                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION

<120> MODIFIED MULLERIAN INHIBITING SUBSTANCE (MIS) PROTEINS AND USES
      THEREOF FOR THE TREATMENT OF DISEASES

<130> 030258-076964-PCT

<140>
<141>

<150> 61/777,135
<151> 2013-03-12

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 560
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Asp Leu Pro Leu Thr Ser Leu Ala Leu Val Leu Ser Ala Leu 
1               5                   10                  15      


Gly Ala Leu Leu Gly Thr Glu Ala Leu Arg Ala Glu Glu Pro Ala Val 
            20                  25                  30          


Gly Thr Ser Gly Leu Ile Phe Arg Glu Asp Leu Asp Trp Pro Pro Gly 
        35                  40                  45              


Ser Pro Gln Glu Pro Leu Cys Leu Val Ala Leu Gly Gly Asp Ser Asn 
    50                  55                  60                  


Gly Ser Ser Ser Pro Leu Arg Val Val Gly Ala Leu Ser Ala Tyr Glu 
65                  70                  75                  80  


Gln Ala Phe Leu Gly Ala Val Gln Arg Ala Arg Trp Gly Pro Arg Asp 
                85                  90                  95      


Leu Ala Thr Phe Gly Val Cys Asn Thr Gly Asp Arg Gln Ala Ala Leu 
            100                 105                 110         


Pro Ser Leu Arg Arg Leu Gly Ala Trp Leu Arg Asp Pro Gly Gly Gln 
        115                 120                 125             


Arg Leu Val Val Leu His Leu Glu Glu Val Thr Trp Glu Pro Thr Pro 
    130                 135                 140                 


Ser Leu Arg Phe Gln Glu Pro Pro Pro Gly Gly Ala Gly Pro Pro Glu 
145                 150                 155                 160 


Leu Ala Leu Leu Val Leu Tyr Pro Gly Pro Gly Pro Glu Val Thr Val 
                165                 170                 175     


Thr Arg Ala Gly Leu Pro Gly Ala Gln Ser Leu Cys Pro Ser Arg Asp 
            180                 185                 190         


Thr Arg Tyr Leu Val Leu Ala Val Asp Arg Pro Ala Gly Ala Trp Arg 
        195                 200                 205             


Gly Ser Gly Leu Ala Leu Thr Leu Gln Pro Arg Gly Glu Asp Ser Arg 
    210                 215                 220                 


Leu Ser Thr Ala Arg Leu Gln Ala Leu Leu Phe Gly Asp Asp His Arg 
225                 230                 235                 240 


Cys Phe Thr Arg Met Thr Pro Ala Leu Leu Leu Leu Pro Arg Ser Glu 
                245                 250                 255     


Pro Ala Pro Leu Pro Ala His Gly Gln Leu Asp Thr Val Pro Phe Pro 
            260                 265                 270         


Pro Pro Arg Pro Ser Ala Glu Leu Glu Glu Ser Pro Pro Ser Ala Asp 
        275                 280                 285             


Pro Phe Leu Glu Thr Leu Thr Arg Leu Val Arg Ala Leu Arg Val Pro 
    290                 295                 300                 


Pro Ala Arg Ala Ser Ala Pro Arg Leu Ala Leu Asp Pro Asp Ala Leu 
305                 310                 315                 320 


Ala Gly Phe Pro Gln Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Leu 
                325                 330                 335     


Glu Arg Leu Leu Asp Gly Glu Glu Pro Leu Leu Leu Leu Leu Arg Pro 
            340                 345                 350         


Thr Ala Ala Thr Thr Gly Asp Pro Ala Pro Leu His Asp Pro Thr Ser 
        355                 360                 365             


Ala Pro Trp Ala Thr Ala Leu Ala Arg Arg Val Ala Ala Glu Leu Gln 
    370                 375                 380                 


Ala Ala Ala Ala Glu Leu Arg Ser Leu Pro Gly Leu Pro Pro Ala Thr 
385                 390                 395                 400 


