tatagccaga agttccccat ccagttcgtc      600

tggaagagac ctccggaaat ttgcgagaat ccccgattta tcattgatgg agccaacaga      660

actgacatct gtcaaggaga gctaggggac tgctggtttc tcgcagccat tgcctgcctg      720

accctgaacc agcaccttct tttccgagtc ataccccatg atcaaagttt catcgaaaac      780

tacgcaggga tcttccactt ccagttctgg cgctatggag agtgggtgga cgtggttata      840

gatgactgcc tgccaacgta caacaatcaa ctggttttca ccaagtccaa ccaccgcaat      900

gagttctgga gtgctctgct ggagaaggct tatgctaagc tccatggttc ctacgaagct      960

ctgaaaggtg ggaacaccac agaggccatg gaggacttca caggaggggt ggcagagttt     1020

tttgagatca gggatgctcc tagtgacatg tacaagatca tgaagaaagc catcgagaga     1080

ggctccctca tgggctgctc cattgatgat ggcacgaaca tgacctatgg aacctctcct     1140

tctggtctga acatggggga gttgattgca cggatggtaa ggaatatgga taactcactg     1200

ctccaggact cagacctcga ccccagaggc tcagatgaaa gaccgacccg gacaatcatt     1260

ccggttcagt atgagacaag aatggcctgc gggctggtca gaggtcacgc ctactctgtc     1320

acggggctgg atgaggtccc gttcaaaggt gagaaagtga agctggtgcg gctgcggaat     1380

ccgtggggcc aggtggagtg gaacggttct tggagtgata gatggaagga ctggagcttt     1440

gtggacaaag atgagaaggc ccgtctgcag caccaggtca ctgaggatgg agagttctgg     1500

atgtcctatg aggatttcat ctaccatttc acaaagttgg agatctgcaa cctcacggcc     1560

gatgctctgc agtctgacaa gcttcagacc tggacagtgt ctgtgaacga gggccgctgg     1620

gtacggggtt gctctgccgg aggctgccgc aacttcccag atactttctg gaccaaccct     1680

cagtaccgtc tgaagctcct ggaggaggac gatgaccctg atgactcgga ggtgatttgc     1740

agcttcctgg tggccctgat gcagaagaac cggcggaagg accggaagct aggggccagt     1800

ctcttcacca ttggcttcgc catctacgag gttcccaaag agatgcacgg gaacaagcag     1860

cacctgcaga aggacttctt cctgtacaac gcctccaagg ccaggagcaa aacctacatc     1920

aacatgcggg aggtgtccca gcgcttccgc ctgcctccca gcgagtacgt catcgtgccc     1980

tccacctacg agccccacca ggagggggaa ttcatcctcc gggtcttctc tgaaaagagg     2040

aacctctctg aggaagttga aaataccatc tccgtggatc ggccagtgaa aaagaaaaaa     2100

accaagccca tcatcttcgt ttcggacaga gcaaacagca acaaggagct gggtgtggac     2160

caggagtcag aggagggcaa aggcaaaaca agccctgata agcaaaagca gtccccacag     2220

ccacagcctg gcagctctga tcaggaaagt gaggaacagc aacaattccg gaacattttc     2280

aagcagatag caggagatga catggagatc tgtgcagatg agctcaagaa ggtccttaac     2340

acagtcgtga acaaacacaa ggacctgaag acacacgggt tcacactgga gtcctgccgt     2400

agcatgattg cgctcatgga tacagatggc tctggaaagc tcaacctgca ggagttccac     2460

cacctctgga acaagattaa ggcctggcag aaaattttca aacactatga cacagaccag     2520

tccggcacca tcaacagcta cgagatgcga aatgcagtca acgacgcagg attccacctc     2580

aacaaccagc tctatgacat cattaccatg cggtacgcag acaaacacat gaacatcgac     2640

tttgacagtt tcatctgctg cttcgttagg ctggagggca tgttcagagc ttttcatgca     2700

tttgacaagg atggagatgg tatcatcaag ctcaacgttc tggagtggct gcagctcacc     2760

atgtatgcct gaaccaggct ggcctcatcc aaagccatgc aggatcactc aggatttcag     2820

tttcaccctc tatttccaaa gccatttacc tcaaaggacc cagcagctac acccctacag     2880

gcttccaggc acctcatcag tcatgctcct cctccatttt accccctacc catccttgat     2940

cggtcatgcc tagcctgacc ctttagtaaa gcaatgaggt aggaagaaca aacccttgtc     3000

cctttgccat gtggaggaaa gtgcctgcct ctggtccgag ccgcctcggt tctgaagcga     3060

gtgctcctgc ttaccttgct ctaggctgtc tgcagaagca cctgccggtg gcactcagca     3120

cctccttgtg ctagagccct ccatcacctt cacgctgtcc caccatgggc caggaaccaa     3180

accagcactg ggttctactg ctgtggggta aactaactca gtggaatagg gctggttact     3240

ttgggctgtc caactcataa gtttggctgc attttgaaaa aagctgatct aaataaaggc     3300

atgtgtatgg ctggtc                                                     3316


<210> 9
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /mol_type="other RNA"
      /note="N°Accession: MIMT0000241"
      /organism="Homo sapiens"

