                         SEQUENCE LISTING

<110>  Neurotez, Inc
       Tezapsidis, Nikolaos
 
<120>  Mutants and Chimeric Fusion Proteins of Leptin for Treating Alzheimer's Disease

<130>  30888ZY

<140>  13/799,932 
<141>  2013-03-13

<150>  13/439,804
<151>  2012-04-04

<150>  11/516,224
<151>  2006-09-06

<150>  60/714,948
<151>  2005-09-07

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  770
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human APP, isoform a

<400>  1

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210>  2
<211>  751
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human APP, isoform b

<400>  2

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Ile Pro Thr Thr Ala Ala Ser Thr 
            340                 345                 350         


Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp Glu Asn Glu 
        355                 360                 365             


His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg 
    370                 375                 380                 


Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln 
385                 390                 395                 400 


Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe 
                405                 410                 415     


Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln 
            420                 425                 430         


Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu Asn Asp 
        435                 440                 445             


Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln Ala Val 
    450                 455                 460                 


Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr Val Arg 
465                 470                 475                 480 


Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe Glu His Val 
                485                 490                 495     


Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met 
            500                 505                 510         


Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu 
        515                 520                 525             


Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp 
    530                 535                 540                 


Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn 
545                 550                 555                 560 


Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro 
                565                 570                 575     


Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val Asn Gly 
            580                 585                 590         


Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp 
        595                 600                 605             


Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val Asp Ala Arg 
    610                 615                 620                 


Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly Leu Thr 
625                 630                 635                 640 


Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe 
                645                 650                 655     


Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val Phe Phe 
            660                 665                 670         


Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val 
        675                 680                 685             


Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu Val Met Leu 
    690                 695                 700                 


Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val Glu Val Asp 
705                 710                 715                 720 


Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn 
                725                 730                 735     


Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn 
            740                 745                 750     


<210>  3
<211>  695
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human APP, isoform c

<400>  3

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Val Pro Thr Thr Ala Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu 
    290                 295                 300                 


Glu Thr Pro Gly Asp Glu Asn Glu His Ala His Phe Gln Lys Ala Lys 
305                 310                 315                 320 


Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln Val Met Arg 
                325                 330                 335     


Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp 
            340                 345                 350         


Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu 
        355                 360                 365             


Gln Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Thr His Met Ala 
    370                 375                 380                 


Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn 
385                 390                 395                 400 


Tyr Ile Thr Ala Leu Gln Ala Val Pro Pro Arg Pro Arg His Val Phe 
                405                 410                 415     


Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His 
            420                 425                 430         


Thr Leu Lys His Phe Glu His Val Arg Met Val Asp Pro Lys Lys Ala 
        435                 440                 445             


Ala Gln Ile Arg Ser Gln Val Met Thr His Leu Arg Val Ile Tyr Glu 
    450                 455                 460                 


Arg Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala 
465                 470                 475                 480 


Glu Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn 
                485                 490                 495     


Tyr Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser 
            500                 505                 510         


Tyr Gly Asn Asp Ala Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr 
        515                 520                 525             


Val Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln 
    530                 535                 540                 


Pro Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn 
545                 550                 555                 560 


Glu Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr 
                565                 570                 575     


Thr Arg Pro Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser 
            580                 585                 590         


Glu Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val 
        595                 600                 605             


His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys 
    610                 615                 620                 


Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val 
625                 630                 635                 640 


Ile Val Ile Thr Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile 
                645                 650                 655     


His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg 
            660                 665                 670         


His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys 
        675                 680                 685             


Phe Phe Glu Gln Met Gln Asn 
    690                 695 


<210>  4
<211>  40
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  Abeta40

<400>  4

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  5
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  Abeta42

<400>  5

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  6
<211>  43
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  Abeta43

<400>  6

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Ile Ile Lys Gly Ala Ile 
            20                  25                  30          


Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40              


<210>  7
<211>  671
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  sAPPbeta (based on SEQ ID NO: 1)

<400>  7

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met 
            660                 665                 670     


<210>  8
<211>  99
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  10 kda CAPPbeta (C99)

<220>
<221>  MISC_FEATURE
<223>  10 kDa CAPPbeta (C99)

<400>  8

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val 
    50                  55                  60                  


Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys 
65                  70                  75                  80  


Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln 
                85                  90                  95      


Met Gln Asn 
            


<210>  9
<211>  1461
<212>  DNA
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  misc_feature
<223>  SEAP DNA sequence (corresponds to nucleotides 981-2441) of 
       hyg-sa134 vector (SEQ ID NO: 11)

<400>  9
gttgaggagg agaacccgga cttctggaac cgcgaggcag ccgaggccct gggtgccgcc       60

aagaagctgc agcctgcaca gacagccgcc aagaacctca tcatcttcct gggcgatggg      120

atgggggtgt ctacggtgac agctgccagg atcctaaaag ggcagaagaa ggacaaactg      180

gggcctgaga tacccctggc catggaccgc ttcccatatg tggctctgtc caagacatac      240

aatgtagaca aacatgtgcc agacagtgga gccacagcca cggcctacct gtgcggggtc      300

aagggcaact tccagaccat tggcttgagt gcagccgccc gctttaacca gtgcaacacg      360

acacgcggca acgaggtcat ctccgtgatg aatcgggcca agaaagcagg gaagtcagtg      420

ggagtggtaa ccaccacacg agtgcagcac gcctcgccag ccggcaccta cgcccacacg      480

gtgaaccgca actggtactc ggacgccgac gtgcctgcct cggcccgcca ggaggggtgc      540

caggacatcg ctacgcagct catctccaac atggacattg atgtgatcct aggtggaggc      600

cgaaagtaca tgtttcgcat gggaacccca gaccctgagt acccagatga ctacagccaa      660

ggtgggacca ggctggacgg gaagaatctg gtgcaggaat ggctcggcga acgccagggt      720

gcccggtacg tgtggaaccg cactgagctc atgcaggctt ccctggaccc gtctgtgacc      780

catctcatgg gtctctttga gcctggagac atgaaatacg agatccaccg agactccaca      840

ctggacccct ccctgatgga gatgacagag gctgccctgc gcctgctgag cagacacccc      900

cgcggcttct tcctcttcgt ggagggtggt cgcatcgacc atggtcatca tgaaagcagg      960

gcttaccggg cactgactga gacgatcatg ttcgacgacg ccattgagag ggcgggccag     1020

ctcaccagcg aggaggacac gctgagcctc gtcactgccg accactccca cgtcttctcc     1080

ttcggaggct accccctgcg agggagctcc ttcatcgggc tggccgctgg caaggcccgg     1140

gacaggaagg cctacacggt cctcctatac ggaaacggtc caggctatgt gctcaaggac     1200

ggcgcccggc cggatgttac cgagagcgag agcgggagcc ccgagtatcg gcagcagtca     1260

gcagtgcccc tggacgaaga gacccacgca ggcgaggacg tggcggtgtt cgcgcgcggc     1320

ccgcaggcgc acctggttca cggcgtgcag gagcagacct tcatagcgca cgtcatggcc     1380

ttcgccgcct gcctggagcc ctacaccgcc tgcgacctgg cgccccccgc cggcaccacc     1440

gacgccgcgc acccgggttg g                                               1461


<210>  10
<211>  134
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  Amino acid sequence of CAPP134 (amino acid residues 630-770 of 
       human APP, isoform a, SEQ ID NO: 1)

<400>  10

Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr 
1               5                   10                  15      


Arg Pro Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu 
            20                  25                  30          


Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His 
        35                  40                  45              


His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly 
    50                  55                  60                  


Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile 
65                  70                  75                  80  


Val Ile Thr Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His 
                85                  90                  95      


His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His 
            100                 105                 110         


Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe 
        115                 120                 125             


Phe Glu Gln Met Gln Asn 
    130                 


<210>  11
<211>  7506
<212>  DNA
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  misc_feature
<223>  The DNA sequence of the entire hygsa134 vector (with inserts)

<400>  11
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttctgc atgctgctgc tgctgctgct gctgggcctg aggctacagc      960

