                         SEQUENCE LISTING

<110>  Peter MacCallum Cancer Institute
       Macheda, Maria Luisa
       Halford, Michael Maurice
       Stacker, Steven
       Parish, Clare Louise
       Nice, Edouard Collins
 
<120>  ANTIBODIES AGAINST HUMAN RYK AND USES THEREFOR

<130>  951579

<140>  AU 2013901150
<141>  2013-04-03

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile His Lys Ala Gly His Thr Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Tyr Arg His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Val 
    210                 215                 220                 


Gly Ser Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
225                 230                 235                 240 


<210>  2
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile His Lys Ala Gly His Thr Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Tyr Arg His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Val Gly Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  4
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  4

Ser Tyr Ala Met Ser 
1               5   


<210>  5
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  5

Leu Ile His Lys Ala Gly His Thr Thr Gln Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly Val 
        


<210>  6
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Tyr Arg His Phe Asp 
1               5       


<210>  7
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  7

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  8

Arg Ala Ser Asn Leu Gln Ser Gly Val Pro Ser 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  9

Ala Val Gly Ser Pro Arg Thr 
1               5           


<210>  10
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  10

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Arg Val Gly Phe Pro Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Gly His Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Gln Ala Ser Val Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Gly 
    210                 215                 220                 


Pro Ala Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
225                 230                 235                 240 


<210>  11
<211>  134
<212>  PRT
<213>  Mus musculus

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Arg Val Gly Phe Pro Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Gly His Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Pro Gly Pro Ala Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg 
    130                 


<210>  12
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Gly Pro Ala Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  13
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  13

Ser Tyr Ala Met Ser 
1               5   


<210>  14
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  14

Thr Ile Ser Arg Val Gly Phe Pro Thr 
1               5                   


<210>  15
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  15

Arg Gly His Pro Phe Asp 
1               5       


<210>  16
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  16

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  17
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  17

Gln Ala Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
1               5                   10                  


<210>  18
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  18

Pro Gly Pro Ala Pro Pro Thr 
1               5           


<210>  19
<211>  446
<212>  PRT
<213>  Mus musculus

<400>  19

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile His Lys Ala Gly His Thr Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Tyr Arg His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  20
<211>  213
<212>  PRT
<213>  Mus musculus

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Val Gly Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Leu Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu 
    210             


<210>  21
<211>  720
<212>  DNA
<213>  Mus musculus

<400>  21
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcactg attcataagg ctggtcatac tacacagtac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttat      300

cgtcattttg actactgggg ccagggaacc ctggtcaccg tctcgagcgg tggaggcggt      360

tcaggcggag gtggcagcgg cggtggcggg tcgacggaca tccagatgac ccagtctcca      420

tcctccctgt ctgcatctgt aggagacaga gtcgccatca cttgccgggc aagtcagagc      480

attagcagct atttaaattg gtatcagcag aaaccaggga aagcccctaa gctcctgatc      540

tatcgggcat ccaatttgca aagtggggtc ccatcaaggt tcagtggcag tggatctggg      600

acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttactactgt      660

caacaggctg ttggttctcc tcgtacgttc ggccaaggga ccaaggtgga aatcaaacgg      720


<210>  22
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  22
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcactg attcataagg ctggtcatac tacacagtac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggttat      300

cgtcattttg actactgggg ccagggaacc ctggtcaccg tctcgagc                   348


<210>  23
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  23
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcgcc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatcgg gcatccaatt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag gctgttggtt ctcctcgtac gttcggccaa      300

gggaccaagg tggaaatcaa acgg                                             324


<210>  24
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  24
agctatgcca tgagc                                                        15


<210>  25
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  25
ctgattcata aggctggtca tactacacag tacgcagact ccgtgaaggg c                51


<210>  26
<211>  18
<212>  DNA
<213>  Mus musculus

<400>  26
ggttatcgtc attttgac                                                     18


<210>  27
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  27
cgggcaagtc agagcattag cagctattta aat                                    33


<210>  28
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  28
cgggcatcca atttgcaaag tggggtccca tca                                    33


<210>  29
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  29
gctgttggtt ctcctcgtac g                                                 21


