                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Liao, James C.
       Bogorad, Igor
 
<120>  RECOMBINANT MICROORGANISMS HAVING A METHANOL ELONGATION CYCLE 
       (MEC)

<130>  00011-072WO1

<140>  Not yet assigned
<141>  2014-03-14

<150>  US 61/785,143
<151>  2013-03-14

<150>  US 61/785,254
<151>  2013-03-14

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  2478
<212>  DNA
<213>  Bifidobacterium adolescentis


<220>
<221>  CDS
<222>  (1)..(2478)

<400>  1
atg acg agt cct gtt att ggc acc cct tgg aag aag ctg aac gct ccg         48
Met Thr Ser Pro Val Ile Gly Thr Pro Trp Lys Lys Leu Asn Ala Pro           
1               5                   10                  15                

gtt tcc gag gaa gct atc gaa ggc gtg gat aag tac tgg cgc gca gcc         96
Val Ser Glu Glu Ala Ile Glu Gly Val Asp Lys Tyr Trp Arg Ala Ala           
            20                  25                  30                    

aac tac ctc tcc atc ggc cag atc tat ctg cgt agc aac ccg ctg atg        144
Asn Tyr Leu Ser Ile Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu Met           
        35                  40                  45                        

aag gag cct ttc acc cgc gaa gac gtc aag cac cgt ctg gtc ggt cac        192
Lys Glu Pro Phe Thr Arg Glu Asp Val Lys His Arg Leu Val Gly His           
    50                  55                  60                            

tgg ggc acc acc ccg ggc ctg aac ttc ctc atc ggc cac atc aac cgt        240
Trp Gly Thr Thr Pro Gly Leu Asn Phe Leu Ile Gly His Ile Asn Arg           
65                  70                  75                  80            

ctc att gct gat cac cag cag aac act gtg atc atc atg ggc ccg ggc        288
Leu Ile Ala Asp His Gln Gln Asn Thr Val Ile Ile Met Gly Pro Gly           
                85                  90                  95                

cac ggc ggc ccg gct ggt acc gct cag tcc tac ctg gac ggc acc tac        336
His Gly Gly Pro Ala Gly Thr Ala Gln Ser Tyr Leu Asp Gly Thr Tyr           
            100                 105                 110                   

acc gag tac ttc ccg aac atc acc aag gat gag gct ggc ctg cag aag        384
Thr Glu Tyr Phe Pro Asn Ile Thr Lys Asp Glu Ala Gly Leu Gln Lys           
        115                 120                 125                       

ttc ttc cgc cag ttc tcc tac ccg ggt ggc atc ccg tcc cac tac gct        432
Phe Phe Arg Gln Phe Ser Tyr Pro Gly Gly Ile Pro Ser His Tyr Ala           
    130                 135                 140                           

ccg gag acc ccg ggc tcc atc cac gaa ggc ggc gag ctg ggt tac gcc        480
Pro Glu Thr Pro Gly Ser Ile His Glu Gly Gly Glu Leu Gly Tyr Ala           
145                 150                 155                 160           

ctg tcc cac gcc tac ggc gct gtg atg aac aac ccg agc ctg ttc gtc        528
Leu Ser His Ala Tyr Gly Ala Val Met Asn Asn Pro Ser Leu Phe Val           
                165                 170                 175               

ccg gcc atc gtc ggc gac ggt gaa gct gag acc ggc ccg ctg gcc acc        576
Pro Ala Ile Val Gly Asp Gly Glu Ala Glu Thr Gly Pro Leu Ala Thr           
            180                 185                 190                   

ggc tgg cag tcc aac aag ctc atc aac ccg cgc acc gac ggt atc gtg        624
Gly Trp Gln Ser Asn Lys Leu Ile Asn Pro Arg Thr Asp Gly Ile Val           
        195                 200                 205                       

ctg ccg atc ctg cac ctc aac ggc tac aag atc gcc aac ccg acc atc        672
Leu Pro Ile Leu His Leu Asn Gly Tyr Lys Ile Ala Asn Pro Thr Ile           
    210                 215                 220                           

ctg tcc cgc atc tcc gac gaa gag ctc cac gag ttc ttc cac ggc atg        720
Leu Ser Arg Ile Ser Asp Glu Glu Leu His Glu Phe Phe His Gly Met           
225                 230                 235                 240           

ggc tat gag ccg tac gag ttc gtc gct ggc ttc gac aac gag gat cac        768
Gly Tyr Glu Pro Tyr Glu Phe Val Ala Gly Phe Asp Asn Glu Asp His           
                245                 250                 255               

ctg tcg atc cac cgt cgt ttc gcc gag ctg ttc gag acc gtc ttc gac        816
Leu Ser Ile His Arg Arg Phe Ala Glu Leu Phe Glu Thr Val Phe Asp           
            260                 265                 270                   

gag atc tgc gac atc aag gcc gcc gct cag acc gac gac atg act cgt        864
Glu Ile Cys Asp Ile Lys Ala Ala Ala Gln Thr Asp Asp Met Thr Arg           
        275                 280                 285                       

ccg ttc tac ccg atg atc atc ttc cgt acc ccg aag ggc tgg acc tgc        912
Pro Phe Tyr Pro Met Ile Ile Phe Arg Thr Pro Lys Gly Trp Thr Cys           
    290                 295                 300                           

ccg aag ttc atc gac ggc aag aag acc gag ggc tcc tgg cgt tcc cac        960
Pro Lys Phe Ile Asp Gly Lys Lys Thr Glu Gly Ser Trp Arg Ser His           
305                 310                 315                 320           

cag gtg ccg ctg gct tcc gcc cgc gat acc gag gcc cac ttc gag gtc       1008
Gln Val Pro Leu Ala Ser Ala Arg Asp Thr Glu Ala His Phe Glu Val           
                325                 330                 335               

ctc aag aac tgg ctc gag tcc tac aag ccg gaa gag ctg ttc gac gag       1056
Leu Lys Asn Trp Leu Glu Ser Tyr Lys Pro Glu Glu Leu Phe Asp Glu           
            340                 345                 350                   

aac ggc gcc gtg aag ccg gaa gtc acc gcc ttc atg ccg acc ggc gaa       1104
Asn Gly Ala Val Lys Pro Glu Val Thr Ala Phe Met Pro Thr Gly Glu           
        355                 360                 365                       

ctg cgc atc ggt gag aac ccg aac gcc aac ggt ggc cgc atc cgc gaa       1152
Leu Arg Ile Gly Glu Asn Pro Asn Ala Asn Gly Gly Arg Ile Arg Glu           
    370                 375                 380                           

gag ctg aag ctg ccg aag ctg gaa gac tac gag gtc aag gaa gtc gcc       1200
Glu Leu Lys Leu Pro Lys Leu Glu Asp Tyr Glu Val Lys Glu Val Ala           
385                 390                 395                 400           

gag tac ggc cac ggc tgg ggc cag ctc gag gcc acc cgt cgt ctg ggc       1248
Glu Tyr Gly His Gly Trp Gly Gln Leu Glu Ala Thr Arg Arg Leu Gly           
                405                 410                 415               

gtc tac acc cgc gac atc atc aag aac aac ccg gac tcc ttc cgt atc       1296
Val Tyr Thr Arg Asp Ile Ile Lys Asn Asn Pro Asp Ser Phe Arg Ile           
            420                 425                 430                   

ttc gga ccg gat gag acc gct tcc aac cgt ctg cag gcc gct tac gac       1344
Phe Gly Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr Asp           
        435                 440                 445                       

gtc acc aac aag cag tgg gac gcc ggc tac ctg tcc gct cag gtc gac       1392
Val Thr Asn Lys Gln Trp Asp Ala Gly Tyr Leu Ser Ala Gln Val Asp           
    450                 455                 460                           

gag cac atg gct gtc acc ggc cag gtc acc gag cag ctt tcc gag cac       1440
Glu His Met Ala Val Thr Gly Gln Val Thr Glu Gln Leu Ser Glu His           
465                 470                 475                 480           

cag atg gaa ggc ttc ctc gag ggc tac ctg ctg acc ggc cgt cac ggc       1488
Gln Met Glu Gly Phe Leu Glu Gly Tyr Leu Leu Thr Gly Arg His Gly           
                485                 490                 495               

atc tgg agc tcc tat gag tcc ttc gtg cac gtg atc gac tcc atg ctg       1536
Ile Trp Ser Ser Tyr Glu Ser Phe Val His Val Ile Asp Ser Met Leu           
            500                 505                 510                   

aac cag cac gcc aag tgg ctc gag gct acc gtc cgc gag att ccg tgg       1584
Asn Gln His Ala Lys Trp Leu Glu Ala Thr Val Arg Glu Ile Pro Trp           
        515                 520                 525                       

cgc aag ccg atc tcc tcc atg aac ctg ctc gtc tcc tcc cac gtg tgg       1632
Arg Lys Pro Ile Ser Ser Met Asn Leu Leu Val Ser Ser His Val Trp           
    530                 535                 540                           

cgt cag gat cac aac ggc ttc tcc cac cag gat ccg ggt gtc acc tcc       1680
Arg Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Val Thr Ser           
545                 550                 555                 560           

gtc ctg ctg aac aag tgc ttc aac aac gat cac gtg atc ggc atc tac       1728
Val Leu Leu Asn Lys Cys Phe Asn Asn Asp His Val Ile Gly Ile Tyr           
                565                 570                 575               

ttc ccg gtg gat tcc aac atg ctg ctc gct gtg gct gag aag tgc tac       1776
Phe Pro Val Asp Ser Asn Met Leu Leu Ala Val Ala Glu Lys Cys Tyr           
            580                 585                 590                   

aag tcc acc aac aag atc aac gcc atc atc gcc ggc aag cag ccg gcc       1824
Lys Ser Thr Asn Lys Ile Asn Ala Ile Ile Ala Gly Lys Gln Pro Ala           
        595                 600                 605                       

gcc acc tgg ctg acc ctg gac gaa gct cgc gcc gag ctc gag aag ggt       1872
Ala Thr Trp Leu Thr Leu Asp Glu Ala Arg Ala Glu Leu Glu Lys Gly           
    610                 615                 620                           

gct gcc gag tgg aag tgg gct tcc aac gtg aag tcc aac gat gag gct       1920
Ala Ala Glu Trp Lys Trp Ala Ser Asn Val Lys Ser Asn Asp Glu Ala           
625                 630                 635                 640           

cag atc gtg ctc gcc gcc acc ggt gat gtt ccg act cag gaa atc atg       1968
Gln Ile Val Leu Ala Ala Thr Gly Asp Val Pro Thr Gln Glu Ile Met           
                645                 650                 655               

gcc gct gcc gac aag ctg gac gcc atg ggc atc aag ttc aag gtc gtc       2016
Ala Ala Ala Asp Lys Leu Asp Ala Met Gly Ile Lys Phe Lys Val Val           
            660                 665                 670                   

aac gtg gtt gac ctg gtc aag ctg cag tcc gcc aag gag aac aac gag       2064
Asn Val Val Asp Leu Val Lys Leu Gln Ser Ala Lys Glu Asn Asn Glu           
        675                 680                 685                       

gcc ctc tcc gat gag gag ttc gct gag ctg ttc acc gag gac aag ccg       2112
Ala Leu Ser Asp Glu Glu Phe Ala Glu Leu Phe Thr Glu Asp Lys Pro           
    690                 695                 700                           

gtc ctg ttc gct tac cac tcc tat gcc cgc gat gtg cgt ggt ctg atc       2160
Val Leu Phe Ala Tyr His Ser Tyr Ala Arg Asp Val Arg Gly Leu Ile           
705                 710                 715                 720           

tac gat cgc ccg aac cac gac aac ttc aac gtt cac ggc tac gag gag       2208
Tyr Asp Arg Pro Asn His Asp Asn Phe Asn Val His Gly Tyr Glu Glu           
                725                 730                 735               

cag ggc tcc acc acc acc ccg tac gac atg gtt cgc gtg aac aac atc       2256
Gln Gly Ser Thr Thr Thr Pro Tyr Asp Met Val Arg Val Asn Asn Ile           
            740                 745                 750                   

gat cgc tac gag ctc cag gct gaa gct ctg cgc atg att gac gct gac       2304
Asp Arg Tyr Glu Leu Gln Ala Glu Ala Leu Arg Met Ile Asp Ala Asp           
        755                 760                 765                       

aag tac gcc gac aag atc aac gag ctc gag gcc ttc cgt cag gaa gcc       2352
Lys Tyr Ala Asp Lys Ile Asn Glu Leu Glu Ala Phe Arg Gln Glu Ala           
    770                 775                 780                           

ttc cag ttc gct gtc gac aac ggc tac gat cac ccg gat tac acc gac       2400
Phe Gln Phe Ala Val Asp Asn Gly Tyr Asp His Pro Asp Tyr Thr Asp           
785                 790                 795                 800           

tgg gtc tac tcc ggt gtc aac acc aac aag cag ggt gct atc tcc gct       2448
Trp Val Tyr Ser Gly Val Asn Thr Asn Lys Gln Gly Ala Ile Ser Ala           
                805                 810                 815               

acc gcc gca acc gct ggc gat aac gag tga                               2478
Thr Ala Ala Thr Ala Gly Asp Asn Glu                                       
            820                 825                                       


<210>  2
<211>  825
<212>  PRT
<213>  Bifidobacterium adolescentis

<400>  2

Met Thr Ser Pro Val Ile Gly Thr Pro Trp Lys Lys Leu Asn Ala Pro 
1               5                   10                  15      


