                              SEQUENCE LISTING

<110> Infectious Disease Research Institute
      GUDERIAN, Jeff
      DUTHIE, Malcolm
      REED, Steven G.

<120> Vaccines Comprising Leishmania
  Polypeptides for the Treatment and Diagnosis of
  Leishmaniasis

<130> 712192002940

<140> PCT/US2014/032276   
<141> 2014-03-28  

<150> 61/806,368          
<151> 2013-03-28  

<150> 61/822,545          
<151> 2013-05-13  

<160> 45

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2868
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding NSC Fusion Polypeptide

<400> 1
atgccgcgca agattattct cgattgtgat cccgggatcg atgatgccgt ggccatcttt 60
ctcgcccacg gcaacccgga ggtcgagctg ctggccatta cgacggtggt gggcaaccag 120
accctggaga aggtgacccg gaacgcgcgg ctggtagctg acgtagccgg catcgttggt 180
gtgcccgtcg cggctggttg caccaagccc ctcgtgcgcg gtgtgcggaa tgcctctcag 240
attcatggcg aaaccggcat gggtaacgtc tcctacccac cagagttcaa gacaaagttg 300
gacggccgtc atgcagtgca gctgatcatc gaccttatca tgtcgcacga gccgaagacg 360
atcacgcttg tgcctacggg tggcctgacg aacattgcga tggctgtccg tcttgagccg 420
cgcatcgtgg accgtgtgaa ggaggtggtt ctgatgggtg gcggctacca tactggtaat 480
gcgtcccctg tagcggagtt caacgtcttc gtcgacccgg aggcggcgca cattgtgttc 540
aacgagagct ggaacgtaac gatggtgggg ctggacctaa cgcaccaggc actcgccacg 600
ccggcggtcc agaagcgagt gaaggaggtg ggcacgaagc cggctgcctt catgctgcag 660
attttggact tttacacgaa ggtgtacgaa aaggagcgca acacgtacgc gacggtgcac 720
gatccctgcg ctgtggcgta cgtgattgac cccaccgtga tgacgacgga gcaagtgcca 780
gtggacatcg agctcaatgg ggcactgacg actgggatga cggtcgcgga cttccgctac 840
ccacggccaa agcactgcca cacgcaggtg gctgtgaagc tggacttcga caagttttgg 900
tgcctcgtga ttgacgcact caagcgcatc ggcgatcctc aatccgccgg tggccgtgag 960
accgcgccga cgaacctgat tcgtcgccgc aacaaggacg agacaaacgg ggatgtcagc 1020
gccgccgccg accgcttccg cgaccgcttc gagaaggcaa ccctcgagga gcgcaaggcc 1080
gccaccacga cgatggtcaa cgagtactac gacctggtga cggacttcta cgagtacggc 1140
tggggccaga acttccattt cgcgccgcgc tacgccggcg agaccttctt cgagtccctc 1200
gcgcgccacg agtacttcct ggccgctcgc ggcggcttca tggagggcga ccacatcgtc 1260
gacgtgggct gcggcgtcgg cggtccggcg cgcaacatgg ttcgcctcac gcgctgcaac 1320
gtcatcggcg tcaacaacaa cgattaccag atcagccgcg ctcgccgtca tgacgcgctc 1380
gccggtatga gctccaagat cgactacgtc aagaccgact tctgcaacat gagcttagcc 1440
gacaacacct tcgacggcgc ctacgccatc gaggccacct gccacgcaaa ggacaaggtc 1500
aagtgctata gcgaggtctt ccgtgtcatc aagcccggca cctgctttgt cctgtacgag 1560
tggtgcatga ccgacaagta caaccccaat gacgagtacc accgcacaat caagcaccgc 1620
atcgagctgg gcgacggcct gccggagatg gagacgtgca aacaggtgat cgagtacatg 1680
aagcaggccg gcttcgtggt ggaggaggcc atagacgtca tcagtcagtt cgagtccagc 1740
cccatcaaga gtatcccgtg gtaccagccg ctggtcggcg actattcgtc cctgcagggc 1800
ctgcgctcta ccccgattgg ccgcatcctc acgaacgtca tgtgtcgcgt gctggagttc 1860
gtgcgcctag ctccgaaggg cacgtacaag gcgacggaga ttttggagga ggctgcggaa 1920
agcctggtgg tgggcggtca gctcggcatc ttcacgccgt ccttctacat ccgcgctcgc 1980
aagccgtcca agcaggcttc ggcggtcggc aacatcgagt cgcagtgggc ccgtgccggc 2040
cacggcttgg tgagcctgtc ggagcagcag ctggtgagct gcgatgacaa agacaatggc 2100
tgcaacggcg ggctgatgct gcaggcgttc gagtggctgc tgcgacacat gtacgggatc 2160
gtgttcacgg agaagagcta cccctacacg tccggcaacg gtgatgtggc cgagtgcttg 2220
aacagcagta aactcgttcc cggcgcgcaa atcgacggct acgtgatgat cccgagcaac 2280
gaaacggtta tggctgcgtg gcttgcggag aatggcccca tcgcgattgc ggtcgacgcc 2340
agctccttca tgtcttacca gagcggcgtg ctgaccagct gcgctggcga tgcactgaac 2400
cacggcgtgc tgctcgtcgg gtacaacaag accggtgggg ttccgtactg ggtgatcaag 2460
aactcgtggg gtgaggactg gggcgagaag ggctacgtgc gcgtggtcat ggggctgaac 2520
gcgtgcctgc tcagtgaata ccccgtgtcc gcgcatgtgc cgcggagtct cacccctggc 2580
ccgggcacgg agagcgagga gcgcgcccct aaacgggtga cggtggagca gatgatgtgc 2640
accgatatgt actgcaggga ggggtgcaag aagagtcttc tcaccgcgaa cgtgtgctac 2700
aagaacgggg gaggcggctc ctctatgacg aagtgcggtc cgcagaaggt gctgatgtgc 2760
tcgtactcga accctcattg ctttggtcct gggctgtgcc tcgagactcc tgatggcaag 2820
tgcgcgccgt acttcttggg ctcgatcatg aacacctgcc agtacacg              2868

<210> 2
<211> 956
<212> PRT
<213> Artificial Sequence

<220> 
<223> NSC Fusion Polypeptide

<400> 2
Met Pro Arg Lys Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala
 1               5                  10                  15      
Val Ala Ile Phe Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala
            20                  25                  30          
Ile Thr Thr Val Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn
        35                  40                  45              
Ala Arg Leu Val Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala
    50                  55                  60                  
Ala Gly Cys Thr Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln
65                  70                  75                  80  
Ile His Gly Glu Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe
                85                  90                  95      
Lys Thr Lys Leu Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu
            100                 105                 110         
Ile Met Ser His Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly
        115                 120                 125             
Leu Thr Asn Ile Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp
    130                 135                 140                 
Arg Val Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn
145                 150                 155                 160 
Ala Ser Pro Val Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala
                165                 170                 175     
His Ile Val Phe Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp
            180                 185                 190         
Leu Thr His Gln Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys
        195                 200                 205             
Glu Val Gly Thr Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe
    210                 215                 220                 
Tyr Thr Lys Val Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His
225                 230                 235                 240 
Asp Pro Cys Ala Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr
                245                 250                 255     
Glu Gln Val Pro Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly
            260                 265                 270         
Met Thr Val Ala Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr
        275                 280                 285             
Gln Val Ala Val Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile
    290                 295                 300                 
Asp Ala Leu Lys Arg Ile Gly Asp Pro Gln Ser Ala Gly Gly Arg Glu
305                 310                 315                 320 
Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn
                325                 330                 335     
Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys
            340                 345                 350         
Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu
        355                 360                 365             
Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn
    370                 375                 380                 
Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu
385                 390                 395                 400 
Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly
                405                 410                 415     
Asp His Ile Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn
            420                 425                 430         
Met Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp
        435                 440                 445             
Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser
    450                 455                 460                 
Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala
465                 470                 475                 480 
Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala
                485                 490                 495     
Lys Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro
            500                 505                 510         
Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn
        515                 520                 525             
Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly
    530                 535                 540                 
Asp Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met
545                 550                 555                 560 
Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln
                565                 570                 575     
Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val
            580                 585                 590         
Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg
        595                 600                 605             
Ile Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala
    610                 615                 620                 
Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu
625                 630                 635                 640 
Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr
                645                 650                 655     
Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Ser Ala Val Gly Asn Ile
            660                 665                 670         
Glu Ser Gln Trp Ala Arg Ala Gly His Gly Leu Val Ser Leu Ser Glu
        675                 680                 685             
Gln Gln Leu Val Ser Cys Asp Asp Lys Asp Asn Gly Cys Asn Gly Gly
    690                 695                 700                 
Leu Met Leu Gln Ala Phe Glu Trp Leu Leu Arg His Met Tyr Gly Ile
705                 710                 715                 720 
Val Phe Thr Glu Lys Ser Tyr Pro Tyr Thr Ser Gly Asn Gly Asp Val
                725                 730                 735     
Ala Glu Cys Leu Asn Ser Ser Lys Leu Val Pro Gly Ala Gln Ile Asp
            740                 745                 750         
Gly Tyr Val Met Ile Pro Ser Asn Glu Thr Val Met Ala Ala Trp Leu
        755                 760                 765             
Ala Glu Asn Gly Pro Ile Ala Ile Ala Val Asp Ala Ser Ser Phe Met
    770                 775                 780                 
Ser Tyr Gln Ser Gly Val Leu Thr Ser Cys Ala Gly Asp Ala Leu Asn
785                 790                 795                 800 
His Gly Val Leu Leu Val Gly Tyr Asn Lys Thr Gly Gly Val Pro Tyr
                805                 810                 815     
Trp Val Ile Lys Asn Ser Trp Gly Glu Asp Trp Gly Glu Lys Gly Tyr
            820                 825                 830         
Val Arg Val Val Met Gly Leu Asn Ala Cys Leu Leu Ser Glu Tyr Pro
        835                 840                 845             
Val Ser Ala His Val Pro Arg Ser Leu Thr Pro Gly Pro Gly Thr Glu
    850                 855                 860                 
Ser Glu Glu Arg Ala Pro Lys Arg Val Thr Val Glu Gln Met Met Cys
865                 870                 875                 880 
Thr Asp Met Tyr Cys Arg Glu Gly Cys Lys Lys Ser Leu Leu Thr Ala
                885                 890                 895     
Asn Val Cys Tyr Lys Asn Gly Gly Gly Gly Ser Ser Met Thr Lys Cys
            900                 905                 910         
Gly Pro Gln Lys Val Leu Met Cys Ser Tyr Ser Asn Pro His Cys Phe
        915                 920                 925             
Gly Pro Gly Leu Cys Leu Glu Thr Pro Asp Gly Lys Cys Ala Pro Tyr
    930                 935                 940                 
Phe Leu Gly Ser Ile Met Asn Thr Cys Gln Tyr Thr
945                 950                 955     


<210> 3
<211> 2640
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding NSA Fusion Polypeptide

<400> 3
atgccgcgca agattattct cgattgtgat cccgggatcg atgatgccgt ggccatcttt 60
ctcgcccacg gcaacccgga ggtcgagctg ctggccatta cgacggtggt gggcaaccag 120
accctggaga aggtgacccg gaacgcgcgg ctggtagctg acgtagccgg catcgttggt 180
gtgcccgtcg cggctggttg caccaagccc ctcgtgcgcg gtgtgcggaa tgcctctcag 240
attcatggcg aaaccggcat gggtaacgtc tcctacccac cagagttcaa gacaaagttg 300
gacggccgtc atgcagtgca gctgatcatc gaccttatca tgtcgcacga gccgaagacg 360
atcacgcttg tgcctacggg tggcctgacg aacattgcga tggctgtccg tcttgagccg 420
cgcatcgtgg accgtgtgaa ggaggtggtt ctgatgggtg gcggctacca tactggtaat 480
gcgtcccctg tagcggagtt caacgtcttc gtcgacccgg aggcggcgca cattgtgttc 540
aacgagagct ggaacgtaac gatggtgggg ctggacctaa cgcaccaggc actcgccacg 600
ccggcggtcc agaagcgagt gaaggaggtg ggcacgaagc cggctgcctt catgctgcag 660
attttggact tttacacgaa ggtgtacgaa aaggagcgca acacgtacgc gacggtgcac 720
gatccctgcg ctgtggcgta cgtgattgac cccaccgtga tgacgacgga gcaagtgcca 780
gtggacatcg agctcaatgg ggcactgacg actgggatga cggtcgcgga cttccgctac 840
ccacggccaa agcactgcca cacgcaggtg gctgtgaagc tggacttcga caagttttgg 900
tgcctcgtga ttgacgcact caagcgcatc ggcgatcctc aatccgccgg tggccgtgag 960
accgcgccga cgaacctgat tcgtcgccgc aacaaggacg agacaaacgg ggatgtcagc 1020
gccgccgccg accgcttccg cgaccgcttc gagaaggcaa ccctcgagga gcgcaaggcc 1080
gccaccacga cgatggtcaa cgagtactac gacctggtga cggacttcta cgagtacggc 1140
tggggccaga acttccattt cgcgccgcgc tacgccggcg agaccttctt cgagtccctc 1200
gcgcgccacg agtacttcct ggccgctcgc ggcggcttca tggagggcga ccacatcgtc 1260
gacgtgggct gcggcgtcgg cggtccggcg cgcaacatgg ttcgcctcac gcgctgcaac 1320
gtcatcggcg tcaacaacaa cgattaccag atcagccgcg ctcgccgtca tgacgcgctc 1380
gccggtatga gctccaagat cgactacgtc aagaccgact tctgcaacat gagcttagcc 1440
gacaacacct tcgacggcgc ctacgccatc gaggccacct gccacgcaaa ggacaaggtc 1500
aagtgctata gcgaggtctt ccgtgtcatc aagcccggca cctgctttgt cctgtacgag 1560
tggtgcatga ccgacaagta caaccccaat gacgagtacc accgcacaat caagcaccgc 1620
atcgagctgg gcgacggcct gccggagatg gagacgtgca aacaggtgat cgagtacatg 1680
aagcaggccg gcttcgtggt ggaggaggcc atagacgtca tcagtcagtt cgagtccagc 1740
cccatcaaga gtatcccgtg gtaccagccg ctggtcggcg actattcgtc cctgcagggc 1800
ctgcgctcta ccccgattgg ccgcatcctc acgaacgtca tgtgtcgcgt gctggagttc 1860
gtgcgcctag ctccgaaggg cacgtacaag gcgacggaga ttttggagga ggctgcggaa 1920
agcctggtgg tgggcggtca gctcggcatc ttcacgccgt ccttctacat ccgcgctcgc 1980
aagccgtcca agcaggctag cgcctccgct gagccgcaca aggcggccgt tgacgtcggc 2040
ccgctgagcg ttggcccgca gagcgtcggc ccgctgagcg ttggcccgca ggcggttggc 2100
ccgctgagcg ttggcccgca gagcgtcggc ccgctgagcg ttggcccgca ggcggttggc 2160
ccgctgagcg ttggcccgca gagcgttggc ccgctgagcg ttggcccgct gagcgttggc 2220
ccgcagagcg ttggcccgct gagcgttggc agccagagcg tcggcccgct gagcgttggt 2280
ccgcagagcg tcggcccgct gagcgttggc ccgcaggcgg ttggcccgct gagcgttggc 2340
ccgcagagcg tcggcccgct gagcgttggc ccgcaggcgg ttggcccgct gagcgttggc 2400
ccgcagagcg ttggcccgct gagcgttggc ccgcagagcg ttggcccgct gagcgttggc 2460
agccagagcg tcggcccgct gagcgttggt ccgcagagcg tcggcccgct gagcgttggc 2520
ccgcagagcg tcggcccgct gagcgttggc ccgcagagcg tcggcccgct gagcgttggt 2580
ccgcagagcg ttggcccgct gagcgttggc ccgcagagcg ttgacgttag cccggtgagc 2640


<210> 4
<211> 880
<212> PRT
<213> Artificial Sequence

<220> 
<223> NSA Fusion Polypeptide

<400> 4
Met Pro Arg Lys Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala
 1               5                  10                  15      
Val Ala Ile Phe Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala
            20                  25                  30          
Ile Thr Thr Val Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn
        35                  40                  45              
Ala Arg Leu Val Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala
    50                  55                  60                  
Ala Gly Cys Thr Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln
65                  70                  75                  80  
Ile His Gly Glu Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe
                85                  90                  95      
Lys Thr Lys Leu Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu
            100                 105                 110         
Ile Met Ser His Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly
        115                 120                 125             
Leu Thr Asn Ile Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp
    130                 135                 140                 
Arg Val Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn
145                 150                 155                 160 
Ala Ser Pro Val Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala
                165                 170                 175     
His Ile Val Phe Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp
            180                 185                 190         
Leu Thr His Gln Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys
        195                 200                 205             
Glu Val Gly Thr Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe
    210                 215                 220                 
Tyr Thr Lys Val Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His
225                 230                 235                 240 
Asp Pro Cys Ala Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr
                245                 250                 255     
Glu Gln Val Pro Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly
            260                 265                 270         
Met Thr Val Ala Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr
        275                 280                 285             
Gln Val Ala Val Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile
    290                 295                 300                 
Asp Ala Leu Lys Arg Ile Gly Asp Pro Gln Ser Ala Gly Gly Arg Glu
305                 310                 315                 320 
Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn
                325                 330                 335     
Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys
            340                 345                 350         
Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu
        355                 360                 365             
Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn
    370                 375                 380                 
Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu
385                 390                 395                 400 
Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly
                405                 410                 415     
Asp His Ile Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn
            420                 425                 430         
Met Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp
        435                 440                 445             
Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser
    450                 455                 460                 
Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala
465                 470                 475                 480 
Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala
                485                 490                 495     
Lys Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro
            500                 505                 510         
Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn
        515                 520                 525             
Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly
    530                 535                 540                 
Asp Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met
545                 550                 555                 560 
Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln
                565                 570                 575     
Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val
            580                 585                 590         
Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg
        595                 600                 605             
Ile Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala
    610                 615                 620                 
Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu
625                 630                 635                 640 
Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr
                645                 650                 655     
Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Ser Ala Ser Ala Glu Pro
            660                 665                 670         
His Lys Ala Ala Val Asp Val Gly Pro Leu Ser Val Gly Pro Gln Ser
        675                 680                 685             
Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val
    690                 695                 700                 
Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly
705                 710                 715                 720 
Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro
                725                 730                 735     
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln
            740                 745                 750         
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser
        755                 760                 765             
Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
    770                 775                 780                 
Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly
785                 790                 795                 800 
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
                805                 810                 815     
Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
            820                 825                 830         
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser
        835                 840                 845             
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
    850                 855                 860                 
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Asp Val Ser Pro Val Ser
865                 870                 875                 880 


<210> 5
<211> 2706
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding NSAfl Fusion Polypeptide

<400> 5
atgccgcgca agattattct cgattgtgat cccgggatcg atgatgccgt ggccatcttt 60
ctcgcccacg gcaacccgga ggtcgagctg ctggccatta cgacggtggt gggcaaccag 120
accctggaga aggtgacccg gaacgcgcgg ctggtagctg acgtagccgg catcgttggt 180
gtgcccgtcg cggctggttg caccaagccc ctcgtgcgcg gtgtgcggaa tgcctctcag 240
attcatggcg aaaccggcat gggtaacgtc tcctacccac cagagttcaa gacaaagttg 300
gacggccgtc atgcagtgca gctgatcatc gaccttatca tgtcgcacga gccgaagacg 360
atcacgcttg tgcctacggg tggcctgacg aacattgcga tggctgtccg tcttgagccg 420
cgcatcgtgg accgtgtgaa ggaggtggtt ctgatgggtg gcggctacca tactggtaat 480
gcgtcccctg tagcggagtt caacgtcttc gtcgacccgg aggcggcgca cattgtgttc 540
aacgagagct ggaacgtaac gatggtgggg ctggacctaa cgcaccaggc actcgccacg 600
ccggcggtcc agaagcgagt gaaggaggtg ggcacgaagc cggctgcctt catgctgcag 660
attttggact tttacacgaa ggtgtacgaa aaggagcgca acacgtacgc gacggtgcac 720
gatccctgcg ctgtggcgta cgtgattgac cccaccgtga tgacgacgga gcaagtgcca 780
gtggacatcg agctcaatgg ggcactgacg actgggatga cggtcgcgga cttccgctac 840
ccacggccaa agcactgcca cacgcaggtg gctgtgaagc tggacttcga caagttttgg 900
tgcctcgtga ttgacgcact caagcgcatc ggcgatcctc aatccgccgg tggccgtgag 960
accgcgccga cgaacctgat tcgtcgccgc aacaaggacg agacaaacgg ggatgtcagc 1020
gccgccgccg accgcttccg cgaccgcttc gagaaggcaa ccctcgagga gcgcaaggcc 1080
gccaccacga cgatggtcaa cgagtactac gacctggtga cggacttcta cgagtacggc 1140
tggggccaga acttccattt cgcgccgcgc tacgccggcg agaccttctt cgagtccctc 1200
gcgcgccacg agtacttcct ggccgctcgc ggcggcttca tggagggcga ccacatcgtc 1260
gacgtgggct gcggcgtcgg cggtccggcg cgcaacatgg ttcgcctcac gcgctgcaac 1320
gtcatcggcg tcaacaacaa cgattaccag atcagccgcg ctcgccgtca tgacgcgctc 1380
gccggtatga gctccaagat cgactacgtc aagaccgact tctgcaacat gagcttagcc 1440
gacaacacct tcgacggcgc ctacgccatc gaggccacct gccacgcaaa ggacaaggtc 1500
aagtgctata gcgaggtctt ccgtgtcatc aagcccggca cctgctttgt cctgtacgag 1560
tggtgcatga ccgacaagta caaccccaat gacgagtacc accgcacaat caagcaccgc 1620
atcgagctgg gcgacggcct gccggagatg gagacgtgca aacaggtgat cgagtacatg 1680
aagcaggccg gcttcgtggt ggaggaggcc atagacgtca tcagtcagtt cgagtccagc 1740
cccatcaaga gtatcccgtg gtaccagccg ctggtcggcg actattcgtc cctgcagggc 1800
ctgcgctcta ccccgattgg ccgcatcctc acgaacgtca tgtgtcgcgt gctggagttc 1860
gtgcgcctag ctccgaaggg cacgtacaag gcgacggaga ttttggagga ggctgcggaa 1920
agcctggtgg tgggcggtca gctcggcatc ttcacgccgt ccttctacat ccgcgctcgc 1980
aagccgtcca agcaggctat gaagatccgc agcgtgcgtc cgcttgtggt gttgctggtg 2040
tccgtcgcgg cggtgctcgc actcagcgcc tccgctgagc cgcacaaggc ggccgttgac 2100
gtcggcccgc tgagcgttgg cccgcagagc gtcggcccgc tgagcgttgg cccgcaggcg 2160
gttggcccgc tgagcgttgg cccgcagagc gtcggcccgc tgagcgttgg cccgcaggcg 2220
gttggcccgc tgagcgttgg cccgcagagc gttggcccgc tgagcgttgg cccgctgagc 2280
gttggcccgc agagcgttgg cccgctgagc gttggcagcc agagcgtcgg cccgctgagc 2340
gttggtccgc agagcgtcgg cccgctgagc gttggcccgc aggcggttgg cccgctgagc 2400
gttggcccgc agagcgtcgg cccgctgagc gttggcccgc aggcggttgg cccgctgagc 2460
gttggcccgc agagcgttgg cccgctgagc gttggcccgc agagcgttgg cccgctgagc 2520
gttggcagcc agagcgtcgg cccgctgagc gttggtccgc agagcgtcgg cccgctgagc 2580
gttggcccgc agagcgtcgg cccgctgagc gttggcccgc agagcgtcgg cccgctgagc 2640
gttggtccgc agagcgttgg cccgctgagc gttggcccgc agagcgttga cgttagcccg 2700
gtgagc                                                            2706

