                         SEQUENCE LISTING

<110>  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
       Weiner, David B
       Yan, Jian
 
<120>  IMPROVED VACCINES FOR HUMAN PAPILLOMA VIRUS AND METHODS FOR USING
        THE SAME

<130>  UPVG0025 WO3

<150>  61777198
<151>  2013-03-12

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV6 E6E7 DNA sequence

<400>  1
ggtaccggat ccgccaccat ggactggacc tggattctgt tcctggtggc cgctgccaca       60

cgggtgcaca gcgaaagcgc caatgccagc accagcgcta caaccatcga ccagctgtgc      120

aagaccttca acctgagcat gcacaccctg cagatcaact gcgtgttctg caagaacgcc      180

ctgaccaccg ccgagatcta cagctacgcc tacaagcagc tgaaggtgct gttcagaggc      240

ggctacccct atgccgcctg cgcctgctgc ctggaatttc acggcaagat caaccagtac      300

cggcacttcg actacgccgg ctacgccacc accgtggaag aggaaacaaa gcaggacatc      360

ctggacgtgc tgatccggtg ctacctgtgc cacaagcccc tgtgcgaggt ggaaaaagtg      420

aagcacatcc tgaccaaggc ccggttcatc aagctgaact gcacctggaa gggccggtgc      480

ctgcactgct ggaccacctg tatggaagat atgctgccca gaggccggaa gcggcggagc      540

catggcagac acgtgaccct gaaggacatc gtgctggacc tgcagccccc cgatcctgtg      600

ggcctgcact gttacgagca gctggtggac agcagcgagg acgaggtgga cgaagtggac      660

ggccaggaca gccagcccct gaagcagcac ttccagatcg tgacctgctg ctgcggctgc      720

gacagcaacg tgcggctggt ggtgcagtgc accgagacag acatcagaga ggtccagcag      780

ctcctgctgg gcaccctgaa catcgtgtgc cccatctgcg cccccaagac ctacccttac      840

gacgtgcccg actacgcctg atgactcgag ctc                                   873


<210>  2
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV6 E6E7 protein sequence

<400>  2

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Ser Ala Asn Ala Ser Thr Ser Ala Thr Thr Ile Asp Gln 
            20                  25                  30          


Leu Cys Lys Thr Phe Asn Leu Ser Met His Thr Leu Gln Ile Asn Cys 
        35                  40                  45              


Val Phe Cys Lys Asn Ala Leu Thr Thr Ala Glu Ile Tyr Ser Tyr Ala 
    50                  55                  60                  


Tyr Lys Gln Leu Lys Val Leu Phe Arg Gly Gly Tyr Pro Tyr Ala Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Leu Glu Phe His Gly Lys Ile Asn Gln Tyr Arg His 
                85                  90                  95      


Phe Asp Tyr Ala Gly Tyr Ala Thr Thr Val Glu Glu Glu Thr Lys Gln 
            100                 105                 110         


Asp Ile Leu Asp Val Leu Ile Arg Cys Tyr Leu Cys His Lys Pro Leu 
        115                 120                 125             


Cys Glu Val Glu Lys Val Lys His Ile Leu Thr Lys Ala Arg Phe Ile 
    130                 135                 140                 


Lys Leu Asn Cys Thr Trp Lys Gly Arg Cys Leu His Cys Trp Thr Thr 
145                 150                 155                 160 


Cys Met Glu Asp Met Leu Pro Arg Gly Arg Lys Arg Arg Ser His Gly 
                165                 170                 175     


Arg His Val Thr Leu Lys Asp Ile Val Leu Asp Leu Gln Pro Pro Asp 
            180                 185                 190         


Pro Val Gly Leu His Cys Tyr Glu Gln Leu Val Asp Ser Ser Glu Asp 
        195                 200                 205             


Glu Val Asp Glu Val Asp Gly Gln Asp Ser Gln Pro Leu Lys Gln His 
    210                 215                 220                 


