                         SEQUENCE LISTING

<110>  Five Prime Therapeutics, Inc.
 
<120>  FAM150A, FAM150B, AND FAM150 ANTAGONISTS AND USES THEREOF

<130>  FPT-32537/WO-1/ORD

<150>  US 61/777,034
<151>  2013-03-12

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Leu Lys Pro Gly Ala Pro Leu Pro Ala Leu Phe Leu Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ser Pro His Gly Ala His Gly Arg Pro Arg Gly Arg 
            20                  25                  30          


Arg Gly Ala Arg Val Thr Asp Lys Glu Pro Lys Pro Leu Leu Phe Leu 
        35                  40                  45              


Pro Ala Ala Gly Ala Gly Arg Thr Pro Ser Gly Ser Arg Ser Ala Glu 
    50                  55                  60                  


Ile Phe Pro Arg Asp Ser Asn Leu Lys Asp Lys Phe Ile Lys His Phe 
65                  70                  75                  80  


Thr Gly Pro Val Thr Phe Ser Pro Glu Cys Ser Lys His Phe His Arg 
                85                  90                  95      


Leu Tyr Tyr Asn Thr Arg Glu Cys Ser Thr Pro Ala Tyr Tyr Lys Arg 
            100                 105                 110         


Cys Ala Arg Leu Leu Thr Arg Leu Ala Val Ser Pro Leu Cys Ser Gln 
        115                 120                 125             


Thr 
    


<210>  2
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Pro Arg Gly Arg Arg Gly Ala Arg Val Thr Asp Lys Glu Pro Lys 
1               5                   10                  15      


Pro Leu Leu Phe Leu Pro Ala Ala Gly Ala Gly Arg Thr Pro Ser Gly 
            20                  25                  30          


Ser Arg Ser Ala Glu Ile Phe Pro Arg Asp Ser Asn Leu Lys Asp Lys 
        35                  40                  45              


Phe Ile Lys His Phe Thr Gly Pro Val Thr Phe Ser Pro Glu Cys Ser 
    50                  55                  60                  


Lys His Phe His Arg Leu Tyr Tyr Asn Thr Arg Glu Cys Ser Thr Pro 
65                  70                  75                  80  


Ala Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg Leu Ala Val Ser 
                85                  90                  95      


Pro Leu Cys Ser Gln Thr 
            100         


<210>  3
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Gly Pro Gly His Pro Leu Leu Leu Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Gly Ala Ala Gly Arg Gly Arg Gly Gly Ala Glu Pro Arg Glu Pro Ala 
            20                  25                  30          


Asp Gly Gln Ala Leu Leu Arg Leu Val Val Glu Leu Val Gln Glu Leu 
        35                  40                  45              


Arg Lys His His Ser Ala Glu His Lys Gly Leu Gln Leu Leu Gly Arg 
    50                  55                  60                  


Asp Cys Ala Leu Gly Arg Ala Glu Ala Ala Gly Leu Gly Pro Ser Pro 
65                  70                  75                  80  


Glu Gln Arg Val Glu Ile Val Pro Arg Asp Leu Arg Met Lys Asp Lys 
                85                  90                  95      


Phe Leu Lys His Leu Thr Gly Pro Leu Tyr Phe Ser Pro Lys Cys Ser 
            100                 105                 110         


Lys His Phe His Arg Leu Tyr His Asn Thr Arg Asp Cys Thr Ile Pro 
        115                 120                 125             


Ala Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg Leu Ala Val Ser 
    130                 135                 140                 


Pro Val Cys Met Glu Asp Lys Gln 
145                 150         


<210>  4
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Ala Glu Pro Arg Glu Pro Ala Asp Gly Gln Ala Leu Leu Arg Leu 
1               5                   10                  15      


Val Val Glu Leu Val Gln Glu Leu Arg Lys His His Ser Ala Glu His 
            20                  25                  30          


Lys Gly Leu Gln Leu Leu Gly Arg Asp Cys Ala Leu Gly Arg Ala Glu 
        35                  40                  45              


Ala Ala Gly Leu Gly Pro Ser Pro Glu Gln Arg Val Glu Ile Val Pro 
    50                  55                  60                  


Arg Asp Leu Arg Met Lys Asp Lys Phe Leu Lys His Leu Thr Gly Pro 
65                  70                  75                  80  


Leu Tyr Phe Ser Pro Lys Cys Ser Lys His Phe His Arg Leu Tyr His 
                85                  90                  95      


Asn Thr Arg Asp Cys Thr Ile Pro Ala Tyr Tyr Lys Arg Cys Ala Arg 
            100                 105                 110         


Leu Leu Thr Arg Leu Ala Val Ser Pro Val Cys Met Glu Asp Lys Gln 
        115                 120                 125             


<210>  5
<211>  151
<212>  PRT
<213>  Mus musculus

<400>  5

Met Arg Val Ser Gly Arg Pro Met Leu Leu Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Thr Thr Val Gly Asp Arg Gly Arg Ala Gln Ser Arg Gly Pro Ala Asp 
            20                  25                  30          


Arg Gln Thr Leu Leu Arg Leu Leu Val Glu Leu Val Gln Glu Leu Lys 
        35                  40                  45              


Lys Phe His Ile Gly Asp Ser Lys Arg Leu Gln Leu Leu Gly Glu Ser 
    50                  55                  60                  


Asp Phe Ala Leu Gly Arg Arg Glu Ala Thr Asp Tyr Gly Ala Asp Gln 
65                  70                  75                  80  


Glu Glu Gln Arg Val Glu Ile Val Pro Arg Asp Leu Arg Met Lys Asp 
                85                  90                  95      


Lys Phe Leu Lys His Leu Thr Gly Pro Leu Tyr Phe Ser Pro Lys Cys 
            100                 105                 110         


Ser Lys His Phe His Arg Leu Tyr His Asn Thr Arg Asp Cys Thr Ile 
        115                 120                 125             


Pro Ala Tyr Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg Leu Ala Val 
    130                 135                 140                 


Ser Pro Met Cys Met Glu Arg 
145                 150     


<210>  6
<211>  126
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Ser Arg Gly Pro Ala Asp Arg Gln Thr Leu Leu Arg Leu Leu Val 
1               5                   10                  15      


Glu Leu Val Gln Glu Leu Lys Lys Phe His Ile Gly Asp Ser Lys Arg 
            20                  25                  30          


Leu Gln Leu Leu Gly Glu Ser Asp Phe Ala Leu Gly Arg Arg Glu Ala 
        35                  40                  45              


Thr Asp Tyr Gly Ala Asp Gln Glu Glu Gln Arg Val Glu Ile Val Pro 
    50                  55                  60                  


Arg Asp Leu Arg Met Lys Asp Lys Phe Leu Lys His Leu Thr Gly Pro 
65                  70                  75                  80  


Leu Tyr Phe Ser Pro Lys Cys Ser Lys His Phe His Arg Leu Tyr His 
                85                  90                  95      


Asn Thr Arg Asp Cys Thr Ile Pro Ala Tyr Tyr Lys Arg Cys Ala Arg 
            100                 105                 110         


Leu Leu Thr Arg Leu Ala Val Ser Pro Met Cys Met Glu Arg 
        115                 120                 125     


<210>  7
<211>  864
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Gly Gly Gly Trp Thr Ser Arg Ala Pro Ser Pro Gln Ala Gly Arg 
        275                 280                 285             


Ser Leu Gln Glu Gly Ala Glu Gly Gly Gln Gly Cys Ser Glu Ala Trp 
    290                 295                 300                 


Ala Thr Leu Gly Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Ala Cys Thr Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Ala 
                325                 330                 335     


Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly Val Ser Phe 
            340                 345                 350         


Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala Val Thr Glu 
        355                 360                 365             


Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys Ser His Cys 
    370                 375                 380                 


Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu Ala Glu Cys 
385                 390                 395                 400 


Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val Thr Cys Met 
                405                 410                 415     


Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val Ala Val Val 
            420                 425                 430         


Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val Leu Ile Leu 
        435                 440                 445             


Val Lys Gln Lys Lys Trp Gln Gly Leu Gln Glu Met Arg Leu Pro Ser 
    450                 455                 460                 


Pro Glu Leu Glu Leu Ser Lys Leu Arg Thr Ser Ala Ile Arg Thr Ala 
465                 470                 475                 480 


Pro Asn Pro Tyr Tyr Cys Gln Val Gly Leu Gly Pro Ala Gln Ser Trp 
                485                 490                 495     


Pro Leu Pro Pro Gly Val Thr Glu Val Ser Pro Ala Asn Val Thr Leu 
            500                 505                 510         


Leu Arg Ala Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Leu 
        515                 520                 525             


Val Ile Gly Leu Pro Gly Asp Ser Ser Pro Leu Gln Val Ala Ile Lys 
    530                 535                 540                 


Thr Leu Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp Phe Leu Met 
545                 550                 555                 560 


Glu Ala Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile Val Arg Cys 
                565                 570                 575     


Val Gly Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu Leu Glu Leu 
            580                 585                 590         


Met Ser Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser Arg Pro His 
        595                 600                 605             


Leu Gly Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu Gln Leu Ala 
    610                 615                 620                 


