                         SEQUENCE LISTING

<110>  ONCOMED PHARMACEUTICALS, INC.
       GURNEY, AUSTIN L.
       XIE, MING-HONG
       BOND, CHIRSTOPHER JOHN
 
<120>  MET-BINDING AGENTS AND USES THEREOF

<130>  2293.107PC03

<150>  US 61/783,552
<151>  2013-03-14

<150>  US 61/829,477
<151>  2013-05-31

<150>  US 61/898,851
<151>  2013-11-01

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Heavy chain CDR1

<400>  1

Ala Ser Tyr Ala Trp Ser 
1               5       


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Heavy chain CDR2

<400>  2

Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Heavy chain CDR3

<400>  3

Lys Gly Ala Tyr 
1               


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Light chain CDR1

<400>  4

Ser Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu Tyr 
1               5                   10          


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Light chain CDR2

<400>  5

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Light chain CDR3

<400>  6

His Gln Trp Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  7
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Heavy chain variable region amino acid sequence

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Light chain variable region amino acid sequence

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  9
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Heavy chain amino acid sequence with predicted signal 
       sequence

<400>  9

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Thr Thr Ile 
        35                  40                  45              


Thr Ala Ser Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Phe Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
        195                 200                 205             


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  10
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 (13A variant) Heavy chain amino acid sequence with 
       predicted signal sequence

<400>  10

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Thr Thr Ile 
        35                  40                  45              


Thr Ala Ser Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Phe Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
        195                 200                 205             


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Lys 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Lys Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  11
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Light chain amino acid sequence with predicted signal 
       sequence

<400>  11

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              


Ser Ser Ser Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Trp Ser 
            100                 105                 110         


Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  12
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Heavy chain amino acid sequence without predicted signal 
       sequence

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  13
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 (13A variant) Heavy chain amino acid sequence without 
       predicted signal sequence

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Met Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  14
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 Light chain amino acid sequence without predicted signal 
       sequence

<400>  14

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  15
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R009 Heavy chain nucleotide sequence


<220>
<221>  misc_feature
<222>  (1104)..(1104)
<223>  R = A or G

<220>
<221>  misc_feature
<222>  (1230)..(1230)
<223>  Y = C or T

<400>  15
atgaagcatc tgtggttttt cctgctgctc gtggctgctc cccggtgggt cctgtctcag       60

gtccaattgc aagagtcagg accagggctt gtgaagccct cagagactct gtcactcact      120

tgtaccgtga ccggaactac catcactgcc tcctacgcct ggagctggat caggcagcct      180

ccgggaaaag gcctggaatg gatgggttac atctcctatt caggcggaac cgactacaat      240

cctagcctga agtctcgcat caccatttca cgcgatacct tcaagaacca attcagcctt      300

aaactctcca gcgtgaccgc tgcagacact gccacctact actgcgcaag aaagggagcc      360

tattggggtc aggggaccct tgtgaccgtg agctcagcct ctaccaaggg ccctagcgtc      420

ttccctctgg ccccctgctc ccggtccacc agcgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga acctgtgaca gtgtcctgga actccggcgc tctgaccagc      540

ggcgtgcaca ccttcccagc tgtcctccag tcctccggac tctactccct ctcctccgtg      600

gtgacagtgc cctcctccaa cttcggcacc cagacctaca cctgcaacgt cgatcacaag      660

cccagcaaca ccaaggttga taagacagtt gagcgcaaat gttgtgtcga gtgccctcct      720

tgcccagccc ctcctgtggc tggaccttcc gtcttcctct tcccccctaa acccaaagac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccccgagg tccagttcaa ctggtatgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccacggg aggagcagtt caacagcaca ttccgggtgg tcagcgtcct caccgttgtg      960

caccaggact ggctgaacgg caaggagtac aagtgcaaag tctccaacaa aggcctccct     1020

gcccccatcg agaaaaccat ctccaaaacc aaagggcagc ccagggaacc acaggtgtac     1080

accctgcccc cttcccggga ggaratgacc aagaaccaag tcagcctgac ctgcctggtc     1140

aaaggcttct acccctccga catcgccgtg gagtgggaga gcaatgggca gcctgagaac     1200

aactacaaga ccacacctcc catgctggay tccgacggct ccttcttcct ctactccaaa     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcctgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacacagaag tccctctccc tgtctcctgg aaaa           1374


<210>  16
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R009 (13A variant) Heavy chain nucleotide sequence

<400>  16
atgaagcatc tgtggttttt cctgctgctc gtggctgctc cccggtgggt cctgtctcag       60

gtccaattgc aagagtcagg accagggctt gtgaagccct cagagactct gtcactcact      120

tgtaccgtga ccggaactac catcactgcc tcctacgcct ggagctggat caggcagcct      180

ccgggaaaag gcctggaatg gatgggttac atctcctatt caggcggaac cgactacaat      240

cctagcctga agtctcgcat caccatttca cgcgatacct tcaagaacca attcagcctt      300

aaactctcca gcgtgaccgc tgcagacact gccacctact actgcgcaag aaagggagcc      360

tattggggtc aggggaccct tgtgaccgtg agctcagcct ctaccaaggg ccctagcgtc      420

ttccctctgg ccccctgctc ccggtccacc agcgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga acctgtgaca gtgtcctgga actccggcgc tctgaccagc      540

ggcgtgcaca ccttcccagc tgtcctccag tcctccggac tctactccct ctcctccgtg      600

gtgacagtgc cctcctccaa cttcggcacc cagacctaca cctgcaacgt cgatcacaag      660

cccagcaaca ccaaggttga taagacagtt gagcgcaaat gttgtgtcga gtgccctcct      720

tgcccagccc ctcctgtggc tggaccttcc gtcttcctct tcccccctaa acccaaagac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccccgagg tccagttcaa ctggtatgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccacggg aggagcagtt caacagcaca ttccgggtgg tcagcgtcct caccgttgtg      960

caccaggact ggctgaacgg caaggagtac aagtgcaaag tctccaacaa aggcctccct     1020

gcccccatcg agaaaaccat ctccaaaacc aaagggcagc ccagggaacc acaggtgtac     1080

accctgcccc cttcccggga gaagatgacc aagaaccaag tcagcctgac ctgcctggtc     1140

aaaggcttct acccctccga catcgccgtg gagtgggaga gcaatgggca gcctgagaac     1200

aactacaaga ccacacctcc catgctgaag tccgacggct ccttcttcct ctactccaaa     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcctgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacacagaag tccctctccc tgtctcctgg aaaa           1374


<210>  17
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R009 Heavy chain nucleotide sequence without predicted signal 
       sequence


<220>
<221>  misc_feature
<222>  (1047)..(1047)
<223>  R=A or G

<220>
<221>  misc_feature
<222>  (1173)..(1173)
<223>  Y = C or T

<400>  17
caggtccaat tgcaagagtc aggaccaggg cttgtgaagc cctcagagac tctgtcactc       60

acttgtaccg tgaccggaac taccatcact gcctcctacg cctggagctg gatcaggcag      120

cctccgggaa aaggcctgga atggatgggt tacatctcct attcaggcgg aaccgactac      180

aatcctagcc tgaagtctcg catcaccatt tcacgcgata ccttcaagaa ccaattcagc      240

cttaaactct ccagcgtgac cgctgcagac actgccacct actactgcgc aagaaaggga      300

gcctattggg gtcaggggac ccttgtgacc gtgagctcag cctctaccaa gggccctagc      360

gtcttccctc tggccccctg ctcccggtcc accagcgaga gcacagccgc cctgggctgc      420

ctggtcaagg actacttccc cgaacctgtg acagtgtcct ggaactccgg cgctctgacc      480

agcggcgtgc acaccttccc agctgtcctc cagtcctccg gactctactc cctctcctcc      540

gtggtgacag tgccctcctc caacttcggc acccagacct acacctgcaa cgtcgatcac      600

aagcccagca acaccaaggt tgataagaca gttgagcgca aatgttgtgt cgagtgccct      660

ccttgcccag cccctcctgt ggctggacct tccgtcttcc tcttcccccc taaacccaaa      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccccg aggtccagtt caactggtat gtggacggcg tggaggtgca taatgccaag      840

acaaagccac gggaggagca gttcaacagc acattccggg tggtcagcgt cctcaccgtt      900

gtgcaccagg actggctgaa cggcaaggag tacaagtgca aagtctccaa caaaggcctc      960

cctgccccca tcgagaaaac catctccaaa accaaagggc agcccaggga accacaggtg     1020

tacaccctgc ccccttcccg ggaggaratg accaagaacc aagtcagcct gacctgcctg     1080

gtcaaaggct tctacccctc cgacatcgcc gtggagtggg agagcaatgg gcagcctgag     1140

aacaactaca agaccacacc tcccatgctg gaytccgacg gctccttctt cctctactcc     1200

aaactcaccg tggacaagag caggtggcag caggggaacg tcttctcctg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacacag aagtccctct ccctgtctcc tggaaaa        1317


