
                                SEQUENCE LISTING

<110>  Institute of Arthritis Research LLC
       Scoville, Craig D.

<120> IMMUNOLOGICALLY ACTIVE POLYPEPTIDE
  

<130> 750061.402WO

<140> PCT
<141> 2014-03-12

<150> US 61/777,568                
<151> 2013-03-12           

<160> 115

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide fragment

<400> 1
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
 1               5                  10

<210> 2
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide fragment

<400> 2
Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys
 1               5                  10

<210> 3
<211> 471
<212> PRT
<213> Homo sapiens

<400> 3
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly
 1               5                  10                  15
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30
Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ser Ser Gly Phe Thr Phe
        35                  40                  45
Gly Asp Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60
Glu Trp Val Gly Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Glu
65                  70                  75                  80
Tyr Ala Ala Ser Leu Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser
                85                  90                  95
Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr
            100                 105                 110
Ala Leu Tyr Tyr Cys Thr Arg Ser Leu Arg Gly Val Gln Gly Pro Leu
        115                 120                 125
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
    130                 135                 140
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
145                 150                 155                 160
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
                165                 170                 175
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
            180                 185                 190
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
        195                 200                 205
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
    210                 215                 220
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
225                 230                 235                 240
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
                245                 250                 255
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
            260                 265                 270
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
        275                 280                 285
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
    290                 295                 300
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
305                 310                 315                 320
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                325                 330                 335
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
            340                 345                 350
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
        355                 360                 365
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
    370                 375                 380
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
385                 390                 395                 400
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
                405                 410                 415
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
            420                 425                 430
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
        435                 440                 445
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
    450                 455                 460
Leu Ser Leu Ser Pro Gly Lys
465                 470

<210> 4
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide fragment
      

<400> 4
Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr
 1               5                  10                  15
Ala Leu Tyr Tyr Cys Thr Arg
            20

<210> 5
<211> 126
<212> PRT
<213> Homo sapiens

<400> 5
Leu Leu Glu Ser Gly Glu Gly Leu Val Gln Pro Gly Arg Ser Leu Arg
 1               5                  10                  15
Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser
            20                  25                  30
Trp Phe Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val Gly Phe Ile
        35                  40                  45
Arg Ser Glu Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys
    50                  55                  60
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu
65                  70                  75                  80
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr
                85                  90                  95
Arg Glu Glu Trp Gly Ser Gly Trp Asn Gly Tyr Tyr Phe Asp Tyr Trp
            100                 105                 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Ala
        115                 120                 125

<210> 6
<211> 123
<212> PRT
<213> Homo sapiens

<400> 6
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Pro Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Trp Gly Ser Gly Ser Ser Thr Asp Ala Phe Asp Ile
            100                 105                 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 7
<211> 125
<212> PRT
<213> Homo sapiens

<400> 7
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Gly Asp Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Glu Cys Gly Gly Asp Pro Leu Leu Tyr Tyr Phe Phe Ala Met
            100                 105                 110
Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120                 125

<210> 8
<211> 114
<212> PRT
<213> Homo sapiens

<400> 8
Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Thr Leu Ser Cys Ser Val
 1               5                  10                  15
Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Val Arg Gln Ala
            20                  25                  30
Pro Gly Lys Gly Leu Glu Trp Val Gly Leu Ile Arg Ser Lys Thr Tyr
        35                  40                  45
Arg Gly Thr Thr Asp Tyr Ala Ala Ser Val Lys Gly Arg Val Thr Ile
    50                  55                  60
Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
65                  70                  75                  80
Lys Ile Asp Asp Thr Ala Val Tyr Tyr Cys Gly Arg Thr Leu Gly Ser
                85                  90                  95
Gly Asn Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Val Trp Gly Leu Gly
            100                 105                 110
Thr Thr


<210> 9
<211> 116
<212> PRT
<213> Homo sapiens

<400> 9
Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala
 1               5                  10                  15
Ser Gly Phe Thr Phe Gly Asp Phe Val Met Ser Trp Phe Arg Gln Ala
            20                  25                  30
Pro Gly Arg Gly Leu Glu Trp Val Gly Leu Ile Arg Asn Lys Ala Tyr
        35                  40                  45
Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile
    50                  55                  60
Ser Arg Glu Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
65                  70                  75                  80
Lys Thr Asp Asp Ala Ala Val Tyr Tyr Cys Thr Arg Asp Lys Val Val
                85                  90                  95
Gly Ala Thr Met Asp Tyr His Tyr Tyr Tyr Gly Met Asp Val Trp Gly
            100                 105                 110
Gln Gly Thr Thr
        115

<210> 10
<211> 140
<212> PRT
<213> Homo sapiens

<400> 10
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Pro Gly Tyr Ser Ser Gly Cys Gly Tyr Trp Gly Gln Gly
            100                 105                 110
Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro Thr Leu Phe
        115                 120                 125
Pro Ser Ser Pro Val Arg Ile Pro Arg Arg Ile Arg
    130                 135                 140

<210> 11
<211> 145
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(145)
<223> Xaa = Any Amino Acid

<400> 11
Gly Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
 1               5                  10                  15
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr
            20                  25                  30
Phe Gly Asp Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly
        35                  40                  45
Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr
    50                  55                  60
Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
65                  70                  75                  80
Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp
                85                  90                  95
Thr Ala Val Tyr Tyr Cys Thr Arg Asp Gln Glu Gln Trp Leu Val Pro
            100                 105                 110
Gln Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly
        115                 120                 125
Ser Ala Ser Pro Gln Pro Phe Ser Pro Arg Leu Leu Xaa Lys Phe Pro
    130                 135                 140
Val
145

<210> 12
<211> 144
<212> PRT
<213> Homo sapiens

<400> 12
Lys Val Pro Val Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Leu
 1               5                  10                  15
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr
            20                  25                  30
Phe Gly Asp Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly
        35                  40                  45
Leu Glu Trp Val Gly Phe Val Arg Lys Gln Glu Tyr Gly Gly Thr Thr
    50                  55                  60
Glu Tyr Ala Ala Ser Val Arg Gly Arg Val Thr Ile Ser Arg Asp Asp
65                  70                  75                  80
Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Ser Asp Asp
                85                  90                  95
Thr Ala Val Tyr Tyr Cys Thr Gly Glu Leu Asp Leu Gly Ala Thr Tyr
            100                 105                 110
Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
        115                 120                 125
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
    130                 135                 140