Phe Gln Ile Val Thr Cys Cys Cys Gly Cys Asp Ser Asn Val Arg Leu 
225                 230                 235                 240 


Val Val Gln Cys Thr Glu Thr Asp Ile Arg Glu Val Gln Gln Leu Leu 
                245                 250                 255     


Leu Gly Thr Leu Asn Ile Val Cys Pro Ile Cys Ala Pro Lys Thr Tyr 
            260                 265                 270         


Pro Tyr Asp Val Pro Asp Tyr Ala 
        275                 280 


<210>  3
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV11 E6E7 DNA sequence

<400>  3
ggtaccggat ccgccaccat ggactggacc tggattctgt tcctggtggc cgctgccaca       60

agagtgcaca gcgagagcaa ggatgccagc accagcgcca ccagcatcga ccagctgtgc      120

aagaccttca acctgagcct gcacaccctg cagatccagt gcgtgttctg ccggaacgcc      180

ctgaccaccg ccgagatcta cgcctacgcc tacaagaacc tgaaggtcgt gtggcgggac      240

aacttcccct tcgccgcctg cgcctgctgc ctggaactgc agggcaagat caaccagtac      300

cggcacttca actacgccgc ttacgccccc accgtggaag aggaaacaaa cgaggacatc      360

ctgaaggtgc tgatccggtg ctacctgtgc cacaagcccc tgtgcgagat cgagaagctg      420

aagcacatcc tgggcaaggc ccggttcatc aagctgaaca accagtggaa gggccggtgc      480

ctgcactgct ggaccacctg tatggaagat ctgctgccca gaggccggaa gcggagaagc      540

cacggcagac tggtcaccct gaaggacatc gtgctggacc tgcagccccc cgatcctgtg      600

ggcctgcact gttacgagca gctggaagat agcagcgagg acgaggtgga caaagtggac      660

aagcaggacg cccagcccct gacccagcac taccagatcc tgacctgctg ctgcggctgc      720

gacagcaacg tgcggctggt ggtggaatgc accgacggcg acatccggca gctccaggat      780

ctgctgctgg gcaccctgaa catcgtgtgc cccatctgcg cccccaagcc ctacccctac      840

gacgtgcccg actacgcctg atgactcgag ctc                                   873


<210>  4
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV11 E6E7 protein sequence

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Ser Lys Asp Ala Ser Thr Ser Ala Thr Ser Ile Asp Gln 
            20                  25                  30          


Leu Cys Lys Thr Phe Asn Leu Ser Leu His Thr Leu Gln Ile Gln Cys 
        35                  40                  45              


Val Phe Cys Arg Asn Ala Leu Thr Thr Ala Glu Ile Tyr Ala Tyr Ala 
    50                  55                  60                  


Tyr Lys Asn Leu Lys Val Val Trp Arg Asp Asn Phe Pro Phe Ala Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Leu Glu Leu Gln Gly Lys Ile Asn Gln Tyr Arg His 
                85                  90                  95      


Phe Asn Tyr Ala Ala Tyr Ala Pro Thr Val Glu Glu Glu Thr Asn Glu 
            100                 105                 110         


Asp Ile Leu Lys Val Leu Ile Arg Cys Tyr Leu Cys His Lys Pro Leu 
        115                 120                 125             


Cys Glu Ile Glu Lys Leu Lys His Ile Leu Gly Lys Ala Arg Phe Ile 
    130                 135                 140                 


Lys Leu Asn Asn Gln Trp Lys Gly Arg Cys Leu His Cys Trp Thr Thr 
145                 150                 155                 160 


Cys Met Glu Asp Leu Leu Pro Arg Gly Arg Lys Arg Arg Ser His Gly 
                165                 170                 175     


Arg Leu Val Thr Leu Lys Asp Ile Val Leu Asp Leu Gln Pro Pro Asp 
            180                 185                 190         


