                         SEQUENCE LISTING
<110>  Pioneer Hi-Bred International, Inc.
       Abad, Andre
       Liu, Lu
       Poland, Brad
       Schellenberger, Ute
       Udranszky, Ingrid
       Wang, Jimei
       Wei, Jun-Zhi
       Wolfe, Chad
       Xie, Weiping
       Zhenglin, Hou
       Zhou, Lan
       Zhu, Genhai
 
<120>  Insecticidal Proteins with activity against Hemiptera        and Methods of Use

<130>  5264-WO-PCT

<150>  13/803634
<151>  2013-03-14

<160>  69    
<170>  PatentIn version 3.5

<210>  1
<211>  774
<212>  DNA
<213>  Bacillus sphaericus
<220>
<221>  misc_feature
<222>  (1)..(777)
<223>  MP467S nucleotide sequence

<400>  1
atgacaattc aagaaaaatt atcatttaca gatttacctg cactaaaatc aagccccgag       60
agtgtaagac aagcattcac aaataagttt ggtacaaaac ctgatggcat ctctgtcaac      120
agtgaaactt attttaatgc tgtcaaacct gcaatcacag aacaatatgg acacccttgt      180
tataaaagac taggtgactt taattatatg aaaggcgatg gcaagccacc tacatctgca      240
atcgttggga gcaatgtagc agtaaactat ggagatgaag aggctacgat gactttagag      300
gttcaaggaa gctggcaaag tgagcaatct tggtcttctg aaagtacgac tggtctaacg      360
atatcctcca aatttacaat tgaaggattc tttgaatcag gaatggagtt ttctgtcagt      420
actactgttg gggaaacaaa aactgagtca gaatcaagaa cagccactgc cagtgtacaa      480
gtgactgtgc cgcctagaag taaaaaacaa gtaacaatgg ttggtacatt gaaaaaagaa      540
tccatgaact tccgagcacc tatttcagtt gatggcatgt ttggggcaaa cttccctaaa      600
cgagtacaag accattattt ctggttcctt ggtgcaggta gtgtattgac tcaaacaaca      660
ggagaaatca ctggtactat taaaaataca gctgtctttg atgttcatac ggaaattggc      720
aaaacagaac cattaactgc agaagagcta agcaaacttg ctgtattagc taag            774

<210>  2
<211>  258
<212>  PRT
<213>  Bacillus sphaericus
<220>
<221>  MISC_FEATURE
<222>  (1)..(258)
<223>  MP467S

<400>  2
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  3
<211>  735
<212>  DNA
<213>  Hydra vulgaris
<220>
<221>  misc_feature
<222>  (1)..(735)
<223>  hydralysin-2 nucleotide sequence

<400>  3
atgggtaaag agcttctaac ctttagtgat ctaacatggc tggacagtag tccagacact       60
gttcgaagtg cttttacgag acagtatggg acaacgcctg atggcattgc tctaaacagt      120
gaaggttact ttggttacca cagtccgcca atcactgaac agtatggccg tccatgctac      180
aaacagactg gcgaaacaaa aattacgttg caagacttag ctcctcctac ggatgctatt      240
ctcggaaact ctattgccag aaatcgaggt gactcgccga ttactttgac cgtaagcgtt      300
gaaggcaaat ggagcgattc tacaagctgg tcaacaagca cagaaacagg agtaaaaatg      360
tcaagtgagt ttggagttga aggagctttc aaaatgggag gagaattttc acttacggta      420
tcagtaggaa agtctggttc cagcagtgtg gaaaagactt caacttcatc tgttcaagta      480
actgttcctc cgcgttcgaa ggttgttgtt agcatggttg gtattatgaa aaaggaaaag      540
gtattcttcg aggttccagt caccgttgat ggaagtttcg gtgctaactt cccttcaaca      600
gttcaaggtc actacttttg gtttatggac gctcgcagtt gtctaaataa aacgtctggt      660
gtcatcaaag gtacgattga ccacgccaac gtgtttgacg tttcggttga agtcggacca      720
agtgagcctt tgtaa                                                       735

<210>  4
<211>  244
<212>  PRT
<213>  Hydra viridissima
<220>
<221>  MISC_FEATURE
<222>  (1)..(244)
<223>  hydralysin-2