Gln Asp Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn His Phe Ile 
625                 630                 635                 640 


His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys Ala Gly Pro 
                645                 650                 655     


Ser Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr 
            660                 665                 670         


Arg Ala Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu Pro Val Lys 
        675                 680                 685             


Trp Met Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr Ser Lys Thr 
    690                 695                 700                 


Asp Ser Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly 
705                 710                 715                 720 


Tyr Met Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu Asp Phe Val 
                725                 730                 735     


Val Gly Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro Gly Pro Val 
            740                 745                 750         


Tyr Arg Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu Leu Arg Pro 
        755                 760                 765             


Ser Phe Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr Gln Asp Pro 
    770                 775                 780                 


Asp Val Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro Thr Pro Glu 
785                 790                 795                 800 


Glu Glu Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu Cys Leu Arg 
                805                 810                 815     


Pro Pro Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys Ser Trp Gly 
            820                 825                 830         


Gly Ser Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys Pro Leu Lys 
        835                 840                 845             


Ser Arg Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr Tyr Arg Ser 
    850                 855                 860                 


<210>  8
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
1               5                   10                  15      


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
            20                  25                  30          


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
        35                  40                  45              


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
    50                  55                  60                  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
65                  70                  75                  80  


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
                85                  90                  95      


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
            100                 105                 110         


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
        115                 120                 125             


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
    130                 135                 140                 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
145                 150                 155                 160 


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
                165                 170                 175     


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
        195                 200                 205             


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
    210                 215                 220                 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
225                 230                 235                 240 


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
                245                 250                 255     


Gly Gly Gly Gly Trp Thr Ser Arg Ala Pro Ser Pro Gln Ala Gly Arg 
            260                 265                 270         


Ser Leu Gln Glu Gly Ala Glu Gly Gly Gln Gly Cys Ser Glu Ala Trp 
        275                 280                 285             


Ala Thr Leu Gly Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly 
    290                 295                 300                 


Ala Cys Thr Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Ala 
305                 310                 315                 320 


Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly Val Ser Phe 
                325                 330                 335     


Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala Val Thr Glu 
            340                 345                 350         


Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys Ser His Cys 
        355                 360                 365             


Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu Ala Glu Cys 
    370                 375                 380                 


Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val Thr Cys Met 
385                 390                 395                 400 


Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val Ala Val Val 
                405                 410                 415     


Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val Leu Ile Leu 
            420                 425                 430         


Val Lys Gln Lys Lys Trp Gln Gly Leu Gln Glu Met Arg Leu Pro Ser 
        435                 440                 445             


Pro Glu Leu Glu Leu Ser Lys Leu Arg Thr Ser Ala Ile Arg Thr Ala 
    450                 455                 460                 


Pro Asn Pro Tyr Tyr Cys Gln Val Gly Leu Gly Pro Ala Gln Ser Trp 
465                 470                 475                 480 


Pro Leu Pro Pro Gly Val Thr Glu Val Ser Pro Ala Asn Val Thr Leu 
                485                 490                 495     


Leu Arg Ala Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Leu 
            500                 505                 510         


Val Ile Gly Leu Pro Gly Asp Ser Ser Pro Leu Gln Val Ala Ile Lys 
        515                 520                 525             


Thr Leu Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp Phe Leu Met 
    530                 535                 540                 


Glu Ala Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile Val Arg Cys 
545                 550                 555                 560 


Val Gly Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu Leu Glu Leu 
                565                 570                 575     


Met Ser Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser Arg Pro His 
            580                 585                 590         


Leu Gly Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu Gln Leu Ala 
        595                 600                 605             


Gln Asp Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn His Phe Ile 
    610                 615                 620                 


His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys Ala Gly Pro 
625                 630                 635                 640 


Ser Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr 
                645                 650                 655     


Arg Ala Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu Pro Val Lys 
            660                 665                 670         


Trp Met Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr Ser Lys Thr 
        675                 680                 685             


Asp Ser Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly 
    690                 695                 700                 


Tyr Met Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu Asp Phe Val 
705                 710                 715                 720 


Val Gly Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro Gly Pro Val 
                725                 730                 735     


Tyr Arg Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu Leu Arg Pro 
            740                 745                 750         


Ser Phe Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr Gln Asp Pro 
        755                 760                 765             


Asp Val Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro Thr Pro Glu 
    770                 775                 780                 


Glu Glu Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu Cys Leu Arg 
785                 790                 795                 800 


Pro Pro Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys Ser Trp Gly 
                805                 810                 815     


Gly Ser Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys Pro Leu Lys 
            820                 825                 830         


Ser Arg Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr Tyr Arg Ser 
        835                 840                 845             


<210>  9
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Asp Ala Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly 
        275                 280                 285             


Val Ser Phe Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala 
    290                 295                 300                 


Val Thr Glu Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys 
305                 310                 315                 320 


Ser His Cys Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu 
                325                 330                 335     


Ala Glu Cys Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val 
            340                 345                 350         


Thr Cys Met Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val 
        355                 360                 365             


Ala Val Val Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val 
    370                 375                 380                 


Leu Ile Leu Val Lys Gln Lys Lys Trp Gln Gly Leu Gln Glu Met Arg 
385                 390                 395                 400 


Leu Pro Ser Pro Glu Leu Glu Leu Ser Lys Leu Arg Thr Ser Ala Ile 
                405                 410                 415     


Arg Thr Ala Pro Asn Pro Tyr Tyr Cys Gln Val Gly Leu Gly Pro Ala 
            420                 425                 430         


Gln Ser Trp Pro Leu Pro Pro Gly Val Thr Glu Val Ser Pro Ala Asn 
        435                 440                 445             


Val Thr Leu Leu Arg Ala Leu Gly His Gly Ala Phe Gly Glu Val Tyr 
    450                 455                 460                 


Glu Gly Leu Val Ile Gly Leu Pro Gly Asp Ser Ser Pro Leu Gln Val 
465                 470                 475                 480 


Ala Ile Lys Thr Leu Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp 
                485                 490                 495     


Phe Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile 
            500                 505                 510         


Val Arg Cys Val Gly Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu 
        515                 520                 525             


Leu Glu Leu Met Ser Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser 
    530                 535                 540                 


Arg Pro His Leu Gly Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu 
545                 550                 555                 560 


Gln Leu Ala Gln Asp Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn 
                565                 570                 575     


His Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys 
            580                 585                 590         


Ala Gly Pro Ser Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg 
        595                 600                 605             


Asp Ile Tyr Arg Ala Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu 
    610                 615                 620                 


Pro Val Lys Trp Met Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr 
625                 630                 635                 640 


Ser Lys Thr Asp Ser Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
                645                 650                 655     


Ser Leu Gly Tyr Met Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu 
            660                 665                 670         


Asp Phe Val Val Gly Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro 
        675                 680                 685             


Gly Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu 
    690                 695                 700                 


Leu Arg Pro Ser Phe Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr 
705                 710                 715                 720 


Gln Asp Pro Asp Val Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro 
                725                 730                 735     


Thr Pro Glu Glu Glu Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu 
            740                 745                 750         


Cys Leu Arg Pro Pro Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys 
        755                 760                 765             


Ser Trp Gly Gly Ser Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys 
    770                 775                 780                 


Pro Leu Lys Ser Arg Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr 
785                 790                 795                 800 


Tyr Arg Ser 
            


<210>  10
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
1               5                   10                  15      


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
            20                  25                  30          


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
        35                  40                  45              


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
    50                  55                  60                  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
65                  70                  75                  80  


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
                85                  90                  95      


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
            100                 105                 110         


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
        115                 120                 125             


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
    130                 135                 140                 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
145                 150                 155                 160 


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
                165                 170                 175     


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
        195                 200                 205             


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
    210                 215                 220                 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
225                 230                 235                 240 


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
                245                 250                 255     


Gly Asp Ala Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly 
            260                 265                 270         


Val Ser Phe Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala 
        275                 280                 285             


Val Thr Glu Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys 
    290                 295                 300                 


Ser His Cys Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu 
305                 310                 315                 320 


Ala Glu Cys Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val 
                325                 330                 335     


Thr Cys Met Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val 
            340                 345                 350         


Ala Val Val Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val 
        355                 360                 365             


Leu Ile Leu Val Lys Gln Lys Lys Trp Gln Gly Leu Gln Glu Met Arg 
    370                 375                 380                 


Leu Pro Ser Pro Glu Leu Glu Leu Ser Lys Leu Arg Thr Ser Ala Ile 
385                 390                 395                 400 


Arg Thr Ala Pro Asn Pro Tyr Tyr Cys Gln Val Gly Leu Gly Pro Ala 
                405                 410                 415     


Gln Ser Trp Pro Leu Pro Pro Gly Val Thr Glu Val Ser Pro Ala Asn 
            420                 425                 430         


Val Thr Leu Leu Arg Ala Leu Gly His Gly Ala Phe Gly Glu Val Tyr 
        435                 440                 445             


Glu Gly Leu Val Ile Gly Leu Pro Gly Asp Ser Ser Pro Leu Gln Val 
    450                 455                 460                 


Ala Ile Lys Thr Leu Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp 
465                 470                 475                 480 


Phe Leu Met Glu Ala Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile 
                485                 490                 495     


Val Arg Cys Val Gly Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu 
            500                 505                 510         