Ala Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Gly Pro Gly 
                405                 410                 415     


Gly Leu Gly Asp Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln 
            420                 425                 430         


Gly Leu Arg Val Glu Trp Arg Gly Arg Asp Pro Arg Gly Pro Gly Arg 
        435                 440                 445             


Ala Gln Arg Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu 
    450                 455                 460                 


Arg Glu Leu Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro 
465                 470                 475                 480 


Glu Thr Tyr Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln 
                485                 490                 495     


Ser Asp Arg Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys 
            500                 505                 510         


Met Gln Val Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro 
        515                 520                 525             


Thr Ala Tyr Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile 
    530                 535                 540                 


Ser Ala His His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
545                 550                 555                 560 


<210> 2
<211> 559
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Arg Ala Glu Glu Pro Ala Val Gly 
            20                  25                  30          


Thr Ser Gly Leu Ile Phe Arg Glu Asp Leu Asp Trp Pro Pro Gly Ser 
        35                  40                  45              


Pro Gln Glu Pro Leu Cys Leu Val Ala Leu Gly Gly Asp Ser Asn Gly 
    50                  55                  60                  


Ser Ser Ser Pro Leu Arg Val Val Gly Ala Leu Ser Ala Tyr Glu Gln 
65                  70                  75                  80  


Ala Phe Leu Gly Ala Val Gln Arg Ala Arg Trp Gly Pro Arg Asp Leu 
                85                  90                  95      


Ala Thr Phe Gly Val Cys Asn Thr Gly Asp Arg Gln Ala Ala Leu Pro 
            100                 105                 110         


Ser Leu Arg Arg Leu Gly Ala Trp Leu Arg Asp Pro Gly Gly Gln Arg 
        115                 120                 125             


Leu Val Val Leu His Leu Glu Glu Val Thr Trp Glu Pro Thr Pro Ser 
    130                 135                 140                 


Leu Arg Phe Gln Glu Pro Pro Pro Gly Gly Ala Gly Pro Pro Glu Leu 
145                 150                 155                 160 


Ala Leu Leu Val Leu Tyr Pro Gly Pro Gly Pro Glu Val Thr Val Thr 
                165                 170                 175     


Arg Ala Gly Leu Pro Gly Ala Gln Ser Leu Cys Pro Ser Arg Asp Thr 
            180                 185                 190         


Arg Tyr Leu Val Leu Ala Val Asp Arg Pro Ala Gly Ala Trp Arg Gly 
        195                 200                 205             


Ser Gly Leu Ala Leu Thr Leu Gln Pro Arg Gly Glu Asp Ser Arg Leu 
    210                 215                 220                 


Ser Thr Ala Arg Leu Gln Ala Leu Leu Phe Gly Asp Asp His Arg Cys 
225                 230                 235                 240 


Phe Thr Arg Met Thr Pro Ala Leu Leu Leu Leu Pro Arg Ser Glu Pro 
                245                 250                 255     


Ala Pro Leu Pro Ala His Gly Gln Leu Asp Thr Val Pro Phe Pro Pro 
            260                 265                 270         


Pro Arg Pro Ser Ala Glu Leu Glu Glu Ser Pro Pro Ser Ala Asp Pro 
        275                 280                 285             


Phe Leu Glu Thr Leu Thr Arg Leu Val Arg Ala Leu Arg Val Pro Pro 
    290                 295                 300                 


Ala Arg Ala Ser Ala Pro Arg Leu Ala Leu Asp Pro Asp Ala Leu Ala 
305                 310                 315                 320 


Gly Phe Pro Gln Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Leu Glu 
                325                 330                 335     


Arg Leu Leu Asp Gly Glu Glu Pro Leu Leu Leu Leu Leu Arg Pro Thr 
            340                 345                 350         


Ala Ala Thr Thr Gly Asp Pro Ala Pro Leu His Asp Pro Thr Ser Ala 
        355                 360                 365             