<400>  4
Met Gly Lys Glu Leu Leu Thr Phe Ser Asp Leu Thr Trp Leu Asp Ser 
1               5                   10                  15      
Ser Pro Asp Thr Val Arg Ser Ala Phe Thr Arg Gln Tyr Gly Thr Thr 
            20                  25                  30          
Pro Asp Gly Ile Ala Leu Asn Ser Glu Gly Tyr Phe Gly Tyr His Ser 
        35                  40                  45              
Pro Pro Ile Thr Glu Gln Tyr Gly Arg Pro Cys Tyr Lys Gln Thr Gly 
    50                  55                  60                  
Glu Thr Lys Ile Thr Leu Gln Asp Leu Ala Pro Pro Thr Asp Ala Ile 
65                  70                  75                  80  
Leu Gly Asn Ser Ile Ala Arg Asn Arg Gly Asp Ser Pro Ile Thr Leu 
                85                  90                  95      
Thr Val Ser Val Glu Gly Lys Trp Ser Asp Ser Thr Ser Trp Ser Thr 
            100                 105                 110         
Ser Thr Glu Thr Gly Val Lys Met Ser Ser Glu Phe Gly Val Glu Gly 
        115                 120                 125             
Ala Phe Lys Met Gly Gly Glu Phe Ser Leu Thr Val Ser Val Gly Lys 
    130                 135                 140                 
Ser Gly Ser Ser Ser Val Glu Lys Thr Ser Thr Ser Ser Val Gln Val 
145                 150                 155                 160 
Thr Val Pro Pro Arg Ser Lys Val Val Val Ser Met Val Gly Ile Met 
                165                 170                 175     
Lys Lys Glu Lys Val Phe Phe Glu Val Pro Val Thr Val Asp Gly Ser 
            180                 185                 190         
Phe Gly Ala Asn Phe Pro Ser Thr Val Gln Gly His Tyr Phe Trp Phe 
        195                 200                 205             
Met Asp Ala Arg Ser Cys Leu Asn Lys Thr Ser Gly Val Ile Lys Gly 
    210                 215                 220                 
Thr Ile Asp His Ala Asn Val Phe Asp Val Ser Val Glu Val Gly Pro 
225                 230                 235                 240 
Ser Glu Pro Leu 
                

<210>  5
<211>  762
<212>  DNA
<213>  Bacillus thuringiensis
<220>
<221>  misc_feature
<222>  (1)..(762)
<223>  543S nucleotide sequence

<400>  5
atgattatac aagaaaaatt atctttttca gatctagatt cattagattc aactacagac       60
tccataatgg atgcgtttaa agatctttat ggaatacttc ctgacgaaat tgcattaaat      120
aatgagacgt ttccaattca taataagcct gctattactg aacgttatgg tcatgcttgt      180
tataaaatgc tgggcccttt tatatttcga tatcttgaag aaccttcaat aaatgaaata      240
accctaaagg aacaatttgt atataatcct aataatgaag aaaaagagat tgtagtgaca      300
ataaaagaac aatgggtcaa tatacaatct tggagttcga aatctattac aggtttaact      360
ttaaaatcag atcttattat tgcaggtaaa tttcaatcgg gtaatgaatt taatatttca      420
acttttgtag gagaaagtaa ttcaaaatca attcatacct ctccttcaat tgaacattct      480
attaaagtac ctccaaatag taaaatgaaa attgcaatga taggaacatt aattactgag      540
gttctacatt tccaatcaat tataacagta caaggcatgt ttggtgcatg ttttccacgt      600
atggttcgtg gacattatat tgggtttaaa agcgccggtc acatcctaaa taaaacgttt      660
ggaataattg aaggatctat taacaataca gcaattcagg atattgaaat aaatattaaa      720
gggatagaac cttattccta taaacaaaaa gtgatcaagt ag                         762

<210>  6
<211>  253
<212>  PRT
<213>  Bacillus thuringiensis
<220>
<221>  MISC_FEATURE
<222>  (1)..(253)
<223>  543S

<400>  6
Met Ile Ile Gln Glu Lys Leu Ser Phe Ser Asp Leu Asp Ser Leu Asp 
1               5                   10                  15      
Ser Thr Thr Asp Ser Ile Met Asp Ala Phe Lys Asp Leu Tyr Gly Ile 
            20                  25                  30          
Leu Pro Asp Glu Ile Ala Leu Asn Asn Glu Thr Phe Pro Ile His Asn 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Arg Tyr Gly His Ala Cys Tyr Lys Met Leu 
    50                  55                  60                  
Gly Pro Phe Ile Phe Arg Tyr Leu Glu Glu Pro Ser Ile Asn Glu Ile 
65                  70                  75                  80  
Thr Leu Lys Glu Gln Phe Val Tyr Asn Pro Asn Asn Glu Glu Lys Glu 
                85                  90                  95      
Ile Val Val Thr Ile Lys Glu Gln Trp Val Asn Ile Gln Ser Trp Ser 
            100                 105                 110         
Ser Lys Ser Ile Thr Gly Leu Thr Leu Lys Ser Asp Leu Ile Ile Ala 
        115                 120                 125             
Gly Lys Phe Gln Ser Gly Asn Glu Phe Asn Ile Ser Thr Phe Val Gly 
    130                 135                 140                 
Glu Ser Asn Ser Lys Ser Ile His Thr Ser Pro Ser Ile Glu His Ser 
145                 150                 155                 160 
Ile Lys Val Pro Pro Asn Ser Lys Met Lys Ile Ala Met Ile Gly Thr 
                165                 170                 175     
Leu Ile Thr Glu Val Leu His Phe Gln Ser Ile Ile Thr Val Gln Gly 
            180                 185                 190         
Met Phe Gly Ala Cys Phe Pro Arg Met Val Arg Gly His Tyr Ile Gly 
        195                 200                 205             
Phe Lys Ser Ala Gly His Ile Leu Asn Lys Thr Phe Gly Ile Ile Glu 
    210                 215                 220                 
Gly Ser Ile Asn Asn Thr Ala Ile Gln Asp Ile Glu Ile Asn Ile Lys 
225                 230                 235                 240 
Gly Ile Glu Pro Tyr Ser Tyr Lys Gln Lys Val Ile Lys 
                245                 250             