tctccctggg catcatccta gttgaggagg agaacccgga cttctggaac cgcgaggcag     1020

ccgaggccct gggtgccgcc aagaagctgc agcctgcaca gacagccgcc aagaacctca     1080

tcatcttcct gggcgatggg atgggggtgt ctacggtgac agctgccagg atcctaaaag     1140

ggcagaagaa ggacaaactg gggcctgaga tacccctggc catggaccgc ttcccatatg     1200

tggctctgtc caagacatac aatgtagaca aacatgtgcc agacagtgga gccacagcca     1260

cggcctacct gtgcggggtc aagggcaact tccagaccat tggcttgagt gcagccgccc     1320

gctttaacca gtgcaacacg acacgcggca acgaggtcat ctccgtgatg aatcgggcca     1380

agaaagcagg gaagtcagtg ggagtggtaa ccaccacacg agtgcagcac gcctcgccag     1440

ccggcaccta cgcccacacg gtgaaccgca actggtactc ggacgccgac gtgcctgcct     1500

cggcccgcca ggaggggtgc caggacatcg ctacgcagct catctccaac atggacattg     1560

atgtgatcct aggtggaggc cgaaagtaca tgtttcgcat gggaacccca gaccctgagt     1620

acccagatga ctacagccaa ggtgggacca ggctggacgg gaagaatctg gtgcaggaat     1680

ggctcggcga acgccagggt gcccggtacg tgtggaaccg cactgagctc atgcaggctt     1740

ccctggaccc gtctgtgacc catctcatgg gtctctttga gcctggagac atgaaatacg     1800

agatccaccg agactccaca ctggacccct ccctgatgga gatgacagag gctgccctgc     1860

gcctgctgag cagacacccc cgcggcttct tcctcttcgt ggagggtggt cgcatcgacc     1920

atggtcatca tgaaagcagg gcttaccggg cactgactga gacgatcatg ttcgacgacg     1980

ccattgagag ggcgggccag ctcaccagcg aggaggacac gctgagcctc gtcactgccg     2040

accactccca cgtcttctcc ttcggaggct accccctgcg agggagctcc ttcatcgggc     2100

tggccgctgg caaggcccgg gacaggaagg cctacacggt cctcctatac ggaaacggtc     2160

caggctatgt gctcaaggac ggcgcccggc cggatgttac cgagagcgag agcgggagcc     2220

ccgagtatcg gcagcagtca gcagtgcccc tggacgaaga gacccacgca ggcgaggacg     2280

tggcggtgtt cgcgcgcggc ccgcaggcgc acctggttca cggcgtgcag gagcagacct     2340

tcatagcgca cgtcatggcc ttcgccgcct gcctggagcc ctacaccgcc tgcgacctgg     2400

cgccccccgc cggcaccacc gacgccgcgc acccgggttg gaagatccta gttgagcctg     2460

ttgatgcccg ccctgctgcc gaccgaggac tgaccactcg accaggttct gggttgacaa     2520

atatcaagac ggaggagatc tctgaagtga agatggatgc agaattccga catgactcag     2580

gatatgaagt tcatcatcaa aaattggtgt tctttgcaga agatgtgggt tcaaacaaag     2640

gtgcaatcat tggactcatg gtgggcggtg ttgtcatagc gacagtgatc gtcatcacct     2700

tggtgatgct gaagaagaaa cagtacacat ccattcatca tggtgtggtg gaggttgacg     2760

ccgctgtcac cccagaggag cgccacctgt ccaagatgca gcagaacggc tacgaaaatc     2820

caacctacaa gttctttgag cagatgcaga actagacccc cgccacagca gcctctgaag     2880

ttggacagcc tcgagtctag agggcccgtt taaacccgct gatcagcctc gactgtgcct     2940

tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt     3000

gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg     3060

tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac     3120

aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc     3180

tggggctcta gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg     3240

gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct     3300

ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggc     3360

atccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag     3420

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg     3480

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc     3540

tcggtctatt cttttgattt ataagggatt ttggggattt cggcctattg gttaaaaaat     3600

gagctgattt aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt cagttagggt     3660

gtggaaagtc cccaggctcc ccaggcaggc agaagtatgc aaagcatgca tctcaattag     3720

tcagcaacca ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     3780

catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact     3840

ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag     3900

gccgaggccg cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc     3960

ctaggctttt gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcagcac     4020

gtgatgaaaa agcctgaact caccgcgacg tctgtcgaga agtttctgat cgaaaagttc     4080

gacagcgtct ccgacctgat gcagctctcg gagggcgaag aatctcgtgc tttcagcttc     4140

gatgtaggag ggcgtggata tgtcctgcgg gtaaatagct gcgccgatgg tttctacaaa     4200

gatcgttatg tttatcggca ctttgcatcg gccgcgctcc cgattccgga agtgcttgac     4260

attggggaat tcagcgagag cctgacctat tgcatctccc gccgtgcaca gggtgtcacg     4320

ttgcaagacc tgcctgaaac cgaactgccc gctgttctgc agccggtcgc ggaggccatg     4380

gatgcgatcg ctgcggccga tcttagccag acgagcgggt tcggcccatt cggaccgcaa     4440

ggaatcggtc aatacactac atggcgtgat ttcatatgcg cgattgctga tccccatgtg     4500

tatcactggc aaactgtgat ggacgacacc gtcagtgcgt ccgtcgcgca ggctctcgat     4560

gagctgatgc tttgggccga ggactgcccc gaagtccggc acctcgtgca cgcggatttc     4620

ggctccaaca atgtcctgac ggacaatggc cgcataacag cggtcattga ctggagcgag     4680

gcgatgttcg gggattccca atacgaggtc gccaacatct tcttctggag gccgtggttg     4740

gcttgtatgg agcagcagac gcgctacttc gagcggaggc atccggagct tgcaggatcg     4800

ccgcggctcc gggcgtatat gctccgcatt ggtcttgacc aactctatca gagcttggtt     4860

gacggcaatt tcgatgatgc agcttgggcg cagggtcgat gcgacgcaat cgtccgatcc     4920

ggagccggga ctgtcgggcg tacacaaatc gcccgcagaa gcgcggccgt ctggaccgat     4980

ggctgtgtag aagtactcgc cgatagtgga aaccgacgcc ccagcactcg tccgagggca     5040

aaggaatagc acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc     5100

ttcggaatcg ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg     5160

gagttcttcg cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat     5220

agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc     5280

aaactcatca atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg     5340

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac     5400

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca     5460

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat     5520

taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc     5580

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca     5640

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca     5700

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg     5760

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg     5820

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     5880

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     5940

tctcaatgct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     6000

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     6060

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     6120

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     6180

tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     6240

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt     6300

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct     6360

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta     6420

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     6480

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc     6540

tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact     6600

acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc     6660

tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt     6720

ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta     6780

agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg     6840

tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt     6900

acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc     6960

agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt     7020

actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc     7080

tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc     7140

gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa     7200

ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac     7260

tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa     7320

aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt     7380

tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa     7440

tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct     7500

gacgtc                                                                7506


<210>  12
<211>  440
<212>  DNA
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  misc_feature
<223>  CAPP134 cDNA insert in hygsa134 vector

<400>  12
agttgagcct gttgatgccc gccctgctgc cgaccgagga ctgaccactc gaccaggttc       60

tgggttgaca aatatcaaga cggaggagat ctctgaagtg aagatggatg cagaattccg      120

acatgactca ggatatgaag ttcatcatca aaaattggtg ttctttgcag aagatgtggg      180

ttcaaacaaa ggtgcaatca ttggactcat ggtgggcggt gttgtcatag cgacagtgat      240

cgtcatcacc ttggtgatgc tgaagaagaa acagtacaca tccattcatc atggtgtggt      300

ggaggttgac gccgctgtca ccccagagga gcgccacctg tccaagatgc agcagaacgg      360

ctacgaaaat ccaacctaca agttctttga gcagatgcag aactagaccc ccgccacagc      420

agcctctgaa gttggacagc                                                  440


<210>  13
<211>  770
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  APPswe

<400>  13

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Asn Leu Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210>  14
<211>  467
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  Presenilin 1 (PS1) amino acid sequence (homo sapiens)

<400>  14

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  15
<211>  467
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  PS1M146V : A single mutation at codon 146 co-segregates with the 
       disease in members of  early-onset Alzheimer's disease families. 
       A base pair change from the normal sequence predicts M to V amino
       acid substitution at codon 146.

<400>  15

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Val Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  16
<211>  83
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  8 kDa CAPPalpha (C83)

<400>  16

Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
1               5                   10                  15      


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
            20                  25                  30          


Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val 
        35                  40                  45              


Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys 
    50                  55                  60                  


Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln 
65                  70                  75                  80  


Met Gln Asn 
            


<210>  17
<211>  4154
<212>  DNA
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  misc_feature
<223>  SREBP-1a; SREBP-1 (whole mRNA sequence from Gene Bank Accession 
       No. U00968, GI:409404)

<400>  17
taacgaggaa cttttcgccg gcgccgggcc gcctctgagg ccagggcagg acacgaacgc       60