<210>  30
<211>  720
<212>  DNA
<213>  Mus musculus

<400>  30
gaggtgcagc tgttggagtc tgggggaggc ttggtatagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacg atttcgcggg ttggttttcc gacagtttac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaacgtggt      300

catccgtttg actactgggg ccagggaacc ctggtcaccg tctcgagcgg tggaggcggt      360

tcaggcggag gtggcagcgg cggtggcggg tcgacggaca tccagatgac ccagtctcca      420

tcctccctgt ctgcatctgt aggagacaga gtcaccatca cttgccgggc aagtcagagc      480

attagcagct atttaaattg gtatcagcag aaaccaggga aagcccctaa gctcctgatc      540

tatcaggcat ccgttttgca aagtggggtc ccatcaaggt tcagtggcag tggatctggg      600

acagatttca ctctcaccat cagcagtctg caacctgaag attttgcaac ttactactgt      660

caacagccgg gtcctgctcc tccgacgttc ggccaaggga ccaaggtgga aatcaaacgg      720


<210>  31
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  31
gaggtgcagc tgttggagtc tgggggaggc ttggtatagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacg atttcgcggg ttggttttcc gacagtttac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaacgtggt      300

catccgtttg actactgggg ccagggaacc ctggtcaccg tctcgagc                   348


<210>  32
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  32
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatcag gcatccgttt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag ccgggtcctg ctcctccgac gttcggccaa      300

gggaccaagg tggaaatcaa acgg                                             324


<210>  33
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  33
agctatgcca tgagc                                                        15


<210>  34
<211>  60
<212>  DNA
<213>  Mus musculus

<400>  34
acgatttcgc gggttggttt tccgacagtt tacgcagact ccgtgaaggg ccggttcacc       60


<210>  35
<211>  18
<212>  DNA
<213>  Mus musculus

<400>  35
cgtggtcatc cgtttgac                                                     18


<210>  36
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  36
cgggcaagtc agagcattag cagctattta aat                                    33


<210>  37
<211>  42
<212>  DNA
<213>  Mus musculus

<400>  37
caggcatccg ttttgcaaag tggggtccca tcaaggttca gt                          42


<210>  38
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  38
ccgggtcctg ctcctccgac gttcggccaa                                        30


<210>  39
<211>  1395
<212>  DNA
<213>  Mus musculus

<400>  39
atggaactgg gcctgagctg gatcttcctg ctggccatcc tgaagggcgt gcagtgcgag       60

gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ctcactgatt cataaggctg gtcatactac acagtacgca      240

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa aggttatcgt      360

cattttgact actggggcca gggaaccctg gtcaccgtct ccagcgctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctccgg gtaaa                                                      1395


<210>  40
<211>  699
<212>  DNA
<213>  Mus musculus

<400>  40
atgcgcgtgc ctgcccagct gctgggcctg ctcctgctgt ggctgcccgg cacccggtgc       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcgcc      120

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      180

gggaaagccc ctaagctcct gatctatcgg gcatccaatt tgcaaagtgg ggtcccatca      240

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      300

gaagattttg caacttacta ctgtcaacag gctgttggtt ctcctcgtac cttcggccaa      360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgcttaa taacttctat      480

cccagggagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagcttgc ccgtcacaaa gagcttcaac aggggagag                             699


<210>  41
<211>  2942
<212>  DNA
<213>  Homo sapiens

<400>  41
cggctcgggg ctgtgagcgg ctcggggccg ggggtgggcg gcggtgcggc gggcggccga       60