Pro Val Gly Leu His Cys Tyr Glu Gln Leu Glu Asp Ser Ser Glu Asp 
        195                 200                 205             


Glu Val Asp Lys Val Asp Lys Gln Asp Ala Gln Pro Leu Thr Gln His 
    210                 215                 220                 


Tyr Gln Ile Leu Thr Cys Cys Cys Gly Cys Asp Ser Asn Val Arg Leu 
225                 230                 235                 240 


Val Val Glu Cys Thr Asp Gly Asp Ile Arg Gln Leu Gln Asp Leu Leu 
                245                 250                 255     


Leu Gly Thr Leu Asn Ile Val Cys Pro Ile Cys Ala Pro Lys Pro Tyr 
            260                 265                 270         


Pro Tyr Asp Val Pro Asp Tyr Ala 
        275                 280 


<210>  5
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV33 E6E7 DNA sequence

<400>  5
ggtaccgtcg acggatccgc caccatggac tggacctgga ttctgttcct ggtggccgct       60

gctacccggg tgcacagctt ccaggacacc gaggaaagcg gccggaccct gcacgatctg      120

tgccaggccc tggaaaccac catccacaac atcgagctgc agtgcgtgga atgcaagaag      180

cccctgcagc ggagcgaggt gtacgacgcc gacctgaccg tggtgtacag agagggcaac      240

cccttcggca tctgcaagct gtgcctgcgg ttcctgagca agatcagcga gtaccggcac      300

tacaactaca gcgtgtacgg caacaccctg gaacagaccg tgaagaagcc tctgaacgag      360

atcctgatcc ggtgcatcat ctgccagcgg cccctgaagc ggcacgtgga cctgaacaag      420

cggttccaca atatcagcgg cagatgggcc ggcagatgcg ccgcctgttg gagaagccgg      480

cggagagaga cagccctgcg gggcagaaag cggcggagca gaggccacaa gcccaccctg      540

aaagaatacg tgctggacct gtaccccgag cccaccgacc tgtacggcta cggccagctg      600

agcgacagca gcgacgagga cgagggcctg gacagacctg atggacaggc ccagcccgcc      660

accgccgact actacatcgt gacctgctgc cacacctgta acaccaccgt gcggctgtgc      720

gtgaacagca ccgccagcga cctgcggaca atccagcagc tcctgatggg caccgtgaac      780

atcgtgtgcc ctacctgcgc ccagctgtga ctcgagacgc gtgagctc                   828


<210>  6
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV33 E6E7 protein sequence

<400>  6

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Gln Asp Thr Glu Glu Ser Gly Arg Thr Leu His Asp Leu 
            20                  25                  30          


Cys Gln Ala Leu Glu Thr Thr Ile His Asn Ile Glu Leu Gln Cys Val 
        35                  40                  45              


Glu Cys Lys Lys Pro Leu Gln Arg Ser Glu Val Tyr Asp Ala Asp Leu 
    50                  55                  60                  


Thr Val Val Tyr Arg Glu Gly Asn Pro Phe Gly Ile Cys Lys Leu Cys 
65                  70                  75                  80  


Leu Arg Phe Leu Ser Lys Ile Ser Glu Tyr Arg His Tyr Asn Tyr Ser 
                85                  90                  95      


Val Tyr Gly Asn Thr Leu Glu Gln Thr Val Lys Lys Pro Leu Asn Glu 
            100                 105                 110         


Ile Leu Ile Arg Cys Ile Ile Cys Gln Arg Pro Leu Lys Arg His Val 
        115                 120                 125             


Asp Leu Asn Lys Arg Phe His Asn Ile Ser Gly Arg Trp Ala Gly Arg 
    130                 135                 140                 


Cys Ala Ala Cys Trp Arg Ser Arg Arg Arg Glu Thr Ala Leu Arg Gly 
145                 150                 155                 160 