Pro Trp Ala Thr Ala Leu Ala Arg Arg Val Ala Ala Glu Leu Gln Ala 
    370                 375                 380                 


Ala Ala Ala Glu Leu Arg Ser Leu Pro Gly Leu Pro Pro Ala Thr Ala 
385                 390                 395                 400 


Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Gly Pro Gly Gly 
                405                 410                 415     


Leu Gly Asp Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly 
            420                 425                 430         


Leu Arg Val Glu Trp Arg Gly Arg Asp Pro Arg Gly Pro Gly Arg Ala 
        435                 440                 445             


Arg Arg Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu Arg 
    450                 455                 460                 


Glu Leu Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu 
465                 470                 475                 480 


Thr Tyr Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln Ser 
                485                 490                 495     


Asp Arg Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met 
            500                 505                 510         


Gln Val Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr 
        515                 520                 525             


Ala Tyr Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser 
    530                 535                 540                 


Ala His His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
545                 550                 555                 


<210> 3
<211> 567
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Arg Ala Glu Glu Pro Ala Val Gly 
            20                  25                  30          


Thr Ser Gly Leu Ile Phe Arg Glu Asp Leu Asp Trp Pro Pro Gly Ser 
        35                  40                  45              


Pro Gln Glu Pro Leu Cys Leu Val Ala Leu Gly Gly Asp Ser Asn Gly 
    50                  55                  60                  


Ser Ser Ser Pro Leu Arg Val Val Gly Ala Leu Ser Ala Tyr Glu Gln 
65                  70                  75                  80  


Ala Phe Leu Gly Ala Val Gln Arg Ala Arg Trp Gly Pro Arg Asp Leu 
                85                  90                  95      


Ala Thr Phe Gly Val Cys Asn Thr Gly Asp Arg Gln Ala Ala Leu Pro 
            100                 105                 110         


Ser Leu Arg Arg Leu Gly Ala Trp Leu Arg Asp Pro Gly Gly Gln Arg 
        115                 120                 125             


Leu Val Val Leu His Leu Glu Glu Val Thr Trp Glu Pro Thr Pro Ser 
    130                 135                 140                 


Leu Arg Phe Gln Glu Pro Pro Pro Gly Gly Ala Gly Pro Pro Glu Leu 
145                 150                 155                 160 


Ala Leu Leu Val Leu Tyr Pro Gly Pro Gly Pro Glu Val Thr Val Thr 
                165                 170                 175     


Arg Ala Gly Leu Pro Gly Ala Gln Ser Leu Cys Pro Ser Arg Asp Thr 
            180                 185                 190         


Arg Tyr Leu Val Leu Ala Val Asp Arg Pro Ala Gly Ala Trp Arg Gly 
        195                 200                 205             


Ser Gly Leu Ala Leu Thr Leu Gln Pro Arg Gly Glu Asp Ser Arg Leu 
    210                 215                 220                 


Ser Thr Ala Arg Leu Gln Ala Leu Leu Phe Gly Asp Asp His Arg Cys 
225                 230                 235                 240 


Phe Thr Arg Met Thr Pro Ala Leu Leu Leu Leu Pro Arg Ser Glu Pro 
                245                 250                 255     


Ala Pro Leu Pro Ala His Gly Gln Leu Asp Thr Val Pro Phe Pro Pro 
            260                 265                 270         


Pro Arg Pro Ser Ala Glu Leu Glu Glu Ser Pro Pro Ser Ala Asp Pro 
        275                 280                 285             


Phe Leu Glu Thr Leu Thr Arg Leu Val Arg Ala Leu Arg Val Pro Pro 
    290                 295                 300                 


Ala Arg Ala Ser Ala Pro Arg Leu Ala Leu Asp Pro Asp Ala Leu Ala 
305                 310                 315                 320 


Gly Phe Pro Gln Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Leu Glu 
                325                 330                 335     


Arg Leu Leu Asp Gly Glu Glu Pro Leu Leu Leu Leu Leu Arg Pro Thr 
            340                 345                 350         