Leu Glu Leu Met Ser Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser 
        515                 520                 525             


Arg Pro His Leu Gly Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu 
    530                 535                 540                 


Gln Leu Ala Gln Asp Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn 
545                 550                 555                 560 


His Phe Ile His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys 
                565                 570                 575     


Ala Gly Pro Ser Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg 
            580                 585                 590         


Asp Ile Tyr Arg Ala Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu 
        595                 600                 605             


Pro Val Lys Trp Met Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr 
    610                 615                 620                 


Ser Lys Thr Asp Ser Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
625                 630                 635                 640 


Ser Leu Gly Tyr Met Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu 
                645                 650                 655     


Asp Phe Val Val Gly Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro 
            660                 665                 670         


Gly Pro Val Tyr Arg Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu 
        675                 680                 685             


Leu Arg Pro Ser Phe Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr 
    690                 695                 700                 


Gln Asp Pro Asp Val Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro 
705                 710                 715                 720 


Thr Pro Glu Glu Glu Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu 
                725                 730                 735     


Cys Leu Arg Pro Pro Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys 
            740                 745                 750         


Ser Trp Gly Gly Ser Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys 
        755                 760                 765             


Pro Leu Lys Ser Arg Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr 
    770                 775                 780                 


Tyr Arg Ser 
785         


<210>  11
<211>  888
<212>  PRT
<213>  Mus musculus

<400>  11

Met Gly Cys Ser His Arg Leu Leu Leu Trp Leu Gly Ala Ala Gly Thr 
1               5                   10                  15      


Ile Leu Cys Ser Asn Ser Glu Phe Gln Ala Pro Phe Leu Thr Pro Ser 
            20                  25                  30          


Leu Leu Pro Val Leu Val Leu Asn Ser Gln Glu Gln Lys Val Thr Pro 
        35                  40                  45              


Thr Pro Ser Lys Leu Glu Pro Ala Ser Leu Pro Asn Pro Leu Gly Thr 
    50                  55                  60                  


Arg Gly Pro Trp Val Phe Asn Thr Cys Gly Ala Ser Gly Arg Ser Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Thr Gly Ser Ser Val Met 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Pro Leu Lys Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Ala Pro Asp Thr Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Gln Asn His Leu Ser Arg Ala His Gly Ile Phe Leu 
    130                 135                 140                 


Ser Ala Val Phe Phe Leu Arg Arg Gly Glu Pro Val Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Gln Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Gly Glu His Ala Thr Thr Tyr Gly Thr 
            180                 185                 190         


Glu Arg Ile Pro Gly Trp Arg Arg Trp Ala Gly Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Gly Ala Thr Ser Ile Phe Arg Leu Arg Ala Gly Glu Pro Glu Pro 
    210                 215                 220                 


Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ser Tyr Arg Arg Arg Pro 
225                 230                 235                 240 


Asp Arg Gly Arg Thr Gln Ala Val Pro Glu Arg Leu Glu Thr Arg Ala 
                245                 250                 255     


Ala Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly Gly Gly Ser 
            260                 265                 270         


Gly Trp Thr Ser Arg Ala His Ser Pro Gln Ala Gly Arg Ser Pro Arg 
        275                 280                 285             


Glu Gly Ala Glu Gly Gly Glu Gly Cys Ala Glu Ala Trp Ala Ala Leu 
    290                 295                 300                 


Arg Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly Ala Cys Ala 
305                 310                 315                 320 


Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Thr Ser Glu Ser 
                325                 330                 335     


Asp Leu Leu Trp Ala Asp Gly Glu Asp Gly Thr Ser Phe Val His Pro 
            340                 345                 350         


Ser Gly Glu Leu Tyr Leu Gln Pro Leu Ala Val Thr Glu Gly His Gly 
        355                 360                 365             


Glu Val Glu Ile Arg Lys His Pro Asn Cys Ser His Cys Pro Phe Lys 
    370                 375                 380                 


Asp Cys Gln Trp Gln Ala Glu Leu Trp Thr Ala Glu Cys Thr Cys Pro 
385                 390                 395                 400 


Glu Gly Thr Glu Leu Ala Val Asp Asn Val Thr Cys Met Asp Leu Pro 
                405                 410                 415     


Thr Thr Ala Ser Pro Leu Ile Leu Met Gly Ala Val Val Ala Ala Leu 
            420                 425                 430         


Ala Leu Ser Leu Leu Met Met Cys Ala Val Leu Ile Leu Val Asn Gln 
        435                 440                 445             


Lys Cys Gln Gly Leu Trp Gly Thr Arg Leu Pro Gly Pro Glu Leu Glu 
    450                 455                 460                 


Leu Ser Lys Leu Arg Ser Ser Ala Ile Arg Thr Ala Pro Asn Pro Tyr 
465                 470                 475                 480 


Tyr Cys Gln Val Gly Leu Ser Pro Ala Gln Pro Trp Pro Leu Pro Pro 
                485                 490                 495     


Gly Leu Thr Glu Val Ser Pro Ala Asn Val Thr Leu Leu Arg Ala Leu 
            500                 505                 510         


Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Leu Val Thr Gly Leu 
        515                 520                 525             


Pro Gly Asp Ser Ser Pro Leu Pro Val Ala Ile Lys Thr Leu Pro Glu 
    530                 535                 540                 


Leu Cys Ser His Gln Asp Glu Leu Asp Phe Leu Met Glu Ala Leu Ile 
545                 550                 555                 560 


Ile Ser Lys Phe Ser His Gln Asn Ile Val Arg Cys Val Gly Leu Ser 
                565                 570                 575     


Phe Arg Ser Ala Pro Arg Leu Ile Leu Leu Glu Leu Met Ser Gly Gly 
            580                 585                 590         


Asp Met Lys Ser Phe Leu Arg His Ser Arg Pro His Pro Gly Gln Leu 
        595                 600                 605             


Ala Pro Leu Thr Met Gln Asp Leu Leu Gln Leu Ala Gln Asp Ile Ala 
    610                 615                 620                 


Gln Gly Cys His Tyr Leu Glu Glu Asn His Phe Ile His Arg Asp Ile 
625                 630                 635                 640 


Ala Ala Arg Asn Cys Leu Leu Ser Cys Ser Gly Ala Ser Arg Val Ala 
                645                 650                 655     


Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr Gln Ala Ser Tyr 
            660                 665                 670         


Tyr Arg Lys Gly Gly Arg Thr Leu Leu Pro Val Lys Trp Met Pro Pro 
        675                 680                 685             


Glu Ala Leu Leu Glu Gly Leu Phe Thr Ser Lys Thr Asp Ser Trp Ser 
    690                 695                 700                 


Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Tyr Met Pro Tyr 
705                 710                 715                 720 


Pro Gly His Thr Asn Gln Glu Val Leu Asp Phe Ile Ala Thr Gly Asn 
                725                 730                 735     


Arg Met Asp Pro Pro Arg Asn Cys Pro Gly Pro Val Tyr Arg Ile Met 
            740                 745                 750         


Thr Gln Cys Trp Gln His Gln Pro Glu Leu Arg Pro Asp Phe Gly Ser 
        755                 760                 765             


Ile Leu Glu Arg Ile Gln Tyr Cys Thr Gln Asp Pro Asp Val Leu Asn 
    770                 775                 780                 


Ser Pro Leu Pro Met Glu Pro Gly Pro Ile Leu Glu Glu Glu Glu Ala 
785                 790                 795                 800 


Ser Arg Leu Gly Asn Arg Ser Leu Glu Gly Leu Arg Ser Pro Lys Pro 
                805                 810                 815     


Leu Glu Leu Ser Ser Gln Asn Leu Lys Ser Trp Gly Gly Gly Leu Leu 
            820                 825                 830         


Gly Ser Trp Leu Pro Ser Gly Leu Lys Thr Leu Lys Pro Arg Cys Leu 
        835                 840                 845             


Gln Pro Gln Asn Ile Trp Asn Pro Thr Tyr Gly Ser Trp Thr Pro Arg 
    850                 855                 860                 


Gly Pro Gln Gly Glu Asp Thr Gly Ile Glu Gln Cys Asn Gly Ser Ser 
865                 870                 875                 880 


Ser Ser Ser Ile Pro Gly Ile Gln 
                885             


<210>  12
<211>  872
<212>  PRT
<213>  Mus musculus

<400>  12

Ile Leu Cys Ser Asn Ser Glu Phe Gln Ala Pro Phe Leu Thr Pro Ser 
1               5                   10                  15      


Leu Leu Pro Val Leu Val Leu Asn Ser Gln Glu Gln Lys Val Thr Pro 
            20                  25                  30          


Thr Pro Ser Lys Leu Glu Pro Ala Ser Leu Pro Asn Pro Leu Gly Thr 
        35                  40                  45              


Arg Gly Pro Trp Val Phe Asn Thr Cys Gly Ala Ser Gly Arg Ser Gly 
    50                  55                  60                  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Thr Gly Ser Ser Val Met 
65                  70                  75                  80  


Val Thr Val Gly Ala Ala Gly Pro Leu Lys Gly Val Gln Leu Trp Arg 
                85                  90                  95      


