                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
       Mao, Jeremy J
       Zheng, Ying
       Sun, Guoming
       Wang, Songlin
 
<120>  COMPOSITIONS AND METHODS FOR DENTAL TISSUE REGENERATION

<130>  88800730-0310

<150>  61/804138
<151>  2013-03-21

<150>  61/831595
<151>  2013-06-05

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Pro Leu Gly Tyr Phe Leu Leu Leu Cys Ser Leu Lys Gln Ala 
1               5                   10                  15      


Leu Gly Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr 
            20                  25                  30          


Ser Ser Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu 
        35                  40                  45              


Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro 
    50                  55                  60                  


Ser Val Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln 
65                  70                  75                  80  


Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala 
                85                  90                  95      


Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val 
            100                 105                 110         


His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys 
        115                 120                 125             


Ala Glu Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly 
    130                 135                 140                 


Ser Pro Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu 
145                 150                 155                 160 


Phe Gly Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg 
                165                 170                 175     


Pro Asp Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg 
            180                 185                 190         


Gln Ala Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu 
        195                 200                 205             


Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe 
    210                 215                 220                 


Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu 
225                 230                 235                 240 


Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu 
                245                 250                 255     


Arg Pro Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val 
            260                 265                 270         


Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly 
        275                 280                 285             


Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile 
    290                 295                 300                 


Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala 
305                 310                 315                 320 


Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr 
                325                 330                 335     


Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
            340                 345                 350         


<210>  2
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Pro Leu Gly Tyr Phe Leu Leu Leu Cys Ser Leu Lys Gln Ala 
1               5                   10                  15      


Leu Gly Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr 
            20                  25                  30          


Ser Ser Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu 
        35                  40                  45              


Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro 
    50                  55                  60                  


Ser Val Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln 
65                  70                  75                  80  


Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala 
                85                  90                  95      


Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val 
            100                 105                 110         


His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys 
        115                 120                 125             


Ala Glu Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly 
    130                 135                 140                 


Ser Pro Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu 
145                 150                 155                 160 


Phe Gly Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg 
                165                 170                 175     


Pro Asp Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg 
            180                 185                 190         


Gln Ala Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu 
        195                 200                 205             


Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe 
    210                 215                 220                 


Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu 
225                 230                 235                 240 


Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu 
                245                 250                 255     


Arg Pro Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val 
            260                 265                 270         


Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly 
        275                 280                 285             


Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile 
    290                 295                 300                 


Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala 
305                 310                 315                 320 


Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr 
                325                 330                 335     


Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
            340                 345                 350         


Asn Pro Gly Ser Arg Ala Gly Asn Ser Ala His Gln Pro Pro His Pro 
        355                 360                 365             


Gln Pro Pro Val Arg Phe His Pro Pro Leu Arg Arg Ala Gly Lys Val 
    370                 375                 380                 


Pro 
385 


<210>  3
<211>  328
<212>  PRT
<213>  Mus musculus

<400>  3

Ser Leu Ala Val Gly Pro Gln Tyr Ser Ser Leu Ser Thr Gln Pro Ile 
1               5                   10                  15      


Leu Cys Ala Ser Ile Pro Gly Leu Val Pro Lys Gln Leu Arg Phe Cys 
            20                  25                  30          


Arg Asn Tyr Val Glu Ile Met Pro Ser Val Ala Glu Gly Val Lys Ala 
        35                  40                  45              


Gly Ile Gln Glu Cys Gln His Gln Phe Arg Gly Arg Arg Trp Asn Cys 
    50                  55                  60                  


Thr Thr Val Ser Asn Ser Leu Ala Ile Phe Gly Pro Val Leu Asp Lys 
65                  70                  75                  80  


Ala Thr Arg Glu Ser Ala Phe Val His Ala Ile Ala Ser Ala Gly Val 
                85                  90                  95      


Ala Phe Ala Val Thr Arg Ser Cys Ala Glu Gly Ser Ala Ala Ile Cys 
            100                 105                 110         


Gly Cys Ser Ser Arg Leu Gln Gly Ser Pro Gly Glu Gly Trp Lys Trp 
        115                 120                 125             


Gly Gly Cys Ser Glu Asp Ile Glu Phe Gly Gly Met Val Ser Arg Glu 
    130                 135                 140                 


Phe Ala Asp Ala Arg Glu Asn Arg Pro Asp Ala Arg Ser Ala Met Asn 
145                 150                 155                 160 


Arg His Asn Asn Glu Ala Gly Arg Gln Ala Ile Ala Ser His Met His 
                165                 170                 175     


Leu Lys Cys Lys Cys His Gly Leu Ser Gly Ser Cys Glu Val Lys Thr 
            180                 185                 190         


Cys Trp Trp Ser Gln Pro Asp Phe Arg Thr Ile Gly Asp Phe Leu Lys 
        195                 200                 205             