<210>  7
<211>  762
<212>  DNA
<213>  Bacillus thuringiensis
<220>
<221>  misc_feature
<222>  (1)..(762)
<223>  544s nucleotide sequence

<400>  7
atgattatac aagaaaaatt atctttttca gatttagatt cattaggttc aactacagat       60
tccataatgg acgcgtttaa agatctttat gggctacttc cttatgaaat cgcaataaat      120
aatgagacat ttccaattca taataagcct gctattactg aacgttatgg tcacgcttgt      180
tataaaacgc ttggcccttt tatattcagc aatattgaag agccttcaaa gaatgaagta      240
agcctagggg aacaatttgt atttaatcct agtaatgaag aagcagaaat tatagtcaca      300
ataaaagagc aatgggctaa tattcaatct tggacttcgg aatctactac aggtttaact      360
ttaacatcag attttacgat ggaaggtgaa tttcaattcg gcaacaaatt taatatttca      420
acttttgtgg gagaaagtaa ttcaaaatcc atcattacct ccctttccat tgagcgttct      480
attaaagtac ctccaaatag taagataaaa gttactacag tcggaacatt aattacagaa      540
attctacatt tccaatcaat tatatcggta aacggtatgt ttggtgcatg ttttccacgg      600
atggttcgtg ggcattacgt tggattcaaa agtgccggtc acatcctaaa taaaacattt      660
ggttccatta aaggggccat taatagtaca ataattaagg atattcaaat aaaaactgga      720
aagatagagc cttattttat taaccaaaaa tgggaaagtt ga                         762

<210>  8
<211>  253
<212>  PRT
<213>  Bacillus thuringiensis
<220>
<221>  MISC_FEATURE
<222>  (1)..(253)
<223>  544s

<400>  8
Met Ile Ile Gln Glu Lys Leu Ser Phe Ser Asp Leu Asp Ser Leu Gly 
1               5                   10                  15      
Ser Thr Thr Asp Ser Ile Met Asp Ala Phe Lys Asp Leu Tyr Gly Leu 
            20                  25                  30          
Leu Pro Tyr Glu Ile Ala Ile Asn Asn Glu Thr Phe Pro Ile His Asn 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Arg Tyr Gly His Ala Cys Tyr Lys Thr Leu 
    50                  55                  60                  
Gly Pro Phe Ile Phe Ser Asn Ile Glu Glu Pro Ser Lys Asn Glu Val 
65                  70                  75                  80  
Ser Leu Gly Glu Gln Phe Val Phe Asn Pro Ser Asn Glu Glu Ala Glu 
                85                  90                  95      
Ile Ile Val Thr Ile Lys Glu Gln Trp Ala Asn Ile Gln Ser Trp Thr 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Leu Thr Ser Asp Phe Thr Met Glu 
        115                 120                 125             
Gly Glu Phe Gln Phe Gly Asn Lys Phe Asn Ile Ser Thr Phe Val Gly 
    130                 135                 140                 
Glu Ser Asn Ser Lys Ser Ile Ile Thr Ser Leu Ser Ile Glu Arg Ser 
145                 150                 155                 160 
Ile Lys Val Pro Pro Asn Ser Lys Ile Lys Val Thr Thr Val Gly Thr 
                165                 170                 175     
Leu Ile Thr Glu Ile Leu His Phe Gln Ser Ile Ile Ser Val Asn Gly 
            180                 185                 190         
Met Phe Gly Ala Cys Phe Pro Arg Met Val Arg Gly His Tyr Val Gly 
        195                 200                 205             
Phe Lys Ser Ala Gly His Ile Leu Asn Lys Thr Phe Gly Ser Ile Lys 
    210                 215                 220                 
Gly Ala Ile Asn Ser Thr Ile Ile Lys Asp Ile Gln Ile Lys Thr Gly 
225                 230                 235                 240 
Lys Ile Glu Pro Tyr Phe Ile Asn Gln Lys Trp Glu Ser 
                245                 250             

<210>  9
<211>  1016
<212>  DNA
<213>  Bacillus thuringiensis
<220>
<221>  misc_feature
<222>  (1)..(1016)
<223>  Cry46Aa nucleotide sequence