Ala Pro Asp Thr Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
            100                 105                 110         


Gly Lys Gly Ala Gln Asn His Leu Ser Arg Ala His Gly Ile Phe Leu 
        115                 120                 125             


Ser Ala Val Phe Phe Leu Arg Arg Gly Glu Pro Val Tyr Ile Leu Val 
    130                 135                 140                 


Gly Gln Gln Gly Gln Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
145                 150                 155                 160 


Leu Val Cys Leu Gly Glu Ser Gly Glu His Ala Thr Thr Tyr Gly Thr 
                165                 170                 175     


Glu Arg Ile Pro Gly Trp Arg Arg Trp Ala Gly Gly Gly Gly Gly Gly 
            180                 185                 190         


Gly Gly Ala Thr Ser Ile Phe Arg Leu Arg Ala Gly Glu Pro Glu Pro 
        195                 200                 205             


Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ser Tyr Arg Arg Arg Pro 
    210                 215                 220                 


Asp Arg Gly Arg Thr Gln Ala Val Pro Glu Arg Leu Glu Thr Arg Ala 
225                 230                 235                 240 


Ala Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly Gly Gly Ser 
                245                 250                 255     


Gly Trp Thr Ser Arg Ala His Ser Pro Gln Ala Gly Arg Ser Pro Arg 
            260                 265                 270         


Glu Gly Ala Glu Gly Gly Glu Gly Cys Ala Glu Ala Trp Ala Ala Leu 
        275                 280                 285             


Arg Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly Ala Cys Ala 
    290                 295                 300                 


Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Thr Ser Glu Ser 
305                 310                 315                 320 


Asp Leu Leu Trp Ala Asp Gly Glu Asp Gly Thr Ser Phe Val His Pro 
                325                 330                 335     


Ser Gly Glu Leu Tyr Leu Gln Pro Leu Ala Val Thr Glu Gly His Gly 
            340                 345                 350         


Glu Val Glu Ile Arg Lys His Pro Asn Cys Ser His Cys Pro Phe Lys 
        355                 360                 365             


Asp Cys Gln Trp Gln Ala Glu Leu Trp Thr Ala Glu Cys Thr Cys Pro 
    370                 375                 380                 


Glu Gly Thr Glu Leu Ala Val Asp Asn Val Thr Cys Met Asp Leu Pro 
385                 390                 395                 400 


Thr Thr Ala Ser Pro Leu Ile Leu Met Gly Ala Val Val Ala Ala Leu 
                405                 410                 415     


Ala Leu Ser Leu Leu Met Met Cys Ala Val Leu Ile Leu Val Asn Gln 
            420                 425                 430         


Lys Cys Gln Gly Leu Trp Gly Thr Arg Leu Pro Gly Pro Glu Leu Glu 
        435                 440                 445             


Leu Ser Lys Leu Arg Ser Ser Ala Ile Arg Thr Ala Pro Asn Pro Tyr 
    450                 455                 460                 


Tyr Cys Gln Val Gly Leu Ser Pro Ala Gln Pro Trp Pro Leu Pro Pro 
465                 470                 475                 480 


Gly Leu Thr Glu Val Ser Pro Ala Asn Val Thr Leu Leu Arg Ala Leu 
                485                 490                 495     


Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Leu Val Thr Gly Leu 
            500                 505                 510         


Pro Gly Asp Ser Ser Pro Leu Pro Val Ala Ile Lys Thr Leu Pro Glu 
        515                 520                 525             


Leu Cys Ser His Gln Asp Glu Leu Asp Phe Leu Met Glu Ala Leu Ile 
    530                 535                 540                 


Ile Ser Lys Phe Ser His Gln Asn Ile Val Arg Cys Val Gly Leu Ser 
545                 550                 555                 560 


Phe Arg Ser Ala Pro Arg Leu Ile Leu Leu Glu Leu Met Ser Gly Gly 
                565                 570                 575     


Asp Met Lys Ser Phe Leu Arg His Ser Arg Pro His Pro Gly Gln Leu 
            580                 585                 590         


Ala Pro Leu Thr Met Gln Asp Leu Leu Gln Leu Ala Gln Asp Ile Ala 
        595                 600                 605             


Gln Gly Cys His Tyr Leu Glu Glu Asn His Phe Ile His Arg Asp Ile 
    610                 615                 620                 


Ala Ala Arg Asn Cys Leu Leu Ser Cys Ser Gly Ala Ser Arg Val Ala 
625                 630                 635                 640 


Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr Gln Ala Ser Tyr 
                645                 650                 655     


Tyr Arg Lys Gly Gly Arg Thr Leu Leu Pro Val Lys Trp Met Pro Pro 
            660                 665                 670         


Glu Ala Leu Leu Glu Gly Leu Phe Thr Ser Lys Thr Asp Ser Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Tyr Met Pro Tyr 
    690                 695                 700                 


Pro Gly His Thr Asn Gln Glu Val Leu Asp Phe Ile Ala Thr Gly Asn 
705                 710                 715                 720 


Arg Met Asp Pro Pro Arg Asn Cys Pro Gly Pro Val Tyr Arg Ile Met 
                725                 730                 735     


Thr Gln Cys Trp Gln His Gln Pro Glu Leu Arg Pro Asp Phe Gly Ser 
            740                 745                 750         


Ile Leu Glu Arg Ile Gln Tyr Cys Thr Gln Asp Pro Asp Val Leu Asn 
        755                 760                 765             


Ser Pro Leu Pro Met Glu Pro Gly Pro Ile Leu Glu Glu Glu Glu Ala 
    770                 775                 780                 


Ser Arg Leu Gly Asn Arg Ser Leu Glu Gly Leu Arg Ser Pro Lys Pro 
785                 790                 795                 800 


Leu Glu Leu Ser Ser Gln Asn Leu Lys Ser Trp Gly Gly Gly Leu Leu 
                805                 810                 815     


Gly Ser Trp Leu Pro Ser Gly Leu Lys Thr Leu Lys Pro Arg Cys Leu 
            820                 825                 830         


Gln Pro Gln Asn Ile Trp Asn Pro Thr Tyr Gly Ser Trp Thr Pro Arg 
        835                 840                 845             


Gly Pro Gln Gly Glu Asp Thr Gly Ile Glu Gln Cys Asn Gly Ser Ser 
    850                 855                 860                 


Ser Ser Ser Ile Pro Gly Ile Gln 
865                 870         


<210>  13
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Gly Gly Gly Trp Thr Ser Arg Ala Pro Ser Pro Gln Ala Gly Arg 
        275                 280                 285             


Ser Leu Gln Glu Gly Ala Glu Gly Gly Gln Gly Cys Ser Glu Ala Trp 
    290                 295                 300                 


Ala Thr Leu Gly Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Ala Cys Thr Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Ala 
                325                 330                 335     


Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly Val Ser Phe 
            340                 345                 350         


Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala Val Thr Glu 
        355                 360                 365             


Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys Ser His Cys 
    370                 375                 380                 


Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu Ala Glu Cys 
385                 390                 395                 400 


Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val Thr Cys Met 
                405                 410                 415     


Asp Leu His Lys Pro Pro Gly Pro 
            420                 


<210>  14
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  14

Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
1               5                   10                  15      


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
            20                  25                  30          


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
        35                  40                  45              


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
    50                  55                  60                  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
65                  70                  75                  80  


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
                85                  90                  95      


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
            100                 105                 110         


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
        115                 120                 125             


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
    130                 135                 140                 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
145                 150                 155                 160 


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
                165                 170                 175     


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
        195                 200                 205             


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
    210                 215                 220                 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
225                 230                 235                 240 


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
                245                 250                 255     


Gly Gly Gly Gly Trp Thr Ser Arg Ala Pro Ser Pro Gln Ala Gly Arg 
            260                 265                 270         


Ser Leu Gln Glu Gly Ala Glu Gly Gly Gln Gly Cys Ser Glu Ala Trp 
        275                 280                 285             


Ala Thr Leu Gly Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly 
    290                 295                 300                 


Ala Cys Thr Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Ala 
305                 310                 315                 320 


Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly Val Ser Phe 
                325                 330                 335     


Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala Val Thr Glu 
            340                 345                 350         


Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys Ser His Cys 
        355                 360                 365             


Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu Ala Glu Cys 
    370                 375                 380                 


Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val Thr Cys Met 
385                 390                 395                 400 


Asp Leu His Lys Pro Pro Gly Pro 
                405             


<210>  15
<211>  421
<212>  PRT
<213>  Mus musculus

<400>  15

Met Gly Cys Ser His Arg Leu Leu Leu Trp Leu Gly Ala Ala Gly Thr 
1               5                   10                  15      


Ile Leu Cys Ser Asn Ser Glu Phe Gln Ala Pro Phe Leu Thr Pro Ser 
            20                  25                  30          


Leu Leu Pro Val Leu Val Leu Asn Ser Gln Glu Gln Lys Val Thr Pro 
        35                  40                  45              


Thr Pro Ser Lys Leu Glu Pro Ala Ser Leu Pro Asn Pro Leu Gly Thr 
    50                  55                  60                  