Val Ser Glu Glu Ala Ile Glu Gly Val Asp Lys Tyr Trp Arg Ala Ala 
            20                  25                  30          


Asn Tyr Leu Ser Ile Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu Met 
        35                  40                  45              


Lys Glu Pro Phe Thr Arg Glu Asp Val Lys His Arg Leu Val Gly His 
    50                  55                  60                  


Trp Gly Thr Thr Pro Gly Leu Asn Phe Leu Ile Gly His Ile Asn Arg 
65                  70                  75                  80  


Leu Ile Ala Asp His Gln Gln Asn Thr Val Ile Ile Met Gly Pro Gly 
                85                  90                  95      


His Gly Gly Pro Ala Gly Thr Ala Gln Ser Tyr Leu Asp Gly Thr Tyr 
            100                 105                 110         


Thr Glu Tyr Phe Pro Asn Ile Thr Lys Asp Glu Ala Gly Leu Gln Lys 
        115                 120                 125             


Phe Phe Arg Gln Phe Ser Tyr Pro Gly Gly Ile Pro Ser His Tyr Ala 
    130                 135                 140                 


Pro Glu Thr Pro Gly Ser Ile His Glu Gly Gly Glu Leu Gly Tyr Ala 
145                 150                 155                 160 


Leu Ser His Ala Tyr Gly Ala Val Met Asn Asn Pro Ser Leu Phe Val 
                165                 170                 175     


Pro Ala Ile Val Gly Asp Gly Glu Ala Glu Thr Gly Pro Leu Ala Thr 
            180                 185                 190         


Gly Trp Gln Ser Asn Lys Leu Ile Asn Pro Arg Thr Asp Gly Ile Val 
        195                 200                 205             


Leu Pro Ile Leu His Leu Asn Gly Tyr Lys Ile Ala Asn Pro Thr Ile 
    210                 215                 220                 


Leu Ser Arg Ile Ser Asp Glu Glu Leu His Glu Phe Phe His Gly Met 
225                 230                 235                 240 


Gly Tyr Glu Pro Tyr Glu Phe Val Ala Gly Phe Asp Asn Glu Asp His 
                245                 250                 255     


Leu Ser Ile His Arg Arg Phe Ala Glu Leu Phe Glu Thr Val Phe Asp 
            260                 265                 270         


Glu Ile Cys Asp Ile Lys Ala Ala Ala Gln Thr Asp Asp Met Thr Arg 
        275                 280                 285             


Pro Phe Tyr Pro Met Ile Ile Phe Arg Thr Pro Lys Gly Trp Thr Cys 
    290                 295                 300                 


Pro Lys Phe Ile Asp Gly Lys Lys Thr Glu Gly Ser Trp Arg Ser His 
305                 310                 315                 320 


Gln Val Pro Leu Ala Ser Ala Arg Asp Thr Glu Ala His Phe Glu Val 
                325                 330                 335     


Leu Lys Asn Trp Leu Glu Ser Tyr Lys Pro Glu Glu Leu Phe Asp Glu 
            340                 345                 350         


Asn Gly Ala Val Lys Pro Glu Val Thr Ala Phe Met Pro Thr Gly Glu 
        355                 360                 365             


Leu Arg Ile Gly Glu Asn Pro Asn Ala Asn Gly Gly Arg Ile Arg Glu 
    370                 375                 380                 


Glu Leu Lys Leu Pro Lys Leu Glu Asp Tyr Glu Val Lys Glu Val Ala 
385                 390                 395                 400 


Glu Tyr Gly His Gly Trp Gly Gln Leu Glu Ala Thr Arg Arg Leu Gly 
                405                 410                 415     


Val Tyr Thr Arg Asp Ile Ile Lys Asn Asn Pro Asp Ser Phe Arg Ile 
            420                 425                 430         


Phe Gly Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr Asp 
        435                 440                 445             


Val Thr Asn Lys Gln Trp Asp Ala Gly Tyr Leu Ser Ala Gln Val Asp 
    450                 455                 460                 


Glu His Met Ala Val Thr Gly Gln Val Thr Glu Gln Leu Ser Glu His 
465                 470                 475                 480 


Gln Met Glu Gly Phe Leu Glu Gly Tyr Leu Leu Thr Gly Arg His Gly 
                485                 490                 495     


Ile Trp Ser Ser Tyr Glu Ser Phe Val His Val Ile Asp Ser Met Leu 
            500                 505                 510         


Asn Gln His Ala Lys Trp Leu Glu Ala Thr Val Arg Glu Ile Pro Trp 
        515                 520                 525             


Arg Lys Pro Ile Ser Ser Met Asn Leu Leu Val Ser Ser His Val Trp 
    530                 535                 540                 


Arg Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Val Thr Ser 
545                 550                 555                 560 


Val Leu Leu Asn Lys Cys Phe Asn Asn Asp His Val Ile Gly Ile Tyr 
                565                 570                 575     


Phe Pro Val Asp Ser Asn Met Leu Leu Ala Val Ala Glu Lys Cys Tyr 
            580                 585                 590         


Lys Ser Thr Asn Lys Ile Asn Ala Ile Ile Ala Gly Lys Gln Pro Ala 
        595                 600                 605             


Ala Thr Trp Leu Thr Leu Asp Glu Ala Arg Ala Glu Leu Glu Lys Gly 
    610                 615                 620                 


Ala Ala Glu Trp Lys Trp Ala Ser Asn Val Lys Ser Asn Asp Glu Ala 
625                 630                 635                 640 


Gln Ile Val Leu Ala Ala Thr Gly Asp Val Pro Thr Gln Glu Ile Met 
                645                 650                 655     


Ala Ala Ala Asp Lys Leu Asp Ala Met Gly Ile Lys Phe Lys Val Val 
            660                 665                 670         


Asn Val Val Asp Leu Val Lys Leu Gln Ser Ala Lys Glu Asn Asn Glu 
        675                 680                 685             


Ala Leu Ser Asp Glu Glu Phe Ala Glu Leu Phe Thr Glu Asp Lys Pro 
    690                 695                 700                 


Val Leu Phe Ala Tyr His Ser Tyr Ala Arg Asp Val Arg Gly Leu Ile 
705                 710                 715                 720 


Tyr Asp Arg Pro Asn His Asp Asn Phe Asn Val His Gly Tyr Glu Glu 
                725                 730                 735     


Gln Gly Ser Thr Thr Thr Pro Tyr Asp Met Val Arg Val Asn Asn Ile 
            740                 745                 750         


Asp Arg Tyr Glu Leu Gln Ala Glu Ala Leu Arg Met Ile Asp Ala Asp 
        755                 760                 765             


Lys Tyr Ala Asp Lys Ile Asn Glu Leu Glu Ala Phe Arg Gln Glu Ala 
    770                 775                 780                 


Phe Gln Phe Ala Val Asp Asn Gly Tyr Asp His Pro Asp Tyr Thr Asp 
785                 790                 795                 800 


Trp Val Tyr Ser Gly Val Asn Thr Asn Lys Gln Gly Ala Ile Ser Ala 
                805                 810                 815     


Thr Ala Ala Thr Ala Gly Asp Asn Glu 
            820                 825 


<210>  3
<211>  1152
<212>  DNA
<213>  Bacillus methanolicus


<220>
<221>  CDS
<222>  (1)..(1152)

<400>  3
atg acg caa aga aac ttt ttc att cca cca gct agc gta att gga cgc         48
Met Thr Gln Arg Asn Phe Phe Ile Pro Pro Ala Ser Val Ile Gly Arg           
1               5                   10                  15                

ggc gct gta aaa gaa gta gga aca aga ctt aag caa att gga gct aca         96
Gly Ala Val Lys Glu Val Gly Thr Arg Leu Lys Gln Ile Gly Ala Thr           
            20                  25                  30                    

aaa gca ctt atc gtt aca gat gca ttt ctt cat ggc aca ggt ttg tca        144
Lys Ala Leu Ile Val Thr Asp Ala Phe Leu His Gly Thr Gly Leu Ser           
        35                  40                  45                        

gaa gaa gtt gct aaa aac att cgt gaa gct ggc ctt gat gct gta att        192
Glu Glu Val Ala Lys Asn Ile Arg Glu Ala Gly Leu Asp Ala Val Ile           
    50                  55                  60                            

ttc cca aaa gct caa cca gat cca gca gat aca caa gtt cat gaa ggc        240
Phe Pro Lys Ala Gln Pro Asp Pro Ala Asp Thr Gln Val His Glu Gly           
65                  70                  75                  80            

gta gat ata ttc aaa caa gaa aaa tgt gat gca ctt gtt tct atc ggt        288
Val Asp Ile Phe Lys Gln Glu Lys Cys Asp Ala Leu Val Ser Ile Gly           
                85                  90                  95                

gga ggt agc tct cac gat aca gca aaa gca atc ggt tta gtt gca gca        336
Gly Gly Ser Ser His Asp Thr Ala Lys Ala Ile Gly Leu Val Ala Ala           
            100                 105                 110                   

aac ggc gga aga atc aac gac tat caa ggt gta aac agt gta gaa aaa        384
Asn Gly Gly Arg Ile Asn Asp Tyr Gln Gly Val Asn Ser Val Glu Lys           
        115                 120                 125                       

ccg gtt gtt cca gta gtt gca atc act aca aca gct ggt act ggt agt        432
Pro Val Val Pro Val Val Ala Ile Thr Thr Thr Ala Gly Thr Gly Ser           
    130                 135                 140                           

gaa aca aca tct ctt gcg gtt att aca gat tct gca cgt aaa gta aaa        480
Glu Thr Thr Ser Leu Ala Val Ile Thr Asp Ser Ala Arg Lys Val Lys           
145                 150                 155                 160           

atg cca gtt atc gat gag aaa att aca cca act gta gca att gtt gac        528
Met Pro Val Ile Asp Glu Lys Ile Thr Pro Thr Val Ala Ile Val Asp           
                165                 170                 175               

cca gaa tta atg gtg aaa aaa cca gct gga tta aca att gca act ggt        576
Pro Glu Leu Met Val Lys Lys Pro Ala Gly Leu Thr Ile Ala Thr Gly           
            180                 185                 190                   

atg gat gca tta tcc cat gca att gaa gca tat gtt gca aaa cgt gct        624
Met Asp Ala Leu Ser His Ala Ile Glu Ala Tyr Val Ala Lys Arg Ala           
        195                 200                 205                       

aca cca gtt act gat gcg ttt gca att caa gca atg aaa ctc att aat        672
Thr Pro Val Thr Asp Ala Phe Ala Ile Gln Ala Met Lys Leu Ile Asn           
    210                 215                 220                           

gaa tac tta cca cgt gcg gtt gca aat gga gaa gac atc gaa gca cgt        720
Glu Tyr Leu Pro Arg Ala Val Ala Asn Gly Glu Asp Ile Glu Ala Arg           
225                 230                 235                 240           

gaa gca atg gct tat gca caa tac atg gca gga gtg gca ttt aac aac        768
Glu Ala Met Ala Tyr Ala Gln Tyr Met Ala Gly Val Ala Phe Asn Asn           
                245                 250                 255               

gga ggt tta gga tta gta cac tct att tct cac caa gta ggt gga gtt        816
Gly Gly Leu Gly Leu Val His Ser Ile Ser His Gln Val Gly Gly Val           
            260                 265                 270                   

tac aag tta caa cac gga atc tgt aac tca gtt aat atg cca cac gtt        864
Tyr Lys Leu Gln His Gly Ile Cys Asn Ser Val Asn Met Pro His Val           
        275                 280                 285                       

tgc caa ttc aac tta att gct cgt act gaa cgc ttc gca cac att gct        912
Cys Gln Phe Asn Leu Ile Ala Arg Thr Glu Arg Phe Ala His Ile Ala           
    290                 295                 300                           

gag ctt tta ggc gag aat gtt tct ggc tta agc act gca tct gct gct        960
Glu Leu Leu Gly Glu Asn Val Ser Gly Leu Ser Thr Ala Ser Ala Ala           
305                 310                 315                 320           

gag aga gca att gta gcg ctt caa cgc tat aac aaa aac ttc ggt atc       1008
Glu Arg Ala Ile Val Ala Leu Gln Arg Tyr Asn Lys Asn Phe Gly Ile           
                325                 330                 335               

cca tct ggc tat gca gaa atg ggc gta aaa gaa gag gat atc gaa tta       1056
Pro Ser Gly Tyr Ala Glu Met Gly Val Lys Glu Glu Asp Ile Glu Leu           
            340                 345                 350                   

tta gcg aac aac gcg tac caa gac gta tgt act cta gat aac cca cgt       1104
Leu Ala Asn Asn Ala Tyr Gln Asp Val Cys Thr Leu Asp Asn Pro Arg           
        355                 360                 365                       

gtt cct act gtt caa gac att gca caa atc atc aaa aac gct ctg taa       1152
Val Pro Thr Val Gln Asp Ile Ala Gln Ile Ile Lys Asn Ala Leu               
    370                 375                 380                           


<210>  4
<211>  383
<212>  PRT
<213>  Bacillus methanolicus

<400>  4

Met Thr Gln Arg Asn Phe Phe Ile Pro Pro Ala Ser Val Ile Gly Arg 
1               5                   10                  15      


Gly Ala Val Lys Glu Val Gly Thr Arg Leu Lys Gln Ile Gly Ala Thr 
            20                  25                  30          


Lys Ala Leu Ile Val Thr Asp Ala Phe Leu His Gly Thr Gly Leu Ser 
        35                  40                  45              