Arg Lys Arg Arg Ser Arg Gly His Lys Pro Thr Leu Lys Glu Tyr Val 
                165                 170                 175     


Leu Asp Leu Tyr Pro Glu Pro Thr Asp Leu Tyr Gly Tyr Gly Gln Leu 
            180                 185                 190         


Ser Asp Ser Ser Asp Glu Asp Glu Gly Leu Asp Arg Pro Asp Gly Gln 
        195                 200                 205             


Ala Gln Pro Ala Thr Ala Asp Tyr Tyr Ile Val Thr Cys Cys His Thr 
    210                 215                 220                 


Cys Asn Thr Thr Val Arg Leu Cys Val Asn Ser Thr Ala Ser Asp Leu 
225                 230                 235                 240 


Arg Thr Ile Gln Gln Leu Leu Met Gly Thr Val Asn Ile Val Cys Pro 
                245                 250                 255     


Thr Cys Ala Gln Leu 
            260     


<210>  7
<211>  835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV58 E6E7 DNA sequence

<400>  7
ggtaccgttt aaacggatcc gccaccatgg actggacctg gattctgttc ctggtggccg       60

ctgctacccg ggtgcacagc ttccaggatg ccgaggaaag cggccggacc ctgcacgatc      120

tgtgccaggc cctggaaacc agcgtgcacg agatcgagct gaagtgcgtg gaatgcaaga      180

aaaccctgca gcggagcgag gtgtacgacg ccgacctgcg gatcgtgtac cgggacggca      240

accccttcgc cgtgtgcaaa gtgtgcctgc ggctgctgag caagatcagc gagtaccggc      300

actacaacta cagcctgtac ggcgacaccc tggaacagac cctgaagaag tgcctgaacg      360

agatcctgat ccggtgcatc atctgccagc ggcccctgaa gcggcacgtg gacctgaaca      420

agcggttcca caacatcagc ggccggtgga ccggcagatg cgccgtgtgt tggaggccca      480

ggcggagaca gacccaggtg cgcggcagaa agcggcggag cagaggcaac aaccccaccc      540

tgagagagta catcctggac ctgcaccccg agcccaccga cctgtttggc tacggccagc      600

tgtgcgacag cagcgacgag gacgagatcg gcctggacgg ccctgatgga caggcccagc      660

ccgccaccgc caactactac atcgtgacct gctgctacac ctgtggcacc accgtgcggc      720

tgtgcatcaa cagcaccacc accgacgtgc gcaccctgca gcagctcctg atgggcacct      780

gtaccatcgt gtgccccagc tgcgcccagc agtgactcga ggcggccgcg agctc           835


<210>  8
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV58 E6E7 protein sequence

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Gln Asp Ala Glu Glu Ser Gly Arg Thr Leu His Asp Leu 
            20                  25                  30          


Cys Gln Ala Leu Glu Thr Ser Val His Glu Ile Glu Leu Lys Cys Val 
        35                  40                  45              


Glu Cys Lys Lys Thr Leu Gln Arg Ser Glu Val Tyr Asp Ala Asp Leu 
    50                  55                  60                  


Arg Ile Val Tyr Arg Asp Gly Asn Pro Phe Ala Val Cys Lys Val Cys 
65                  70                  75                  80  


Leu Arg Leu Leu Ser Lys Ile Ser Glu Tyr Arg His Tyr Asn Tyr Ser 
                85                  90                  95      


Leu Tyr Gly Asp Thr Leu Glu Gln Thr Leu Lys Lys Cys Leu Asn Glu 
            100                 105                 110         


Ile Leu Ile Arg Cys Ile Ile Cys Gln Arg Pro Leu Lys Arg His Val 
        115                 120                 125             


Asp Leu Asn Lys Arg Phe His Asn Ile Ser Gly Arg Trp Thr Gly Arg 
    130                 135                 140                 


Cys Ala Val Cys Trp Arg Pro Arg Arg Arg Gln Thr Gln Val Arg Gly 
145                 150                 155                 160 