Ala Ala Thr Thr Gly Asp Pro Ala Pro Leu His Asp Pro Thr Ser Ala 
        355                 360                 365             


Pro Trp Ala Thr Ala Leu Ala Arg Arg Val Ala Ala Glu Leu Gln Ala 
    370                 375                 380                 


Ala Ala Ala Glu Leu Arg Ser Leu Pro Gly Leu Pro Pro Ala Thr Ala 
385                 390                 395                 400 


Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Gly Pro Gly Gly 
                405                 410                 415     


Leu Gly Asp Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly 
            420                 425                 430         


Leu Arg Val Glu Trp Arg Gly Arg Asp Pro Arg Gly Pro Gly Arg Ala 
        435                 440                 445             


Arg Arg Ser Asp Tyr Lys Asp Asp Asp Asp Lys Ala Gly Ala Thr Ala 
    450                 455                 460                 


Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu Ser Val Asp Leu Arg Ala 
465                 470                 475                 480 


Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr Gln Ala Asn Asn Cys Gln 
                485                 490                 495     


Gly Val Cys Gly Trp Pro Gln Ser Asp Arg Asn Pro Arg Tyr Gly Asn 
            500                 505                 510         


His Val Val Leu Leu Leu Lys Met Gln Val Arg Gly Ala Ala Leu Ala 
        515                 520                 525             


Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr Ala Gly Lys Leu Leu Ile 
    530                 535                 540                 


Ser Leu Ser Glu Glu Arg Ile Ser Ala His His Val Pro Asn Met Val 
545                 550                 555                 560 


Ala Thr Glu Cys Gly Cys Arg 
                565         


<210> 4
<211> 1680
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atgaagtggg tgagcttcat cagcctgctg ttcctgttca gcagcgctta ctcccgcggt       60