gcggagcggc ggcggcgact gagagccggg gccgcggcgg cgctccctag gaagggccgt      120

acgaggcggc gggcccggcg ggcctcccgg aggaggcggc tgcgccatgg acgagccacc      180

cttcagcgag gcggctttgg agcaggcgct gggcgagccg tgcgatctgg acgcggcgct      240

gctgaccgac atcgaagaca tgcttcagct tatcaacaac caagacagtg acttccctgg      300

cctatttgac ccaccctatg ctgggagtgg ggcagggggc acagaccctg ccagccccga      360

taccagctcc ccaggcagct tgtctccacc tcctgccaca ttgagctcct ctcttgaagc      420

cttcctgagc gggccgcagg cagcgccctc acccctgtcc cctccccagc ctgcacccac      480

tccattgaag atgtacccgt ccatgcccgc tttctcccct gggcctggta tcaaggaaga      540

gtcagtgcca ctgagcatcc tgcagacccc caccccacag cccctgccag gggccctcct      600

gccacagagc ttcccagccc cagccccacc gcagttcagc tccacccctg tgttaggcta      660

ccccagccct ccgggaggct tctctacagg aagccctccc gggaacaccc agcagccgct      720

gcctggcctg ccactggctt ccccgccagg ggtcccgccc gtctccttgc acacccaggt      780

ccagagtgtg gtcccccagc agctactgac agtcacagct gcccccacgg cagcccctgt      840

aacgaccact gtgacctcgc agatccagca ggtcccggtc ctgctgcagc cccacttcat      900

caaggcagac tcgctgcttc tgacagccat gaagacagac ggagccactg tgaaggcggc      960

aggtctcagt cccctggtct ctggcaccac tgtgcagaca gggcctttgc cgaccctggt     1020

gagtggcgga accatcttgg caacagtccc actggtcgta gatgcggaga agctgcctat     1080

caaccggctc gcagctggca gcaaggcccc ggcctctgcc cagagccgtg gagagaagcg     1140

cacagcccac aacgccattg agaagcgcta ccgctcctcc atcaatgaca aaatcattga     1200

gctcaaggat ctggtggtgg gcactgaggc aaagctgaat aaatctgctg tcttgcgcaa     1260

ggccatcgac tacattcgct ttctgcaaca cagcaaccag aaactcaagc aggagaacct     1320

aagtctgcgc actgctgtcc acaaaagcaa atctctgaag gatctggtgt cggcctgtgg     1380

cagtggaggg aacacagacg tgctcatgga gggcgtgaag actgaggtgg aggacacact     1440

gaccccaccc ccctcggatg ctggctcacc tttccagagc agccccttgt cccttggcag     1500

caggggcagt ggcagcggtg gcagtggcag tgactcggag cctgacagcc cagtctttga     1560

ggacagcaag gcaaagccag agcagcggcc gtctctgcac agccggggca tgctggaccg     1620

ctcccgcctg gccctgtgca cgctcgtctt cctctgcctg tcctgcaacc ccttggcctc     1680

cttgctgggg gcccgggggc ttcccagccc ctcagatacc accagcgtct accatagccc     1740

tgggcgcaac gtgctgggca ccgagagcag agatggccct ggctgggccc agtggctgct     1800

gcccccagtg gtctggctgc tcaatgggct gttggtgctc gtctccttgg tgcttctctt     1860

tgtctacggt gagccagtca cacggcccca ctcaggcccc gccgtgtact tctggaggca     1920

tcgcaagcag gctgacctgg acctggcccg gggagacttt gcccaggctg cccagcagct     1980

gtggctggcc ctgcgggcac tgggccggcc cctgcccacc tcccacctgg acctggcttg     2040

tagcctcctc tggaacctca tccgtcacct gctgcagcgt ctctgggtgg gccgctggct     2100

ggcaggccgg gcagggggcc tgcagcagga ctgtgctctg cgagtggatg ctagcgccag     2160

cgcccgagac gcagccctgg tctaccataa gctgcaccag ctgcacacca tggggaagca     2220

cacaggcggg cacctcactg ccaccaacct ggcgctgagt gccctgaacc tggcagagtg     2280

tgcaggggat gccgtgtctg tggcgacgct ggccgagatc tatgtggcgg ctgcattgag     2340

agtgaagacc agtctcccac gggccttgca ttttctgaca cgcttcttcc tgagcagtgc     2400

ccgccaggcc tgcctggcac agagtggctc agtgcctcct gccatgcagt ggctctgcca     2460

ccccgtgggc caccgtttct tcgtggatgg ggactggtcc gtgctcagta ccccatggga     2520

gagcctgtac agcttggccg ggaacccagt ggaccccctg gcccaggtga ctcagctatt     2580

ccgggaacat ctcttagagc gagcactgaa ctgtgtgacc cagcccaacc ccagccctgg     2640

gtcagctgat ggggacaagg aattctcgga tgccctcggg tacctgcagc tgctgaacag     2700

ctgttctgat gctgcggggg ctcctgccta cagcttctcc atcagttcca gcatggccac     2760

caccaccggc gtagacccgg tggccaagtg gtgggcctct ctgacagctg tggtgatcca     2820

ctggctgcgg cgggatgagg aggcggctga gcggctgtgc ccgctggtgg agcacctgcc     2880

ccgggtgctg caggagtctg agagacccct gcccagggca gctctgcact ccttcaaggc     2940

tgcccgggcc ctgctgggct gtgccaaggc agagtctggt ccagccagcc tgaccatctg     3000

tgagaaggcc agtgggtacc tgcaggacag cctggctacc acaccagcca gcagctccat     3060

tgacaaggcc gtgcagctgt tcctgtgtga cctgcttctt gtggtgcgca ccagcctgtg     3120

gcggcagcag cagcccccgg ccccggcccc agcagcccag ggcgccagca gcaggcccca     3180

ggcttccgcc cttgagctgc gtggcttcca acgggacctg agcagcctga ggcggctggc     3240

acagagcttc cggcccgcca tgcggagggt gttcctacat gaggccacgg cccggctgat     3300

ggcgggggcc agccccacac ggacacacca gctcctcgac cgcagtctga ggcggcgggc     3360

aggccccggt ggcaaaggag gcgcggtggc ggagctggag ccgcggccca cgcggcggga     3420

gcacgcggag gccttgctgc tggcctcctg ctacctgccc cccggcttcc tgtcggcgcc     3480

cgggcagcgc gtgggcatgc tggctgaggc ggcgcgcaca ctcgagaagc ttggcgatcg     3540

ccggctgctg cacgactgtc agcagatgct catgcgcctg ggcggtggga ccactgtcac     3600

ttccagctag accccgtgtc cccggcctca gcacccctgt ctctagccac tttggtcccg     3660

tgcagcttct gtcctgcgtc gaagctttga aggccgaagg cagtgcaaga gactctggcc     3720

tccacagttc gacctgcggc tgctgtgtgc cttcgcggtg gaaggcccga ggggcgcgat     3780

cttgacccta agaccggcgg ccatgatggt gctgacctct ggtggccgat cggggcactg     3840

caggggccga gccattttgg ggggcccccc tccttgctct gcaggcacct tagtggcttt     3900

tttcctcctg tgtacaggga agagaggggt acatttccct gtgctgacgg aagccaactt     3960

ggctttcccg gactgcaagc agggctctgc cccagaggcc tctctctccg tcgtgggaga     4020

gagacgtgta catagtgtag gtcagcgtgc ttagcctcct gacctgaggc tcctgtgcta     4080

ctttgccttt tgcaaacttt attttcatag attgagaagt tttgtacaga gaattaaaaa     4140

tgaaattatt tata                                                       4154


<210>  18
<211>  1123
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  SREBP-1c amino acid sequence; identical to SREBP-1a (SEQ ID NO: 
       24) except for amino acid residues 1-6 of SREBP-1c (from SREBP-1c
       specific exon) differ from residues 1-30 of SREBP-1a (SEQ ID NO: 
       24)

<400>  18

Met Asp Cys Thr Phe Glu Asp Met Leu Gln Leu Ile Asn Asn Gln Asp 
1               5                   10                  15      


Ser Asp Phe Pro Gly Leu Phe Asp Pro Pro Tyr Ala Gly Ser Gly Ala 
            20                  25                  30          


Gly Gly Thr Asp Pro Ala Ser Pro Asp Thr Ser Ser Pro Gly Ser Leu 
        35                  40                  45              


Ser Pro Pro Pro Ala Thr Leu Ser Ser Ser Leu Glu Ala Phe Leu Ser 
    50                  55                  60                  


Gly Pro Gln Ala Ala Pro Ser Pro Leu Ser Pro Pro Gln Pro Ala Pro 
65                  70                  75                  80  


Thr Pro Leu Lys Met Tyr Pro Ser Met Pro Ala Phe Ser Pro Gly Pro 
                85                  90                  95      


Gly Ile Lys Glu Glu Ser Val Pro Leu Ser Ile Leu Gln Thr Pro Thr 
            100                 105                 110         


Pro Gln Pro Leu Pro Gly Ala Leu Leu Pro Gln Ser Phe Pro Ala Pro 
        115                 120                 125             


Ala Pro Pro Gln Phe Ser Ser Thr Pro Val Leu Gly Tyr Pro Ser Pro 
    130                 135                 140                 


Pro Gly Gly Phe Ser Thr Gly Ser Pro Pro Gly Asn Thr Gln Gln Pro 
145                 150                 155                 160 


Leu Pro Gly Leu Pro Leu Ala Ser Pro Pro Gly Val Pro Pro Val Ser 
                165                 170                 175     


Leu His Thr Gln Val Gln Ser Val Val Pro Gln Gln Leu Leu Thr Val 
            180                 185                 190         


Thr Ala Ala Pro Thr Ala Ala Pro Val Thr Thr Thr Val Thr Ser Gln 
        195                 200                 205             


Ile Gln Gln Val Pro Val Leu Leu Gln Pro His Phe Ile Lys Ala Asp 
    210                 215                 220                 


Ser Leu Leu Leu Thr Ala Met Lys Thr Asp Gly Ala Thr Val Lys Ala 
225                 230                 235                 240 


Ala Gly Leu Ser Pro Leu Val Ser Gly Thr Thr Val Gln Thr Gly Pro 
                245                 250                 255     


Leu Pro Thr Leu Val Ser Gly Gly Thr Ile Leu Ala Thr Val Pro Leu 
            260                 265                 270         


Val Val Asp Ala Glu Lys Leu Pro Ile Asn Arg Leu Ala Ala Gly Ser 
        275                 280                 285             


Lys Ala Pro Ala Ser Ala Gln Ser Arg Gly Glu Lys Arg Thr Ala His 
    290                 295                 300                 


Asn Ala Ile Glu Lys Arg Tyr Arg Ser Ser Ile Asn Asp Lys Ile Ile 
305                 310                 315                 320 


Glu Leu Lys Asp Leu Val Val Gly Thr Glu Ala Lys Leu Asn Lys Ser 
                325                 330                 335     


Ala Val Leu Arg Lys Ala Ile Asp Tyr Ile Arg Phe Leu Gln His Ser 
            340                 345                 350         


Asn Gln Lys Leu Lys Gln Glu Asn Leu Ser Leu Arg Thr Ala Val His 
        355                 360                 365             


Lys Ser Lys Ser Leu Lys Asp Leu Val Ser Ala Cys Gly Ser Gly Gly 
    370                 375                 380                 


Asn Thr Asp Val Leu Met Glu Gly Val Lys Thr Glu Val Glu Asp Thr 
385                 390                 395                 400 


Leu Thr Pro Pro Pro Ser Asp Ala Gly Ser Pro Phe Gln Ser Ser Pro 
                405                 410                 415     


Leu Ser Leu Gly Ser Arg Gly Ser Gly Ser Gly Gly Ser Gly Ser Asp 
            420                 425                 430         


Ser Glu Pro Asp Ser Pro Val Phe Glu Asp Ser Lys Ala Lys Pro Glu 
        435                 440                 445             


Gln Arg Pro Ser Leu His Ser Arg Gly Met Leu Asp Arg Ser Arg Leu 
    450                 455                 460                 


Ala Leu Cys Thr Leu Val Phe Leu Cys Leu Ser Cys Asn Pro Leu Ala 
465                 470                 475                 480 


Ser Leu Leu Gly Ala Arg Gly Leu Pro Ser Pro Ser Asp Thr Thr Ser 
                485                 490                 495     


Val Tyr His Ser Pro Gly Arg Asn Val Leu Gly Thr Glu Ser Arg Asp 
            500                 505                 510         


Gly Pro Gly Trp Ala Gln Trp Leu Leu Pro Pro Val Val Trp Leu Leu 
        515                 520                 525             


Asn Gly Leu Leu Val Leu Val Ser Leu Val Leu Leu Phe Val Tyr Gly 
    530                 535                 540                 


Glu Pro Val Thr Arg Pro His Ser Gly Pro Ala Val Tyr Phe Trp Arg 
545                 550                 555                 560 


His Arg Lys Gln Ala Asp Leu Asp Leu Ala Arg Gly Asp Phe Ala Gln 
                565                 570                 575     


Ala Ala Gln Gln Leu Trp Leu Ala Leu Arg Ala Leu Gly Arg Pro Leu 
            580                 585                 590         


Pro Thr Ser His Leu Asp Leu Ala Cys Ser Leu Leu Trp Asn Leu Ile 
        595                 600                 605             


Arg His Leu Leu Gln Arg Leu Trp Val Gly Arg Trp Leu Ala Gly Arg 
    610                 615                 620                 


Ala Gly Gly Leu Gln Gln Asp Cys Ala Leu Arg Val Asp Ala Ser Ala 
625                 630                 635                 640 