<210> 6
<211> 902
<212> PRT
<213> Artificial Sequence

<220> 
<223> NSAfl Fusion Polypeptide

<400> 6
Met Pro Arg Lys Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala
 1               5                  10                  15      
Val Ala Ile Phe Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala
            20                  25                  30          
Ile Thr Thr Val Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn
        35                  40                  45              
Ala Arg Leu Val Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala
    50                  55                  60                  
Ala Gly Cys Thr Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln
65                  70                  75                  80  
Ile His Gly Glu Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe
                85                  90                  95      
Lys Thr Lys Leu Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu
            100                 105                 110         
Ile Met Ser His Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly
        115                 120                 125             
Leu Thr Asn Ile Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp
    130                 135                 140                 
Arg Val Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn
145                 150                 155                 160 
Ala Ser Pro Val Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala
                165                 170                 175     
His Ile Val Phe Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp
            180                 185                 190         
Leu Thr His Gln Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys
        195                 200                 205             
Glu Val Gly Thr Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe
    210                 215                 220                 
Tyr Thr Lys Val Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His
225                 230                 235                 240 
Asp Pro Cys Ala Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr
                245                 250                 255     
Glu Gln Val Pro Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly
            260                 265                 270         
Met Thr Val Ala Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr
        275                 280                 285             
Gln Val Ala Val Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile
    290                 295                 300                 
Asp Ala Leu Lys Arg Ile Gly Asp Pro Gln Ser Ala Gly Gly Arg Glu
305                 310                 315                 320 
Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn
                325                 330                 335     
Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys
            340                 345                 350         
Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu
        355                 360                 365             
Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn
    370                 375                 380                 
Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu
385                 390                 395                 400 
Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly
                405                 410                 415     
Asp His Ile Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn
            420                 425                 430         
Met Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp
        435                 440                 445             
Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser
    450                 455                 460                 
Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala
465                 470                 475                 480 
Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala
                485                 490                 495     
Lys Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro
            500                 505                 510         
Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn
        515                 520                 525             
Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly
    530                 535                 540                 
Asp Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met
545                 550                 555                 560 
Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln
                565                 570                 575     
Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val
            580                 585                 590         
Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg
        595                 600                 605             
Ile Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala
    610                 615                 620                 
Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu
625                 630                 635                 640 
Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr
                645                 650                 655     
Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Met Lys Ile Arg Ser Val
            660                 665                 670         
Arg Pro Leu Val Val Leu Leu Val Ser Val Ala Ala Val Leu Ala Leu
        675                 680                 685             
Ser Ala Ser Ala Glu Pro His Lys Ala Ala Val Asp Val Gly Pro Leu
    690                 695                 700                 
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala
705                 710                 715                 720 
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
                725                 730                 735     
Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly
            740                 745                 750         
Pro Leu Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
        755                 760                 765             
Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
    770                 775                 780                 
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser
785                 790                 795                 800 
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val
                805                 810                 815     
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
            820                 825                 830         
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro
        835                 840                 845             
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
    850                 855                 860                 
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser
865                 870                 875                 880 
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
                885                 890                 895     
Asp Val Ser Pro Val Ser
            900         


<210> 7
<211> 2778
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding HNSA Fusion Polypeptide

<400> 7
atggcctctt ctcgctctgc tccccgcaag gcttcccacg cgcacaagtc gcaccgcaag 60
ccgaagcgct cgtggaacgt gtacgtgggc cgctcgctga aggcgatcaa cgcccagatg 120
tcgatgtcgc accgcacgat gccgcgcaag attattctcg attgtgatcc cgggatcgat 180
gatgccgtgg ccatctttct cgcccacggc aacccggagg tcgagctgct ggccattacg 240
acggtggtgg gcaaccagac cctggagaag gtgacccgga acgcgcggct ggtagctgac 300
gtagccggca tcgttggtgt gcccgtcgcg gctggttgca ccaagcccct cgtgcgcggt 360
gtgcggaatg cctctcagat tcatggcgaa accggcatgg gtaacgtctc ctacccacca 420
gagttcaaga caaagttgga cggccgtcat gcagtgcagc tgatcatcga ccttatcatg 480
tcgcacgagc cgaagacgat cacgcttgtg cctacgggtg gcctgacgaa cattgcgatg 540
gctgtccgtc ttgagccgcg catcgtggac cgtgtgaagg aggtggttct gatgggtggc 600
ggctaccata ctggtaatgc gtcccctgta gcggagttca acgtcttcgt cgacccggag 660
gcggcgcaca ttgtgttcaa cgagagctgg aacgtaacga tggtggggct ggacctaacg 720
caccaggcac tcgccacgcc ggcggtccag aagcgagtga aggaggtggg cacgaagccg 780
gctgccttca tgctgcagat tttggacttt tacacgaagg tgtacgaaaa ggagcgcaac 840
acgtacgcga cggtgcacga tccctgcgct gtggcgtacg tgattgaccc caccgtgatg 900
acgacggagc aagtgccagt ggacatcgag ctcaatgggg cactgacgac tgggatgacg 960
gtcgcggact tccgctaccc acggccaaag cactgccaca cgcaggtggc tgtgaagctg 1020
gacttcgaca agttttggtg cctcgtgatt gacgcactca agcgcatcgg cgatcctcaa 1080
tccgccggtg gccgtgagac cgcgccgacg aacctgattc gtcgccgcaa caaggacgag 1140
acaaacgggg atgtcagcgc cgccgccgac cgcttccgcg accgcttcga gaaggcaacc 1200
ctcgaggagc gcaaggccgc caccacgacg atggtcaacg agtactacga cctggtgacg 1260
gacttctacg agtacggctg gggccagaac ttccatttcg cgccgcgcta cgccggcgag 1320
accttcttcg agtccctcgc gcgccacgag tacttcctgg ccgctcgcgg cggcttcatg 1380
gagggcgacc acatcgtcga cgtgggctgc ggcgtcggcg gtccggcgcg caacatggtt 1440
cgcctcacgc gctgcaacgt catcggcgtc aacaacaacg attaccagat cagccgcgct 1500
cgccgtcatg acgcgctcgc cggtatgagc tccaagatcg actacgtcaa gaccgacttc 1560
tgcaacatga gcttagccga caacaccttc gacggcgcct acgccatcga ggccacctgc 1620
cacgcaaagg acaaggtcaa gtgctatagc gaggtcttcc gtgtcatcaa gcccggcacc 1680
tgctttgtcc tgtacgagtg gtgcatgacc gacaagtaca accccaatga cgagtaccac 1740
cgcacaatca agcaccgcat cgagctgggc gacggcctgc cggagatgga gacgtgcaaa 1800
caggtgatcg agtacatgaa gcaggccggc ttcgtggtgg aggaggccat agacgtcatc 1860
agtcagttcg agtccagccc catcaagagt atcccgtggt accagccgct ggtcggcgac 1920
tattcgtccc tgcagggcct gcgctctacc ccgattggcc gcatcctcac gaacgtcatg 1980
tgtcgcgtgc tggagttcgt gcgcctagct ccgaagggca cgtacaaggc gacggagatt 2040
ttggaggagg ctgcggaaag cctggtggtg ggcggtcagc tcggcatctt cacgccgtcc 2100
ttctacatcc gcgctcgcaa gccgtccaag caggctagcg cctccgctga gccgcacaag 2160
gcggccgttg acgtcggccc gctgagcgtt ggcccgcaga gcgtcggccc gctgagcgtt 2220
ggcccgcagg cggttggccc gctgagcgtt ggcccgcaga gcgtcggccc gctgagcgtt 2280
ggcccgcagg cggttggccc gctgagcgtt ggcccgcaga gcgttggccc gctgagcgtt 2340
ggcccgctga gcgttggccc gcagagcgtt ggcccgctga gcgttggcag ccagagcgtc 2400
ggcccgctga gcgttggtcc gcagagcgtc ggcccgctga gcgttggccc gcaggcggtt 2460
ggcccgctga gcgttggccc gcagagcgtc ggcccgctga gcgttggccc gcaggcggtt 2520
ggcccgctga gcgttggccc gcagagcgtt ggcccgctga gcgttggccc gcagagcgtt 2580
ggcccgctga gcgttggcag ccagagcgtc ggcccgctga gcgttggtcc gcagagcgtc 2640
ggcccgctga gcgttggccc gcagagcgtc ggcccgctga gcgttggccc gcagagcgtc 2700
ggcccgctga gcgttggtcc gcagagcgtt ggcccgctga gcgttggccc gcagagcgtt 2760
gacgttagcc cggtgagc                                               2778

<210> 8
<211> 926
<212> PRT
<213> Artificial Sequence

<220> 
<223> HNSA Fusion Polypeptide

<400> 8
Met Ala Ser Ser Arg Ser Ala Pro Arg Lys Ala Ser His Ala His Lys
 1               5                  10                  15      
Ser His Arg Lys Pro Lys Arg Ser Trp Asn Val Tyr Val Gly Arg Ser
            20                  25                  30          
Leu Lys Ala Ile Asn Ala Gln Met Ser Met Ser His Arg Thr Met Pro
        35                  40                  45              
Arg Lys Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala Val Ala
    50                  55                  60                  
Ile Phe Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala Ile Thr
65                  70                  75                  80  
Thr Val Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn Ala Arg
                85                  90                  95      
Leu Val Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala Ala Gly
            100                 105                 110         
Cys Thr Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln Ile His
        115                 120                 125             
Gly Glu Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe Lys Thr
    130                 135                 140                 
Lys Leu Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu Ile Met
145                 150                 155                 160 
Ser His Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly Leu Thr
                165                 170                 175     
Asn Ile Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp Arg Val
            180                 185                 190         
Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn Ala Ser
        195                 200                 205             
Pro Val Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala His Ile
    210                 215                 220                 
Val Phe Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp Leu Thr
225                 230                 235                 240 
His Gln Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys Glu Val
                245                 250                 255     
Gly Thr Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe Tyr Thr
            260                 265                 270         
Lys Val Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His Asp Pro
        275                 280                 285             
Cys Ala Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr Glu Gln
    290                 295                 300                 
Val Pro Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly Met Thr
305                 310                 315                 320 
Val Ala Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr Gln Val
                325                 330                 335     
Ala Val Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile Asp Ala
            340                 345                 350         
Leu Lys Arg Ile Gly Asp Pro Gln Ser Ala Gly Gly Arg Glu Thr Ala
        355                 360                 365             
Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn Gly Asp
    370                 375                 380                 
Val Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys Ala Thr
385                 390                 395                 400 
Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu Tyr Tyr
                405                 410                 415     
Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn Phe His
            420                 425                 430         
Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu Ala Arg
        435                 440                 445             
His Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly Asp His
    450                 455                 460                 
Ile Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn Met Val
465                 470                 475                 480 
Arg Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp Tyr Gln
                485                 490                 495     
Ile Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser Ser Lys
            500                 505                 510         
Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala Asp Asn
        515                 520                 525             
Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala Lys Asp
    530                 535                 540                 
Lys Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro Gly Thr
545                 550                 555                 560 
Cys Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn Pro Asn
                565                 570                 575     
Asp Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly Asp Gly
            580                 585                 590         
Leu Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met Lys Gln
        595                 600                 605             
Ala Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln Phe Glu
    610                 615                 620                 
Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val Gly Asp
625                 630                 635                 640 
Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg Ile Leu
                645                 650                 655     
Thr Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala Pro Lys
            660                 665                 670         
Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu Ser Leu
        675                 680                 685             
Val Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr Ile Arg
    690                 695                 700                 
Ala Arg Lys Pro Ser Lys Gln Ala Ser Ala Ser Ala Glu Pro His Lys
705                 710                 715                 720 
Ala Ala Val Asp Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly
                725                 730                 735     
Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro
            740                 745                 750         
Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu
        755                 760                 765             
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Leu Ser
    770                 775                 780                 
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln Ser Val
785                 790                 795                 800 
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
                805                 810                 815     
Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
            820                 825                 830         
Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln
        835                 840                 845             
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser
    850                 855                 860                 
Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
865                 870                 875                 880 
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
                885                 890                 895     
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
            900                 905                 910         
Leu Ser Val Gly Pro Gln Ser Val Asp Val Ser Pro Val Ser
        915                 920                 925     


<210> 9
<211> 3099
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding 8NSA Fusion Polypeptide

<400> 9
atgaaggaca aggcgacggg caagacgcag aacatcacga tcacggcgaa cggcgggctg 60
tcgaaggagc agatcgagca gatgatccgc gactcggagc agcacgcgga ggccgaccgc 120
gtgaagcgcg agcttgtgga ggtgcgcaac aacgcggaga cgcagctgac aacggcggag 180
aggcagctcg gcgagtggaa gtacgtgagc gatgcggaga aggagaacgt gaagacgctg 240
gtggcggagc tgcgcaaggc gatggagaac ccgaacgtcg cgaaggatga ccttgcggct 300
gcgacggaca agctgcagaa ggctgtgatg gagtgcggcc gcacagagta ccagcaggct 360
gccgcggcca actccggcag caccagcaac tccggtgagc agcagcagca gcagggccaa 420
ggtgagcagc agcagcagca gaacagcgaa gagaagaaga tgccgcgcaa gattattctc 480
gattgtgatc ccgggatcga tgatgccgtg gccatctttc tcgcccacgg caacccggag 540
gtcgagctgc tggccattac gacggtggtg ggcaaccaga ccctggagaa ggtgacccgg 600
aacgcgcggc tggtagctga cgtagccggc atcgttggtg tgcccgtcgc ggctggttgc 660
accaagcccc tcgtgcgcgg tgtgcggaat gcctctcaga ttcatggcga aaccggcatg 720
ggtaacgtct cctacccacc agagttcaag acaaagttgg acggccgtca tgcagtgcag 780
ctgatcatcg accttatcat gtcgcacgag ccgaagacga tcacgcttgt gcctacgggt 840
ggcctgacga acattgcgat ggctgtccgt cttgagccgc gcatcgtgga ccgtgtgaag 900
gaggtggttc tgatgggtgg cggctaccat actggtaatg cgtcccctgt agcggagttc 960
aacgtcttcg tcgacccgga ggcggcgcac attgtgttca acgagagctg gaacgtaacg 1020
atggtggggc tggacctaac gcaccaggca ctcgccacgc cggcggtcca gaagcgagtg 1080
aaggaggtgg gcacgaagcc ggctgccttc atgctgcaga ttttggactt ttacacgaag 1140
gtgtacgaaa aggagcgcaa cacgtacgcg acggtgcacg atccctgcgc tgtggcgtac 1200
gtgattgacc ccaccgtgat gacgacggag caagtgccag tggacatcga gctcaatggg 1260
gcactgacga ctgggatgac ggtcgcggac ttccgctacc cacggccaaa gcactgccac 1320
acgcaggtgg ctgtgaagct ggacttcgac aagttttggt gcctcgtgat tgacgcactc 1380
aagcgcatcg gcgatcctca atccgccggt ggccgtgaga ccgcgccgac gaacctgatt 1440
cgtcgccgca acaaggacga gacaaacggg gatgtcagcg ccgccgccga ccgcttccgc 1500
gaccgcttcg agaaggcaac cctcgaggag cgcaaggccg ccaccacgac gatggtcaac 1560
gagtactacg acctggtgac ggacttctac gagtacggct ggggccagaa cttccatttc 1620
gcgccgcgct acgccggcga gaccttcttc gagtccctcg cgcgccacga gtacttcctg 1680
gccgctcgcg gcggcttcat ggagggcgac cacatcgtcg acgtgggctg cggcgtcggc 1740
ggtccggcgc gcaacatggt tcgcctcacg cgctgcaacg tcatcggcgt caacaacaac 1800
gattaccaga tcagccgcgc tcgccgtcat gacgcgctcg ccggtatgag ctccaagatc 1860
gactacgtca agaccgactt ctgcaacatg agcttagccg acaacacctt cgacggcgcc 1920
tacgccatcg aggccacctg ccacgcaaag gacaaggtca agtgctatag cgaggtcttc 1980
cgtgtcatca agcccggcac ctgctttgtc ctgtacgagt ggtgcatgac cgacaagtac 2040
aaccccaatg acgagtacca ccgcacaatc aagcaccgca tcgagctggg cgacggcctg 2100
ccggagatgg agacgtgcaa acaggtgatc gagtacatga agcaggccgg cttcgtggtg 2160
gaggaggcca tagacgtcat cagtcagttc gagtccagcc ccatcaagag tatcccgtgg 2220
taccagccgc tggtcggcga ctattcgtcc ctgcagggcc tgcgctctac cccgattggc 2280
cgcatcctca cgaacgtcat gtgtcgcgtg ctggagttcg tgcgcctagc tccgaagggc 2340
acgtacaagg cgacggagat tttggaggag gctgcggaaa gcctggtggt gggcggtcag 2400
ctcggcatct tcacgccgtc cttctacatc cgcgctcgca agccgtccaa gcaggctagc 2460
gcctccgctg agccgcacaa ggcggccgtt gacgtcggcc cgctgagcgt tggcccgcag 2520
agcgtcggcc cgctgagcgt tggcccgcag gcggttggcc cgctgagcgt tggcccgcag 2580
agcgtcggcc cgctgagcgt tggcccgcag gcggttggcc cgctgagcgt tggcccgcag 2640
agcgttggcc cgctgagcgt tggcccgctg agcgttggcc cgcagagcgt tggcccgctg 2700
agcgttggca gccagagcgt cggcccgctg agcgttggtc cgcagagcgt cggcccgctg 2760
agcgttggcc cgcaggcggt tggcccgctg agcgttggcc cgcagagcgt cggcccgctg 2820
agcgttggcc cgcaggcggt tggcccgctg agcgttggcc cgcagagcgt tggcccgctg 2880
agcgttggcc cgcagagcgt tggcccgctg agcgttggca gccagagcgt cggcccgctg 2940
agcgttggtc cgcagagcgt cggcccgctg agcgttggcc cgcagagcgt cggcccgctg 3000
agcgttggcc cgcagagcgt cggcccgctg agcgttggtc cgcagagcgt tggcccgctg 3060
agcgttggcc cgcagagcgt tgacgttagc ccggtgagc                        3099