Glu Glu Val Ala Lys Asn Ile Arg Glu Ala Gly Leu Asp Ala Val Ile 
    50                  55                  60                  


Phe Pro Lys Ala Gln Pro Asp Pro Ala Asp Thr Gln Val His Glu Gly 
65                  70                  75                  80  


Val Asp Ile Phe Lys Gln Glu Lys Cys Asp Ala Leu Val Ser Ile Gly 
                85                  90                  95      


Gly Gly Ser Ser His Asp Thr Ala Lys Ala Ile Gly Leu Val Ala Ala 
            100                 105                 110         


Asn Gly Gly Arg Ile Asn Asp Tyr Gln Gly Val Asn Ser Val Glu Lys 
        115                 120                 125             


Pro Val Val Pro Val Val Ala Ile Thr Thr Thr Ala Gly Thr Gly Ser 
    130                 135                 140                 


Glu Thr Thr Ser Leu Ala Val Ile Thr Asp Ser Ala Arg Lys Val Lys 
145                 150                 155                 160 


Met Pro Val Ile Asp Glu Lys Ile Thr Pro Thr Val Ala Ile Val Asp 
                165                 170                 175     


Pro Glu Leu Met Val Lys Lys Pro Ala Gly Leu Thr Ile Ala Thr Gly 
            180                 185                 190         


Met Asp Ala Leu Ser His Ala Ile Glu Ala Tyr Val Ala Lys Arg Ala 
        195                 200                 205             


Thr Pro Val Thr Asp Ala Phe Ala Ile Gln Ala Met Lys Leu Ile Asn 
    210                 215                 220                 


Glu Tyr Leu Pro Arg Ala Val Ala Asn Gly Glu Asp Ile Glu Ala Arg 
225                 230                 235                 240 


Glu Ala Met Ala Tyr Ala Gln Tyr Met Ala Gly Val Ala Phe Asn Asn 
                245                 250                 255     


Gly Gly Leu Gly Leu Val His Ser Ile Ser His Gln Val Gly Gly Val 
            260                 265                 270         


Tyr Lys Leu Gln His Gly Ile Cys Asn Ser Val Asn Met Pro His Val 
        275                 280                 285             


Cys Gln Phe Asn Leu Ile Ala Arg Thr Glu Arg Phe Ala His Ile Ala 
    290                 295                 300                 


Glu Leu Leu Gly Glu Asn Val Ser Gly Leu Ser Thr Ala Ser Ala Ala 
305                 310                 315                 320 


Glu Arg Ala Ile Val Ala Leu Gln Arg Tyr Asn Lys Asn Phe Gly Ile 
                325                 330                 335     


Pro Ser Gly Tyr Ala Glu Met Gly Val Lys Glu Glu Asp Ile Glu Leu 
            340                 345                 350         


Leu Ala Asn Asn Ala Tyr Gln Asp Val Cys Thr Leu Asp Asn Pro Arg 
        355                 360                 365             


Val Pro Thr Val Gln Asp Ile Ala Gln Ile Ile Lys Asn Ala Leu 
    370                 375                 380             


<210>  5
<211>  678
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(678)

<400>  5
atg aaa cag tat ttg att gcc ccc tca att ctg tcg gct gat ttt gcc         48
Met Lys Gln Tyr Leu Ile Ala Pro Ser Ile Leu Ser Ala Asp Phe Ala           
1               5                   10                  15                

cgc ctg ggt gaa gat acc gca aaa gcc ctg gca gct ggc gct gat gtc         96
Arg Leu Gly Glu Asp Thr Ala Lys Ala Leu Ala Ala Gly Ala Asp Val           
            20                  25                  30                    

gtg cat ttt gac gtc atg gat aac cac tat gtt ccc aat ctg acg att        144
Val His Phe Asp Val Met Asp Asn His Tyr Val Pro Asn Leu Thr Ile           
        35                  40                  45                        

ggg cca atg gtg ctg aaa tcc ttg cgt aac tat ggc att acc gcc cct        192
Gly Pro Met Val Leu Lys Ser Leu Arg Asn Tyr Gly Ile Thr Ala Pro           
    50                  55                  60                            

atc gac gta cac ctg atg gtg aaa ccc gtc gat cgc att gtg cct gat        240
Ile Asp Val His Leu Met Val Lys Pro Val Asp Arg Ile Val Pro Asp           
65                  70                  75                  80            

ttc gct gcc gct ggt gcc agc atc att acc ttt cat cca gaa gcc tcc        288
Phe Ala Ala Ala Gly Ala Ser Ile Ile Thr Phe His Pro Glu Ala Ser           
                85                  90                  95                

gag cat gtt gac cgc acg ctg caa ctg att aaa gaa aat ggc tgt aaa        336
Glu His Val Asp Arg Thr Leu Gln Leu Ile Lys Glu Asn Gly Cys Lys           
            100                 105                 110                   

gcg ggt ctg gta ttt aac ccg gcg aca cct ctg agc tat ctg gat tac        384
Ala Gly Leu Val Phe Asn Pro Ala Thr Pro Leu Ser Tyr Leu Asp Tyr           
        115                 120                 125                       

gtg atg gat aag ctg gat gtg atc ctg ctg atg tcc gtc aac cct ggt        432
Val Met Asp Lys Leu Asp Val Ile Leu Leu Met Ser Val Asn Pro Gly           
    130                 135                 140                           

ttc ggc ggt cag tct ttc att cct caa aca ctg gat aaa ctg cgc gaa        480
Phe Gly Gly Gln Ser Phe Ile Pro Gln Thr Leu Asp Lys Leu Arg Glu           
145                 150                 155                 160           

gta cgt cgc cgt atc gac gag tct ggc ttt gac att cga cta gaa gtg        528
Val Arg Arg Arg Ile Asp Glu Ser Gly Phe Asp Ile Arg Leu Glu Val           
                165                 170                 175               

gac ggt ggc gtg aag gtg aac aac att ggc gaa atc gct gcg gcg ggc        576
Asp Gly Gly Val Lys Val Asn Asn Ile Gly Glu Ile Ala Ala Ala Gly           
            180                 185                 190                   

gcg gat atg ttc gtc gcc ggt tcg gca atc ttc gac cag cca gac tac        624
Ala Asp Met Phe Val Ala Gly Ser Ala Ile Phe Asp Gln Pro Asp Tyr           
        195                 200                 205                       

aaa aaa gtc att gat gaa atg cgc agt gaa ctg gca aag gta agt cat        672
Lys Lys Val Ile Asp Glu Met Arg Ser Glu Leu Ala Lys Val Ser His           
    210                 215                 220                           

gaa taa                                                                678
Glu                                                                       
225                                                                       


<210>  6
<211>  225
<212>  PRT
<213>  Escherichia coli

<400>  6

Met Lys Gln Tyr Leu Ile Ala Pro Ser Ile Leu Ser Ala Asp Phe Ala 
1               5                   10                  15      


Arg Leu Gly Glu Asp Thr Ala Lys Ala Leu Ala Ala Gly Ala Asp Val 
            20                  25                  30          


Val His Phe Asp Val Met Asp Asn His Tyr Val Pro Asn Leu Thr Ile 
        35                  40                  45              


Gly Pro Met Val Leu Lys Ser Leu Arg Asn Tyr Gly Ile Thr Ala Pro 
    50                  55                  60                  


Ile Asp Val His Leu Met Val Lys Pro Val Asp Arg Ile Val Pro Asp 
65                  70                  75                  80  


Phe Ala Ala Ala Gly Ala Ser Ile Ile Thr Phe His Pro Glu Ala Ser 
                85                  90                  95      


Glu His Val Asp Arg Thr Leu Gln Leu Ile Lys Glu Asn Gly Cys Lys 
            100                 105                 110         


Ala Gly Leu Val Phe Asn Pro Ala Thr Pro Leu Ser Tyr Leu Asp Tyr 
        115                 120                 125             


Val Met Asp Lys Leu Asp Val Ile Leu Leu Met Ser Val Asn Pro Gly 
    130                 135                 140                 


Phe Gly Gly Gln Ser Phe Ile Pro Gln Thr Leu Asp Lys Leu Arg Glu 
145                 150                 155                 160 


Val Arg Arg Arg Ile Asp Glu Ser Gly Phe Asp Ile Arg Leu Glu Val 
                165                 170                 175     


Asp Gly Gly Val Lys Val Asn Asn Ile Gly Glu Ile Ala Ala Ala Gly 
            180                 185                 190         


Ala Asp Met Phe Val Ala Gly Ser Ala Ile Phe Asp Gln Pro Asp Tyr 
        195                 200                 205             


Lys Lys Val Ile Asp Glu Met Arg Ser Glu Leu Ala Lys Val Ser His 
    210                 215                 220                 


Glu 
225 


<210>  7
<211>  660
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(660)

<400>  7
atg acg cag gat gaa ttg aaa aaa gca gta gga tgg gcg gca ctt cag         48
Met Thr Gln Asp Glu Leu Lys Lys Ala Val Gly Trp Ala Ala Leu Gln           
1               5                   10                  15                

tat gtt cag ccc ggc acc att gtt ggt gta ggt aca ggt tcc acc gcc         96
Tyr Val Gln Pro Gly Thr Ile Val Gly Val Gly Thr Gly Ser Thr Ala           
            20                  25                  30                    

gca cac ttt att gac gcg ctc ggt aca atg aaa ggc cag att gaa ggg        144
Ala His Phe Ile Asp Ala Leu Gly Thr Met Lys Gly Gln Ile Glu Gly           
        35                  40                  45                        

gcc gtt tcc agt tca gat gct tcc act gaa aaa ctg aaa agc ctc ggc        192
Ala Val Ser Ser Ser Asp Ala Ser Thr Glu Lys Leu Lys Ser Leu Gly           
    50                  55                  60                            

att cac gtt ttt gat ctc aac gaa gtc gac agc ctt ggc atc tac gtt        240
Ile His Val Phe Asp Leu Asn Glu Val Asp Ser Leu Gly Ile Tyr Val           
65                  70                  75                  80            

gat ggc gca gat gaa atc aac ggc cac atg caa atg atc aaa ggc ggc        288
Asp Gly Ala Asp Glu Ile Asn Gly His Met Gln Met Ile Lys Gly Gly           
                85                  90                  95                

ggc gcg gcg ctg acc cgt gaa aaa atc att gct tcg gtt gca gaa aaa        336
Gly Ala Ala Leu Thr Arg Glu Lys Ile Ile Ala Ser Val Ala Glu Lys           
            100                 105                 110                   

ttt atc tgt att gca gac gct tcc aag cag gtt gat att ctg ggt aaa        384
Phe Ile Cys Ile Ala Asp Ala Ser Lys Gln Val Asp Ile Leu Gly Lys           
        115                 120                 125                       

ttc ccg ctg cca gta gaa gtt atc ccg atg gca cgt agt gca gtg gcg        432
Phe Pro Leu Pro Val Glu Val Ile Pro Met Ala Arg Ser Ala Val Ala           
    130                 135                 140                           

cgt cag ctg gtg aaa ctg ggc ggt cgt ccg gaa tac cgt cag ggc gtg        480
Arg Gln Leu Val Lys Leu Gly Gly Arg Pro Glu Tyr Arg Gln Gly Val           
145                 150                 155                 160           

gtg acc gat aat ggc aac gtg atc ctc gac gtc cac ggc atg gaa atc        528
Val Thr Asp Asn Gly Asn Val Ile Leu Asp Val His Gly Met Glu Ile           
                165                 170                 175               

ctt gac ccg ata gcg atg gaa aac gcc ata aat gcg att cct ggc gtg        576
Leu Asp Pro Ile Ala Met Glu Asn Ala Ile Asn Ala Ile Pro Gly Val           
            180                 185                 190                   

gtg act gtt ggc ttg ttt gct aac cgt ggc gcg gac gtt gcg ctg att        624
Val Thr Val Gly Leu Phe Ala Asn Arg Gly Ala Asp Val Ala Leu Ile           
        195                 200                 205                       

ggc aca cct gac ggt gtc aaa acc att gtg aaa tga                        660
Gly Thr Pro Asp Gly Val Lys Thr Ile Val Lys                               
    210                 215                                               


<210>  8
<211>  219
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Thr Gln Asp Glu Leu Lys Lys Ala Val Gly Trp Ala Ala Leu Gln 
1               5                   10                  15      


Tyr Val Gln Pro Gly Thr Ile Val Gly Val Gly Thr Gly Ser Thr Ala 
            20                  25                  30          


Ala His Phe Ile Asp Ala Leu Gly Thr Met Lys Gly Gln Ile Glu Gly 
        35                  40                  45              


Ala Val Ser Ser Ser Asp Ala Ser Thr Glu Lys Leu Lys Ser Leu Gly 
    50                  55                  60                  


Ile His Val Phe Asp Leu Asn Glu Val Asp Ser Leu Gly Ile Tyr Val 
65                  70                  75                  80  


Asp Gly Ala Asp Glu Ile Asn Gly His Met Gln Met Ile Lys Gly Gly 
                85                  90                  95      


Gly Ala Ala Leu Thr Arg Glu Lys Ile Ile Ala Ser Val Ala Glu Lys 
            100                 105                 110         


Phe Ile Cys Ile Ala Asp Ala Ser Lys Gln Val Asp Ile Leu Gly Lys 
        115                 120                 125             


Phe Pro Leu Pro Val Glu Val Ile Pro Met Ala Arg Ser Ala Val Ala 
    130                 135                 140                 