Ser Ala Arg Asp Ala Ala Leu Val Tyr His Lys Leu His Gln Leu His 
                645                 650                 655     


Thr Met Gly Lys His Thr Gly Gly His Leu Thr Ala Thr Asn Leu Ala 
            660                 665                 670         


Leu Ser Ala Leu Asn Leu Ala Glu Cys Ala Gly Asp Ala Val Ser Val 
        675                 680                 685             


Ala Thr Leu Ala Glu Ile Tyr Val Ala Ala Ala Leu Arg Val Lys Thr 
    690                 695                 700                 


Ser Leu Pro Arg Ala Leu His Phe Leu Thr Arg Phe Phe Leu Ser Ser 
705                 710                 715                 720 


Ala Arg Gln Ala Cys Leu Ala Gln Ser Gly Ser Val Pro Pro Ala Met 
                725                 730                 735     


Gln Trp Leu Cys His Pro Val Gly His Arg Phe Phe Val Asp Gly Asp 
            740                 745                 750         


Trp Ser Val Leu Ser Thr Pro Trp Glu Ser Leu Tyr Ser Leu Ala Gly 
        755                 760                 765             


Asn Pro Val Asp Pro Leu Ala Gln Val Thr Gln Leu Phe Arg Glu His 
    770                 775                 780                 


Leu Leu Glu Arg Ala Leu Asn Cys Val Thr Gln Pro Asn Pro Ser Pro 
785                 790                 795                 800 


Gly Ser Ala Asp Gly Asp Lys Glu Phe Ser Asp Ala Leu Gly Tyr Leu 
                805                 810                 815     


Gln Leu Leu Asn Ser Cys Ser Asp Ala Ala Gly Ala Pro Ala Tyr Ser 
            820                 825                 830         


Phe Ser Ile Ser Ser Ser Met Ala Thr Thr Thr Gly Val Asp Pro Val 
        835                 840                 845             


Ala Lys Trp Trp Ala Ser Leu Thr Ala Val Val Ile His Trp Leu Arg 
    850                 855                 860                 


Arg Asp Glu Glu Ala Ala Glu Arg Leu Cys Pro Leu Val Glu His Leu 
865                 870                 875                 880 


Pro Arg Val Leu Gln Glu Ser Glu Arg Pro Leu Pro Arg Ala Ala Leu 
                885                 890                 895     


His Ser Phe Lys Ala Ala Arg Ala Leu Leu Gly Cys Ala Lys Ala Glu 
            900                 905                 910         


Ser Gly Pro Ala Ser Leu Thr Ile Cys Glu Lys Ala Ser Gly Tyr Leu 
        915                 920                 925             


Gln Asp Ser Leu Ala Thr Thr Pro Ala Ser Ser Ser Ile Asp Lys Ala 
    930                 935                 940                 


Val Gln Leu Phe Leu Cys Asp Leu Leu Leu Val Val Arg Thr Ser Leu 
945                 950                 955                 960 


Trp Arg Gln Gln Gln Pro Pro Ala Pro Ala Pro Ala Ala Gln Gly Ala 
                965                 970                 975     


Ser Ser Arg Pro Gln Ala Ser Ala Leu Glu Leu Arg Gly Phe Gln Arg 
            980                 985                 990         


Asp Leu Ser Ser Leu Arg Arg Leu  Ala Gln Ser Phe Arg  Pro Ala Met 
        995                 1000                 1005             


Arg Arg  Val Phe Leu His Glu  Ala Thr Ala Arg Leu  Met Ala Gly 
    1010                 1015                 1020             


Ala Ser  Pro Thr Arg Thr His  Gln Leu Leu Asp Arg  Ser Leu Arg 
    1025                 1030                 1035             


Arg Arg  Ala Gly Pro Gly Gly  Lys Gly Gly Ala Val  Ala Glu Leu 
    1040                 1045                 1050             


Glu Pro  Arg Pro Thr Arg Arg  Glu His Ala Glu Ala  Leu Leu Leu 
    1055                 1060                 1065             


Ala Ser  Cys Tyr Leu Pro Pro  Gly Phe Leu Ser Ala  Pro Gly Gln 
    1070                 1075                 1080             


Arg Val  Gly Met Leu Ala Glu  Ala Ala Arg Thr Leu  Glu Lys Leu 
    1085                 1090                 1095             


Gly Asp  Arg Arg Leu Leu His  Asp Cys Gln Gln Met  Leu Met Arg 
    1100                 1105                 1110             


Leu Gly  Gly Gly Thr Thr Val  Thr Ser Ser 
    1115                 1120             


<210>  19
<211>  4249
<212>  DNA
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  misc_feature
<223>  SREBP-2; whole mRNA sequence from Genbank Accession No. U02031, 
       GI:451329; CDS 118...3543; for cloning in pcDNA3.1, see SEQ ID 
       NOs. 22 and 23

<220>
<221>  misc_feature
<223>  SREBP-2; whole mRNA sequence from Genbank Accession No. U02031, 
       GI:451329; CDS 118...3543

<400>  19
ccgtcggtga ggcggtgccg ggcgggggtt gtcgggtgtc atgggcggtg gcgacggcac       60