<210> 10
<211> 1033
<212> PRT
<213> Artificial Sequence

<220> 
<223> 8NSA Fusion Polypeptide

<400> 10
Met Lys Asp Lys Ala Thr Gly Lys Thr Gln Asn Ile Thr Ile Thr Ala
 1               5                  10                  15      
Asn Gly Gly Leu Ser Lys Glu Gln Ile Glu Gln Met Ile Arg Asp Ser
            20                  25                  30          
Glu Gln His Ala Glu Ala Asp Arg Val Lys Arg Glu Leu Val Glu Val
        35                  40                  45              
Arg Asn Asn Ala Glu Thr Gln Leu Thr Thr Ala Glu Arg Gln Leu Gly
    50                  55                  60                  
Glu Trp Lys Tyr Val Ser Asp Ala Glu Lys Glu Asn Val Lys Thr Leu
65                  70                  75                  80  
Val Ala Glu Leu Arg Lys Ala Met Glu Asn Pro Asn Val Ala Lys Asp
                85                  90                  95      
Asp Leu Ala Ala Ala Thr Asp Lys Leu Gln Lys Ala Val Met Glu Cys
            100                 105                 110         
Gly Arg Thr Glu Tyr Gln Gln Ala Ala Ala Ala Asn Ser Gly Ser Thr
        115                 120                 125             
Ser Asn Ser Gly Glu Gln Gln Gln Gln Gln Gly Gln Gly Glu Gln Gln
    130                 135                 140                 
Gln Gln Gln Asn Ser Glu Glu Lys Lys Met Pro Arg Lys Ile Ile Leu
145                 150                 155                 160 
Asp Cys Asp Pro Gly Ile Asp Asp Ala Val Ala Ile Phe Leu Ala His
                165                 170                 175     
Gly Asn Pro Glu Val Glu Leu Leu Ala Ile Thr Thr Val Val Gly Asn
            180                 185                 190         
Gln Thr Leu Glu Lys Val Thr Arg Asn Ala Arg Leu Val Ala Asp Val
        195                 200                 205             
Ala Gly Ile Val Gly Val Pro Val Ala Ala Gly Cys Thr Lys Pro Leu
    210                 215                 220                 
Val Arg Gly Val Arg Asn Ala Ser Gln Ile His Gly Glu Thr Gly Met
225                 230                 235                 240 
Gly Asn Val Ser Tyr Pro Pro Glu Phe Lys Thr Lys Leu Asp Gly Arg
                245                 250                 255     
His Ala Val Gln Leu Ile Ile Asp Leu Ile Met Ser His Glu Pro Lys
            260                 265                 270         
Thr Ile Thr Leu Val Pro Thr Gly Gly Leu Thr Asn Ile Ala Met Ala
        275                 280                 285             
Val Arg Leu Glu Pro Arg Ile Val Asp Arg Val Lys Glu Val Val Leu
    290                 295                 300                 
Met Gly Gly Gly Tyr His Thr Gly Asn Ala Ser Pro Val Ala Glu Phe
305                 310                 315                 320 
Asn Val Phe Val Asp Pro Glu Ala Ala His Ile Val Phe Asn Glu Ser
                325                 330                 335     
Trp Asn Val Thr Met Val Gly Leu Asp Leu Thr His Gln Ala Leu Ala
            340                 345                 350         
Thr Pro Ala Val Gln Lys Arg Val Lys Glu Val Gly Thr Lys Pro Ala
        355                 360                 365             
Ala Phe Met Leu Gln Ile Leu Asp Phe Tyr Thr Lys Val Tyr Glu Lys
    370                 375                 380                 
Glu Arg Asn Thr Tyr Ala Thr Val His Asp Pro Cys Ala Val Ala Tyr
385                 390                 395                 400 
Val Ile Asp Pro Thr Val Met Thr Thr Glu Gln Val Pro Val Asp Ile
                405                 410                 415     
Glu Leu Asn Gly Ala Leu Thr Thr Gly Met Thr Val Ala Asp Phe Arg
            420                 425                 430         
Tyr Pro Arg Pro Lys His Cys His Thr Gln Val Ala Val Lys Leu Asp
        435                 440                 445             
Phe Asp Lys Phe Trp Cys Leu Val Ile Asp Ala Leu Lys Arg Ile Gly
    450                 455                 460                 
Asp Pro Gln Ser Ala Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile
465                 470                 475                 480 
Arg Arg Arg Asn Lys Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala
                485                 490                 495     
Asp Arg Phe Arg Asp Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys
            500                 505                 510         
Ala Ala Thr Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp
        515                 520                 525             
Phe Tyr Glu Tyr Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr
    530                 535                 540                 
Ala Gly Glu Thr Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu
545                 550                 555                 560 
Ala Ala Arg Gly Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly
                565                 570                 575     
Cys Gly Val Gly Gly Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys
            580                 585                 590         
Asn Val Ile Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg
        595                 600                 605             
Arg His Asp Ala Leu Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys
    610                 615                 620                 
Thr Asp Phe Cys Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala
625                 630                 635                 640 
Tyr Ala Ile Glu Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr
                645                 650                 655     
Ser Glu Val Phe Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr
            660                 665                 670         
Glu Trp Cys Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg
        675                 680                 685             
Thr Ile Lys His Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu
    690                 695                 700                 
Thr Cys Lys Gln Val Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val
705                 710                 715                 720 
Glu Glu Ala Ile Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys
                725                 730                 735     
Ser Ile Pro Trp Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln
            740                 745                 750         
Gly Leu Arg Ser Thr Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys
        755                 760                 765             
Arg Val Leu Glu Phe Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala
    770                 775                 780                 
Thr Glu Ile Leu Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln
785                 790                 795                 800 
Leu Gly Ile Phe Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser
                805                 810                 815     
Lys Gln Ala Ser Ala Ser Ala Glu Pro His Lys Ala Ala Val Asp Val
            820                 825                 830         
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
        835                 840                 845             
Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
    850                 855                 860                 
Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln
865                 870                 875                 880 
Ser Val Gly Pro Leu Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser
                885                 890                 895     
Val Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val
            900                 905                 910         
Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly
        915                 920                 925             
Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro
    930                 935                 940                 
Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu
945                 950                 955                 960 
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln Ser
                965                 970                 975     
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
            980                 985                 990         
Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly
        995                 1000                1005            
Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro
    1010                1015                1020                
Gln Ser Val Asp Val Ser Pro Val Ser
1025                1030            


<210> 11
<211> 3213
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding 21NSA Fusion Polypeptide

<400> 11
atgagcatta tcaaggagga cgacgccgtg ggctgctaca tgacggtgac cctcgtggac 60
gacaccaagg tggagggtac catcttcacc tacaatccca aggaaggcat catagtactt 120
ctgtccctcc gcgacgatca gacgaacatg aagctgatcc gcactccata catcaaagag 180
ttcagtattt cacacgctga ggagggaacg cacctgcctc cggcactgga ctccttcaac 240
gagcttccgt ccatgcatgc cggccgcgac aagtccatct tcaagcacgc cagcacgcag 300
ctcaagaacg ccgaggcgaa ccgcgaaaag cacttcaact ctgtcacgac cgacacaccg 360
attgccacac tcgatgcgta cctcaagctc ctgcggctat accccttcat tgagtggaac 420
agcgacgagg gtgtcatcca ggtctcggat accgtcattg tcgtagggga ccccgactgg 480
cggacgccca aggcgatgct ggtagacggc gcccctgaga aggacagacc gctcgtagac 540
cgcctgcagg ttgcgctcgg aaacggcaag aagatgccgc gcaagattat tctcgattgt 600
gatcccggga tcgatgatgc cgtggccatc tttctcgccc acggcaaccc ggaggtcgag 660
ctgctggcca ttacgacggt ggtgggcaac cagaccctgg agaaggtgac ccggaacgcg 720
cggctggtag ctgacgtagc cggcatcgtt ggtgtgcccg tcgcggctgg ttgcaccaag 780
cccctcgtgc gcggtgtgcg gaatgcctct cagattcatg gcgaaaccgg catgggtaac 840
gtctcctacc caccagagtt caagacaaag ttggacggcc gtcatgcagt gcagctgatc 900
atcgacctta tcatgtcgca cgagccgaag acgatcacgc ttgtgcctac gggtggcctg 960
acgaacattg cgatggctgt ccgtcttgag ccgcgcatcg tggaccgtgt gaaggaggtg 1020
gttctgatgg gtggcggcta ccatactggt aatgcgtccc ctgtagcgga gttcaacgtc 1080
ttcgtcgacc cggaggcggc gcacattgtg ttcaacgaga gctggaacgt aacgatggtg 1140
gggctggacc taacgcacca ggcactcgcc acgccggcgg tccagaagcg agtgaaggag 1200
gtgggcacga agccggctgc cttcatgctg cagattttgg acttttacac gaaggtgtac 1260
gaaaaggagc gcaacacgta cgcgacggtg cacgatccct gcgctgtggc gtacgtgatt 1320
gaccccaccg tgatgacgac ggagcaagtg ccagtggaca tcgagctcaa tggggcactg 1380
acgactggga tgacggtcgc ggacttccgc tacccacggc caaagcactg ccacacgcag 1440
gtggctgtga agctggactt cgacaagttt tggtgcctcg tgattgacgc actcaagcgc 1500
atcggcgatc ctcaatccgc cggtggccgt gagaccgcgc cgacgaacct gattcgtcgc 1560
cgcaacaagg acgagacaaa cggggatgtc agcgccgccg ccgaccgctt ccgcgaccgc 1620
ttcgagaagg caaccctcga ggagcgcaag gccgccacca cgacgatggt caacgagtac 1680
tacgacctgg tgacggactt ctacgagtac ggctggggcc agaacttcca tttcgcgccg 1740
cgctacgccg gcgagacctt cttcgagtcc ctcgcgcgcc acgagtactt cctggccgct 1800
cgcggcggct tcatggaggg cgaccacatc gtcgacgtgg gctgcggcgt cggcggtccg 1860
gcgcgcaaca tggttcgcct cacgcgctgc aacgtcatcg gcgtcaacaa caacgattac 1920
cagatcagcc gcgctcgccg tcatgacgcg ctcgccggta tgagctccaa gatcgactac 1980
gtcaagaccg acttctgcaa catgagctta gccgacaaca ccttcgacgg cgcctacgcc 2040
atcgaggcca cctgccacgc aaaggacaag gtcaagtgct atagcgaggt cttccgtgtc 2100
atcaagcccg gcacctgctt tgtcctgtac gagtggtgca tgaccgacaa gtacaacccc 2160
aatgacgagt accaccgcac aatcaagcac cgcatcgagc tgggcgacgg cctgccggag 2220
atggagacgt gcaaacaggt gatcgagtac atgaagcagg ccggcttcgt ggtggaggag 2280
gccatagacg tcatcagtca gttcgagtcc agccccatca agagtatccc gtggtaccag 2340
ccgctggtcg gcgactattc gtccctgcag ggcctgcgct ctaccccgat tggccgcatc 2400
ctcacgaacg tcatgtgtcg cgtgctggag ttcgtgcgcc tagctccgaa gggcacgtac 2460
aaggcgacgg agattttgga ggaggctgcg gaaagcctgg tggtgggcgg tcagctcggc 2520
atcttcacgc cgtccttcta catccgcgct cgcaagccgt ccaagcaggc tagcgcctcc 2580
gctgagccgc acaaggcggc cgttgacgtc ggcccgctga gcgttggccc gcagagcgtc 2640
ggcccgctga gcgttggccc gcaggcggtt ggcccgctga gcgttggccc gcagagcgtc 2700
ggcccgctga gcgttggccc gcaggcggtt ggcccgctga gcgttggccc gcagagcgtt 2760
ggcccgctga gcgttggccc gctgagcgtt ggcccgcaga gcgttggccc gctgagcgtt 2820
ggcagccaga gcgtcggccc gctgagcgtt ggtccgcaga gcgtcggccc gctgagcgtt 2880
ggcccgcagg cggttggccc gctgagcgtt ggcccgcaga gcgtcggccc gctgagcgtt 2940
ggcccgcagg cggttggccc gctgagcgtt ggcccgcaga gcgttggccc gctgagcgtt 3000
ggcccgcaga gcgttggccc gctgagcgtt ggcagccaga gcgtcggccc gctgagcgtt 3060
ggtccgcaga gcgtcggccc gctgagcgtt ggcccgcaga gcgtcggccc gctgagcgtt 3120
ggcccgcaga gcgtcggccc gctgagcgtt ggtccgcaga gcgttggccc gctgagcgtt 3180
ggcccgcaga gcgttgacgt tagcccggtg agc                              3213

<210> 12
<211> 1071
<212> PRT
<213> Artificial Sequence

<220> 
<223> 21NSA Fusion Polypeptide

<400> 12
Met Ser Ile Ile Lys Glu Asp Asp Ala Val Gly Cys Tyr Met Thr Val
 1               5                  10                  15      
Thr Leu Val Asp Asp Thr Lys Val Glu Gly Thr Ile Phe Thr Tyr Asn
            20                  25                  30          
Pro Lys Glu Gly Ile Ile Val Leu Leu Ser Leu Arg Asp Asp Gln Thr
        35                  40                  45              
Asn Met Lys Leu Ile Arg Thr Pro Tyr Ile Lys Glu Phe Ser Ile Ser
    50                  55                  60                  
His Ala Glu Glu Gly Thr His Leu Pro Pro Ala Leu Asp Ser Phe Asn
65                  70                  75                  80  
Glu Leu Pro Ser Met His Ala Gly Arg Asp Lys Ser Ile Phe Lys His
                85                  90                  95      
Ala Ser Thr Gln Leu Lys Asn Ala Glu Ala Asn Arg Glu Lys His Phe
            100                 105                 110         
Asn Ser Val Thr Thr Asp Thr Pro Ile Ala Thr Leu Asp Ala Tyr Leu
        115                 120                 125             
Lys Leu Leu Arg Leu Tyr Pro Phe Ile Glu Trp Asn Ser Asp Glu Gly
    130                 135                 140                 
Val Ile Gln Val Ser Asp Thr Val Ile Val Val Gly Asp Pro Asp Trp
145                 150                 155                 160 
Arg Thr Pro Lys Ala Met Leu Val Asp Gly Ala Pro Glu Lys Asp Arg
                165                 170                 175     
Pro Leu Val Asp Arg Leu Gln Val Ala Leu Gly Asn Gly Lys Lys Met
            180                 185                 190         
Pro Arg Lys Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala Val
        195                 200                 205             
Ala Ile Phe Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala Ile
    210                 215                 220                 
Thr Thr Val Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn Ala
225                 230                 235                 240 
Arg Leu Val Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala Ala
                245                 250                 255     
Gly Cys Thr Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln Ile
            260                 265                 270         
His Gly Glu Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe Lys
        275                 280                 285             
Thr Lys Leu Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu Ile
    290                 295                 300                 
Met Ser His Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly Leu
305                 310                 315                 320 
Thr Asn Ile Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp Arg
                325                 330                 335     
Val Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn Ala
            340                 345                 350         
Ser Pro Val Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala His
        355                 360                 365             
Ile Val Phe Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp Leu
    370                 375                 380                 
Thr His Gln Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys Glu
385                 390                 395                 400 
Val Gly Thr Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe Tyr
                405                 410                 415     
Thr Lys Val Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His Asp
            420                 425                 430         
Pro Cys Ala Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr Glu
        435                 440                 445             
Gln Val Pro Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly Met
    450                 455                 460                 
Thr Val Ala Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr Gln
465                 470                 475                 480 
Val Ala Val Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile Asp
                485                 490                 495     
Ala Leu Lys Arg Ile Gly Asp Pro Gln Ser Ala Gly Gly Arg Glu Thr
            500                 505                 510         
Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn Gly
        515                 520                 525             
Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys Ala
    530                 535                 540                 
Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu Tyr
545                 550                 555                 560 
Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn Phe
                565                 570                 575     
His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu Ala
            580                 585                 590         
Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly Asp
        595                 600                 605             
His Ile Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn Met
    610                 615                 620                 
Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp Tyr
625                 630                 635                 640 
Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser Ser
                645                 650                 655     
Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala Asp
            660                 665                 670         
Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala Lys
        675                 680                 685             
Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro Gly
    690                 695                 700                 
Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn Pro
705                 710                 715                 720 
Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly Asp
                725                 730                 735     
Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met Lys
            740                 745                 750         
Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln Phe
        755                 760                 765             
Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val Gly
    770                 775                 780                 
Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg Ile
785                 790                 795                 800 
Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala Pro
                805                 810                 815     
Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu Ser
            820                 825                 830         
Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr Ile
        835                 840                 845             
Arg Ala Arg Lys Pro Ser Lys Gln Ala Ser Ala Ser Ala Glu Pro His
    850                 855                 860                 
Lys Ala Ala Val Asp Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
865                 870                 875                 880 
Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly
                885                 890                 895     
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro
            900                 905                 910         
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Leu
        915                 920                 925             
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln Ser
    930                 935                 940                 
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
945                 950                 955                 960 
Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly
                965                 970                 975     
Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro
            980                 985                 990         
Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu
        995                 1000                1005            
Ser Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser
    1010                1015                1020                
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
1025                1030                1035               1040 
Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly
                1045                1050                1055    
Pro Leu Ser Val Gly Pro Gln Ser Val Asp Val Ser Pro Val Ser
            1060                1065                1070    


<210> 13
<211> 3030
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding 821NS Fusion Polypeptide

<400> 13
atgaaggaca aggcgacggg caagacgcag aacatcacga tcacggcgaa cggcgggctg 60
tcgaaggagc agatcgagca gatgatccgc gactcggagc agcacgcgga ggccgaccgc 120
gtgaagcgcg agcttgtgga ggtgcgcaac aacgcggaga cgcagctgac aacggcggag 180
aggcagctcg gcgagtggaa gtacgtgagc gatgcggaga aggagaacgt gaagacgctg 240
gtggcggagc tgcgcaaggc gatggagaac ccgaacgtcg cgaaggatga ccttgcggct 300
gcgacggaca agctgcagaa ggctgtgatg gagtgcggcc gcacagagta ccagcaggct 360
gccgcggcca actccggcag caccagcaac tccggtgagc agcagcagca gcagggccaa 420
ggtgagcagc agcagcagca gaacagcgaa gagaagaaga tgagcattat caaggaggac 480
gacgccgtgg gctgctacat gacggtgacc ctcgtggacg acaccaaggt ggagggtacc 540
atcttcacct acaatcccaa ggaaggcatc atagtacttc tgtccctccg cgacgatcag 600
acgaacatga agctgatccg cactccatac atcaaagagt tcagtatttc acacgctgag 660
gagggaacgc acctgcctcc ggcactggac tccttcaacg agcttccgtc catgcatgcc 720
ggccgcgaca agtccatctt caagcacgcc agcacgcagc tcaagaacgc cgaggcgaac 780
cgcgaaaagc acttcaactc tgtcacgacc gacacaccga ttgccacact cgatgcgtac 840
ctcaagctcc tgcggctata ccccttcatt gagtggaaca gcgacgaggg tgtcatccag 900
gtctcggata ccgtcattgt cgtaggggac cccgactggc ggacgcccaa ggcgatgctg 960
gtagacggcg cccctgagaa ggacagaccg ctcgtagacc gcctgcaggt tgcgctcgga 1020
aacggcaaga agatgccgcg caagattatt ctcgattgtg atcccgggat cgatgatgcc 1080
gtggccatct ttctcgccca cggcaacccg gaggtcgagc tgctggccat tacgacggtg 1140
gtgggcaacc agaccctgga gaaggtgacc cggaacgcgc ggctggtagc tgacgtagcc 1200
ggcatcgttg gtgtgcccgt cgcggctggt tgcaccaagc ccctcgtgcg cggtgtgcgg 1260
aatgcctctc agattcatgg cgaaaccggc atgggtaacg tctcctaccc accagagttc 1320
aagacaaagt tggacggccg tcatgcagtg cagctgatca tcgaccttat catgtcgcac 1380
gagccgaaga cgatcacgct tgtgcctacg ggtggcctga cgaacattgc gatggctgtc 1440
cgtcttgagc cgcgcatcgt ggaccgtgtg aaggaggtgg ttctgatggg tggcggctac 1500
catactggta atgcgtcccc tgtagcggag ttcaacgtct tcgtcgaccc ggaggcggcg 1560
cacattgtgt tcaacgagag ctggaacgta acgatggtgg ggctggacct aacgcaccag 1620
gcactcgcca cgccggcggt ccagaagcga gtgaaggagg tgggcacgaa gccggctgcc 1680
ttcatgctgc agattttgga cttttacacg aaggtgtacg aaaaggagcg caacacgtac 1740
gcgacggtgc acgatccctg cgctgtggcg tacgtgattg accccaccgt gatgacgacg 1800
gagcaagtgc cagtggacat cgagctcaat ggggcactga cgactgggat gacggtcgcg 1860
gacttccgct acccacggcc aaagcactgc cacacgcagg tggctgtgaa gctggacttc 1920
gacaagtttt ggtgcctcgt gattgacgca ctcaagcgca tcggcgatcc tcaatccgcc 1980
ggtggccgtg agaccgcgcc gacgaacctg attcgtcgcc gcaacaagga cgagacaaac 2040
ggggatgtca gcgccgccgc cgaccgcttc cgcgaccgct tcgagaaggc aaccctcgag 2100
gagcgcaagg ccgccaccac gacgatggtc aacgagtact acgacctggt gacggacttc 2160
tacgagtacg gctggggcca gaacttccat ttcgcgccgc gctacgccgg cgagaccttc 2220
ttcgagtccc tcgcgcgcca cgagtacttc ctggccgctc gcggcggctt catggagggc 2280
gaccacatcg tcgacgtggg ctgcggcgtc ggcggtccgg cgcgcaacat ggttcgcctc 2340
acgcgctgca acgtcatcgg cgtcaacaac aacgattacc agatcagccg cgctcgccgt 2400
catgacgcgc tcgccggtat gagctccaag atcgactacg tcaagaccga cttctgcaac 2460
atgagcttag ccgacaacac cttcgacggc gcctacgcca tcgaggccac ctgccacgca 2520
aaggacaagg tcaagtgcta tagcgaggtc ttccgtgtca tcaagcccgg cacctgcttt 2580
gtcctgtacg agtggtgcat gaccgacaag tacaacccca atgacgagta ccaccgcaca 2640
atcaagcacc gcatcgagct gggcgacggc ctgccggaga tggagacgtg caaacaggtg 2700
atcgagtaca tgaagcaggc cggcttcgtg gtggaggagg ccatagacgt catcagtcag 2760
ttcgagtcca gccccatcaa gagtatcccg tggtaccagc cgctggtcgg cgactattcg 2820
tccctgcagg gcctgcgctc taccccgatt ggccgcatcc tcacgaacgt catgtgtcgc 2880
gtgctggagt tcgtgcgcct agctccgaag ggcacgtaca aggcgacgga gattttggag 2940
gaggctgcgg aaagcctggt ggtgggcggt cagctcggca tcttcacgcc gtccttctac 3000
atccgcgctc gcaagccgtc caagcaggct                                  3030