Asp Lys Tyr Asp Ser Ala Ser Glu Met Val Val Glu Lys His Arg Glu 
    210                 215                 220                 


Ser Arg Gly Trp Val Glu Thr Leu Arg Pro Arg Tyr Thr Tyr Phe Lys 
225                 230                 235                 240 


Val Pro Thr Glu Arg Asp Leu Val Tyr Tyr Glu Ala Ser Pro Asn Phe 
                245                 250                 255     


Cys Glu Pro Asn Pro Glu Thr Gly Ser Phe Gly Thr Arg Asp Arg Thr 
            260                 265                 270         


Cys Asn Val Ser Ser His Gly Ile Asp Gly Cys Asp Leu Leu Cys Cys 
        275                 280                 285             


Gly Arg Gly His Asn Ala Arg Thr Glu Arg Arg Arg Glu Lys Cys His 
    290                 295                 300                 


Cys Val Phe His Trp Cys Cys Tyr Val Ser Cys Gln Glu Cys Thr Arg 
305                 310                 315                 320 


Val Tyr Asp Val His Thr Cys Lys 
                325             


<210>  4
<211>  417
<212>  PRT
<213>  Hydra vulgaris

<400>  4

Met Gln Tyr Lys Leu Ala Leu Asn Gly Lys Thr Leu Lys Gly Glu Thr 
1               5                   10                  15      


Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys Gln 
            20                  25                  30          


Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp Ala 
        35                  40                  45              


Thr Lys Thr Phe Thr Val Thr Glu Leu Val Pro Arg Gly Ser Gln Leu 
    50                  55                  60                  


Trp Met Ala Leu Gly Thr Gln Thr Ser Ala Ile Glu Ser Arg Pro Arg 
65                  70                  75                  80  


Ser Ser Ile Asn Lys Asn Leu Cys Arg Ala Leu Tyr Leu His His Tyr 
                85                  90                  95      


Gln Arg Thr Val Cys Leu Asn Tyr Thr Asp Leu Met Leu Ser Val Ala 
            100                 105                 110         


Glu Gly Ile Arg Leu Gly Ile Asp Glu Cys Gln Val Gln Phe Lys His 
        115                 120                 125             


Arg Lys Trp Asn Cys Thr Ile Asn Glu His Gly Thr Ser Val Phe Gly 
    130                 135                 140                 


Pro Ile Ile Thr Thr Ala Ser Arg Glu Ser Ala Phe Ile Ser Gly Ile 
145                 150                 155                 160 


Ile Ser Ala Gly Val Ala Phe Ser Val Thr Glu Ser Cys Ala Glu Gly 
                165                 170                 175     


Lys Ser Val His Cys Arg Cys Asp Asn Ser Val Arg Gly Gln Thr Asp 
            180                 185                 190         


Glu Gly Trp Arg Trp Gly Gly Cys Asn Arg Pro Ile Thr Tyr Gly Ile 
        195                 200                 205             


Trp Phe Ser Gln Leu Phe Ile Asp Gln Val Glu Lys Ile Val Lys Lys 
    210                 215                 220                 


Arg Lys Asp Pro Arg Lys Ile Met Asn Leu His Asn Asn Lys Ala Gly 
225                 230                 235                 240 


Arg Glu Val Ile Lys Asn Leu Leu Gln Thr Glu Cys Lys Cys His Gly 
                245                 250                 255     


Thr Ser Gly Asn Cys Asn Leu Lys Thr Cys Trp Arg Ser Gln Pro His 
            260                 265                 270         


Phe Ser Glu Ile Gly Lys Ile Leu Lys Glu Lys Tyr Asp Ser Ala His 
        275                 280                 285             


Glu Met Glu Phe Leu Tyr Lys Val Lys Ala Asn Gly Glu Arg Lys Ile 
    290                 295                 300                 


Lys Asp Leu Ile Pro Lys Tyr Lys Glu Tyr Leu Pro Pro Ser Ser Leu 
305                 310                 315                 320 


Asp Phe Ile Tyr Tyr Glu Glu Ser Pro Asn Tyr Cys Val Lys Asn Glu 
                325                 330                 335     


Thr Leu Gly Ile Ala Gly Thr Lys Gly Arg Ser Cys Asn Ile Thr Ser 
            340                 345                 350         


Ser Gly Val Asp Gly Cys Glu Leu Met Cys Cys Gln Arg Gly Tyr Asn 
        355                 360                 365             


Val Asn Ile Val Gln Lys Thr His Ser Cys Glu Cys Lys Phe Val Trp 
    370                 375                 380                 


Cys Cys Lys Val Ser Cys Asn Ser Cys Ile Lys Met Thr Pro Glu Tyr 
385                 390                 395                 400 


Thr Cys Lys Leu Val Pro Arg Gly Ser Leu Glu His His His His His 
                405                 410                 415     


His 
    