cgctcctctt cggcggcggc ggcggcggcc atgcgtgggg cggcgcggct ggggcggccg      120

ggccggagtt gcctcccggg ggcccgcggc ctgagggccc cgccgccgcc gccgctgctg      180

cttctgcttg cgctgttgcc gctgctgccc gcgcctggcg ctgccgccgc ccccgccccg      240

cggcccccgg agctgcagtc ggcttccgcg gggcccagcg tgagtctcta cctgagcgag      300

gacgaggtgc gccggctgat cggtcttgat gcagaacttt attatgtgag aaatgacctt      360

attagtcact acgctctatc ctttagtctg ttagtaccca gtgagacaaa tttcctgcac      420

ttcacctggc atgcgaagtc caaggttgaa tataagctgg gattccaagt ggacaatgtt      480

ttggcaatgg atatgcccca ggtcaacatt tctgttcagg gggaagttcc acgcacttta      540

tcagtgtttc gggtagagct ttcctgtact ggcaaagtag attctgaagt tatgatacta      600

atgcagctca acttgacagt aaattcttca aaaaatttta ccgtcttaaa ttttaaacga      660

aggaaaatgt gctacaaaaa acttgaagaa gtaaaaactt cagccttgga caaaaacact      720

agcagaacta tttatgatcc tgtacatgca gctccaacca cttctacgcg tgtgttttat      780

attagtgtag gggtttgttg tgcagtaata tttctcgtag caataatatt agctgttttg      840

caccttcata gtatgaaaag gattgaactg gatgacagca ttagtgccag cagtagttcc      900

caagggctgt ctcagccatc cacccagacg actcagtatc tgagagcaga cacgcccaac      960

aatgcaactc ctatcaccag ctccttaggt tatcctacct tgcggataga gaagaacgac     1020

ttgagaagtg tcactctttt ggaggccaaa ggcaaggtga aggatatagc aatatccaga     1080

gagaggataa ctctaaaaga tgtactccaa gaaggtactt ttgggcgtat tttccatggg     1140

attttaatag atgaaaaaga tccaaataaa gaaaaacaag catttgtcaa aacagttaaa     1200

gatcaagctt ctgaaattca ggtgacaatg atgctcactg aaagttgtaa gctgcgaggt     1260

cttcatcaca gaaatcttct tcctattact catgtgtgta tagaagaagg agaaaagccc     1320

atggtgatat tgccttacat gaattggggg aatcttaaat tgtttttacg acagtgcaag     1380

ttagtagagg ccaataatcc acaggcaatt tctcagcaag acctggtaca catggctatt     1440

cagattgcct gtggaatgag ctacctggcc agaagggaag tcatccacaa agacctggct     1500

gccaggaact gtgtcattga tgacacactt caagttaaga tcacagacaa tgccctctcc     1560

agagacttgt tccccatgga ctatcactgt ctgggggaca atgaaaacag gccagttcgt     1620

tggatggctc ttgaaagtct ggttaataac gagttctcta gcgctagtga tgtgtgggcc     1680

tttggagtga cgctgtggga actcatgact ctgggccaga ctccctacgt ggacattgac     1740

cccttcgaga tggccgcata cctgaaagat ggttaccgaa tagcccagcc aatcaactgt     1800

cctgatgaat tatttgctgt gatggcctgt tgctgggcct tagatccaga ggagaggccc     1860

aagtttcagc agctggtaca gtgcctaaca gagtttcatg cagccctggg ggcctacgtc     1920

tgactcctct ccaatcccac accatcagga agaaggtgcc tgtcggggct cacttgaagc     1980

ctgtcaggga tgctttgtat ctaacacaac gccaacagaa gcacatttgt cttccagaac     2040

accgtgcctt agaaatgctt tagaatctga actttttaag acagacttaa taatgtggca     2100

tattttctag atatcacttt tattaggttg aactgaaagg gtttttgtaa attttttggc     2160

caaaattttt taaaacatac ttactttgga ctaggggtac attcttacaa aataaataaa     2220

cagtttttaa aattgtttag acacagatat ttggaattag ctatcttagt gccaactgct     2280

ttttattttt ttacttcatc aaggtgatgt aagtgactca cctttaaagt ttttttagtg     2340

ttatttttta tcactactct gggaaatggt ttgtcttcaa gatgcaatac ttttcttagt     2400

aaaggaaaaa cagcataaaa agatacctgg tctgccttgt acaagaaaag gcaatattag     2460

aggaagaaaa tttaaagaaa agctagagga aaaaaaaatt tttttaaaaa tacttattag     2520

aagcaaactg cccttgcatg gaaaactgtt tatttttttc agtgaaaagg aattctgctt     2580

tcgtgttttt gggaaagcag gaactgagtt cattacatct ttaatttggc agaaattagc     2640

ctttctgtga accagatgtg gtttggggca gatctgtagt aaacaatggt gattttattt     2700

atttttactc tctggaaaag gagataatac aattccagaa agtgaactca tatttctaag     2760

gttaagattc ccttttattg cacctagaat agtgctatgc acagagcggg tgcttgagtt     2820

gttgtcgttt tttgtttgtt ttttaaatgt aaactggtaa attttgtgct tatcttcaag     2880

gctggcttaa gtataaaatt gttttttaaa cacttgaaaa attaaaggat ttgttttata     2940

tt                                                                    2942


<210>  42
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Arg Gly Ala Ala Arg Leu Gly Arg Pro Gly Arg Ser Cys Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly Leu Arg Ala Pro Pro Pro Pro Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Leu Leu Pro Leu Leu Pro Ala Pro Gly Ala Ala Ala Ala Pro 
        35                  40                  45              


Ala Pro Arg Pro Pro Glu Leu Gln Ser Ala Ser Ala Gly Pro Ser Val 
    50                  55                  60                  


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Ile Gly Leu Asp 
65                  70                  75                  80  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