<210> 14
<211> 1010
<212> PRT
<213> Artificial Sequence

<220> 
<223> 821NS Fusion Polypeptide

<400> 14
Met Lys Asp Lys Ala Thr Gly Lys Thr Gln Asn Ile Thr Ile Thr Ala
 1               5                  10                  15      
Asn Gly Gly Leu Ser Lys Glu Gln Ile Glu Gln Met Ile Arg Asp Ser
            20                  25                  30          
Glu Gln His Ala Glu Ala Asp Arg Val Lys Arg Glu Leu Val Glu Val
        35                  40                  45              
Arg Asn Asn Ala Glu Thr Gln Leu Thr Thr Ala Glu Arg Gln Leu Gly
    50                  55                  60                  
Glu Trp Lys Tyr Val Ser Asp Ala Glu Lys Glu Asn Val Lys Thr Leu
65                  70                  75                  80  
Val Ala Glu Leu Arg Lys Ala Met Glu Asn Pro Asn Val Ala Lys Asp
                85                  90                  95      
Asp Leu Ala Ala Ala Thr Asp Lys Leu Gln Lys Ala Val Met Glu Cys
            100                 105                 110         
Gly Arg Thr Glu Tyr Gln Gln Ala Ala Ala Ala Asn Ser Gly Ser Thr
        115                 120                 125             
Ser Asn Ser Gly Glu Gln Gln Gln Gln Gln Gly Gln Gly Glu Gln Gln
    130                 135                 140                 
Gln Gln Gln Asn Ser Glu Glu Lys Lys Met Ser Ile Ile Lys Glu Asp
145                 150                 155                 160 
Asp Ala Val Gly Cys Tyr Met Thr Val Thr Leu Val Asp Asp Thr Lys
                165                 170                 175     
Val Glu Gly Thr Ile Phe Thr Tyr Asn Pro Lys Glu Gly Ile Ile Val
            180                 185                 190         
Leu Leu Ser Leu Arg Asp Asp Gln Thr Asn Met Lys Leu Ile Arg Thr
        195                 200                 205             
Pro Tyr Ile Lys Glu Phe Ser Ile Ser His Ala Glu Glu Gly Thr His
    210                 215                 220                 
Leu Pro Pro Ala Leu Asp Ser Phe Asn Glu Leu Pro Ser Met His Ala
225                 230                 235                 240 
Gly Arg Asp Lys Ser Ile Phe Lys His Ala Ser Thr Gln Leu Lys Asn
                245                 250                 255     
Ala Glu Ala Asn Arg Glu Lys His Phe Asn Ser Val Thr Thr Asp Thr
            260                 265                 270         
Pro Ile Ala Thr Leu Asp Ala Tyr Leu Lys Leu Leu Arg Leu Tyr Pro
        275                 280                 285             
Phe Ile Glu Trp Asn Ser Asp Glu Gly Val Ile Gln Val Ser Asp Thr
    290                 295                 300                 
Val Ile Val Val Gly Asp Pro Asp Trp Arg Thr Pro Lys Ala Met Leu
305                 310                 315                 320 
Val Asp Gly Ala Pro Glu Lys Asp Arg Pro Leu Val Asp Arg Leu Gln
                325                 330                 335     
Val Ala Leu Gly Asn Gly Lys Lys Met Pro Arg Lys Ile Ile Leu Asp
            340                 345                 350         
Cys Asp Pro Gly Ile Asp Asp Ala Val Ala Ile Phe Leu Ala His Gly
        355                 360                 365             
Asn Pro Glu Val Glu Leu Leu Ala Ile Thr Thr Val Val Gly Asn Gln
    370                 375                 380                 
Thr Leu Glu Lys Val Thr Arg Asn Ala Arg Leu Val Ala Asp Val Ala
385                 390                 395                 400 
Gly Ile Val Gly Val Pro Val Ala Ala Gly Cys Thr Lys Pro Leu Val
                405                 410                 415     
Arg Gly Val Arg Asn Ala Ser Gln Ile His Gly Glu Thr Gly Met Gly
            420                 425                 430         
Asn Val Ser Tyr Pro Pro Glu Phe Lys Thr Lys Leu Asp Gly Arg His
        435                 440                 445             
Ala Val Gln Leu Ile Ile Asp Leu Ile Met Ser His Glu Pro Lys Thr
    450                 455                 460                 
Ile Thr Leu Val Pro Thr Gly Gly Leu Thr Asn Ile Ala Met Ala Val
465                 470                 475                 480 
Arg Leu Glu Pro Arg Ile Val Asp Arg Val Lys Glu Val Val Leu Met
                485                 490                 495     
Gly Gly Gly Tyr His Thr Gly Asn Ala Ser Pro Val Ala Glu Phe Asn
            500                 505                 510         
Val Phe Val Asp Pro Glu Ala Ala His Ile Val Phe Asn Glu Ser Trp
        515                 520                 525             
Asn Val Thr Met Val Gly Leu Asp Leu Thr His Gln Ala Leu Ala Thr
    530                 535                 540                 
Pro Ala Val Gln Lys Arg Val Lys Glu Val Gly Thr Lys Pro Ala Ala
545                 550                 555                 560 
Phe Met Leu Gln Ile Leu Asp Phe Tyr Thr Lys Val Tyr Glu Lys Glu
                565                 570                 575     
Arg Asn Thr Tyr Ala Thr Val His Asp Pro Cys Ala Val Ala Tyr Val
            580                 585                 590         
Ile Asp Pro Thr Val Met Thr Thr Glu Gln Val Pro Val Asp Ile Glu
        595                 600                 605             
Leu Asn Gly Ala Leu Thr Thr Gly Met Thr Val Ala Asp Phe Arg Tyr
    610                 615                 620                 
Pro Arg Pro Lys His Cys His Thr Gln Val Ala Val Lys Leu Asp Phe
625                 630                 635                 640 
Asp Lys Phe Trp Cys Leu Val Ile Asp Ala Leu Lys Arg Ile Gly Asp
                645                 650                 655     
Pro Gln Ser Ala Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg
            660                 665                 670         
Arg Arg Asn Lys Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp
        675                 680                 685             
Arg Phe Arg Asp Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala
    690                 695                 700                 
Ala Thr Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe
705                 710                 715                 720 
Tyr Glu Tyr Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala
                725                 730                 735     
Gly Glu Thr Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala
            740                 745                 750         
Ala Arg Gly Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys
        755                 760                 765             
Gly Val Gly Gly Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn
    770                 775                 780                 
Val Ile Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg
785                 790                 795                 800 
His Asp Ala Leu Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr
                805                 810                 815     
Asp Phe Cys Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr
            820                 825                 830         
Ala Ile Glu Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser
        835                 840                 845             
Glu Val Phe Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu
    850                 855                 860                 
Trp Cys Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr
865                 870                 875                 880 
Ile Lys His Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr
                885                 890                 895     
Cys Lys Gln Val Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu
            900                 905                 910         
Glu Ala Ile Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser
        915                 920                 925             
Ile Pro Trp Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly
    930                 935                 940                 
Leu Arg Ser Thr Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg
945                 950                 955                 960 
Val Leu Glu Phe Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr
                965                 970                 975     
Glu Ile Leu Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu
            980                 985                 990         
Gly Ile Phe Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys
        995                 1000                1005            
Gln Ala
    1010


<210> 15
<211> 2136
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding HNS Fusion Polypeptide

<400> 15
atggcctctt ctcgctctgc tccccgcaag gcttcccacg cgcacaagtc gcaccgcaag 60
ccgaagcgct cgtggaacgt gtacgtgggc cgctcgctga aggcgatcaa cgcccagatg 120
tcgatgtcgc accgcacgat gccgcgcaag attattctcg attgtgatcc cgggatcgat 180
gatgccgtgg ccatctttct cgcccacggc aacccggagg tcgagctgct ggccattacg 240
acggtggtgg gcaaccagac cctggagaag gtgacccgga acgcgcggct ggtagctgac 300
gtagccggca tcgttggtgt gcccgtcgcg gctggttgca ccaagcccct cgtgcgcggt 360
gtgcggaatg cctctcagat tcatggcgaa accggcatgg gtaacgtctc ctacccacca 420
gagttcaaga caaagttgga cggccgtcat gcagtgcagc tgatcatcga ccttatcatg 480
tcgcacgagc cgaagacgat cacgcttgtg cctacgggtg gcctgacgaa cattgcgatg 540
gctgtccgtc ttgagccgcg catcgtggac cgtgtgaagg aggtggttct gatgggtggc 600
ggctaccata ctggtaatgc gtcccctgta gcggagttca acgtcttcgt cgacccggag 660
gcggcgcaca ttgtgttcaa cgagagctgg aacgtaacga tggtggggct ggacctaacg 720
caccaggcac tcgccacgcc ggcggtccag aagcgagtga aggaggtggg cacgaagccg 780
gctgccttca tgctgcagat tttggacttt tacacgaagg tgtacgaaaa ggagcgcaac 840
acgtacgcga cggtgcacga tccctgcgct gtggcgtacg tgattgaccc caccgtgatg 900
acgacggagc aagtgccagt ggacatcgag ctcaatgggg cactgacgac tgggatgacg 960
gtcgcggact tccgctaccc acggccaaag cactgccaca cgcaggtggc tgtgaagctg 1020
gacttcgaca agttttggtg cctcgtgatt gacgcactca agcgcatcgg cgatcctcaa 1080
tccgccggtg gccgtgagac cgcgccgacg aacctgattc gtcgccgcaa caaggacgag 1140
acaaacgggg atgtcagcgc cgccgccgac cgcttccgcg accgcttcga gaaggcaacc 1200
ctcgaggagc gcaaggccgc caccacgacg atggtcaacg agtactacga cctggtgacg 1260
gacttctacg agtacggctg gggccagaac ttccatttcg cgccgcgcta cgccggcgag 1320
accttcttcg agtccctcgc gcgccacgag tacttcctgg ccgctcgcgg cggcttcatg 1380
gagggcgacc acatcgtcga cgtgggctgc ggcgtcggcg gtccggcgcg caacatggtt 1440
cgcctcacgc gctgcaacgt catcggcgtc aacaacaacg attaccagat cagccgcgct 1500
cgccgtcatg acgcgctcgc cggtatgagc tccaagatcg actacgtcaa gaccgacttc 1560
tgcaacatga gcttagccga caacaccttc gacggcgcct acgccatcga ggccacctgc 1620
cacgcaaagg acaaggtcaa gtgctatagc gaggtcttcc gtgtcatcaa gcccggcacc 1680
tgctttgtcc tgtacgagtg gtgcatgacc gacaagtaca accccaatga cgagtaccac 1740
cgcacaatca agcaccgcat cgagctgggc gacggcctgc cggagatgga gacgtgcaaa 1800
caggtgatcg agtacatgaa gcaggccggc ttcgtggtgg aggaggccat agacgtcatc 1860
agtcagttcg agtccagccc catcaagagt atcccgtggt accagccgct ggtcggcgac 1920
tattcgtccc tgcagggcct gcgctctacc ccgattggcc gcatcctcac gaacgtcatg 1980
tgtcgcgtgc tggagttcgt gcgcctagct ccgaagggca cgtacaaggc gacggagatt 2040
ttggaggagg ctgcggaaag cctggtggtg ggcggtcagc tcggcatctt cacgccgtcc 2100
ttctacatcc gcgctcgcaa gccgtccaag caggct                           2136

<210> 16
<211> 711
<212> PRT
<213> Artificial Sequence

<220> 
<223> HNS Fusion Polypeptide

<400> 16
Met Ala Ser Ser Arg Ser Ala Pro Arg Lys Ala Ser His Ala His Lys
 1               5                  10                  15      
Ser His Arg Lys Pro Lys Arg Ser Trp Asn Val Tyr Val Gly Arg Ser
            20                  25                  30          
Leu Lys Ala Ile Asn Ala Gln Met Ser Met Ser His Arg Thr Met Pro
        35                  40                  45              
Arg Lys Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala Val Ala
    50                  55                  60                  
Ile Phe Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala Ile Thr
65                  70                  75                  80  
Thr Val Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn Ala Arg
                85                  90                  95      
Leu Val Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala Ala Gly
            100                 105                 110         
Cys Thr Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln Ile His
        115                 120                 125             
Gly Glu Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe Lys Thr
    130                 135                 140                 
Lys Leu Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu Ile Met
145                 150                 155                 160 
Ser His Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly Leu Thr
                165                 170                 175     
Asn Ile Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp Arg Val
            180                 185                 190         
Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn Ala Ser
        195                 200                 205             
Pro Val Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala His Ile
    210                 215                 220                 
Val Phe Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp Leu Thr
225                 230                 235                 240 
His Gln Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys Glu Val
                245                 250                 255     
Gly Thr Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe Tyr Thr
            260                 265                 270         
Lys Val Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His Asp Pro
        275                 280                 285             
Cys Ala Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr Glu Gln
    290                 295                 300                 
Val Pro Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly Met Thr
305                 310                 315                 320 
Val Ala Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr Gln Val
                325                 330                 335     
Ala Val Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile Asp Ala
            340                 345                 350         
Leu Lys Arg Ile Gly Asp Pro Gln Ser Ala Gly Gly Arg Glu Thr Ala
        355                 360                 365             
Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn Gly Asp
    370                 375                 380                 
Val Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys Ala Thr
385                 390                 395                 400 
Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu Tyr Tyr
                405                 410                 415     
Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn Phe His
            420                 425                 430         
Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu Ala Arg
        435                 440                 445             
His Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly Asp His
    450                 455                 460                 
Ile Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn Met Val
465                 470                 475                 480 
Arg Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp Tyr Gln
                485                 490                 495     
Ile Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser Ser Lys
            500                 505                 510         
Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala Asp Asn
        515                 520                 525             
Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala Lys Asp
    530                 535                 540                 
Lys Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro Gly Thr
545                 550                 555                 560 
Cys Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn Pro Asn
                565                 570                 575     
Asp Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly Asp Gly
            580                 585                 590         
Leu Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met Gln Ala
        595                 600                 605             
Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln Phe Glu Ser
    610                 615                 620                 
Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val Gly Asp Tyr
625                 630                 635                 640 
Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg Ile Leu Thr
                645                 650                 655     
Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala Pro Lys Gly
            660                 665                 670         
Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu Ser Leu Val
        675                 680                 685             
Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr Ile Arg Ala
    690                 695                 700                 
Arg Lys Pro Ser Lys Gln Ala
705                 710     


<210> 17
<211> 2457
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding 8NS Fusion Polypeptide

<400> 17
atgaaggaca aggcgacggg caagacgcag aacatcacga tcacggcgaa cggcgggctg 60
tcgaaggagc agatcgagca gatgatccgc gactcggagc agcacgcgga ggccgaccgc 120
gtgaagcgcg agcttgtgga ggtgcgcaac aacgcggaga cgcagctgac aacggcggag 180
aggcagctcg gcgagtggaa gtacgtgagc gatgcggaga aggagaacgt gaagacgctg 240
gtggcggagc tgcgcaaggc gatggagaac ccgaacgtcg cgaaggatga ccttgcggct 300
gcgacggaca agctgcagaa ggctgtgatg gagtgcggcc gcacagagta ccagcaggct 360
gccgcggcca actccggcag caccagcaac tccggtgagc agcagcagca gcagggccaa 420
ggtgagcagc agcagcagca gaacagcgaa gagaagaaga tgccgcgcaa gattattctc 480
gattgtgatc ccgggatcga tgatgccgtg gccatctttc tcgcccacgg caacccggag 540
gtcgagctgc tggccattac gacggtggtg ggcaaccaga ccctggagaa ggtgacccgg 600
aacgcgcggc tggtagctga cgtagccggc atcgttggtg tgcccgtcgc ggctggttgc 660
accaagcccc tcgtgcgcgg tgtgcggaat gcctctcaga ttcatggcga aaccggcatg 720
ggtaacgtct cctacccacc agagttcaag acaaagttgg acggccgtca tgcagtgcag 780
ctgatcatcg accttatcat gtcgcacgag ccgaagacga tcacgcttgt gcctacgggt 840
ggcctgacga acattgcgat ggctgtccgt cttgagccgc gcatcgtgga ccgtgtgaag 900
gaggtggttc tgatgggtgg cggctaccat actggtaatg cgtcccctgt agcggagttc 960
aacgtcttcg tcgacccgga ggcggcgcac attgtgttca acgagagctg gaacgtaacg 1020
atggtggggc tggacctaac gcaccaggca ctcgccacgc cggcggtcca gaagcgagtg 1080
aaggaggtgg gcacgaagcc ggctgccttc atgctgcaga ttttggactt ttacacgaag 1140
gtgtacgaaa aggagcgcaa cacgtacgcg acggtgcacg atccctgcgc tgtggcgtac 1200
gtgattgacc ccaccgtgat gacgacggag caagtgccag tggacatcga gctcaatggg 1260
gcactgacga ctgggatgac ggtcgcggac ttccgctacc cacggccaaa gcactgccac 1320
acgcaggtgg ctgtgaagct ggacttcgac aagttttggt gcctcgtgat tgacgcactc 1380
aagcgcatcg gcgatcctca atccgccggt ggccgtgaga ccgcgccgac gaacctgatt 1440
cgtcgccgca acaaggacga gacaaacggg gatgtcagcg ccgccgccga ccgcttccgc 1500
gaccgcttcg agaaggcaac cctcgaggag cgcaaggccg ccaccacgac gatggtcaac 1560
gagtactacg acctggtgac ggacttctac gagtacggct ggggccagaa cttccatttc 1620
gcgccgcgct acgccggcga gaccttcttc gagtccctcg cgcgccacga gtacttcctg 1680
gccgctcgcg gcggcttcat ggagggcgac cacatcgtcg acgtgggctg cggcgtcggc 1740
ggtccggcgc gcaacatggt tcgcctcacg cgctgcaacg tcatcggcgt caacaacaac 1800
gattaccaga tcagccgcgc tcgccgtcat gacgcgctcg ccggtatgag ctccaagatc 1860
gactacgtca agaccgactt ctgcaacatg agcttagccg acaacacctt cgacggcgcc 1920
tacgccatcg aggccacctg ccacgcaaag gacaaggtca agtgctatag cgaggtcttc 1980
cgtgtcatca agcccggcac ctgctttgtc ctgtacgagt ggtgcatgac cgacaagtac 2040
aaccccaatg acgagtacca ccgcacaatc aagcaccgca tcgagctggg cgacggcctg 2100
ccggagatgg agacgtgcaa acaggtgatc gagtacatga agcaggccgg cttcgtggtg 2160
gaggaggcca tagacgtcat cagtcagttc gagtccagcc ccatcaagag tatcccgtgg 2220
taccagccgc tggtcggcga ctattcgtcc ctgcagggcc tgcgctctac cccgattggc 2280
cgcatcctca cgaacgtcat gtgtcgcgtg ctggagttcg tgcgcctagc tccgaagggc 2340
acgtacaagg cgacggagat tttggaggag gctgcggaaa gcctggtggt gggcggtcag 2400
ctcggcatct tcacgccgtc cttctacatc cgcgctcgca agccgtccaa gcaggct    2457

<210> 18
<211> 819
<212> PRT
<213> Artificial Sequence

<220> 
<223> 8NS Fusion Polypeptide

<400> 18
Met Lys Asp Lys Ala Thr Gly Lys Thr Gln Asn Ile Thr Ile Thr Ala
 1               5                  10                  15      
Asn Gly Gly Leu Ser Lys Glu Gln Ile Glu Gln Met Ile Arg Asp Ser
            20                  25                  30          
Glu Gln His Ala Glu Ala Asp Arg Val Lys Arg Glu Leu Val Glu Val
        35                  40                  45              
Arg Asn Asn Ala Glu Thr Gln Leu Thr Thr Ala Glu Arg Gln Leu Gly
    50                  55                  60                  
Glu Trp Lys Tyr Val Ser Asp Ala Glu Lys Glu Asn Val Lys Thr Leu
65                  70                  75                  80  
Val Ala Glu Leu Arg Lys Ala Met Glu Asn Pro Asn Val Ala Lys Asp
                85                  90                  95      
Asp Leu Ala Ala Ala Thr Asp Lys Leu Gln Lys Ala Val Met Glu Cys
            100                 105                 110         
Gly Arg Thr Glu Tyr Gln Gln Ala Ala Ala Ala Asn Ser Gly Ser Thr
        115                 120                 125             
Ser Asn Ser Gly Glu Gln Gln Gln Gln Gln Gly Gln Gly Glu Gln Gln
    130                 135                 140                 
Gln Gln Gln Asn Ser Glu Glu Lys Lys Met Pro Arg Lys Ile Ile Leu
145                 150                 155                 160 
Asp Cys Asp Pro Gly Ile Asp Asp Ala Val Ala Ile Phe Leu Ala His
                165                 170                 175     
Gly Asn Pro Glu Val Glu Leu Leu Ala Ile Thr Thr Val Val Gly Asn
            180                 185                 190         
Gln Thr Leu Glu Lys Val Thr Arg Asn Ala Arg Leu Val Ala Asp Val
        195                 200                 205             
Ala Gly Ile Val Gly Val Pro Val Ala Ala Gly Cys Thr Lys Pro Leu
    210                 215                 220                 
Val Arg Gly Val Arg Asn Ala Ser Gln Ile His Gly Glu Thr Gly Met
225                 230                 235                 240 
Gly Asn Val Ser Tyr Pro Pro Glu Phe Lys Thr Lys Leu Asp Gly Arg
                245                 250                 255     
His Ala Val Gln Leu Ile Ile Asp Leu Ile Met Ser His Glu Pro Lys
            260                 265                 270         
Thr Ile Thr Leu Val Pro Thr Gly Gly Leu Thr Asn Ile Ala Met Ala
        275                 280                 285             
Val Arg Leu Glu Pro Arg Ile Val Asp Arg Val Lys Glu Val Val Leu
    290                 295                 300                 
Met Gly Gly Gly Tyr His Thr Gly Asn Ala Ser Pro Val Ala Glu Phe
305                 310                 315                 320 
Asn Val Phe Val Asp Pro Glu Ala Ala His Ile Val Phe Asn Glu Ser
                325                 330                 335     
Trp Asn Val Thr Met Val Gly Leu Asp Leu Thr His Gln Ala Leu Ala
            340                 345                 350         
Thr Pro Ala Val Gln Lys Arg Val Lys Glu Val Gly Thr Lys Pro Ala
        355                 360                 365             
Ala Phe Met Leu Gln Ile Leu Asp Phe Tyr Thr Lys Val Tyr Glu Lys
    370                 375                 380                 
Glu Arg Asn Thr Tyr Ala Thr Val His Asp Pro Cys Ala Val Ala Tyr
385                 390                 395                 400 
Val Ile Asp Pro Thr Val Met Thr Thr Glu Gln Val Pro Val Asp Ile
                405                 410                 415     
Glu Leu Asn Gly Ala Leu Thr Thr Gly Met Thr Val Ala Asp Phe Arg
            420                 425                 430         
Tyr Pro Arg Pro Lys His Cys His Thr Gln Val Ala Val Lys Leu Asp
        435                 440                 445             
Phe Asp Lys Phe Trp Cys Leu Val Ile Asp Ala Leu Lys Arg Ile Gly
    450                 455                 460                 
Asp Pro Gln Ser Ala Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile
465                 470                 475                 480 
Arg Arg Arg Asn Lys Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala
                485                 490                 495     
Asp Arg Phe Arg Asp Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys
            500                 505                 510         
Ala Ala Thr Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp
        515                 520                 525             
Phe Tyr Glu Tyr Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr
    530                 535                 540                 
Ala Gly Glu Thr Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu
545                 550                 555                 560 
Ala Ala Arg Gly Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly
                565                 570                 575     
Cys Gly Val Gly Gly Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys
            580                 585                 590         
Asn Val Ile Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg
        595                 600                 605             
Arg His Asp Ala Leu Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys
    610                 615                 620                 
Thr Asp Phe Cys Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala
625                 630                 635                 640 
Tyr Ala Ile Glu Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr
                645                 650                 655     
Ser Glu Val Phe Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr
            660                 665                 670         
Glu Trp Cys Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg
        675                 680                 685             
Thr Ile Lys His Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu
    690                 695                 700                 
Thr Cys Lys Gln Val Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val
705                 710                 715                 720 
Glu Glu Ala Ile Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys
                725                 730                 735     
Ser Ile Pro Trp Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln
            740                 745                 750         
Gly Leu Arg Ser Thr Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys
        755                 760                 765             
Arg Val Leu Glu Phe Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala
    770                 775                 780                 
Thr Glu Ile Leu Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln
785                 790                 795                 800 
Leu Gly Ile Phe Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser
                805                 810                 815     
Lys Gln Ala
            