<400>  9
atgtataatg ataaaagaat gtgttctgat ccttatcagg gtatgaataa acctcattat       60
tgcaattgtc atacgtataa taatagtgaa ataaccggag ggcttcaagt agatctagat      120
aatcaagtag tggaaacatt tcaatccact acagacgtta ttcgagaata tcttatgttt      180
aatgagttat cagcattaag ttcaagtcca gaaagtgtaa gatctagatt ttcctctatt      240
tatggtacta atcccgatgg tattgcatta aataatgaaa cgtattttaa cgccgtaaaa      300
ccgcctatta ctgctcaata tggatactat tgctataaaa atgttgggac tgttcagtac      360
gtaaatagac ctactgatat taacccaaac gttattcttg ctcaagacac attaacaaat      420
aatactaatg aaccatttac tacaactatc actataactg ggtcttttac caacacgtct      480
actgtgacat ctagtacaac aacaggcttt aaatttacta gtaaactatc aattaaaaaa      540
gtctttgaaa ttggtggaga agtttcattc tctactacaa ttggaacatc tgaaacaact      600
acagaaacaa ttactgtatc taaatccgtt acggttacgg tccagctcaa agtagaagaa      660
ctattcagtt aacagctaaa atagcaaaag aatctgcaga ctttagtgct cctattactg      720
tcgatggtta ttttggtgct aattttccca aaagagtagg gccaggtggg cattattttt      780
ggtttaaccc cgctagggat gttctaaata ctacctctgg tacacttaga ggtacagtga      840
cgaatgtatc tagttttgac ttccaaacta tagtgcaacc agcacgcagt ttactagatg      900
aacaacaaga aactttagaa tatgccatac ctggagatcc ttctggggaa caattgcagc      960
aaatggaaca aaggatgttt ttttccaaat gccaatgccc aaaatggggg aattag         1016

<210>  10
<211>  338
<212>  PRT
<213>  Bacillus thuringiensis
<220>
<221>  MISC_FEATURE
<222>  (1)..(338)
<223>  Cry46Aa

<400>  10
Met Tyr Asn Asp Lys Arg Met Cys Ser Asp Pro Tyr Gln Gly Met Asn 
1               5                   10                  15      
Lys Pro His Tyr Cys Asn Cys His Thr Tyr Asn Asn Ser Glu Ile Thr 
            20                  25                  30          
Gly Gly Leu Gln Val Asp Leu Asp Asn Gln Val Val Glu Thr Phe Gln 
        35                  40                  45              
Ser Thr Thr Asp Val Ile Arg Glu Tyr Leu Met Phe Asn Glu Leu Ser 
    50                  55                  60                  
Ala Leu Ser Ser Ser Pro Glu Ser Val Arg Ser Arg Phe Ser Ser Ile 
65                  70                  75                  80  
Tyr Gly Thr Asn Pro Asp Gly Ile Ala Leu Asn Asn Glu Thr Tyr Phe 
                85                  90                  95      
Asn Ala Val Lys Pro Pro Ile Thr Ala Gln Tyr Gly Tyr Tyr Cys Tyr 
            100                 105                 110         
Lys Asn Val Gly Thr Val Gln Tyr Val Asn Arg Pro Thr Asp Ile Asn 
        115                 120                 125             
Pro Asn Val Ile Leu Ala Gln Asp Thr Leu Thr Asn Asn Thr Asn Glu 
    130                 135                 140                 
Pro Phe Thr Thr Thr Ile Thr Ile Thr Gly Ser Phe Thr Asn Thr Ser 
145                 150                 155                 160 
Thr Val Thr Ser Ser Thr Thr Thr Gly Phe Lys Phe Thr Ser Lys Leu 
                165                 170                 175     
Ser Ile Lys Lys Val Phe Glu Ile Gly Gly Glu Val Ser Phe Ser Thr 
            180                 185                 190         
Thr Ile Gly Thr Ser Glu Thr Thr Thr Glu Thr Ile Thr Val Ser Lys 
        195                 200                 205             
Ser Val Thr Val Thr Val Pro Ala Gln Ser Arg Arg Thr Ile Gln Leu 
    210                 215                 220                 
Thr Ala Lys Ile Ala Lys Glu Ser Ala Asp Phe Ser Ala Pro Ile Thr 
225                 230                 235                 240 
Val Asp Gly Tyr Phe Gly Ala Asn Phe Pro Lys Arg Val Gly Pro Gly 
                245                 250                 255     
Gly His Tyr Phe Trp Phe Asn Pro Ala Arg Asp Val Leu Asn Thr Thr 
            260                 265                 270         
Ser Gly Thr Leu Arg Gly Thr Val Thr Asn Val Ser Ser Phe Asp Phe 
        275                 280                 285             
Gln Thr Ile Val Gln Pro Ala Arg Ser Leu Leu Asp Glu Gln Gln Glu 
    290                 295                 300                 
Thr Leu Glu Tyr Ala Ile Pro Gly Asp Pro Ser Gly Glu Gln Leu Gln 
305                 310                 315                 320 
Gln Met Glu Gln Arg Met Phe Phe Ser Lys Cys Gln Cys Pro Lys Trp 
                325                 330                 335     
Gly Asn 
        