Arg Gly Pro Trp Val Phe Asn Thr Cys Gly Ala Ser Gly Arg Ser Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Thr Gly Ser Ser Val Met 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Pro Leu Lys Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Ala Pro Asp Thr Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Gln Asn His Leu Ser Arg Ala His Gly Ile Phe Leu 
    130                 135                 140                 


Ser Ala Val Phe Phe Leu Arg Arg Gly Glu Pro Val Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Gln Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Gly Glu His Ala Thr Thr Tyr Gly Thr 
            180                 185                 190         


Glu Arg Ile Pro Gly Trp Arg Arg Trp Ala Gly Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Gly Ala Thr Ser Ile Phe Arg Leu Arg Ala Gly Glu Pro Glu Pro 
    210                 215                 220                 


Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ser Tyr Arg Arg Arg Pro 
225                 230                 235                 240 


Asp Arg Gly Arg Thr Gln Ala Val Pro Glu Arg Leu Glu Thr Arg Ala 
                245                 250                 255     


Ala Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly Gly Gly Ser 
            260                 265                 270         


Gly Trp Thr Ser Arg Ala His Ser Pro Gln Ala Gly Arg Ser Pro Arg 
        275                 280                 285             


Glu Gly Ala Glu Gly Gly Glu Gly Cys Ala Glu Ala Trp Ala Ala Leu 
    290                 295                 300                 


Arg Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly Ala Cys Ala 
305                 310                 315                 320 


Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Thr Ser Glu Ser 
                325                 330                 335     


Asp Leu Leu Trp Ala Asp Gly Glu Asp Gly Thr Ser Phe Val His Pro 
            340                 345                 350         


Ser Gly Glu Leu Tyr Leu Gln Pro Leu Ala Val Thr Glu Gly His Gly 
        355                 360                 365             


Glu Val Glu Ile Arg Lys His Pro Asn Cys Ser His Cys Pro Phe Lys 
    370                 375                 380                 


Asp Cys Gln Trp Gln Ala Glu Leu Trp Thr Ala Glu Cys Thr Cys Pro 
385                 390                 395                 400 


Glu Gly Thr Glu Leu Ala Val Asp Asn Val Thr Cys Met Asp Leu Pro 
                405                 410                 415     


Thr Thr Ala Ser Pro 
            420     


<210>  16
<211>  405
<212>  PRT
<213>  Mus musculus

<400>  16

Ile Leu Cys Ser Asn Ser Glu Phe Gln Ala Pro Phe Leu Thr Pro Ser 
1               5                   10                  15      


Leu Leu Pro Val Leu Val Leu Asn Ser Gln Glu Gln Lys Val Thr Pro 
            20                  25                  30          


Thr Pro Ser Lys Leu Glu Pro Ala Ser Leu Pro Asn Pro Leu Gly Thr 
        35                  40                  45              


Arg Gly Pro Trp Val Phe Asn Thr Cys Gly Ala Ser Gly Arg Ser Gly 
    50                  55                  60                  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Thr Gly Ser Ser Val Met 
65                  70                  75                  80  


Val Thr Val Gly Ala Ala Gly Pro Leu Lys Gly Val Gln Leu Trp Arg 
                85                  90                  95      


Ala Pro Asp Thr Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
            100                 105                 110         


Gly Lys Gly Ala Gln Asn His Leu Ser Arg Ala His Gly Ile Phe Leu 
        115                 120                 125             


Ser Ala Val Phe Phe Leu Arg Arg Gly Glu Pro Val Tyr Ile Leu Val 
    130                 135                 140                 


Gly Gln Gln Gly Gln Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
145                 150                 155                 160 


Leu Val Cys Leu Gly Glu Ser Gly Glu His Ala Thr Thr Tyr Gly Thr 
                165                 170                 175     


Glu Arg Ile Pro Gly Trp Arg Arg Trp Ala Gly Gly Gly Gly Gly Gly 
            180                 185                 190         


Gly Gly Ala Thr Ser Ile Phe Arg Leu Arg Ala Gly Glu Pro Glu Pro 
        195                 200                 205             


Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ser Tyr Arg Arg Arg Pro 
    210                 215                 220                 


Asp Arg Gly Arg Thr Gln Ala Val Pro Glu Arg Leu Glu Thr Arg Ala 
225                 230                 235                 240 


Ala Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly Gly Gly Ser 
                245                 250                 255     


Gly Trp Thr Ser Arg Ala His Ser Pro Gln Ala Gly Arg Ser Pro Arg 
            260                 265                 270         


Glu Gly Ala Glu Gly Gly Glu Gly Cys Ala Glu Ala Trp Ala Ala Leu 
        275                 280                 285             


Arg Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly Ala Cys Ala 
    290                 295                 300                 


Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Thr Ser Glu Ser 
305                 310                 315                 320 


Asp Leu Leu Trp Ala Asp Gly Glu Asp Gly Thr Ser Phe Val His Pro 
                325                 330                 335     


Ser Gly Glu Leu Tyr Leu Gln Pro Leu Ala Val Thr Glu Gly His Gly 
            340                 345                 350         


Glu Val Glu Ile Arg Lys His Pro Asn Cys Ser His Cys Pro Phe Lys 
        355                 360                 365             


Asp Cys Gln Trp Gln Ala Glu Leu Trp Thr Ala Glu Cys Thr Cys Pro 
    370                 375                 380                 


Glu Gly Thr Glu Leu Ala Val Asp Asn Val Thr Cys Met Asp Leu Pro 
385                 390                 395                 400 


Thr Thr Ala Ser Pro 
                405 


<210>  17
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  18
<211>  228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  19
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  20
<211>  1620
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  21
<211>  1602
<212>  PRT
<213>  Homo sapiens

<400>  21

Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro Ala Ala 
1               5                   10                  15      


Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg Leu Gln 
            20                  25                  30          


Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe Arg Val 
        35                  40                  45              


Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu Lys Ala 
    50                  55                  60                  


Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala Pro Leu 
65                  70                  75                  80  


Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala Gly Ser 
                85                  90                  95      


Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys Gly Gly 
            100                 105                 110         


Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu Leu Gly 
        115                 120                 125             


Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu Ala Ala 
    130                 135                 140                 


Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp Trp Ile 
145                 150                 155                 160 


Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu Lys Lys 
                165                 170                 175     


Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile Arg Ala 
            180                 185                 190         


Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His Ser Ser 
        195                 200                 205             


Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr Phe Thr 
    210                 215                 220                 


Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu Ser His 
225                 230                 235                 240 


Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys Glu Leu 
                245                 250                 255     


Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp Ser Trp 
            260                 265                 270         


Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu Asp Gly 
        275                 280                 285             


Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe Leu Leu 
    290                 295                 300                 


Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro Trp Met 
305                 310                 315                 320 


Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His Arg His 
                325                 330                 335     


Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His Asn Glu 
            340                 345                 350         


Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His Gly Trp 
        355                 360                 365             


Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe Arg Val 
    370                 375                 380                 


Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala Val Asp 
385                 390                 395                 400 


Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly Ser Lys 
                405                 410                 415     


Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val Leu Gln 
            420                 425                 430         


Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly Glu Asp 
        435                 440                 445             


Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys Asn Phe 
    450                 455                 460                 


Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro His Thr 
465                 470                 475                 480 


Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln Asp His 
                485                 490                 495     


Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala Ser Glu 
            500                 505                 510         


Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys Ser Ser 
        515                 520                 525             


Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu Arg Gly 
    530                 535                 540                 


Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu Gln Gly 
545                 550                 555                 560 


Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu Trp Gln 
                565                 570                 575     


Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp Leu Gln 
            580                 585                 590         


Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala Phe Asp 
        595                 600                 605             


Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly Glu Asp 
    610                 615                 620                 


Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe Glu Arg 
625                 630                 635                 640 


Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg Gln Thr 
                645                 650                 655     


Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys Gly Ala 
            660                 665                 670         


Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala Tyr Gln 
        675                 680                 685             


Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu Lys Gly 
    690                 695                 700                 


Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile Ser Gly 
705                 710                 715                 720 


Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met Arg Ser 
                725                 730                 735     


His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp Asp Met 
            740                 745                 750         


Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro Ser Thr 
        755                 760                 765             


Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val Ile Glu 
    770                 775                 780                 


Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly Gly Gly 
785                 790                 795                 800 


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp Gly Val 
                805                 810                 815     


Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala Tyr Gly 
            820                 825                 830         


Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn Ser Ser 
        835                 840                 845             


Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly Gly Gly 
    850                 855                 860                 


Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu Gln Glu 
865                 870                 875                 880 


Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys Trp Gly 
                885                 890                 895     


Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys Ser Ser 
            900                 905                 910         


Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser Asn Asn 
        915                 920                 925             


Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser Pro Leu 
    930                 935                 940                 


Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His Gly Glu 
945                 950                 955                 960 


Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val Asp Glu 
                965                 970                 975     


Cys His Met Asp Pro Glu Ser His Lys Val Ile Cys Phe Cys Asp His 
            980                 985                 990         


Gly Thr Val Leu Ala Glu Asp Gly  Val Ser Cys Ile Val  Ser Pro Thr 
        995                 1000                 1005             


Pro Glu  Pro His Leu Pro Leu  Ser Leu Ile Leu Ser  Val Val Thr 
    1010                 1015                 1020             