<210> 19
<211> 2571
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding 21NS Fusion Polypeptide

<400> 19
atgagcatta tcaaggagga cgacgccgtg ggctgctaca tgacggtgac cctcgtggac 60
gacaccaagg tggagggtac catcttcacc tacaatccca aggaaggcat catagtactt 120
ctgtccctcc gcgacgatca gacgaacatg aagctgatcc gcactccata catcaaagag 180
ttcagtattt cacacgctga ggagggaacg cacctgcctc cggcactgga ctccttcaac 240
gagcttccgt ccatgcatgc cggccgcgac aagtccatct tcaagcacgc cagcacgcag 300
ctcaagaacg ccgaggcgaa ccgcgaaaag cacttcaact ctgtcacgac cgacacaccg 360
attgccacac tcgatgcgta cctcaagctc ctgcggctat accccttcat tgagtggaac 420
agcgacgagg gtgtcatcca ggtctcggat accgtcattg tcgtagggga ccccgactgg 480
cggacgccca aggcgatgct ggtagacggc gcccctgaga aggacagacc gctcgtagac 540
cgcctgcagg ttgcgctcgg aaacggcaag aagatgccgc gcaagattat tctcgattgt 600
gatcccggga tcgatgatgc cgtggccatc tttctcgccc acggcaaccc ggaggtcgag 660
ctgctggcca ttacgacggt ggtgggcaac cagaccctgg agaaggtgac ccggaacgcg 720
cggctggtag ctgacgtagc cggcatcgtt ggtgtgcccg tcgcggctgg ttgcaccaag 780
cccctcgtgc gcggtgtgcg gaatgcctct cagattcatg gcgaaaccgg catgggtaac 840
gtctcctacc caccagagtt caagacaaag ttggacggcc gtcatgcagt gcagctgatc 900
atcgacctta tcatgtcgca cgagccgaag acgatcacgc ttgtgcctac gggtggcctg 960
acgaacattg cgatggctgt ccgtcttgag ccgcgcatcg tggaccgtgt gaaggaggtg 1020
gttctgatgg gtggcggcta ccatactggt aatgcgtccc ctgtagcgga gttcaacgtc 1080
ttcgtcgacc cggaggcggc gcacattgtg ttcaacgaga gctggaacgt aacgatggtg 1140
gggctggacc taacgcacca ggcactcgcc acgccggcgg tccagaagcg agtgaaggag 1200
gtgggcacga agccggctgc cttcatgctg cagattttgg acttttacac gaaggtgtac 1260
gaaaaggagc gcaacacgta cgcgacggtg cacgatccct gcgctgtggc gtacgtgatt 1320
gaccccaccg tgatgacgac ggagcaagtg ccagtggaca tcgagctcaa tggggcactg 1380
acgactggga tgacggtcgc ggacttccgc tacccacggc caaagcactg ccacacgcag 1440
gtggctgtga agctggactt cgacaagttt tggtgcctcg tgattgacgc actcaagcgc 1500
atcggcgatc ctcaatccgc cggtggccgt gagaccgcgc cgacgaacct gattcgtcgc 1560
cgcaacaagg acgagacaaa cggggatgtc agcgccgccg ccgaccgctt ccgcgaccgc 1620
ttcgagaagg caaccctcga ggagcgcaag gccgccacca cgacgatggt caacgagtac 1680
tacgacctgg tgacggactt ctacgagtac ggctggggcc agaacttcca tttcgcgccg 1740
cgctacgccg gcgagacctt cttcgagtcc ctcgcgcgcc acgagtactt cctggccgct 1800
cgcggcggct tcatggaggg cgaccacatc gtcgacgtgg gctgcggcgt cggcggtccg 1860
gcgcgcaaca tggttcgcct cacgcgctgc aacgtcatcg gcgtcaacaa caacgattac 1920
cagatcagcc gcgctcgccg tcatgacgcg ctcgccggta tgagctccaa gatcgactac 1980
gtcaagaccg acttctgcaa catgagctta gccgacaaca ccttcgacgg cgcctacgcc 2040
atcgaggcca cctgccacgc aaaggacaag gtcaagtgct atagcgaggt cttccgtgtc 2100
atcaagcccg gcacctgctt tgtcctgtac gagtggtgca tgaccgacaa gtacaacccc 2160
aatgacgagt accaccgcac aatcaagcac cgcatcgagc tgggcgacgg cctgccggag 2220
atggagacgt gcaaacaggt gatcgagtac atgaagcagg ccggcttcgt ggtggaggag 2280
gccatagacg tcatcagtca gttcgagtcc agccccatca agagtatccc gtggtaccag 2340
ccgctggtcg gcgactattc gtccctgcag ggcctgcgct ctaccccgat tggccgcatc 2400
ctcacgaacg tcatgtgtcg cgtgctggag ttcgtgcgcc tagctccgaa gggcacgtac 2460
aaggcgacgg agattttgga ggaggctgcg gaaagcctgg tggtgggcgg tcagctcggc 2520
atcttcacgc cgtccttcta catccgcgct cgcaagccgt ccaagcaggc t          2571

<210> 20
<211> 857
<212> PRT
<213> Artificial Sequence

<220> 
<223> 21NS Fusion Polypeptide

<400> 20
Met Ser Ile Ile Lys Glu Asp Asp Ala Val Gly Cys Tyr Met Thr Val
 1               5                  10                  15      
Thr Leu Val Asp Asp Thr Lys Val Glu Gly Thr Ile Phe Thr Tyr Asn
            20                  25                  30          
Pro Lys Glu Gly Ile Ile Val Leu Leu Ser Leu Arg Asp Asp Gln Thr
        35                  40                  45              
Asn Met Lys Leu Ile Arg Thr Pro Tyr Ile Lys Glu Phe Ser Ile Ser
    50                  55                  60                  
His Ala Glu Glu Gly Thr His Leu Pro Pro Ala Leu Asp Ser Phe Asn
65                  70                  75                  80  
Glu Leu Pro Ser Met His Ala Gly Arg Asp Lys Ser Ile Phe Lys His
                85                  90                  95      
Ala Ser Thr Gln Leu Lys Asn Ala Glu Ala Asn Arg Glu Lys His Phe
            100                 105                 110         
Asn Ser Val Thr Thr Asp Thr Pro Ile Ala Thr Leu Asp Ala Tyr Leu
        115                 120                 125             
Lys Leu Leu Arg Leu Tyr Pro Phe Ile Glu Trp Asn Ser Asp Glu Gly
    130                 135                 140                 
Val Ile Gln Val Ser Asp Thr Val Ile Val Val Gly Asp Pro Asp Trp
145                 150                 155                 160 
Arg Thr Pro Lys Ala Met Leu Val Asp Gly Ala Pro Glu Lys Asp Arg
                165                 170                 175     
Pro Leu Val Asp Arg Leu Gln Val Ala Leu Gly Asn Gly Lys Lys Met
            180                 185                 190         
Pro Arg Lys Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala Val
        195                 200                 205             
Ala Ile Phe Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala Ile
    210                 215                 220                 
Thr Thr Val Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn Ala
225                 230                 235                 240 
Arg Leu Val Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala Ala
                245                 250                 255     
Gly Cys Thr Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln Ile
            260                 265                 270         
His Gly Glu Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe Lys
        275                 280                 285             
Thr Lys Leu Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu Ile
    290                 295                 300                 
Met Ser His Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly Leu
305                 310                 315                 320 
Thr Asn Ile Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp Arg
                325                 330                 335     
Val Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn Ala
            340                 345                 350         
Ser Pro Val Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala His
        355                 360                 365             
Ile Val Phe Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp Leu
    370                 375                 380                 
Thr His Gln Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys Glu
385                 390                 395                 400 
Val Gly Thr Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe Tyr
                405                 410                 415     
Thr Lys Val Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His Asp
            420                 425                 430         
Pro Cys Ala Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr Glu
        435                 440                 445             
Gln Val Pro Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly Met
    450                 455                 460                 
Thr Val Ala Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr Gln
465                 470                 475                 480 
Val Ala Val Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile Asp
                485                 490                 495     
Ala Leu Lys Arg Ile Gly Asp Pro Gln Ser Ala Gly Gly Arg Glu Thr
            500                 505                 510         
Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn Gly
        515                 520                 525             
Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys Ala
    530                 535                 540                 
Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu Tyr
545                 550                 555                 560 
Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn Phe
                565                 570                 575     
His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu Ala
            580                 585                 590         
Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly Asp
        595                 600                 605             
His Ile Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn Met
    610                 615                 620                 
Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp Tyr
625                 630                 635                 640 
Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser Ser
                645                 650                 655     
Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala Asp
            660                 665                 670         
Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala Lys
        675                 680                 685             
Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro Gly
    690                 695                 700                 
Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn Pro
705                 710                 715                 720 
Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly Asp
                725                 730                 735     
Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met Lys
            740                 745                 750         
Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln Phe
        755                 760                 765             
Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val Gly
    770                 775                 780                 
Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg Ile
785                 790                 795                 800 
Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala Pro
                805                 810                 815     
Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu Ser
            820                 825                 830         
Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr Ile
        835                 840                 845             
Arg Ala Arg Lys Pro Ser Lys Gln Ala
    850                 855         


<210> 21
<211> 2499
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding 21SC Fusion Polypeptide

<400> 21
atgagcatta tcaaggagga cgacgccgtg ggctgctaca tgacggtgac cctcgtggac 60
gacaccaagg tggagggtac catcttcacc tacaatccca aggaaggcat catagtactt 120
ctgtccctcc gcgacgatca gacgaacatg aagctgatcc gcactccata catcaaagag 180
ttcagtattt cacacgctga ggagggaacg cacctgcctc cggcactgga ctccttcaac 240
gagcttccgt ccatgcatgc cggccgcgac aagtccatct tcaagcacgc cagcacgcag 300
ctcaagaacg ccgaggcgaa ccgcgaaaag cacttcaact ctgtcacgac cgacacaccg 360
attgccacac tcgatgcgta cctcaagctc ctgcggctat accccttcat tgagtggaac 420
agcgacgagg gtgtcatcca ggtctcggat accgtcattg tcgtagggga ccccgactgg 480
cggacgccca aggcgatgct ggtagacggc gcccctgaga aggacagacc gctcgtagac 540
cgcctgcagg ttgcgctcgg aaacggcaag aagtccgccg gtggccgtga gaccgcgccg 600
acgaacctga ttcgtcgccg caacaaggac gagacaaacg gggatgtcag cgccgccgcc 660
gaccgcttcc gcgaccgctt cgagaaggca accctcgagg agcgcaaggc cgccaccacg 720
acgatggtca acgagtacta cgacctggtg acggacttct acgagtacgg ctggggccag 780
aacttccatt tcgcgccgcg ctacgccggc gagaccttct tcgagtccct cgcgcgccac 840
gagtacttcc tggccgctcg cggcggcttc atggagggcg accacatcgt cgacgtgggc 900
tgcggcgtcg gcggtccggc gcgcaacatg gttcgcctca cgcgctgcaa cgtcatcggc 960
gtcaacaaca acgattacca gatcagccgc gctcgccgtc atgacgcgct cgccggtatg 1020
agctccaaga tcgactacgt caagaccgac ttctgcaaca tgagcttagc cgacaacacc 1080
ttcgacggcg cctacgccat cgaggccacc tgccacgcaa aggacaaggt caagtgctat 1140
agcgaggtct tccgtgtcat caagcccggc acctgctttg tcctgtacga gtggtgcatg 1200
accgacaagt acaaccccaa tgacgagtac caccgcacaa tcaagcaccg catcgagctg 1260
ggcgacggcc tgccggagat ggagacgtgc aaacaggtga tcgagtacat gaagcaggcc 1320
ggcttcgtgg tggaggaggc catagacgtc atcagtcagt tcgagtccag ccccatcaag 1380
agtatcccgt ggtaccagcc gctggtcggc gactattcgt ccctgcaggg cctgcgctct 1440
accccgattg gccgcatcct cacgaacgtc atgtgtcgcg tgctggagtt cgtgcgccta 1500
gctccgaagg gcacgtacaa ggcgacggag attttggagg aggctgcgga aagcctggtg 1560
gtgggcggtc agctcggcat cttcacgccg tccttctaca tccgcgctcg caagccgtcc 1620
aagcaggctt cggcggtcgg caacatcgag tcgcagtggg cccgtgccgg ccacggcttg 1680
gtgagcctgt cggagcagca gctggtgagc tgcgatgaca aagacaatgg ctgcaacggc 1740
gggctgatgc tgcaggcgtt cgagtggctg ctgcgacaca tgtacgggat cgtgttcacg 1800
gagaagagct acccctacac gtccggcaac ggtgatgtgg ccgagtgctt gaacagcagt 1860
aaactcgttc ccggcgcgca aatcgacggc tacgtgatga tcccgagcaa cgaaacggtt 1920
atggctgcgt ggcttgcgga gaatggcccc atcgcgattg cggtcgacgc cagctccttc 1980
atgtcttacc agagcggcgt gctgaccagc tgcgctggcg atgcactgaa ccacggcgtg 2040
ctgctcgtcg ggtacaacaa gaccggtggg gttccgtact gggtgatcaa gaactcgtgg 2100
ggtgaggact ggggcgagaa gggctacgtg cgcgtggtca tggggctgaa cgcgtgcctg 2160
ctcagtgaat accccgtgtc cgcgcatgtg ccgcggagtc tcacccctgg cccgggcacg 2220
gagagcgagg agcgcgcccc taaacgggtg acggtggagc agatgatgtg caccgatatg 2280
tactgcaggg aggggtgcaa gaagagtctt ctcaccgcga acgtgtgcta caagaacggg 2340
ggaggcggct cctctatgac gaagtgcggt ccgcagaagg tgctgatgtg ctcgtactcg 2400
aaccctcatt gctttggtcc tgggctgtgc ctcgagactc ctgatggcaa gtgcgcgccg 2460
tacttcttgg gctcgatcat gaacacctgc cagtacacg                        2499

<210> 22
<211> 833
<212> PRT
<213> Artificial Sequence

<220> 
<223> 21SC Fusion Polypeptide

<400> 22
Met Ser Ile Ile Lys Glu Asp Asp Ala Val Gly Cys Tyr Met Thr Val
 1               5                  10                  15      
Thr Leu Val Asp Asp Thr Lys Val Glu Gly Thr Ile Phe Thr Tyr Asn
            20                  25                  30          
Pro Lys Glu Gly Ile Ile Val Leu Leu Ser Leu Arg Asp Asp Gln Thr
        35                  40                  45              
Asn Met Lys Leu Ile Arg Thr Pro Tyr Ile Lys Glu Phe Ser Ile Ser
    50                  55                  60                  
His Ala Glu Glu Gly Thr His Leu Pro Pro Ala Leu Asp Ser Phe Asn
65                  70                  75                  80  
Glu Leu Pro Ser Met His Ala Gly Arg Asp Lys Ser Ile Phe Lys His
                85                  90                  95      
Ala Ser Thr Gln Leu Lys Asn Ala Glu Ala Asn Arg Glu Lys His Phe
            100                 105                 110         
Asn Ser Val Thr Thr Asp Thr Pro Ile Ala Thr Leu Asp Ala Tyr Leu
        115                 120                 125             
Lys Leu Leu Arg Leu Tyr Pro Phe Ile Glu Trp Asn Ser Asp Glu Gly
    130                 135                 140                 
Val Ile Gln Val Ser Asp Thr Val Ile Val Val Gly Asp Pro Asp Trp
145                 150                 155                 160 
Arg Thr Pro Lys Ala Met Leu Val Asp Gly Ala Pro Glu Lys Asp Arg
                165                 170                 175     
Pro Leu Val Asp Arg Leu Gln Val Ala Leu Gly Asn Gly Lys Lys Ser
            180                 185                 190         
Ala Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn
        195                 200                 205             
Lys Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg
    210                 215                 220                 
Asp Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr
225                 230                 235                 240 
Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr
                245                 250                 255     
Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr
            260                 265                 270         
Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly
        275                 280                 285             
Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly Val Gly
    290                 295                 300                 
Gly Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val Ile Gly
305                 310                 315                 320 
Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala
                325                 330                 335     
Leu Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys
            340                 345                 350         
Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu
        355                 360                 365             
Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu Val Phe
    370                 375                 380                 
Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys Met
385                 390                 395                 400 
Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His
                405                 410                 415     
Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys Lys Gln
            420                 425                 430         
Val Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile
        435                 440                 445             
Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp
    450                 455                 460                 
Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser
465                 470                 475                 480 
Thr Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val Leu Glu
                485                 490                 495     
Phe Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu
            500                 505                 510         
Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe
        515                 520                 525             
Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Ser
    530                 535                 540                 
Ala Val Gly Asn Ile Glu Ser Gln Trp Ala Arg Ala Gly His Gly Leu
545                 550                 555                 560 
Val Ser Leu Ser Glu Gln Gln Leu Val Ser Cys Asp Asp Lys Asp Asn
                565                 570                 575     
Gly Cys Asn Gly Gly Leu Met Leu Gln Ala Phe Glu Trp Leu Leu Arg
            580                 585                 590         
His Met Tyr Gly Ile Val Phe Thr Glu Lys Ser Tyr Pro Tyr Thr Ser
        595                 600                 605             
Gly Asn Gly Asp Val Ala Glu Cys Leu Asn Ser Ser Lys Leu Val Pro
    610                 615                 620                 
Gly Ala Gln Ile Asp Gly Tyr Val Met Ile Pro Ser Asn Glu Thr Val
625                 630                 635                 640 
Met Ala Ala Trp Leu Ala Glu Asn Gly Pro Ile Ala Ile Ala Val Asp
                645                 650                 655     
Ala Ser Ser Phe Met Ser Tyr Gln Ser Gly Val Leu Thr Ser Cys Ala
            660                 665                 670         
Gly Asp Ala Leu Asn His Gly Val Leu Leu Val Gly Tyr Asn Lys Thr
        675                 680                 685             
Gly Gly Val Pro Tyr Trp Val Ile Lys Asn Ser Trp Gly Glu Asp Trp
    690                 695                 700                 
Gly Glu Lys Gly Tyr Val Arg Val Val Met Gly Leu Asn Ala Cys Leu
705                 710                 715                 720 
Leu Ser Glu Tyr Pro Val Ser Ala His Val Pro Arg Ser Leu Thr Pro
                725                 730                 735     
Gly Pro Gly Thr Glu Ser Glu Glu Arg Ala Pro Lys Arg Val Thr Val
            740                 745                 750         
Glu Gln Met Met Cys Thr Asp Met Tyr Cys Arg Glu Gly Cys Lys Lys
        755                 760                 765             
Ser Leu Leu Thr Ala Asn Val Cys Tyr Lys Asn Gly Gly Gly Gly Ser
    770                 775                 780                 
Ser Met Thr Lys Cys Gly Pro Gln Lys Val Leu Met Cys Ser Tyr Ser
785                 790                 795                 800 
Asn Pro His Cys Phe Gly Pro Gly Leu Cys Leu Glu Thr Pro Asp Gly
                805                 810                 815     
Lys Cys Ala Pro Tyr Phe Leu Gly Ser Ile Met Asn Thr Cys Gln Tyr
            820                 825                 830         
Thr
    


<210> 23
<211> 2091
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding 821S Fusion Polypeptide

