                         SEQUENCE LISTING

<110>  Wacker Chemie AG
 
<120>  Mikroorganismenstamm und Verfahren zur fermentativen Herstellung 
       von C4-Verbindungen aus C5-Zuckern

<130>  Tkt/Tal

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  2109
<212>  DNA
<213>  Raoultella terrigena


<220>
<221>  CDS
<222>  (1)..(2109)
<223>  Transketolase

<400>  1
atg tac atg ttt tgt cgc ttg ggt tac att gtt gtc act ttt ttc cgg         48
Met Tyr Met Phe Cys Arg Leu Gly Tyr Ile Val Val Thr Phe Phe Arg           
1               5                   10                  15                

cgt agc cca aaa cgc gct gtc gtc aag tcg tta agg gta tgg cct tca         96
Arg Ser Pro Lys Arg Ala Val Val Lys Ser Leu Arg Val Trp Pro Ser           
            20                  25                  30                    

aca gtc cga act gga gtc aaa atg tcc tca cgt aaa gag ctt gct aac        144
Thr Val Arg Thr Gly Val Lys Met Ser Ser Arg Lys Glu Leu Ala Asn           
        35                  40                  45                        

gct att cgt gcg ctg agc atg gac gcg gta cag aaa gcc aaa tcc ggc        192
Ala Ile Arg Ala Leu Ser Met Asp Ala Val Gln Lys Ala Lys Ser Gly           
    50                  55                  60                            

cac ccg ggt gcc ccg atg ggt atg gct gac att gcc gaa gtc ctg tgg        240
His Pro Gly Ala Pro Met Gly Met Ala Asp Ile Ala Glu Val Leu Trp           
65                  70                  75                  80            

cgt gat ttc ctg aat cat aac ccg aac aac ccg gcc tgg gcc gat cgc        288
Arg Asp Phe Leu Asn His Asn Pro Asn Asn Pro Ala Trp Ala Asp Arg           
                85                  90                  95                

gac cgt ttc gtg ctc tcc aac ggc cac ggc tca atg ctg att tac agc        336
Asp Arg Phe Val Leu Ser Asn Gly His Gly Ser Met Leu Ile Tyr Ser           
            100                 105                 110                   

ctg ctg cat ctc acc ggt tat gat ctg ccg att gaa gaa ctg aaa aac        384
Leu Leu His Leu Thr Gly Tyr Asp Leu Pro Ile Glu Glu Leu Lys Asn           
        115                 120                 125                       

ttc cgt cag ctg cac tcc aga acc ccg ggc cac ccg gaa gtt ggc tac        432
Phe Arg Gln Leu His Ser Arg Thr Pro Gly His Pro Glu Val Gly Tyr           
    130                 135                 140                           

acc gcc ggc gtt gaa acc acc acc ggc ccg ctg ggc cag ggg att gcc        480
Thr Ala Gly Val Glu Thr Thr Thr Gly Pro Leu Gly Gln Gly Ile Ala           
145                 150                 155                 160           

aac gcg gtc ggg atg gcg att gct gaa aaa acc ctg gcg gcg cag ttc        528
Asn Ala Val Gly Met Ala Ile Ala Glu Lys Thr Leu Ala Ala Gln Phe           
                165                 170                 175               

aac cgt ccg ggc cac gat atc gtt gac cac ttc acc tac gcc ttc atg        576
Asn Arg Pro Gly His Asp Ile Val Asp His Phe Thr Tyr Ala Phe Met           
            180                 185                 190                   

ggc gac ggc tgc atg atg gaa ggc att tct cac gaa gtg tgc tcc ctg        624
Gly Asp Gly Cys Met Met Glu Gly Ile Ser His Glu Val Cys Ser Leu           
        195                 200                 205                       

gcc ggt acc ctg aag ctg ggc aag ctg gtg gcg ttc tat gac gac aac        672
Ala Gly Thr Leu Lys Leu Gly Lys Leu Val Ala Phe Tyr Asp Asp Asn           
    210                 215                 220                           