<400> 9
auaagacgag caaaaagcuu gu                                             22


<210> 10
<211> 22
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 10
acaagctttt tgctcgtctt at                                             22


<210> 11
<211> 1050
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1050
<223> /mol_type="unassigned DNA"
      /note="Promoteur Desmine"
      /organism="Homo sapiens"

<400> 11
cccccacagc tcctctcctg tgccttgttt cccagccatg cgttctcctc tataaatacc      60

cgctctggta tttggggttg gcagctgttg ctgccaggga gatggttggg ttgacatgcg     120

gctcctgaca aaacacaaac ccctggtgtg tgtgggcgtg ggtggtgtga gtagggggat     180

gaatcaggga gggggcgggg gacccagggg gcaggagcca cacaaagtct gtgcgggggt     240

gggagcgcac atagcaattg gaaactgaaa gcttatcaga ccctttctgg aaatcagccc     300

actgtttata aacttgaggc cccaccctcg acagtaccgg ggaggaagag ggcctgcact     360

agtccagagg gaaactgagg ctcagggcca gctcgcccat agacatacat ggcaggcagg     420

ctttggccag gatccctccg cctgccaggc gtctccctgc cctcccttcc tgcctagaga     480

cccccaccct caagcctggc tggtctttgc ctgagaccca aacctcttcg acttcaagag     540

aatatttagg aacaaggtgg tttagggcct ttcctgggaa caggccttga ccctttaaga     600

aatgacccaa agtctctcct tgaccaaaaa ggggaccctc aaactaaagg gaagcctctc     660

ttctgctgtc tcccctgacc ccactccccc ccaccccagg acgaggagat aaccagggct     720

gaaagaggcc cgcctggggg ctgcagacat gcttgctgcc tgccctggcg aaggattggt     780

aggcttgccc gtcacaggac ccccgctggc tgactcaggg gcgcaggcct cttgcggggg     840

agctggcctc cccgccccca cggccacggg ccgccctttc ctggcaggac agcgggatct     900

tgcagctgtc aggggagggg aggcgggggc tgatgtcagg agggatacaa atagtgccga     960

cggctggggg ccctgtctcc cctcgccgca tccactctcc ggccggccgc ctgcccgccg    1020

cctcctccgt gcgcccgcca gcctcgcccg                                     1050


<210> 12
<211> 1654
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1654
<223> /mol_type="unassigned DNA"
      /note="Promoteur calpaine 3"
      /organism="Homo sapiens"

<400> 12
cacatgcctc cactctgcca tacttgaaat gtgctcatct ccttacagcc cagggagcag      60