<210> 13
<211> 144
<212> PRT
<213> Homo sapiens

<400> 13
Arg Cys Pro Val Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Leu
 1               5                  10                  15
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr
            20                  25                  30
Phe Gly Asp Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly
        35                  40                  45
Leu Glu Trp Val Gly Phe Val Arg Lys Gln Glu Tyr Gly Gly Thr Thr
    50                  55                  60
Glu Tyr Ala Ala Ser Val Arg Gly Arg Val Thr Ile Ser Arg Asp Asp
65                  70                  75                  80
Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Ser Asp Asp
                85                  90                  95
Thr Ala Val Tyr Tyr Cys Thr Gly Glu Leu Asp Leu Gly Ala Thr Tyr
            100                 105                 110
Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
        115                 120                 125
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
    130                 135                 140

<210> 14
<211> 144
<212> PRT
<213> Homo sapiens

<400> 14
Arg Cys Pro Val Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Leu
 1               5                  10                  15
Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr
            20                  25                  30
Phe Gly Asp Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly
        35                  40                  45
Leu Glu Trp Val Gly Phe Val Arg Lys Gln Glu Tyr Gly Gly Thr Thr
    50                  55                  60
Glu Tyr Ala Ala Ser Val Arg Gly Arg Val Thr Ile Ser Arg Asp Asp
65                  70                  75                  80
Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Ser Gly Asp
                85                  90                  95
Thr Ala Val Tyr Tyr Cys Thr Gly Glu Leu Asp Leu Gly Ala Thr Tyr
            100                 105                 110
Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val
        115                 120                 125
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
    130                 135                 140

<210> 15
<211> 143
<212> PRT
<213> Homo sapiens

<400> 15
Cys Pro Val Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Leu Gln
 1               5                  10                  15
Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe
            20                  25                  30
Gly Asp Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
        35                  40                  45
Glu Trp Val Gly Phe Val Arg Lys Gln Glu Tyr Gly Gly Thr Thr Glu
    50                  55                  60
Tyr Ala Ala Ser Val Arg Gly Arg Val Thr Ile Ser Arg Asp Asp Ser
65                  70                  75                  80
Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Ser Asp Asp Thr
                85                  90                  95
Ala Val Tyr Tyr Cys Thr Gly Glu Leu Asp Leu Gly Ala Thr Tyr Tyr
            100                 105                 110
Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
        115                 120                 125
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
    130                 135                 140

<210> 16
<211> 138
<212> PRT
<213> Homo sapiens

<400> 16
Val Gln Leu Val Glu Ser Gly Gly Asp Leu Leu Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Thr
            20                  25                  30
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Val Arg Lys Gln Glu Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Arg Gly Arg Val Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Gly Glu Leu Asp Leu Gly Ala Thr Tyr Tyr Tyr Tyr Gly Met
            100                 105                 110
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Pro
        115                 120                 125
Arg Ala His Arg Ser Ser Pro Gly Ala Leu
    130                 135

<210> 17
<211> 139
<212> PRT
<213> Homo sapiens

<400> 17
Val Gln Leu Val Glu Ser Gly Gly Asp Leu Leu Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Thr
            20                  25                  30
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Val Arg Lys Gln Glu Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Arg Gly Arg Val Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Gly Glu Leu Asp Leu Gly Ala Thr Tyr Tyr Tyr Tyr Gly Met
            100                 105                 110
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser
    130                 135

<210> 18
<211> 120
<212> PRT
<213> Homo sapiens

<400> 18
Gln Val Gln Leu Val His Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30
Ala Val Ser Trp Phe Arg Gln Ala Pro Gly Lys Ala Pro Glu Trp Val
        35                  40                  45
Gly Leu Ile Arg Ser Arg His Tyr Gly Ala Lys Thr Gln Phe Ala Ala
    50                  55                  60
Ser Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Asn Thr Ser Ser Leu Ala Val Ala Gly Asn Trp Gly Gln
            100                 105                 110
Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 19
<211> 100
<212> PRT
<213> Homo sapiens

<400> 19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg
            100

<210> 20
<211> 131
<212> PRT
<213> Homo sapiens

<400> 20
Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala
 1               5                  10                  15
Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Val Arg Gln Ala
            20                  25                  30
Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Pro Tyr
        35                  40                  45
Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile
    50                  55                  60
Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
65                  70                  75                  80
Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Val Ser Pro Glu
                85                  90                  95
Gly Gly Leu Val His Phe Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125
Leu Ala Pro
    130

<210> 21
<211> 128
<212> PRT
<213> Homo sapiens

<400> 21
Gly Leu Val Lys Pro Gly Arg Ser Gln Arg Leu Ser Cys Ile Ala Ser
 1               5                  10                  15
Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro
            20                  25                  30
Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Gly Lys Ala Tyr Gly
        35                  40                  45
Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser
    50                  55                  60
Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys
65                  70                  75                  80
Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Thr Gln Glu Trp Arg
                85                  90                  95
Glu Phe Arg Tyr Tyr Tyr Gly Ser Gly Ser Thr Pro Pro His Tyr Tyr
            100                 105                 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125

<210> 22
<211> 87
<212> PRT
<213> Homo sapiens

<400> 22
Asp Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu
 1               5                  10                  15
Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr
            20                  25                  30
Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys
        35                  40                  45
Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala
    50                  55                  60
Val Tyr Tyr Cys Thr Arg Ala Thr Phe Ser Phe Phe Asp Tyr Trp Gly
65                  70                  75                  80
Gln Gly Thr Leu Val Thr Val
                85

<210> 23
<211> 93
<212> PRT
<213> Homo sapiens

<400> 23
Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
 1               5                  10                  15
Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala
            20                  25                  30
Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser
        35                  40                  45
Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val
    50                  55                  60
Tyr Tyr Cys Thr Arg Thr Gly Tyr Tyr Tyr Asp Ser Ser Gly Tyr Phe
65                  70                  75                  80
Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu
                85                  90

<210> 24
<211> 115
<212> PRT
<213> Homo sapiens

<400> 24
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Gly Asp Tyr Gly
            20                  25                  30
Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Arg Lys Val Tyr Gly Glu Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Asp Asp Asp Phe Trp Ser Gly Tyr Ser Asp Tyr Trp Gly
            100                 105                 110
Gln Gly Thr
        115