gtgttccgcc gcagagcaga ggagccagct gtgggcacca gtggcctcat cttccgagaa      120

gacttggact ggcctccagg cagcccacaa gagcctctgt gcctggtggc actgggcggg      180

gacagcaatg gcagcagctc ccccctgcgg gtggtggggg ctctaagcgc ctatgagcag      240

gccttcctgg gggccgtgca gagggcccgc tggggccccc gagacctggc caccttcggg      300

gtctgcaaca ccggtgacag gcaggctgcc ttgccctctc tacggcggct gggggcctgg      360

ctgcgggacc ctggggggca gcgcctggtg gtcctacacc tggaggaagt gacctgggag      420

ccaacaccct cgctgaggtt ccaggagccc ccgcctggag gagctggccc cccagagctg      480

gcgctgctgg tgctgtaccc tgggcctggc cctgaggtca ctgtgacgag ggctgggctg      540

ccgggtgccc agagcctctg cccctcccga gacacccgct acctggtgtt agcggtggac      600

cgccctgcgg gggcctggcg cggctccggg ctggccttga ccctgcagcc ccgcggagag      660

gactcccggc tgagtaccgc ccggctgcag gcactgctgt tcggcgacga ccaccgctgc      720

ttcacacgga tgaccccggc cctgctcctg ctgccgcggt ccgagcccgc gccgctgcct      780

gcgcacggcc agctggacac cgtgcccttc ccgccgccca ggccatccgc ggaactcgag      840

gagtcgccac ccagcgcaga ccccttcctg gagacgctca cgcgcctggt gcgggcgctg      900

cgggtccccc cggcccgggc ctccgcgccg cgcctggccc tggatccgga cgcgctggcc      960

ggcttcccgc agggcctagt caacctgtcg gaccccgcgg cgctggagcg cctactcgac     1020

ggcgaggagc cgctgctgct gctgctgagg cccactgcgg ccaccaccgg ggatcctgcg     1080

cccctgcacg accccacgtc ggcgccgtgg gccacggccc tggcgcgccg cgtggctgct     1140

gaactgcaag cggcggctgc cgagctgcga agcctcccgg gtctgcctcc ggccacagcc     1200

ccgctgctgg cgcgcctgct cgcgctctgc ccaggtggcc ccggcggcct cggcgatccc     1260

ctgcgagcgc tgctgctcct gaaggcgctg cagggcctgc gcgtggagtg gcgcgggcgg     1320

gatccgcgcg ggccgggtcg ggcacggcgc agcgcggggg ccaccgccgc cgacgggccg     1380

tgcgcgctgc gcgagctcag cgtagacctc cgcgccgagc gctccgtact catccccgag     1440

acctaccagg ccaacaattg ccagggcgtg tgcggctggc ctcagtccga ccgcaacccg     1500

cgctacggca accacgtggt gctgctgctg aagatgcagg cccgtggggc cgccctggcg     1560

cgcccaccct gctgcgtgcc caccgcctac gcgggcaagc tgctcatcag cctgtcggag     1620

gagcgcatca gcgcgcacca cgtgcccaac atggtggcca ccgagtgtgg ctgccggtga     1680


<210> 5
<211> 1704
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atgaagtggg tgagcttcat cagcctgctg ttcctgttca gcagcgctta ctcccgcggt       60