cgcccccgcg tctccctgag cgggacggca gggggggctt ctgcgctgag ccgggcgatg      120

gacgacagcg gcgagctggg tggtctggag accatggaga ccctcacgga gctgggcgac      180

gagctgaccc tgggagacat cgacgagatg ctgcaatttg tcagtaatca agtgggagag      240

ttccctgact tgttttcaga acagctgtgt agctcctttc ctggcagtgg tggtagtggt      300

agcagcagcg gcagcagtgg cagcagcagc agcagcagca atggcagggg cagcagcagc      360

ggagctgtgg acccttcagt gcaacggtca ttcacccagg tcacattacc ttccttctct      420

ccctcggcgg cctccccaca ggctccaact ctgcaagtca aggtttctcc cacctcagtt      480

cccaccacac ccagggcaac tcctattctt cagccccgcc cccagcccca gcctcaacct      540

caaactcagc tgcaacaaca gacggtaatg atcacgccaa cattcagcac cactccgcag      600

acgaggatca tccagcagcc tttgatatac cagaatgcag ctactagctt tcaagtcctt      660

cagcctcaag tccaaagcct ggtgacatcc tcccaggtac agccggtcac cattcagcag      720

caggtgcaga cagtacaggc ccagcgggtg ctgacacaaa cggccaatgg cacgctgcag      780

acccttgccc cggctacggt gcagacagtt gctgcgccac aggtgcagca ggtcccggtc      840

ctggtccagc ctcagatcat caagacagat tcccttgttt tgaccacact gaagacagat      900

ggcagccctg ttatggctgc ggtccagaac ccggccctca ccgccctcac cacccctatc      960

cagacggctg cccttcaagt accaaccctg gtgggcagca gtgggaccat tctgaccaca     1020

atgcctgtaa tgatggggca agagaaagtg cccattaagc aggtacctgg gggagtcaag     1080

cagcttgagc cccccaaaga aggagaaagg cggacaaccc ataatatcat tgagaaacga     1140

tatcgctcct ccatcaatga caaaatcatc gaattgaaag acctggtcat ggggacagac     1200

gccaagatgc acaagtctgg cgttctgagg aaggccattg attacatcaa atacttgcag     1260

caggtcaatc ataaactgcg ccaggagaac atggtgctga agctggcaaa tcaaaagaac     1320

aagcttctaa agggcatcga cctaggcagt ctggtggaca atgaggtgga cctgaagatc     1380

gaggacttta atcagaatgt ccttctgatg tcccccccag cctctgactc agggtcccag     1440

gctggcttct ctccctactc cattgactct gagccaggaa gccctctatt ggatgatgca     1500

aaggtcaaag atgagccaga ctctcctcct gtggcgctgg gcatggtaga ccgctcacgg     1560

attcttctgt gtgtcctcac cttcctgtgc ctctccttta accccctgac ttccctgctg     1620

cagtggggag gggcccacga ctctgaccag cacccacact caggctctgg ccgcagtgtc     1680

ctgtcattcg agtcaggttc tgggggctgg tttgactgga tgatgcctac tcttctctta     1740

tggctggtaa atggtgtgat tgtcctgagc gtctttgtga agctgctggt tcatggggag     1800

ccagtgatcc ggccacactc gcgctcctcg gtcaccttct ggaggcaccg gaaacaggca     1860

gatctggatc tcgccagagg agattttgca gctgctgccg ccaacctaca aacctgcctg     1920

gcagttttgg gccgggcact gcccacctcc cgcctggacc tggcctgcag cctctcctgg     1980

aacgtgatcc gctacagcct gcagaagcta cgcctggtgc gctggctgct caagaaagtc     2040

ttccagtgcc ggcgggccac gccagccact gaggcaggct ttgaagacga agctaagacc     2100

agcgcccggg atgcggctct ggcctatcac cggctgcacc agctgcacat cacagggaag     2160

cttcctgcag gatccgcctg ttccgatgta cacatggcgt tgtgtgccgt gaacctggct     2220

gaatgtgcag aggagaagat cccaccgagc acactggttg agatccatct gactgctgcc     2280

atggggctca agacccggtg tggaggcaag ctgggcttcc tggccagcta cttcctcagc     2340

cgagcccaga gcctgtgtgg ccccgagcac agtgctgttc ctgactccct gcgctggctc     2400

tgccaccccc tgggccagaa gtttttcatg gagcggagct ggtctgtgaa gtcagctgcc     2460

aaggagagtc tatactgtgc ccagaggaac ccagctgacc ccattgcgca ggtccaccag     2520

gccttctgca agaacctgct ggagcgagct atagagtcct tggtgaaacc tcaggccaag     2580

aagaaggctg gagaccagga agaagagagc tgtgaattct ccagtgctct ggagtacttg     2640

aaattacttc attcttttgt ggactctgtg ggggttatga gccccccact ctccaggagc     2700

tccgtgctca agtccgccct gggtccagac atcatctgtc ggtggtggac gtctgcaatc     2760

actgtggcca tcagctggct ccagggagac gatgcagctg tgcgctctca ttttaccaaa     2820

gtggaacgca tccccaaggc cctggaagtg acagagagcc ccctggtgaa ggccatcttc     2880

catgcctgca gagccatgca tgcctcactc cctgggaaag cagatgggca gcagagttcc     2940

ttctgccatt gcgagagggc cagtggccac ctatggagca gcctcaacgt cagtgggggc     3000

acctctgacc ctgccctcaa ccacgtggtc cagctgctca cctgtgacct gctactgtcg     3060

ctacggacag cgctctggca aaaacaggcc agtgccagcc aggctgtggg ggagacctac     3120

cacgcgtcag gcgctgaact ggcgggcttc caacgggacc tgggcagcct gcgcaggctg     3180

gcacacagct tccgcccagc ataccgcaag gtgttcctgc atgaagccac cgtgcgcctg     3240

atggcaggag gcagccccac ccgcacccac cagctgctgg aacacagcct gcggcggcgc     3300

accacgcaga gcaccaagca cggagaggtg gatgcctggc ccggccagcg agagcgggcc     3360

accgccatcc tgctggcctg ccgccacctg cccctctcct tcctctcctc cccgggccag     3420

cgggcagtgc tgctggccga agctgcccgc accctggaga aggtgggcga ccggcgctcc     3480

tgcaacgact gccagcagat gattgttaag ctgggtggtg gcactgccat tgccgcctcc     3540

tgaccaccag gctcagccca cccctccacc tctctctcga tttctctctc tccccctcag     3600

catcttcccg ctgagagtgg tggggaagag ccttgtcttc ttagctgtca cctgccgagg     3660

cttctgggcc actcaggcca gtgcacccct gggcagagcc ccttaaagct gctgtcacta     3720

gatgcccatg gtccagggcc tggtgggcgt gagaggatag gtggcagggc agaaactggg     3780

cagccctgac ttgatagcag cagggggagc tcccaagctg ccaagcccct gcctccagcc     3840

ttcctgagtt tctctctcct gaaccctact ctctcctttt tgcttcctca gtttttatca     3900

ggctttctct gggggacagc agtctctgag caccagggag cagttgccct caggcctgtg     3960

cccagcatgc cctccccttt ttatacgaat gttttctacc agtgtgcttg ggtttgccat     4020

gatgcgaggc tgagttgctg tagcgtcttg attctctccc tgggtctgcg ttccctcccc     4080

tgggcctgac tgagcctgct cattgttttt ccctttatta cacaggacag ccaggggagg     4140

aggggggccc agccctggga ggctggtggg aggcaggggg caggcctgcg gatgcatgaa     4200

ataatgttgg cattattttt taatttttta aaaaataaat ggtatctta                 4249


<210>  20
<211>  28
<212>  DNA
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  misc_feature
<223>  SREBP-1 forward primer; BamHI site at nucleotides 5-10; target 
       sequence at nucleotides 13-28

<400>  20
gagaggatcc aacagggcag gacacgaa                                          28


<210>  21
<211>  28
<212>  DNA
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  misc_feature
<223>  SREBP-1 reverse primer; EcoRI site at nucleotides 5-10; target 
       sequence at nucleotides 13-28

<400>  21
gagagaattc ggctgctgcc aagggaca                                          28


<210>  22
<211>  29
<212>  DNA
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  misc_feature
<223>  SREBP-2 forward primer; BamHI site at nucleotides 5-10; target 
       sequence at nucleotides 13-29

<400>  22
gagaggatcc aaggttgtcg ggtgtcatg                                         29


<210>  23
<211>  31
<212>  DNA
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  misc_feature
<223>  SREBP-2 reverse primer; EcoRI site at nucleotides 5-10; target 
       sequence at nucleotides 13-31

<400>  23
gagagaattc ggctggctca tctttgacct t                                      31


<210>  24
<211>  1147
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  Whole SREBP-1 protein amino-acid sequence shown. The PCR product 
       generates an NH2-terminal fragment of SREBP-1 (amino acid 
       residues 1-445), a dominant positive fragment of SREBP-1

<400>  24

Met Asp Glu Pro Pro Phe Ser Glu Ala Ala Leu Glu Gln Ala Leu Gly 
1               5                   10                  15      


Glu Pro Cys Asp Leu Asp Ala Ala Leu Leu Thr Asp Ile Glu Asp Met 
            20                  25                  30          


Leu Gln Leu Ile Asn Asn Gln Asp Ser Asp Phe Pro Gly Leu Phe Asp 
        35                  40                  45              


Pro Pro Tyr Ala Gly Ser Gly Ala Gly Gly Thr Asp Pro Ala Ser Pro 
    50                  55                  60                  


Asp Thr Ser Ser Pro Gly Ser Leu Ser Pro Pro Pro Ala Thr Leu Ser 
65                  70                  75                  80  


Ser Ser Leu Glu Ala Phe Leu Ser Gly Pro Gln Ala Ala Pro Ser Pro 
                85                  90                  95      


Leu Ser Pro Pro Gln Pro Ala Pro Thr Pro Leu Lys Met Tyr Pro Ser 
            100                 105                 110         


Met Pro Ala Phe Ser Pro Gly Pro Gly Ile Lys Glu Glu Ser Val Pro 
        115                 120                 125             


Leu Ser Ile Leu Gln Thr Pro Thr Pro Gln Pro Leu Pro Gly Ala Leu 
    130                 135                 140                 


Leu Pro Gln Ser Phe Pro Ala Pro Ala Pro Pro Gln Phe Ser Ser Thr 
145                 150                 155                 160 


Pro Val Leu Gly Tyr Pro Ser Pro Pro Gly Gly Phe Ser Thr Gly Ser 
                165                 170                 175     


Pro Pro Gly Asn Thr Gln Gln Pro Leu Pro Gly Leu Pro Leu Ala Ser 
            180                 185                 190         


Pro Pro Gly Val Pro Pro Val Ser Leu His Thr Gln Val Gln Ser Val 
        195                 200                 205             


Val Pro Gln Gln Leu Leu Thr Val Thr Ala Ala Pro Thr Ala Ala Pro 
    210                 215                 220                 


Val Thr Thr Thr Val Thr Ser Gln Ile Gln Gln Val Pro Val Leu Leu 
225                 230                 235                 240 


Gln Pro His Phe Ile Lys Ala Asp Ser Leu Leu Leu Thr Ala Met Lys 
                245                 250                 255     


Thr Asp Gly Ala Thr Val Lys Ala Ala Gly Leu Ser Pro Leu Val Ser 
            260                 265                 270         


Gly Thr Thr Val Gln Thr Gly Pro Leu Pro Thr Leu Val Ser Gly Gly 
        275                 280                 285             


Thr Ile Leu Ala Thr Val Pro Leu Val Val Asp Ala Glu Lys Leu Pro 
    290                 295                 300                 


Ile Asn Arg Leu Ala Ala Gly Ser Lys Ala Pro Ala Ser Ala Gln Ser 
305                 310                 315                 320 


Arg Gly Glu Lys Arg Thr Ala His Asn Ala Ile Glu Lys Arg Tyr Arg 
                325                 330                 335     


Ser Ser Ile Asn Asp Lys Ile Ile Glu Leu Lys Asp Leu Val Val Gly 
            340                 345                 350         


Thr Glu Ala Lys Leu Asn Lys Ser Ala Val Leu Arg Lys Ala Ile Asp 
        355                 360                 365             


Tyr Ile Arg Phe Leu Gln His Ser Asn Gln Lys Leu Lys Gln Glu Asn 
    370                 375                 380                 


Leu Ser Leu Arg Thr Ala Val His Lys Ser Lys Ser Leu Lys Asp Leu 
385                 390                 395                 400 


Val Ser Ala Cys Gly Ser Gly Gly Asn Thr Asp Val Leu Met Glu Gly 
                405                 410                 415     


Val Lys Thr Glu Val Glu Asp Thr Leu Thr Pro Pro Pro Ser Asp Ala 
            420                 425                 430         


Gly Ser Pro Phe Gln Ser Ser Pro Leu Ser Leu Gly Ser Arg Gly Ser 
        435                 440                 445             


Gly Ser Gly Gly Ser Gly Ser Asp Ser Glu Pro Asp Ser Pro Val Phe 
    450                 455                 460                 


Glu Asp Ser Lys Ala Lys Pro Glu Gln Arg Pro Ser Leu His Ser Arg 
465                 470                 475                 480 


Gly Met Leu Asp Arg Ser Arg Leu Ala Leu Cys Thr Leu Val Phe Leu 
                485                 490                 495     


Cys Leu Ser Cys Asn Pro Leu Ala Ser Leu Leu Gly Ala Arg Gly Leu 
            500                 505                 510         


Pro Ser Pro Ser Asp Thr Thr Ser Val Tyr His Ser Pro Gly Arg Asn 
        515                 520                 525             


Val Leu Gly Thr Glu Ser Arg Asp Gly Pro Gly Trp Ala Gln Trp Leu 
    530                 535                 540                 


Leu Pro Pro Val Val Trp Leu Leu Asn Gly Leu Leu Val Leu Val Ser 
545                 550                 555                 560 


Leu Val Leu Leu Phe Val Tyr Gly Glu Pro Val Thr Arg Pro His Ser 
                565                 570                 575     


Gly Pro Ala Val Tyr Phe Trp Arg His Arg Lys Gln Ala Asp Leu Asp 
            580                 585                 590         


Leu Ala Arg Gly Asp Phe Ala Gln Ala Ala Gln Gln Leu Trp Leu Ala 
        595                 600                 605             


Leu Arg Ala Leu Gly Arg Pro Leu Pro Thr Ser His Leu Asp Leu Ala 
    610                 615                 620                 


Cys Ser Leu Leu Trp Asn Leu Ile Arg His Leu Leu Gln Arg Leu Trp 
625                 630                 635                 640 


Val Gly Arg Trp Leu Ala Gly Arg Ala Gly Gly Leu Gln Gln Asp Cys 
                645                 650                 655     


Ala Leu Arg Val Asp Ala Ser Ala Ser Ala Arg Asp Ala Ala Leu Val 
            660                 665                 670         


Tyr His Lys Leu His Gln Leu His Thr Met Gly Lys His Thr Gly Gly 
        675                 680                 685             


His Leu Thr Ala Thr Asn Leu Ala Leu Ser Ala Leu Asn Leu Ala Glu 
    690                 695                 700                 