<210> 25
<211> 117
<212> PRT
<213> Homo sapiens

<400> 25
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Asp Trp Glu Ile Ala Ala Arg Pro Glu Ser Phe Asp Tyr
            100                 105                 110
Trp Gly Gln Gly Thr
        115

<210> 26
<211> 112
<212> PRT
<213> Homo sapiens

<400> 26
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Val Asp Thr Ala Met Val Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110

<210> 27
<211> 113
<212> PRT
<213> Homo sapiens

<400> 27
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Val
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Asp Pro Val Val Gly Pro Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110
Thr


<210> 28
<211> 120
<212> PRT
<213> Homo sapiens

<400> 28
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Asp Arg Asp Tyr Asp Ile Leu Thr Gly Tyr Tyr Trp Ser
            100                 105                 110
Asp Tyr Gly Met Asp Val Trp Gly
        115                 120

<210> 29
<211> 114
<212> PRT
<213> Homo sapiens

<400> 29
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Ala Tyr Ser Ser Ser Tyr Tyr Tyr Tyr Gly Met Asp Val
            100                 105                 110
Trp Gly


<210> 30
<211> 115
<212> PRT
<213> Homo sapiens

<400> 30
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Ser Asn His Arg Ile Ala Ala Pro Val Gly Asn Tyr Trp Gly
            100                 105                 110
Gln Gly Thr
        115

<210> 31
<211> 115
<212> PRT
<213> Homo sapiens

<400> 31
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Ile Pro Ser Gly Ser Tyr His Tyr Tyr Tyr Gly Met Asp
            100                 105                 110
Val Trp Gly
        115

<210> 32
<211> 118
<212> PRT
<213> Homo sapiens

<400> 32
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Trp Gly Lys Glu Gly Ala Thr Thr Gly Glu Asn Phe Asp
            100                 105                 110
Tyr Trp Gly Gln Gly Thr
        115

<210> 33
<211> 110
<212> PRT
<213> Homo sapiens

<400> 33
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Asp Gly Ser Tyr Tyr Ala Phe Asp Ile Trp Gly
            100                 105                 110

<210> 34
<211> 107
<212> PRT
<213> Homo sapiens

<400> 34
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Pro Leu Val Tyr Trp Gly Gln Gly Thr
            100                 105

<210> 35
<211> 119
<212> PRT
<213> Homo sapiens

<400> 35
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Asp Pro Leu Leu Tyr Gly Ser Gly Ser Ser Arg Pro Tyr
            100                 105                 110
Asp Ala Phe Asp Ile Trp Gly
        115

<210> 36
<211> 123
<212> PRT
<213> Homo sapiens

<400> 36
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Gly Pro Pro Leu Pro Tyr Tyr Tyr Asp Ser Ser Gly Tyr
            100                 105                 110
Tyr Tyr Glu Gly Asp Tyr Trp Gly Gln Gly Thr
        115                 120

<210> 37
<211> 118
<212> PRT
<213> Homo sapiens

<400> 37
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Asp His Arg Ser Lys Trp Leu Phe Glu Asn Trp Phe Asp
            100                 105                 110
Pro Trp Gly Gln Gly Thr
        115

<210> 38
<211> 119
<212> PRT
<213> Homo sapiens

<400> 38
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Arg Ile Asp Ser Ser Ser Trp Tyr Pro Asp Tyr Tyr Tyr
            100                 105                 110
Tyr Gly Met Asp Val Trp Gly
        115

<210> 39
<211> 116
<212> PRT
<213> Homo sapiens

<400> 39
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Glu Trp Tyr Asp Ser Ser Gly Tyr Tyr Ala Tyr Gly Met
            100                 105                 110
Asp Val Trp Gly
        115

<210> 40
<211> 117
<212> PRT
<213> Homo sapiens

<400> 40
Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Asp Trp Glu Ile Ala Ala Arg Pro Glu Ser Phe Asp Tyr
            100                 105                 110
Trp Gly Gln Gly Thr
        115

<210> 41
<211> 118
<212> PRT
<213> Homo sapiens

<400> 41
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Lys Ser Asp His Met Ser Ser Trp Lys Val Asn Pro Phe Asp
            100                 105                 110
Tyr Trp Gly Gln Gly Thr
        115

<210> 42
<211> 118
<212> PRT
<213> Homo sapiens

<400> 42
Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Gly Ser Gly Phe Ile Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Thr Gly Tyr Gly Gly Thr Ile Gln Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Gly Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Arg Gly Pro Tyr Gly Ser Gly Ser Phe Asn Tyr Tyr Tyr
            100                 105                 110
Tyr Met Asp Val Trp Gly
        115

<210> 43
<211> 115
<212> PRT
<213> Homo sapiens

<400> 43
Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Gly Leu Ser Cys Thr Thr Ser Gly Phe Ser Phe Gly Asp Tyr Ala
            20                  25                  30
Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Val Val Arg Asn Lys Ala Tyr Gly Gly Thr Ala Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Glu Thr Gly Pro Leu Thr Gly Pro Leu Gly Tyr Trp Gly
            100                 105                 110
Gln Gly Thr
        115

<210> 44
<211> 111
<212> PRT
<213> Homo sapiens

<400> 44
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Gly Ala Gln Thr Trp Ile Asn Trp Gly Gln Gly Thr
            100                 105                 110

<210> 45
<211> 121
<212> PRT
<213> Homo sapiens

<400> 45
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Ser Val Ala Glu Tyr Gln Leu Thr Gly Tyr Gly Val Gly
            100                 105                 110
Gly Phe Phe Phe Trp Gly Gln Gly Thr
        115                 120

<210> 46
<211> 120
<212> PRT
<213> Homo sapiens

<400> 46
Gly Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Thr
            20                  25                  30
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Arg Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Leu Tyr Tyr
                85                  90                  95
Cys Thr Arg Asp Arg Arg Asn Tyr Tyr Asp Ser Ser Gly Tyr Trp Gly
            100                 105                 110
His Asp Ala Phe Asn Ile Trp Gly
        115                 120

<210> 47
<211> 112
<212> PRT
<213> Homo sapiens

<400> 47
Val Gln Met Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Phe Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Gln Tyr Val Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Ser Arg Glu Ser Phe Asp Asn Tyr Arg Ala Phe Asp Met Trp Gly
            100                 105                 110