<400> 23
atgaaggaca aggcgacggg caagacgcag aacatcacga tcacggcgaa cggcgggctg 60
tcgaaggagc agatcgagca gatgatccgc gactcggagc agcacgcgga ggccgaccgc 120
gtgaagcgcg agcttgtgga ggtgcgcaac aacgcggaga cgcagctgac aacggcggag 180
aggcagctcg gcgagtggaa gtacgtgagc gatgcggaga aggagaacgt gaagacgctg 240
gtggcggagc tgcgcaaggc gatggagaac ccgaacgtcg cgaaggatga ccttgcggct 300
gcgacggaca agctgcagaa ggctgtgatg gagtgcggcc gcacagagta ccagcaggct 360
gccgcggcca actccggcag caccagcaac tccggtgagc agcagcagca gcagggccaa 420
ggtgagcagc agcagcagca gaacagcgaa gagaagaaga tgagcattat caaggaggac 480
gacgccgtgg gctgctacat gacggtgacc ctcgtggacg acaccaaggt ggagggtacc 540
atcttcacct acaatcccaa ggaaggcatc atagtacttc tgtccctccg cgacgatcag 600
acgaacatga agctgatccg cactccatac atcaaagagt tcagtatttc acacgctgag 660
gagggaacgc acctgcctcc ggcactggac tccttcaacg agcttccgtc catgcatgcc 720
ggccgcgaca agtccatctt caagcacgcc agcacgcagc tcaagaacgc cgaggcgaac 780
cgcgaaaagc acttcaactc tgtcacgacc gacacaccga ttgccacact cgatgcgtac 840
ctcaagctcc tgcggctata ccccttcatt gagtggaaca gcgacgaggg tgtcatccag 900
gtctcggata ccgtcattgt cgtaggggac cccgactggc ggacgcccaa ggcgatgctg 960
gtagacggcg cccctgagaa ggacagaccg ctcgtagacc gcctgcaggt tgcgctcgga 1020
aacggcaaga agatgtccgc cggtggccgt gagaccgcgc cgacgaacct gattcgtcgc 1080
cgcaacaagg acgagacaaa cggggatgtc agcgccgccg ccgaccgctt ccgcgaccgc 1140
ttcgagaagg caaccctcga ggagcgcaag gccgccacca cgacgatggt caacgagtac 1200
tacgacctgg tgacggactt ctacgagtac ggctggggcc agaacttcca tttcgcgccg 1260
cgctacgccg gcgagacctt cttcgagtcc ctcgcgcgcc acgagtactt cctggccgct 1320
cgcggcggct tcatggaggg cgaccacatc gtcgacgtgg gctgcggcgt cggcggtccg 1380
gcgcgcaaca tggttcgcct cacgcgctgc aacgtcatcg gcgtcaacaa caacgattac 1440
cagatcagcc gcgctcgccg tcatgacgcg ctcgccggta tgagctccaa gatcgactac 1500
gtcaagaccg acttctgcaa catgagctta gccgacaaca ccttcgacgg cgcctacgcc 1560
atcgaggcca cctgccacgc aaaggacaag gtcaagtgct atagcgaggt cttccgtgtc 1620
atcaagcccg gcacctgctt tgtcctgtac gagtggtgca tgaccgacaa gtacaacccc 1680
aatgacgagt accaccgcac aatcaagcac cgcatcgagc tgggcgacgg cctgccggag 1740
atggagacgt gcaaacaggt gatcgagtac atgaagcagg ccggcttcgt ggtggaggag 1800
gccatagacg tcatcagtca gttcgagtcc agccccatca agagtatccc gtggtaccag 1860
ccgctggtcg gcgactattc gtccctgcag ggcctgcgct ctaccccgat tggccgcatc 1920
ctcacgaacg tcatgtgtcg cgtgctggag ttcgtgcgcc tagctccgaa gggcacgtac 1980
aaggcgacgg agattttgga ggaggctgcg gaaagcctgg tggtgggcgg tcagctcggc 2040
atcttcacgc cgtccttcta catccgcgct cgcaagccgt ccaagcaggc t          2091

<210> 24
<211> 697
<212> PRT
<213> Artificial Sequence

<220> 
<223> 821S Fusion Polypeptide

<400> 24
Met Lys Asp Lys Ala Thr Gly Lys Thr Gln Asn Ile Thr Ile Thr Ala
 1               5                  10                  15      
Asn Gly Gly Leu Ser Lys Glu Gln Ile Glu Gln Met Ile Arg Asp Ser
            20                  25                  30          
Glu Gln His Ala Glu Ala Asp Arg Val Lys Arg Glu Leu Val Glu Val
        35                  40                  45              
Arg Asn Asn Ala Glu Thr Gln Leu Thr Thr Ala Glu Arg Gln Leu Gly
    50                  55                  60                  
Glu Trp Lys Tyr Val Ser Asp Ala Glu Lys Glu Asn Val Lys Thr Leu
65                  70                  75                  80  
Val Ala Glu Leu Arg Lys Ala Met Glu Asn Pro Asn Val Ala Lys Asp
                85                  90                  95      
Asp Leu Ala Ala Ala Thr Asp Lys Leu Gln Lys Ala Val Met Glu Cys
            100                 105                 110         
Gly Arg Thr Glu Tyr Gln Gln Ala Ala Ala Ala Asn Ser Gly Ser Thr
        115                 120                 125             
Ser Asn Ser Gly Glu Gln Gln Gln Gln Gln Gly Gln Gly Glu Gln Gln
    130                 135                 140                 
Gln Gln Gln Asn Ser Glu Glu Lys Lys Met Ser Ile Ile Lys Glu Asp
145                 150                 155                 160 
Asp Ala Val Gly Cys Tyr Met Thr Val Thr Leu Val Asp Asp Thr Lys
                165                 170                 175     
Val Glu Gly Thr Ile Phe Thr Tyr Asn Pro Lys Glu Gly Ile Ile Val
            180                 185                 190         
Leu Leu Ser Leu Arg Asp Asp Gln Thr Asn Met Lys Leu Ile Arg Thr
        195                 200                 205             
Pro Tyr Ile Lys Glu Phe Ser Ile Ser His Ala Glu Glu Gly Thr His
    210                 215                 220                 
Leu Pro Pro Ala Leu Asp Ser Phe Asn Glu Leu Pro Ser Met His Ala
225                 230                 235                 240 
Gly Arg Asp Lys Ser Ile Phe Lys His Ala Ser Thr Gln Leu Lys Asn
                245                 250                 255     
Ala Glu Ala Asn Arg Glu Lys His Phe Asn Ser Val Thr Thr Asp Thr
            260                 265                 270         
Pro Ile Ala Thr Leu Asp Ala Tyr Leu Lys Leu Leu Arg Leu Tyr Pro
        275                 280                 285             
Phe Ile Glu Trp Asn Ser Asp Glu Gly Val Ile Gln Val Ser Asp Thr
    290                 295                 300                 
Val Ile Val Val Gly Asp Pro Asp Trp Arg Thr Pro Lys Ala Met Leu
305                 310                 315                 320 
Val Asp Gly Ala Pro Glu Lys Asp Arg Pro Leu Val Asp Arg Leu Gln
                325                 330                 335     
Val Ala Leu Gly Asn Gly Lys Lys Met Ser Ala Gly Gly Arg Glu Thr
            340                 345                 350         
Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn Gly
        355                 360                 365             
Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys Ala
    370                 375                 380                 
Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu Tyr
385                 390                 395                 400 
Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn Phe
                405                 410                 415     
His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu Ala
            420                 425                 430         
Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly Asp
        435                 440                 445             
His Ile Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn Met
    450                 455                 460                 
Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp Tyr
465                 470                 475                 480 
Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser Ser
                485                 490                 495     
Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala Asp
            500                 505                 510         
Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala Lys
        515                 520                 525             
Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro Gly
    530                 535                 540                 
Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn Pro
545                 550                 555                 560 
Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly Asp
                565                 570                 575     
Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met Lys
            580                 585                 590         
Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln Phe
        595                 600                 605             
Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val Gly
    610                 615                 620                 
Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg Ile
625                 630                 635                 640 
Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala Pro
                645                 650                 655     
Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu Ser
            660                 665                 670         
Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr Ile
        675                 680                 685             
Arg Ala Arg Lys Pro Ser Lys Gln Ala
    690                 695         


<210> 25
<211> 1653
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding 8HS Fusion Polypeptide

<400> 25
atgaaggaca aggcgacggg caagacgcag aacatcacga tcacggcgaa cggcgggctg 60
tcgaaggagc agatcgagca gatgatccgc gactcggagc agcacgcgga ggccgaccgc 120
gtgaagcgcg agcttgtgga ggtgcgcaac aacgcggaga cgcagctgac aacggcggag 180
aggcagctcg gcgagtggaa gtacgtgagc gatgcggaga aggagaacgt gaagacgctg 240
gtggcggagc tgcgcaaggc gatggagaac ccgaacgtcg cgaaggatga ccttgcggct 300
gcgacggaca agctgcagaa ggctgtgatg gagtgcggcc gcacagagta ccagcaggct 360
gccgcggcca actccggcag caccagcaac tccggtgagc agcagcagca gcagggccaa 420
ggtgagcagc agcagcagca gaacagcgaa gagaagaaga tggcctcttc tcgctctgct 480
ccccgcaagg cttcccacgc gcacaagtcg caccgcaagc cgaagcgctc gtggaacgtg 540
tacgtgggcc gctcgctgaa ggcgatcaac gcccagatgt cgatgtcgca ccgcacgtcc 600
gccggtggcc gtgagaccgc gccgacgaac ctgattcgtc gccgcaacaa ggacgagaca 660
aacggggatg tcagcgccgc cgccgaccgc ttccgcgacc gcttcgagaa ggcaaccctc 720
gaggagcgca aggccgccac cacgacgatg gtcaacgagt actacgacct ggtgacggac 780
ttctacgagt acggctgggg ccagaacttc catttcgcgc cgcgctacgc cggcgagacc 840
ttcttcgagt ccctcgcgcg ccacgagtac ttcctggccg ctcgcggcgg cttcatggag 900
ggcgaccaca tcgtcgacgt gggctgcggc gtcggcggtc cggcgcgcaa catggttcgc 960
ctcacgcgct gcaacgtcat cggcgtcaac aacaacgatt accagatcag ccgcgctcgc 1020
cgtcatgacg cgctcgccgg tatgagctcc aagatcgact acgtcaagac cgacttctgc 1080
aacatgagct tagccgacaa caccttcgac ggcgcctacg ccatcgaggc cacctgccac 1140
gcaaaggaca aggtcaagtg ctatagcgag gtcttccgtg tcatcaagcc cggcacctgc 1200
tttgtcctgt acgagtggtg catgaccgac aagtacaacc ccaatgacga gtaccaccgc 1260
acaatcaagc accgcatcga gctgggcgac ggcctgccgg agatggagac gtgcaaacag 1320
gtgatcgagt acatgaagca ggccggcttc gtggtggagg aggccataga cgtcatcagt 1380
cagttcgagt ccagccccat caagagtatc ccgtggtacc agccgctggt cggcgactat 1440
tcgtccctgc agggcctgcg ctctaccccg attggccgca tcctcacgaa cgtcatgtgt 1500
cgcgtgctgg agttcgtgcg cctagctccg aagggcacgt acaaggcgac ggagattttg 1560
gaggaggctg cggaaagcct ggtggtgggc ggtcagctcg gcatcttcac gccgtccttc 1620
tacatccgcg ctcgcaagcc gtccaagcag gct                              1653

<210> 26
<211> 550
<212> PRT
<213> Artificial Sequence

<220> 
<223> 8HS Fusion Polypeptide

<400> 26
Met Lys Asp Lys Ala Thr Gly Lys Thr Gln Asn Ile Thr Ile Thr Ala
 1               5                  10                  15      
Asn Gly Gly Leu Ser Lys Glu Gln Ile Glu Gln Met Ile Arg Asp Ser
            20                  25                  30          
Glu Gln His Ala Glu Ala Asp Arg Val Lys Arg Glu Leu Val Glu Val
        35                  40                  45              
Arg Asn Asn Ala Glu Thr Gln Leu Thr Thr Ala Glu Arg Gln Leu Gly
    50                  55                  60                  
Glu Trp Lys Tyr Val Ser Asp Ala Glu Lys Glu Asn Val Lys Thr Leu
65                  70                  75                  80  
Val Ala Glu Leu Arg Lys Ala Met Glu Asn Pro Asn Val Ala Lys Asp
                85                  90                  95      
Asp Leu Ala Ala Ala Thr Asp Lys Leu Gln Lys Ala Val Met Glu Cys
            100                 105                 110         
Gly Arg Thr Glu Tyr Gln Gln Ala Ala Ala Ala Asn Ser Gly Ser Thr
        115                 120                 125             
Ser Asn Ser Gly Glu Gln Gln Gln Gln Gln Gly Gln Gly Glu Gln Gln
    130                 135                 140                 
Gln Gln Gln Asn Ser Glu Glu Lys Lys Met Ala Ser Ser Arg Ser Ala
145                 150                 155                 160 
Pro Arg Lys Ala Ser His Ala His Lys Ser His Arg Lys Pro Lys Arg
                165                 170                 175     
Ser Trp Asn Val Tyr Val Gly Arg Ser Leu Lys Ala Ile Asn Ala Gln
            180                 185                 190         
Met Ser Met Ser His Arg Thr Ser Ala Gly Gly Arg Glu Thr Ala Pro
        195                 200                 205             
Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn Gly Asp Val
    210                 215                 220                 
Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys Ala Thr Leu
225                 230                 235                 240 
Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu Tyr Tyr Asp
                245                 250                 255     
Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn Phe His Phe
            260                 265                 270         
Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu Ala Arg His
        275                 280                 285             
Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly Asp His Ile
    290                 295                 300                 
Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn Met Val Arg
305                 310                 315                 320 
Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp Tyr Gln Ile
                325                 330                 335     
Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser Ser Lys Ile
            340                 345                 350         
Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala Asp Asn Thr
        355                 360                 365             
Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala Lys Asp Lys
    370                 375                 380                 
Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro Gly Thr Cys
385                 390                 395                 400 
Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn Pro Asn Asp
                405                 410                 415     
Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly Asp Gly Leu
            420                 425                 430         
Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met Lys Gln Ala
        435                 440                 445             
Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln Phe Glu Ser
    450                 455                 460                 
Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val Gly Asp Tyr
465                 470                 475                 480 
Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg Ile Leu Thr
                485                 490                 495     
Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala Pro Lys Gly
            500                 505                 510         
Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu Ser Leu Val
        515                 520                 525             
Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr Ile Arg Ala
    530                 535                 540                 
Arg Lys Pro Ser Lys Gln
545                 550 


<210> 27
<211> 152
<212> PRT
<213> Unknown

<220> 
<223> 8E Polypeptide from Leishmania infantum or
      donovani

<400> 27
Lys Asp Lys Ala Thr Gly Lys Thr Gln Asn Ile Thr Ile Thr Ala Asn
 1               5                  10                  15      
Gly Gly Leu Ser Lys Glu Gln Ile Glu Gln Met Ile Arg Asp Ser Glu
            20                  25                  30          
Gln His Ala Glu Ala Asp Arg Val Lys Arg Glu Leu Val Glu Val Arg
        35                  40                  45              
Asn Asn Ala Glu Thr Gln Leu Thr Thr Ala Glu Arg Gln Leu Gly Glu
    50                  55                  60                  
Trp Lys Tyr Val Ser Asp Ala Glu Lys Glu Asn Val Lys Thr Leu Val
65                  70                  75                  80  
Ala Glu Leu Arg Lys Ala Met Glu Asn Pro Asn Val Ala Lys Asp Asp
                85                  90                  95      
Leu Ala Ala Ala Thr Asp Lys Leu Gln Lys Ala Val Met Glu Cys Gly
            100                 105                 110         
Arg Thr Glu Tyr Gln Gln Ala Ala Ala Ala Asn Ser Gly Ser Thr Ser
        115                 120                 125             
Asn Ser Gly Glu Gln Gln Gln Gln Gln Gly Gln Gly Glu Gln Gln Gln
    130                 135                 140                 
Gln Gln Asn Ser Glu Glu Lys Lys
145                 150         


<210> 28
<211> 152
<212> PRT
<213> Leishmania major

<400> 28
Lys Asp Lys Ala Thr Gly Lys Thr Gln Asn Ile Thr Ile Thr Ala Asn
 1               5                  10                  15      
Gly Gly Leu Ser Lys Glu Gln Ile Glu Gln Met Ile Arg Asp Ser Glu
            20                  25                  30          
Gln His Ala Glu Ala Asp Arg Val Lys Arg Glu Leu Val Glu Val Arg
        35                  40                  45              
Asn Asn Ala Glu Thr Gln Leu Thr Thr Ala Glu Arg Gln Leu Gly Glu
    50                  55                  60                  
Trp Lys Tyr Val Ser Asp Ala Glu Lys Glu Asn Val Lys Thr Leu Val
65                  70                  75                  80  
Ala Glu Leu Arg Lys Ala Met Glu Asn Pro Asn Val Ala Lys Asp Asp
                85                  90                  95      
Leu Ala Ala Ala Thr Asp Lys Leu Gln Lys Ala Val Met Glu Cys Gly
            100                 105                 110         
Arg Thr Glu Tyr Gln Gln Ala Ala Ala Ala Asn Ser Gly Ser Thr Ser
        115                 120                 125             
Asn Ser Gly Glu Gln Gln Gln Gln Gln Ser Gln Gly Glu Gln Gln Gln
    130                 135                 140                 
Gln Gln Asn Ser Glu Glu Lys Lys
145                 150         


<210> 29
<211> 157
<212> PRT
<213> Leishmania mexicana

<400> 29
Lys Asp Lys Ala Thr Gly Lys Thr Gln Asn Ile Thr Ile Thr Ala Asn
 1               5                  10                  15      
Gly Gly Leu Ser Lys Glu Gln Ile Glu Gln Met Ile Arg Asp Ser Glu
            20                  25                  30          
Gln His Ala Glu Ala Asp Arg Val Lys Arg Glu Leu Val Glu Val Arg
        35                  40                  45              
Asn Asn Ala Glu Thr Gln Leu Thr Thr Ala Glu Arg Gln Leu Ser Glu
    50                  55                  60                  
Trp Lys Tyr Val Ser Asp Ala Glu Lys Glu Asn Val Arg Thr Leu Val
65                  70                  75                  80  
Ala Glu Leu Arg Lys Ala Met Glu Asn Pro Asn Val Ala Lys Asp Asp
                85                  90                  95      
Leu Ser Ala Ala Thr Asp Lys Leu Gln Lys Ala Val Met Glu Cys Gly
            100                 105                 110         
Arg Thr Glu Tyr Gln Gln Ala Ala Ala Ala Asn Ser Gly Ser Thr Ser
        115                 120                 125             
Asn Ser Gly Glu Gln Gln Gln Gln Gln Gln Gln Ser Gln Gly Glu Gln
    130                 135                 140                 
Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Glu Glu Arg
145                 150                 155         


<210> 30
<211> 152
<212> PRT
<213> Leishmania braziliensis

<400> 30
Lys Asp Lys Ala Thr Gly Lys Thr Gln Asn Ile Thr Ile Thr Ala His
 1               5                  10                  15      
Gly Gly Leu Ser Lys Glu Gln Ile Glu Gln Met Val Arg Asp Ser Glu
            20                  25                  30          
Gln His Ala Glu Ala Asp Arg Val Lys Arg Glu Leu Val Glu Ala Arg
        35                  40                  45              
Asn Asn Ala Glu Thr Gln Leu Thr Thr Ala Glu Arg Gln Leu Gly Glu
    50                  55                  60                  
Trp Lys Tyr Val Ser Asp Ala Glu Lys Glu Asn Val Lys Thr His Val
65                  70                  75                  80  
Ala Glu Leu Arg Lys Ala Met Glu Asn Pro Asn Val Ala Lys Asp Asp
                85                  90                  95      
Leu Ala Ala Ala Thr Asp Lys Leu Gln Lys Ala Val Met Glu Cys Gly
            100                 105                 110         
Arg Thr Glu Tyr Gln Gln Ala Ala Ala Ala Asn Ser Gly Ser Ser Ser
        115                 120                 125             
Asn Ser Gly Glu Gln Gln Gln Gln Gln Gln Gln Gln Gly Asp Gln Gln
    130                 135                 140                 
Gln Gln Gln Ser Ser Glu Lys Asn
145                 150         


<210> 31
<211> 290
<212> PRT
<213> Leishmania infantum

<400> 31
Ser Ala Val Gly Asn Ile Glu Ser Gln Trp Ala Arg Ala Gly His Gly
 1               5                  10                  15      
Leu Val Ser Leu Ser Glu Gln Gln Leu Val Ser Cys Asp Asp Lys Asp
            20                  25                  30          
Asn Gly Cys Asn Gly Gly Leu Met Leu Gln Ala Phe Glu Trp Leu Leu
        35                  40                  45              
Arg His Met Tyr Gly Ile Val Phe Thr Glu Lys Ser Tyr Pro Tyr Thr
    50                  55                  60                  
Ser Gly Asn Gly Asp Val Ala Glu Cys Leu Asn Ser Ser Lys Leu Val
65                  70                  75                  80  
Pro Gly Ala Gln Ile Asp Gly Tyr Val Met Ile Pro Ser Asn Glu Thr
                85                  90                  95      
Val Met Ala Ala Trp Leu Ala Glu Asn Gly Pro Ile Ala Ile Ala Val
            100                 105                 110         
Asp Ala Ser Ser Phe Met Ser Tyr Gln Ser Gly Val Leu Thr Ser Cys
        115                 120                 125             
Ala Gly Asp Ala Leu Asn His Gly Val Leu Leu Val Gly Tyr Asn Lys
    130                 135                 140                 
Thr Gly Gly Val Pro Tyr Trp Val Ile Lys Asn Ser Trp Gly Glu Asp
145                 150                 155                 160 
Trp Gly Glu Lys Gly Tyr Val Arg Val Val Met Gly Leu Asn Ala Cys
                165                 170                 175     
Leu Leu Ser Glu Tyr Pro Val Ser Ala His Val Pro Arg Ser Leu Thr
            180                 185                 190         
Pro Gly Pro Gly Thr Glu Ser Glu Glu Arg Ala Pro Lys Arg Val Thr
        195                 200                 205             
Val Glu Gln Met Met Cys Thr Asp Met Tyr Cys Arg Glu Gly Cys Lys
    210                 215                 220                 
Lys Ser Leu Leu Thr Ala Asn Val Cys Tyr Lys Asn Gly Gly Gly Gly
225                 230                 235                 240 
Ser Ser Met Thr Lys Cys Gly Pro Gln Lys Val Leu Met Cys Ser Tyr
                245                 250                 255     
Ser Asn Pro His Cys Phe Gly Pro Gly Leu Cys Leu Glu Thr Pro Asp
            260                 265                 270         
Gly Lys Cys Ala Pro Tyr Phe Leu Gly Ser Ile Met Asn Thr Cys Gln
        275                 280                 285             
Tyr Thr
    290 


<210> 32
<211> 46
<212> PRT
<213> Leishmania infantum

<400> 32
Met Ala Ser Ser Arg Ser Ala Pro Arg Lys Ala Ser His Ala His Lys
 1               5                  10                  15      
Ser His Arg Lys Pro Lys Arg Ser Trp Asn Val Tyr Val Gly Arg Ser
            20                  25                  30          
Leu Lys Ala Ile Asn Ala Gln Met Ser Met Ser His Arg Thr
        35                  40                  45      