Ser Ala  Leu Val Ala Ala Leu  Val Leu Ala Phe Ser  Gly Ile Met 
    1025                 1030                 1035             


Ile Val  Tyr Arg Arg Lys His  Gln Glu Leu Gln Ala  Met Gln Met 
    1040                 1045                 1050             


Glu Leu  Gln Ser Pro Glu Tyr  Lys Leu Ser Lys Leu  Arg Thr Ser 
    1055                 1060                 1065             


Thr Ile  Met Thr Asp Tyr Asn  Pro Asn Tyr Cys Phe  Ala Gly Lys 
    1070                 1075                 1080             


Thr Ser  Ser Ile Ser Asp Leu  Lys Glu Val Pro Arg  Lys Asn Ile 
    1085                 1090                 1095             


Thr Leu  Ile Arg Gly Leu Gly  His Gly Ala Phe Gly  Glu Val Tyr 
    1100                 1105                 1110             


Glu Gly  Gln Val Ser Gly Met  Pro Asn Asp Pro Ser  Pro Leu Gln 
    1115                 1120                 1125             


Val Ala  Val Lys Thr Leu Pro  Glu Val Cys Ser Glu  Gln Asp Glu 
    1130                 1135                 1140             


Leu Asp  Phe Leu Met Glu Ala  Leu Ile Ile Ser Lys  Phe Asn His 
    1145                 1150                 1155             


Gln Asn  Ile Val Arg Cys Ile  Gly Val Ser Leu Gln  Ser Leu Pro 
    1160                 1165                 1170             


Arg Phe  Ile Leu Leu Glu Leu  Met Ala Gly Gly Asp  Leu Lys Ser 
    1175                 1180                 1185             


Phe Leu  Arg Glu Thr Arg Pro  Arg Pro Ser Gln Pro  Ser Ser Leu 
    1190                 1195                 1200             


Ala Met  Leu Asp Leu Leu His  Val Ala Arg Asp Ile  Ala Cys Gly 
    1205                 1210                 1215             


Cys Gln  Tyr Leu Glu Glu Asn  His Phe Ile His Arg  Asp Ile Ala 
    1220                 1225                 1230             


Ala Arg  Asn Cys Leu Leu Thr  Cys Pro Gly Pro Gly  Arg Val Ala 
    1235                 1240                 1245             


Lys Ile  Gly Asp Phe Gly Met  Ala Arg Asp Ile Tyr  Arg Ala Ser 
    1250                 1255                 1260             


Tyr Tyr  Arg Lys Gly Gly Cys  Ala Met Leu Pro Val  Lys Trp Met 
    1265                 1270                 1275             


Pro Pro  Glu Ala Phe Met Glu  Gly Ile Phe Thr Ser  Lys Thr Asp 
    1280                 1285                 1290             


Thr Trp  Ser Phe Gly Val Leu  Leu Trp Glu Ile Phe  Ser Leu Gly 
    1295                 1300                 1305             


Tyr Met  Pro Tyr Pro Ser Lys  Ser Asn Gln Glu Val  Leu Glu Phe 
    1310                 1315                 1320             


Val Thr  Ser Gly Gly Arg Met  Asp Pro Pro Lys Asn  Cys Pro Gly 
    1325                 1330                 1335             


Pro Val  Tyr Arg Ile Met Thr  Gln Cys Trp Gln His  Gln Pro Glu 
    1340                 1345                 1350             


Asp Arg  Pro Asn Phe Ala Ile  Ile Leu Glu Arg Ile  Glu Tyr Cys 
    1355                 1360                 1365             


Thr Gln  Asp Pro Asp Val Ile  Asn Thr Ala Leu Pro  Ile Glu Tyr 
    1370                 1375                 1380             


Gly Pro  Leu Val Glu Glu Glu  Glu Lys Val Pro Val  Arg Pro Lys 
    1385                 1390                 1395             


Asp Pro  Glu Gly Val Pro Pro  Leu Leu Val Ser Gln  Gln Ala Lys 
    1400                 1405                 1410             


Arg Glu  Glu Glu Arg Ser Pro  Ala Ala Pro Pro Pro  Leu Pro Thr 
    1415                 1420                 1425             


Thr Ser  Ser Gly Lys Ala Ala  Lys Lys Pro Thr Ala  Ala Glu Ile 
    1430                 1435                 1440             


Ser Val  Arg Val Pro Arg Gly  Pro Ala Val Glu Gly  Gly His Val 
    1445                 1450                 1455             


Asn Met  Ala Phe Ser Gln Ser  Asn Pro Pro Ser Glu  Leu His Lys 
    1460                 1465                 1470             


Val His  Gly Ser Arg Asn Lys  Pro Thr Ser Leu Trp  Asn Pro Thr 
    1475                 1480                 1485             


Tyr Gly  Ser Trp Phe Thr Glu  Lys Pro Thr Lys Lys  Asn Asn Pro 
    1490                 1495                 1500             


Ile Ala  Lys Lys Glu Pro His  Asp Arg Gly Asn Leu  Gly Leu Glu 
    1505                 1510                 1515             


Gly Ser  Cys Thr Val Pro Pro  Asn Val Ala Thr Gly  Arg Leu Pro 
    1520                 1525                 1530             


Gly Ala  Ser Leu Leu Leu Glu  Pro Ser Ser Leu Thr  Ala Asn Met 
    1535                 1540                 1545             


Lys Glu  Val Pro Leu Phe Arg  Leu Arg His Phe Pro  Cys Gly Asn 
    1550                 1555                 1560             


Val Asn  Tyr Gly Tyr Gln Gln  Gln Gly Leu Pro Leu  Glu Ala Ala 
    1565                 1570                 1575             


Thr Ala  Pro Gly Ala Gly His  Tyr Glu Asp Thr Ile  Leu Lys Ser 
    1580                 1585                 1590             


Lys Asn  Ser Met Asn Gln Pro  Gly Pro 
    1595                 1600         


<210>  22
<211>  659
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  22

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Gly Gly Gly Trp Thr Ser Arg Ala Pro Ser Pro Gln Ala Gly Arg 
        275                 280                 285             


Ser Leu Gln Glu Gly Ala Glu Gly Gly Gln Gly Cys Ser Glu Ala Trp 
    290                 295                 300                 


Ala Thr Leu Gly Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Ala Cys Thr Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Ala 
                325                 330                 335     


Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly Val Ser Phe 
            340                 345                 350         


Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala Val Thr Glu 
        355                 360                 365             


Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys Ser His Cys 
    370                 375                 380                 


Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu Ala Glu Cys 
385                 390                 395                 400 


Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val Thr Cys Met 
                405                 410                 415     


Asp Leu His Lys Pro Pro Gly Pro Leu Gly Ser Glu Pro Lys Ser Ser 
            420                 425                 430         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        435                 440                 445             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    450                 455                 460                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
465                 470                 475                 480 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                485                 490                 495     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            500                 505                 510         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        515                 520                 525             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    530                 535                 540                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
545                 550                 555                 560 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                565                 570                 575     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            580                 585                 590         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        595                 600                 605             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    610                 615                 620                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
625                 630                 635                 640 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                645                 650                 655     


Pro Gly Lys 
            


<210>  23
<211>  643
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  23

Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
1               5                   10                  15      


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
            20                  25                  30          


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
        35                  40                  45              


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
    50                  55                  60                  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
65                  70                  75                  80  


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
                85                  90                  95      


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
            100                 105                 110         


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
        115                 120                 125             


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
    130                 135                 140                 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
145                 150                 155                 160 


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
                165                 170                 175     


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
        195                 200                 205             


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
    210                 215                 220                 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
225                 230                 235                 240 


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
                245                 250                 255     


Gly Gly Gly Gly Trp Thr Ser Arg Ala Pro Ser Pro Gln Ala Gly Arg 
            260                 265                 270         


Ser Leu Gln Glu Gly Ala Glu Gly Gly Gln Gly Cys Ser Glu Ala Trp 
        275                 280                 285             


Ala Thr Leu Gly Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly 
    290                 295                 300                 


Ala Cys Thr Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Ala 
305                 310                 315                 320 


Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly Val Ser Phe 
                325                 330                 335     


Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala Val Thr Glu 
            340                 345                 350         


Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys Ser His Cys 
        355                 360                 365             


Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu Ala Glu Cys 
    370                 375                 380                 


Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val Thr Cys Met 
385                 390                 395                 400 


Asp Leu His Lys Pro Pro Gly Pro Leu Gly Ser Glu Pro Lys Ser Ser 
                405                 410                 415     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            420                 425                 430         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        435                 440                 445             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    450                 455                 460                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
465                 470                 475                 480 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                485                 490                 495     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            500                 505                 510         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        515                 520                 525             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    530                 535                 540                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
545                 550                 555                 560 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                565                 570                 575     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            580                 585                 590         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        595                 600                 605             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    610                 615                 620                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
625                 630                 635                 640 


Pro Gly Lys 
            


<210>  24
<211>  1272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  24

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Ser Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Gly Ser  Glu Pro Lys Ser Ser  Asp Lys Thr His Thr  Cys Pro Pro 
    1040                 1045                 1050             


