                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND PHARMACEUTICALS COMPOSITIONS FOR TREATING BREAST 
       CANCERS

<130>  BIO 13059 BORG / MC

<160>  2     

<170>  PatentIn version 3.3

<210>  1
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  1

Ile Glu Ser Leu Arg Val Thr Val Asp Phe Leu Lys Val Pro Leu Gly 
1               5                   10                  15      


Leu Lys Lys Pro Val Leu Lys Glu Val Ala Val Gly Pro Pro Lys Arg 
            20                  25                  30          


Pro Gln Pro Ala Ala Leu Glu Arg Tyr Lys Ala Arg Arg Ser Asp Ala 
        35                  40                  45              


Met Asp Thr Glu Ser Gln Tyr Ser Gly Tyr Ser Tyr Lys Ser Gly His 
    50                  55                  60                  


Ser Arg Ser Ser Arg Lys His Arg Asp Arg Arg Asp Arg His Arg Ser 
65                  70                  75                  80  


Lys Ser Arg Asp Gly Gly Arg Gly Asp Lys Ser Val Thr Ile Gln Ala 
                85                  90                  95      


Pro Gly Glu Pro Leu Leu Asp Asn Glu Ser Thr Arg Gly Asp Glu Arg 
            100                 105                 110         


Asp Asp Asn Trp Gly Glu Thr Thr Thr Val Val Thr Gly Thr Ser Glu 
        115                 120                 125             


His Ser Ile Ser His Asp Asp Leu Thr Arg Ile Ala Lys Asp Met Glu 
    130                 135                 140                 


Asp Ser Val Pro Leu Asp Cys Ser Arg His Leu Gly Val Ala Ala Gly 
145                 150                 155                 160 


Ala Thr Leu Ala Leu Leu Ser Phe Leu Thr Pro Leu Ala Phe Leu Leu 
                165                 170                 175     


Leu Pro Pro Leu Leu Trp Arg Glu Glu Leu Glu Pro Cys Gly Thr Ala 
            180                 185                 190         


Cys Glu Gly Leu Phe Ile Ser Val Ala Phe Lys Leu Leu Ile Leu Leu 
        195                 200                 205             


Leu Gly Ser Trp Ala Leu Phe Phe Arg Arg Pro Lys Ala Ser Leu Pro 
    210                 215                 220                 


Arg Val Phe Val Leu Arg Ala Leu Leu Met Val Leu Val Phe Leu Leu 
225                 230                 235                 240 


Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile Leu Asp Ala Arg 
                245                 250                 255     


Glu Arg Ser Tyr Gln Gly Val Val Gln Phe Ala Val Ser Leu Val Asp 
            260                 265                 270         


Ala Leu Leu Phe Val His Tyr Leu Ala Val Val Leu Leu Glu Leu Arg 
        275                 280                 285             


Gln Leu Gln Pro Gln Phe Thr Leu Lys Val Val Arg Ser Thr Asp Gly 
    290                 295                 300                 


Ala Ser Arg Phe Tyr Asn Val Gly His Leu Ser Ile Gln Arg Val Ala 
305                 310                 315                 320 


Val Trp Ile Leu Glu Lys Tyr Tyr His Asp Phe Pro Val Tyr Asn Pro 
                325                 330                 335     


Ala Leu Leu Asn Leu Pro Lys Ser Val Leu Ala Lys Lys Val Ser Gly 
            340                 345                 350         


Phe Lys Val Tyr Ser Leu Gly Glu Glu Asn Ser Thr Asn Asn Ser Thr 
        355                 360                 365             


Gly Gln Ser Arg Ala Val Ile Ala Ala Ala Ala Arg Arg Arg Asp Asn 
    370                 375                 380                 


Ser His Asn Glu Tyr Tyr Tyr Glu Glu Ala Glu His Glu Arg Arg Val 
385                 390                 395                 400 


Arg Lys Arg Arg Ala Arg Leu Val Val Ala Val Glu Glu Ala Phe Thr 
                405                 410                 415     


His Ile Lys Arg Leu Gln Glu Glu Glu Gln Lys Asn Pro Arg Glu Val 
            420                 425                 430         


Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Ala Ser Met Ala Arg 
        435                 440                 445             


Ala Met Gln Lys Tyr Leu Arg Thr Thr Lys Gln Gln Pro Tyr His Thr 
    450                 455                 460                 


Met Glu Ser Ile Leu Gln His Leu Glu Phe Cys Ile Thr His Asp Met 
465                 470                 475                 480 


Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ala Ala Gly Pro Thr Ile 
                485                 490                 495     


Gln Tyr His Lys Glu Arg Trp Leu Ala Lys Gln Trp Thr Leu Val Ser 
            500                 505                 510         