Arg Gln Leu Val Lys Leu Gly Gly Arg Pro Glu Tyr Arg Gln Gly Val 
145                 150                 155                 160 


Val Thr Asp Asn Gly Asn Val Ile Leu Asp Val His Gly Met Glu Ile 
                165                 170                 175     


Leu Asp Pro Ile Ala Met Glu Asn Ala Ile Asn Ala Ile Pro Gly Val 
            180                 185                 190         


Val Thr Val Gly Leu Phe Ala Asn Arg Gly Ala Asp Val Ala Leu Ile 
        195                 200                 205             


Gly Thr Pro Asp Gly Val Lys Thr Ile Val Lys 
    210                 215                 


<210>  9
<211>  954
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(954)

<400>  9
atg acg gac aaa ttg acc tcc ctt cgt cag tac acc acc gta gtg gcc         48
Met Thr Asp Lys Leu Thr Ser Leu Arg Gln Tyr Thr Thr Val Val Ala           
1               5                   10                  15                

gac act ggg gac atc gcg gca atg aag ctg tat caa ccg cag gat gcc         96
Asp Thr Gly Asp Ile Ala Ala Met Lys Leu Tyr Gln Pro Gln Asp Ala           
            20                  25                  30                    

aca acc aac cct tct ctc att ctt aac gca gcg cag att ccg gaa tac        144
Thr Thr Asn Pro Ser Leu Ile Leu Asn Ala Ala Gln Ile Pro Glu Tyr           
        35                  40                  45                        

cgt aag ttg att gat gat gct gtc gcc tgg gcg aaa cag cag agc aac        192
Arg Lys Leu Ile Asp Asp Ala Val Ala Trp Ala Lys Gln Gln Ser Asn           
    50                  55                  60                            

gat cgc gcg cag cag atc gtg gac gcg acc gac aaa ctg gca gta aat        240
Asp Arg Ala Gln Gln Ile Val Asp Ala Thr Asp Lys Leu Ala Val Asn           
65                  70                  75                  80            

att ggt ctg gaa atc ctg aaa ctg gtt ccg ggc cgt atc tca act gaa        288
Ile Gly Leu Glu Ile Leu Lys Leu Val Pro Gly Arg Ile Ser Thr Glu           
                85                  90                  95                

gtt gat gcg cgt ctt tcc tat gac acc gaa gcg tca att gcg aaa gca        336
Val Asp Ala Arg Leu Ser Tyr Asp Thr Glu Ala Ser Ile Ala Lys Ala           
            100                 105                 110                   

aaa cgc ctg atc aaa ctc tac aac gat gct ggt att agc aac gat cgt        384
Lys Arg Leu Ile Lys Leu Tyr Asn Asp Ala Gly Ile Ser Asn Asp Arg           
        115                 120                 125                       

att ctg atc aaa ctg gct tct acc tgg cag ggt atc cgt gct gca gaa        432
Ile Leu Ile Lys Leu Ala Ser Thr Trp Gln Gly Ile Arg Ala Ala Glu           
    130                 135                 140                           

cag ctg gaa aaa gaa ggc atc aac tgt aac ctg acc ctg ctg ttc tcc        480
Gln Leu Glu Lys Glu Gly Ile Asn Cys Asn Leu Thr Leu Leu Phe Ser           
145                 150                 155                 160           

ttc gct cag gct cgt gct tgt gcg gaa gcg ggc gtg ttc ctg atc tcg        528
Phe Ala Gln Ala Arg Ala Cys Ala Glu Ala Gly Val Phe Leu Ile Ser           
                165                 170                 175               

ccg ttt gtt ggc cgt att ctt gac tgg tac aaa gcg aat acc gat aag        576
Pro Phe Val Gly Arg Ile Leu Asp Trp Tyr Lys Ala Asn Thr Asp Lys           
            180                 185                 190                   

aaa gag tac gct ccg gca gaa gat ccg ggc gtg gtt tct gta tct gaa        624
Lys Glu Tyr Ala Pro Ala Glu Asp Pro Gly Val Val Ser Val Ser Glu           
        195                 200                 205                       

atc tac cag tac tac aaa gag cac ggt tat gaa acc gtg gtt atg ggc        672
Ile Tyr Gln Tyr Tyr Lys Glu His Gly Tyr Glu Thr Val Val Met Gly           
    210                 215                 220                           

gca agc ttc cgt aac atc ggc gaa att ctg gaa ctg gca ggc tgc gac        720
Ala Ser Phe Arg Asn Ile Gly Glu Ile Leu Glu Leu Ala Gly Cys Asp           
225                 230                 235                 240           

cgt ctg acc atc gca ccg gca ctg ctg aaa gag ctg gcg gag agc gaa        768
Arg Leu Thr Ile Ala Pro Ala Leu Leu Lys Glu Leu Ala Glu Ser Glu           
                245                 250                 255               

ggg gct atc gaa cgt aaa ctg tct tac acc ggc gaa gtg aaa gcg cgt        816
Gly Ala Ile Glu Arg Lys Leu Ser Tyr Thr Gly Glu Val Lys Ala Arg           
            260                 265                 270                   

ccg gcg cgt atc act gag tcc gag ttc ctg tgg cag cac aac cag gat        864
Pro Ala Arg Ile Thr Glu Ser Glu Phe Leu Trp Gln His Asn Gln Asp           
        275                 280                 285                       

cca atg gca gta gat aaa ctg gcg gaa ggt atc cgt aag ttt gct att        912
Pro Met Ala Val Asp Lys Leu Ala Glu Gly Ile Arg Lys Phe Ala Ile           
    290                 295                 300                           

gac cag gaa aaa ctg gaa aaa atg atc ggc gat ctg ctg taa                954
Asp Gln Glu Lys Leu Glu Lys Met Ile Gly Asp Leu Leu                       
305                 310                 315                               


<210>  10
<211>  317
<212>  PRT
<213>  Escherichia coli

<400>  10

Met Thr Asp Lys Leu Thr Ser Leu Arg Gln Tyr Thr Thr Val Val Ala 
1               5                   10                  15      


Asp Thr Gly Asp Ile Ala Ala Met Lys Leu Tyr Gln Pro Gln Asp Ala 
            20                  25                  30          


Thr Thr Asn Pro Ser Leu Ile Leu Asn Ala Ala Gln Ile Pro Glu Tyr 
        35                  40                  45              


Arg Lys Leu Ile Asp Asp Ala Val Ala Trp Ala Lys Gln Gln Ser Asn 
    50                  55                  60                  


Asp Arg Ala Gln Gln Ile Val Asp Ala Thr Asp Lys Leu Ala Val Asn 
65                  70                  75                  80  


Ile Gly Leu Glu Ile Leu Lys Leu Val Pro Gly Arg Ile Ser Thr Glu 
                85                  90                  95      


Val Asp Ala Arg Leu Ser Tyr Asp Thr Glu Ala Ser Ile Ala Lys Ala 
            100                 105                 110         


Lys Arg Leu Ile Lys Leu Tyr Asn Asp Ala Gly Ile Ser Asn Asp Arg 
        115                 120                 125             


Ile Leu Ile Lys Leu Ala Ser Thr Trp Gln Gly Ile Arg Ala Ala Glu 
    130                 135                 140                 


Gln Leu Glu Lys Glu Gly Ile Asn Cys Asn Leu Thr Leu Leu Phe Ser 
145                 150                 155                 160 


Phe Ala Gln Ala Arg Ala Cys Ala Glu Ala Gly Val Phe Leu Ile Ser 
                165                 170                 175     


Pro Phe Val Gly Arg Ile Leu Asp Trp Tyr Lys Ala Asn Thr Asp Lys 
            180                 185                 190         


Lys Glu Tyr Ala Pro Ala Glu Asp Pro Gly Val Val Ser Val Ser Glu 
        195                 200                 205             


Ile Tyr Gln Tyr Tyr Lys Glu His Gly Tyr Glu Thr Val Val Met Gly 
    210                 215                 220                 


Ala Ser Phe Arg Asn Ile Gly Glu Ile Leu Glu Leu Ala Gly Cys Asp 
225                 230                 235                 240 


Arg Leu Thr Ile Ala Pro Ala Leu Leu Lys Glu Leu Ala Glu Ser Glu 
                245                 250                 255     


Gly Ala Ile Glu Arg Lys Leu Ser Tyr Thr Gly Glu Val Lys Ala Arg 
            260                 265                 270         


Pro Ala Arg Ile Thr Glu Ser Glu Phe Leu Trp Gln His Asn Gln Asp 
        275                 280                 285             


Pro Met Ala Val Asp Lys Leu Ala Glu Gly Ile Arg Lys Phe Ala Ile 
    290                 295                 300                 


Asp Gln Glu Lys Leu Glu Lys Met Ile Gly Asp Leu Leu 
305                 310                 315         


<210>  11
<211>  1992
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(1992)

<400>  11
atg tcc tca cgt aaa gag ctt gcc aat gct att cgt gcg ctg agc atg         48
Met Ser Ser Arg Lys Glu Leu Ala Asn Ala Ile Arg Ala Leu Ser Met           
1               5                   10                  15                

gac gca gta cag aaa gcc aaa tcc ggt cac ccg ggt gcc cct atg ggt         96
Asp Ala Val Gln Lys Ala Lys Ser Gly His Pro Gly Ala Pro Met Gly           
            20                  25                  30                    

atg gct gac att gcc gaa gtc ctg tgg cgt gat ttc ctg aaa cac aac        144
Met Ala Asp Ile Ala Glu Val Leu Trp Arg Asp Phe Leu Lys His Asn           
        35                  40                  45                        

ccg cag aat ccg tcc tgg gct gac cgt gac cgc ttc gtg ctg tcc aac        192
Pro Gln Asn Pro Ser Trp Ala Asp Arg Asp Arg Phe Val Leu Ser Asn           
    50                  55                  60                            

ggc cac ggc tcc atg ctg atc tac agc ctg ctg cac ctc acc ggt tac        240
Gly His Gly Ser Met Leu Ile Tyr Ser Leu Leu His Leu Thr Gly Tyr           
65                  70                  75                  80            

gat ctg ccg atg gaa gaa ctg aaa aac ttc cgt cag ctg cac tct aaa        288
Asp Leu Pro Met Glu Glu Leu Lys Asn Phe Arg Gln Leu His Ser Lys           
                85                  90                  95                

act ccg ggt cac ccg gaa gtg ggt tac acc gct ggt gtg gaa acc acc        336
Thr Pro Gly His Pro Glu Val Gly Tyr Thr Ala Gly Val Glu Thr Thr           
            100                 105                 110                   

acc ggt ccg ctg ggt cag ggt att gcc aac gca gtc ggt atg gcg att        384
Thr Gly Pro Leu Gly Gln Gly Ile Ala Asn Ala Val Gly Met Ala Ile           
        115                 120                 125                       

gca gaa aaa acg ctg gcg gcg cag ttt aac cgt ccg ggc cac gac att        432
Ala Glu Lys Thr Leu Ala Ala Gln Phe Asn Arg Pro Gly His Asp Ile           
    130                 135                 140                           

gtc gac cac tac acc tac gcc ttc atg ggc gac ggc tgc atg atg gaa        480
Val Asp His Tyr Thr Tyr Ala Phe Met Gly Asp Gly Cys Met Met Glu           
145                 150                 155                 160           

ggc atc tcc cac gaa gtt tgc tct ctg gcg ggt acg ctg aag ctg ggt        528
Gly Ile Ser His Glu Val Cys Ser Leu Ala Gly Thr Leu Lys Leu Gly           
                165                 170                 175               

aaa ctg att gca ttc tac gat gac aac ggt att tct atc gat ggt cac        576
Lys Leu Ile Ala Phe Tyr Asp Asp Asn Gly Ile Ser Ile Asp Gly His           
            180                 185                 190                   

gtt gaa ggc tgg ttc acc gac gac acc gca atg cgt ttc gaa gct tac        624
Val Glu Gly Trp Phe Thr Asp Asp Thr Ala Met Arg Phe Glu Ala Tyr           
        195                 200                 205                       

ggc tgg cac gtt att cgc gac atc gac ggt cat gac gcg gca tct atc        672
Gly Trp His Val Ile Arg Asp Ile Asp Gly His Asp Ala Ala Ser Ile           
    210                 215                 220                           

aaa cgc gca gta gaa gaa gcg cgc gca gtg act gac aaa cct tcc ctg        720
Lys Arg Ala Val Glu Glu Ala Arg Ala Val Thr Asp Lys Pro Ser Leu           
225                 230                 235                 240           

ctg atg tgc aaa acc atc atc ggt ttc ggt tcc ccg aac aaa gcc ggt        768
Leu Met Cys Lys Thr Ile Ile Gly Phe Gly Ser Pro Asn Lys Ala Gly           
                245                 250                 255               

acc cac gac tcc cac ggt gcg ccg ctg ggc gac gct gaa att gcc ctg        816
Thr His Asp Ser His Gly Ala Pro Leu Gly Asp Ala Glu Ile Ala Leu           
            260                 265                 270                   

acc cgc gaa caa ctg ggc tgg aaa tat gcg ccg ttc gaa atc ccg tct        864
Thr Arg Glu Gln Leu Gly Trp Lys Tyr Ala Pro Phe Glu Ile Pro Ser           
        275                 280                 285                       

gaa atc tat gct cag tgg gat gcg aaa gaa gca ggc cag gcg aaa gaa        912
Glu Ile Tyr Ala Gln Trp Asp Ala Lys Glu Ala Gly Gln Ala Lys Glu           
    290                 295                 300                           