ggc atc tcc atc gac ggt cac gtt gaa ggc tgg ttc acc gac gat acc        720
Gly Ile Ser Ile Asp Gly His Val Glu Gly Trp Phe Thr Asp Asp Thr           
225                 230                 235                 240           

gct aaa cgt ttc gaa gcc tac ggc tgg cac gtg gtg cgc ggc gtt gac        768
Ala Lys Arg Phe Glu Ala Tyr Gly Trp His Val Val Arg Gly Val Asp           
                245                 250                 255               

ggc cat gac gct gag gcc atc aaa cgc gcg gta gaa gaa gcg cgt gcg        816
Gly His Asp Ala Glu Ala Ile Lys Arg Ala Val Glu Glu Ala Arg Ala           
            260                 265                 270                   

gtg acc gac aag ccg tcc ctg ctg atg tgc aaa acc atc atc ggc ttc        864
Val Thr Asp Lys Pro Ser Leu Leu Met Cys Lys Thr Ile Ile Gly Phe           
        275                 280                 285                       

ggt tcg ccg aac aaa cag ggc acc cac gac tcc cac ggc gcg ccg ctg        912
Gly Ser Pro Asn Lys Gln Gly Thr His Asp Ser His Gly Ala Pro Leu           
    290                 295                 300                           

ggc gac gcg gaa atc gcg ctg acc cgc gag gcc ctg ggc tgg acc cac        960
Gly Asp Ala Glu Ile Ala Leu Thr Arg Glu Ala Leu Gly Trp Thr His           
305                 310                 315                 320           

ccg gcg ttt gaa atc ccg tct gac atc tac gcg cag tgg gat gcg aaa       1008
Pro Ala Phe Glu Ile Pro Ser Asp Ile Tyr Ala Gln Trp Asp Ala Lys           
                325                 330                 335               

gaa gcc ggt cag gct aaa gaa gca gcg tgg aac gag aag ttc gct gct       1056
Glu Ala Gly Gln Ala Lys Glu Ala Ala Trp Asn Glu Lys Phe Ala Ala           
            340                 345                 350                   

tat gcg aaa gcc ttc ccg cag gaa gcc gcc gag tat acc cgc cgc atg       1104
Tyr Ala Lys Ala Phe Pro Gln Glu Ala Ala Glu Tyr Thr Arg Arg Met           
        355                 360                 365                       

aag ggt gaa atg ccg gct gac ttc gac gcg aaa gcg aac gaa ttc atc       1152
Lys Gly Glu Met Pro Ala Asp Phe Asp Ala Lys Ala Asn Glu Phe Ile           
    370                 375                 380                           

gcg aaa ctg cag gct aac ccg gcg aaa atc gcc agc cgt aaa gcg tcg       1200
Ala Lys Leu Gln Ala Asn Pro Ala Lys Ile Ala Ser Arg Lys Ala Ser           
385                 390                 395                 400           

cag aat gcg att gaa gcc ttt ggc ccg ctg ctg cct gaa ttc ctc ggc       1248
Gln Asn Ala Ile Glu Ala Phe Gly Pro Leu Leu Pro Glu Phe Leu Gly           
                405                 410                 415               

ggc tcg gct gac ctg gcg ccg tcc aac ctg acc atc tgg tcc ggc tcg       1296
Gly Ser Ala Asp Leu Ala Pro Ser Asn Leu Thr Ile Trp Ser Gly Ser           
            420                 425                 430                   

aag gcg att aac gaa gac acc gcc ggg aac tac atc cac tac ggc gtg       1344
Lys Ala Ile Asn Glu Asp Thr Ala Gly Asn Tyr Ile His Tyr Gly Val           
        435                 440                 445                       

cgt gag ttc ggg atg acc gcg att gcc aac ggt atc tcc ctg cac ggc       1392
Arg Glu Phe Gly Met Thr Ala Ile Ala Asn Gly Ile Ser Leu His Gly           
    450                 455                 460                           