<210> 48
<211> 129
<212> PRT
<213> Homo sapiens

<400> 48
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Gly Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Ile Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Asp Pro Phe Glu Gly Gly Leu Ile Ala Ala Arg Pro Trp
            100                 105                 110
Arg Gly Trp Met Leu Tyr Pro Ser Ala Phe Asp Tyr Trp Gly Gln Gly
        115                 120                 125
Thr


<210> 49
<211> 85
<212> PRT
<213> Homo sapiens

<400> 49
Asp Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu
 1               5                  10                  15
Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr
            20                  25                  30
Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys
        35                  40                  45
Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala
    50                  55                  60
Val Tyr Tyr Cys Thr Arg Ala Leu Tyr Ser Asn Phe Pro Ser Tyr Gly
65                  70                  75                  80
Met Asp Val Trp Gly
                85

<210> 50
<211> 91
<212> PRT
<213> Homo sapiens

<400> 50
Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Val Arg Gln Ala
 1               5                  10                  15
Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr
            20                  25                  30
Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile
        35                  40                  45
Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
    50                  55                  60
Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Leu Asn Thr
65                  70                  75                  80
Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Trp Gly
                85                  90

<210> 51
<211> 125
<212> PRT
<213> Homo sapiens

<400> 51
Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala
 1               5                  10                  15
Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Val Arg Gln Ala
            20                  25                  30
Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr
        35                  40                  45
Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile
    50                  55                  60
Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
65                  70                  75                  80
Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Gly Ser Glu Val
                85                  90                  95
Tyr Cys Ser Ser Thr Ser Cys Tyr Asp Asn Tyr Tyr Tyr Tyr Tyr Met
            100                 105                 110
Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125

<210> 52
<211> 128
<212> PRT
<213> Homo sapiens

<400> 52
Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala
 1               5                  10                  15
Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Val Arg Gln Ala
            20                  25                  30
Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr
        35                  40                  45
Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile
    50                  55                  60
Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
65                  70                  75                  80
Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Pro Ala Met
                85                  90                  95
Ala Gln Tyr Tyr Asp Tyr Val Trp Gly Ser Tyr Thr Arg Ala Tyr Tyr
            100                 105                 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120                 125

<210> 53
<211> 112
<212> PRT
<213> Homo sapiens

<400> 53
Gly Gly Leu Val Lys Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala
 1               5                  10                  15
Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Phe Arg Gln Ala
            20                  25                  30
Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr
        35                  40                  45
Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile
    50                  55                  60
Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
65                  70                  75                  80
Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Leu Gly Pro Tyr
                85                  90                  95
Tyr Asp Phe Trp Ser Gly Tyr Tyr Phe Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110

<210> 54
<211> 80
<212> PRT
<213> Homo sapiens

<400> 54
Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Phe
 1               5                  10                  15
Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val
            20                  25                  30
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr
        35                  40                  45
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Leu Tyr Tyr Cys
    50                  55                  60
Thr Arg Ala Pro Ala Ile Ala Ser Gly Gly Pro Phe Asp Pro Trp Gly
65                  70                  75                  80

<210> 55
<211> 118
<212> PRT
<213> Homo sapiens

<400> 55
Glu Val Ala Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Val Ala
 1               5                  10                  15
Val Pro Glu Thr Leu Leu Val Ser Ala Ser Gly Phe Thr Phe Gly Asp
            20                  25                  30
His Val Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Pro Asp Trp
        35                  40                  45
Val Gly Phe Ile Arg Ser Lys Val Tyr Gly Gly Thr Ala Glu Tyr Ala
    50                  55                  60
Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser
65                  70                  75                  80
Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Gly Ile
                85                  90                  95
Tyr Tyr Cys Ala Arg Asp His Tyr Ser Asn Phe Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 56
<211> 106
<212> PRT
<213> Homo sapiens

<400> 56
Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Val Arg
 1               5                  10                  15
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys
            20                  25                  30
Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe
        35                  40                  45
Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn
    50                  55                  60
Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Ala Thr
65                  70                  75                  80
Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Phe Leu Asp Asn Pro Gly Tyr
                85                  90                  95
Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105

<210> 57
<211> 112
<212> PRT
<213> Homo sapiens

<400> 57
Glu Val Gln Met Val Val Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Cys Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Asp Pro Ile Thr Gly Ser Ser Trp Tyr Asp Tyr Trp
            100                 105                 110

<210> 58
<211> 100
<212> PRT
<213> Homo sapiens

<400> 58
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg
            100

<210> 59
<211> 100
<212> PRT
<213> Homo sapiens

<400> 59
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg
            100

<210> 60
<211> 134
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(134)
<223> Xaa = Any Amino Acid

<400> 60
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
 1               5                  10                  15
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
            20                  25                  30
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
        35                  40                  45
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
    50                  55                  60
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
65                  70                  75                  80
Cys Thr Arg Asp Gly Phe Tyr Asp Tyr Ile Trp Gly Ser Tyr Arg Tyr
                85                  90                  95
Thr Tyr Glu Gly Phe Ser Asp Tyr Trp Gly Gln Gly Thr Xaa Val Thr
            100                 105                 110
Val Ser Ser Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser
        115                 120                 125
Cys Glu Asn Ser Pro Ser
    130

<210> 61
<211> 107
<212> PRT
<213> Homo sapiens

<400> 61
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly
 1               5                  10                  15
Asp Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu
            20                  25                  30
Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr
        35                  40                  45
Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys
    50                  55                  60
Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala
65                  70                  75                  80
Val Tyr Tyr Cys Thr Arg Ser Gly Pro Ser Asp Tyr Tyr Asp Phe Trp
                85                  90                  95
Ser Gly Tyr Tyr Gly Gly Tyr Phe Asp Tyr Trp
            100                 105

<210> 62
<211> 143
<212> PRT
<213> Homo sapiens

<400> 62
Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met
 1               5                  10                  15
Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Phe
            20                  25                  30
Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val
        35                  40                  45
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr
    50                  55                  60
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys
65                  70                  75                  80
Thr Arg Ala Gln Leu Ile Leu Val Val Pro Ala Ala Ser Trp Asp Tyr
                85                  90                  95
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser
            100                 105                 110
Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn Ser Pro
        115                 120                 125
Ser Gly Tyr Glu Gln Arg Ala Val Gly Cys Ser His Arg Ile Leu
    130                 135                 140