tcc gca tgg aac gag aaa ttc gct gct tac gcg aaa gct tat ccg cag        960
Ser Ala Trp Asn Glu Lys Phe Ala Ala Tyr Ala Lys Ala Tyr Pro Gln           
305                 310                 315                 320           

gaa gcc gct gaa ttt acc cgc cgt atg aaa ggc gaa atg ccg tct gac       1008
Glu Ala Ala Glu Phe Thr Arg Arg Met Lys Gly Glu Met Pro Ser Asp           
                325                 330                 335               

ttc gac gct aaa gcg aaa gag ttc atc gct aaa ctg cag gct aat ccg       1056
Phe Asp Ala Lys Ala Lys Glu Phe Ile Ala Lys Leu Gln Ala Asn Pro           
            340                 345                 350                   

gcg aaa atc gcc agc cgt aaa gcg tct cag aat gct atc gaa gcg ttc       1104
Ala Lys Ile Ala Ser Arg Lys Ala Ser Gln Asn Ala Ile Glu Ala Phe           
        355                 360                 365                       

ggt ccg ctg ttg ccg gaa ttc ctc ggc ggt tct gct gac ctg gcg ccg       1152
Gly Pro Leu Leu Pro Glu Phe Leu Gly Gly Ser Ala Asp Leu Ala Pro           
    370                 375                 380                           

tct aac ctg acc ctg tgg tct ggt tct aaa gca atc aac gaa gat gct       1200
Ser Asn Leu Thr Leu Trp Ser Gly Ser Lys Ala Ile Asn Glu Asp Ala           
385                 390                 395                 400           

gcg ggt aac tac atc cac tac ggt gtt cgc gag ttc ggt atg acc gcg       1248
Ala Gly Asn Tyr Ile His Tyr Gly Val Arg Glu Phe Gly Met Thr Ala           
                405                 410                 415               

att gct aac ggt atc tcc ctg cac ggt ggc ttc ctg ccg tac acc tcc       1296
Ile Ala Asn Gly Ile Ser Leu His Gly Gly Phe Leu Pro Tyr Thr Ser           
            420                 425                 430                   

acc ttc ctg atg ttc gtg gaa tac gca cgt aac gcc gta cgt atg gct       1344
Thr Phe Leu Met Phe Val Glu Tyr Ala Arg Asn Ala Val Arg Met Ala           
        435                 440                 445                       

gcg ctg atg aaa cag cgt cag gtg atg gtt tac acc cac gac tcc atc       1392
Ala Leu Met Lys Gln Arg Gln Val Met Val Tyr Thr His Asp Ser Ile           
    450                 455                 460                           

ggt ctg ggc gaa gac ggc ccg act cac cag ccg gtt gag cag gtc gct       1440
Gly Leu Gly Glu Asp Gly Pro Thr His Gln Pro Val Glu Gln Val Ala           
465                 470                 475                 480           

tct ctg cgc gta acc ccg aac atg tct aca tgg cgt ccg tgt gac cag       1488
Ser Leu Arg Val Thr Pro Asn Met Ser Thr Trp Arg Pro Cys Asp Gln           
                485                 490                 495               

gtt gaa tcc gcg gtc gcg tgg aaa tac ggt gtt gag cgt cag gac ggc       1536
Val Glu Ser Ala Val Ala Trp Lys Tyr Gly Val Glu Arg Gln Asp Gly           
            500                 505                 510                   

ccg acc gca ctg atc ctc tcc cgt cag aac ctg gcg cag cag gaa cga       1584
Pro Thr Ala Leu Ile Leu Ser Arg Gln Asn Leu Ala Gln Gln Glu Arg           
        515                 520                 525                       

act gaa gag caa ctg gca aac atc gcg cgc ggt ggt tat gtg ctg aaa       1632
Thr Glu Glu Gln Leu Ala Asn Ile Ala Arg Gly Gly Tyr Val Leu Lys           
    530                 535                 540                           

gac tgc gcc ggt cag ccg gaa ctg att ttc atc gct acc ggt tca gaa       1680
Asp Cys Ala Gly Gln Pro Glu Leu Ile Phe Ile Ala Thr Gly Ser Glu           
545                 550                 555                 560           

gtt gaa ctg gct gtt gct gcc tac gaa aaa ctg act gcc gaa ggc gtg       1728
Val Glu Leu Ala Val Ala Ala Tyr Glu Lys Leu Thr Ala Glu Gly Val           
                565                 570                 575               

aaa gcg cgc gtg gtg tcc atg ccg tct acc gac gca ttt gac aag cag       1776
Lys Ala Arg Val Val Ser Met Pro Ser Thr Asp Ala Phe Asp Lys Gln           
            580                 585                 590                   

gat gct gct tac cgt gaa tcc gta ctg ccg aaa gcg gtt act gca cgc       1824
Asp Ala Ala Tyr Arg Glu Ser Val Leu Pro Lys Ala Val Thr Ala Arg           
        595                 600                 605                       

gtt gct gta gaa gcg ggt att gct gac tac tgg tac aag tat gtt ggc       1872
Val Ala Val Glu Ala Gly Ile Ala Asp Tyr Trp Tyr Lys Tyr Val Gly           
    610                 615                 620                           

ctg aac ggt gct atc gtc ggt atg acc acc ttc ggt gaa tct gct ccg       1920
Leu Asn Gly Ala Ile Val Gly Met Thr Thr Phe Gly Glu Ser Ala Pro           
625                 630                 635                 640           

gca gag ctg ctg ttt gaa gag ttc ggc ttc act gtt gat aac gtt gtt       1968
Ala Glu Leu Leu Phe Glu Glu Phe Gly Phe Thr Val Asp Asn Val Val           
                645                 650                 655               

gcg aaa gca aaa gaa ctg ctg taa                                       1992
Ala Lys Ala Lys Glu Leu Leu                                               
            660                                                           


<210>  12
<211>  663
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Ser Ser Arg Lys Glu Leu Ala Asn Ala Ile Arg Ala Leu Ser Met 
1               5                   10                  15      


Asp Ala Val Gln Lys Ala Lys Ser Gly His Pro Gly Ala Pro Met Gly 
            20                  25                  30          


Met Ala Asp Ile Ala Glu Val Leu Trp Arg Asp Phe Leu Lys His Asn 
        35                  40                  45              


Pro Gln Asn Pro Ser Trp Ala Asp Arg Asp Arg Phe Val Leu Ser Asn 
    50                  55                  60                  


Gly His Gly Ser Met Leu Ile Tyr Ser Leu Leu His Leu Thr Gly Tyr 
65                  70                  75                  80  


Asp Leu Pro Met Glu Glu Leu Lys Asn Phe Arg Gln Leu His Ser Lys 
                85                  90                  95      


Thr Pro Gly His Pro Glu Val Gly Tyr Thr Ala Gly Val Glu Thr Thr 
            100                 105                 110         


Thr Gly Pro Leu Gly Gln Gly Ile Ala Asn Ala Val Gly Met Ala Ile 
        115                 120                 125             


Ala Glu Lys Thr Leu Ala Ala Gln Phe Asn Arg Pro Gly His Asp Ile 
    130                 135                 140                 


Val Asp His Tyr Thr Tyr Ala Phe Met Gly Asp Gly Cys Met Met Glu 
145                 150                 155                 160 


Gly Ile Ser His Glu Val Cys Ser Leu Ala Gly Thr Leu Lys Leu Gly 
                165                 170                 175     


Lys Leu Ile Ala Phe Tyr Asp Asp Asn Gly Ile Ser Ile Asp Gly His 
            180                 185                 190         


Val Glu Gly Trp Phe Thr Asp Asp Thr Ala Met Arg Phe Glu Ala Tyr 
        195                 200                 205             


Gly Trp His Val Ile Arg Asp Ile Asp Gly His Asp Ala Ala Ser Ile 
    210                 215                 220                 


Lys Arg Ala Val Glu Glu Ala Arg Ala Val Thr Asp Lys Pro Ser Leu 
225                 230                 235                 240 


Leu Met Cys Lys Thr Ile Ile Gly Phe Gly Ser Pro Asn Lys Ala Gly 
                245                 250                 255     


Thr His Asp Ser His Gly Ala Pro Leu Gly Asp Ala Glu Ile Ala Leu 
            260                 265                 270         


Thr Arg Glu Gln Leu Gly Trp Lys Tyr Ala Pro Phe Glu Ile Pro Ser 
        275                 280                 285             


Glu Ile Tyr Ala Gln Trp Asp Ala Lys Glu Ala Gly Gln Ala Lys Glu 
    290                 295                 300                 


Ser Ala Trp Asn Glu Lys Phe Ala Ala Tyr Ala Lys Ala Tyr Pro Gln 
305                 310                 315                 320 


Glu Ala Ala Glu Phe Thr Arg Arg Met Lys Gly Glu Met Pro Ser Asp 
                325                 330                 335     


Phe Asp Ala Lys Ala Lys Glu Phe Ile Ala Lys Leu Gln Ala Asn Pro 
            340                 345                 350         


Ala Lys Ile Ala Ser Arg Lys Ala Ser Gln Asn Ala Ile Glu Ala Phe 
        355                 360                 365             


Gly Pro Leu Leu Pro Glu Phe Leu Gly Gly Ser Ala Asp Leu Ala Pro 
    370                 375                 380                 


Ser Asn Leu Thr Leu Trp Ser Gly Ser Lys Ala Ile Asn Glu Asp Ala 
385                 390                 395                 400 


Ala Gly Asn Tyr Ile His Tyr Gly Val Arg Glu Phe Gly Met Thr Ala 
                405                 410                 415     


Ile Ala Asn Gly Ile Ser Leu His Gly Gly Phe Leu Pro Tyr Thr Ser 
            420                 425                 430         


Thr Phe Leu Met Phe Val Glu Tyr Ala Arg Asn Ala Val Arg Met Ala 
        435                 440                 445             


Ala Leu Met Lys Gln Arg Gln Val Met Val Tyr Thr His Asp Ser Ile 
    450                 455                 460                 


Gly Leu Gly Glu Asp Gly Pro Thr His Gln Pro Val Glu Gln Val Ala 
465                 470                 475                 480 


Ser Leu Arg Val Thr Pro Asn Met Ser Thr Trp Arg Pro Cys Asp Gln 
                485                 490                 495     


Val Glu Ser Ala Val Ala Trp Lys Tyr Gly Val Glu Arg Gln Asp Gly 
            500                 505                 510         


Pro Thr Ala Leu Ile Leu Ser Arg Gln Asn Leu Ala Gln Gln Glu Arg 
        515                 520                 525             


Thr Glu Glu Gln Leu Ala Asn Ile Ala Arg Gly Gly Tyr Val Leu Lys 
    530                 535                 540                 


Asp Cys Ala Gly Gln Pro Glu Leu Ile Phe Ile Ala Thr Gly Ser Glu 
545                 550                 555                 560 


Val Glu Leu Ala Val Ala Ala Tyr Glu Lys Leu Thr Ala Glu Gly Val 
                565                 570                 575     


Lys Ala Arg Val Val Ser Met Pro Ser Thr Asp Ala Phe Asp Lys Gln 
            580                 585                 590         


Asp Ala Ala Tyr Arg Glu Ser Val Leu Pro Lys Ala Val Thr Ala Arg 
        595                 600                 605             


Val Ala Val Glu Ala Gly Ile Ala Asp Tyr Trp Tyr Lys Tyr Val Gly 
    610                 615                 620                 


Leu Asn Gly Ala Ile Val Gly Met Thr Thr Phe Gly Glu Ser Ala Pro 
625                 630                 635                 640 


Ala Glu Leu Leu Phe Glu Glu Phe Gly Phe Thr Val Asp Asn Val Val 
                645                 650                 655     


Ala Lys Ala Lys Glu Leu Leu 
            660             


<210>  13
<211>  633
<212>  DNA
<213>  Bacillus subtilis


<220>
<221>  CDS
<222>  (1)..(633)