<210>  18
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R009 (13A variant) Heavy chain nucleotide sequence without 
       predicted signal sequence

<400>  18
caggtccaat tgcaagagtc aggaccaggg cttgtgaagc cctcagagac tctgtcactc       60

acttgtaccg tgaccggaac taccatcact gcctcctacg cctggagctg gatcaggcag      120

cctccgggaa aaggcctgga atggatgggt tacatctcct attcaggcgg aaccgactac      180

aatcctagcc tgaagtctcg catcaccatt tcacgcgata ccttcaagaa ccaattcagc      240

cttaaactct ccagcgtgac cgctgcagac actgccacct actactgcgc aagaaaggga      300

gcctattggg gtcaggggac ccttgtgacc gtgagctcag cctctaccaa gggccctagc      360

gtcttccctc tggccccctg ctcccggtcc accagcgaga gcacagccgc cctgggctgc      420

ctggtcaagg actacttccc cgaacctgtg acagtgtcct ggaactccgg cgctctgacc      480

agcggcgtgc acaccttccc agctgtcctc cagtcctccg gactctactc cctctcctcc      540

gtggtgacag tgccctcctc caacttcggc acccagacct acacctgcaa cgtcgatcac      600

aagcccagca acaccaaggt tgataagaca gttgagcgca aatgttgtgt cgagtgccct      660

ccttgcccag cccctcctgt ggctggacct tccgtcttcc tcttcccccc taaacccaaa      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccccg aggtccagtt caactggtat gtggacggcg tggaggtgca taatgccaag      840

acaaagccac gggaggagca gttcaacagc acattccggg tggtcagcgt cctcaccgtt      900

gtgcaccagg actggctgaa cggcaaggag tacaagtgca aagtctccaa caaaggcctc      960

cctgccccca tcgagaaaac catctccaaa accaaagggc agcccaggga accacaggtg     1020

tacaccctgc ccccttcccg ggagaagatg accaagaacc aagtcagcct gacctgcctg     1080

gtcaaaggct tctacccctc cgacatcgcc gtggagtggg agagcaatgg gcagcctgag     1140

aacaactaca agaccacacc tcccatgctg aagtccgacg gctccttctt cctctactcc     1200

aaactcaccg tggacaagag caggtggcag caggggaacg tcttctcctg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacacag aagtccctct ccctgtctcc tggaaaa        1317


<210>  19
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R009 Light chain nucleotide sequence

<400>  19
atgaagcacc tctggttctt ccttcttctt gtggccgctc cccgctgggt cctcagcgat       60

atcgtgctga cccagtcacc cgccaccctc tcagcttcac ctggcgagaa ggtcactctg      120

acttgctctg cctcatctag cgtgtcatct tcatatctgt actggtatca gcaaaaaccg      180

ggacaagccc cgaagctcct gatctacagc accagcaacc ttgcatccgg agtgcctgcc      240

aggtttagcg ggtccgggtc cggtacctca tattcactga ccatttcttc tcttgaaccc      300

gaagatttcg ctacctacta ctgtcatcag tggtctagct acccatacac tttcggcgga      360

ggaaccaaac tggagattaa gcgtacggtg gcagcccctt ctgtctttat cttccctcca      420

tccgacgagc agctcaaatc aggaaccgct tctgtcgtgt gcctgcttaa caatttctac      480

ccacgggaag ccaaggtgca gtggaaggtg gacaatgccc tgcaatcagg taattcccaa      540

gagtcagtga ctgaacagga tagcaaggac agcacctatt cactctccag cactctgacc      600

ctgtccaagg ctgactacga aaagcataag gtgtacgcat gcgaggtgac ccaccagggt      660

ctgagcagcc ccgtcaccaa gtctttcaac agaggggagt gt                         702


<210>  20
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R009 Light chain nucleotide sequence without predicted signal 
       sequence

<400>  20
gatatcgtgc tgacccagtc acccgccacc ctctcagctt cacctggcga gaaggtcact       60

ctgacttgct ctgcctcatc tagcgtgtca tcttcatatc tgtactggta tcagcaaaaa      120

ccgggacaag ccccgaagct cctgatctac agcaccagca accttgcatc cggagtgcct      180

gccaggttta gcgggtccgg gtccggtacc tcatattcac tgaccatttc ttctcttgaa      240

cccgaagatt tcgctaccta ctactgtcat cagtggtcta gctacccata cactttcggc      300

ggaggaacca aactggagat taagcgtacg gtggcagccc cttctgtctt tatcttccct      360

ccatccgacg agcagctcaa atcaggaacc gcttctgtcg tgtgcctgct taacaatttc      420

tacccacggg aagccaaggt gcagtggaag gtggacaatg ccctgcaatc aggtaattcc      480

caagagtcag tgactgaaca ggatagcaag gacagcacct attcactctc cagcactctg      540

accctgtcca aggctgacta cgaaaagcat aaggtgtacg catgcgaggt gacccaccag      600

ggtctgagca gccccgtcac caagtctttc aacagagggg agtgt                      645


<210>  21
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Gln Pro Pro Pro Pro Pro Gln Gln Gln Gln Ser Gly Gln Gln Tyr 
1               5                   10                  15      


Asn Gly Glu Arg Gly Ile Ser Val Pro Asp His Gly Tyr Cys Gln Pro 
            20                  25                  30          


Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln Thr Ile Met 
        35                  40                  45              


Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly Leu Glu Val 
    50                  55                  60                  


His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Ala Glu Leu Lys 
65                  70                  75                  80  


Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val Leu Glu Gln 
                85                  90                  95      


Ala Leu Pro Pro Cys Arg Ser Leu Cys Glu Arg Ala Arg Gln Gly Cys 
            100                 105                 110         


Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Asp Thr Leu Lys 
        115                 120                 125             


Cys Glu Lys Phe Pro Val His Gly Ala Gly Glu Leu Cys Val Gly Gln 
    130                 135                 140                 


Asn Thr Ser Asp Lys Gly Thr 
145                 150     


<210>  22
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Phe His Gly Glu Lys Gly Ile Ser Ile Pro Asp His Gly Phe Cys 
1               5                   10                  15      


Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln Thr 
            20                  25                  30          


Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly Leu 
        35                  40                  45              


Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Pro Glu 
    50                  55                  60                  


Leu Arg Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val Leu 
65                  70                  75                  80  


Glu Gln Ala Ile Pro Pro Cys Arg Ser Ile Cys Glu Arg Ala Arg Gln 
                85                  90                  95      


Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Glu Arg 
            100                 105                 110         


Leu Arg Cys Glu His Phe Pro Arg His Gly Ala Glu Gln Ile Cys Val 
        115                 120                 125             


Gly Gln Asn His Ser Glu Asp Gly 
    130                 135     


<210>  23
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  23

His Ser Leu Phe Ser Cys Glu Pro Ile Thr Leu Arg Met Cys Gln Asp 
1               5                   10                  15      


Leu Pro Tyr Asn Thr Thr Phe Met Pro Asn Leu Leu Asn His Tyr Asp 
            20                  25                  30          


Gln Gln Thr Ala Ala Leu Ala Met Glu Pro Phe His Pro Met Val Asn 
        35                  40                  45              


Leu Asp Cys Ser Arg Asp Phe Arg Pro Phe Leu Cys Ala Leu Tyr Ala 
    50                  55                  60                  


Pro Ile Cys Met Glu Tyr Gly Arg Val Thr Leu Pro Cys Arg Arg Leu 
65                  70                  75                  80  


Cys Gln Arg Ala Tyr Ser Glu Cys Ser Lys Leu Met Glu Met Phe Gly 
                85                  90                  95      


Val Pro Trp Pro Glu Asp Met Glu Cys Ser Arg Phe Pro Asp Cys Asp 
            100                 105                 110         


Glu Pro Tyr Pro Arg Leu Val Asp Leu 
        115                 120     


<210>  24
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  24

Phe Gly Asp Glu Glu Glu Arg Arg Cys Asp Pro Ile Arg Ile Ser Met 
1               5                   10                  15      


Cys Gln Asn Leu Gly Tyr Asn Val Thr Lys Met Pro Asn Leu Val Gly 
            20                  25                  30          


His Glu Leu Gln Thr Asp Ala Glu Leu Gln Leu Thr Thr Phe Thr Pro 
        35                  40                  45              