<210> 63
<211> 92
<212> PRT
<213> Homo sapiens

<400> 63
Phe Gly Glu Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly
 1               5                  10                  15
Leu Glu Trp Val Gly Tyr Ile Arg Ser Lys Pro Phe Gly Gly Thr Ala
            20                  25                  30
Tyr Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
        35                  40                  45
Thr Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp
    50                  55                  60
Thr Ala Val Tyr Phe Cys Thr Arg Glu Tyr Arg Gly Ser Gly Ser Ser
65                  70                  75                  80
Ala Leu Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly
                85                  90

<210> 64
<211> 103
<212> PRT
<213> Homo sapiens

<400> 64
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
 1               5                  10                  15
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
            20                  25                  30
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
        35                  40                  45
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
    50                  55                  60
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
65                  70                  75                  80
Cys Thr Arg Gly Tyr Cys Ser Gly Gly Ser Cys Leu Tyr Tyr Tyr Tyr
                85                  90                  95
Tyr Gly Met Asp Val Trp Gly
            100

<210> 65
<211> 98
<212> PRT
<213> Homo sapiens

<400> 65
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
 1               5                  10                  15
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
            20                  25                  30
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
        35                  40                  45
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
    50                  55                  60
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
65                  70                  75                  80
Cys Thr Arg Ala Arg Gly Tyr Ser Ser Gly Trp Tyr Tyr Phe Asp Tyr
                85                  90                  95
Trp Gly


<210> 66
<211> 98
<212> PRT
<213> Homo sapiens

<400> 66
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
 1               5                  10                  15
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
            20                  25                  30
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
        35                  40                  45
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
    50                  55                  60
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
65                  70                  75                  80
Cys Thr Arg Asp Gly Gly Gln Gln Leu Gly Arg Thr Lys Phe Asp Tyr
                85                  90                  95
Trp Gly


<210> 67
<211> 72
<212> PRT
<213> Homo sapiens

<400> 67
Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly
 1               5                  10                  15
Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
            20                  25                  30
Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr
        35                  40                  45
Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Ala Gly Val Ala Thr Thr
    50                  55                  60
Arg Gly Lys Phe Asp Tyr Trp Gly
65                  70

<210> 68
<211> 97
<212> PRT
<213> Homo sapiens

<400> 68
Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Phe Arg Gln
 1               5                  10                  15
Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala
            20                  25                  30
Tyr Gly Gly Thr Thr Glu Tyr Thr Ala Ser Val Lys Gly Arg Phe Thr
        35                  40                  45
Ile Ser Arg Asp Gly Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser
    50                  55                  60
Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Gly Arg
65                  70                  75                  80
Asp Ile Val Val Val Val Pro Ala Val Leu Asn Trp Phe Asp Pro Trp
                85                  90                  95
Gly


<210> 69
<211> 92
<212> PRT
<213> Homo sapiens

<400> 69
Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Phe Arg Gln Ala
 1               5                  10                  15
Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr
            20                  25                  30
Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile
        35                  40                  45
Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
    50                  55                  60
Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ser Thr Thr Val Ala
65                  70                  75                  80
Gly Trp Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly
                85                  90

<210> 70
<211> 76
<212> PRT
<213> Homo sapiens

<400> 70
Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr
 1               5                  10                  15
Gly Gly Thr Thr Glu Tyr Thr Ala Ser Val Lys Gly Arg Phe Thr Ile
            20                  25                  30
Ser Arg Asp Gly Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
        35                  40                  45
Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Gln Leu Asn
    50                  55                  60
Pro Val Thr Asn Glu Gly Ile Phe Asp Tyr Trp Gly
65                  70                  75

<210> 71
<211> 103
<212> PRT
<213> Homo sapiens

<400> 71
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
 1               5                  10                  15
Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
            20                  25                  30
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
        35                  40                  45
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
    50                  55                  60
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
65                  70                  75                  80
Cys Thr Arg Val Gln Asn Trp Ala Ile Val Val Val Val Ala Ala Thr
                85                  90                  95
Pro Val Ala Asp Tyr Trp Gly
            100

<210> 72
<211> 74
<212> PRT
<213> Homo sapiens

<400> 72
Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr
 1               5                  10                  15
Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile
            20                  25                  30
Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
        35                  40                  45
Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Gly Gly Phe
    50                  55                  60
Ser Ser Gly Trp Arg Phe Asp Tyr Trp Gly
65                  70

<210> 73
<211> 75
<212> PRT
<213> Homo sapiens

<400> 73
Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr
 1               5                  10                  15
Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile
            20                  25                  30
Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
        35                  40                  45
Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Leu Ser Glu
    50                  55                  60
Leu Leu Tyr Tyr Tyr Gly Met Asp Val Trp Gly
65                  70                  75

<210> 74
<211> 92
<212> PRT
<213> Homo sapiens

<400> 74
Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro
 1               5                  10                  15
Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly
            20                  25                  30
Gly Thr Thr Glu Tyr Thr Ala Ser Val Lys Gly Arg Phe Thr Ile Ser
        35                  40                  45
Arg Asp Gly Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys
    50                  55                  60
Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Val Thr Gly Val Val
65                  70                  75                  80
Val Pro Ala Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly
                85                  90

<210> 75
<211> 79
<212> PRT
<213> Homo sapiens

<400> 75
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser
 1               5                  10                  15
Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg
            20                  25                  30
Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met
        35                  40                  45
Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Ile
    50                  55                  60
Gly Val Phe Gly Asp Tyr Gly Tyr Trp Tyr Phe Asp Leu Trp Gly
65                  70                  75

<210> 76
<211> 107
<212> PRT
<213> Homo sapiens

<400> 76
Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys
 1               5                  10                  15
Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Val Arg
            20                  25                  30
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys
        35                  40                  45
Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe
    50                  55                  60
Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn
65                  70                  75                  80
Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ser Gly Arg
                85                  90                  95
Arg Trp Tyr Leu Asp Tyr Trp Gly Gln Gly Thr
            100                 105

<210> 77
<211> 126
<212> PRT
<213> Homo sapiens

<400> 77
Met Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro
 1               5                  10                  15
Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly
            20                  25                  30
Asp Tyr Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45
Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Asp Tyr
    50                  55                  60
Ala Ala Ser Val Lys Gly Arg Phe Ser Met Ser Arg Asp Asp Ser Lys
65                  70                  75                  80
Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala
                85                  90                  95
Val Tyr Tyr Cys Thr Arg Gly Asp Asp Tyr Tyr Gly Ser Gly Thr Tyr
            100                 105                 110
Ile Pro Arg Asp Tyr Trp Asp His Gly His Arg Leu Asn His
        115                 120                 125