                85                  90                  95      


Ser Phe Ser Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
            100                 105                 110         


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
        115                 120                 125             


Asn Val Leu Ala Met Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly 
    130                 135                 140                 


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
145                 150                 155                 160 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
                165                 170                 175     


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
            180                 185                 190         


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
        195                 200                 205             


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
    210                 215                 220                 


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
225                 230                 235                 240 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
                245                 250                 255     


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
            260                 265                 270         


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
        275                 280                 285             


Pro Asn Asn Ala Thr Pro Ile Thr Ser Ser Leu Gly Tyr Pro Thr Leu 
    290                 295                 300                 


Arg Ile Glu Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys 
305                 310                 315                 320 


Gly Lys Val Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys 
                325                 330                 335     


Asp Val Leu Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu 
            340                 345                 350         


Ile Asp Glu Lys Asp Pro Asn Lys Glu Lys Gln Ala Phe Val Lys Thr 
        355                 360                 365             


Val Lys Asp Gln Ala Ser Glu Ile Gln Val Thr Met Met Leu Thr Glu 
    370                 375                 380                 


Ser Cys Lys Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr 
385                 390                 395                 400 


His Val Cys Ile Glu Glu Gly Glu Lys Pro Met Val Ile Leu Pro Tyr 
                405                 410                 415     


Met Asn Trp Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val 
            420                 425                 430         


Glu Ala Asn Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met 
        435                 440                 445             


Ala Ile Gln Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val 
    450                 455                 460                 


Ile His Lys Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu 
465                 470                 475                 480 


Gln Val Lys Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met 
                485                 490                 495     


Asp Tyr His Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met 
            500                 505                 510         


Ala Leu Glu Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val 
        515                 520                 525             


Trp Ala Phe Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr 
    530                 535                 540                 


Pro Tyr Val Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp 
545                 550                 555                 560 


Gly Tyr Arg Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala 
                565                 570                 575     


Val Met Ala Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe 
            580                 585                 590         


Gln Gln Leu Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala 
        595                 600                 605             


Tyr Val 
    610 


<210>  43
<211>  2936
<212>  DNA
<213>  Homo sapiens

<400>  43
cggctcgggg ctgtgagcgg ctcggggccg ggggtgggcg gcggtgcggc gggcggccga       60