Arg Lys Arg Arg Ser Arg Gly Asn Asn Pro Thr Leu Arg Glu Tyr Ile 
                165                 170                 175     


Leu Asp Leu His Pro Glu Pro Thr Asp Leu Phe Gly Tyr Gly Gln Leu 
            180                 185                 190         


Cys Asp Ser Ser Asp Glu Asp Glu Ile Gly Leu Asp Gly Pro Asp Gly 
        195                 200                 205             


Gln Ala Gln Pro Ala Thr Ala Asn Tyr Tyr Ile Val Thr Cys Cys Tyr 
    210                 215                 220                 


Thr Cys Gly Thr Thr Val Arg Leu Cys Ile Asn Ser Thr Thr Thr Asp 
225                 230                 235                 240 


Val Arg Thr Leu Gln Gln Leu Leu Met Gly Thr Cys Thr Ile Val Cys 
                245                 250                 255     


Pro Ser Cys Ala Gln Gln 
            260         


<210>  9
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgE Leader DNA sequence

<400>  9
atggactgga cctggatcct gttcctggtg gccgctgcca cacgggtgca cagc             54


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE leader protein

<400>  10

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV6 peptide 7

<400>  11

Thr Ala Glu Ile Tyr Ser Tyr Ala Tyr Lys Gln Leu Lys Val Leu 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV11 peptide 7

<400>  12

Thr Ala Glu Ile Tyr Ala Tyr Ala Tyr Lys Asn Leu Lys Val Val 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV11 peptide 27

<400>  13

His Cys Tyr Glu Gln Leu Glu Asp Ser Ser Glu Asp Glu Val Asp 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV subdominant peptide 6

<400>  14

Phe Cys Lys Asn Ala Leu Thr Thr Ala Glu Ile Tyr Ser Tyr Ala 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV subdominant peptide 9

<400>  15

Leu Phe Arg Gly Gly Tyr Pro Tyr Ala Ala Cys Ala Cys Cys Leu 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV subdominant peptide 13

<400>  16

Tyr Ala Gly Tyr Ala Thr Thr Val Glu Glu Glu Thr Lys Gln Asp 
1               5                   10                  15  


<210>  17
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX3005 insert HPV31 E6/E7 DNA sequence

<400>  17
atggactgga catggattct gttcctggtc gccgccgcaa ctagagtgca ttcattcaaa       60

aaccccgccg agtctgggag aaaactgcac gagctgagct ccgcactgga gatcccctac      120

gatgaactga ggctgaactg cgtgtattgt aaaggacagc tgactgagac cgaagtgctg      180

gacactgatc tgaccattgt ctaccgagac gatacacctt atggcgtgtg cactaaatgt      240

ctgcgcttct actcaaaggt gagcgagttt agatggtaca ggtatagcgt ctatggcacc      300

acactggaaa aactgacaaa caaggggatc tgcgacctgc tgatcaggtg cattacttgt      360

cagcgccctc tgcagcgaca cctggataag aagaagcggt tccataatat cggcgggcgg      420

tggaccggga gatgcatcgt gtgctggcgg agaccacgga cagagactca ggtccgaggg      480

cggaaaaggc gctctagagg agaaacccca acactgcagg actacgtgct ggatctgcag      540

cccgaggcca cagacctgca tggatatggc cagctgcccg actctagtga tgaggaagac      600

gtgatcgata gtcccgccgg ccaggctaag cctgatacct ccaactacaa tattgtcaca      660

ttttgctgtc agtgcgaatc cactctgagg ctgtgcgtgc agtctaccca ggtcgacatc      720

cgcattctgc aggaactgct gatgggatct ttcggaatcg tgtgccctaa ttgctccacc      780

agactgtgat aa                                                          792


<210>  18
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pGX3005  insert HPV31 E6/E7 protein sequence