<210> 78
<211> 124
<212> PRT
<213> Homo sapiens

<400> 78
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Gln Ala Tyr Ser Gly Thr Thr Ala Tyr Ala Ala
    50                  55                  60
Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Ser Arg Asp Arg Glu Thr Ser Ala Ala Ala Arg Pro Phe Asp
            100                 105                 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 79
<211> 127
<212> PRT
<213> Homo sapiens

<400> 79
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser
 1               5                  10                  15
Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala
            20                  25                  30
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly
        35                  40                  45
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
    50                  55                  60
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
65                  70                  75                  80
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Thr Arg Ala Pro Arg Leu Glu Leu Arg Arg Tyr Tyr Tyr Tyr Tyr
            100                 105                 110
Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125

<210> 80
<211> 101
<212> PRT
<213> Homo sapiens

<400> 80
Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Val Arg
 1               5                  10                  15
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys
            20                  25                  30
Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe
        35                  40                  45
Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn
    50                  55                  60
Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ser His Ser
65                  70                  75                  80
Ser Ser Trp Asp Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp
                85                  90                  95
Gly Lys Gly Thr Thr
            100

<210> 81
<211> 126
<212> PRT
<213> Homo sapiens

<400> 81
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly
 1               5                  10                  15
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30
Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe
        35                  40                  45
Gly Asp Tyr Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60
Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu
65                  70                  75                  80
Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser
                85                  90                  95
Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr
            100                 105                 110
Ala Val Tyr Tyr Cys Thr Arg Asp Thr Val Arg Gly Gly Gln
        115                 120                 125

<210> 82
<211> 118
<212> PRT
<213> Homo sapiens

<400> 82
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Val Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45
Ala Phe Ile Arg Ser Lys Ala Ser Gly Glu Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Gln Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Ser Cys Asn Gly Tyr Tyr Asp Ser Ser Gly Tyr Tyr Ser Asp Tyr Pro
            100                 105                 110
Val Val Thr Asn Pro Val
        115

<210> 83
<211> 125
<212> PRT
<213> Homo sapiens

<400> 83
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Asp Arg Pro Leu Val Pro Arg Ser Glu Trp Phe Asp
            100                 105                 110
Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly
        115                 120                 125

<210> 84
<211> 97
<212> PRT
<213> Homo sapiens

<400> 84
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
 1               5                  10                  15
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
            20                  25                  30
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
        35                  40                  45
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
    50                  55                  60
Tyr Cys Thr Arg Val Arg Thr Pro Pro Asp Leu Ile Ile Val Val Val
65                  70                  75                  80
Pro Ala Ala Ser Leu Asp Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys
                85                  90                  95
Gly


<210> 85
<211> 133
<212> PRT
<213> Homo sapiens

<400> 85
Leu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Asp Ala Arg Leu Gln Tyr Tyr Asp Phe Trp Ser Gly
            100                 105                 110
Tyr Tyr Thr Ala Pro Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu
        115                 120                 125
Val Thr Val Ser Ser
    130

<210> 86
<211> 130
<212> PRT
<213> Homo sapiens

<400> 86
Leu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Asp Leu Gln Lys Trp Asp Cys Ser Gly Gly Ser Cys
            100                 105                 110
Phe Thr Ser Gly Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
        115                 120                 125
Ser Ser
    130

<210> 87
<211> 133
<212> PRT
<213> Homo sapiens

<400> 87
Leu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Arg Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Asp Ala Arg Leu Gln Tyr Tyr Asp Phe Trp Ser Gly
            100                 105                 110
Tyr Tyr Thr Ala Pro Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu
        115                 120                 125
Val Thr Val Ser Ser
    130

<210> 88
<211> 131
<212> PRT
<213> Homo sapiens

<400> 88
Leu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Pro Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Asp Gln Asp Cys Thr Asn Gly Val Cys Tyr Thr Phe
            100                 105                 110
Gly Val Glu Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125
Val Ser Ser
    130

<210> 89
<211> 170
<212> PRT
<213> Homo sapiens

<400> 89
Trp Val Phe Leu Val Ala Ile Leu Lys Gly Val Gln Cys Glu Val Gln
 1               5                  10                  15
Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Arg Ser Leu Thr
            20                  25                  30
Leu Ser Cys Thr Ser Ser Gly Leu Thr Phe Asp Asp Tyr Phe Met Ser
        35                  40                  45
Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile
    50                  55                  60
Arg Ser Lys Thr Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Gln
65                  70                  75                  80
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu
                85                  90                  95
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Ile Tyr Tyr Cys Ser
            100                 105                 110
Pro Gly Gly Ser Ala Tyr Tyr His Glu Asp Phe Gln Gln Trp Gly Pro
        115                 120                 125
Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
    130                 135                 140
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
145                 150                 155                 160
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro
                165                 170

<210> 90
<211> 172
<212> PRT
<213> Homo sapiens

<400> 90
Trp Val Phe Leu Val Ala Ile Leu Lys Gly Val Gln Cys Glu Val Gln
 1               5                  10                  15
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg
            20                  25                  30
Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr Ala Met Ile
        35                  40                  45
Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Phe Ile
    50                  55                  60
Arg Lys Lys Ala Tyr Gly Gly Thr Thr Asp Tyr Ala Ala Ser Val Lys
65                  70                  75                  80
Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu
                85                  90                  95
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Leu Tyr Tyr Cys Thr
            100                 105                 110
Arg Asp Ser Glu Gly Trp Gly Val Tyr Tyr Tyr Gly Met Asp Val Trp
        115                 120                 125
Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro
    130                 135                 140
Thr Leu Phe Pro Leu Val Ser Cys Glu Asn Ser Pro Ser Asn Thr Ser
145                 150                 155                 160
Ser Val Ala Val Gly Cys Leu Ala Gln Asp Phe Leu
                165                 170

