
                                SEQUENCE LISTING

<110> Icahn School of Medicine at Mount Sinai

<120> ANTIBODIES AGAINST INFLUENZA VIRUS
      HEMAGGLUTININ AND USES THEREOF  

<130> 6923-215-228

<140> to be assigned
<141> on even date herewith
 
<150> 61/783,532 
<151> 2013-03-14

<160> 32

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 381
<212> DNA
<213> Aritificial Sequence

<220> 
<223> variable heavy chain region of the monoclonal antibody GG3

<400> 1
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60
tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct 120
ccaggaaagg gtttaaagtg gatgggctgg ataaacatct acagtggaga gtcaacatat 180
gttgatgact tcacgggacg gtttgccttc tctttggaaa cctctgccag cactgcctat 240
ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aagatctggg 300
gatactatga ttacggcggg acggtccttc tttgctatgg actactgggg tcaaggaacc 360
tcagtcaccg tctcctcagc c                                           381

<210> 2
<211> 75
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VH FR1 region of the monoclonal antibody GG3

<400> 2
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc 60
tcctgcaagg cttct                                                  75

<210> 3
<211> 24
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VH CDR1 region of the monoclonal antibody GG3

<400> 3
gggtatacct tcacaaacta tgga                                        24

<210> 4
<211> 51
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VH FR2 region of the monoclonal antibody GG3

<400> 4
atgaactggg tgaagcaggc tccaggaaag ggtttaaagt ggatgggctg g          51

<210> 5
<211> 24
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VH CDR2 region of the monoclonal antibody GG3

<400> 5
ataaacatct acagtggaga gtca                                        24

<210> 6
<211> 114
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VH FR3 region of the monoclonal antibody GG3

<400> 6
acatatgttg atgacttcac gggacggttt gccttctctt tggaaacctc tgccagcact 60
gcctatttgc agatcaacaa cctcaaaaat gaggacatgg ctacatattt ctgt       114

<210> 7
<211> 57
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VH CDR3 region of the monoclonal antibody GG3

<400> 7
gcaagatctg gggatactat gattacggcg ggacggtcct tctttgctat ggactac    57

<210> 8
<211> 36
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VH FR4 region of the monoclonal antibody GG3

<400> 8
tggggtcaag gaacctcagt caccgtctcc tcagcc                           36

<210> 9
<211> 322
<212> DNA
<213> Aritificial Sequence

<220> 
<223> variable light chain region of the monoclonal antibody GG3

<400> 9
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt 60
ctcacttgtc gggcaagtca ggaaattagt ggttacttaa gctggcttca gcagaaacca 120
gatggaacta ttaaacgcct gatctacgcc gcatccactt tagattctgg tgtcccaaaa 180
aggttcagtg gcagtaggtc tgggtcagat tattctctct ccatcagcag ccttgagtct 240
gaagattttg cagactatta ctgtcttcaa tatgctaatt atccgtggtc gttcggtgga 300
ggcaccaagc tggaaatcaa ac                                          322

<210> 10
<211> 78
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VL FR1 region of the monoclonal antibody GG3

<400> 10
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt 60
ctcacttgtc gggcaagt                                               78

<210> 11
<211> 18
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VL CDR1 region of the monoclonal antibody GG3

<400> 11
caggaaatta gtggttac                                               18

<210> 12
<211> 51
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VL FR2 region of the monoclonal antibody GG3

<400> 12
ttaagctggc ttcagcagaa accagatgga actattaaac gcctgatcta c          51

<210> 13
<211> 9
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VL CDR2 region of the monoclonal antibody GG3

<400> 13
gccgcatcc                                                         9

<210> 14
<211> 108
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VL FR3 region of the monoclonal antibody GG3

<400> 14
actttagatt ctggtgtccc aaaaaggttc agtggcagta ggtctgggtc agattattct 60
ctctccatca gcagccttga gtctgaagat tttgcagact attactgt              108

<210> 15
<211> 27
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VL CDR3 region of the monoclonal antibody GG3

<400> 15
cttcaatatg ctaattatcc gtggtcg                                     27

<210> 16
<211> 31
<212> DNA
<213> Aritificial Sequence

<220> 
<223> VL FR4 region of the monoclonal antibody GG3

<400> 16
ttcggtggag gcaccaagct ggaaatcaaa c                                31

<210> 17
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> variable heavy chain region of the monoclonal antibody GG3

<400> 17
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Ile Tyr Ser Gly Glu Ser Thr Tyr Val Asp Asp Phe
    50                  55                  60                  
Thr Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Ser Gly Asp Thr Met Ile Thr Ala Gly Arg Ser Phe Phe Ala
            100                 105                 110         
Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala
        115                 120                 125         


<210> 18
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR1 region of the monoclonal antibody GG3

<400> 18
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser
            20                  25  


<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1 region of the monoclonal antibody GG3

<400> 19
Gly Tyr Thr Phe Thr Asn Tyr Gly
 1               5              


<210> 20
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR2 region of the monoclonal antibody GG3

<400> 20
Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly
 1               5                  10                  15      
Trp
    


<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR2 region of the monoclonal antibody GG3

<400> 21
Ile Asn Ile Tyr Ser Gly Glu Ser
 1               5              


<210> 22
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR3 region of the monoclonal antibody GG3

<400> 22
Thr Tyr Val Asp Asp Phe Thr Gly Arg Phe Ala Phe Ser Leu Glu Thr
 1               5                  10                  15      
Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp
            20                  25                  30          
Met Ala Thr Tyr Phe Cys
        35              


<210> 23
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR3 region of the monoclonal antibody GG3

<400> 23
Ala Arg Ser Gly Asp Thr Met Ile Thr Ala Gly Arg Ser Phe Phe Ala
 1               5                  10                  15      
Met Asp Tyr
            


<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR4 region of the monoclonal antibody GG3

<400> 24
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala
 1               5                  10          


<210> 25
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> variable light chain region of the monoclonal antibody GG3

<400> 25
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr
            20                  25                  30          
Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
    50                  55                  60                  
Ser Arg Ser Gly Ser Asp Tyr Ser Leu Ser Ile Ser Ser Leu Glu Ser
65                  70                  75                  80  
Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Asn Tyr Pro Trp
                85                  90                  95      
Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 26
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR1 region of the monoclonal antibody GG3

<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Glu Arg Val Ser Leu Thr Cys Arg Ala Ser
            20                  25      


<210> 27
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 chain region of the monoclonal antibody GG3

<400> 27
Gln Glu Ile Ser Gly Tyr
 1               5      


<210> 28
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR2 region of the monoclonal antibody GG3

<400> 28
Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile
 1               5                  10                  15      
Tyr
    


<210> 29
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2 region of the monoclonal antibody GG3

<400> 29
Ala Ala Ser
 1          


<210> 30
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR3 region of the monoclonal antibody GG3

<400> 30
Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly
 1               5                  10                  15      
Ser Asp Tyr Ser Leu Ser Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala
            20                  25                  30          
Asp Tyr Tyr Cys
        35      


<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR3 region of the monoclonal antibody GG3

<400> 31
Leu Gln Tyr Ala Asn Tyr Pro Trp Ser
 1               5                  


<210> 32
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR4 region of the monoclonal antibody GG3

<400> 32
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
 1               5                  10  