ggt ttc ctg ccg tac acc tct acc ttc ctg atg ttc gtg gag tac gcg       1440
Gly Phe Leu Pro Tyr Thr Ser Thr Phe Leu Met Phe Val Glu Tyr Ala           
465                 470                 475                 480           

cgt aac gcg gta cgt atg gcg gcg ctg atg aag cag cgt cag gtg atg       1488
Arg Asn Ala Val Arg Met Ala Ala Leu Met Lys Gln Arg Gln Val Met           
                485                 490                 495               

gtc tac acc cac gac tcc atc ggt ctg ggc gaa gac ggc ccg acg cac       1536
Val Tyr Thr His Asp Ser Ile Gly Leu Gly Glu Asp Gly Pro Thr His           
            500                 505                 510                   

cag ccg gtc gag cag gtg gct tcc ctg cgc gtg acg ccg aac atg agc       1584
Gln Pro Val Glu Gln Val Ala Ser Leu Arg Val Thr Pro Asn Met Ser           
        515                 520                 525                       

aca tgg cgt ccg tgt gac cag gtg gaa tcg gcg att gcg tgg aaa tac       1632
Thr Trp Arg Pro Cys Asp Gln Val Glu Ser Ala Ile Ala Trp Lys Tyr           
    530                 535                 540                           

ggc gtt gag cgt cac gac ggc ccg acg gcg ctg atc ctg tca cgt cag       1680
Gly Val Glu Arg His Asp Gly Pro Thr Ala Leu Ile Leu Ser Arg Gln           
545                 550                 555                 560           

aac ctg gcg cag cag gag cgt acg gcg gag cag ctg gcg aac gtt gcc       1728
Asn Leu Ala Gln Gln Glu Arg Thr Ala Glu Gln Leu Ala Asn Val Ala           
                565                 570                 575               

cgc ggc ggc tac gtg ctg aag gat tgt gcc ggc cag ccg gag ctg atc       1776
Arg Gly Gly Tyr Val Leu Lys Asp Cys Ala Gly Gln Pro Glu Leu Ile           
            580                 585                 590                   

ttc att gcc acc ggt tca gaa gtt gag ctg gcg gtt gcc gcg tgg gac       1824
Phe Ile Ala Thr Gly Ser Glu Val Glu Leu Ala Val Ala Ala Trp Asp           
        595                 600                 605                       

cag ctg tct gca gaa ggg gtg aag gcg cgc gtg gtc tcc atg ccg tcc       1872
Gln Leu Ser Ala Glu Gly Val Lys Ala Arg Val Val Ser Met Pro Ser           
    610                 615                 620                           

acc gat gcc ttc gac aag cag gat gcg gcg tac cgt gaa tcg gtg ctg       1920
Thr Asp Ala Phe Asp Lys Gln Asp Ala Ala Tyr Arg Glu Ser Val Leu           
625                 630                 635                 640           

ccg aaa gcg gtt tcg gct cgc gtg gcc gtg gaa gcg ggt atc gct gac       1968
Pro Lys Ala Val Ser Ala Arg Val Ala Val Glu Ala Gly Ile Ala Asp           
                645                 650                 655               

tac tgg ttc aaa tac gtg ggt ctg aac ggc gcc atc gtc ggt atg acc       2016
Tyr Trp Phe Lys Tyr Val Gly Leu Asn Gly Ala Ile Val Gly Met Thr           
            660                 665                 670                   

agc ttc ggc gag tct gcg ccg gct gag ctg ctg ttc gaa gag ttc ggc       2064
Ser Phe Gly Glu Ser Ala Pro Ala Glu Leu Leu Phe Glu Glu Phe Gly           
        675                 680                 685                       

ttc acc gtt gag aac gtg gtc gct aag gcg aaa gcg ctg ctg tag           2109
Phe Thr Val Glu Asn Val Val Ala Lys Ala Lys Ala Leu Leu                   
    690                 695                 700                           