<210>  11
<211>  915
<212>  DNA
<213>  Bacillus thuringiensis
<220>
<221>  misc_feature
<222>  (1)..(915)
<223>  Cry46Ab nucleotide sequence

<400>  11
atgtattata ctacccaagt aacaggtgga tttcaagctg atttgaataa tcaagtagtg       60
gaaacatttc aaccaagtac aaatgttatt caagaatacc ttacgtttaa tgacttacca      120
gcattaggtt caagtccaca aagtgtacgc tctagatttt catctattta tggtaccaat      180
ccagatggta ttgcattaaa taatgaaaca tattttagcg ctgtacaacc accaattact      240
gttcaatatg gacactattg ttataaaaat gttgggactg ttcagtacgt aaatagaccc      300
actgatatta acccaaacgt tattctcgct caagacacat taacaaacaa tactaatgag      360
ccatttacta cgaccataac tttaacagga tcttggacca aatcatccac ggttacatct      420
agtacaacaa caggtcttaa aattaccact aaactatcga ttaaaaaagt ctttgaaatt      480
ggtggagaag tttcattctc tactacaatt ggatcatctg aagcaacttc agaaacattt      540
actgtatcga aagccgtgac ggtcacagtt ccagctcaaa gtagaaggaa tattcaatta      600
acagcaaaaa tagcaagaga atctgcagat tttagtgctc ctattactgt ggatggttac      660
tttggtgcta attttcctcg tcgagtaggt ccggggggac attacttttg gtttaatcct      720
gctagagatg ttttaaatgc tacctccggt acactaagag gtaccgtgac gaatgtatct      780
agtttcgact tccaaactgt agtacaacca gcatatagtt tactggctga acagcaagaa      840
gctttagaat ctgccatatc tggagatcct tctgaggaac aattgaaaca aatacaacaa      900
acaattggat tataa                                                       915

<210>  12
<211>  304
<212>  PRT
<213>  Bacillus thuringiensis
<220>
<221>  MISC_FEATURE
<222>  (1)..(304)
<223>  Cry46Ab

<400>  12
Met Tyr Tyr Thr Thr Gln Val Thr Gly Gly Phe Gln Ala Asp Leu Asn 
1               5                   10                  15      
Asn Gln Val Val Glu Thr Phe Gln Pro Ser Thr Asn Val Ile Gln Glu 
            20                  25                  30          
Tyr Leu Thr Phe Asn Asp Leu Pro Ala Leu Gly Ser Ser Pro Gln Ser 
        35                  40                  45              
Val Arg Ser Arg Phe Ser Ser Ile Tyr Gly Thr Asn Pro Asp Gly Ile 
    50                  55                  60                  
Ala Leu Asn Asn Glu Thr Tyr Phe Ser Ala Val Gln Pro Pro Ile Thr 
65                  70                  75                  80  
Val Gln Tyr Gly His Tyr Cys Tyr Lys Asn Val Gly Thr Val Gln Tyr 
                85                  90                  95      
Val Asn Arg Pro Thr Asp Ile Asn Pro Asn Val Ile Leu Ala Gln Asp 
            100                 105                 110         
Thr Leu Thr Asn Asn Thr Asn Glu Pro Phe Thr Thr Thr Ile Thr Leu 
        115                 120                 125             
Thr Gly Ser Trp Thr Lys Ser Ser Thr Val Thr Ser Ser Thr Thr Thr 
    130                 135                 140                 
Gly Leu Lys Ile Thr Thr Lys Leu Ser Ile Lys Lys Val Phe Glu Ile 
145                 150                 155                 160 
Gly Gly Glu Val Ser Phe Ser Thr Thr Ile Gly Ser Ser Glu Ala Thr 
                165                 170                 175     
Ser Glu Thr Phe Thr Val Ser Lys Ala Val Thr Val Thr Val Pro Ala 
            180                 185                 190         
Gln Ser Arg Arg Asn Ile Gln Leu Thr Ala Lys Ile Ala Arg Glu Ser 
        195                 200                 205             
Ala Asp Phe Ser Ala Pro Ile Thr Val Asp Gly Tyr Phe Gly Ala Asn 
    210                 215                 220                 
Phe Pro Arg Arg Val Gly Pro Gly Gly His Tyr Phe Trp Phe Asn Pro 
225                 230                 235                 240 
Ala Arg Asp Val Leu Asn Ala Thr Ser Gly Thr Leu Arg Gly Thr Val 
                245                 250                 255     
Thr Asn Val Ser Ser Phe Asp Phe Gln Thr Val Val Gln Pro Ala Tyr 
            260                 265                 270         
Ser Leu Leu Ala Glu Gln Gln Glu Ala Leu Glu Ser Ala Ile Ser Gly 
        275                 280                 285             
Asp Pro Ser Glu Glu Gln Leu Lys Gln Ile Gln Gln Thr Ile Gly Leu 
    290                 295                 300                 