Cys Ala Gly Asp Ala Val Ser Val Ala Thr Leu Ala Glu Ile Tyr Val 
705                 710                 715                 720 


Ala Ala Ala Leu Arg Val Lys Thr Ser Leu Pro Arg Ala Leu His Phe 
                725                 730                 735     


Leu Thr Arg Phe Phe Leu Ser Ser Ala Arg Gln Ala Cys Leu Ala Gln 
            740                 745                 750         


Ser Gly Ser Val Pro Pro Ala Met Gln Trp Leu Cys His Pro Val Gly 
        755                 760                 765             


His Arg Phe Phe Val Asp Gly Asp Trp Ser Val Leu Ser Thr Pro Trp 
    770                 775                 780                 


Glu Ser Leu Tyr Ser Leu Ala Gly Asn Pro Val Asp Pro Leu Ala Gln 
785                 790                 795                 800 


Val Thr Gln Leu Phe Arg Glu His Leu Leu Glu Arg Ala Leu Asn Cys 
                805                 810                 815     


Val Thr Gln Pro Asn Pro Ser Pro Gly Ser Ala Asp Gly Asp Lys Glu 
            820                 825                 830         


Phe Ser Asp Ala Leu Gly Tyr Leu Gln Leu Leu Asn Ser Cys Ser Asp 
        835                 840                 845             


Ala Ala Gly Ala Pro Ala Tyr Ser Phe Ser Ile Ser Ser Ser Met Ala 
    850                 855                 860                 


Thr Thr Thr Gly Val Asp Pro Val Ala Lys Trp Trp Ala Ser Leu Thr 
865                 870                 875                 880 


Ala Val Val Ile His Trp Leu Arg Arg Asp Glu Glu Ala Ala Glu Arg 
                885                 890                 895     


Leu Cys Pro Leu Val Glu His Leu Pro Arg Val Leu Gln Glu Ser Glu 
            900                 905                 910         


Arg Pro Leu Pro Arg Ala Ala Leu His Ser Phe Lys Ala Ala Arg Ala 
        915                 920                 925             


Leu Leu Gly Cys Ala Lys Ala Glu Ser Gly Pro Ala Ser Leu Thr Ile 
    930                 935                 940                 


Cys Glu Lys Ala Ser Gly Tyr Leu Gln Asp Ser Leu Ala Thr Thr Pro 
945                 950                 955                 960 


Ala Ser Ser Ser Ile Asp Lys Ala Val Gln Leu Phe Leu Cys Asp Leu 
                965                 970                 975     


Leu Leu Val Val Arg Thr Ser Leu Trp Arg Gln Gln Gln Pro Pro Ala 
            980                 985                 990         


Pro Ala Pro Ala Ala Gln Gly Ala  Ser Ser Arg Pro Gln  Ala Ser Ala 
        995                 1000                 1005             


Leu Glu  Leu Arg Gly Phe Gln  Arg Asp Leu Ser Ser  Leu Arg Arg 
    1010                 1015                 1020             


Leu Ala  Gln Ser Phe Arg Pro  Ala Met Arg Arg Val  Phe Leu His 
    1025                 1030                 1035             


Glu Ala  Thr Ala Arg Leu Met  Ala Gly Ala Ser Pro  Thr Arg Thr 
    1040                 1045                 1050             


His Gln  Leu Leu Asp Arg Ser  Leu Arg Arg Arg Ala  Gly Pro Gly 
    1055                 1060                 1065             


Gly Lys  Gly Gly Ala Val Ala  Glu Leu Glu Pro Arg  Pro Thr Arg 
    1070                 1075                 1080             


Arg Glu  His Ala Glu Ala Leu  Leu Leu Ala Ser Cys  Tyr Leu Pro 
    1085                 1090                 1095             


Pro Gly  Phe Leu Ser Ala Pro  Gly Gln Arg Val Gly  Met Leu Ala 
    1100                 1105                 1110             


Glu Ala  Ala Arg Thr Leu Glu  Lys Leu Gly Asp Arg  Arg Leu Leu 
    1115                 1120                 1125             


His Asp  Cys Gln Gln Met Leu  Met Arg Leu Gly Gly  Gly Thr Thr 
    1130                 1135                 1140             


Val Thr  Ser Ser 
    1145         


<210>  25
<211>  1141
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  Whole SREBP-1 protein amino-acid sequence shown. The PCR product 
       generates an NH2-terminal fragment of SREBP-1 (amino acid 
       residues 1-445), a dominant positive fragment of SREBP-1

<400>  25

Met Asp Asp Ser Gly Glu Leu Gly Gly Leu Glu Thr Met Glu Thr Leu 
1               5                   10                  15      


Thr Glu Leu Gly Asp Glu Leu Thr Leu Gly Asp Ile Asp Glu Met Leu 
            20                  25                  30          


Gln Phe Val Ser Asn Gln Val Gly Glu Phe Pro Asp Leu Phe Ser Glu 
        35                  40                  45              


Gln Leu Cys Ser Ser Phe Pro Gly Ser Gly Gly Ser Gly Ser Ser Ser 
    50                  55                  60                  


Gly Ser Ser Gly Ser Ser Ser Ser Ser Ser Asn Gly Arg Gly Ser Ser 
65                  70                  75                  80  


Ser Gly Ala Val Asp Pro Ser Val Gln Arg Ser Phe Thr Gln Val Thr 
                85                  90                  95      


Leu Pro Ser Phe Ser Pro Ser Ala Ala Ser Pro Gln Ala Pro Thr Leu 
            100                 105                 110         


Gln Val Lys Val Ser Pro Thr Ser Val Pro Thr Thr Pro Arg Ala Thr 
        115                 120                 125             


Pro Ile Leu Gln Pro Arg Pro Gln Pro Gln Pro Gln Pro Gln Thr Gln 
    130                 135                 140                 


Leu Gln Gln Gln Thr Val Met Ile Thr Pro Thr Phe Ser Thr Thr Pro 
145                 150                 155                 160 


Gln Thr Arg Ile Ile Gln Gln Pro Leu Ile Tyr Gln Asn Ala Ala Thr 
                165                 170                 175     


Ser Phe Gln Val Leu Gln Pro Gln Val Gln Ser Leu Val Thr Ser Ser 
            180                 185                 190         


Gln Val Gln Pro Val Thr Ile Gln Gln Gln Val Gln Thr Val Gln Ala 
        195                 200                 205             


Gln Arg Val Leu Thr Gln Thr Ala Asn Gly Thr Leu Gln Thr Leu Ala 
    210                 215                 220                 


Pro Ala Thr Val Gln Thr Val Ala Ala Pro Gln Val Gln Gln Val Pro 
225                 230                 235                 240 


Val Leu Val Gln Pro Gln Ile Ile Lys Thr Asp Ser Leu Val Leu Thr 
                245                 250                 255     


Thr Leu Lys Thr Asp Gly Ser Pro Val Met Ala Ala Val Gln Asn Pro 
            260                 265                 270         


Ala Leu Thr Ala Leu Thr Thr Pro Ile Gln Thr Ala Ala Leu Gln Val 
        275                 280                 285             


Pro Thr Leu Val Gly Ser Ser Gly Thr Ile Leu Thr Thr Met Pro Val 
    290                 295                 300                 


Met Met Gly Gln Glu Lys Val Pro Ile Lys Gln Val Pro Gly Gly Val 
305                 310                 315                 320 


Lys Gln Leu Glu Pro Pro Lys Glu Gly Glu Arg Arg Thr Thr His Asn 
                325                 330                 335     


Ile Ile Glu Lys Arg Tyr Arg Ser Ser Ile Asn Asp Lys Ile Ile Glu 
            340                 345                 350         


Leu Lys Asp Leu Val Met Gly Thr Asp Ala Lys Met His Lys Ser Gly 
        355                 360                 365             


Val Leu Arg Lys Ala Ile Asp Tyr Ile Lys Tyr Leu Gln Gln Val Asn 
    370                 375                 380                 


His Lys Leu Arg Gln Glu Asn Met Val Leu Lys Leu Ala Asn Gln Lys 
385                 390                 395                 400 


Asn Lys Leu Leu Lys Gly Ile Asp Leu Gly Ser Leu Val Asp Asn Glu 
                405                 410                 415     


Val Asp Leu Lys Ile Glu Asp Phe Asn Gln Asn Val Leu Leu Met Ser 
            420                 425                 430         


Pro Pro Ala Ser Asp Ser Gly Ser Gln Ala Gly Phe Ser Pro Tyr Ser 
        435                 440                 445             


Ile Asp Ser Glu Pro Gly Ser Pro Leu Leu Asp Asp Ala Lys Val Lys 
    450                 455                 460                 


Asp Glu Pro Asp Ser Pro Pro Val Ala Leu Gly Met Val Asp Arg Ser 
465                 470                 475                 480 


Arg Ile Leu Leu Cys Val Leu Thr Phe Leu Cys Leu Ser Phe Asn Pro 
                485                 490                 495     


Leu Thr Ser Leu Leu Gln Trp Gly Gly Ala His Asp Ser Asp Gln His 
            500                 505                 510         


Pro His Ser Gly Ser Gly Arg Ser Val Leu Ser Phe Glu Ser Gly Ser 
        515                 520                 525             


Gly Gly Trp Phe Asp Trp Met Met Pro Thr Leu Leu Leu Trp Leu Val 
    530                 535                 540                 


Asn Gly Val Ile Val Leu Ser Val Phe Val Lys Leu Leu Val His Gly 
545                 550                 555                 560 


Glu Pro Val Ile Arg Pro His Ser Arg Ser Ser Val Thr Phe Trp Arg 
                565                 570                 575     


His Arg Lys Gln Ala Asp Leu Asp Leu Ala Arg Gly Asp Phe Ala Ala 
            580                 585                 590         


Ala Ala Ala Asn Leu Gln Thr Cys Leu Ala Val Leu Gly Arg Ala Leu 
        595                 600                 605             


Pro Thr Ser Arg Leu Asp Leu Ala Cys Ser Leu Ser Trp Asn Val Ile 
    610                 615                 620                 


Arg Tyr Ser Leu Gln Lys Leu Arg Leu Val Arg Trp Leu Leu Lys Lys 
625                 630                 635                 640 