ctattgtggg tagaagacaa ggtggaggcc aggcaggcac ttcccttccc cagagccact     120

tatgctctca tctaagagcc ctgaaaccag gtgtgacatc ccaggagttg acagacagtc     180

tggttcagta tctaattcca acttctgtct cagatgccta atgtggcatg gctgaatgag     240

tcaacatata acctgtacag taagtcctca cttaacatca ttgataggtg cttgtaaact     300

gtgactttaa cgaaaacata ccgtgtgctg tagggactta actcttgttt atatcagtta     360

gcctggtttc actatacagt acatcatttt gcttaaagtc acagcttacg agaacctatc     420

gatgatgtta agtgaggatt ttctctgctc aggtgcactt tttttttttt tttaagacgg     480

agtctctttc tgtcacctgg gctggagtgc agtggcgcga tctgggttca ctacaacctc     540

tgcctcctgg gttcaagcaa ttcttctgtc tcagcctccc aagtagctgg gattacaggc     600

acccgccgcc acacccggct tatttttgta tttttagtag agacagggtt tcactattgt     660

tggccatgct ggtctcgaac tcctgacctc atgtgatcca cccgcctcgg cctcccaaag     720

tgcagagatt agagacgtga gccacatggc ccagcaggac cactttttag cagattcagt     780

cccagtgttc attttgtgga tggggagaga caagaggtgg caaggtcaag tgtgcaggta     840

gagacaggga ttttctcaaa tgaggactct gctgagtagc attttccatg cagacatttc     900

caatgagcgc tgacccaaga acattctaaa aaagatacca aatctaacat tgaataatgt     960

tctgatatcc taaaatttta ggactaaaaa tcatgttctc taaaattcac agaatatttt    1020

tgtagaattc agtacctccc gttcacccta actagctttt ttgcaatatt gttttccatt    1080

catttgatgg ccagtagttg ggtggtctgt ataactgcct actcaataac atgtcagcag    1140

ttctcagctt ctttccagtg ttcaccttac tcagatactc ccttttcatt ttctggcaac    1200

accagcactt catggcaaca gaaatgtccc tagccaggtt ctctctctac catgcagtct    1260

ctcttgctct catactcaca gtgtttcttc acatctattt ttagttttcc tggctcaagc    1320

atcttcaggc cactgaaaca caaccctcac tctctttctc tctccctctg gcatgcatgc    1380

tgctggtagg agacccccaa gtcaacattg cttcagaaat cctttagcac tcatttctca    1440

ggagaactta tggcttcaga atcacagctc ggtttttaag atggacataa cctgtacgac    1500

cttctgatgg gctttcaact ttgaactgga tgtggacact tttctctcag atgacagaat    1560

tactccaact tcccctttgc agttgcttcc tttccttgaa ggtagctgta tcttattttc    1620

tttaaaaagc tttttcttcc aaagccactt gcca                                1654


<210> 13
<211> 805
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..805
<223> /mol_type="unassigned DNA"
      /note="promoteur miARN206"
      /organism="Homo sapiens"

<400> 13
gggggccaac tcttcctttg gcatatgttt ccccattttc tggcagagaa tcagatacca      60

caaagttcaa aaccccatct ccctccagcc agggtggcca tccagaccct gagtggctca     120

acagctgcca atgtccctca tccttctgag gctcaggcct cacagattgt ggggcaggtg     180

atgggctagg gggagcagaa gcccgacaaa aggatccttc ccacagtgaa caatggtgct     240

tggaatgctg gatgggcagc tgctgcccat caacaagcac ccaaaacaga tagacgtaca     300

gtaggaagta caggagggcc ggtgtgtttc taagcatgag tggctctctg cgtgaatgtg     360

gaaaatttct ctgttggatt ctctcttctt tttaattttc ccttcactgg atcccaaaca     420

ttaaaaaaga atcacattca aaatgcacaa aaacagcagc agtgaattaa ttagtagtaa     480

taacaaagga ctggatagac tgtagctgca caagaataag ccagggaaac gtggtgctgc     540

ttatctgtga acaaacagta ggaaggattt ggtcccaagc agcactgcca ttcctcacaa     600

cagatttatt tcagcatgat ttggtcgggc gggggggatt taggatgagt tgagatccca     660

gtgatcttct cgctaagagt ttcctgcctg ggcaaggagg aaagatgcta caagtggccc     720

acttctgaga tgcgggctgc ttctggatga cactgcttcc cgaggccaca tgcttcttta     780

tatccccata tggattactt tgcta                                           805


<210> 14
<211> 1812
<212> DNA
<213> Mus musculus

<220> 
<221> source
<222> 1..1812
<223> /mol_type="unassigned DNA"
      /note="ORF MTM1"
      /organism="Mus musculus"

<400> 14
atggcttctg catcagcatc taagtataat tcacactcct tggagaatga atccattaag      60