<400>  13
atg gaa tta cag ctt gca tta gac ctc gtc aac atc cca gaa gcc att         48
Met Glu Leu Gln Leu Ala Leu Asp Leu Val Asn Ile Pro Glu Ala Ile           
1               5                   10                  15                

gag ctc gtc aaa gag gta gaa caa tac atc gac gta gtt gaa atc gga         96
Glu Leu Val Lys Glu Val Glu Gln Tyr Ile Asp Val Val Glu Ile Gly           
            20                  25                  30                    

aca ccg gtc gtc att aat gaa ggc cta aga gcc gtt aaa gaa tta aaa        144
Thr Pro Val Val Ile Asn Glu Gly Leu Arg Ala Val Lys Glu Leu Lys           
        35                  40                  45                        

gaa gca ttt cct caa ttg aag gtt ctt gca gac ctg aaa atc atg gat        192
Glu Ala Phe Pro Gln Leu Lys Val Leu Ala Asp Leu Lys Ile Met Asp           
    50                  55                  60                            

gcc gga ggc tac gaa att atg aaa gcg tcg gaa gca ggc gct gac atc        240
Ala Gly Gly Tyr Glu Ile Met Lys Ala Ser Glu Ala Gly Ala Asp Ile           
65                  70                  75                  80            

atc acc gtt tta ggg gct aca gac gac gca acg att aaa ggc gca gta        288
Ile Thr Val Leu Gly Ala Thr Asp Asp Ala Thr Ile Lys Gly Ala Val           
                85                  90                  95                

gaa gaa gcc aaa aaa caa aag aag aaa atc tta gtg gac atg att aac        336
Glu Glu Ala Lys Lys Gln Lys Lys Lys Ile Leu Val Asp Met Ile Asn           
            100                 105                 110                   

gtg aaa gat atc gag tcc cgt gcg caa gaa att gac gca ctc ggt gtt        384
Val Lys Asp Ile Glu Ser Arg Ala Gln Glu Ile Asp Ala Leu Gly Val           
        115                 120                 125                       

gac tac atc tgc gtc cac act ggc tat gat ctt caa gca gag ggc aag        432
Asp Tyr Ile Cys Val His Thr Gly Tyr Asp Leu Gln Ala Glu Gly Lys           
    130                 135                 140                           

aac tct ttc gaa gaa tta acg aca atc aaa aac acc gta aaa aac gca        480
Asn Ser Phe Glu Glu Leu Thr Thr Ile Lys Asn Thr Val Lys Asn Ala           
145                 150                 155                 160           

aaa acc gca atc gcg ggc ggc atc aaa ctt gat aca ctg cca gaa gtg        528
Lys Thr Ala Ile Ala Gly Gly Ile Lys Leu Asp Thr Leu Pro Glu Val           
                165                 170                 175               

atc aag caa aac ccc gac ctt gtc att gtt ggg ggc gga att aca agc        576
Ile Lys Gln Asn Pro Asp Leu Val Ile Val Gly Gly Gly Ile Thr Ser           
            180                 185                 190                   

gca gct gat aag gca gaa aca gct tca aaa atg aag cag ctg att gtc        624
Ala Ala Asp Lys Ala Glu Thr Ala Ser Lys Met Lys Gln Leu Ile Val           
        195                 200                 205                       

caa gga taa                                                            633
Gln Gly                                                                   
    210                                                                   


<210>  14
<211>  210
<212>  PRT
<213>  Bacillus subtilis

<400>  14

Met Glu Leu Gln Leu Ala Leu Asp Leu Val Asn Ile Pro Glu Ala Ile 
1               5                   10                  15      


Glu Leu Val Lys Glu Val Glu Gln Tyr Ile Asp Val Val Glu Ile Gly 
            20                  25                  30          


Thr Pro Val Val Ile Asn Glu Gly Leu Arg Ala Val Lys Glu Leu Lys 
        35                  40                  45              


Glu Ala Phe Pro Gln Leu Lys Val Leu Ala Asp Leu Lys Ile Met Asp 
    50                  55                  60                  


Ala Gly Gly Tyr Glu Ile Met Lys Ala Ser Glu Ala Gly Ala Asp Ile 
65                  70                  75                  80  


Ile Thr Val Leu Gly Ala Thr Asp Asp Ala Thr Ile Lys Gly Ala Val 
                85                  90                  95      


Glu Glu Ala Lys Lys Gln Lys Lys Lys Ile Leu Val Asp Met Ile Asn 
            100                 105                 110         


Val Lys Asp Ile Glu Ser Arg Ala Gln Glu Ile Asp Ala Leu Gly Val 
        115                 120                 125             


Asp Tyr Ile Cys Val His Thr Gly Tyr Asp Leu Gln Ala Glu Gly Lys 
    130                 135                 140                 


Asn Ser Phe Glu Glu Leu Thr Thr Ile Lys Asn Thr Val Lys Asn Ala 
145                 150                 155                 160 


Lys Thr Ala Ile Ala Gly Gly Ile Lys Leu Asp Thr Leu Pro Glu Val 
                165                 170                 175     


Ile Lys Gln Asn Pro Asp Leu Val Ile Val Gly Gly Gly Ile Thr Ser 
            180                 185                 190         


Ala Ala Asp Lys Ala Glu Thr Ala Ser Lys Met Lys Gln Leu Ile Val 
        195                 200                 205             


Gln Gly 
    210 


<210>  15
<211>  687
<212>  DNA
<213>  Methylobacillus flagellatus


<220>
<221>  CDS
<222>  (1)..(687)

<400>  15
gtg gca aaa cca tta gtt caa atg gca tta gat tca cta gat ttc gat         48
Val Ala Lys Pro Leu Val Gln Met Ala Leu Asp Ser Leu Asp Phe Asp           
1               5                   10                  15                

cag act gta gcg ctt gct acg act gtt gca cca cat gtt gat att ctt         96
Gln Thr Val Ala Leu Ala Thr Thr Val Ala Pro His Val Asp Ile Leu           
            20                  25                  30                    

gaa atc ggt act cct tgt atc aag tac aac ggt atc aag ttg ctg gag        144
Glu Ile Gly Thr Pro Cys Ile Lys Tyr Asn Gly Ile Lys Leu Leu Glu           
        35                  40                  45                        

act ctc cgc gca aag ttc cct aac aac aag atc ctg gtt gac ctg aag        192
Thr Leu Arg Ala Lys Phe Pro Asn Asn Lys Ile Leu Val Asp Leu Lys           
    50                  55                  60                            

acc atg gat gct ggt ttt tac gaa gca gag cct ttc tac aag gca ggt        240
Thr Met Asp Ala Gly Phe Tyr Glu Ala Glu Pro Phe Tyr Lys Ala Gly           
65                  70                  75                  80            

gcc gac atc gtg acc gtg ctc ggc act gct gac att ggc acg atc aaa        288
Ala Asp Ile Val Thr Val Leu Gly Thr Ala Asp Ile Gly Thr Ile Lys           
                85                  90                  95                

ggc gtc att gat gtt gcc aac aaa tac ggc aag aag gct caa gtc gac        336
Gly Val Ile Asp Val Ala Asn Lys Tyr Gly Lys Lys Ala Gln Val Asp           
            100                 105                 110                   

ctg atc aac gtg act gac aag gct gca cgc acc aag gaa gtg gcc aag        384
Leu Ile Asn Val Thr Asp Lys Ala Ala Arg Thr Lys Glu Val Ala Lys           
        115                 120                 125                       

ctc ggc gct cac atc att ggc gtt cac act ggt ttg gat caa cag gct        432
Leu Gly Ala His Ile Ile Gly Val His Thr Gly Leu Asp Gln Gln Ala           
    130                 135                 140                           

gct ggt cag aca ccg ttt gcc gat ctc aac ctt gtt tcc agc ctg aac        480
Ala Gly Gln Thr Pro Phe Ala Asp Leu Asn Leu Val Ser Ser Leu Asn           
145                 150                 155                 160           

ctg ggt gtt gac att tcc gta gct ggt ggc gtg aag gcg act acc gcc        528
Leu Gly Val Asp Ile Ser Val Ala Gly Gly Val Lys Ala Thr Thr Ala           
                165                 170                 175               

aaa caa gtg gtt gat gca ggt gcc aca att gtt gtt gct ggt gcg gct        576
Lys Gln Val Val Asp Ala Gly Ala Thr Ile Val Val Ala Gly Ala Ala           
            180                 185                 190                   

atc tat ggt gct gcc gat cct gct gct gct gct gct gaa atc agc gct        624
Ile Tyr Gly Ala Ala Asp Pro Ala Ala Ala Ala Ala Glu Ile Ser Ala           
        195                 200                 205                       

gcg gcc aag ggt aca caa agc agt ggt ggc ctg ttt ggc tgg ctg aag        672
Ala Ala Lys Gly Thr Gln Ser Ser Gly Gly Leu Phe Gly Trp Leu Lys           
    210                 215                 220                           

aaa ctg ttc agc taa                                                    687
Lys Leu Phe Ser                                                           
225                                                                       


<210>  16
<211>  228
<212>  PRT
<213>  Methylobacillus flagellatus

<400>  16

Val Ala Lys Pro Leu Val Gln Met Ala Leu Asp Ser Leu Asp Phe Asp 
1               5                   10                  15      


Gln Thr Val Ala Leu Ala Thr Thr Val Ala Pro His Val Asp Ile Leu 
            20                  25                  30          


Glu Ile Gly Thr Pro Cys Ile Lys Tyr Asn Gly Ile Lys Leu Leu Glu 
        35                  40                  45              


Thr Leu Arg Ala Lys Phe Pro Asn Asn Lys Ile Leu Val Asp Leu Lys 
    50                  55                  60                  


Thr Met Asp Ala Gly Phe Tyr Glu Ala Glu Pro Phe Tyr Lys Ala Gly 
65                  70                  75                  80  


Ala Asp Ile Val Thr Val Leu Gly Thr Ala Asp Ile Gly Thr Ile Lys 
                85                  90                  95      


Gly Val Ile Asp Val Ala Asn Lys Tyr Gly Lys Lys Ala Gln Val Asp 
            100                 105                 110         


Leu Ile Asn Val Thr Asp Lys Ala Ala Arg Thr Lys Glu Val Ala Lys 
        115                 120                 125             


Leu Gly Ala His Ile Ile Gly Val His Thr Gly Leu Asp Gln Gln Ala 
    130                 135                 140                 


Ala Gly Gln Thr Pro Phe Ala Asp Leu Asn Leu Val Ser Ser Leu Asn 
145                 150                 155                 160 


Leu Gly Val Asp Ile Ser Val Ala Gly Gly Val Lys Ala Thr Thr Ala 
                165                 170                 175     


Lys Gln Val Val Asp Ala Gly Ala Thr Ile Val Val Ala Gly Ala Ala 
            180                 185                 190         


Ile Tyr Gly Ala Ala Asp Pro Ala Ala Ala Ala Ala Glu Ile Ser Ala 
        195                 200                 205             


Ala Ala Lys Gly Thr Gln Ser Ser Gly Gly Leu Phe Gly Trp Leu Lys 
    210                 215                 220                 


Lys Leu Phe Ser 
225             


<210>  17
<211>  2121
<212>  DNA
<213>  Candida boidinii


<220>
<221>  CDS
<222>  (1)..(2121)

<400>  17
atg gct ctc gca aaa gct gct tca att aac gat gat atc cat gat tta         48
Met Ala Leu Ala Lys Ala Ala Ser Ile Asn Asp Asp Ile His Asp Leu           
1               5                   10                  15                

aca atg aga gca ttc cgt tgt tat gtc ttg gat tta gtt gaa caa tat         96
Thr Met Arg Ala Phe Arg Cys Tyr Val Leu Asp Leu Val Glu Gln Tyr           
            20                  25                  30                    

gaa ggt ggt cat cct ggt tct gct atg ggt atg gtt gcc atg ggt att        144
Glu Gly Gly His Pro Gly Ser Ala Met Gly Met Val Ala Met Gly Ile           
        35                  40                  45                        

gca tta tgg aaa tat aca atg aaa tat tct aca aat gat cca aca tgg        192
Ala Leu Trp Lys Tyr Thr Met Lys Tyr Ser Thr Asn Asp Pro Thr Trp           
    50                  55                  60                            

ttc aat cgt gat aga ttt gtt tta tca aat ggt cat gtt tgt tta ttt        240
Phe Asn Arg Asp Arg Phe Val Leu Ser Asn Gly His Val Cys Leu Phe           
65                  70                  75                  80            

caa tat tta ttt caa cat tta tca ggt ttg aaa tct atg act gaa aag        288
Gln Tyr Leu Phe Gln His Leu Ser Gly Leu Lys Ser Met Thr Glu Lys           
                85                  90                  95                

caa tta aaa tct tat cat tca tca gat tac cat tct aaa tgt cct gga        336
Gln Leu Lys Ser Tyr His Ser Ser Asp Tyr His Ser Lys Cys Pro Gly           
            100                 105                 110                   

cat cca gaa att gaa aat gaa gct gtt gaa gtt act act ggt cca tta        384
His Pro Glu Ile Glu Asn Glu Ala Val Glu Val Thr Thr Gly Pro Leu           
        115                 120                 125                       

ggt caa ggt att tct aat tct gtt ggt tta gct att gca tct aaa aat        432
Gly Gln Gly Ile Ser Asn Ser Val Gly Leu Ala Ile Ala Ser Lys Asn           
    130                 135                 140                           

ttg ggt gca tta tat aac aag cca gga tat gaa gtt gtt aat aat act        480
Leu Gly Ala Leu Tyr Asn Lys Pro Gly Tyr Glu Val Val Asn Asn Thr           
145                 150                 155                 160           

aca tat tgt att gtt ggt gat gct tgt tta caa gaa ggt cca gca tta        528
Thr Tyr Cys Ile Val Gly Asp Ala Cys Leu Gln Glu Gly Pro Ala Leu           
                165                 170                 175               

gaa tct att tca ttt gca ggt cat tta gga tta gat aat tta gtt gtt        576
Glu Ser Ile Ser Phe Ala Gly His Leu Gly Leu Asp Asn Leu Val Val           
            180                 185                 190                   

att tat gat aac aat caa gtt tgt tgt gat ggt tct gtt gat att gct        624
Ile Tyr Asp Asn Asn Gln Val Cys Cys Asp Gly Ser Val Asp Ile Ala           
        195                 200                 205                       

aat act gaa gat att tca gct aag ttt aga gct tgt aat tgg aat gtt        672
Asn Thr Glu Asp Ile Ser Ala Lys Phe Arg Ala Cys Asn Trp Asn Val           
    210                 215                 220                           

att gaa gtt gaa gat ggt gct aga gat gtt gct act att gtc aag gca        720
Ile Glu Val Glu Asp Gly Ala Arg Asp Val Ala Thr Ile Val Lys Ala           
225                 230                 235                 240           