<210>  2
<211>  702
<212>  PRT
<213>  Raoultella terrigena

<400>  2

Met Tyr Met Phe Cys Arg Leu Gly Tyr Ile Val Val Thr Phe Phe Arg 
1               5                   10                  15      


Arg Ser Pro Lys Arg Ala Val Val Lys Ser Leu Arg Val Trp Pro Ser 
            20                  25                  30          


Thr Val Arg Thr Gly Val Lys Met Ser Ser Arg Lys Glu Leu Ala Asn 
        35                  40                  45              


Ala Ile Arg Ala Leu Ser Met Asp Ala Val Gln Lys Ala Lys Ser Gly 
    50                  55                  60                  


His Pro Gly Ala Pro Met Gly Met Ala Asp Ile Ala Glu Val Leu Trp 
65                  70                  75                  80  


Arg Asp Phe Leu Asn His Asn Pro Asn Asn Pro Ala Trp Ala Asp Arg 
                85                  90                  95      


Asp Arg Phe Val Leu Ser Asn Gly His Gly Ser Met Leu Ile Tyr Ser 
            100                 105                 110         


Leu Leu His Leu Thr Gly Tyr Asp Leu Pro Ile Glu Glu Leu Lys Asn 
        115                 120                 125             


Phe Arg Gln Leu His Ser Arg Thr Pro Gly His Pro Glu Val Gly Tyr 
    130                 135                 140                 


Thr Ala Gly Val Glu Thr Thr Thr Gly Pro Leu Gly Gln Gly Ile Ala 
145                 150                 155                 160 


Asn Ala Val Gly Met Ala Ile Ala Glu Lys Thr Leu Ala Ala Gln Phe 
                165                 170                 175     


Asn Arg Pro Gly His Asp Ile Val Asp His Phe Thr Tyr Ala Phe Met 
            180                 185                 190         


Gly Asp Gly Cys Met Met Glu Gly Ile Ser His Glu Val Cys Ser Leu 
        195                 200                 205             


Ala Gly Thr Leu Lys Leu Gly Lys Leu Val Ala Phe Tyr Asp Asp Asn 
    210                 215                 220                 


Gly Ile Ser Ile Asp Gly His Val Glu Gly Trp Phe Thr Asp Asp Thr 
225                 230                 235                 240 


Ala Lys Arg Phe Glu Ala Tyr Gly Trp His Val Val Arg Gly Val Asp 
                245                 250                 255     


Gly His Asp Ala Glu Ala Ile Lys Arg Ala Val Glu Glu Ala Arg Ala 
            260                 265                 270         


Val Thr Asp Lys Pro Ser Leu Leu Met Cys Lys Thr Ile Ile Gly Phe 
        275                 280                 285             


Gly Ser Pro Asn Lys Gln Gly Thr His Asp Ser His Gly Ala Pro Leu 
    290                 295                 300                 


Gly Asp Ala Glu Ile Ala Leu Thr Arg Glu Ala Leu Gly Trp Thr His 
305                 310                 315                 320 


Pro Ala Phe Glu Ile Pro Ser Asp Ile Tyr Ala Gln Trp Asp Ala Lys 
                325                 330                 335     


Glu Ala Gly Gln Ala Lys Glu Ala Ala Trp Asn Glu Lys Phe Ala Ala 
            340                 345                 350         


Tyr Ala Lys Ala Phe Pro Gln Glu Ala Ala Glu Tyr Thr Arg Arg Met 
        355                 360                 365             


Lys Gly Glu Met Pro Ala Asp Phe Asp Ala Lys Ala Asn Glu Phe Ile 
    370                 375                 380                 


Ala Lys Leu Gln Ala Asn Pro Ala Lys Ile Ala Ser Arg Lys Ala Ser 
385                 390                 395                 400 


