                         SEQUENCE LISTING

<110>  Health Research, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR USE OF RECOMBINANT T CELL RECEPTORS 
       FOR DIRECT RECOGNITION OF TUMOR ANTIGEN

<130>  003551.00526

<150>  61/778,673
<151>  2013-03-13

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  798
<212>  DNA
<213>  human

<400>  1
atgaagttgg tgacaagcat tactgtactc ctatctttgg gtattatggg tgatgctaag       60

accacacagc caaattcaat ggagagtaac gaagaagagc ctgttcactt gccttgtaac      120

cactccacaa tcagtggaac tgattacata cattggtatc gacagcttcc ctcccagggt      180

ccagagtacg tgattcatgg tcttacaagc aatgtgaaca acagaatggc ctctctggca      240

atcgctgaag acagaaagtc cagtaccttg atcctgcacc gtgctacctt gagagatgct      300

gctgtgtact actgcatccc taataacaat gacatgcgct ttggagcagg gaccagactg      360

acagtaaaac caaatatcca gaaccctgac cctgccgtgt accagctgag agactctaaa      420

tccagtgaca agtctgtctg cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa      480

agtaaggatt ctgatgtgta tatcacagac aaaactgtgc tagacatgag gtctatggac      540

ttcaagagca acagtgctgt ggcctggagc aacaaatctg actttgcatg tgcaaacgcc      600

ttcaacaaca gcattattcc agaagacacc ttcttcccca gcccagaaag ttcctgtgat      660

gtcaagctgg tcgagaaaag ctttgaaaca gatacgaacc taaactttca aaacctgtca      720

gtgattgggt tccgaatcct cctcctgaaa gtggccgggt ttaatctgct catgacgctg      780

cggctgtggt ccagctga                                                    798


<210>  2
<211>  798
<212>  DNA
<213>  human

<400>  2
atgaagttgg tgacaagcat tactgtactc ctatctttgg gtattatggg tgatgctaag       60

accacacagc caaattcaat ggagagtaac gaagaagagc ctgttcactt gccttgtaac      120

cactccacaa tcagtggaac tgattacata cattggtatc gacagcttcc ctcccagggt      180

ccagagtacg tgattcatgg tcttacaagc aatgtgaaca acagaatggc ctctctggca      240

atcgctgaag acagaaagtc cagtaccttg atcctgcacc gtgctacctt gagagatgct      300

gctgtgtact actgcatccc taataacaat gacatgcgct ttggagcagg gaccagactg      360

acagtaaaac caaatatcca gaaccctgac cctgccgtgt accagctgag agactctaaa      420

tccagtgaca agtctgtctg cctattcacc gattttgatt ctcaaacaaa tgtgtcacaa      480

agtaaggatt ctgatgtgta tatcacagac aaaactgtgc tagacatgag gtctatggac      540

ttcaagagca acagtgctgt ggcctggagc aacaaatctg actttgcatg tgcaaacgcc      600

ttcaacaaca gcattattcc agaagacacc ttcttcccca gcccagaaag ttcctgtgat      660

gtcaagctgg tcgagaaaag ctttgaaaca gatacgaacc taaactttca aaacctgtca      720

gtgattgggt tccgaatcct cctcctgaaa gtggccgggt ttaatctgct catgacgctg      780

cggctgtggt ccagctga                                                    798


<210>  3
<211>  265
<212>  PRT
<213>  human

<400>  3

Met Lys Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Pro Asn Asn Asn Asp Met 
            100                 105                 110         


Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn Ile Gln Asn 
        115                 120                 125             


Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
    130                 135                 140                 


Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln 
145                 150                 155                 160 


Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met 
                165                 170                 175     


Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys 
            180                 185                 190         


Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu 
        195                 200                 205             


Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val 
    210                 215                 220                 


Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser 
225                 230                 235                 240 


Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
                245                 250                 255     


Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265 


<210>  4
<211>  310
<212>  PRT
<213>  human

<400>  4

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Phe Pro Arg Glu Pro Asn Tyr Gly Tyr Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Phe 
305                 310 


<210>  5
<211>  780
<212>  DNA
<213>  human

<400>  5
atggcccaga cagtcactca gtctcaacca gagatgtctg tgcaggaggc agagactgtg       60

accctgagtt gcacatatga caccagtgag aataattatt atttgttctg gtacaagcag      120

cctcccagca ggcagatgat tctcgttatt cgccaagaag cttataagca acagaatgca      180

acggagaatc gtttctctgt gaacttccag aaagcagcca aatccttcag tctcaagatc      240

tcagactcac agctggggga cactgcgatg tatttctgtg ctttctcgag agggagtgga      300

ggtagcaact ataaactgac atttggaaaa ggaactctct taaccgtgaa tccaaatatc      360

cagaaccctg accctgccgt gtaccagctg agagactcta aatccagtga caagtctgtc      420

tgcctattca ccgattttga ttctcaaaca aatgtgtcac aaagtaagga ttctgatgtg      480

tatatcacag acaaaactgt gctagacatg aggtctatgg acttcaagag caacagtgct      540

gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa cagcattatt      600

ccagaagaca ccttcttccc cagcccagaa agttcctgtg atgtcaagct ggtcgagaaa      660

agctttgaaa cagatacgaa cctaaacttt caaaacctgt cagtgattgg gttccgaatc      720

ctcctcctga aagtggccgg gtttaatctg ctcatgacgc tgcggctgtg gtccagctga      780


<210>  6
<211>  942
<212>  DNA
<213>  human

<400>  6
atgggcacca ggctcctctt ctgggtggcc ttctgtctcc tgggggcaga tcacacagga       60