ttg gaa cta gct ggt gct gaa aag aat aga cca aca tta att aat gtt        768
Leu Glu Leu Ala Gly Ala Glu Lys Asn Arg Pro Thr Leu Ile Asn Val           
                245                 250                 255               

cgt act att att ggt act gat tca gct ttc caa aat cat tgt gct gct        816
Arg Thr Ile Ile Gly Thr Asp Ser Ala Phe Gln Asn His Cys Ala Ala           
            260                 265                 270                   

cat ggt agt gct tta ggt gaa gaa ggt att aga gaa ttg aaa atc aaa        864
His Gly Ser Ala Leu Gly Glu Glu Gly Ile Arg Glu Leu Lys Ile Lys           
        275                 280                 285                       

tat ggt ttt aat cca tct caa aaa ttc cat ttt cca caa gaa gtt tat        912
Tyr Gly Phe Asn Pro Ser Gln Lys Phe His Phe Pro Gln Glu Val Tyr           
    290                 295                 300                           

gat ttc ttt agt gat att cca gct aaa ggt gac gaa tat gtt tct aat        960
Asp Phe Phe Ser Asp Ile Pro Ala Lys Gly Asp Glu Tyr Val Ser Asn           
305                 310                 315                 320           

tgg aat aaa tta gtt agt agt tat gtt aaa gaa ttt cct gaa tta gga       1008
Trp Asn Lys Leu Val Ser Ser Tyr Val Lys Glu Phe Pro Glu Leu Gly           
                325                 330                 335               

gct gaa ttt caa tca aga gtt aaa ggt gaa tta cca aag aat tgg aaa       1056
Ala Glu Phe Gln Ser Arg Val Lys Gly Glu Leu Pro Lys Asn Trp Lys           
            340                 345                 350                   

tca tta tta cca aat aat tta cca aat gaa gat aca gca aca aga aca       1104
Ser Leu Leu Pro Asn Asn Leu Pro Asn Glu Asp Thr Ala Thr Arg Thr           
        355                 360                 365                       

tca gct aga gct atg gtt aga gca tta gct aaa gat gtt cca aat gtt       1152
Ser Ala Arg Ala Met Val Arg Ala Leu Ala Lys Asp Val Pro Asn Val           
    370                 375                 380                           

att gct ggt tca gca gat tta tca gtt tcg gtt aat tta cca tgg cct       1200
Ile Ala Gly Ser Ala Asp Leu Ser Val Ser Val Asn Leu Pro Trp Pro           
385                 390                 395                 400           

gga tct aaa tat ttt gaa aat cca caa tta gca aca caa tgt gga tta       1248
Gly Ser Lys Tyr Phe Glu Asn Pro Gln Leu Ala Thr Gln Cys Gly Leu           
                405                 410                 415               

gct ggt gat tat tct ggt aga tat gtt gaa ttt ggt att aga gaa cat       1296
Ala Gly Asp Tyr Ser Gly Arg Tyr Val Glu Phe Gly Ile Arg Glu His           
            420                 425                 430                   

tgt atg tgt gct att gct aat ggt tta gct gct ttt aac aaa ggt aca       1344
Cys Met Cys Ala Ile Ala Asn Gly Leu Ala Ala Phe Asn Lys Gly Thr           
        435                 440                 445                       

ttt tta cca att act tca tca ttt tat atg ttt tat ctc tat gca gcc       1392
Phe Leu Pro Ile Thr Ser Ser Phe Tyr Met Phe Tyr Leu Tyr Ala Ala           
    450                 455                 460                           

cca gca tta aga atg gct gca tta caa gaa tta aag gca att cat att       1440
Pro Ala Leu Arg Met Ala Ala Leu Gln Glu Leu Lys Ala Ile His Ile           
465                 470                 475                 480           

gct aca cat gat tct att ggt gct ggt gaa gat gga cca aca cat caa       1488
Ala Thr His Asp Ser Ile Gly Ala Gly Glu Asp Gly Pro Thr His Gln           
                485                 490                 495               

cct att gca caa tct gct tta tgg aga gca atg cct aat ttc tat tat       1536
Pro Ile Ala Gln Ser Ala Leu Trp Arg Ala Met Pro Asn Phe Tyr Tyr           
            500                 505                 510                   

atg aga cca ggt gat gct agt gaa gta cgt gga tta ttt gaa aaa gct       1584
Met Arg Pro Gly Asp Ala Ser Glu Val Arg Gly Leu Phe Glu Lys Ala           
        515                 520                 525                       

gtt gaa tta cca tta tct aca tta ttt tca tta tct aga cat gaa gtt       1632
Val Glu Leu Pro Leu Ser Thr Leu Phe Ser Leu Ser Arg His Glu Val           
    530                 535                 540                           

cca caa tat cca ggt aaa tca agt att gaa tta gct aaa aga ggt ggt       1680
Pro Gln Tyr Pro Gly Lys Ser Ser Ile Glu Leu Ala Lys Arg Gly Gly           
545                 550                 555                 560           

tat gta ttt gaa gat gct aaa gat gct gat att caa tta att ggt gct       1728
Tyr Val Phe Glu Asp Ala Lys Asp Ala Asp Ile Gln Leu Ile Gly Ala           
                565                 570                 575               

ggt tca gaa tta gaa caa gct gtt aaa act gct aga att tta aga tct       1776
Gly Ser Glu Leu Glu Gln Ala Val Lys Thr Ala Arg Ile Leu Arg Ser           
            580                 585                 590                   

aga gga tta aaa gtt cgt att tta tct ttc cca tgt caa cgt tta ttt       1824
Arg Gly Leu Lys Val Arg Ile Leu Ser Phe Pro Cys Gln Arg Leu Phe           
        595                 600                 605                       

gat gaa caa tct gtt gga tat aga aga tct gtt tta caa agg ggt aaa       1872
Asp Glu Gln Ser Val Gly Tyr Arg Arg Ser Val Leu Gln Arg Gly Lys           
    610                 615                 620                           

gtt cca act gtt gtt att gaa gct tat gtt gct tat ggt tgg gaa aga       1920
Val Pro Thr Val Val Ile Glu Ala Tyr Val Ala Tyr Gly Trp Glu Arg           
625                 630                 635                 640           

tat gct aca gca ggt tat act atg aat aca ttt ggt aaa tca tta cct       1968
Tyr Ala Thr Ala Gly Tyr Thr Met Asn Thr Phe Gly Lys Ser Leu Pro           
                645                 650                 655               

gtt gaa gat gtt tat gaa tat ttt ggt ttt aac cca tct gaa att tct       2016
Val Glu Asp Val Tyr Glu Tyr Phe Gly Phe Asn Pro Ser Glu Ile Ser           
            660                 665                 670                   

aaa aaa att gaa ggt tat gtt aga gca gtt aaa gct aat cct gat tta       2064
Lys Lys Ile Glu Gly Tyr Val Arg Ala Val Lys Ala Asn Pro Asp Leu           
        675                 680                 685                       

tta tat gaa ttt att gat tta acc gaa aaa cca aaa cat gat caa aat       2112
Leu Tyr Glu Phe Ile Asp Leu Thr Glu Lys Pro Lys His Asp Gln Asn           
    690                 695                 700                           

cat tta taa                                                           2121
His Leu                                                                   
705                                                                       


<210>  18
<211>  706
<212>  PRT
<213>  Candida boidinii

<400>  18

Met Ala Leu Ala Lys Ala Ala Ser Ile Asn Asp Asp Ile His Asp Leu 
1               5                   10                  15      


Thr Met Arg Ala Phe Arg Cys Tyr Val Leu Asp Leu Val Glu Gln Tyr 
            20                  25                  30          


Glu Gly Gly His Pro Gly Ser Ala Met Gly Met Val Ala Met Gly Ile 
        35                  40                  45              


Ala Leu Trp Lys Tyr Thr Met Lys Tyr Ser Thr Asn Asp Pro Thr Trp 
    50                  55                  60                  


Phe Asn Arg Asp Arg Phe Val Leu Ser Asn Gly His Val Cys Leu Phe 
65                  70                  75                  80  


Gln Tyr Leu Phe Gln His Leu Ser Gly Leu Lys Ser Met Thr Glu Lys 
                85                  90                  95      


Gln Leu Lys Ser Tyr His Ser Ser Asp Tyr His Ser Lys Cys Pro Gly 
            100                 105                 110         


His Pro Glu Ile Glu Asn Glu Ala Val Glu Val Thr Thr Gly Pro Leu 
        115                 120                 125             


Gly Gln Gly Ile Ser Asn Ser Val Gly Leu Ala Ile Ala Ser Lys Asn 
    130                 135                 140                 


Leu Gly Ala Leu Tyr Asn Lys Pro Gly Tyr Glu Val Val Asn Asn Thr 
145                 150                 155                 160 


Thr Tyr Cys Ile Val Gly Asp Ala Cys Leu Gln Glu Gly Pro Ala Leu 
                165                 170                 175     


Glu Ser Ile Ser Phe Ala Gly His Leu Gly Leu Asp Asn Leu Val Val 
            180                 185                 190         


Ile Tyr Asp Asn Asn Gln Val Cys Cys Asp Gly Ser Val Asp Ile Ala 
        195                 200                 205             


Asn Thr Glu Asp Ile Ser Ala Lys Phe Arg Ala Cys Asn Trp Asn Val 
    210                 215                 220                 


Ile Glu Val Glu Asp Gly Ala Arg Asp Val Ala Thr Ile Val Lys Ala 
225                 230                 235                 240 


Leu Glu Leu Ala Gly Ala Glu Lys Asn Arg Pro Thr Leu Ile Asn Val 
                245                 250                 255     


Arg Thr Ile Ile Gly Thr Asp Ser Ala Phe Gln Asn His Cys Ala Ala 
            260                 265                 270         


His Gly Ser Ala Leu Gly Glu Glu Gly Ile Arg Glu Leu Lys Ile Lys 
        275                 280                 285             


Tyr Gly Phe Asn Pro Ser Gln Lys Phe His Phe Pro Gln Glu Val Tyr 
    290                 295                 300                 


Asp Phe Phe Ser Asp Ile Pro Ala Lys Gly Asp Glu Tyr Val Ser Asn 
305                 310                 315                 320 


Trp Asn Lys Leu Val Ser Ser Tyr Val Lys Glu Phe Pro Glu Leu Gly 
                325                 330                 335     


Ala Glu Phe Gln Ser Arg Val Lys Gly Glu Leu Pro Lys Asn Trp Lys 
            340                 345                 350         


Ser Leu Leu Pro Asn Asn Leu Pro Asn Glu Asp Thr Ala Thr Arg Thr 
        355                 360                 365             


Ser Ala Arg Ala Met Val Arg Ala Leu Ala Lys Asp Val Pro Asn Val 
    370                 375                 380                 


Ile Ala Gly Ser Ala Asp Leu Ser Val Ser Val Asn Leu Pro Trp Pro 
385                 390                 395                 400 


Gly Ser Lys Tyr Phe Glu Asn Pro Gln Leu Ala Thr Gln Cys Gly Leu 
                405                 410                 415     


Ala Gly Asp Tyr Ser Gly Arg Tyr Val Glu Phe Gly Ile Arg Glu His 
            420                 425                 430         


Cys Met Cys Ala Ile Ala Asn Gly Leu Ala Ala Phe Asn Lys Gly Thr 
        435                 440                 445             


Phe Leu Pro Ile Thr Ser Ser Phe Tyr Met Phe Tyr Leu Tyr Ala Ala 
    450                 455                 460                 


Pro Ala Leu Arg Met Ala Ala Leu Gln Glu Leu Lys Ala Ile His Ile 
465                 470                 475                 480 


Ala Thr His Asp Ser Ile Gly Ala Gly Glu Asp Gly Pro Thr His Gln 
                485                 490                 495     


Pro Ile Ala Gln Ser Ala Leu Trp Arg Ala Met Pro Asn Phe Tyr Tyr 
            500                 505                 510         


Met Arg Pro Gly Asp Ala Ser Glu Val Arg Gly Leu Phe Glu Lys Ala 
        515                 520                 525             


Val Glu Leu Pro Leu Ser Thr Leu Phe Ser Leu Ser Arg His Glu Val 
    530                 535                 540                 


Pro Gln Tyr Pro Gly Lys Ser Ser Ile Glu Leu Ala Lys Arg Gly Gly 
545                 550                 555                 560 


Tyr Val Phe Glu Asp Ala Lys Asp Ala Asp Ile Gln Leu Ile Gly Ala 
                565                 570                 575     


Gly Ser Glu Leu Glu Gln Ala Val Lys Thr Ala Arg Ile Leu Arg Ser 
            580                 585                 590         


Arg Gly Leu Lys Val Arg Ile Leu Ser Phe Pro Cys Gln Arg Leu Phe 
        595                 600                 605             


Asp Glu Gln Ser Val Gly Tyr Arg Arg Ser Val Leu Gln Arg Gly Lys 
    610                 615                 620                 


Val Pro Thr Val Val Ile Glu Ala Tyr Val Ala Tyr Gly Trp Glu Arg 
625                 630                 635                 640 


Tyr Ala Thr Ala Gly Tyr Thr Met Asn Thr Phe Gly Lys Ser Leu Pro 
                645                 650                 655     


Val Glu Asp Val Tyr Glu Tyr Phe Gly Phe Asn Pro Ser Glu Ile Ser 
            660                 665                 670         


Lys Lys Ile Glu Gly Tyr Val Arg Ala Val Lys Ala Asn Pro Asp Leu 
        675                 680                 685             