Leu Ile Gln Tyr Gly Cys Ser Ser Gln Leu Gln Phe Phe Leu Cys Ser 
    50                  55                  60                  


Val Tyr Val Pro Met Cys Thr Glu Lys Ile Asn Ile Pro Ile Gly Pro 
65                  70                  75                  80  


Cys Gly Gly Met Cys Leu Ser Val Lys Arg Arg Cys Glu Pro Val Leu 
                85                  90                  95      


Lys Glu Phe Gly Phe Ala Trp Pro Glu Ser Leu Asn Cys Ser Lys Phe 
            100                 105                 110         


Pro Pro Gln Asn Asp His Asn His Met Cys Met Glu Gly Pro Gly Asp 
        115                 120                 125             


Glu Glu Val 
    130     


<210>  25
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Ser Lys Ala Pro Val Cys Gln Glu Ile Thr Val Pro Met Cys Arg 
1               5                   10                  15      


Gly Ile Gly Tyr Asn Leu Thr His Met Pro Asn Gln Phe Asn His Asp 
            20                  25                  30          


Thr Gln Asp Glu Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val 
        35                  40                  45              


Glu Ile Gln Cys Ser Pro Asp Leu Arg Phe Phe Leu Cys Ser Met Tyr 
    50                  55                  60                  


Thr Pro Ile Cys Leu Pro Asp Tyr His Lys Pro Leu Pro Pro Cys Arg 
65                  70                  75                  80  


Ser Val Cys Glu Arg Ala Lys Ala Gly Cys Ser Pro Leu Met Arg Gln 
                85                  90                  95      


Tyr Gly Phe Ala Trp Pro Glu Arg Met Ser Cys Asp Arg Leu Pro Val 
            100                 105                 110         


Leu Gly Arg Asp Ala Glu Val Leu Cys Met Asp Tyr Asn Arg Ser Glu 
        115                 120                 125             


Ala Thr Thr 
    130     


<210>  26
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  26

His Ser Leu Phe Thr Cys Glu Pro Ile Thr Val Pro Arg Cys Met Lys 
1               5                   10                  15      


Met Ala Tyr Asn Met Thr Phe Phe Pro Asn Leu Met Gly His Tyr Asp 
            20                  25                  30          


Gln Ser Ile Ala Ala Val Glu Met Glu His Phe Leu Pro Leu Ala Asn 
        35                  40                  45              


Leu Glu Cys Ser Pro Asn Ile Glu Thr Phe Leu Cys Lys Ala Phe Val 
    50                  55                  60                  


Pro Thr Cys Ile Glu Gln Ile His Val Val Pro Pro Cys Arg Lys Leu 
65                  70                  75                  80  


Cys Glu Lys Val Tyr Ser Asp Cys Lys Lys Leu Ile Asp Thr Phe Gly 
                85                  90                  95      


Ile Arg Trp Pro Glu Glu Leu Glu Cys Asp Arg Leu Gln Tyr Cys Asp 
            100                 105                 110         


Glu Thr Val Pro Val Thr Phe Asp Pro His Thr Glu Phe Leu Gly 
        115                 120                 125         


<210>  27
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Pro Tyr His Gly Glu Lys Gly Ile Ser Val Pro Asp His Gly Phe 
1               5                   10                  15      


Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln 
            20                  25                  30          


Thr Ile Leu Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly 
        35                  40                  45              


Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Pro 
    50                  55                  60                  


Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val 
65                  70                  75                  80  


Leu Asp Gln Ala Ile Pro Pro Cys Arg Ser Leu Cys Glu Arg Ala Arg 
                85                  90                  95      


Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Glu 
            100                 105                 110         


Arg Leu Arg Cys Glu Asn Phe Pro Val His Gly Ala Gly Glu Ile Cys 
        115                 120                 125             


Val Gly Gln Asn Thr Ser Asp Gly Ser Gly 
    130                 135             


<210>  28
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Ser Ala Lys Glu Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys 
1               5                   10                  15      


Lys Gly Ile Gly Tyr Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His 
            20                  25                  30          


Asp Thr Gln Asp Glu Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu 
        35                  40                  45              


Val Glu Ile Gln Cys Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met 
    50                  55                  60                  


Tyr Thr Pro Ile Cys Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys 
65                  70                  75                  80  


Arg Ser Val Cys Glu Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg 
                85                  90                  95      


Gln Tyr Gly Phe Ala Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro 
            100                 105                 110         


Glu Gln Gly Asn Pro Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp 
        115                 120                 125             


Leu Thr Thr 
    130     


<210>  29
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Ser Ala Lys Glu Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys 
1               5                   10                  15      


Lys Gly Ile Gly Tyr Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His 
            20                  25                  30          


Asp Thr Gln Asp Glu Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu 
        35                  40                  45              


Val Glu Ile Gln Cys Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met 
    50                  55                  60                  


Tyr Thr Pro Ile Cys Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys 
65                  70                  75                  80  


Arg Ser Val Cys Glu Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg 
                85                  90                  95      


Gln Tyr Gly Phe Ala Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro 
            100                 105                 110         


Glu Gln Gly Asn Pro Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp 
        115                 120                 125             


Leu 
    


<210>  30
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Glu Ile Gly Arg Phe Asp Pro Glu Arg Gly Arg Gly Ala Ala Pro 
1               5                   10                  15      


Cys Gln Ala Val Glu Ile Pro Met Cys Arg Gly Ile Gly Tyr Asn Leu 
            20                  25                  30          


Thr Arg Met Pro Asn Leu Leu Gly His Thr Ser Gln Gly Glu Ala Ala 
        35                  40                  45              


Ala Glu Leu Ala Glu Phe Ala Pro Leu Val Gln Tyr Gly Cys His Ser 
    50                  55                  60                  


His Leu Arg Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr Asp 
65                  70                  75                  80  


Gln Val Ser Thr Pro Ile Pro Ala Cys Arg Pro Met Cys Glu Gln Ala 
                85                  90                  95      


Arg Leu Arg Cys Ala Pro Ile Met Glu Gln Phe Asn Phe Gly Trp Pro 
            100                 105                 110         


Asp Ser Leu Asp Cys Ala Arg Leu Pro Thr Arg Asn Asp Pro His Ala 
        115                 120                 125             


Leu Cys Met Glu Ala Pro Glu Asn Ala 
    130                 135         


<210>  31
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  31

Ile Ser Ser Met Asp Met Glu Arg Pro Gly Asp Gly Lys Cys Gln Pro 
1               5                   10                  15      


Ile Glu Ile Pro Met Cys Lys Asp Ile Gly Tyr Asn Met Thr Arg Met 
            20                  25                  30          


Pro Asn Leu Met Gly His Glu Asn Gln Arg Glu Ala Ala Ile Gln Leu 
        35                  40                  45              


His Glu Phe Ala Pro Leu Val Glu Tyr Gly Cys His Gly His Leu Arg 
    50                  55                  60                  


Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr Glu Gln Val Ser 
65                  70                  75                  80  


Thr Pro Ile Pro Ala Cys Arg Val Met Cys Glu Gln Ala Arg Leu Lys 
                85                  90                  95      


Cys Ser Pro Ile Met Glu Gln Phe Asn Phe Lys Trp Pro Asp Ser Leu 
            100                 105                 110         


Asp Cys Arg Lys Leu Pro Asn Lys Asn Asp Pro Asn Tyr Leu Cys Met 
        115                 120                 125             


Glu Ala Pro Asn Asn Gly 
    130                 


<210>  32
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  32

Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln 
1               5                   10                  15      


Thr Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly 
            20                  25                  30          


Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Ala 
        35                  40                  45              


Glu Leu Lys Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val 
    50                  55                  60                  


Leu Glu Gln Ala Leu Pro Pro Cys Arg Ser Leu Cys Glu Arg Ala Arg 
65                  70                  75                  80  


Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Asp 
                85                  90                  95      


Thr Leu Lys Cys Glu Lys Phe Pro Val His Gly Ala Gly Glu Leu Cys 
            100                 105                 110         


<210>  33
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  33

Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln 
1               5                   10                  15      


Thr Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly 
            20                  25                  30          


Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Pro 
        35                  40                  45              


Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val 
    50                  55                  60                  


Leu Glu Gln Ala Ile Pro Pro Cys Arg Ser Ile Cys Glu Arg Ala Arg 
65                  70                  75                  80  


Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Glu 
                85                  90                  95      


Arg Leu Arg Cys Glu His Phe Pro Arg His Gly Ala Glu Gln Ile Cys 
            100                 105                 110         


<210>  34
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  34

Cys Glu Pro Ile Thr Leu Arg Met Cys Gln Asp Leu Pro Tyr Asn Thr 
1               5                   10                  15      