<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  hydrophobic patch motif
<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  hydrophobic patch motif

<400>  13
His Tyr Phe Trp Phe 
1               5   

<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 beta hairpin region

<400>  14
Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu Gly Phe Phe 
1               5                   10                  15      
Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
            20                  25                  

<210>  15
<211>  29
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  Parasporin-2 beta hairpin region

<400>  15
Thr Thr Gly Phe Lys Phe Thr Ser Lys Leu Ser Ile Lys Lys Val Phe 
1               5                   10                  15      
Glu Ile Gly Gly Glu Val Ser Phe Ser Thr Thr Ile Gly 
            20                  25                  

<210>  16
<211>  29
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  Hydralysin beta hairpin region

<400>  16
Glu Thr Gly Val Lys Met Ser Ser Glu Phe Gly Val Glu Gly Ala Phe 
1               5                   10                  15      
Lys Met Gly Gly Glu Phe Ser Leu Thr Val Ser Gly Val 
            20                  25                  

<210>  17
<211>  29
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  Alpha-Toxin beta hairpin region

<400>  17
Lys Ile Gly Val Lys Thr Ser Phe Lys Val Gly Leu Glu Ala Ile Ala 
1               5                   10                  15      
Asp Ser Lys Val Glu Thr Ser Phe Glu Phe Asn Ala Glu 
            20                  25                  

<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  Aerolysin Beta hairpin region

<400>  18
Lys Val Thr Thr Lys Asn Lys Phe Lys Trp Pro Leu Val Gly Glu Thr 
1               5                   10                  15      
Glu Leu Ser Ile Glu Ile Ala Ala Asn Gln Ser Trp Ala 
            20                  25                  

<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  epislon-toxin beta hairpin region

<400>  19
Ser Ile Gln Ala Thr Ala Lys Phe Thr Val Pro Phe Asn Glu Thr Gly 
1               5                   10                  15      
Val Ser Leu Thr Thr Ser Tyr Ser Phe Ala Asn Thr Asn Thr 
            20                  25                  30  

<210>  20
<211>  31
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  Hemolytic beta hairpin region

<400>  20
Ala Val Gly Thr Ala Phe Lys Ala Gly Val Pro Ile Phe Ala Glu Thr 
1               5                   10                  15      
Glu Phe Lys Val Asp Ile Ser Val Asp Asn Gln Trp Asn Trp Gly 
            20                  25                  30      

<210>  21
<211>  32
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  Enterotoxin beta hairpin region

<400>  21
Glu Val Ser Ile Asn Val Asn Phe Ser Val Gly Phe Thr Ser Glu Phe 
1               5                   10                  15      
Ile Gln Ala Ser Val Glu Tyr Gly Phe Gly Ile Thr Ile Gly Glu Gln 
            20                  25                  30          

<210>  22
<211>  31
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  Alpha-hemolysin beta hairpin region

<400>  22
Thr Leu Thr Tyr Gly Phe Asn Gly Asn Val Thr Gly Asp Asp Thr Gly 
1               5                   10                  15      
Lys Ile Gly Gly Leu Ile Gly Ala Asn Val Ser Ile Gly His Thr 
            20                  25                  30      

<210>  23
<211>  867
<212>  DNA
<213>  Bacillus thuringiensis

<400>  23
atggctatta gtatcgcgat caatgctggg caatcttcat ccgcgtcaac cgtcattgcc       60
acgggcacgg tccagaacgt tatcaccgac accgaacgaa ccttgttcaa catccaggat      120
gggtcgttga aagcggcggt gtctgcctat tttggccgct cgcccaatga cgcttacgtt      180
tgcagcccca cgccctgggg tgatctgtac cagacctaca actggccgca ggtacaagcc      240
acgctgtcgg tggtgagcgc aaggattgtc tcggaaacct cgaacccgat tgccctcaat      300
accaatacct tcaccaatca ctcctcggtg ccggcggagt tcaactgcgg ggtcacccag      360
gaggtgacgg tcaccgcgga aagcaactgg tcgagctcgt cggaagtcgg catcagccag      420
acgatttcct acgggatctc gttcctcggc gccggcgccc agggcgaaac cgccttgagt      480
ttcacccaga cctgggagca gggcggttcg caaagtgagt cggtaaccct gggttcgagc      540
gccggagtga ccctgacctt gcaacccggg cagaccgtag aggcgatact gtcggccagc      600
aagggggtac tgacggtaga agttgagtat caaataaccc tggcgggggt aacggcggtc      660
aattacaacc cgacgtatca ggggcatcac ttctgggcac tggatatcaa caacgtcatg      720
agtgccggca aactgtcgaa tgtcatcacc agcaaagaaa ccatcgtgat cgactacttc      780
accaatacca cgatcaccgt gcaggaccct gaaagccagg atgtcatccg caccctcgtc      840
acctcggcca ggccgggcat cagttca                                          867