Gln Asn Ala Ile Glu Ala Phe Gly Pro Leu Leu Pro Glu Phe Leu Gly 
                405                 410                 415     


Gly Ser Ala Asp Leu Ala Pro Ser Asn Leu Thr Ile Trp Ser Gly Ser 
            420                 425                 430         


Lys Ala Ile Asn Glu Asp Thr Ala Gly Asn Tyr Ile His Tyr Gly Val 
        435                 440                 445             


Arg Glu Phe Gly Met Thr Ala Ile Ala Asn Gly Ile Ser Leu His Gly 
    450                 455                 460                 


Gly Phe Leu Pro Tyr Thr Ser Thr Phe Leu Met Phe Val Glu Tyr Ala 
465                 470                 475                 480 


Arg Asn Ala Val Arg Met Ala Ala Leu Met Lys Gln Arg Gln Val Met 
                485                 490                 495     


Val Tyr Thr His Asp Ser Ile Gly Leu Gly Glu Asp Gly Pro Thr His 
            500                 505                 510         


Gln Pro Val Glu Gln Val Ala Ser Leu Arg Val Thr Pro Asn Met Ser 
        515                 520                 525             


Thr Trp Arg Pro Cys Asp Gln Val Glu Ser Ala Ile Ala Trp Lys Tyr 
    530                 535                 540                 


Gly Val Glu Arg His Asp Gly Pro Thr Ala Leu Ile Leu Ser Arg Gln 
545                 550                 555                 560 


Asn Leu Ala Gln Gln Glu Arg Thr Ala Glu Gln Leu Ala Asn Val Ala 
                565                 570                 575     


Arg Gly Gly Tyr Val Leu Lys Asp Cys Ala Gly Gln Pro Glu Leu Ile 
            580                 585                 590         


Phe Ile Ala Thr Gly Ser Glu Val Glu Leu Ala Val Ala Ala Trp Asp 
        595                 600                 605             


Gln Leu Ser Ala Glu Gly Val Lys Ala Arg Val Val Ser Met Pro Ser 
    610                 615                 620                 


Thr Asp Ala Phe Asp Lys Gln Asp Ala Ala Tyr Arg Glu Ser Val Leu 
625                 630                 635                 640 


Pro Lys Ala Val Ser Ala Arg Val Ala Val Glu Ala Gly Ile Ala Asp 
                645                 650                 655     


Tyr Trp Phe Lys Tyr Val Gly Leu Asn Gly Ala Ile Val Gly Met Thr 
            660                 665                 670         


Ser Phe Gly Glu Ser Ala Pro Ala Glu Leu Leu Phe Glu Glu Phe Gly 
        675                 680                 685             


Phe Thr Val Glu Asn Val Val Ala Lys Ala Lys Ala Leu Leu 
    690                 695                 700         


<210>  3
<211>  954
<212>  DNA
<213>  Raoultella terrigena


<220>
<221>  CDS
<222>  (1)..(954)
<223>  Transaldolase

<400>  3
atg acg gat aaa ttg act tct ctg cgt cag tac acc act gtc gta gct         48
Met Thr Asp Lys Leu Thr Ser Leu Arg Gln Tyr Thr Thr Val Val Ala           
1               5                   10                  15                

gat acc gga gat att gcg gca atg aag ctg tat cag cct cag gac gcc         96
Asp Thr Gly Asp Ile Ala Ala Met Lys Leu Tyr Gln Pro Gln Asp Ala           
            20                  25                  30                    

acg act aac cct tct ttg att ctt ggc gct gct cag atc cct gag tac        144
Thr Thr Asn Pro Ser Leu Ile Leu Gly Ala Ala Gln Ile Pro Glu Tyr           
        35                  40                  45                        

cgt aag ctg att gat gac gct atc gtc tgg gcc cgc gct cag agc agc        192
Arg Lys Leu Ile Asp Asp Ala Ile Val Trp Ala Arg Ala Gln Ser Ser           
    50                  55                  60                            