Thr Phe Met Pro Asn Leu Leu Asn His Tyr Asp Gln Gln Thr Ala Ala 
            20                  25                  30          


Leu Ala Met Glu Pro Phe His Pro Met Val Asn Leu Asp Cys Ser Arg 
        35                  40                  45              


Asp Phe Arg Pro Phe Leu Cys Ala Leu Tyr Ala Pro Ile Cys Met Glu 
    50                  55                  60                  


Tyr Gly Arg Val Thr Leu Pro Cys Arg Arg Leu Cys Gln Arg Ala Tyr 
65                  70                  75                  80  


Ser Glu Cys Ser Lys Leu Met Glu Met Phe Gly Val Pro Trp Pro Glu 
                85                  90                  95      


Asp Met Glu Cys Ser Arg Phe Pro Asp Cys 
            100                 105     


<210>  35
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  35

Cys Asp Pro Ile Arg Ile Ser Met Cys Gln Asn Leu Gly Tyr Asn Val 
1               5                   10                  15      


Thr Lys Met Pro Asn Leu Val Gly His Glu Leu Gln Thr Asp Ala Glu 
            20                  25                  30          


Leu Gln Leu Thr Thr Phe Thr Pro Leu Ile Gln Tyr Gly Cys Ser Ser 
        35                  40                  45              


Gln Leu Gln Phe Phe Leu Cys Ser Val Tyr Val Pro Met Cys Thr Glu 
    50                  55                  60                  


Lys Ile Asn Ile Pro Ile Gly Pro Cys Gly Gly Met Cys Leu Ser Val 
65                  70                  75                  80  


Lys Arg Arg Cys Glu Pro Val Leu Lys Glu Phe Gly Phe Ala Trp Pro 
                85                  90                  95      


Glu Ser Leu Asn Cys Ser Lys Phe Pro Pro Gln Asn Asp His Asn His 
            100                 105                 110         


Met Cys 
        


<210>  36
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  36

Cys Gln Glu Ile Thr Val Pro Met Cys Arg Gly Ile Gly Tyr Asn Leu 
1               5                   10                  15      


Thr His Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu Ala Gly 
            20                  25                  30          


Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys Ser Pro 
        35                  40                  45              


Asp Leu Arg Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys Leu Pro 
    50                  55                  60                  


Asp Tyr His Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu Arg Ala 
65                  70                  75                  80  


Lys Ala Gly Cys Ser Pro Leu Met Arg Gln Tyr Gly Phe Ala Trp Pro 
                85                  90                  95      


Glu Arg Met Ser Cys Asp Arg Leu Pro Val Leu Gly Arg Asp Ala Glu 
            100                 105                 110         


Val Leu Cys 
        115 


<210>  37
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  37

Cys Glu Pro Ile Thr Val Pro Arg Cys Met Lys Met Ala Tyr Asn Met 
1               5                   10                  15      


Thr Phe Phe Pro Asn Leu Met Gly His Tyr Asp Gln Ser Ile Ala Ala 
            20                  25                  30          


Val Glu Met Glu His Phe Leu Pro Leu Ala Asn Leu Glu Cys Ser Pro 
        35                  40                  45              


Asn Ile Glu Thr Phe Leu Cys Lys Ala Phe Val Pro Thr Cys Ile Glu 
    50                  55                  60                  


Gln Ile His Val Val Pro Pro Cys Arg Lys Leu Cys Glu Lys Val Tyr 
65                  70                  75                  80  


Ser Asp Cys Lys Lys Leu Ile Asp Thr Phe Gly Ile Arg Trp Pro Glu 
                85                  90                  95      


Glu Leu Glu Cys Asp Arg Leu Gln Tyr Cys 
            100                 105     


<210>  38
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  38

Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln 
1               5                   10                  15      


Thr Ile Leu Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly 
            20                  25                  30          


Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Pro 
        35                  40                  45              


Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val 
    50                  55                  60                  


Leu Asp Gln Ala Ile Pro Pro Cys Arg Ser Leu Cys Glu Arg Ala Arg 
65                  70                  75                  80  


Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Glu 
                85                  90                  95      


Arg Leu Arg Cys Glu Asn Phe Pro Val His Gly Ala Gly Glu Ile Cys 
            100                 105                 110         


<210>  39
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  39

Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr Asn Tyr 
1               5                   10                  15      


Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu Ala Gly 
            20                  25                  30          


Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys Ser Pro 
        35                  40                  45              


Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys Leu Glu 
    50                  55                  60                  


Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu Arg Ala 
65                  70                  75                  80  


Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala Trp Pro 
                85                  90                  95      


Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro Asp Thr 
            100                 105                 110         


Leu Cys 
        


<210>  40
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  40

Cys Gln Ala Val Glu Ile Pro Met Cys Arg Gly Ile Gly Tyr Asn Leu 
1               5                   10                  15      


Thr Arg Met Pro Asn Leu Leu Gly His Thr Ser Gln Gly Glu Ala Ala 
            20                  25                  30          


Ala Glu Leu Ala Glu Phe Ala Pro Leu Val Gln Tyr Gly Cys His Ser 
        35                  40                  45              


His Leu Arg Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr Asp 
    50                  55                  60                  


Gln Val Ser Thr Pro Ile Pro Ala Cys Arg Pro Met Cys Glu Gln Ala 
65                  70                  75                  80  


Arg Leu Arg Cys Ala Pro Ile Met Glu Gln Phe Asn Phe Gly Trp Pro 
                85                  90                  95      


Asp Ser Leu Asp Cys Ala Arg Leu Pro Thr Arg Asn Asp Pro His Ala 
            100                 105                 110         


Leu Cys 
        


<210>  41
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  41

Cys Gln Pro Ile Glu Ile Pro Met Cys Lys Asp Ile Gly Tyr Asn Met 
1               5                   10                  15      


Thr Arg Met Pro Asn Leu Met Gly His Glu Asn Gln Arg Glu Ala Ala 
            20                  25                  30          


Ile Gln Leu His Glu Phe Ala Pro Leu Val Glu Tyr Gly Cys His Gly 
        35                  40                  45              


His Leu Arg Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr Glu 
    50                  55                  60                  


Gln Val Ser Thr Pro Ile Pro Ala Cys Arg Val Met Cys Glu Gln Ala 
65                  70                  75                  80  


Arg Leu Lys Cys Ser Pro Ile Met Glu Gln Phe Asn Phe Lys Trp Pro 
                85                  90                  95      


Asp Ser Leu Asp Cys Arg Lys Leu Pro Asn Lys Asn Asp Pro Asn Tyr 
            100                 105                 110         


Leu Cys 
        


<210>  42
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  42

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  43
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region variant

<400>  43

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  44
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  44

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  45
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  45

Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  46
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region variant

<400>  46

Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  47
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region (Variant 13A)

<400>  47

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Lys Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Lys 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  48
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region (Variant 13B)

<400>  48

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Glu Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Glu Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  49
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region (Variant 13A)

<400>  49

Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Lys Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Lys Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  50
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region variant (Variant 13A)

<400>  50

Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Lys Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Lys Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  51
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region (Variant 13B)

<400>  51

Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Glu Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  52
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region variant (Variant 13B)

<400>  52

Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Glu Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  53
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD8-Fc variant 54F28 amino acid sequence without predicted 
       signal sequence

<400>  53

Ala Ser Ala Lys Glu Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys 
1               5                   10                  15      


Lys Gly Ile Gly Tyr Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His 
            20                  25                  30          


Asp Thr Gln Asp Glu Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu 
        35                  40                  45              


Val Glu Ile Gln Cys Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met 
    50                  55                  60                  


Tyr Thr Pro Ile Cys Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys 
65                  70                  75                  80  


Arg Ser Val Cys Glu Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg 
                85                  90                  95      


Gln Tyr Gly Phe Ala Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro 
            100                 105                 110         


Glu Gln Gly Asn Pro Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp 
        115                 120                 125             


Leu Thr Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
    130                 135                 140                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
145                 150                 155                 160 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                165                 170                 175     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            180                 185                 190         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        195                 200                 205             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    210                 215                 220                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
225                 230                 235                 240 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                245                 250                 255     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            260                 265                 270         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        275                 280                 285             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    290                 295                 300                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
305                 310                 315                 320 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                325                 330                 335     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            340                 345                 350         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360             


<210>  54
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD8-Fc variant 54F28 amino acid sequence with signal sequence

<400>  54

Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gln Arg Ser Pro Phe Val His Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp Leu Thr Thr Glu Pro 
145                 150                 155                 160 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                165                 170                 175     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            180                 185                 190         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        195                 200                 205             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    210                 215                 220                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
225                 230                 235                 240 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                245                 250                 255     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            260                 265                 270         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        275                 280                 285             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    290                 295                 300                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
305                 310                 315                 320 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                325                 330                 335     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            340                 345                 350         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        355                 360                 365             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    370                 375                 380                 