<210> 33
<211> 214
<212> PRT
<213> Leishmania donovani

<400> 33
Ser Ala Ser Ala Glu Pro His Lys Ala Ala Val Asp Val Gly Pro Leu
 1               5                  10                  15      
Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala
            20                  25                  30          
Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val
        35                  40                  45              
Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly
    50                  55                  60                  
Pro Leu Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
65                  70                  75                  80  
Leu Ser Val Gly Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
                85                  90                  95      
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser
            100                 105                 110         
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val
        115                 120                 125             
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
    130                 135                 140                 
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro
145                 150                 155                 160 
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
                165                 170                 175     
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser
            180                 185                 190         
Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
        195                 200                 205             
Asp Val Ser Pro Val Ser
    210                 


<210> 34
<211> 190
<212> PRT
<213> Leishmania infantum

<400> 34
Ser Ile Ile Lys Glu Asp Asp Ala Val Gly Cys Tyr Met Thr Val Thr
 1               5                  10                  15      
Leu Val Asp Asp Thr Lys Val Glu Gly Thr Ile Phe Thr Tyr Asn Pro
            20                  25                  30          
Lys Glu Gly Ile Ile Val Leu Leu Ser Leu Arg Asp Asp Gln Thr Asn
        35                  40                  45              
Met Lys Leu Ile Arg Thr Pro Tyr Ile Lys Glu Phe Ser Ile Ser His
    50                  55                  60                  
Ala Glu Glu Gly Thr His Leu Pro Pro Ala Leu Asp Ser Phe Asn Glu
65                  70                  75                  80  
Leu Pro Ser Met His Ala Gly Arg Asp Lys Ser Ile Phe Lys His Ala
                85                  90                  95      
Ser Thr Gln Leu Lys Asn Ala Glu Ala Asn Arg Glu Lys His Phe Asn
            100                 105                 110         
Ser Val Thr Thr Asp Thr Pro Ile Ala Thr Leu Asp Ala Tyr Leu Lys
        115                 120                 125             
Leu Leu Arg Leu Tyr Pro Phe Ile Glu Trp Asn Ser Asp Glu Gly Val
    130                 135                 140                 
Ile Gln Val Ser Asp Thr Val Ile Val Val Gly Asp Pro Asp Trp Arg
145                 150                 155                 160 
Thr Pro Lys Ala Met Leu Val Asp Gly Ala Pro Glu Lys Asp Arg Pro
                165                 170                 175     
Leu Val Asp Arg Leu Gln Val Ala Leu Gly Asn Gly Lys Lys
            180                 185                 190 


<210> 35
<211> 314
<212> PRT
<213> Unknown

<220> 
<223> Full length nonspecific nucleoside hydrolase
      polypeptide (NH) from Leishmania infantum or
      donovani

<400> 35
Met Pro Arg Lys Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala
 1               5                  10                  15      
Val Ala Ile Phe Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala
            20                  25                  30          
Ile Thr Thr Val Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn
        35                  40                  45              
Ala Arg Leu Val Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala
    50                  55                  60                  
Ala Gly Cys Thr Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln
65                  70                  75                  80  
Ile His Gly Glu Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe
                85                  90                  95      
Lys Thr Lys Leu Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu
            100                 105                 110         
Ile Met Ser His Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly
        115                 120                 125             
Leu Thr Asn Ile Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp
    130                 135                 140                 
Arg Val Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn
145                 150                 155                 160 
Ala Ser Pro Val Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala
                165                 170                 175     
His Ile Val Phe Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp
            180                 185                 190         
Leu Thr His Gln Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys
        195                 200                 205             
Glu Val Gly Thr Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe
    210                 215                 220                 
Tyr Thr Lys Val Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His
225                 230                 235                 240 
Asp Pro Cys Ala Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr
                245                 250                 255     
Glu Gln Val Pro Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly
            260                 265                 270         
Met Thr Val Ala Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr
        275                 280                 285             
Gln Val Ala Val Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile
    290                 295                 300                 
Asp Ala Leu Lys Arg Ile Gly Asp Pro Gln
305                 310                 


<210> 36
<211> 352
<212> PRT
<213> Leishmania infantum

<400> 36
Ser Ala Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg
 1               5                  10                  15      
Asn Lys Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe
            20                  25                  30          
Arg Asp Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr
        35                  40                  45              
Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu
    50                  55                  60                  
Tyr Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu
65                  70                  75                  80  
Thr Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg
                85                  90                  95      
Gly Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly Val
            100                 105                 110         
Gly Gly Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val Ile
        115                 120                 125             
Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp
    130                 135                 140                 
Ala Leu Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe
145                 150                 155                 160 
Cys Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile
                165                 170                 175     
Glu Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu Val
            180                 185                 190         
Phe Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys
        195                 200                 205             
Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys
    210                 215                 220                 
His Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys Lys
225                 230                 235                 240 
Gln Val Ile Glu Tyr Met Lys Gln Ala Gly Phe Val Val Glu Glu Ala
                245                 250                 255     
Ile Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro
            260                 265                 270         
Trp Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg
        275                 280                 285             
Ser Thr Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val Leu
    290                 295                 300                 
Glu Phe Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile
305                 310                 315                 320 
Leu Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile
                325                 330                 335     
Phe Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala
            340                 345                 350         


<210> 37
<211> 236
<212> PRT
<213> Leishmania donovani

<400> 37
Met Lys Ile Arg Ser Val Arg Pro Leu Val Val Leu Leu Val Ser Val
 1               5                  10                  15      
Ala Ala Val Leu Ala Leu Ser Ala Ser Ala Glu Pro His Lys Ala Ala
            20                  25                  30          
Val Asp Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu
        35                  40                  45              
Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser
    50                  55                  60                  
Val Gly Pro Leu Ser Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val
65                  70                  75                  80  
Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Leu Ser Val Gly
                85                  90                  95      
Pro Gln Ser Val Gly Pro Leu Ser Val Gly Ser Gln Ser Val Gly Pro
            100                 105                 110         
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
        115                 120                 125             
Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser
    130                 135                 140                 
Val Gly Pro Gln Ala Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val
145                 150                 155                 160 
Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly
                165                 170                 175     
Ser Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro
            180                 185                 190         
Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser Val Gly Pro Gln
        195                 200                 205             
Ser Val Gly Pro Leu Ser Val Gly Pro Gln Ser Val Gly Pro Leu Ser
    210                 215                 220                 
Val Gly Pro Gln Ser Val Asp Val Ser Pro Val Ser
225                 230                 235     


<210> 38
<211> 2591
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding 8HNS Fusion Polypeptide

<400> 38
atgaaggaca aggcgacggg caagacgcag aacatcacga tcacggcgaa cggcgggctg 60
tcgaaggagc agatcgagca gatgatccgc gactcggagc agcacgcgga ggccgaccgc 120
gtgaagcgcg agcttgtgga ggtgcgcaac aacgcggaga cgcagctgac aacggcggag 180
aggcagctcg gcgagtggaa gtacgtgagc gatgcggaga aggagaacgt gaagacgctg 240
gtggcggagc tgcgcaaggc gatggagaac ccgaacgtcg cgaaggatga ccttgcggct 300
gcgacggaca agctgcagaa ggctgtgatg gagtgcggcc gcacagagta ccagcaggct 360
gccgcggcca actccggcag caccagcaac tccggtgagc agcagcagca gcagggccaa 420
ggtgagcagc agcagcagca gaacagcgaa gagaagaagc ctcttctcgc tctgctcccc 480
gcaaggcttc ccacgcgcac aagtcgcacc gcaagccgaa gcgctcgtgg aacgtgtacg 540
tgggccgctc gctgaaggcg atcaacgccc agatgtcgat gtcgcaccgc acgatgccgc 600
gcaagattat tctcgattgt gatcccggga tcgatgatgc cgtggccatc tttctcgccc 660
acggcaaccc ggaggtcgag ctgctggcca ttacgacggt ggtgggcaac cagaccctgg 720
agaaggtgac ccggaacgcg cggctggtag ctgacgtagc cggcatcgtt ggtgtgcccg 780
tcgcggctgg ttgcaccaag cccctcgtgc gcggtgtgcg gaatgcctct cagattcatg 840
gcgaaaccgg catgggtaac gtctcctacc caccagagtt caagacaaag ttggacggcc 900
gtcatgcagt gcagctgatc atcgacctta tcatgtcgca cgagccgaag acgatcacgc 960
ttgtgcctac gggtggcctg acgaacattg cgatggctgt ccgtcttgag ccgcgcatcg 1020
tggaccgtgt gaaggaggtg gttctgatgg gtggcggcta ccatactggt aatgcgtccc 1080
ctgtagcgga gttcaacgtc ttcgtcgacc cggaggcggc gcacattgtg ttcaacgaga 1140
gctggaacgt aacgatggtg gggctggacc taacgcacca ggcactcgcc acgccggcgg 1200
tccagaagcg agtgaaggag gtgggcacga agccggctgc cttcatgctg cagattttgg 1260
acttttacac gaaggtgtac gaaaaggagc gcaacacgta cgcgacggtg cacgatccct 1320
gcgctgtggc gtacgtgatt gaccccaccg tgatgacgac ggagcaagtg ccagtggaca 1380
tcgagctcaa tggggcactg acgactggga tgacggtcgc ggacttccgc tacccacggc 1440
caaagcactg ccacacgcag gtggctgtga agctggactt cgacaagttt tggtgcctcg 1500
tgattgacgc actcaagcgc atcggcgatc ctcaatccgc cggtggccgt gagaccgcgc 1560
cgacgaacct gattcgtcgc cgcaacaagg acgagacaaa cggggatgtc agcgccgccg 1620
ccgaccgctt ccgcgaccgc ttcgagaagg caaccctcga ggagcgcaag gccgccacca 1680
cgacgatggt caacgagtac tacgacctgg tgacggactt ctacgagtac ggctggggcc 1740
agaacttcca tttcgcgccg cgctacgccg gcgagacctt cttcgagtcc ctcgcgcgcc 1800
acgagtactt cctggccgct cgcggcggct tcatggaggg cgaccacatc gtcgacgtgg 1860
gctgcggcgt cggcggtccg gcgcgcaaca tggttcgcct cacgcgctgc aacgtcatcg 1920
gcgtcaacaa caacgattac cagatcagcc gcgctcgccg tcatgacgcg ctcgccggta 1980
tgagctccaa gatcgactac gtcaagaccg acttctgcaa catgagctta gccgacaaca 2040
ccttcgacgg cgcctacgcc atcgaggcca cctgccacgc aaaggacaag gtcaagtgct 2100
atagcgaggt cttccgtgtc atcaagcccg gcacctgctt tgtcctgtac gagtggtgca 2160
tgaccgacaa gtacaacccc aatgacgagt accaccgcac aatcaagcac cgcatcgagc 2220
tgggcgacgg cctgccggag atggagacgt gcaaacaggt gatcgagtac atgaagcagg 2280
ccggcttcgt ggtggaggag gccatagacg tcatcagtca gttcgagtcc agccccatca 2340
agagtatccc gtggtaccag ccgctggtcg gcgactattc gtccctgcag ggcctgcgct 2400
ctaccccgat tggccgcatc ctcacgaacg tcatgtgtcg cgtgctggag ttcgtgcgcc 2460
tagctccgaa gggcacgtac aaggcgacgg agattttgga ggaggctgcg gaaagcctgg 2520
tggtgggcgg tcagctcggc atcttcacgc cgtccttcta catccgcgct cgcaagccgt 2580
ccaagcaggc t                                                      2591

<210> 39
<211> 863
<212> PRT
<213> Artificial Sequence

<220> 
<223> 8HNS Fusion Polypeptide

<400> 39
Met Lys Asp Lys Ala Thr Gly Lys Thr Gln Asn Ile Thr Ile Thr Ala
 1               5                  10                  15      
Asn Gly Gly Leu Ser Lys Glu Gln Ile Glu Gln Met Ile Arg Asp Ser
            20                  25                  30          
Glu Gln His Ala Glu Ala Asp Arg Val Lys Arg Glu Leu Val Glu Val
        35                  40                  45              
Arg Asn Asn Ala Glu Thr Gln Leu Thr Thr Ala Glu Arg Gln Leu Gly
    50                  55                  60                  
Glu Trp Lys Tyr Val Ser Asp Ala Glu Lys Glu Asn Val Lys Thr Leu
65                  70                  75                  80  
Val Ala Glu Leu Arg Lys Ala Met Glu Asn Pro Asn Val Ala Lys Asp
                85                  90                  95      
Asp Leu Ala Ala Ala Thr Asp Lys Leu Gln Lys Ala Val Met Glu Cys
            100                 105                 110         
Gly Arg Thr Glu Tyr Gln Gln Ala Ala Ala Ala Asn Ser Gly Ser Thr
        115                 120                 125             
Ser Asn Ser Gly Glu Gln Gln Gln Gln Gln Gly Gln Gly Glu Gln Gln
    130                 135                 140                 
Gln Gln Gln Asn Ser Glu Glu Lys Lys Ala Ser Ser Arg Ser Ala Pro
145                 150                 155                 160 
Arg Lys Ala Ser His Ala His Lys Ser His Arg Lys Pro Lys Arg Ser
                165                 170                 175     
Trp Asn Val Tyr Val Gly Arg Ser Leu Lys Ala Ile Asn Ala Gln Met
            180                 185                 190         
Ser Met Ser His Arg Thr Met Pro Arg Lys Ile Ile Leu Asp Cys Asp
        195                 200                 205             
Pro Gly Ile Asp Asp Ala Val Ala Ile Phe Leu Ala His Gly Asn Pro
    210                 215                 220                 
Glu Val Glu Leu Leu Ala Ile Thr Thr Val Val Gly Asn Gln Thr Leu
225                 230                 235                 240 
Glu Lys Val Thr Arg Asn Ala Arg Leu Val Ala Asp Val Ala Gly Ile
                245                 250                 255     
Val Gly Val Pro Val Ala Ala Gly Cys Thr Lys Pro Leu Val Arg Gly
            260                 265                 270         
Val Arg Asn Ala Ser Gln Ile His Gly Glu Thr Gly Met Gly Asn Val
        275                 280                 285             
Ser Tyr Pro Pro Glu Phe Lys Thr Lys Leu Asp Gly Arg His Ala Val
    290                 295                 300                 
Gln Leu Ile Ile Asp Leu Ile Met Ser His Glu Pro Lys Thr Ile Thr
305                 310                 315                 320 
Leu Val Pro Thr Gly Gly Leu Thr Asn Ile Ala Met Ala Val Arg Leu
                325                 330                 335     
Glu Pro Arg Ile Val Asp Arg Val Lys Glu Val Val Leu Met Gly Gly
            340                 345                 350         
Gly Tyr His Thr Gly Asn Ala Ser Pro Val Ala Glu Phe Asn Val Phe
        355                 360                 365             
Val Asp Pro Glu Ala Ala His Ile Val Phe Asn Glu Ser Trp Asn Val
    370                 375                 380                 
Thr Met Val Gly Leu Asp Leu Thr His Gln Ala Leu Ala Thr Pro Ala
385                 390                 395                 400 
Val Gln Lys Arg Val Lys Glu Val Gly Thr Lys Pro Ala Ala Phe Met
                405                 410                 415     
Leu Gln Ile Leu Asp Phe Tyr Thr Lys Val Tyr Glu Lys Glu Arg Asn
            420                 425                 430         
Thr Tyr Ala Thr Val His Asp Pro Cys Ala Val Ala Tyr Val Ile Asp
        435                 440                 445             
Pro Thr Val Met Thr Thr Glu Gln Val Pro Val Asp Ile Glu Leu Asn
    450                 455                 460                 
Gly Ala Leu Thr Thr Gly Met Thr Val Ala Asp Phe Arg Tyr Pro Arg
465                 470                 475                 480 
Pro Lys His Cys His Thr Gln Val Ala Val Lys Leu Asp Phe Asp Lys
                485                 490                 495     
Phe Trp Cys Leu Val Ile Asp Ala Leu Lys Arg Ile Gly Asp Pro Gln
            500                 505                 510         
Ser Ala Gly Gly Arg Glu Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg
        515                 520                 525             
Asn Lys Asp Glu Thr Asn Gly Asp Val Ser Ala Ala Ala Asp Arg Phe
    530                 535                 540                 
Arg Asp Arg Phe Glu Lys Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr
545                 550                 555                 560 
Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu
                565                 570                 575     
Tyr Gly Trp Gly Gln Asn Phe His Phe Ala Pro Arg Tyr Ala Gly Glu
            580                 585                 590         
Thr Phe Phe Glu Ser Leu Ala Arg His Glu Tyr Phe Leu Ala Ala Arg
        595                 600                 605             
Gly Gly Phe Met Glu Gly Asp His Ile Val Asp Val Gly Cys Gly Val
    610                 615                 620                 
Gly Gly Pro Ala Arg Asn Met Val Arg Leu Thr Arg Cys Asn Val Ile
625                 630                 635                 640 
Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser Arg Ala Arg Arg His Asp
                645                 650                 655     
Ala Leu Ala Gly Met Ser Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe
            660                 665                 670         
Cys Asn Met Ser Leu Ala Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile
        675                 680                 685             
Glu Ala Thr Cys His Ala Lys Asp Lys Val Lys Cys Tyr Ser Glu Val
    690                 695                 700                 
Phe Arg Val Ile Lys Pro Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys
705                 710                 715                 720 
Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu Tyr His Arg Thr Ile Lys
                725                 730                 735     
His Arg Ile Glu Leu Gly Asp Gly Leu Pro Glu Met Glu Thr Cys Lys
            740                 745                 750         
Gln Val Ile Glu Tyr Met Gln Ala Gly Phe Val Val Glu Glu Ala Ile
        755                 760                 765             
Asp Val Ile Ser Gln Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp
    770                 775                 780                 
Tyr Gln Pro Leu Val Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser
785                 790                 795                 800 
Thr Pro Ile Gly Arg Ile Leu Thr Asn Val Met Cys Arg Val Leu Glu
                805                 810                 815     
Phe Val Arg Leu Ala Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu
            820                 825                 830         
Glu Glu Ala Ala Glu Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe
        835                 840                 845             
Thr Pro Ser Phe Tyr Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala
    850                 855                 860             


<210> 40
<211> 2706
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide encoding H21NS Fusion Polypeptide

<400> 40
atggcctctt ctcgctctgc tccccgcaag gcttcccacg cgcacaagtc gcaccgcaag 60
ccgaagcgct cgtggaacgt gtacgtgggc cgctcgctga aggcgatcaa cgcccagatg 120
tcgatgtcgc accgcacgag cattatcaag gaggacgacg ccgtgggctg ctacatgacg 180
gtgaccctcg tggacgacac caaggtggag ggtaccatct tcacctacaa tcccaaggaa 240
ggcatcatag tacttctgtc cctccgcgac gatcagacga acatgaagct gatccgcact 300
ccatacatca aagagttcag tatttcacac gctgaggagg gaacgcacct gcctccggca 360
ctggactcct tcaacgagct tccgtccatg catgccggcc gcgacaagtc catcttcaag 420
cacgccagca cgcagctcaa gaacgccgag gcgaaccgcg aaaagcactt caactctgtc 480
acgaccgaca caccgattgc cacactcgat gcgtacctca agctcctgcg gctatacccc 540
ttcattgagt ggaacagcga cgagggtgtc atccaggtct cggataccgt cattgtcgta 600
ggggaccccg actggcggac gcccaaggcg atgctggtag acggcgcccc tgagaaggac 660
agaccgctcg tagaccgcct gcaggttgcg ctcggaaacg gcaagaagat gccgcgcaag 720
attattctcg attgtgatcc cgggatcgat gatgccgtgg ccatctttct cgcccacggc 780
aacccggagg tcgagctgct ggccattacg acggtggtgg gcaaccagac cctggagaag 840
gtgacccgga acgcgcggct ggtagctgac gtagccggca tcgttggtgt gcccgtcgcg 900
gctggttgca ccaagcccct cgtgcgcggt gtgcggaatg cctctcagat tcatggcgaa 960
accggcatgg gtaacgtctc ctacccacca gagttcaaga caaagttgga cggccgtcat 1020
gcagtgcagc tgatcatcga ccttatcatg tcgcacgagc cgaagacgat cacgcttgtg 1080
cctacgggtg gcctgacgaa cattgcgatg gctgtccgtc ttgagccgcg catcgtggac 1140
cgtgtgaagg aggtggttct gatgggtggc ggctaccata ctggtaatgc gtcccctgta 1200
gcggagttca acgtcttcgt cgacccggag gcggcgcaca ttgtgttcaa cgagagctgg 1260
aacgtaacga tggtggggct ggacctaacg caccaggcac tcgccacgcc ggcggtccag 1320
aagcgagtga aggaggtggg cacgaagccg gctgccttca tgctgcagat tttggacttt 1380
tacacgaagg tgtacgaaaa ggagcgcaac acgtacgcga cggtgcacga tccctgcgct 1440
gtggcgtacg tgattgaccc caccgtgatg acgacggagc aagtgccagt ggacatcgag 1500
ctcaatgggg cactgacgac tgggatgacg gtcgcggact tccgctaccc acggccaaag 1560
cactgccaca cgcaggtggc tgtgaagctg gacttcgaca agttttggtg cctcgtgatt 1620
gacgcactca agcgcatcgg cgatcctcaa tccgccggtg gccgtgagac cgcgccgacg 1680
aacctgattc gtcgccgcaa caaggacgag acaaacgggg atgtcagcgc cgccgccgac 1740
cgcttccgcg accgcttcga gaaggcaacc ctcgaggagc gcaaggccgc caccacgacg 1800
atggtcaacg agtactacga cctggtgacg gacttctacg agtacggctg gggccagaac 1860
ttccatttcg cgccgcgcta cgccggcgag accttcttcg agtccctcgc gcgccacgag 1920
tacttcctgg ccgctcgcgg cggcttcatg gagggcgacc acatcgtcga cgtgggctgc 1980
ggcgtcggcg gtccggcgcg caacatggtt cgcctcacgc gctgcaacgt catcggcgtc 2040
aacaacaacg attaccagat cagccgcgct cgccgtcatg acgcgctcgc cggtatgagc 2100
tccaagatcg actacgtcaa gaccgacttc tgcaacatga gcttagccga caacaccttc 2160
gacggcgcct acgccatcga ggccacctgc cacgcaaagg acaaggtcaa gtgctatagc 2220
gaggtcttcc gtgtcatcaa gcccggcacc tgctttgtcc tgtacgagtg gtgcatgacc 2280
gacaagtaca accccaatga cgagtaccac cgcacaatca agcaccgcat cgagctgggc 2340
gacggcctgc cggagatgga gacgtgcaaa caggtgatcg agtacatgaa gcaggccggc 2400
ttcgtggtgg aggaggccat agacgtcatc agtcagttcg agtccagccc catcaagagt 2460
atcccgtggt accagccgct ggtcggcgac tattcgtccc tgcagggcct gcgctctacc 2520
ccgattggcc gcatcctcac gaacgtcatg tgtcgcgtgc tggagttcgt gcgcctagct 2580
ccgaagggca cgtacaaggc gacggagatt ttggaggagg ctgcggaaag cctggtggtg 2640
ggcggtcagc tcggcatctt cacgccgtcc ttctacatcc gcgctcgcaa gccgtccaag 2700
caggct                                                            2706