cgctcctctt cggcggcggc ggcggcggcc atgcgtgggg cggcgcggct ggggcggccg      120

ggccggagtt gcctcccggg ggcccgcggc ctgagggccc cgccgccgcc gccgctgctg      180

cttctgcttg cgctgttgcc gctgctgccc gcgcctggcg ctgccgccgc ccccgccccg      240

cggcccccgg agctgcagtc ggcttccgcg gggcccagcg tgagtctcta cctgagcgag      300

gacgaggtgc gccggctgat cggtcttgat gcagaacttt attatgtgag aaatgacctt      360

attagtcact acgctctatc ctttagtctg ttagtaccca gtgagacaaa tttcctgcac      420

ttcacctggc atgcgaagtc caaggttgaa tataagctgg gattccaagt ggacaatgtt      480

ttggcaatgg atatgcccca ggtcaacatt tctgttcagg gggaagttcc acgcacttta      540

tcagtgtttc gggtagagct ttcctgtact ggcaaagtag attctgaagt tatgatacta      600

atgcagctca acttgacagt aaattcttca aaaaatttta ccgtcttaaa ttttaaacga      660

aggaaaatgt gctacaaaaa acttgaagaa gtaaaaactt cagccttgga caaaaacact      720

agcagaacta tttatgatcc tgtacatgca gctccaacca cttctacgcg tgtgttttat      780

attagtgtag gggtttgttg tgcagtaata tttctcgtag caataatatt agctgttttg      840

caccttcata gtatgaaaag gattgaactg gatgacagca ttagtgccag cagtagttcc      900

caagggctgt ctcagccatc cacccagacg actcagtatc tgagagcaga cacgcccaac      960

aatgcaactc ctatcaccag ttatcctacc ttgcggatag agaagaacga cttgagaagt     1020

gtcactcttt tggaggccaa aggcaaggtg aaggatatag caatatccag agagaggata     1080

actctaaaag atgtactcca agaaggtact tttgggcgta ttttccatgg gattttaata     1140

gatgaaaaag atccaaataa agaaaaacaa gcatttgtca aaacagttaa agatcaagct     1200

tctgaaattc aggtgacaat gatgctcact gaaagttgta agctgcgagg tcttcatcac     1260

agaaatcttc ttcctattac tcatgtgtgt atagaagaag gagaaaagcc catggtgata     1320

ttgccttaca tgaattgggg gaatcttaaa ttgtttttac gacagtgcaa gttagtagag     1380

gccaataatc cacaggcaat ttctcagcaa gacctggtac acatggctat tcagattgcc     1440

tgtggaatga gctacctggc cagaagggaa gtcatccaca aagacctggc tgccaggaac     1500

tgtgtcattg atgacacact tcaagttaag atcacagaca atgccctctc cagagacttg     1560

ttccccatgg actatcactg tctgggggac aatgaaaaca ggccagttcg ttggatggct     1620

cttgaaagtc tggttaataa cgagttctct agcgctagtg atgtgtgggc ctttggagtg     1680

acgctgtggg aactcatgac tctgggccag actccctacg tggacattga ccccttcgag     1740

atggccgcat acctgaaaga tggttaccga atagcccagc caatcaactg tcctgatgaa     1800

gctttatttg ctgtgatggc ctgttgctgg gccttagatc cagaggagag gcccaagttt     1860

cagcagctgg tacagtgcct aacagagttt catgcagccc tgggggccta cgtctgactc     1920

ctctccaatc ccacaccatc aggaagaagg tgcctgtcgg ggctcacttg aagcctgtca     1980

gggatgcttt gtatctaaca caacgccaac agaagcacat ttgtcttcca gaacaccgtg     2040

ccttagaaat gctttagaat ctgaactttt taagacagac ttaataatgt ggcatatttt     2100

ctagatatca cttttattag gttgaactga aagggttttt gtaaattttt tggccaaaat     2160

tttttaaaac atacttactt tggactaggg gtacattctt acaaaataaa taaacagttt     2220

ttaaaattgt ttagacacag atatttggaa ttagctatct tagtgccaac tgctttttat     2280

ttttttactt catcaaggtg atgtaagtga ctcaccttta aagttttttt agtgttattt     2340

tttatcacta ctctgggaaa tggtttgtct tcaagatgca atacttttct tagtaaagga     2400

aaaacagcat aaaaagatac ctggtctgcc ttgtacaaga aaaggcaata ttagaggaag     2460

aaaatttaaa gaaaagctag aggaaaaaaa aattttttta aaaatactta ttagaagcaa     2520

actgcccttg catggaaaac tgtttatttt tttcagtgaa aaggaattct gctttcgtgt     2580

ttttgggaaa gcaggaactg agttcattac atctttaatt tggcagaaat tagcctttct     2640

gtgaaccaga tgtggtttgg ggcagatctg tagtaaacaa tggtgatttt atttattttt     2700

actctctgga aaaggagata atacaattcc agaaagtgaa ctcatatttc taaggttaag     2760

attccctttt attgcaccta gaatagtgct atgcacagag cgggtgcttg agttgttgtc     2820

gttttttgtt tgttttttaa atgtaaactg gtaaattttg tgcttatctt caaggctggc     2880

ttaagtataa aattgttttt taaacacttg aaaaattaaa ggatttgttt tatatt         2936


<210>  44
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Arg Gly Ala Ala Arg Leu Gly Arg Pro Gly Arg Ser Cys Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly Leu Arg Ala Pro Pro Pro Pro Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Leu Leu Pro Leu Leu Pro Ala Pro Gly Ala Ala Ala Ala Pro 
        35                  40                  45              


Ala Pro Arg Pro Pro Glu Leu Gln Ser Ala Ser Ala Gly Pro Ser Val 
    50                  55                  60                  


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Ile Gly Leu Asp 
65                  70                  75                  80  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
                85                  90                  95      


Ser Phe Ser Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
            100                 105                 110         


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
        115                 120                 125             


Asn Val Leu Ala Met Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly 
    130                 135                 140                 


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
145                 150                 155                 160 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