Ser Leu Ser Pro Gly Lys 
385                 390 


<210>  55
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD8-Fc variant (13B variant) amino acid sequence with signal 
       sequence

<400>  55

Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gln Arg Ser Pro Ile Val His Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp Leu Thr Thr Thr Lys 
145                 150                 155                 160 


Val Asp Lys Thr Val Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys 
                165                 170                 175     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            180                 185                 190         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        195                 200                 205             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    210                 215                 220                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
225                 230                 235                 240 


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
                245                 250                 255     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            260                 265                 270         


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
        275                 280                 285             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    290                 295                 300                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro 
305                 310                 315                 320 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                325                 330                 335     


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            340                 345                 350         


Tyr Ser Glu Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        355                 360                 365             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    370                 375                 380                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390             


<210>  56
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD8-Fc variant (13B variant) amino acid sequence without signal 
       sequence

<400>  56

Ala Ser Ala Lys Glu Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys 
1               5                   10                  15      


Lys Gly Ile Gly Tyr Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His 
            20                  25                  30          


Asp Thr Gln Asp Glu Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu 
        35                  40                  45              


Val Glu Ile Gln Cys Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met 
    50                  55                  60                  


Tyr Thr Pro Ile Cys Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys 
65                  70                  75                  80  


Arg Ser Val Cys Glu Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg 
                85                  90                  95      


Gln Tyr Gly Phe Ala Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro 
            100                 105                 110         


Glu Gln Gly Asn Pro Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp 
        115                 120                 125             


Leu Thr Thr Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser Cys Val 
    130                 135                 140                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
145                 150                 155                 160 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                165                 170                 175     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            180                 185                 190         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        195                 200                 205             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    210                 215                 220                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
225                 230                 235                 240 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                245                 250                 255     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            260                 265                 270         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        275                 280                 285             


Glu Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    290                 295                 300                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
305                 310                 315                 320 


Gly Ser Phe Phe Leu Tyr Ser Glu Leu Thr Val Asp Lys Ser Arg Trp 
                325                 330                 335     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            340                 345                 350         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 365     


<210>  57
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  57

Asp Leu Val Tyr Phe Glu Lys Ser Pro Asn Phe Cys Thr Tyr Ser Gly 
1               5                   10                  15      


Arg Leu Gly Thr Ala Gly Thr Ala Gly Arg Ala Cys Asn Ser Ser Ser 
            20                  25                  30          


Pro Ala Leu Asp Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly His Arg 
        35                  40                  45              


Thr Arg Thr Gln Arg Val Thr Glu Arg Cys Asn Cys Thr Phe His Trp 
    50                  55                  60                  


Cys Cys His Val Ser Cys Arg Asn Cys Thr His Thr Arg Val Leu His 
65                  70                  75                  80  


Glu Cys Leu 
            


<210>  58
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  58

Asp Leu Val Tyr Phe Glu Asn Ser Pro Asp Tyr Cys Ile Arg Asp Arg 
1               5                   10                  15      


Glu Ala Gly Ser Leu Gly Thr Ala Gly Arg Val Cys Asn Leu Thr Ser 
            20                  25                  30          


Arg Gly Met Asp Ser Cys Glu Val Met Cys Cys Gly Arg Gly Tyr Asp 
        35                  40                  45              


Thr Ser His Val Thr Arg Met Thr Lys Cys Gly Cys Lys Phe His Trp 
    50                  55                  60                  


Cys Cys Ala Val Arg Cys Gln Asp Cys Leu Glu Ala Leu Asp Val His 
65                  70                  75                  80  


Thr Cys Lys Ala Pro Lys Asn Ala Asp Trp Thr Thr Ala Thr 
                85                  90                  


<210>  59
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  59

Asp Leu Val Tyr Phe Asp Asn Ser Pro Asp Tyr Cys Val Leu Asp Lys 
1               5                   10                  15      


Ala Ala Gly Ser Leu Gly Thr Ala Gly Arg Val Cys Ser Lys Thr Ser 
            20                  25                  30          


Lys Gly Thr Asp Gly Cys Glu Ile Met Cys Cys Gly Arg Gly Tyr Asp 
        35                  40                  45              


Thr Thr Arg Val Thr Arg Val Thr Gln Cys Glu Cys Lys Phe His Trp 
    50                  55                  60                  


Cys Cys Ala Val Arg Cys Lys Glu Cys Arg Asn Thr Val Asp Val His 
65                  70                  75                  80  


Thr Cys Lys Ala Pro Lys Lys Ala Glu Trp Leu Asp Gln Thr 
                85                  90                  


<210>  60
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  60

Asp Leu Val Tyr Tyr Glu Asn Ser Pro Asn Phe Cys Glu Pro Asn Pro 
1               5                   10                  15      


Glu Thr Gly Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Thr Ser 
            20                  25                  30          


His Gly Ile Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn 
        35                  40                  45              


Thr Arg Thr Glu Lys Arg Lys Glu Lys Cys His Cys Ile Phe His Trp 
    50                  55                  60                  


Cys Cys Tyr Val Ser Cys Gln Glu Cys Ile Arg Ile Tyr Asp Val His 
65                  70                  75                  80  


Thr Cys Lys 
            


<210>  61
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  61

Asp Leu Val Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro 
1               5                   10                  15      


Glu Thr Gly Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser 
            20                  25                  30          


His Gly Ile Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn 
        35                  40                  45              


Ala Arg Ala Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp 
    50                  55                  60                  


Cys Cys Tyr Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His 
65                  70                  75                  80  


Thr Cys Lys 
            


<210>  62
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  62

Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro 
1               5                   10                  15      


Val Thr Gly Ser Val Gly Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala 
            20                  25                  30          


Pro Gln Ala Ser Gly Cys Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn 
        35                  40                  45              


Thr His Gln Tyr Ala Arg Val Trp Gln Cys Asn Cys Lys Phe His Trp 
    50                  55                  60                  


Cys Cys Tyr Val Lys Cys Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr 
65                  70                  75                  80  


Thr Cys Lys 
            


<210>  63
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  63

Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn Tyr Cys Glu Glu Asp Ala 
1               5                   10                  15      


Ala Thr Gly Ser Val Gly Thr Gln Gly Arg Leu Cys Asn Arg Thr Ser 
            20                  25                  30          


Pro Gly Ala Asp Gly Cys Asp Thr Met Cys Cys Gly Arg Gly Tyr Asn 
        35                  40                  45              


Thr His Gln Tyr Thr Lys Val Trp Gln Cys Asn Cys Lys Phe His Trp 
    50                  55                  60                  


Cys Cys Phe Val Lys Cys Asn Thr Cys Ser Glu Arg Thr Glu Val Phe 
65                  70                  75                  80  


Thr Cys Lys 
            


<210>  64
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  64

Glu Leu Ile Phe Leu Glu Glu Ser Pro Asp Tyr Cys Thr Cys Asn Ser 
1               5                   10                  15      


Ser Leu Gly Ile Tyr Gly Thr Glu Gly Arg Glu Cys Leu Gln Asn Ser 
            20                  25                  30          


His Asn Thr Ser Arg Trp Glu Arg Arg Ser Cys Gly Arg Leu Cys Thr 
        35                  40                  45              


Glu Cys Gly Leu Gln Val Glu Glu Arg Lys Thr Glu Val Ile Ser Ser 
    50                  55                  60                  


Cys Asn Cys Lys Phe Gln Trp Cys Cys Thr Val Lys Cys Asp Gln Cys 
65                  70                  75                  80  


Arg His Val Val Ser Lys Tyr Tyr Cys Ala Arg Ser Pro Gly Ser Ala 
                85                  90                  95      


Gln Ser Leu Gly Arg Val Trp Phe Gly Val Tyr Ile 
            100                 105             


<210>  65
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Leu Val His Leu Glu Asp Ser Pro Asp Tyr Cys Leu Glu Asn Lys 
1               5                   10                  15      


Thr Leu Gly Leu Leu Gly Thr Glu Gly Arg Glu Cys Leu Arg Arg Gly 
            20                  25                  30          


Arg Ala Leu Gly Arg Trp Glu Leu Arg Ser Cys Arg Arg Leu Cys Gly 
        35                  40                  45              


Asp Cys Gly Leu Ala Val Glu Glu Arg Arg Ala Glu Thr Val Ser Ser 
    50                  55                  60                  


Cys Asn Cys Lys Phe His Trp Cys Cys Ala Val Arg Cys Glu Gln Cys 
65                  70                  75                  80  


Arg Arg Arg Val Thr Lys Tyr Phe Cys Ser Arg Ala Glu Arg Pro Arg 
                85                  90                  95      