gctggagtct cccagtcccc cagtaacaag gtcacagaga agggaaagga tgtagagctc      120

aggtgtgatc caatttcagg tcatactgcc ctttactggt accgacagag cctggggcag      180

ggcctggagt ttttaattta cttccaaggc aacagtgcac cagacaaatc agggctgccc      240

agtgatcgct tctctgcaga gaggactggg ggatccgtct ccactctgac gatccagcgc      300

acacagcagg aggactcggc cgtgtatctc tgtgccagca gcttagtccc cgacagtgcc      360

tacgagcagt acttcgggcc gggcaccagg ctcacggtca cagaggacct gaaaaacgtg      420

ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag      480

gccacactgg tatgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg      540

gtgaatggga aggaggtgca cagtggggtc agcacggacc cgcagcccct caaggagcag      600

cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc      660

tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat      720

gacgagtgga cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg      780

ggtagagcag actgtggctt cacctccgag tcttaccagc aaggggtcct gtctgccacc      840

atcctctatg agatcttgct agggaaggcc accttgtatg ccgtgctggt cagtgccctc      900

gtgctgatgg ccatggtcaa gagaaaggat tccagaggct ag                         942


<210>  7
<211>  259
<212>  PRT
<213>  human

<400>  7

Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser Val Gln Glu 
1               5                   10                  15      


Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser Glu Asn Asn 
            20                  25                  30          


Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln Met Ile Leu 
        35                  40                  45              


Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr Glu Asn Arg 
    50                  55                  60                  


Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser Leu Lys Ile 
65                  70                  75                  80  


Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys Ala Phe Ser 
                85                  90                  95      


Arg Gly Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr 
            100                 105                 110         


Leu Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
        115                 120                 125             


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
    130                 135                 140                 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
145                 150                 155                 160 


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
                165                 170                 175     


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
            180                 185                 190         


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
        195                 200                 205             


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
    210                 215                 220                 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
225                 230                 235                 240 


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
                245                 250                 255     


Trp Ser Ser 
            


<210>  8
<211>  313
<212>  PRT
<213>  human

<400>  8

Met Gly Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Val Pro Asp Ser Ala Tyr Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310             


<210>  9
<211>  828
<212>  DNA
<213>  human

<400>  9
atgctcctgc tgctcgtccc agtgctcgag gtgattttta ccctgggagg aaccagagcc       60

cagtcggtga cccagcttgg cagccacgtc tctgtctctg agggagccct ggttctgctg      120

aggtgcaact actcatcgtc tgttccacca tatctcttct ggtatgtgca ataccccaac      180

caaggactcc agcttctcct gaagcacaca acaggggcca ccctggttaa aggcatcaac      240

ggttttgagg ctgaatttaa gaagagtgaa acctccttcc acctgacgaa accctcagcc      300

catatgagcg acgcggctga gtacttctgt gctgtgagtg attctagggc tgcaggcaac      360

aagctaactt ttggaggagg aaccagggtg ctagttaaac caaatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaaactgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa      780

gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagctga                   828


<210>  10
<211>  936
<212>  DNA
<213>  human

<400>  10
atgggaatca ggctcctctg tcgtgtggcc ttttgtttcc tggctgtagg cctcgtagat       60

gtgaaagtaa cccagagctc gagatatcta gtcaaaagga cgggagagaa agtttttctg      120

gaatgtgtcc aggatatgga ccatgaaaat atgttctggt atcgacaaga cccaggtctg      180

gggctacggc tgatctattt ctcatatgat gttaaaatga aagaaaaagg agatattcct      240

gaggggtaca gtgtctctag agagaagaag gagcgcttct ccctgattct ggagtccgcc      300

agcaccaacc agacatctat gtacctctgt gccagcagat tccccgggac agcctataat      360

tcacccctcc actttgggaa tgggaccagg ctcactgtga cagaggacct gaacaaggtg      420

ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag      480

gccacactgg tgtgcctggc cacaggcttc ttccctgacc acgtggagct gagctggtgg      540

gtgaatggga aggaggtgca cagtggggtc agcacggacc cgcagcccct caaggagcag      600

cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc      660

tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat      720

gacgagtgga cccaggatag ggccaaaccc gtcacccaga tcgtcagcgc cgaggcctgg      780

ggtagagcag actgtggctt tacctcggtg tcctaccagc aaggggtcct gtctgccacc      840

atcctctatg agatcctgct agggaaggcc accctgtatg ctgtgctggt cagcgccctt      900

gtgttgatgg ccatggtcaa gagaaaggat ttctga                                936


<210>  11
<211>  275
<212>  PRT
<213>  human

<400>  11

Met Leu Leu Leu Leu Val Pro Val Leu Glu Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Gly Ser His Val Ser Val 
            20                  25                  30          


Ser Glu Gly Ala Leu Val Leu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Pro Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys His Thr Thr Gly Ala Thr Leu Val Lys Gly Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Lys Lys Ser Glu Thr Ser Phe His Leu Thr 
                85                  90                  95      


Lys Pro Ser Ala His Met Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Asp Ser Arg Ala Ala Gly Asn Lys Leu Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Arg Val Leu Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210>  12
<211>  311
<212>  PRT
<213>  human

<400>  12

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Arg Phe Pro Gly Thr Ala Tyr Asn Ser Pro Leu His Phe Gly Asn Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Phe 
305                 310     


