                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF WARWICK
 
<120>  INHIBITOR FOR TREATMENT OF HCV

<130>  N118527A-WO

<150>  GB1305503.3
<151>  2013-03-26

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  48
<212>  RNA
<213>  Hepatitis C virus

<400>  1
cagcggggga gacauauauc acagccuguc ucgugcccga ccccgcug                    48


<210>  2
<211>  48
<212>  RNA
<213>  Hepatitis C virus

<400>  2
cggcgggggc gacauuuuuc acagcguguc gcgcgcccga ccccgcuc                    48


<210>  3
<211>  27
<212>  RNA
<213>  Hepatitis C virus

<400>  3
ucacggcuag cugugaaagg uccguga                                           27


<210>  4
<211>  12
<212>  RNA
<213>  Hepatitis C virus

<400>  4
uauaucacag cc                                                           12


<210>  5
<211>  12
<212>  RNA
<213>  Hepatitis C virus

<400>  5
uuuuucacag cg                                                           12


<210>  6
<211>  10
<212>  RNA
<213>  Hepatitis C virus

<400>  6
agcugugaaa                                                              10


<210>  7
<211>  10
<212>  RNA
<213>  Hepatitis C virus

<400>  7
cgugcccgac                                                              10


<210>  8
<211>  10
<212>  RNA
<213>  Hepatitis C virus

<400>  8
cgcgcccgac                                                              10


<210>  9
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence which specifically hybridises to the apical loop of 
       SL9266

<400>  9
ctgtgatat                                                                9


<210>  10
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence which hybridises to the apical loop of SL9266

<400>  10
tgtgatat                                                                 8


<210>  11
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence which specifically hybridises to the apical loop of 
       SL9571

<400>  11
tttcacagct                                                              10


<210>  12
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified sequence which hybridises to the apical loop of SL9571

<400>  12
tttcgcggct                                                              10


<210>  13
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified sequence which specifically hybridises to the apical 
       loop of SL9266

<400>  13
ctgtggtgt                                                                9


<210>  14
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified sequence which specifically hybridises to the apical 
       loop of SL9266

<400>  14
ctgtgggggg                                                              10


<210>  15
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence which specifically hybridises to the bulge loop of 
       SL9571

<400>  15
tcgggcac                                                                 8


<210>  16
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C_9263 - sequence targetting left hand (i.e. 5') lower and upper 
       stem of SL9266


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  locked nucleotide

<400>  16
tgtctccccc gctgtaa                                                      17


<210>  17
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JC_9587 - sequence targetting right hand (i.e. 3') stem of SL9571
       in 3' un-translated region


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  locked nucleotide

<400>  17
ggctcacgga cctt                                                         14


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C_9580/9579#1 - sequence bridging the terminal loop of SL9266 
       with the terminal loop of SL9571


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (20)..(23)
<223>  locked nucleotide

<400>  18
tttcacagct cttttgtgat ata                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C_9280/9579#2 - sequence bridging the terminal loop of SL9266 
       with the terminal loop of SL9571


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (20)..(23)
<223>  locked nucleotide

<400>  19
tttcacagct tttctgtgat ata                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C_9280/9579#3 - sequence bridging the terminal loop of SL9266 
       with the terminal loop of SL9571


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (20)..(23)
<223>  locked nucleotide

<400>  20
tttcgcggct tttctgtgat ata                                               23


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C_9280/9298 - sequence bridging the terminal loop and bulge loop 
       of SL9266


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  locked nucleotide

<400>  21
tcgggcactc taagctgtga tata                                              24


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C_9298/9579 - sequence bridging the bulge loop of SL9266 and the 
       terminal loop of SL9571


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  locked nucleotide

<400>  22
tttcacagct tcttcgggca c                                                 21


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C_9106 - sequence binging to sequences around 9110


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  locked nucleotide

<400>  23
ggacacttct ggcccgat                                                     18


<210>  24
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JC_9580 - sequence binding to SL9571 of both of Con1b and JFH-1


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  locked nucleotide

<400>  24
tcaacggacc tttcacagc                                                    19


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  J_9280/9579 - sequqnce bridging the terminal loop of SL9266 with 
       the terminal loop of SL9571


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  locked nucleotide

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  locked nucleotide

<400>  25
tttcgcggct tttttctgtg ggggg                                             25