<210> 91
<211> 127
<212> PRT
<213> Homo sapiens

<400> 91
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Leu Ala Ser Gly Phe Thr Phe Glu Asp Tyr
            20                  25                  30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45
Gly Phe Ile Arg Asn Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Val Ile Ser Arg Glu Asp Pro Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Met Arg Tyr Arg Arg Val Pro Ile Phe Gly Gly Ile His Ser
            100                 105                 110
Phe Phe Asp Tyr Trp Gly Leu Gly Thr Leu Val Ser Val Ser Ser
        115                 120                 125

<210> 92
<211> 127
<212> PRT
<213> Homo sapiens

<400> 92
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Phe Pro Thr Pro Gly Tyr Tyr Tyr Asp Ser Ser Gly Tyr
            100                 105                 110
Phe Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 93
<211> 110
<212> PRT
<213> Homo sapiens

<400> 93
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ser Ser Ser Arg Val Ser Asn Phe Asp Tyr Trp
            100                 105                 110

<210> 94
<211> 102
<212> PRT
<213> Homo sapiens

<400> 94
Ser Gly Gly Ala Leu Val His Pro Trp Arg Ser Leu Arg Leu Ser Cys
 1               5                  10                  15
Ser Thr Ser Gly Phe Thr Phe Gly Asp Tyr Ser Met Thr Trp Val Arg
            20                  25                  30
Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ser Ser Ile Arg Gly Lys
        35                  40                  45
Ser Phe Gly Gly Thr Thr Met Tyr Ala Ala Ser Val Lys Asp Arg Phe
    50                  55                  60
Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn
65                  70                  75                  80
Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr Phe Cys Thr Arg Asn Leu
                85                  90                  95
His Asp Phe Asp Tyr Trp
            100

<210> 95
<211> 88
<212> PRT
<213> Homo sapiens

<400> 95
Phe Thr Phe Gly Asp Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly
 1               5                  10                  15
Lys Gly Leu Glu Trp Val Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly
            20                  25                  30
Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
        35                  40                  45
Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr
    50                  55                  60
Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Glu Ser Phe Asp Trp
65                  70                  75                  80
Leu Phe Pro Pro Leu Asp Tyr Trp
                85

<210> 96
<211> 67
<212> PRT
<213> Homo sapiens

<400> 96
Pro Gly Lys Gly Leu Glu Trp Ile Gly Phe Ile Arg Ser Lys Ala Tyr
 1               5                  10                  15
Gly Glu Thr Ala Glu His Ala Ala Ser Val Lys Gly Arg Phe Thr Ile
            20                  25                  30
Ser Arg Asp Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu
        35                  40                  45
Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ser Ser Pro Gly Met
    50                  55                  60
Ala Val Trp
65

<210> 97
<211> 134
<212> PRT
<213> Homo sapiens

<400> 97
Leu Ala Ala Ile Ile Arg Gly Val Gln Cys Glu Val Gln Leu Val Glu
 1               5                  10                  15
Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys
            20                  25                  30
Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Thr Val Ser Trp Leu Arg
        35                  40                  45
Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Gly Phe Ile Arg Ser Lys
    50                  55                  60
Thr His Gly Gly Thr Ala Glu Tyr Ala Ala Ser Leu Asn Gly Arg Phe
65                  70                  75                  80
Thr Ile Ser Arg Glu Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn
                85                  90                  95
Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Ser
            100                 105                 110
Lys Val Asp Gly Lys Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
        115                 120                 125
Met Val Thr Val Ser Ser
    130

<210> 98
<211> 89
<212> PRT
<213> Homo sapiens

<400> 98
Met Ser Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val Gly
 1               5                  10                  15
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
            20                  25                  30
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile Ala
        35                  40                  45
Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr
    50                  55                  60
Cys Thr Arg Glu Ile Glu Gly Tyr Cys Thr Gly Gly Val Cys Phe Lys
65                  70                  75                  80
Thr Thr Arg Asn Ala Phe Asp Ile Trp
                85

<210> 99
<211> 133
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> (1)...(133)
<223> Xaa = Any Amino Acid

<400> 99
Cys Ala Leu Ile Xaa Arg Val Gln Cys Glu Val Gln Leu Val Glu Ser
 1               5                  10                  15
Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr
            20                  25                  30
Ala Ser Gly Phe Thr Phe Gly Asp Tyr Thr Val Ser Trp Leu Arg Gln
        35                  40                  45
Ala Pro Gly Lys Gly Leu Glu Tyr Val Gly Phe Ile Arg Ser Lys Thr
    50                  55                  60
His Gly Gly Thr Ala Glu Tyr Ala Ala Ser Leu Asn Gly Arg Phe Thr
65                  70                  75                  80
Ile Ser Arg Glu Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser
                85                  90                  95
Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Ser Lys
            100                 105                 110
Val Asp Gly Lys Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met
        115                 120                 125
Val Thr Val Ser Ser
    130

<210> 100
<211> 124
<212> PRT
<213> Homo sapiens

<400> 100
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Glu Lys His Tyr Asp Ile Leu Thr Asp Pro Phe Asp
            100                 105                 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 101
<211> 132
<212> PRT
<213> Homo sapiens

<400> 101
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Val Pro Ser Glu Val Leu Pro Ala Ala Met Ala Val
            100                 105                 110
Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val
        115                 120                 125
Thr Val Ser Ser
    130

<210> 102
<211> 114
<212> PRT
<213> Homo sapiens

<400> 102
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Val Tyr Ser Ser Gly Trp Tyr Gly Gly Leu Val Asp
            100                 105                 110
Tyr Trp


<210> 103
<211> 129
<212> PRT
<213> Homo sapiens

<400> 103
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Arg
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Ala Trp Arg Gly Asn Tyr Cys Ser Gly Gly Ser Cys
            100                 105                 110
Tyr Leu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125
Ser


<210> 104
<211> 134
<212> PRT
<213> Homo sapiens

<400> 104
Leu Val Ala Leu Leu Gly Gly Val Gln Cys Glu Val Gln Leu Val Glu
 1               5                  10                  15
Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys
            20                  25                  30
Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr Thr Val Ser Trp Leu Arg
        35                  40                  45
Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val Gly Phe Ile Arg Ser Lys
    50                  55                  60
Thr His Gly Gly Thr Ala Glu Tyr Ala Ala Ser Leu Asn Gly Arg Phe
65                  70                  75                  80
Thr Ile Ser Arg Glu Asp Ser Lys Ser Ile Ala Tyr Leu Gln Met Asn
                85                  90                  95
Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Ser
            100                 105                 110
Lys Val Asp Gly Lys Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
        115                 120                 125
Met Val Thr Val Ser Ser
    130