<210>  24
<211>  289
<212>  PRT
<213>  Bacillus thuringiensis

<400>  24
Met Ala Ile Ser Ile Ala Ile Asn Ala Gly Gln Ser Ser Ser Ala Ser 
1               5                   10                  15      
Thr Val Ile Ala Thr Gly Thr Val Gln Asn Val Ile Thr Asp Thr Glu 
            20                  25                  30          
Arg Thr Leu Phe Asn Ile Gln Asp Gly Ser Leu Lys Ala Ala Val Ser 
        35                  40                  45              
Ala Tyr Phe Gly Arg Ser Pro Asn Asp Ala Tyr Val Cys Ser Pro Thr 
    50                  55                  60                  
Pro Trp Gly Asp Leu Tyr Gln Thr Tyr Asn Trp Pro Gln Val Gln Ala 
65                  70                  75                  80  
Thr Leu Ser Val Val Ser Ala Arg Ile Val Ser Glu Thr Ser Asn Pro 
                85                  90                  95      
Ile Ala Leu Asn Thr Asn Thr Phe Thr Asn His Ser Ser Val Pro Ala 
            100                 105                 110         
Glu Phe Asn Cys Gly Val Thr Gln Glu Val Thr Val Thr Ala Glu Ser 
        115                 120                 125             
Asn Trp Ser Ser Ser Ser Glu Val Gly Ile Ser Gln Thr Ile Ser Tyr 
    130                 135                 140                 
Gly Ile Ser Phe Leu Gly Ala Gly Ala Gln Gly Glu Thr Ala Leu Ser 
145                 150                 155                 160 
Phe Thr Gln Thr Trp Glu Gln Gly Gly Ser Gln Ser Glu Ser Val Thr 
                165                 170                 175     
Leu Gly Ser Ser Ala Gly Val Thr Leu Thr Leu Gln Pro Gly Gln Thr 
            180                 185                 190         
Val Glu Ala Ile Leu Ser Ala Ser Lys Gly Val Leu Thr Val Glu Val 
        195                 200                 205             
Glu Tyr Gln Ile Thr Leu Ala Gly Val Thr Ala Val Asn Tyr Asn Pro 
    210                 215                 220                 
Thr Tyr Gln Gly His His Phe Trp Ala Leu Asp Ile Asn Asn Val Met 
225                 230                 235                 240 
Ser Ala Gly Lys Leu Ser Asn Val Ile Thr Ser Lys Glu Thr Ile Val 
                245                 250                 255     
Ile Asp Tyr Phe Thr Asn Thr Thr Ile Thr Val Gln Asp Pro Glu Ser 
            260                 265                 270         
Gln Asp Val Ile Arg Thr Leu Val Thr Ser Ala Arg Pro Gly Ile Ser 
        275                 280                 285             
Ser 
    

<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  1' beta turn motif
<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position  2 is Tyr, Asn, His, Ile, Leu, Met or Trp
<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position  4 is Trp, Gln, Glu, His, Ile, Leu, Met, Val, 
       Phe, Ser, Thr or Tyr

<400>  25
His Xaa Phe Xaa Phe 
1               5   

<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  hemolytic reduction motif
<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Tyr or Ala
<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Phe or Ala
<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Trp, Ala, Arg, Asn, Asp, Cys, Gln, Glu, Gly,
       His, Ile, Leu, Lys, Met, Phe, Ser, Thr or Val
<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is Phe or Ala

<400>  26
Xaa Xaa Xaa Xaa 
1               

<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  hemolytic reduction motif 2
<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Tyr or Ala
<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Phe or Ala
<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position  3 is Trp, Gln, Glu, His, Ile, Leu, Met, Val, 
       Phe, Ser, or Thr
<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position  4 is Phe or Ala

<400>  27
Xaa Xaa Xaa Xaa 
1               

<210>  28
<211>  774
<212>  DNA
<213>  Artificial Sequence
<220>
<223>  maize optimized codons