Gly Gly Ala Ala His Lys Pro Gly Arg Lys Pro 
            100                 105         


<210>  66
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  66

Asp Leu Val Tyr Phe Glu Lys Ser Pro Asp Phe Cys Glu Arg Glu Pro 
1               5                   10                  15      


Arg Leu Asp Ser Ala Gly Thr Val Gly Arg Leu Cys Asn Lys Ser Ser 
            20                  25                  30          


Ala Gly Ser Asp Gly Cys Gly Ser Met Cys Cys Gly Arg Gly His Asn 
        35                  40                  45              


Ile Leu Arg Gln Thr Arg Ser Glu Arg Cys His Cys Arg Phe His Trp 
    50                  55                  60                  


Cys Cys Phe Val Val Cys Glu Glu Cys Arg Ile Thr Glu Trp Val Ser 
65                  70                  75                  80  


Val Cys Lys 
            


<210>  67
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  67

Glu Leu Val Tyr Phe Glu Lys Ser Pro Asp Phe Cys Glu Arg Asp Pro 
1               5                   10                  15      


Thr Met Gly Ser Pro Gly Thr Arg Gly Arg Ala Cys Asn Lys Thr Ser 
            20                  25                  30          


Arg Leu Leu Asp Gly Cys Gly Ser Leu Cys Cys Gly Arg Gly His Asn 
        35                  40                  45              


Val Leu Arg Gln Thr Arg Val Glu Arg Cys His Cys Arg Phe His Trp 
    50                  55                  60                  


Cys Cys Tyr Val Leu Cys Asp Glu Cys Lys Val Thr Glu Trp Val Asn 
65                  70                  75                  80  


Val Cys Lys 
            


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  68

Glu Ser Gly Gly Gly Gly Val Thr 
1               5               


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  69

Leu Glu Ser Gly Gly Gly Gly Val Thr 
1               5                   


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  70

Gly Arg Ala Gln Val Thr 
1               5       


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  71

Trp Arg Ala Gln Val Thr 
1               5       


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  72

Ala Arg Gly Arg Ala Gln Val Thr 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG peptide

<400>  73

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  74
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  74

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  75
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  76
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  77
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  77

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MET antibody Heavy chain CDR1

<400>  78

Gly Tyr Thr Phe Thr Ser Tyr Trp Leu His 
1               5                   10  


<210>  79
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MET antibody Heavy chain CDR2

<400>  79

Gly Met Ile Asp Pro Ser Asn Ser Asp Thr Arg Phe Asn Pro Asn Phe 
1               5                   10                  15      


Lys Asp 
        


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MET Heavy chain CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  wherein X is not R

<400>  80

Xaa Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr 
1               5                   10      


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MET Heavy chain CDR3

<400>  81

Thr Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr 
1               5                   10      


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MET Heavy chain CDR3

<400>  82

Ser Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr 
1               5                   10      


<210>  83
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MET Heavy chain CDR3

<400>  83

Ala Thr Tyr Gly Ser Tyr Val Ser Pro Leu Asp Tyr 
1               5                   10          


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MET Light chain CDR1

<400>  84

Lys Ser Ser Gln Ser Leu Leu Tyr Thr Ser Ser Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MET Light chain CDR2

<400>  85

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MET Light chain CDR3

<400>  86

Gln Gln Tyr Tyr Ala Tyr Pro Trp Thr 
1               5                   


<210>  87
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FZD8-Fc variant (13A variant) amino acid sequence without signal 
       sequence

<400>  87

Ala Ser Ala Lys Glu Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys 
1               5                   10                  15      


Lys Gly Ile Gly Tyr Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His 
            20                  25                  30          


Asp Thr Gln Asp Glu Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu 
        35                  40                  45              


Val Glu Ile Gln Cys Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met 
    50                  55                  60                  


Tyr Thr Pro Ile Cys Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys 
65                  70                  75                  80  


Arg Ser Val Cys Glu Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg 
                85                  90                  95      


Gln Tyr Gly Phe Ala Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro 
            100                 105                 110         


Glu Gln Gly Asn Pro Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp 
        115                 120                 125             


Leu Thr Thr Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser Cys Val 
    130                 135                 140                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
145                 150                 155                 160 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                165                 170                 175     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            180                 185                 190         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        195                 200                 205             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    210                 215                 220                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
225                 230                 235                 240 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                245                 250                 255     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            260                 265                 270         


Ser Arg Glu Lys Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        275                 280                 285             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    290                 295                 300                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Lys Ser Asp 
305                 310                 315                 320 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                325                 330                 335     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            340                 345                 350         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 365     


<210>  88
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R009 (13B variant) Heavy chain amino acid sequence without 
       signal sequence

<400>  88

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Thr Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Glu Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  89
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FZD8-Fc variant (13B variant) nucleotide sequence with signal 
       sequence

<400>  89
atggagtggg gttatctttt agaagtgacc tcgctgctag ccgccttgct actgctgcag       60

cgctctccga tcgtgcacgc cgcctcggcc aaggagctgg catgccaaga gatcaccgtg      120

ccgctatgca agggcatcgg ctacaactac acctacatgc ccaatcaatt caaccacgac      180

acgcaagacg aggcgggcct ggaggtgcac cagttctggc cgctggtgga gatccagtgc      240

tcgcccgatc tcaagttctt cctgtgcagc atgtacacgc ccatctgcct agaggactac      300

aagaagccgc tgccgccctg ccgctcggtg tgcgagcgcg ccaaggccgg ctgcgcgccg      360

ctcatgcgcc agtacggctt cgcctggccc gaccgcatgc gctgcgaccg gctgcccgag      420

caaggcaacc ctgacacgct gtgcatggac tacaaccgca ccgacctaac caccaccaaa      480

gttgacaaga ctgttgagcg aaagagctgc gttgagtgcc ctccatgtcc tgcacctcct      540

gtggctggcc cttctgtgtt cctgttccct ccaaaaccta aagacactct aatgatctct      600

cggactcctg aggtgacttg cgtggttgtg gacgtgtccc acgaggaccc tgaggtgcag      660

tttaattggt acgtggacgg agtcgaggtg cacaatgcaa agaccaagcc tcgggaggaa      720

cagttcaact ccaccttccg ggtggtttct gtgttgaccg ttgtgcacca agactggctg      780

aacggcaaag aatacaagtg caaggtgtcc aacaagggcc tgcctgcccc tatcgaaaag      840

accatcagca agaccaaggg ccagcctcgc gagcctcagg tgtacaccct gcctcccagc      900

cgggaagaaa tgaccaagaa ccaggtgtcc ctgacctgtc tggtggaggg cttctaccct      960

tccgacatcg ccgttgagtg ggagtctaac ggacagccgg agaacaacta caagactacg     1020

cctccaatgc tggactccga cggctccttc ttcctgtact ccgaactgac cgtggacaag     1080

tcccggtggc agcagggcaa cgtgttctca tgctccgtaa tgcacgaagc cttacacaat     1140

cactacactc aaaagtccct atccttatct cctggcaagt ag                        1182


<210>  90
<211>  1122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FZD8-Fc variant (13B variant) nucleotide sequence without signal 
       sequence

<400>  90
cgctctccga tcgtgcacgc cgcctcggcc aaggagctgg catgccaaga gatcaccgtg       60

ccgctatgca agggcatcgg ctacaactac acctacatgc ccaatcaatt caaccacgac      120

acgcaagacg aggcgggcct ggaggtgcac cagttctggc cgctggtgga gatccagtgc      180

tcgcccgatc tcaagttctt cctgtgcagc atgtacacgc ccatctgcct agaggactac      240

aagaagccgc tgccgccctg ccgctcggtg tgcgagcgcg ccaaggccgg ctgcgcgccg      300

ctcatgcgcc agtacggctt cgcctggccc gaccgcatgc gctgcgaccg gctgcccgag      360

caaggcaacc ctgacacgct gtgcatggac tacaaccgca ccgacctaac caccaccaaa      420

gttgacaaga ctgttgagcg aaagagctgc gttgagtgcc ctccatgtcc tgcacctcct      480

gtggctggcc cttctgtgtt cctgttccct ccaaaaccta aagacactct aatgatctct      540

cggactcctg aggtgacttg cgtggttgtg gacgtgtccc acgaggaccc tgaggtgcag      600

tttaattggt acgtggacgg agtcgaggtg cacaatgcaa agaccaagcc tcgggaggaa      660

cagttcaact ccaccttccg ggtggtttct gtgttgaccg ttgtgcacca agactggctg      720

aacggcaaag aatacaagtg caaggtgtcc aacaagggcc tgcctgcccc tatcgaaaag      780

accatcagca agaccaaggg ccagcctcgc gagcctcagg tgtacaccct gcctcccagc      840

cgggaagaaa tgaccaagaa ccaggtgtcc ctgacctgtc tggtggaggg cttctaccct      900

tccgacatcg ccgttgagtg ggagtctaac ggacagccgg agaacaacta caagactacg      960

cctccaatgc tggactccga cggctccttc ttcctgtact ccgaactgac cgtggacaag     1020

tcccggtggc agcagggcaa cgtgttctca tgctccgtaa tgcacgaagc cttacacaat     1080

cactacactc aaaagtccct atccttatct cctggcaagt ag                        1122


<210>  91
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  91

Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
1               5                   10                  15      