Glu Glu Pro Val Thr Asn Gly Leu Lys Asp Gly Ile Val Phe Leu Leu 
        515                 520                 525             


Lys Arg Gln Asp Phe Ser Leu Val Val Ser Thr Lys Lys Val Pro Phe 
    530                 535                 540                 


Phe Lys Leu Ser Glu Glu Phe Val Asp Pro Lys Ser His Lys Phe Val 
545                 550                 555                 560 


Met Arg Leu Gln Ser Glu Thr Ser Val 
                565                 


<210>  2
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Leu Thr Val Lys Ala Tyr Leu Leu Gly Lys Glu Asp Ala 
1               5                   10                  15      


Ala Arg Glu Ile Arg Arg Phe Ser Phe Cys Cys Ser Pro Glu Pro Glu 
            20                  25                  30          


Ala Glu Ala Glu Ala Ala Ala Gly Pro Gly Pro Cys Glu Arg Leu Leu 
        35                  40                  45              


Ser Arg Val Ala Ala Leu Phe Pro Ala Leu Arg Pro Gly Gly Phe Gln 
    50                  55                  60                  


Ala His Tyr Arg Asp Glu Asp Gly Asp Leu Val Ala Phe Ser Ser Asp 
65                  70                  75                  80  


Glu Glu Leu Thr Met Ala Met Ser Tyr Val Lys Asp Asp Ile Phe Arg 
                85                  90                  95      


Ile Tyr Ile Lys Glu Lys Lys Glu Cys Arg Arg Asp His Arg Pro Pro 
            100                 105                 110         


Cys Ala Gln Glu Ala Pro Arg Asn Met Val His Pro Asn Val Ile Cys 
        115                 120                 125             


Asp Gly Cys Asn Gly Pro Val Val Gly Thr Arg Tyr Lys Cys Ser Val 
    130                 135                 140                 


Cys Pro Asp Tyr Asp Leu Cys Ser Val Cys Glu Gly Lys Gly Leu His 
145                 150                 155                 160 


Arg Gly His Thr Lys Leu Ala Phe Pro Ser Pro Phe Gly His Leu Ser 
                165                 170                 175     


Glu Gly Phe Ser His Ser Arg Trp Leu Arg Lys Val Lys His Gly His 
            180                 185                 190         


Phe Gly Trp Pro Gly Trp Glu Met Gly Pro Pro Gly Asn Trp Ser Pro 
        195                 200                 205             


Arg Pro Pro Arg Ala Gly Glu Ala Arg Pro Gly Pro Thr Ala Glu Ser 
    210                 215                 220                 


Ala Ser Gly Pro Ser Glu Asp Pro Ser Val Asn Phe Leu Lys Asn Val 
225                 230                 235                 240 


Gly Glu Ser Val Ala Ala Ala Leu Ser Pro Leu Gly Ile Glu Val Asp 
                245                 250                 255     


Ile Asp Val Glu His Gly Gly Lys Arg Ser Arg Leu Thr Pro Val Ser 
            260                 265                 270         


Pro Glu Ser Ser Ser Thr Glu Glu Lys Ser Ser Ser Gln Pro Ser Ser 
        275                 280                 285             


Cys Cys Ser Asp Pro Ser Lys Pro Gly Gly Asn Val Glu Gly Ala Thr 
    290                 295                 300                 


Gln Ser Leu Ala Glu Gln Met Arg Lys Ile Ala Leu Glu Ser Glu Gly 
305                 310                 315                 320 


Arg Pro Glu Glu Gln Met Glu Ser Asp Asn Cys Ser Gly Gly Asp Asp 
                325                 330                 335     


Asp Trp Thr His Leu Ser Ser Lys Glu Val Asp Pro Ser Thr Gly Glu 
            340                 345                 350         


Leu Gln Ser Leu Gln Met Pro Glu Ser Glu Gly Pro Ser Ser Leu Asp 
        355                 360                 365             


Pro Ser Gln Glu Gly Pro Thr Gly Leu Lys Glu Ala Ala Leu Tyr Pro 
    370                 375                 380                 


His Leu Pro Pro Glu Ala Asp Pro Arg Leu Ile Glu Ser Leu Ser Gln 
385                 390                 395                 400 


Met Leu Ser Met Gly Phe Ser Asp Glu Gly Gly Trp Leu Thr Arg Leu 
                405                 410                 415     


Leu Gln Thr Lys Asn Tyr Asp Ile Gly Ala Ala Leu Asp Thr Ile Gln 
            420                 425                 430         


Tyr Ser Lys His Pro Pro Pro Leu 
        435                 440 