Val Phe Gln Cys Arg Arg Ala Thr Pro Ala Thr Glu Ala Gly Phe Glu 
                645                 650                 655     


Asp Glu Ala Lys Thr Ser Ala Arg Asp Ala Ala Leu Ala Tyr His Arg 
            660                 665                 670         


Leu His Gln Leu His Ile Thr Gly Lys Leu Pro Ala Gly Ser Ala Cys 
        675                 680                 685             


Ser Asp Val His Met Ala Leu Cys Ala Val Asn Leu Ala Glu Cys Ala 
    690                 695                 700                 


Glu Glu Lys Ile Pro Pro Ser Thr Leu Val Glu Ile His Leu Thr Ala 
705                 710                 715                 720 


Ala Met Gly Leu Lys Thr Arg Cys Gly Gly Lys Leu Gly Phe Leu Ala 
                725                 730                 735     


Ser Tyr Phe Leu Ser Arg Ala Gln Ser Leu Cys Gly Pro Glu His Ser 
            740                 745                 750         


Ala Val Pro Asp Ser Leu Arg Trp Leu Cys His Pro Leu Gly Gln Lys 
        755                 760                 765             


Phe Phe Met Glu Arg Ser Trp Ser Val Lys Ser Ala Ala Lys Glu Ser 
    770                 775                 780                 


Leu Tyr Cys Ala Gln Arg Asn Pro Ala Asp Pro Ile Ala Gln Val His 
785                 790                 795                 800 


Gln Ala Phe Cys Lys Asn Leu Leu Glu Arg Ala Ile Glu Ser Leu Val 
                805                 810                 815     


Lys Pro Gln Ala Lys Lys Lys Ala Gly Asp Gln Glu Glu Glu Ser Cys 
            820                 825                 830         


Glu Phe Ser Ser Ala Leu Glu Tyr Leu Lys Leu Leu His Ser Phe Val 
        835                 840                 845             


Asp Ser Val Gly Val Met Ser Pro Pro Leu Ser Arg Ser Ser Val Leu 
    850                 855                 860                 


Lys Ser Ala Leu Gly Pro Asp Ile Ile Cys Arg Trp Trp Thr Ser Ala 
865                 870                 875                 880 


Ile Thr Val Ala Ile Ser Trp Leu Gln Gly Asp Asp Ala Ala Val Arg 
                885                 890                 895     


Ser His Phe Thr Lys Val Glu Arg Ile Pro Lys Ala Leu Glu Val Thr 
            900                 905                 910         


Glu Ser Pro Leu Val Lys Ala Ile Phe His Ala Cys Arg Ala Met His 
        915                 920                 925             


Ala Ser Leu Pro Gly Lys Ala Asp Gly Gln Gln Ser Ser Phe Cys His 
    930                 935                 940                 


Cys Glu Arg Ala Ser Gly His Leu Trp Ser Ser Leu Asn Val Ser Gly 
945                 950                 955                 960 


Gly Thr Ser Asp Pro Ala Leu Asn His Val Val Gln Leu Leu Thr Cys 
                965                 970                 975     


Asp Leu Leu Leu Ser Leu Arg Thr Ala Leu Trp Gln Lys Gln Ala Ser 
            980                 985                 990         


Ala Ser Gln Ala Val Gly Glu Thr  Tyr His Ala Ser Gly  Ala Glu Leu 
        995                 1000                 1005             


Ala Gly  Phe Gln Arg Asp Leu  Gly Ser Leu Arg Arg  Leu Ala His 
    1010                 1015                 1020             


Ser Phe  Arg Pro Ala Tyr Arg  Lys Val Phe Leu His  Glu Ala Thr 
    1025                 1030                 1035             


Val Arg  Leu Met Ala Gly Gly  Ser Pro Thr Arg Thr  His Gln Leu 
    1040                 1045                 1050             


Leu Glu  His Ser Leu Arg Arg  Arg Thr Thr Gln Ser  Thr Lys His 
    1055                 1060                 1065             


Gly Glu  Val Asp Ala Trp Pro  Gly Gln Arg Glu Arg  Ala Thr Ala 
    1070                 1075                 1080             


Ile Leu  Leu Ala Cys Arg His  Leu Pro Leu Ser Phe  Leu Ser Ser 
    1085                 1090                 1095             


Pro Gly  Gln Arg Ala Val Leu  Leu Ala Glu Ala Ala  Arg Thr Leu 
    1100                 1105                 1110             


Glu Lys  Val Gly Asp Arg Arg  Ser Cys Asn Asp Cys  Gln Gln Met 
    1115                 1120                 1125             


Ile Val  Lys Leu Gly Gly Gly  Thr Ala Ile Ala Ala  Ser 
    1130                 1135                 1140     


<210>  26
<211>  167
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<223>  Human Leptin

<400>  26

Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                  15      


Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                  25                  30          


Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                  40                  45              


Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                  55                  60                  


Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                  70                  75                  80  


Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                  90                  95      


Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                 105                 110         


Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                 120                 125             


Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                 135                 140                 


Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                 150                 155                 160 


Leu Asp Leu Ser Pro Gly Cys 
                165         


<210>  27
<211>  141
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Wherein "Xaa" represents Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Wherein "Xaa" represents Gln, Glu, or absent

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Wherein "Xaa" represents Ile, Leu, Met or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (129)..(129)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (131)..(131)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (134)..(134)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  27

Val Xaa Asp Asp Thr Lys Thr Leu Ile Lys Thr Ile Val Thr Arg Ile 
1               5                   10                  15      


Xaa Asp Ile Ser His Xaa Xaa Ser Val Ser Ser Lys Xaa Lys Val Thr 
            20                  25                  30          


Gly Leu Asp Phe Ile Pro Gly Leu His Pro Ile Leu Thr Leu Ser Lys 
        35                  40                  45              


Xaa Asp Xaa Thr Leu Ala Val Tyr Xaa Xaa Ile Leu Thr Ser Xaa Pro 
    50                  55                  60                  


Ser Arg Xaa Val Ile Xaa Ile Ser Xaa Asp Leu Glu Xaa Leu Arg Asp 
65                  70                  75                  80  


Leu Leu His Val Leu Ala Phe Ser Lys Ser Cys His Leu Pro Xaa Ala 
                85                  90                  95      


Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly Gly Val Leu Glu Ala Ser 
            100                 105                 110         


Gly Tyr Ser Thr Glu Val Val Ala Leu Ser Arg Leu Xaa Gly Ser Leu 
        115                 120                 125             


Xaa Asp Xaa Leu Xaa Xaa Leu Asp Leu Ser Pro Gly Cys 
    130                 135                 140     


<210>  28
<211>  135
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Wherein "Xaa" represents Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Wherein "Xaa" represents Gln, Glu or absence of an amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methione sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methione sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (127)..(127)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (128)..(128)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  28

Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Xaa Asp Ile Ser His Xaa 
1               5                   10                  15      


Xaa Ser Val Ser Ser Lys Xaa Lys Val Thr Gly Leu Asp Phe Ile Pro 
            20                  25                  30          


Gly Leu His Pro Ile Leu Thr Leu Ser Lys Xaa Asp Xaa Thr Leu Ala 
        35                  40                  45              


Val Tyr Xaa Xaa Ile Leu Thr Ser Xaa Pro Ser Arg Xaa Val Ile Xaa 
    50                  55                  60                  


Ile Ser Xaa Asp Leu Glu Xaa Leu Arg Asp Leu Leu His Val Leu Ala 
65                  70                  75                  80  


Phe Ser Lys Ser Cys His Leu Pro Xaa Ala Ser Gly Leu Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
            100                 105                 110         


Val Ala Leu Ser Arg Leu Xaa Gly Ser Leu Xaa Asp Xaa Leu Xaa Xaa 
        115                 120                 125             


Leu Asp Leu Ser Pro Gly Cys 
    130                 135 


<210>  29
<211>  131
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Wherein "Xaa" represents Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Wherein "Xaa" represents Gln, Glu, or absence of an amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Wherein "Xaa" represents Ile, Leu, Met or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Wherein "Xaa" represents Asn, Asp, Gln

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (121)..(121)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (124)..(124)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  29

Thr Ile Val Thr Arg Ile Xaa Asp Ile Ser His Xaa Xaa Ser Val Ser 
1               5                   10                  15      


Ser Lys Xaa Lys Val Thr Gly Leu Asp Phe Ile Pro Gly Leu His Pro 
            20                  25                  30          


Ile Leu Thr Leu Ser Lys Xaa Asp Xaa Thr Leu Ala Val Tyr Xaa Xaa 
        35                  40                  45              


Ile Leu Thr Ser Xaa Pro Ser Arg Xaa Val Ile Xaa Ile Ser Xaa Asp 
    50                  55                  60                  


Leu Glu Xaa Leu Arg Asp Leu Leu His Val Leu Ala Phe Ser Lys Ser 
65                  70                  75                  80  


Cys His Leu Pro Xaa Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly 
                85                  90                  95      


Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val Ala Leu Ser 
            100                 105                 110         


Arg Leu Xaa Gly Ser Leu Xaa Asp Xaa Leu Xaa Xaa Leu Asp Leu Ser 
        115                 120                 125             


Pro Gly Cys 
    130     


<210>  30
<211>  126
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Wherein "Xaa" represents Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein "Xaa" represents Gln, Glu, or absence of an amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (118)..(118)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  30

Ile Xaa Asp Ile Ser His Xaa Xaa Ser Val Ser Ser Lys Xaa Lys Val 
1               5                   10                  15      


Thr Gly Leu Asp Phe Ile Pro Gly Leu His Pro Ile Leu Thr Leu Ser 
            20                  25                  30          


Lys Xaa Asp Xaa Thr Leu Ala Val Tyr Xaa Xaa Ile Leu Thr Ser Xaa 
        35                  40                  45              


Pro Ser Arg Xaa Val Ile Xaa Ile Ser Xaa Asp Leu Glu Xaa Leu Arg 
    50                  55                  60                  


Asp Leu Leu His Val Leu Ala Phe Ser Lys Ser Cys His Leu Pro Xaa 
65                  70                  75                  80  


Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly Gly Val Leu Glu Ala 
                85                  90                  95      


Ser Gly Tyr Ser Thr Glu Val Val Ala Leu Ser Arg Leu Xaa Gly Ser 
            100                 105                 110         