<400>  18

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Lys Asn Pro Ala Glu Ser Gly Arg Lys Leu His Glu Leu 
            20                  25                  30          


Ser Ser Ala Leu Glu Ile Pro Tyr Asp Glu Leu Arg Leu Asn Cys Val 
        35                  40                  45              


Tyr Cys Lys Gly Gln Leu Thr Glu Thr Glu Val Leu Asp Thr Asp Leu 
    50                  55                  60                  


Thr Ile Val Tyr Arg Asp Asp Thr Pro Tyr Gly Val Cys Thr Lys Cys 
65                  70                  75                  80  


Leu Arg Phe Tyr Ser Lys Val Ser Glu Phe Arg Trp Tyr Arg Tyr Ser 
                85                  90                  95      


Val Tyr Gly Thr Thr Leu Glu Lys Leu Thr Asn Lys Gly Ile Cys Asp 
            100                 105                 110         


Leu Leu Ile Arg Cys Ile Thr Cys Gln Arg Pro Leu Gln Arg His Leu 
        115                 120                 125             


Asp Lys Lys Lys Arg Phe His Asn Ile Gly Gly Arg Trp Thr Gly Arg 
    130                 135                 140                 


Cys Ile Val Cys Trp Arg Arg Pro Arg Thr Glu Thr Gln Val Arg Gly 
145                 150                 155                 160 


Arg Lys Arg Arg Ser Arg Gly Glu Thr Pro Thr Leu Gln Asp Tyr Val 
                165                 170                 175     


Leu Asp Leu Gln Pro Glu Ala Thr Asp Leu His Gly Tyr Gly Gln Leu 
            180                 185                 190         


Pro Asp Ser Ser Asp Glu Glu Asp Val Ile Asp Ser Pro Ala Gly Gln 
        195                 200                 205             


Ala Lys Pro Asp Thr Ser Asn Tyr Asn Ile Val Thr Phe Cys Cys Gln 
    210                 215                 220                 


Cys Glu Ser Thr Leu Arg Leu Cys Val Gln Ser Thr Gln Val Asp Ile 
225                 230                 235                 240 


Arg Ile Leu Gln Glu Leu Leu Met Gly Ser Phe Gly Ile Val Cys Pro 
                245                 250                 255     


Asn Cys Ser Thr Arg Leu 
            260         


<210>  19
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX3007 insert  HPV52 E6/E7 DNA sequence

<400>  19
atggactgga cctggattct gttcctggtg gctgctgcta cacgggtgca ttcatttgaa       60

gaccctgcta catctggacg aactctgcac gagctgtgcg aagtgctgga ggaatctgtc      120

catgagatca ggctgcagtg cgtgcagtgt aagaaagagc tgcagcggag agaagtgtac      180

aagaccgacc tgcggattgt ctacagagat aacaatccct atggagtgtg catcatgtgc      240

ctgcggttcc tgtctaaaat tagtgaatac agacactacc agtattccct gtatggcaag      300

acactggagg aacgagtgcg gaaaccactg tctgagatca ccattcgctg catcatttgt      360

cagacacccc tggaacgaca cgtcaacgca aacaagcggt tccataacat catgggaagg      420

tggactggcc gctgcagtga gtgttggaga ccaaggcctg tgacccaggt ccgcggacga      480

aaacggcgga gccggggcga caaggcaacc atcaaagact acattctgga tctgcagcct      540

gagaccacag atctgcatgg ctatgggcag ctgggggaca gctccgatga ggaagacaca      600

gatggggtgg acagaccaga tggacaggcc gaacaggcta caagcaatta ctatatcgtc      660

acttattgcc actcatgtga cagcactctg aggctgtgca ttcattccac tgctaccgat      720

ctgcgcacac tgcagcagat gctgctggga acactgcagg tggtctgtcc aggatgtgcc      780

cgactgtgat aa                                                          792


<210>  20
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pGX3007 insert HPV52 E6/E7 protein sequence