aaagtgtctc aagatggagt cagtcaggat gtgagtgaga ctgtccctcg gctcccaggg     120

gagttactaa ttactgaaaa agaagttatt tacatatgtc ctttcaatgg ccccattaag     180

ggaagagttt acatcacaaa ttatcgtctt tatttaagaa gtttggaaac ggattctgct     240

ctaatacttg atgttcctct gggtgtgata tcaagaattg aaaaaatggg aggcgcgaca     300

agtagaggag aaaattccta tggtctagat attacttgta aagatttgag aaacctgagg     360

tttgcattga agcaagaagg ccacagcaga agagatatgt ttgagatcct tgtaaaacat     420

gcctttcctc tggcacacaa tctgccatta tttgcatttg taaatgaaga gaagtttaac     480

gtggatgggt ggactgttta taatccagtt gaagaatata gaaggcaggg cctgcccaat     540

caccattgga ggataagttt tattaacaag tgctatgagc tctgtgagac ataccctgct     600

cttttggtgg ttccctatcg gacctcagat gatgatctta ggaggatcgc aacgtttaga     660

tcccgaaatc ggcttcctgt actgtcgtgg attcacccag aaaacaaaat ggtcattatg     720

cgctgcagtc agcctcttgt cggtatgagt ggtaaaagaa ataaagatga cgagaaatac     780

ctggatgtga tcagggaaac taacaaacaa acttctaagc tcatgattta tgatgcacga     840

cccagtgtaa atgcagtcgc caacaaggca acaggaggag gatatgaaag tgatgacgca     900

tatcaaaact cagaactttc cttcttagac attcataata ttcatgttat gcgagaatct     960

ttaaaaaaag tgaaagatat tgtttatccc aacatagaag aatctcattg gttgtccagt    1020

ttggagtcta ctcattggtt agaacatatc aagcttgttc tgaccggtgc cattcaagtg    1080

gcagaccaag tgtcttcagg aaagagctcg gtacttgtgc actgcagtga cggatgggac    1140

aggaccgctc agctgacatc cttggccatg ctgatgttgg acagcttcta cagaactatt    1200

gaaggctttg agatattggt acagaaagag tggataagtt ttggccataa atttgcatct    1260

agaataggtc atggtgataa aaaccatgct gatgctgatc gatctcctat ttttcttcag    1320

tttattgact gtgtgtggca gatgtcgaaa cagttcccca cagcttttga gttcaatgaa    1380

ggctttttga ttaccgtttt ggatcatctg tatagctgtc gatttggtac tttcttattc    1440

aactgtgact cggctcgaga aagacagaaa cttacagaaa gaacagtttc tctatggtcg    1500

ctaattaaca gcaataaaga caaattcaaa aaccccttct atacaaaaga aatcaatcgg    1560

gttttgtatc cagttgccag catgcgtcac ttggaactgt gggtgaatta ttacatccga    1620

tggaatccca gggtcaagca gcaacagccc aacccagtgg agcagcgtta catggagctt    1680

ttggccttgc gtgacgatta tataaagagg ctcgaggaat tgcagctggc caactccgcc    1740

aagcttgctg atgcccccgc ttcgacttcc agttcgtcac agatggtgcc ccatgtgcag    1800

acgcacttct ga                                                        1812


<210> 15
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..22
<223> /mol_type="unassigned DNA"
      /note="AAV forward"
      /organism="Artificial Sequence"

<400> 15
ctccatcact aggggttcct tg                                             22


<210> 16
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..18
<223> /mol_type="unassigned DNA"
      /note="AAV reverse"
      /organism="Artificial Sequence"

<400> 16
gtagataagt agcatggc                                                  18


<210> 17
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..17
<223> /mol_type="unassigned DNA"
      /note="AAV probe"
      /organism="Artificial Sequence"

<400> 17
tagttaatga ttaaccc                                                   17


<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="Titine forward"
      /organism="Artificial Sequence"

<400> 18
aaaacgagca gtgacgtgag c                                              21


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="Titine reverse"
      /organism="Artificial Sequence"

<400> 19
ttcagtcatg ctgctagcgc                                                20


<210> 20
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..25
<223> /mol_type="unassigned DNA"
      /note="Ttine probe"
      /organism="Artificial Sequence"

<400> 20
tgcacggaag cgtctcgtct cagtc                                          25


<210> 21
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..16
<223> /mol_type="unassigned DNA"
      /note="CAPN3sfr.f "
      /organism="Artificial Sequence"

<400> 21
cgcctccaag gcccgt                                                    16


<210> 22
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..16
<223> /mol_type="unassigned DNA"
      /note="CAPN3sfr.r "
      /organism="Artificial Sequence"

<400> 22
ggcggaagcg ctggct                                                    16


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /note="MGBTUCAPN3.p "
      /organism="Artificial Sequence"

<400> 23
ctacatcaac atgagagagg t                                              21


<210> 24
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..16
<223> /mol_type="unassigned DNA"
      /note="CAPN3.f "
      /organism="Artificial Sequence"

<400> 24
cgcctccaag gccagg                                                    16


<210> 25
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..16
<223> /mol_type="unassigned DNA"
      /note="CAPN3.r "
      /organism="Artificial Sequence"

<400> 25
ggcggaagcg ctggga                                                    16


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="CAPN3.p "
      /organism="Artificial Sequence"

<400> 26
tacatcaaca tgcgggaggt                                                20


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="MH181PO.F "
      /organism="Artificial Sequence"

<400> 27
ctccaagcag atgcagcaga                                                20


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /note="M267PO.R "
      /organism="Artificial Sequence"

<400> 28
accatgatgc gcaaggctat                                                20


<210> 29
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..22
<223> /mol_type="unassigned DNA"
      /note="M225PO.p "
      /organism="Artificial Sequence"

<400> 29
ccgtggtgct gatgggcaag aa                                             22