<400>  28
atgaccatcc aggagaagct gtccttcacc gacctgcccg ccctcaagtc ctctcccgag       60
tccgtgcgcc aagccttcac caacaagttc ggcaccaagc ccgacggcat ctccgtcaac      120
tccgagacct acttcaatgc cgtgaagccc gccatcaccg agcagtacgg ccacccatgc      180
tacaagcgcc tgggcgactt caactacatg aagggcgacg gcaagcctcc cacctccgcc      240
atcgtcggct ccaatgtcgc cgtgaactac ggcgatgagg aggccaccat gaccctcgag      300
gtccagggct cttggcagtc cgagcagtcc tggagctccg agtccaccac cggactcacc      360
atctcctcca agttcaccat cgagggcttc ttcgagtccg gcatggagtt cagcgtctcc      420
accaccgtcg gcgagaccaa gaccgagtcc gagtcacgca ccgccaccgc ctccgtgcaa      480
gtgaccgtgc cacccaggtc caagaagcag gtgacgatgg tcggcaccct caagaaggag      540
tccatgaact tccgcgcacc catatccgtc gacgggatgt tcggcgccaa ctttcccaag      600
cgcgtgcagg accactactt ctggttcctg ggcgcagggt ccgtgctcac ccagaccacc      660
ggcgagatca ccggcaccat caagaacacc gccgtgttcg acgtccacac cgagatcggg      720
aagaccgagc ctctgaccgc cgaggagctt tccaagctgg ccgtcctcgc caag            774

<210>  29
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  29
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Ala 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  30
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  30
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Ala His Tyr Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  31
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  31
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp Ala Tyr Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  32
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  32
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Ala Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  33
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  33
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Ala Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  34
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  34
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Trp 
        195                 200                 205             
Ala Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  35
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  35
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Ala Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  36
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  36
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly Ala Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  37
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  37
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Arg 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  38
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  38
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Asn 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  39
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  39
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Asp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  40
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  40
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Cys 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  41
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  41
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Gln 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  42
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  42
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Glu 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  43
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  43
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Gly 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  44
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  44
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe His 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  45
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  45
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Ile 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  46
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  46
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Leu 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  47
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  47
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Lys 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  48
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  48
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Met 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  49
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  49
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Phe 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  50
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  50
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Ser 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  51
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  51
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Thr 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  52
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  52
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Tyr 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  53
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  53
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Tyr Phe Val 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  54
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  54
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Asn Phe Met 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  55
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  55
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Phe Phe Met 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  56
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  56
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Trp Phe Met 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  57
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  57
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Arg Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  58
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  58
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Asn Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  59
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  59
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Asp Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  60
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  60
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Gln Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  61
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  61
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His His Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  62
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  62
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Ile Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  63
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  63
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Leu Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  64
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  64
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Met Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  65
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  65
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Phe Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  66
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  66
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Ser Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  67
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  67
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Thr Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  68
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  68
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Trp Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

<210>  69
<211>  258
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  MP467 variant

<400>  69
Met Thr Ile Gln Glu Lys Leu Ser Phe Thr Asp Leu Pro Ala Leu Lys 
1               5                   10                  15      
Ser Ser Pro Glu Ser Val Arg Gln Ala Phe Thr Asn Lys Phe Gly Thr 
            20                  25                  30          
Lys Pro Asp Gly Ile Ser Val Asn Ser Glu Thr Tyr Phe Asn Ala Val 
        35                  40                  45              
Lys Pro Ala Ile Thr Glu Gln Tyr Gly His Pro Cys Tyr Lys Arg Leu 
    50                  55                  60                  
Gly Asp Phe Asn Tyr Met Lys Gly Asp Gly Lys Pro Pro Thr Ser Ala 
65                  70                  75                  80  
Ile Val Gly Ser Asn Val Ala Val Asn Tyr Gly Asp Glu Glu Ala Thr 
                85                  90                  95      
Met Thr Leu Glu Val Gln Gly Ser Trp Gln Ser Glu Gln Ser Trp Ser 
            100                 105                 110         
Ser Glu Ser Thr Thr Gly Leu Thr Ile Ser Ser Lys Phe Thr Ile Glu 
        115                 120                 125             
Gly Phe Phe Glu Ser Gly Met Glu Phe Ser Val Ser Thr Thr Val Gly 
    130                 135                 140                 
Glu Thr Lys Thr Glu Ser Glu Ser Arg Thr Ala Thr Ala Ser Val Gln 
145                 150                 155                 160 
Val Thr Val Pro Pro Arg Ser Lys Lys Gln Val Thr Met Val Gly Thr 
                165                 170                 175     
Leu Lys Lys Glu Ser Met Asn Phe Arg Ala Pro Ile Ser Val Asp Gly 
            180                 185                 190         
Met Phe Gly Ala Asn Phe Pro Lys Arg Val Gln Asp His Val Phe Trp 
        195                 200                 205             
Phe Leu Gly Ala Gly Ser Val Leu Thr Gln Thr Thr Gly Glu Ile Thr 
    210                 215                 220                 
Gly Thr Ile Lys Asn Thr Ala Val Phe Asp Val His Thr Glu Ile Gly 
225                 230                 235                 240 
Lys Thr Glu Pro Leu Thr Ala Glu Glu Leu Ser Lys Leu Ala Val Leu 
                245                 250                 255     
Ala Lys 
        