<400>  20

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Glu Asp Pro Ala Thr Ser Gly Arg Thr Leu His Glu Leu 
            20                  25                  30          


Cys Glu Val Leu Glu Glu Ser Val His Glu Ile Arg Leu Gln Cys Val 
        35                  40                  45              


Gln Cys Lys Lys Glu Leu Gln Arg Arg Glu Val Tyr Lys Thr Asp Leu 
    50                  55                  60                  


Arg Ile Val Tyr Arg Asp Asn Asn Pro Tyr Gly Val Cys Ile Met Cys 
65                  70                  75                  80  


Leu Arg Phe Leu Ser Lys Ile Ser Glu Tyr Arg His Tyr Gln Tyr Ser 
                85                  90                  95      


Leu Tyr Gly Lys Thr Leu Glu Glu Arg Val Arg Lys Pro Leu Ser Glu 
            100                 105                 110         


Ile Thr Ile Arg Cys Ile Ile Cys Gln Thr Pro Leu Glu Arg His Val 
        115                 120                 125             


Asn Ala Asn Lys Arg Phe His Asn Ile Met Gly Arg Trp Thr Gly Arg 
    130                 135                 140                 


Cys Ser Glu Cys Trp Arg Pro Arg Pro Val Thr Gln Val Arg Gly Arg 
145                 150                 155                 160 


Lys Arg Arg Ser Arg Gly Asp Lys Ala Thr Ile Lys Asp Tyr Ile Leu 
                165                 170                 175     


Asp Leu Gln Pro Glu Thr Thr Asp Leu His Gly Tyr Gly Gln Leu Gly 
            180                 185                 190         


Asp Ser Ser Asp Glu Glu Asp Thr Asp Gly Val Asp Arg Pro Asp Gly 
        195                 200                 205             


Gln Ala Glu Gln Ala Thr Ser Asn Tyr Tyr Ile Val Thr Tyr Cys His 
    210                 215                 220                 


Ser Cys Asp Ser Thr Leu Arg Leu Cys Ile His Ser Thr Ala Thr Asp 
225                 230                 235                 240 


Leu Arg Thr Leu Gln Gln Met Leu Leu Gly Thr Leu Gln Val Val Cys 
                245                 250                 255     


Pro Gly Cys Ala Arg Leu 
            260         


<210>  21
<211>  818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV genotype 16 E6-E7 DNA sequence

<400>  21
gaattcgcca ccatggactg gacctggatc ctgttcctgg tggccgccgc cacacgggtg       60

cacagcttcc aggaccccca ggagagcggc agaaagctgc ctcagctgtg taccgagctg      120

cagaccacca tccacgacat catcctggag tgtgtgtact gtaagcagca gctgctgagg      180

agagaggtgt acgaccggga cctgtgtatc gtgtacaggg acggcaatcc ctacgccgtg      240

tgtgacaagt gcctgaagtt ctacagcaag atcagcgagt accggcacta ctgctacagc      300

ctgtacggca ccaccctgga gcagcagtac aacaagcccc tgtgtgacct gctgatccgg      360

tgtatcaact gccagaagcc cctgcagaga cacctggaca agaagcagcg gttccacaac      420

atcaggggca gatggaccgg cagatgtatg agctgctgcc ggagcagcag aaccagaagg      480

gagacccagc tgagaggccg gaagagaaga agccacggcg atacccccac cctgcacgag      540

tacatgctgg acctgcagcc tgagaccacc gatctgtacg gctacggcca gctgaatgac      600

agcagcgagg aggaggatga gatcgacggc cctgccggcc aggccgagcc cgacagagcc      660

cactacaaca tcgtgacctt ttgctgtaag tgtgacagca ccctgagact gtgcgtgcag      720

agcacccacg tggacatcag aaccctggag gatctgctga tgggcaccct gggcatcgtg      780

tgtcccatct gctcccagaa accctgatga gcggccgc                              818


<210>  22
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV genotype 16 E6-E7 protein sequence