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            100                 105                 110         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Pro Gly Lys 
225                 230 


<210>  92
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  92

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  93
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  94
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Antibody 73R010 (73R009 H12) Heavy chain variable 
       region amino acid sequence

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  95
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 (73R009 L7) Light chain variable region amino acid 
       sequence

<400>  95

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  96
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 (73R009 H12) Heavy chain amino acid sequence with 
       predicted signal sequence

<400>  96

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Thr Ile 
        35                  40                  45              


Thr Ala Ser Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Phe Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
        195                 200                 205             


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  97
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 13A variant (73R009 H12) Heavy chain amino acid sequence 
       with predicted signal sequence

<400>  97

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Thr Ile 
        35                  40                  45              


Thr Ala Ser Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Phe Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
        195                 200                 205             


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Lys 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Lys Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  98
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 (73R009 L7) Light chain amino acid sequence with predicted
       signal sequence

<400>  98

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  99
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 (73R009 H12) Heavy chain amino acid sequence without 
       predicted signal sequence

<400>  99

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  100
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 13A Variant (73R009 H12) Heavy chain amino acid sequence 
       without predicted signal sequence

<400>  100

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Met Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  101
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 (73R009 L7) Light chain amino acid sequence without 
       predicted signal sequence

<400>  101

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  102
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R010 (73R009 H12) Heavy chain nucleotide sequence


<220>
<221>  misc_feature
<222>  (1104)..(1104)
<223>  R = A or G

<220>
<221>  misc_feature
<222>  (1230)..(1230)
<223>  Y = C or T

<400>  102
atgaaacatc tgtggttctt cctcctcctg gtggctgctc cccgctgggt cctgtcccaa       60

gtgcagctgc aggagtctgg cccaggactg gtgaagcctt ccgagaccct gtccctcacc      120

tgcaccgtct ctggaactac catcactgcc tcctatgcct ggagctggat tcggcagccc      180

cctggcaagg gactggagtg gatggggtac ataagctact ccgggggcac tgactacaac      240

ccatctctca aatcccgggt cacaatatca cgggacacat tcaagaacca gttctccctg      300

aaactctcct ctgtgaccgc tgctgacacc gccgtctatt actgtgcaag aaagggggct      360

tactggggcc aagggactct ggtcactgtc agctcagcct ctaccaaggg ccctagcgtc      420

ttccctctgg ccccctgctc ccggtccacc agcgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga acctgtgaca gtgtcctgga actccggcgc tctgaccagc      540

ggcgtgcaca ccttcccagc tgtcctccag tcctccggac tctactccct ctcctccgtg      600

gtgacagtgc cctcctccaa cttcggcacc cagacctaca cctgcaacgt cgatcacaag      660

cccagcaaca ccaaggttga taagacagtt gagcgcaaat gttgtgtcga gtgccctcct      720

tgcccagccc ctcctgtggc tggaccttcc gtcttcctct tcccccctaa acccaaagac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccccgagg tccagttcaa ctggtatgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccacggg aggagcagtt caacagcaca ttccgggtgg tcagcgtcct caccgttgtg      960

caccaggact ggctgaacgg caaggagtac aagtgcaaag tctccaacaa aggcctccct     1020

gcccccatcg agaaaaccat ctccaaaacc aaagggcagc ccagggaacc acaggtgtac     1080

accctgcccc cttcccggga ggaratgacc aagaaccaag tcagcctgac ctgcctggtc     1140

aaaggcttct acccctccga catcgccgtg gagtgggaga gcaatgggca gcctgagaac     1200

aactacaaga ccacacctcc catgctggay tccgacggct ccttcttcct ctactccaaa     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcctgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacacagaag tccctctccc tgtctcctgg aaaa           1374


<210>  103
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R010 13A variant (73R009 H12) Heavy chain nucleotide sequence

<400>  103
atgaaacatc tgtggttctt cctcctcctg gtggctgctc cccgctgggt cctgtcccaa       60

gtgcagctgc aggagtctgg cccaggactg gtgaagcctt ccgagaccct gtccctcacc      120

tgcaccgtct ctggaactac catcactgcc tcctatgcct ggagctggat tcggcagccc      180

cctggcaagg gactggagtg gatggggtac ataagctact ccgggggcac tgactacaac      240

ccatctctca aatcccgggt cacaatatca cgggacacat tcaagaacca gttctccctg      300

aaactctcct ctgtgaccgc tgctgacacc gccgtctatt actgtgcaag aaagggggct      360

tactggggcc aagggactct ggtcactgtc agctcagcct ctaccaaggg ccctagcgtc      420

ttccctctgg ccccctgctc ccggtccacc agcgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga acctgtgaca gtgtcctgga actccggcgc tctgaccagc      540

ggcgtgcaca ccttcccagc tgtcctccag tcctccggac tctactccct ctcctccgtg      600

gtgacagtgc cctcctccaa cttcggcacc cagacctaca cctgcaacgt cgatcacaag      660

cccagcaaca ccaaggttga taagacagtt gagcgcaaat gttgtgtcga gtgccctcct      720

tgcccagccc ctcctgtggc tggaccttcc gtcttcctct tcccccctaa acccaaagac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccccgagg tccagttcaa ctggtatgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccacggg aggagcagtt caacagcaca ttccgggtgg tcagcgtcct caccgttgtg      960

caccaggact ggctgaacgg caaggagtac aagtgcaaag tctccaacaa aggcctccct     1020

gcccccatcg agaaaaccat ctccaaaacc aaagggcagc ccagggaacc acaggtgtac     1080

accctgcccc cttcccggga gaagatgacc aagaaccaag tcagcctgac ctgcctggtc     1140

aaaggcttct acccctccga catcgccgtg gagtgggaga gcaatgggca gcctgagaac     1200

aactacaaga ccacacctcc catgctgaag tccgacggct ccttcttcct ctactccaaa     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcctgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacacagaag tccctctccc tgtctcctgg aaaa           1374


<210>  104
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R010 (73R009 H12) Heavy chain nucleotide sequence without 
       predicted signal sequence


<220>
<221>  misc_feature
<222>  (1047)..(1047)
<223>  R = A or G

<220>
<221>  misc_feature
<222>  (1173)..(1173)
<223>  Y = C or T

<400>  104
caagtgcagc tgcaggagtc tggcccagga ctggtgaagc cttccgagac cctgtccctc       60

acctgcaccg tctctggaac taccatcact gcctcctatg cctggagctg gattcggcag      120

ccccctggca agggactgga gtggatgggg tacataagct actccggggg cactgactac      180

aacccatctc tcaaatcccg ggtcacaata tcacgggaca cattcaagaa ccagttctcc      240

ctgaaactct cctctgtgac cgctgctgac accgccgtct attactgtgc aagaaagggg      300

gcttactggg gccaagggac tctggtcact gtcagctcag cctctaccaa gggccctagc      360

gtcttccctc tggccccctg ctcccggtcc accagcgaga gcacagccgc cctgggctgc      420

ctggtcaagg actacttccc cgaacctgtg acagtgtcct ggaactccgg cgctctgacc      480

agcggcgtgc acaccttccc agctgtcctc cagtcctccg gactctactc cctctcctcc      540

gtggtgacag tgccctcctc caacttcggc acccagacct acacctgcaa cgtcgatcac      600

aagcccagca acaccaaggt tgataagaca gttgagcgca aatgttgtgt cgagtgccct      660

ccttgcccag cccctcctgt ggctggacct tccgtcttcc tcttcccccc taaacccaaa      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccccg aggtccagtt caactggtat gtggacggcg tggaggtgca taatgccaag      840

acaaagccac gggaggagca gttcaacagc acattccggg tggtcagcgt cctcaccgtt      900

gtgcaccagg actggctgaa cggcaaggag tacaagtgca aagtctccaa caaaggcctc      960

cctgccccca tcgagaaaac catctccaaa accaaagggc agcccaggga accacaggtg     1020

tacaccctgc ccccttcccg ggaggaratg accaagaacc aagtcagcct gacctgcctg     1080

gtcaaaggct tctacccctc cgacatcgcc gtggagtggg agagcaatgg gcagcctgag     1140

aacaactaca agaccacacc tcccatgctg gaytccgacg gctccttctt cctctactcc     1200

aaactcaccg tggacaagag caggtggcag caggggaacg tcttctcctg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacacag aagtccctct ccctgtctcc tggaaaa        1317