gat cgc gcg cag cag gtt atc gac gct tcc gat aag ctg gcg gtg aac        240
Asp Arg Ala Gln Gln Val Ile Asp Ala Ser Asp Lys Leu Ala Val Asn           
65                  70                  75                  80            

att ggt ctc gaa atc ctt aag ctg att cca ggc cgt att tct acc gaa        288
Ile Gly Leu Glu Ile Leu Lys Leu Ile Pro Gly Arg Ile Ser Thr Glu           
                85                  90                  95                

gtt gat gcc cgt ctc tcc tat gac acc acg gca tcc atc gct aaa gct        336
Val Asp Ala Arg Leu Ser Tyr Asp Thr Thr Ala Ser Ile Ala Lys Ala           
            100                 105                 110                   

aaa cgc atc atc aag ctg tac aac gat gcg ggc atc ggc aac gat cgc        384
Lys Arg Ile Ile Lys Leu Tyr Asn Asp Ala Gly Ile Gly Asn Asp Arg           
        115                 120                 125                       

att ctg atc aaa ctg gct tct acc tgg cag ggc atc tgc gcc gcc gag        432
Ile Leu Ile Lys Leu Ala Ser Thr Trp Gln Gly Ile Cys Ala Ala Glu           
    130                 135                 140                           

cag ctg gaa aaa gaa ggc atc aac tgt aac ctg acc ctg ctg ttc tcc        480
Gln Leu Glu Lys Glu Gly Ile Asn Cys Asn Leu Thr Leu Leu Phe Ser           
145                 150                 155                 160           

ttc gct cag gct cgc gcc tgt gcg gaa gcg ggc gta ttc ctg att tcg        528
Phe Ala Gln Ala Arg Ala Cys Ala Glu Ala Gly Val Phe Leu Ile Ser           
                165                 170                 175               

ccg ttc gta ggc cgt atc ctc gac tgg tac aaa gcg aac acg gat aag        576
Pro Phe Val Gly Arg Ile Leu Asp Trp Tyr Lys Ala Asn Thr Asp Lys           
            180                 185                 190                   

aaa gag tat gcg ccg gcg gaa gat ccg ggc gtg gtt tcc gtc agc gaa        624
Lys Glu Tyr Ala Pro Ala Glu Asp Pro Gly Val Val Ser Val Ser Glu           
        195                 200                 205                       

atc tac gaa tac tac aag cag cac ggc tat gaa acc gtc gta atg ggc        672
Ile Tyr Glu Tyr Tyr Lys Gln His Gly Tyr Glu Thr Val Val Met Gly           
    210                 215                 220                           

gca agc ttc cgt aac gtc ggc gaa atc ctc gag ctg gcc ggc tgt gac        720
Ala Ser Phe Arg Asn Val Gly Glu Ile Leu Glu Leu Ala Gly Cys Asp           
225                 230                 235                 240           

cgt ctg acc atc gct ccg gca ctg ctg aaa gag ctg gca gaa agc gaa        768
Arg Leu Thr Ile Ala Pro Ala Leu Leu Lys Glu Leu Ala Glu Ser Glu           
                245                 250                 255               

ggc gct atc gaa cgt aag ctg acc ttc agc ggc gaa gtg aaa gcc cgt        816
Gly Ala Ile Glu Arg Lys Leu Thr Phe Ser Gly Glu Val Lys Ala Arg           
            260                 265                 270                   

ccg gaa cgc atc acc gaa tct cag ttc ctg tgg cag cac aac cag gat        864
Pro Glu Arg Ile Thr Glu Ser Gln Phe Leu Trp Gln His Asn Gln Asp           
        275                 280                 285                       

ccg atg gcg gta gat aaa ctg gcg gaa ggt atc cgt aag ttt gct atc        912
Pro Met Ala Val Asp Lys Leu Ala Glu Gly Ile Arg Lys Phe Ala Ile           
    290                 295                 300                           

gac cag gaa aaa ctg gaa aaa atg atc ggc gat ctg ctg taa                954
Asp Gln Glu Lys Leu Glu Lys Met Ile Gly Asp Leu Leu                       
305                 310                 315                               