<210> 41
<211> 902
<212> PRT
<213> Artificial Sequence

<220> 
<223> H21NS Fusion Polypeptide

<400> 41
Met Ala Ser Ser Arg Ser Ala Pro Arg Lys Ala Ser His Ala His Lys
 1               5                  10                  15      
Ser His Arg Lys Pro Lys Arg Ser Trp Asn Val Tyr Val Gly Arg Ser
            20                  25                  30          
Leu Lys Ala Ile Asn Ala Gln Met Ser Met Ser His Arg Thr Ser Ile
        35                  40                  45              
Ile Lys Glu Asp Asp Ala Val Gly Cys Tyr Met Thr Val Thr Leu Val
    50                  55                  60                  
Asp Asp Thr Lys Val Glu Gly Thr Ile Phe Thr Tyr Asn Pro Lys Glu
65                  70                  75                  80  
Gly Ile Ile Val Leu Leu Ser Leu Arg Asp Asp Gln Thr Asn Met Lys
                85                  90                  95      
Leu Ile Arg Thr Pro Tyr Ile Lys Glu Phe Ser Ile Ser His Ala Glu
            100                 105                 110         
Glu Gly Thr His Leu Pro Pro Ala Leu Asp Ser Phe Asn Glu Leu Pro
        115                 120                 125             
Ser Met His Ala Gly Arg Asp Lys Ser Ile Phe Lys His Ala Ser Thr
    130                 135                 140                 
Gln Leu Lys Asn Ala Glu Ala Asn Arg Glu Lys His Phe Asn Ser Val
145                 150                 155                 160 
Thr Thr Asp Thr Pro Ile Ala Thr Leu Asp Ala Tyr Leu Lys Leu Leu
                165                 170                 175     
Arg Leu Tyr Pro Phe Ile Glu Trp Asn Ser Asp Glu Gly Val Ile Gln
            180                 185                 190         
Val Ser Asp Thr Val Ile Val Val Gly Asp Pro Asp Trp Arg Thr Pro
        195                 200                 205             
Lys Ala Met Leu Val Asp Gly Ala Pro Glu Lys Asp Arg Pro Leu Val
    210                 215                 220                 
Asp Arg Leu Gln Val Ala Leu Gly Asn Gly Lys Lys Met Pro Arg Lys
225                 230                 235                 240 
Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala Val Ala Ile Phe
                245                 250                 255     
Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala Ile Thr Thr Val
            260                 265                 270         
Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn Ala Arg Leu Val
        275                 280                 285             
Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala Ala Gly Cys Thr
    290                 295                 300                 
Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln Ile His Gly Glu
305                 310                 315                 320 
Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe Lys Thr Lys Leu
                325                 330                 335     
Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu Ile Met Ser His
            340                 345                 350         
Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly Leu Thr Asn Ile
        355                 360                 365             
Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp Arg Val Lys Glu
    370                 375                 380                 
Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn Ala Ser Pro Val
385                 390                 395                 400 
Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala His Ile Val Phe
                405                 410                 415     
Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp Leu Thr His Gln
            420                 425                 430         
Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys Glu Val Gly Thr
        435                 440                 445             
Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe Tyr Thr Lys Val
    450                 455                 460                 
Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His Asp Pro Cys Ala
465                 470                 475                 480 
Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr Glu Gln Val Pro
                485                 490                 495     
Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly Met Thr Val Ala
            500                 505                 510         
Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr Gln Val Ala Val
        515                 520                 525             
Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile Asp Ala Leu Lys
    530                 535                 540                 
Arg Ile Gly Asp Pro Gln Ser Ala Gly Gly Arg Glu Thr Ala Pro Thr
545                 550                 555                 560 
Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn Gly Asp Val Ser
                565                 570                 575     
Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys Ala Thr Leu Glu
            580                 585                 590         
Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu Tyr Tyr Asp Leu
        595                 600                 605             
Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn Phe His Phe Ala
    610                 615                 620                 
Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu Ala Arg His Glu
625                 630                 635                 640 
Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly Asp His Ile Val
                645                 650                 655     
Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn Met Val Arg Leu
            660                 665                 670         
Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp Tyr Gln Ile Ser
        675                 680                 685             
Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser Ser Lys Ile Asp
    690                 695                 700                 
Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala Asp Asn Thr Phe
705                 710                 715                 720 
Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala Lys Asp Lys Val
                725                 730                 735     
Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro Gly Thr Cys Phe
            740                 745                 750         
Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn Pro Asn Asp Glu
        755                 760                 765             
Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly Asp Gly Leu Pro
    770                 775                 780                 
Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met Lys Gln Ala Gly
785                 790                 795                 800 
Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln Phe Glu Ser Ser
                805                 810                 815     
Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val Gly Asp Tyr Ser
            820                 825                 830         
Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg Ile Leu Thr Asn
        835                 840                 845             
Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala Pro Lys Gly Thr
    850                 855                 860                 
Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu Ser Leu Val Val
865                 870                 875                 880 
Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr Ile Arg Ala Arg
                885                 890                 895     
Lys Pro Ser Lys Gln Ala
            900         


<210> 42
<211> 226
<212> PRT
<213> Artificial Sequence

<220> 
<223> Putative eukaryotic initiation factor 4a
      polypeptide (Leif) from Leishmania major

<400> 42
Met Ala Gln Asn Asp Lys Ile Ala Pro Gln Asp Gln Asp Ser Phe Leu
 1               5                  10                  15      
Asp Asp Gln Pro Gly Val Arg Pro Ile Pro Ser Phe Asp Asp Met Pro
            20                  25                  30          
Leu His Gln Asn Leu Leu Arg Gly Ile Tyr Ser Tyr Gly Phe Glu Lys
        35                  40                  45              
Pro Ser Ser Ile Gln Gln Arg Ala Ile Ala Pro Phe Thr Arg Gly Gly
    50                  55                  60                  
Asp Ile Ile Ala Gln Ala Gln Ser Gly Thr Gly Lys Thr Gly Ala Phe
65                  70                  75                  80  
Ser Ile Gly Leu Leu Gln Arg Leu Asp Phe Arg His Asn Leu Ile Gln
                85                  90                  95      
Gly Leu Val Leu Ser Pro Thr Arg Glu Leu Ala Leu Gln Thr Ala Glu
            100                 105                 110         
Val Ile Ser Arg Ile Gly Glu Phe Leu Ser Asn Ser Ser Lys Phe Cys
        115                 120                 125             
Glu Thr Phe Val Gly Gly Thr Arg Val Gln Asp Asp Leu Arg Lys Leu
    130                 135                 140                 
Gln Ala Gly Val Ile Val Ala Val Gly Thr Pro Gly Arg Val Ser Asp
145                 150                 155                 160 
Val Ile Lys Arg Gly Ala Leu Arg Thr Glu Ser Leu Arg Val Leu Val
                165                 170                 175     
Leu Asp Glu Ala Asp Glu Met Leu Ser Gln Gly Phe Ala Asp Gln Ile
            180                 185                 190         
Tyr Glu Ile Phe Arg Phe Leu Pro Lys Asp Ile Gln Val Ala Leu Phe
        195                 200                 205             
Ser Ala Thr Met Pro Glu Glu Val Leu Glu Leu Thr Lys Lys Phe Met
    210                 215                 220                 
Arg Asp
225     


<210> 43
<211> 892
<212> PRT
<213> Artificial Sequence

<220> 
<223> NSL fusion polypeptide

<400> 43
Met Pro Arg Lys Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala
 1               5                  10                  15      
Val Ala Ile Phe Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala
            20                  25                  30          
Ile Thr Thr Val Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn
        35                  40                  45              
Ala Arg Leu Val Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala
    50                  55                  60                  
Ala Gly Cys Thr Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln
65                  70                  75                  80  
Ile His Gly Glu Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe
                85                  90                  95      
Lys Thr Lys Leu Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu
            100                 105                 110         
Ile Met Ser His Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly
        115                 120                 125             
Leu Thr Asn Ile Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp
    130                 135                 140                 
Arg Val Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn
145                 150                 155                 160 
Ala Ser Pro Val Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala
                165                 170                 175     
His Ile Val Phe Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp
            180                 185                 190         
Leu Thr His Gln Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys
        195                 200                 205             
Glu Val Gly Thr Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe
    210                 215                 220                 
Tyr Thr Lys Val Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His
225                 230                 235                 240 
Asp Pro Cys Ala Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr
                245                 250                 255     
Glu Gln Val Pro Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly
            260                 265                 270         
Met Thr Val Ala Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr
        275                 280                 285             
Gln Val Ala Val Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile
    290                 295                 300                 
Asp Ala Leu Lys Arg Ile Gly Asp Pro Gln Ser Ala Gly Gly Arg Glu
305                 310                 315                 320 
Thr Ala Pro Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn
                325                 330                 335     
Gly Asp Val Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys
            340                 345                 350         
Ala Thr Leu Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu
        355                 360                 365             
Tyr Tyr Asp Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn
    370                 375                 380                 
Phe His Phe Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu
385                 390                 395                 400 
Ala Arg His Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly
                405                 410                 415     
Asp His Ile Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn
            420                 425                 430         
Met Val Arg Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp
        435                 440                 445             
Tyr Gln Ile Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser
    450                 455                 460                 
Ser Lys Ile Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala
465                 470                 475                 480 
Asp Asn Thr Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala
                485                 490                 495     
Lys Asp Lys Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro
            500                 505                 510         
Gly Thr Cys Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn
        515                 520                 525             
Pro Asn Asp Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly
    530                 535                 540                 
Asp Gly Leu Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met
545                 550                 555                 560 
Lys Gln Ala Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln
                565                 570                 575     
Phe Glu Ser Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val
            580                 585                 590         
Gly Asp Tyr Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg
        595                 600                 605             
Ile Leu Thr Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala
    610                 615                 620                 
Pro Lys Gly Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu
625                 630                 635                 640 
Ser Leu Val Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr
                645                 650                 655     
Ile Arg Ala Arg Lys Pro Ser Lys Gln Ala Met Ala Gln Asn Asp Lys
            660                 665                 670         
Ile Ala Pro Gln Asp Gln Asp Ser Phe Leu Asp Asp Gln Pro Gly Val
        675                 680                 685             
Arg Pro Ile Pro Ser Phe Asp Asp Met Pro Leu His Gln Asn Leu Leu
    690                 695                 700                 
Arg Gly Ile Tyr Ser Tyr Gly Phe Glu Lys Pro Ser Ser Ile Gln Gln
705                 710                 715                 720 
Arg Ala Ile Ala Pro Phe Thr Arg Gly Gly Asp Ile Ile Ala Gln Ala
                725                 730                 735     
Gln Ser Gly Thr Gly Lys Thr Gly Ala Phe Ser Ile Gly Leu Leu Gln
            740                 745                 750         
Arg Leu Asp Phe Arg His Asn Leu Ile Gln Gly Leu Val Leu Ser Pro
        755                 760                 765             
Thr Arg Glu Leu Ala Leu Gln Thr Ala Glu Val Ile Ser Arg Ile Gly
    770                 775                 780                 
Glu Phe Leu Ser Asn Ser Ser Lys Phe Cys Glu Thr Phe Val Gly Gly
785                 790                 795                 800 
Thr Arg Val Gln Asp Asp Leu Arg Lys Leu Gln Ala Gly Val Ile Val
                805                 810                 815     
Ala Val Gly Thr Pro Gly Arg Val Ser Asp Val Ile Lys Arg Gly Ala
            820                 825                 830         
Leu Arg Thr Glu Ser Leu Arg Val Leu Val Leu Asp Glu Ala Asp Glu
        835                 840                 845             
Met Leu Ser Gln Gly Phe Ala Asp Gln Ile Tyr Glu Ile Phe Arg Phe
    850                 855                 860                 
Leu Pro Lys Asp Ile Gln Val Ala Leu Phe Ser Ala Thr Met Pro Glu
865                 870                 875                 880 
Glu Val Leu Glu Leu Thr Lys Lys Phe Met Arg Asp
                885                 890         


<210> 44
<211> 1001
<212> PRT
<213> Artificial Sequence

<220> 
<223> HNSC fusion polypeptide

<400> 44
Met Ala Ser Ser Arg Ser Ala Pro Arg Lys Ala Ser His Ala His Lys
 1               5                  10                  15      
Ser His Arg Lys Pro Lys Arg Ser Trp Asn Val Tyr Val Gly Arg Ser
            20                  25                  30          
Leu Lys Ala Ile Asn Ala Gln Met Ser Met Ser His Arg Thr Pro Arg
        35                  40                  45              
Lys Ile Ile Leu Asp Cys Asp Pro Gly Ile Asp Asp Ala Val Ala Ile
    50                  55                  60                  
Phe Leu Ala His Gly Asn Pro Glu Val Glu Leu Leu Ala Ile Thr Thr
65                  70                  75                  80  
Val Val Gly Asn Gln Thr Leu Glu Lys Val Thr Arg Asn Ala Arg Leu
                85                  90                  95      
Val Ala Asp Val Ala Gly Ile Val Gly Val Pro Val Ala Ala Gly Cys
            100                 105                 110         
Thr Lys Pro Leu Val Arg Gly Val Arg Asn Ala Ser Gln Ile His Gly
        115                 120                 125             
Glu Thr Gly Met Gly Asn Val Ser Tyr Pro Pro Glu Phe Lys Thr Lys
    130                 135                 140                 
Leu Asp Gly Arg His Ala Val Gln Leu Ile Ile Asp Leu Ile Met Ser
145                 150                 155                 160 
His Glu Pro Lys Thr Ile Thr Leu Val Pro Thr Gly Gly Leu Thr Asn
                165                 170                 175     
Ile Ala Met Ala Val Arg Leu Glu Pro Arg Ile Val Asp Arg Val Lys
            180                 185                 190         
Glu Val Val Leu Met Gly Gly Gly Tyr His Thr Gly Asn Ala Ser Pro
        195                 200                 205             
Val Ala Glu Phe Asn Val Phe Val Asp Pro Glu Ala Ala His Ile Val
    210                 215                 220                 
Phe Asn Glu Ser Trp Asn Val Thr Met Val Gly Leu Asp Leu Thr His
225                 230                 235                 240 
Gln Ala Leu Ala Thr Pro Ala Val Gln Lys Arg Val Lys Glu Val Gly
                245                 250                 255     
Thr Lys Pro Ala Ala Phe Met Leu Gln Ile Leu Asp Phe Tyr Thr Lys
            260                 265                 270         
Val Tyr Glu Lys Glu Arg Asn Thr Tyr Ala Thr Val His Asp Pro Cys
        275                 280                 285             
Ala Val Ala Tyr Val Ile Asp Pro Thr Val Met Thr Thr Glu Gln Val
    290                 295                 300                 
Pro Val Asp Ile Glu Leu Asn Gly Ala Leu Thr Thr Gly Met Thr Val
305                 310                 315                 320 
Ala Asp Phe Arg Tyr Pro Arg Pro Lys His Cys His Thr Gln Val Ala
                325                 330                 335     
Val Lys Leu Asp Phe Asp Lys Phe Trp Cys Leu Val Ile Asp Ala Leu
            340                 345                 350         
Lys Arg Ile Gly Asp Pro Gln Ser Ala Gly Gly Arg Glu Thr Ala Pro
        355                 360                 365             
Thr Asn Leu Ile Arg Arg Arg Asn Lys Asp Glu Thr Asn Gly Asp Val
    370                 375                 380                 
Ser Ala Ala Ala Asp Arg Phe Arg Asp Arg Phe Glu Lys Ala Thr Leu
385                 390                 395                 400 
Glu Glu Arg Lys Ala Ala Thr Thr Thr Met Val Asn Glu Tyr Tyr Asp
                405                 410                 415     
Leu Val Thr Asp Phe Tyr Glu Tyr Gly Trp Gly Gln Asn Phe His Phe
            420                 425                 430         
Ala Pro Arg Tyr Ala Gly Glu Thr Phe Phe Glu Ser Leu Ala Arg His
        435                 440                 445             
Glu Tyr Phe Leu Ala Ala Arg Gly Gly Phe Met Glu Gly Asp His Ile
    450                 455                 460                 
Val Asp Val Gly Cys Gly Val Gly Gly Pro Ala Arg Asn Met Val Arg
465                 470                 475                 480 
Leu Thr Arg Cys Asn Val Ile Gly Val Asn Asn Asn Asp Tyr Gln Ile
                485                 490                 495     
Ser Arg Ala Arg Arg His Asp Ala Leu Ala Gly Met Ser Ser Lys Ile
            500                 505                 510         
Asp Tyr Val Lys Thr Asp Phe Cys Asn Met Ser Leu Ala Asp Asn Thr
        515                 520                 525             
Phe Asp Gly Ala Tyr Ala Ile Glu Ala Thr Cys His Ala Lys Asp Lys
    530                 535                 540                 
Val Lys Cys Tyr Ser Glu Val Phe Arg Val Ile Lys Pro Gly Thr Cys
545                 550                 555                 560 
Phe Val Leu Tyr Glu Trp Cys Met Thr Asp Lys Tyr Asn Pro Asn Asp
                565                 570                 575     
Glu Tyr His Arg Thr Ile Lys His Arg Ile Glu Leu Gly Asp Gly Leu
            580                 585                 590         
Pro Glu Met Glu Thr Cys Lys Gln Val Ile Glu Tyr Met Lys Gln Ala
        595                 600                 605             
Gly Phe Val Val Glu Glu Ala Ile Asp Val Ile Ser Gln Phe Glu Ser
    610                 615                 620                 
Ser Pro Ile Lys Ser Ile Pro Trp Tyr Gln Pro Leu Val Gly Asp Tyr
625                 630                 635                 640 
Ser Ser Leu Gln Gly Leu Arg Ser Thr Pro Ile Gly Arg Ile Leu Thr
                645                 650                 655     
Asn Val Met Cys Arg Val Leu Glu Phe Val Arg Leu Ala Pro Lys Gly
            660                 665                 670         
Thr Tyr Lys Ala Thr Glu Ile Leu Glu Glu Ala Ala Glu Ser Leu Val
        675                 680                 685             
Val Gly Gly Gln Leu Gly Ile Phe Thr Pro Ser Phe Tyr Ile Arg Ala
    690                 695                 700                 
Arg Lys Pro Ser Lys Gln Ala Ser Ala Val Gly Asn Ile Glu Ser Gln
705                 710                 715                 720 
Trp Ala Arg Ala Gly His Gly Leu Val Ser Leu Ser Glu Gln Gln Leu
                725                 730                 735     
Val Ser Cys Asp Asp Lys Asp Asn Gly Cys Asn Gly Gly Leu Met Leu
            740                 745                 750         
Gln Ala Phe Glu Trp Leu Leu Arg His Met Tyr Gly Ile Val Phe Thr
        755                 760                 765             
Glu Lys Ser Tyr Pro Tyr Thr Ser Gly Asn Gly Asp Val Ala Glu Cys
    770                 775                 780                 
Leu Asn Ser Ser Lys Leu Val Pro Gly Ala Gln Ile Asp Gly Tyr Val
785                 790                 795                 800 
Met Ile Pro Ser Asn Glu Thr Val Met Ala Ala Trp Leu Ala Glu Asn
                805                 810                 815     
Gly Pro Ile Ala Ile Ala Val Asp Ala Ser Ser Phe Met Ser Tyr Gln
            820                 825                 830         
Ser Gly Val Leu Thr Ser Cys Ala Gly Asp Ala Leu Asn His Gly Val
        835                 840                 845             
Leu Leu Val Gly Tyr Asn Lys Thr Gly Gly Val Pro Tyr Trp Val Ile
    850                 855                 860                 
Lys Asn Ser Trp Gly Glu Asp Trp Gly Glu Lys Gly Tyr Val Arg Val
865                 870                 875                 880 
Val Met Gly Leu Asn Ala Cys Leu Leu Ser Glu Tyr Pro Val Ser Ala
                885                 890                 895     
His Val Pro Arg Ser Leu Thr Pro Gly Pro Gly Thr Glu Ser Glu Glu
            900                 905                 910         
Arg Ala Pro Lys Arg Val Thr Val Glu Gln Met Met Cys Thr Asp Met
        915                 920                 925             
Tyr Cys Arg Glu Gly Cys Lys Lys Ser Leu Leu Thr Ala Asn Val Cys
    930                 935                 940                 
Tyr Lys Asn Gly Gly Gly Gly Ser Ser Met Thr Lys Cys Gly Pro Gln
945                 950                 955                 960 
Lys Val Leu Met Cys Ser Tyr Ser Asn Pro His Cys Phe Gly Pro Gly
                965                 970                 975     
Leu Cys Leu Glu Thr Pro Asp Gly Lys Cys Ala Pro Tyr Phe Leu Gly
            980                 985                 990         
Ser Ile Met Asn Thr Cys Gln Tyr Thr
        995                 1000    


<210> 45
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
atgcatcacc atcaccatca c                                           21