Cys Pro  Ala Pro Glu Leu Leu  Gly Gly Pro Ser Val  Phe Leu Phe 
    1055                 1060                 1065             


Pro Pro  Lys Pro Lys Asp Thr  Leu Met Ile Ser Arg  Thr Pro Glu 
    1070                 1075                 1080             


Val Thr  Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
    1085                 1090                 1095             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1100                 1105                 1110             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1115                 1120                 1125             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu 
    1130                 1135                 1140             


Tyr Lys  Cys Lys Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1145                 1150                 1155             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1160                 1165                 1170             


Tyr Thr  Leu Pro Pro Ser Arg  Asp Glu Leu Thr Lys  Asn Gln Val 
    1175                 1180                 1185             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1190                 1195                 1200             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1205                 1210                 1215             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1220                 1225                 1230             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1235                 1240                 1245             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1250                 1255                 1260             


Lys Ser  Leu Ser Leu Ser Pro  Gly Lys 
    1265                 1270         


<210>  25
<211>  1254
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  25

Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro Ala Ala 
1               5                   10                  15      


Gly Ser Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg Leu Gln 
            20                  25                  30          


Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe Arg Val 
        35                  40                  45              


Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu Lys Ala 
    50                  55                  60                  


Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala Pro Leu 
65                  70                  75                  80  


Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala Gly Ser 
                85                  90                  95      


Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys Gly Gly 
            100                 105                 110         


Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu Leu Gly 
        115                 120                 125             


Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu Ala Ala 
    130                 135                 140                 


Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp Trp Ile 
145                 150                 155                 160 


Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu Lys Lys 
                165                 170                 175     


Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile Arg Ala 
            180                 185                 190         


Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His Ser Ser 
        195                 200                 205             


Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr Phe Thr 
    210                 215                 220                 


Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu Ser His 
225                 230                 235                 240 


Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys Glu Leu 
                245                 250                 255     


Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp Ser Trp 
            260                 265                 270         


Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu Asp Gly 
        275                 280                 285             


Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe Leu Leu 
    290                 295                 300                 


Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro Trp Met 
305                 310                 315                 320 


Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His Arg His 
                325                 330                 335     


Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His Asn Glu 
            340                 345                 350         


Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His Gly Trp 
        355                 360                 365             


Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe Arg Val 
    370                 375                 380                 


Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala Val Asp 
385                 390                 395                 400 


Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly Ser Lys 
                405                 410                 415     


Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val Leu Gln 
            420                 425                 430         


Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly Glu Asp 
        435                 440                 445             


Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys Asn Phe 
    450                 455                 460                 


Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro His Thr 
465                 470                 475                 480 


Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln Asp His 
                485                 490                 495     


Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala Ser Glu 
            500                 505                 510         


Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys Ser Ser 
        515                 520                 525             


Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu Arg Gly 
    530                 535                 540                 


Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu Gln Gly 
545                 550                 555                 560 


Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu Trp Gln 
                565                 570                 575     


Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp Leu Gln 
            580                 585                 590         


Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala Phe Asp 
        595                 600                 605             


Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly Glu Asp 
    610                 615                 620                 


Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe Glu Arg 
625                 630                 635                 640 


Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg Gln Thr 
                645                 650                 655     


Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys Gly Ala 
            660                 665                 670         


Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala Tyr Gln 
        675                 680                 685             


Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu Lys Gly 
    690                 695                 700                 


Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile Ser Gly 
705                 710                 715                 720 


Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met Arg Ser 
                725                 730                 735     


His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp Asp Met 
            740                 745                 750         


Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro Ser Thr 
        755                 760                 765             


Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val Ile Glu 
    770                 775                 780                 


Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly Gly Gly 
785                 790                 795                 800 


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp Gly Val 
                805                 810                 815     


Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala Tyr Gly 
            820                 825                 830         


Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn Ser Ser 
        835                 840                 845             


Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly Gly Gly 
    850                 855                 860                 


Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu Gln Glu 
865                 870                 875                 880 


Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys Trp Gly 
                885                 890                 895     


Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys Ser Ser 
            900                 905                 910         


Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser Asn Asn 
        915                 920                 925             


Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser Pro Leu 
    930                 935                 940                 


Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His Gly Glu 
945                 950                 955                 960 


Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val Asp Glu 
                965                 970                 975     


Cys His Met Asp Pro Glu Ser His Lys Val Ile Cys Phe Cys Asp His 
            980                 985                 990         


Gly Thr Val Leu Ala Glu Asp Gly  Val Ser Cys Ile Val  Ser Pro Thr 
        995                 1000                 1005             


Pro Glu  Pro His Leu Pro Leu  Ser Leu Ile Leu Ser  Gly Ser Glu 
    1010                 1015                 1020             


Pro Lys  Ser Ser Asp Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala 
    1025                 1030                 1035             


Pro Glu  Leu Leu Gly Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys 
    1040                 1045                 1050             


Pro Lys  Asp Thr Leu Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys 
    1055                 1060                 1065             


Val Val  Val Asp Val Ser His  Glu Asp Pro Glu Val  Lys Phe Asn 
    1070                 1075                 1080             


Trp Tyr  Val Asp Gly Val Glu  Val His Asn Ala Lys  Thr Lys Pro 
    1085                 1090                 1095             


Arg Glu  Glu Gln Tyr Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu 
    1100                 1105                 1110             


Thr Val  Leu His Gln Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys 
    1115                 1120                 1125             


Lys Val  Ser Asn Lys Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile 
    1130                 1135                 1140             


Ser Lys  Ala Lys Gly Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu 
    1145                 1150                 1155             


Pro Pro  Ser Arg Asp Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr 
    1160                 1165                 1170             


Cys Leu  Val Lys Gly Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp 
    1175                 1180                 1185             


Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro 
    1190                 1195                 1200             


Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr 
    1205                 1210                 1215             


Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser 
    1220                 1225                 1230             


Val Met  His Glu Ala Leu His  Asn His Tyr Thr Gln  Lys Ser Leu 
    1235                 1240                 1245             


Ser Leu  Ser Pro Gly Lys 
    1250                 


<210>  26
<211>  655
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  26

Met Gly Cys Ser His Arg Leu Leu Leu Trp Leu Gly Ala Ala Gly Thr 
1               5                   10                  15      


Ile Leu Cys Ser Asn Ser Glu Phe Gln Thr Pro Phe Leu Thr Pro Ser 
            20                  25                  30          


Leu Leu Pro Val Leu Val Leu Asn Ser Gln Glu Gln Lys Val Thr Pro 
        35                  40                  45              


Thr Pro Ser Lys Leu Glu Pro Ala Ser Leu Pro Asn Pro Leu Gly Thr 
    50                  55                  60                  


Arg Gly Pro Trp Val Phe Asn Thr Cys Gly Ala Ser Gly Arg Ser Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Thr Gly Ser Ser Val Met 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Pro Leu Lys Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Asp Thr Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Gln Asn His Leu Ser Arg Ala His Gly Ile Phe Leu 
    130                 135                 140                 


Ser Ala Val Phe Phe Leu Arg Arg Gly Glu Pro Val Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Gln Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Gly Glu His Ala Thr Thr Tyr Gly Thr 
            180                 185                 190         


Glu Arg Ile Pro Gly Trp Arg Arg Trp Ala Gly Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Gly Ala Thr Ser Ile Phe Arg Leu Arg Ala Gly Glu Pro Glu Pro 
    210                 215                 220                 


Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ser Tyr Arg Arg Arg Pro 
225                 230                 235                 240 


Asp Arg Gly Arg Thr Gln Ala Val Pro Glu Arg Leu Glu Thr Arg Ala 
                245                 250                 255     


Ala Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly Gly Gly Ser 
            260                 265                 270         


Gly Trp Thr Ser Arg Ala His Ser Pro Gln Ala Gly Arg Ser Pro Arg 
        275                 280                 285             


Glu Gly Ala Glu Gly Gly Glu Gly Cys Ala Glu Ala Trp Ala Ala Leu 
    290                 295                 300                 


Arg Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly Ala Cys Ala 
305                 310                 315                 320 


Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Thr Ser Glu Ser 
                325                 330                 335     


Asp Leu Leu Trp Ala Asp Gly Glu Asp Gly Thr Ser Phe Val His Pro 
            340                 345                 350         


Ser Gly Glu Leu Tyr Leu Gln Pro Leu Ala Val Thr Glu Gly His Gly 
        355                 360                 365             


Glu Val Glu Ile Arg Lys His Pro Asn Cys Ser His Cys Pro Phe Lys 
    370                 375                 380                 


Asp Cys Gln Trp Gln Ala Glu Leu Trp Thr Ala Glu Cys Thr Cys Pro 
385                 390                 395                 400 


Glu Gly Thr Glu Leu Ala Val Asp Asn Val Thr Cys Met Asp Leu Pro 
                405                 410                 415     


Thr Thr Ala Ser Pro Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            420                 425                 430         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        435                 440                 445             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    450                 455                 460                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
465                 470                 475                 480 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                485                 490                 495     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            500                 505                 510         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        515                 520                 525             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    530                 535                 540                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
545                 550                 555                 560 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                565                 570                 575     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            580                 585                 590         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        595                 600                 605             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    610                 615                 620                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
625                 630                 635                 640 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650                 655 