<210>  4
<211>  317
<212>  PRT
<213>  Raoultella terrigena

<400>  4

Met Thr Asp Lys Leu Thr Ser Leu Arg Gln Tyr Thr Thr Val Val Ala 
1               5                   10                  15      


Asp Thr Gly Asp Ile Ala Ala Met Lys Leu Tyr Gln Pro Gln Asp Ala 
            20                  25                  30          


Thr Thr Asn Pro Ser Leu Ile Leu Gly Ala Ala Gln Ile Pro Glu Tyr 
        35                  40                  45              


Arg Lys Leu Ile Asp Asp Ala Ile Val Trp Ala Arg Ala Gln Ser Ser 
    50                  55                  60                  


Asp Arg Ala Gln Gln Val Ile Asp Ala Ser Asp Lys Leu Ala Val Asn 
65                  70                  75                  80  


Ile Gly Leu Glu Ile Leu Lys Leu Ile Pro Gly Arg Ile Ser Thr Glu 
                85                  90                  95      


Val Asp Ala Arg Leu Ser Tyr Asp Thr Thr Ala Ser Ile Ala Lys Ala 
            100                 105                 110         


Lys Arg Ile Ile Lys Leu Tyr Asn Asp Ala Gly Ile Gly Asn Asp Arg 
        115                 120                 125             


Ile Leu Ile Lys Leu Ala Ser Thr Trp Gln Gly Ile Cys Ala Ala Glu 
    130                 135                 140                 


Gln Leu Glu Lys Glu Gly Ile Asn Cys Asn Leu Thr Leu Leu Phe Ser 
145                 150                 155                 160 


Phe Ala Gln Ala Arg Ala Cys Ala Glu Ala Gly Val Phe Leu Ile Ser 
                165                 170                 175     


Pro Phe Val Gly Arg Ile Leu Asp Trp Tyr Lys Ala Asn Thr Asp Lys 
            180                 185                 190         


Lys Glu Tyr Ala Pro Ala Glu Asp Pro Gly Val Val Ser Val Ser Glu 
        195                 200                 205             


Ile Tyr Glu Tyr Tyr Lys Gln His Gly Tyr Glu Thr Val Val Met Gly 
    210                 215                 220                 


Ala Ser Phe Arg Asn Val Gly Glu Ile Leu Glu Leu Ala Gly Cys Asp 
225                 230                 235                 240 


Arg Leu Thr Ile Ala Pro Ala Leu Leu Lys Glu Leu Ala Glu Ser Glu 
                245                 250                 255     


Gly Ala Ile Glu Arg Lys Leu Thr Phe Ser Gly Glu Val Lys Ala Arg 
            260                 265                 270         


Pro Glu Arg Ile Thr Glu Ser Gln Phe Leu Trp Gln His Asn Gln Asp 
        275                 280                 285             


Pro Met Ala Val Asp Lys Leu Ala Glu Gly Ile Arg Lys Phe Ala Ile 
    290                 295                 300                 


Asp Gln Glu Lys Leu Glu Lys Met Ile Gly Asp Leu Leu 
305                 310                 315         


<210>  5
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  5
atacaattga tgtacatgtt ttgtcgcttg ggtt                                   34


<210>  6
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR-Primer

<400>  6
tctaagctta ctacagcagc gctttcgcct tagc                                   34


<210>  7
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  7
atagaattca tgacggataa attgacttct c                                      31


<210>  8
<211>  32
<212>  DNA
<213>  Artificiial sequence

<400>  8
tctctgcagt tacagcagat cgccgatcat tt                                     32


<210>  9
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR Primer

<400>  9
tctcaattgc cctcctctgc agactacagc agcgctttcg ccttagc                     47