<400>  22

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Gln Asp Pro Gln Glu Ser Gly Arg Lys Leu Pro Gln Leu 
            20                  25                  30          


Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val 
        35                  40                  45              


Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Arg Asp Leu 
    50                  55                  60                  


Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys 
65                  70                  75                  80  


Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr Ser 
                85                  90                  95      


Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp 
            100                 105                 110         


Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Gln Arg His Leu 
        115                 120                 125             


Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg 
    130                 135                 140                 


Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155                 160 


Arg Gly Arg Lys Arg Arg Ser His Gly Asp Thr Pro Thr Leu His Glu 
                165                 170                 175     


Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly 
            180                 185                 190         


Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala 
        195                 200                 205             


Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
    210                 215                 220                 


Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val 
225                 230                 235                 240 


Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val 
                245                 250                 255     


Cys Pro Ile Cys Ser Gln Lys Pro 
            260                 


<210>  23
<211>  837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV genotype 18 E6-E7 DNA sequence

<400>  23
atggactgga cctggatcct gttcctggtg gccgctgcca cacgggtgca cagcgccaga       60

ttcgaggacc ccaccaggag cggctacaag ctgcccgatc tgtgtaccga gctgaacacc      120

agcctgcagg acatcgagat cacctgtgtg tactgtaaga ccgtgctgga gctgaccgag      180

gtgttcgaga aggacctgtt cgtggtgtac agggacagca tcccccacgc cgcctgccac      240

aagtgtatcg acttctacag ccggatccgg gagctgagac actacagcga cagcgtgtac      300

ggcgataccc tggagaagct gaccaacacc ggcctgtaca acctgctgat ccggtgcctg      360

agatgccaga agcccctgct gagacacctg aacgagaagc ggcggttcca caacatcgcc      420

ggccactaca gaggccagtg ccacagctgc tgtaacaggg ccaggcagga gagactgcag      480

cggagaagag agacccaggt gaggggcagg aagagaagaa gccacggccc caaggccacc      540

ctgcaggata tcgtgctgca cctggagccc cagaatgaga tccccgtgga tctgctgggc      600

cacggccagc tgtccgacag cgaggaggag aacgacgaga tcgacggcgt gaatcaccag      660

cacctgcctg ccagaagagc cgagcctcag aggcacacca tgctgtgtat gtgctgtaag      720

tgtgaggccc ggatcgaact ggtggtggag agcagcgccg acgacctgag agccttccag      780

cagctgttcc tgaacaccct gagcttcgtg tgtccttggt gtgccagcca gcagtga         837


<210>  24
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV genotype 18 E6-E7 protein sequence

<400>  24

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ala Arg Phe Glu Asp Pro Thr Arg Ser Gly Tyr Lys Leu Pro 
            20                  25                  30          


Asp Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr 
        35                  40                  45              


Cys Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Lys 
    50                  55                  60                  


Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala Cys His 
65                  70                  75                  80  


Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His Tyr Ser 
                85                  90                  95      


Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly Leu 
            100                 105                 110         


Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu Leu Arg 
        115                 120                 125             


His Leu Asn Glu Lys Arg Arg Phe His Asn Ile Ala Gly His Tyr Arg 
    130                 135                 140                 


Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg Gln Glu Arg Leu Gln 
145                 150                 155                 160 


Arg Arg Arg Glu Thr Gln Val Arg Gly Arg Lys Arg Arg Ser His Gly 
                165                 170                 175     


Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn 
            180                 185                 190         


Glu Ile Pro Val Asp Leu Leu Gly His Gly Gln Leu Ser Asp Ser Glu 
        195                 200                 205             


Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His Leu Pro Ala 
    210                 215                 220                 


Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys 
225                 230                 235                 240 


Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala Asp Asp Leu 
                245                 250                 255     


Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro 
            260                 265                 270         


Trp Cys Ala Ser Gln Gln 
        275             