                165                 170                 175     


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
            180                 185                 190         


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
        195                 200                 205             


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
    210                 215                 220                 


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
225                 230                 235                 240 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
                245                 250                 255     


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
            260                 265                 270         


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
        275                 280                 285             


Pro Asn Asn Ala Thr Pro Ile Thr Ser Tyr Pro Thr Leu Arg Ile Glu 
    290                 295                 300                 


Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys Gly Lys Val 
305                 310                 315                 320 


Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys Asp Val Leu 
                325                 330                 335     


Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu Ile Asp Glu 
            340                 345                 350         


Lys Asp Pro Asn Lys Glu Lys Gln Ala Phe Val Lys Thr Val Lys Asp 
        355                 360                 365             


Gln Ala Ser Glu Ile Gln Val Thr Met Met Leu Thr Glu Ser Cys Lys 
    370                 375                 380                 


Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr His Val Cys 
385                 390                 395                 400 


Ile Glu Glu Gly Glu Lys Pro Met Val Ile Leu Pro Tyr Met Asn Trp 
                405                 410                 415     


Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val Glu Ala Asn 
            420                 425                 430         


Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met Ala Ile Gln 
        435                 440                 445             


Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val Ile His Lys 
    450                 455                 460                 


Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu Gln Val Lys 
465                 470                 475                 480 


Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met Asp Tyr His 
                485                 490                 495     


Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met Ala Leu Glu 
            500                 505                 510         


Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val Trp Ala Phe 
        515                 520                 525             


Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr Pro Tyr Val 
    530                 535                 540                 


Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp Gly Tyr Arg 
545                 550                 555                 560 


Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala Val Met Ala 
                565                 570                 575     


Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe Gln Gln Leu 
            580                 585                 590         


Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala Tyr Val 
        595                 600                 605         


<210>  45
<211>  1398
<212>  DNA
<213>  Mus musculus

<400>  45
atggaactgg gcctgagctg gatcttcctg ctggccatcc tgaagggcgt gcagtgcgag       60

gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac ctttagcagc tatgccatga gctgggtccg ccaggctcca      180

gggaaggggc tggagtgggt ctcactgatt cataaggctg gtcatactac acagtacgca      240

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa aggttatcgt      360

cattttgact actggggcca gggaaccctg gtcaccgtct ccagcgctag caccaagggc      420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1380

ctgtctccgg gtaaatga                                                   1398


<210>  46
<211>  699
<212>  DNA
<213>  Mus musculus

<400>  46
atgcgcgtgc ctgcccagct gctgggcctg ctcctgctgt ggctgcccgg cacccggtgc       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcgcc      120

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      180

gggaaagccc ctaagctcct gatctatcgg gcatccaatt tgcaaagtgg ggtcccatca      240

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      300

gaagattttg caacttacta ctgtcaacag gctgttggtt ctcctcgtac cttcggccaa      360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgcttaa taacttctat      480

cccagggagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagcttgc ccgtcacaaa gagcttcaac aggggagag                             699