Leu Xaa Asp Xaa Leu Xaa Xaa Leu Asp Leu Ser Pro Gly Cys 
        115                 120                 125     


<210>  31
<211>  113
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  31

Xaa Lys Val Thr Gly Leu Asp Phe Ile Pro Gly Leu His Pro Ile Leu 
1               5                   10                  15      


Thr Leu Ser Lys Xaa Asp Xaa Thr Leu Ala Val Tyr Xaa Xaa Ile Leu 
            20                  25                  30          


Thr Ser Xaa Pro Ser Arg Xaa Val Ile Xaa Ile Ser Xaa Asp Leu Glu 
        35                  40                  45              


Xaa Leu Arg Asp Leu Leu His Val Leu Ala Phe Ser Lys Ser Cys His 
    50                  55                  60                  


Leu Pro Xaa Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly Gly Val 
65                  70                  75                  80  


Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val Ala Leu Ser Arg Leu 
                85                  90                  95      


Xaa Gly Ser Leu Xaa Asp Xaa Leu Xaa Xaa Leu Asp Leu Ser Pro Gly 
            100                 105                 110         


Cys 
    


<210>  32
<211>  105
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Wherein "Xaa" represents Ile, Leu, Met or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (95)..(95)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  32

Ile Pro Gly Leu His Pro Ile Leu Thr Leu Ser Lys Xaa Asp Xaa Thr 
1               5                   10                  15      


Leu Ala Val Tyr Xaa Xaa Ile Leu Thr Ser Xaa Pro Ser Arg Xaa Val 
            20                  25                  30          


Ile Xaa Ile Ser Xaa Asp Leu Glu Xaa Leu Arg Asp Leu Leu His Val 
        35                  40                  45              


Leu Ala Phe Ser Lys Ser Cys His Leu Pro Xaa Ala Ser Gly Leu Glu 
    50                  55                  60                  


Thr Leu Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr 
65                  70                  75                  80  


Glu Val Val Ala Leu Ser Arg Leu Xaa Gly Ser Leu Xaa Asp Xaa Leu 
                85                  90                  95      


Xaa Xaa Leu Asp Leu Ser Pro Gly Cys 
            100                 105 


<210>  33
<211>  93
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sufloxide

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  33

Xaa Asp Xaa Thr Leu Ala Val Tyr Xaa Xaa Ile Leu Thr Ser Xaa Pro 
1               5                   10                  15      


Ser Arg Xaa Val Ile Xaa Ile Ser Xaa Asp Leu Glu Xaa Leu Arg Asp 
            20                  25                  30          


Leu Leu His Val Leu Ala Phe Ser Lys Ser Cys His Leu Pro Xaa Ala 
        35                  40                  45              


Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly Gly Val Leu Glu Ala Ser 
    50                  55                  60                  


Gly Tyr Ser Thr Glu Val Val Ala Leu Ser Arg Leu Xaa Gly Ser Leu 
65                  70                  75                  80  


Xaa Asp Xaa Leu Xaa Xaa Leu Asp Leu Ser Pro Gly Cys 
                85                  90              


<210>  34
<211>  93
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Wherein "Xaa" represents Ile, Leu, Met or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  34

Xaa Asp Xaa Thr Leu Ala Val Tyr Xaa Xaa Ile Leu Thr Ser Xaa Pro 
1               5                   10                  15      


Ser Arg Xaa Val Ile Xaa Ile Ser Xaa Asp Leu Glu Xaa Leu Arg Asp 
            20                  25                  30          


Leu Leu His Val Leu Ala Phe Ser Lys Ser Cys His Leu Pro Xaa Ala 
        35                  40                  45              


Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly Gly Val Leu Glu Ala Ser 
    50                  55                  60                  


Gly Tyr Ser Thr Glu Val Val Ala Leu Ser Arg Leu Xaa Gly Ser Leu 
65                  70                  75                  80  


Xaa Asp Xaa Leu Xaa Xaa Leu Asp Leu Ser Pro Gly Cys 
                85                  90              


<210>  35
<211>  75
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methione sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  35

Xaa Val Ile Xaa Ile Ser Xaa Asp Leu Glu Xaa Leu Arg Asp Leu Leu 
1               5                   10                  15      


His Val Leu Ala Phe Ser Lys Ser Cys His Leu Pro Xaa Ala Ser Gly 
            20                  25                  30          


Leu Glu Thr Leu Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr 
        35                  40                  45              


Ser Thr Glu Val Val Ala Leu Ser Arg Leu Xaa Gly Ser Leu Xaa Asp 
    50                  55                  60                  


Xaa Leu Xaa Xaa Leu Asp Leu Ser Pro Gly Cys 
65                  70                  75  


<210>  36
<211>  62
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Wherein "Xaa' represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Wherein "Xaa' represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Wherein "Xaa' represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Wherein "Xaa' represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Wherein "Xaa' represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Wherein "Xaa' represents Gln or Glu

<400>  36

Asp Leu Leu His Val Leu Ala Phe Ser Lys Ser Cys His Leu Pro Xaa 
1               5                   10                  15      


Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly Gly Val Leu Glu Ala 
            20                  25                  30          


Ser Gly Tyr Ser Thr Glu Val Val Ala Leu Ser Arg Leu Xaa Gly Ser 
        35                  40                  45              


Leu Xaa Asp Xaa Leu Xaa Xaa Leu Asp Leu Ser Pro Gly Cys 
    50                  55                  60          


<210>  37
<211>  54
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  37

Ser Lys Ser Cys His Leu Pro Xaa Ala Ser Gly Leu Glu Thr Leu Asp 
1               5                   10                  15      


Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val 
            20                  25                  30          


Ala Leu Ser Arg Leu Xaa Gly Ser Leu Xaa Asp Xaa Leu Xaa Xaa Leu 
        35                  40                  45              


Asp Leu Ser Pro Gly Cys 
    50                  


<210>  38
<211>  74
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  38

Val Ile Xaa Ile Ser Xaa Asp Leu Glu Xaa Leu Arg Asp Leu Leu His 
1               5                   10                  15      


Val Leu Ala Phe Ser Lys Ser Cys His Leu Pro Xaa Ala Ser Gly Leu 
            20                  25                  30          


Glu Thr Leu Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser 
        35                  40                  45              


Thr Glu Val Val Ala Leu Ser Arg Leu Xaa Gly Ser Leu Xaa Asp Xaa 
    50                  55                  60                  


Leu Xaa Xaa Leu Asp Leu Ser Pro Gly Cys 
65                  70                  


<210>  39
<211>  63
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  39

Arg Asp Leu Leu His Val Leu Ala Phe Ser Lys Ser Cys His Leu Pro 
1               5                   10                  15      


Xaa Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly Gly Val Leu Glu 
            20                  25                  30          


Ala Ser Gly Tyr Ser Thr Glu Val Val Ala Leu Ser Arg Leu Xaa Gly 
        35                  40                  45              


Ser Leu Xaa Asp Xaa Leu Xaa Xaa Leu Asp Leu Ser Pro Gly Cys 
    50                  55                  60              


<210>  40
<211>  52
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Wherein "Xaa" represents Ile, Leu, Met, or methionine sulforxide

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Wherein "Xaa" represents Trp or Gln

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  40

Ser Cys His Leu Pro Xaa Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu 
1               5                   10                  15      


Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val Ala Leu 
            20                  25                  30          


Ser Arg Leu Xaa Gly Ser Leu Xaa Asp Xaa Leu Xaa Xaa Leu Asp Leu 
        35                  40                  45              


Ser Pro Gly Cys 
    50          


<210>  41
<211>  138
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Wherein "Xaa" represents Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Wherein "Xaa" represents Gln, Glu, or absence of an amino acid 
       residue

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Wherein "Xaa" represents Met, methionine sufloxide, Leu, Ile, 
       Val, Ala, or Gly

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Wherein "Xaa" represents Met, methione sufloxide, Leu, Ile, Val, 
       Ala, or Gly

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Wherein "Xaa" represents Asn, Asp, or Gln

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Wherein "Xaa" represents Gln, Trp, Tyr, Phe, Ile, Val, or Leu

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (134)..(134)
<223>  Wherein "Xaa" represents Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  Wherein "Xaa" represents Met, methionine sulfoxide, Leu, Ile, 
       Val, Ala, or Gly

<220>
<221>  MISC_FEATURE
<222>  (138)..(138)
<223>  Wherein "Xaa" represents Trp or Gln

<400>  41

Val Pro Ile Xaa Lys Val Xaa Asp Asp Thr Lys Thr Leu Ile Lys Thr 
1               5                   10                  15      


Ile Val Thr Arg Ile Xaa Asp Ile Ser His Xaa Xaa Ser Val Ser Ser 
            20                  25                  30          


Lys Xaa Lys Val Thr Gly Leu Asp Phe Ile Pro Gly Leu His Pro Ile 
        35                  40                  45              


Leu Thr Leu Ser Lys Xaa Asp Xaa Thr Leu Ala Val Tyr Xaa Xaa Ile 
    50                  55                  60                  


Leu Thr Ser Xaa Pro Ser Arg Xaa Val Ile Xaa Ile Ser Xaa Asp Leu 
65                  70                  75                  80  


Glu Xaa Leu Arg Asp Leu Leu His Val Leu Ala Phe Ser Lys Ser Cys 
                85                  90                  95      


His Leu Pro Xaa Ala Ser Gly Leu Glu Thr Leu Asp Ser Leu Gly Gly 
            100                 105                 110         


Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val Val Ala Leu Ser Arg 
        115                 120                 125             


Leu Xaa Gly Ser Leu Xaa Asp Xaa Leu Xaa 
    130                 135             


<210>  42
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Mammalian


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein "Xaa" represents Gln or Glu

<400>  42

Xaa Leu Asp Leu Ser Pro Gly Cys 
1               5               


<210>  43
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  43

Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys Thr Leu Ile Lys Thr
1               5                   10                  15

Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr Gln Ser Val Ser Ser 
            20                  25                  30

Lys Gln Lys
        35


<210>  44
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  44

Tyr Lys Val Gln Asp Asp Thr Lys Thr Leu Ile Lys Thr Ile Val
1               5                   10                  15


<210>  45
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  45

Asn Val Ile Gln Ile Ser Asn Asp Leu Glu Asn Leu Arg
1               5                   10            