<210>  27
<211>  639
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  27

Ile Leu Cys Ser Asn Ser Glu Phe Gln Thr Pro Phe Leu Thr Pro Ser 
1               5                   10                  15      


Leu Leu Pro Val Leu Val Leu Asn Ser Gln Glu Gln Lys Val Thr Pro 
            20                  25                  30          


Thr Pro Ser Lys Leu Glu Pro Ala Ser Leu Pro Asn Pro Leu Gly Thr 
        35                  40                  45              


Arg Gly Pro Trp Val Phe Asn Thr Cys Gly Ala Ser Gly Arg Ser Gly 
    50                  55                  60                  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Thr Gly Ser Ser Val Met 
65                  70                  75                  80  


Val Thr Val Gly Ala Ala Gly Pro Leu Lys Gly Val Gln Leu Trp Arg 
                85                  90                  95      


Val Pro Asp Thr Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
            100                 105                 110         


Gly Lys Gly Ala Gln Asn His Leu Ser Arg Ala His Gly Ile Phe Leu 
        115                 120                 125             


Ser Ala Val Phe Phe Leu Arg Arg Gly Glu Pro Val Tyr Ile Leu Val 
    130                 135                 140                 


Gly Gln Gln Gly Gln Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
145                 150                 155                 160 


Leu Val Cys Leu Gly Glu Ser Gly Glu His Ala Thr Thr Tyr Gly Thr 
                165                 170                 175     


Glu Arg Ile Pro Gly Trp Arg Arg Trp Ala Gly Gly Gly Gly Gly Gly 
            180                 185                 190         


Gly Gly Ala Thr Ser Ile Phe Arg Leu Arg Ala Gly Glu Pro Glu Pro 
        195                 200                 205             


Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ser Tyr Arg Arg Arg Pro 
    210                 215                 220                 


Asp Arg Gly Arg Thr Gln Ala Val Pro Glu Arg Leu Glu Thr Arg Ala 
225                 230                 235                 240 


Ala Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly Gly Gly Ser 
                245                 250                 255     


Gly Trp Thr Ser Arg Ala His Ser Pro Gln Ala Gly Arg Ser Pro Arg 
            260                 265                 270         


Glu Gly Ala Glu Gly Gly Glu Gly Cys Ala Glu Ala Trp Ala Ala Leu 
        275                 280                 285             


Arg Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly Ala Cys Ala 
    290                 295                 300                 


Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Thr Ser Glu Ser 
305                 310                 315                 320 


Asp Leu Leu Trp Ala Asp Gly Glu Asp Gly Thr Ser Phe Val His Pro 
                325                 330                 335     


Ser Gly Glu Leu Tyr Leu Gln Pro Leu Ala Val Thr Glu Gly His Gly 
            340                 345                 350         


Glu Val Glu Ile Arg Lys His Pro Asn Cys Ser His Cys Pro Phe Lys 
        355                 360                 365             


Asp Cys Gln Trp Gln Ala Glu Leu Trp Thr Ala Glu Cys Thr Cys Pro 
    370                 375                 380                 


Glu Gly Thr Glu Leu Ala Val Asp Asn Val Thr Cys Met Asp Leu Pro 
385                 390                 395                 400 


Thr Thr Ala Ser Pro Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                405                 410                 415     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            420                 425                 430         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        435                 440                 445             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    450                 455                 460                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
465                 470                 475                 480 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                485                 490                 495     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            500                 505                 510         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        515                 520                 525             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    530                 535                 540                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
545                 550                 555                 560 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                565                 570                 575     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            580                 585                 590         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        595                 600                 605             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    610                 615                 620                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630                 635                 


<210>  28
<211>  597
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  28

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Asp Ala Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly 
        275                 280                 285             


Val Ser Phe Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala 
    290                 295                 300                 


Val Thr Glu Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys 
305                 310                 315                 320 


Ser His Cys Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu 
                325                 330                 335     


Ala Glu Cys Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val 
            340                 345                 350         


Thr Cys Met Asp Leu His Lys Pro Pro Gly Pro Gly Ser Glu Pro Lys 
        355                 360                 365             


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    370                 375                 380                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
385                 390                 395                 400 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                405                 410                 415     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            420                 425                 430         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        435                 440                 445             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    450                 455                 460                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
465                 470                 475                 480 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                485                 490                 495     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            500                 505                 510         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        515                 520                 525             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    530                 535                 540                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
545                 550                 555                 560 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                565                 570                 575     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            580                 585                 590         


Leu Ser Pro Gly Lys 
        595         


<210>  29
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  29

Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
1               5                   10                  15      


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
            20                  25                  30          


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
        35                  40                  45              


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
    50                  55                  60                  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
65                  70                  75                  80  


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
                85                  90                  95      


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
            100                 105                 110         


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
        115                 120                 125             


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
    130                 135                 140                 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
145                 150                 155                 160 


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
                165                 170                 175     


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
        195                 200                 205             


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
    210                 215                 220                 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
225                 230                 235                 240 


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
                245                 250                 255     


Gly Asp Ala Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly 
            260                 265                 270         


Val Ser Phe Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala 
        275                 280                 285             


Val Thr Glu Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys 
    290                 295                 300                 


Ser His Cys Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu 
305                 310                 315                 320 


Ala Glu Cys Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val 
                325                 330                 335     


Thr Cys Met Asp Leu His Lys Pro Pro Gly Pro Gly Ser Glu Pro Lys 
            340                 345                 350         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        355                 360                 365             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    370                 375                 380                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
385                 390                 395                 400 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                405                 410                 415     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            420                 425                 430         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        435                 440                 445             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    450                 455                 460                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
465                 470                 475                 480 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                485                 490                 495     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            500                 505                 510         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        515                 520                 525             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    530                 535                 540                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
545                 550                 555                 560 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                565                 570                 575     


Leu Ser Pro Gly Lys 
            580     


<210>  30
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Asp Ala Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly 
        275                 280                 285             


Val Ser Phe Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala 
    290                 295                 300                 


Val Thr Glu Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys 
305                 310                 315                 320 


Ser His Cys Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu 
                325                 330                 335     


Ala Glu Cys Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val 
            340                 345                 350         


Thr Cys Met Asp Leu His Lys Pro Pro Gly Pro 
        355                 360             


<210>  31
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  31

Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
1               5                   10                  15      


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
            20                  25                  30          


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
        35                  40                  45              


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
    50                  55                  60                  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
65                  70                  75                  80  


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
                85                  90                  95      


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
            100                 105                 110         


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
        115                 120                 125             


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
    130                 135                 140                 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
145                 150                 155                 160 


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
                165                 170                 175     


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
        195                 200                 205             


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
    210                 215                 220                 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
225                 230                 235                 240 


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
                245                 250                 255     


Gly Asp Ala Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly 
            260                 265                 270         


Val Ser Phe Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala 
        275                 280                 285             


Val Thr Glu Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys 
    290                 295                 300                 


Ser His Cys Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu 
305                 310                 315                 320 


Ala Glu Cys Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val 
                325                 330                 335     


Thr Cys Met Asp Leu His Lys Pro Pro Gly Pro 
            340                 345         


<210>  32
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  32

Met Trp Leu Thr Lys Pro Ser Thr Pro Val Ser Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Leu Ser Pro Pro Gly Thr Gln Gly Arg Pro Gln Arg Ser 
            20                  25                  30          


Leu Ala Ala Arg Val Ala Glu Leu Arg Pro Glu Leu Phe Leu Pro Val 
        35                  40                  45              


Thr Gly Thr Arg Leu Pro Pro Arg Ala Ser Arg Ser Thr Glu Ile Phe 
    50                  55                  60                  


Pro Arg Asp Leu Thr Leu Lys Asp Lys Phe Ile Lys His Phe Thr Gly 
65                  70                  75                  80  


Pro Val Thr Phe Ser Ala Glu Cys Ser Lys His Phe His Arg Leu Tyr 
                85                  90                  95      


His Asn Thr Arg Asp Cys Ser Thr Pro Ala Tyr Tyr Lys Arg Cys Ala 
            100                 105                 110         


Arg Leu Leu Thr Arg Leu Ala Val Ser Pro Leu Cys Ser Gln Thr 
        115                 120                 125         


<210>  33
<211>  100
<212>  PRT
<213>  Mus musculus

<400>  33

Arg Pro Gln Arg Ser Leu Ala Ala Arg Val Ala Glu Leu Arg Pro Glu 
1               5                   10                  15      


Leu Phe Leu Pro Val Thr Gly Thr Arg Leu Pro Pro Arg Ala Ser Arg 
            20                  25                  30          


Ser Thr Glu Ile Phe Pro Arg Asp Leu Thr Leu Lys Asp Lys Phe Ile 
        35                  40                  45              


Lys His Phe Thr Gly Pro Val Thr Phe Ser Ala Glu Cys Ser Lys His 
    50                  55                  60                  


Phe His Arg Leu Tyr His Asn Thr Arg Asp Cys Ser Thr Pro Ala Tyr 
65                  70                  75                  80  


Tyr Lys Arg Cys Ala Arg Leu Leu Thr Arg Leu Ala Val Ser Pro Leu 
                85                  90                  95      


Cys Ser Gln Thr 
            100 