<210>  105
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R010 13A variant (73R009 H12) Heavy chain nucleotide sequence 
       without predicted signal sequence

<400>  105
caagtgcagc tgcaggagtc tggcccagga ctggtgaagc cttccgagac cctgtccctc       60

acctgcaccg tctctggaac taccatcact gcctcctatg cctggagctg gattcggcag      120

ccccctggca agggactgga gtggatgggg tacataagct actccggggg cactgactac      180

aacccatctc tcaaatcccg ggtcacaata tcacgggaca cattcaagaa ccagttctcc      240

ctgaaactct cctctgtgac cgctgctgac accgccgtct attactgtgc aagaaagggg      300

gcttactggg gccaagggac tctggtcact gtcagctcag cctctaccaa gggccctagc      360

gtcttccctc tggccccctg ctcccggtcc accagcgaga gcacagccgc cctgggctgc      420

ctggtcaagg actacttccc cgaacctgtg acagtgtcct ggaactccgg cgctctgacc      480

agcggcgtgc acaccttccc agctgtcctc cagtcctccg gactctactc cctctcctcc      540

gtggtgacag tgccctcctc caacttcggc acccagacct acacctgcaa cgtcgatcac      600

aagcccagca acaccaaggt tgataagaca gttgagcgca aatgttgtgt cgagtgccct      660

ccttgcccag cccctcctgt ggctggacct tccgtcttcc tcttcccccc taaacccaaa      720

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      780

gaagaccccg aggtccagtt caactggtat gtggacggcg tggaggtgca taatgccaag      840

acaaagccac gggaggagca gttcaacagc acattccggg tggtcagcgt cctcaccgtt      900

gtgcaccagg actggctgaa cggcaaggag tacaagtgca aagtctccaa caaaggcctc      960

cctgccccca tcgagaaaac catctccaaa accaaagggc agcccaggga accacaggtg     1020

tacaccctgc ccccttcccg ggagaagatg accaagaacc aagtcagcct gacctgcctg     1080

gtcaaaggct tctacccctc cgacatcgcc gtggagtggg agagcaatgg gcagcctgag     1140

aacaactaca agaccacacc tcccatgctg aagtccgacg gctccttctt cctctactcc     1200

aaactcaccg tggacaagag caggtggcag caggggaacg tcttctcctg ctccgtgatg     1260

catgaggctc tgcacaacca ctacacacag aagtccctct ccctgtctcc tggaaaa        1317


<210>  106
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R010 (73R009 L7) Light chain nucleotide sequence

<400>  106
atggaaaccc cagctcaact cctcttcctc ctgctcctct ggctccccga taccaccgga       60

gaaattgtgc tcactcagtc tcccgctacc ctgtctctct ctcctgggga aagagccacc      120

ctctcctgct ctgcctcctc atccgtttct tcctcctacc tctactggta ccagcagaaa      180

cctggccagg ctcccaggct cctcatctat agcacatcca acctggcttc tggcatccca      240

gctaggttct ctggctctgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcat cagtggtcat cctacccata cacattcggc      360

cagggaacca aactggagat taagcgtacg gtggcagccc cttctgtctt tatcttccct      420

ccatccgacg agcagctcaa atcaggaacc gcttctgtcg tgtgcctgct taacaatttc      480

tacccacggg aagccaaggt gcagtggaag gtggacaatg ccctgcaatc aggtaattcc      540

caagagtcag tgactgaaca ggatagcaag gacagcacct attcactctc cagcactctg      600

accctgtcca aggctgacta cgaaaagcat aaggtgtacg catgcgaggt gacccaccag      660

ggtctgagca gccccgtcac caagtctttc aacagagggg agtgt                      705


<210>  107
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R010 (73R009 L7) Light chain nucleotide sequence without 
       predicted signal sequence

<400>  107
gaaattgtgc tcactcagtc tcccgctacc ctgtctctct ctcctgggga aagagccacc       60

ctctcctgct ctgcctcctc atccgtttct tcctcctacc tctactggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat agcacatcca acctggcttc tggcatccca      180

gctaggttct ctggctctgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcat cagtggtcat cctacccata cacattcggc      300

cagggaacca aactggagat taagcgtacg gtggcagccc cttctgtctt tatcttccct      360

ccatccgacg agcagctcaa atcaggaacc gcttctgtcg tgtgcctgct taacaatttc      420

tacccacggg aagccaaggt gcagtggaag gtggacaatg ccctgcaatc aggtaattcc      480

caagagtcag tgactgaaca ggatagcaag gacagcacct attcactctc cagcactctg      540

accctgtcca aggctgacta cgaaaagcat aaggtgtacg catgcgaggt gacccaccag      600

ggtctgagca gccccgtcac caagtctttc aacagagggg agtgt                      645


<210>  108
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3R010 13B Variant (73R009 H12) Heavy chain amino acid sequence 
       without predicted signal sequence

<400>  108

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Glu Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  109
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73R010 13A Variant (Cys/Ser) (73R009 H12) Heavy chain nucleotide 
       sequence

<400>  109
atgaaacatc tgtggttctt cctcctcctg gtggctgctc cccgctgggt cctgtcccaa       60

gtgcagctgc aggagtctgg cccaggactg gtgaagcctt ccgagaccct gtccctcacc      120

tgcaccgtct ctggaactac catcactgcc tcctatgcct ggagctggat tcggcagccc      180

cctggcaagg gactggagtg gatggggtac ataagctact ccgggggcac tgactacaac      240

ccatctctca aatcccgggt cacaatatca cgggacacat tcaagaacca gttctccctg      300

aaactctcct ctgtgaccgc tgctgacacc gccgtctatt actgtgcaag aaagggggct      360

tactggggcc aagggactct ggtcactgtc agctcagcct caactaaggg ccctagcgtc      420

ttccctctgg ccccctgctc ccggtccacc agcgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga acctgtgaca gtgtcctgga actccggcgc tctgaccagc      540

ggcgtgcaca ccttcccagc tgtcctccag tcctccggac tctactccct ctcctccgtg      600

gtgacagtgc cctcctccaa cttcggcacc cagacctaca cctgcaacgt cgatcacaag      660

cccagcaaca ccaaggttga taagacagtt gagcgcaaat cttgtgtcga gtgccctcct      720

tgcccagccc ctcctgtggc tggaccttcc gtcttcctct tcccccctaa acccaaagac      780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      840

gaccccgagg tccagttcaa ctggtatgtg gacggcgtgg aggtgcataa tgccaagaca      900

aagccacggg aggagcagtt caacagcaca ttccgggtgg tcagcgtcct caccgttgtg      960

caccaggact ggctgaacgg caaggagtac aagtgcaaag tctccaacaa aggcctccct     1020

gcccccatcg agaaaaccat ctccaaaacc aaagggcagc ccagggaacc acaggtgtac     1080

accctgcccc cttcccggga gaagatgacc aagaaccaag tcagcctgac ctgcctggtc     1140

aaaggcttct acccctccga catcgccgtg gagtgggaga gcaatgggca gcctgagaac     1200

aactacaaga ccacacctcc catgctgaag tccgacggct ccttcttcct ctactccaaa     1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcctgctc cgtgatgcat     1320

gaggctctgc acaaccacta cacacagaag tccctctccc tgtctcctgg aaaatga        1377


<210>  110
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 13A Variant (Cys/Ser) (73R009 H12) Heavy chain amino acid 
       sequence with predicted signal sequence

<400>  110

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Thr Ile 
        35                  40                  45              


Thr Ala Ser Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Phe Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
        195                 200                 205             


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Thr Val Glu Arg Lys Ser Cys Val Glu Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Lys 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Lys Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  111
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 13A Variant (Cys/Ser) (73R009 H12) Heavy chain amino acid 
       sequence without predicted signal sequence

<400>  111

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Met Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  112
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 (Cys/Ser) (73R009 H12) Heavy chain amino acid sequence 
       without predicted signal sequence

<400>  112

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  113
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MET

<400>  113

Pro Cys Gln Asp Cys 
1               5   


<210>  114
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73R010 13B Variant (Cys/Ser) (73R009 H12) Heavy chain amino acid 
       sequence without predicted signal sequence

<400>  114

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Thr Thr Ile Thr Ala Ser 
            20                  25                  30          


Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Gly Thr Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Phe Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Glu Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