<210> 105
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide fragment
      

<400> 105
Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr
 1               5                  10                  15
Ala Leu Tyr Tyr Cys
            20

<210> 106
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide fragment general formula
      

<220>
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Ser or Asn

<220>
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Ile, Thr, Ser, Met, Arg, or Asn

<220>
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Ala, Leu, Val, or Gln

<220>
<221> VARIANT        
<222> (9)...(9)
<223> Xaa = Asn, Asp, Ser, Thr or Ala

<220>
<221> VARIANT        
<222> (10)...(10)
<223> Xaa = Ser, Thr, or Asn

<400> 106
Lys Xaa Xaa Xaa Tyr Leu Gln Met Xaa Xaa Leu Lys
 1               5                  10

<210> 107
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Illustrative spacer peptide sequence

<400> 107
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp
 1               5                  10

<210> 108
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Illustrative spacer peptide sequence

<400> 108
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser
 1               5                  10                  15
Leu Asp


<210> 109
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flexible polylinker peptide sequence

<400> 109
Gly Gly Gly Gly Ser
 1               5

<210> 110
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide sequence
      

<400> 110
Glu Val Gln Leu Val Glu
 1               5

<210> 111
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide sequence
      

<400> 111
Asp Val Gln Leu Leu Glu
 1               5


<210> 112
<211> 463
<212> PRT
<213> Homo sapiens

<400> 112
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly
 1               5                  10                  15
Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30
Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ser Ser Gly Phe Thr Phe
        35                  40                  45
Gly Asp Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60
Glu Trp Val Gly Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Glu
65                  70                  75                  80
Tyr Ala Ala Ser Leu Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser
                85                  90                  95
Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr
            100                 105                 110
Ala Leu Tyr Tyr Cys Thr Arg Ser Leu Arg Gly Val Gln Gln Pro Leu
        115                 120                 125
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
    130                 135                 140
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
145                 150                 155                 160
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
                165                 170                 175
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
            180                 185                 190
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
        195                 200                 205
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
    210                 215                 220
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
225                 230                 235                 240
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
                245                 250                 255
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
            260                 265                 270
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
        275                 280                 285
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
    290                 295                 300
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
305                 310                 315                 320
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                325                 330                 335
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Thr Ile
            340                 345                 350
Ser Lys Ala Lys Gly Gly Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
        355                 360                 365
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
    370                 375                 380
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
385                 390                 395                 400
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                405                 410                 415
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
            420                 425                 430
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
        435                 440                 445
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455                 460

<210> 113
<211> 471
<212> PRT
<213> Homo sapiens

<400> 113
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly
 1               5                  10                  15
Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30
Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ser Ser Gly Phe Thr Phe
        35                  40                  45
Gly Asp Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60
Glu Trp Val Gly Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Glu
65                  70                  75                  80
Tyr Ala Ala Ser Leu Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser
                85                  90                  95
Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr
            100                 105                 110
Ala Leu Tyr Tyr Cys Thr Arg Ser Leu Arg Gly Val Gln Gln Pro Leu
        115                 120                 125
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
    130                 135                 140
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
145                 150                 155                 160
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
                165                 170                 175
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
            180                 185                 190
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
        195                 200                 205
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
    210                 215                 220
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
225                 230                 235                 240
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
                245                 250                 255
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
            260                 265                 270
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
        275                 280                 285
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
    290                 295                 300
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
305                 310                 315                 320
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                325                 330                 335
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
            340                 345                 350
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gly Pro Arg
        355                 360                 365
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
    370                 375                 380
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
385                 390                 395                 400
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
                405                 410                 415
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
            420                 425                 430
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
        435                 440                 445
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
    450                 455                 460
Leu Ser Leu Ser Pro Gly Lys
465                 470

<210> 114
<211> 459
<212> PRT
<213> Homo sapiens

<400> 114
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly
 1               5                  10                  15
Val Gln Cys Asp Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30
Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ser Ser Gly Phe Thr Phe
        35                  40                  45
Gly Asp Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60
Glu Trp Val Gly Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Glu
65                  70                  75                  80
Tyr Ala Ala Ser Leu Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser
                85                  90                  95
Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr
            100                 105                 110
Ala Leu Tyr Tyr Cys Thr Arg Ser Leu Arg Gly Val Gln Gln Pro Leu
        115                 120                 125
Asp Tyr Trp Gly Gln Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
    130                 135                 140
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
145                 150                 155                 160
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
                165                 170                 175
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
            180                 185                 190
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
        195                 200                 205
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
    210                 215                 220
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
225                 230                 235                 240
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                245                 250                 255
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
            260                 265                 270
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
        275                 280                 285
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
    290                 295                 300
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
305                 310                 315                 320
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
                325                 330                 335
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            340                 345                 350
Gly Gly Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
        355                 360                 365
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
    370                 375                 380
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
385                 390                 395                 400
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
                405                 410                 415
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
            420                 425                 430
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
        435                 440                 445
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455

<210> 115
<211> 459
<212> PRT
<213> Homo sapiens

<400> 115
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly
 1               5                  10                  15
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30
Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ser Ser Gly Phe Thr Phe
        35                  40                  45
Gly Asp Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60
Glu Trp Val Gly Phe Ile Arg Ser Lys Pro Tyr Gly Gly Thr Thr Glu
65                  70                  75                  80
Tyr Ala Ala Ser Leu Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Ser
                85                  90                  95
Lys Ser Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr
            100                 105                 110
Ala Leu Tyr Tyr Cys Thr Arg Ser Leu Arg Gly Val Gln Gln Pro Leu
        115                 120                 125
Asp Tyr Trp Gly Gln Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
    130                 135                 140
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
145                 150                 155                 160
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
                165                 170                 175
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
            180                 185                 190
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
        195                 200                 205
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
    210                 215                 220
Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
225                 230                 235                 240
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                245                 250                 255
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
            260                 265                 270
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
        275                 280                 285
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
    290                 295                 300
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Tyr Val
305                 310                 315                 320
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
                325                 330                 335
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            340                 345                 350
Gly Gly Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
        355                 360                 365
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
    370                 375                 380
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
385                 390                 395                 400
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
                405                 410                 415
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
            420                 425                 430
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
        435                 440                 445
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455