gtgttccgcc gcagagcaga ggagccagct gtgggcacca gtggcctcat cttccgagaa      120

gacttggact ggcctccagg cagcccacaa gagcctctgt gcctggtggc actgggcggg      180

gacagcaatg gcagcagctc ccccctgcgg gtggtggggg ctctaagcgc ctatgagcag      240

gccttcctgg gggccgtgca gagggcccgc tggggccccc gagacctggc caccttcggg      300

gtctgcaaca ccggtgacag gcaggctgcc ttgccctctc tacggcggct gggggcctgg      360

ctgcgggacc ctggggggca gcgcctggtg gtcctacacc tggaggaagt gacctgggag      420

ccaacaccct cgctgaggtt ccaggagccc ccgcctggag gagctggccc cccagagctg      480

gcgctgctgg tgctgtaccc tgggcctggc cctgaggtca ctgtgacgag ggctgggctg      540

ccgggtgccc agagcctctg cccctcccga gacacccgct acctggtgtt agcggtggac      600

cgccctgcgg gggcctggcg cggctccggg ctggccttga ccctgcagcc ccgcggagag      660

gactcccggc tgagtaccgc ccggctgcag gcactgctgt tcggcgacga ccaccgctgc      720

ttcacacgga tgaccccggc cctgctcctg ctgccgcggt ccgagcccgc gccgctgcct      780

gcgcacggcc agctggacac cgtgcccttc ccgccgccca ggccatccgc ggaactcgag      840

gagtcgccac ccagcgcaga ccccttcctg gagacgctca cgcgcctggt gcgggcgctg      900

cgggtccccc cggcccgggc ctccgcgccg cgcctggccc tggatccgga cgcgctggcc      960

ggcttcccgc agggcctagt caacctgtcg gaccccgcgg cgctggagcg cctactcgac     1020

ggcgaggagc cgctgctgct gctgctgagg cccactgcgg ccaccaccgg ggatcctgcg     1080

cccctgcacg accccacgtc ggcgccgtgg gccacggccc tggcgcgccg cgtggctgct     1140

gaactgcaag cggcggctgc cgagctgcga agcctcccgg gtctgcctcc ggccacagcc     1200

ccgctgctgg cgcgcctgct cgcgctctgc ccaggtggcc ccggcggcct cggcgatccc     1260

ctgcgagcgc tgctgctcct gaaggcgctg cagggcctgc gcgtggagtg gcgcgggcgg     1320

gatccgcgcg ggccgggtcg ggcacggcgc agcgactaca aggatgacga cgacaaggcg     1380

ggggccaccg ccgccgacgg gccgtgcgcg ctgcgcgagc tcagcgtaga cctccgcgcc     1440

gagcgctccg tactcatccc cgagacctac caggccaaca attgccaggg cgtgtgcggc     1500

tggcctcagt ccgaccgcaa cccgcgctac ggcaaccacg tggtgctgct gctgaagatg     1560

caggcccgtg gggccgccct ggcgcgccca ccctgctgcg tgcccaccgc ctacgcgggc     1620

aagctgctca tcagcctgtc ggaggagcgc atcagcgcgc accacgtgcc caacatggtg     1680

gccaccgagt gtggctgccg gtga                                            1704


<210> 6
<211> 24
<212> PRT
<213> Homo sapiens

<400> 6
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg 
            20                  


<210> 7
<211> 78
<212> DNA
<213> Homo sapiens

<400> 7
atgaagtggg tgagcttcat cagcctgctg ttcctgttca gcagcgctta ctcccgcggt       60

gtgttccgcc gcagagca                                                     78


<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 9
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
gactacaagg atgacgacga caag                                              24


<210> 10
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Leu Glu Leu Val Pro Arg Gly Ser Gly Asp Pro Ile Glu Gly Arg Gly 
1               5                   10                  15      


Gly Gly Gly Gly Asp Pro Lys Ser Cys Asp Lys Pro His Thr Cys Pro 
            20                  25                  30          


Leu Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Ala Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210> 11
<211> 101
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
cgagatacat gaagtgggtg agcttcatca gcctgctgtt cctgttcagc agcgcttact       60

cccgcggtgt gttccggcgc agagcagagg agccagctgt g                          101


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
gctcctggaa cctcagcgag                                                   20


<210> 13
<211> 18
<212> PRT
<213> Homo sapiens

<400> 13
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210> 14
<211> 18
<212> PRT
<213> Homo sapiens

<400> 14
Met Lys Trp Val Ser Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210> 15
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: MPIF-1 
      signal sequence

<400> 15
Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Thr Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala 
            20      


<210> 16
<211> 17
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Stanniocalcin 
      signal sequence

<400> 16
Met Leu Gln Asn Ser Ala Val Leu Leu Leu Leu Val Ile Ser Ala Ser 
1               5                   10                  15      


Ala 
    


<210> 17
<211> 19
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Invertase 
      signal sequence

<400> 17
Met Leu Leu Gln Ala Phe Leu Phe Leu Leu Ala Gly Phe Ala Ala Lys 
1               5                   10                  15      


Ile Ser Ala 
            


<210> 18
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Met Lys Trp Val Ser Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Ser Leu Glu Lys Arg 
            20                  


<210> 19
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Met Lys Trp Val Ser Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Ser Leu Asp Lys Arg 
            20                  


<210> 20
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Met Asn Ile Phe Tyr Ile Phe Leu Phe Leu Leu Ser Phe Val Gln Gly 
1               5                   10                  15      


Ser Leu Asp Lys Arg 
            20      


<210> 21
<211> 19
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Immunoglobulin 
      Ig signal sequence

<400> 21
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210> 22
<211> 29
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Fibulin B 
      precursor signal sequence

<400> 22
Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala 
            20                  25                  


<210> 23
<211> 22
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Clusterin 
      precursor signal sequence

<400> 23
Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly 
            20          


<210> 24
<211> 21
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Insulin-like 
      growth factor-binding protein 4 signal sequence

<400> 24
Met Leu Pro Leu Cys Leu Val Ala Ala Leu Leu Leu Ala Ala Gly Pro 
1               5                   10                  15      


Gly Pro Ser Leu Gly 
            20      


<210> 25
<211> 25
<212> PRT
<213> Homo sapiens

<400> 25
Met Arg Asp Leu Pro Leu Thr Ser Leu Ala Leu Val Leu Ser Ala Leu 
1               5                   10                  15      


Gly Ala Leu Leu Gly Thr Glu Ala Leu 
            20                  25  


<210> 26
<211> 5
<212> PRT
<213> Homo sapiens

<400> 26
Arg Ala Gln Arg Ser 
1               5   


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Arg Ala Arg Arg Ser 
1               5   


<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Arg Ala Gln Arg Arg 
1               5   