Leu Tyr Glu Phe Ile Asp Leu Thr Glu Lys Pro Lys His Asp Gln Asn 
    690                 695                 700                 


His Leu 
705     


<210>  19
<211>  663
<212>  DNA
<213>  Salmonella enterica


<220>
<221>  CDS
<222>  (1)..(663)

<400>  19
atg gaa ctc tat ctg gat acc gct aac gtg gcg gaa gtt gaa cgt ctg         48
Met Glu Leu Tyr Leu Asp Thr Ala Asn Val Ala Glu Val Glu Arg Leu           
1               5                   10                  15                

gcg cgc att ttc ccg att gcc ggc gtc acc acc aat cca agc att gtg         96
Ala Arg Ile Phe Pro Ile Ala Gly Val Thr Thr Asn Pro Ser Ile Val           
            20                  25                  30                    

gca gcc agc aaa gaa tct atc tgg gat gtg ctg ccc agg ctg caa aac        144
Ala Ala Ser Lys Glu Ser Ile Trp Asp Val Leu Pro Arg Leu Gln Asn           
        35                  40                  45                        

gcc atc ggc gaa gaa ggc act tta ttt gcg cag acc atg agc cgc gac        192
Ala Ile Gly Glu Glu Gly Thr Leu Phe Ala Gln Thr Met Ser Arg Asp           
    50                  55                  60                            

gcg aaa ggg atg gtg gaa gaa gcc aaa cga ctg aat aac gcc atc ccc        240
Ala Lys Gly Met Val Glu Glu Ala Lys Arg Leu Asn Asn Ala Ile Pro           
65                  70                  75                  80            

ggc att gtg gtt aaa att ccg gtg acc gcc gaa ggt ctt gca gcg att        288
Gly Ile Val Val Lys Ile Pro Val Thr Ala Glu Gly Leu Ala Ala Ile           
                85                  90                  95                

aaa ttg ctg aaa aaa gaa ggc atc gtg acg ctg ggc acc gcc gtc tac        336
Lys Leu Leu Lys Lys Glu Gly Ile Val Thr Leu Gly Thr Ala Val Tyr           
            100                 105                 110                   

agc gca tcg cag ggc ctg ctg gcg gcg ctg gcg ggc gca aaa tat gtc        384
Ser Ala Ser Gln Gly Leu Leu Ala Ala Leu Ala Gly Ala Lys Tyr Val           
        115                 120                 125                       

gct ccc tac gtc aac cgc gtt gat gcg cag ggc ggc gat ggc att cgt        432
Ala Pro Tyr Val Asn Arg Val Asp Ala Gln Gly Gly Asp Gly Ile Arg           
    130                 135                 140                           

atg gtt cag gag ctg caa acg cta ctg gaa cat cac gcg ccc gac agc        480
Met Val Gln Glu Leu Gln Thr Leu Leu Glu His His Ala Pro Asp Ser           
145                 150                 155                 160           

atg gta ctg gcg gcc agc ttt aaa acg ccg cgg cag gcg ctg gat tgc        528
Met Val Leu Ala Ala Ser Phe Lys Thr Pro Arg Gln Ala Leu Asp Cys           
                165                 170                 175               

tta ctg gca ggt tgc cag gcg att acc ctt cct tta gat gta gcg caa        576
Leu Leu Ala Gly Cys Gln Ala Ile Thr Leu Pro Leu Asp Val Ala Gln           
            180                 185                 190                   

caa atg ctc aat acg cct gcg gta gag tcg gca ata gag aag ttt gag        624
Gln Met Leu Asn Thr Pro Ala Val Glu Ser Ala Ile Glu Lys Phe Glu           
        195                 200                 205                       

caa gac tgg aaa aac gct ttt ggt aat ctg aac ctg tag                    663
Gln Asp Trp Lys Asn Ala Phe Gly Asn Leu Asn Leu                           
    210                 215                 220                           


<210>  20
<211>  220
<212>  PRT
<213>  Salmonella enterica

<400>  20

Met Glu Leu Tyr Leu Asp Thr Ala Asn Val Ala Glu Val Glu Arg Leu 
1               5                   10                  15      


Ala Arg Ile Phe Pro Ile Ala Gly Val Thr Thr Asn Pro Ser Ile Val 
            20                  25                  30          


Ala Ala Ser Lys Glu Ser Ile Trp Asp Val Leu Pro Arg Leu Gln Asn 
        35                  40                  45              


Ala Ile Gly Glu Glu Gly Thr Leu Phe Ala Gln Thr Met Ser Arg Asp 
    50                  55                  60                  


Ala Lys Gly Met Val Glu Glu Ala Lys Arg Leu Asn Asn Ala Ile Pro 
65                  70                  75                  80  


Gly Ile Val Val Lys Ile Pro Val Thr Ala Glu Gly Leu Ala Ala Ile 
                85                  90                  95      


Lys Leu Leu Lys Lys Glu Gly Ile Val Thr Leu Gly Thr Ala Val Tyr 
            100                 105                 110         


Ser Ala Ser Gln Gly Leu Leu Ala Ala Leu Ala Gly Ala Lys Tyr Val 
        115                 120                 125             


Ala Pro Tyr Val Asn Arg Val Asp Ala Gln Gly Gly Asp Gly Ile Arg 
    130                 135                 140                 


Met Val Gln Glu Leu Gln Thr Leu Leu Glu His His Ala Pro Asp Ser 
145                 150                 155                 160 


Met Val Leu Ala Ala Ser Phe Lys Thr Pro Arg Gln Ala Leu Asp Cys 
                165                 170                 175     


Leu Leu Ala Gly Cys Gln Ala Ile Thr Leu Pro Leu Asp Val Ala Gln 
            180                 185                 190         


Gln Met Leu Asn Thr Pro Ala Val Glu Ser Ala Ile Glu Lys Phe Glu 
        195                 200                 205             


Gln Asp Trp Lys Asn Ala Phe Gly Asn Leu Asn Leu 
    210                 215                 220 


<210>  21
<211>  1992
<212>  DNA
<213>  Pichia pastoris


<220>
<221>  CDS
<222>  (1)..(1992)

<400>  21
atg gct atc ccc gaa gag ttt gat atc cta gtt cta ggt ggt gga tcc         48
Met Ala Ile Pro Glu Glu Phe Asp Ile Leu Val Leu Gly Gly Gly Ser           
1               5                   10                  15                

agt gga tcc tgt att gcc gga aga ttg gca aac ttg gac cac tcc ttg         96
Ser Gly Ser Cys Ile Ala Gly Arg Leu Ala Asn Leu Asp His Ser Leu           
            20                  25                  30                    

aaa gtt ggt ctt atc gaa gca ggt gag aac aac ctc aac aac cca tgg        144
Lys Val Gly Leu Ile Glu Ala Gly Glu Asn Asn Leu Asn Asn Pro Trp           
        35                  40                  45                        

gtc tac ctt cca ggt att tac cca aga aac atg aag ttg gac tcc aag        192
Val Tyr Leu Pro Gly Ile Tyr Pro Arg Asn Met Lys Leu Asp Ser Lys           
    50                  55                  60                            

act gct tcc ttc tac act tct aac cca tct cct cac ttg aat ggt aga        240
Thr Ala Ser Phe Tyr Thr Ser Asn Pro Ser Pro His Leu Asn Gly Arg           
65                  70                  75                  80            

aga gcc att gtt cca tgt gct aac gtc ttg ggt ggt ggt tct tct atc        288
Arg Ala Ile Val Pro Cys Ala Asn Val Leu Gly Gly Gly Ser Ser Ile           
                85                  90                  95                

aac ttc atg atg tac acc aga ggt tct gct tct gat tac gat gac ttc        336
Asn Phe Met Met Tyr Thr Arg Gly Ser Ala Ser Asp Tyr Asp Asp Phe           
            100                 105                 110                   

caa gcc gag ggc tgg aaa acc aag gac ttg ctt cca ttg atg aaa aag        384
Gln Ala Glu Gly Trp Lys Thr Lys Asp Leu Leu Pro Leu Met Lys Lys           
        115                 120                 125                       

act gag acc tac caa aga gct tgc aac aac cct gac att cac ggt ttc        432
Thr Glu Thr Tyr Gln Arg Ala Cys Asn Asn Pro Asp Ile His Gly Phe           
    130                 135                 140                           

gaa ggt cca atc aag gtt tct ttc ggt aac tac acc tac cca gtt tgc        480
Glu Gly Pro Ile Lys Val Ser Phe Gly Asn Tyr Thr Tyr Pro Val Cys           
145                 150                 155                 160           

cag gac ttc ttg agg gct tct gag tcc caa ggt att cca tac gtt gac        528
Gln Asp Phe Leu Arg Ala Ser Glu Ser Gln Gly Ile Pro Tyr Val Asp           
                165                 170                 175               

gac ttg gaa gac ttg gtt act gct cac ggt gct gaa cac tgg ttg aag        576
Asp Leu Glu Asp Leu Val Thr Ala His Gly Ala Glu His Trp Leu Lys           
            180                 185                 190                   

tgg atc aac aga gac act ggt cgt cgt tcc gac tct gct cat gca ttt        624
Trp Ile Asn Arg Asp Thr Gly Arg Arg Ser Asp Ser Ala His Ala Phe           
        195                 200                 205                       

gtc cac tct act atg aga aac cac gac aac ttg tac ttg atc tgt aac        672
Val His Ser Thr Met Arg Asn His Asp Asn Leu Tyr Leu Ile Cys Asn           
    210                 215                 220                           

acg aag gtc gac aaa att att gtc gaa gac gga aga gct gct gct gtt        720
Thr Lys Val Asp Lys Ile Ile Val Glu Asp Gly Arg Ala Ala Ala Val           
225                 230                 235                 240           

aga acc gtt cca agc aag cct ttg aac cca aag aag cca agt cac aag        768
Arg Thr Val Pro Ser Lys Pro Leu Asn Pro Lys Lys Pro Ser His Lys           
                245                 250                 255               

atc tac cgt gct aga aag caa atc gtt ttg tct tgt ggt acc atc tcc        816
Ile Tyr Arg Ala Arg Lys Gln Ile Val Leu Ser Cys Gly Thr Ile Ser           
            260                 265                 270                   

tct cca ttg gtt ttg caa aga tcc ggt ttt ggt gac cca atc aag ttg        864
Ser Pro Leu Val Leu Gln Arg Ser Gly Phe Gly Asp Pro Ile Lys Leu           
        275                 280                 285                       

aga gcc gct ggt gtt aag cct ttg gtc aac ttg cca ggt gtc gga aga        912
Arg Ala Ala Gly Val Lys Pro Leu Val Asn Leu Pro Gly Val Gly Arg           
    290                 295                 300                           

aac ttc caa gac cac tac tgt ttc ttc agt cct tac aga atc aag cct        960
Asn Phe Gln Asp His Tyr Cys Phe Phe Ser Pro Tyr Arg Ile Lys Pro           
305                 310                 315                 320           

cag tac gag tct ttc gat gac ttc gtc cgt ggt gat gct gag att caa       1008
Gln Tyr Glu Ser Phe Asp Asp Phe Val Arg Gly Asp Ala Glu Ile Gln           
                325                 330                 335               

aag aga gtc ttt gac caa tgg tac gcc aat ggt act ggt cct ctt gcc       1056
Lys Arg Val Phe Asp Gln Trp Tyr Ala Asn Gly Thr Gly Pro Leu Ala           
            340                 345                 350                   

act aac ggt atc gaa gct ggt gtc aag atc aga cca aca cca gaa gaa       1104
Thr Asn Gly Ile Glu Ala Gly Val Lys Ile Arg Pro Thr Pro Glu Glu           
        355                 360                 365                       

ctc tct caa atg gac gaa tcc ttc cag gag ggt tac aga gaa tac ttc       1152
Leu Ser Gln Met Asp Glu Ser Phe Gln Glu Gly Tyr Arg Glu Tyr Phe           
    370                 375                 380                           

gaa gac aag cca gac aag cca gtt atg cac tac tcc atc att gct ggt       1200
Glu Asp Lys Pro Asp Lys Pro Val Met His Tyr Ser Ile Ile Ala Gly           
385                 390                 395                 400           

ttc ttc ggt gac cac acc aag att cct cct gga aag tac atg act atg       1248
Phe Phe Gly Asp His Thr Lys Ile Pro Pro Gly Lys Tyr Met Thr Met           
                405                 410                 415               

ttc cac ttc ttg gaa tac cca ttc tcc aga ggt tcc att cac att acc       1296
Phe His Phe Leu Glu Tyr Pro Phe Ser Arg Gly Ser Ile His Ile Thr           
            420                 425                 430                   

tcc cca gac cca tac gca gct cca gac ttc gac cca ggt ttc atg aac       1344
Ser Pro Asp Pro Tyr Ala Ala Pro Asp Phe Asp Pro Gly Phe Met Asn           
        435                 440                 445                       

gat gaa aga gac atg gct cct atg gtt tgg gct tac aag aag tct aga       1392
Asp Glu Arg Asp Met Ala Pro Met Val Trp Ala Tyr Lys Lys Ser Arg           
    450                 455                 460                           

gaa acc gct aga aga atg gac cac ttt gcc ggt gag gtc act tct cac       1440
Glu Thr Ala Arg Arg Met Asp His Phe Ala Gly Glu Val Thr Ser His           
465                 470                 475                 480           

cac cct ctg ttc cca tac tca tcc gag gcc aga gcc ttg gaa atg gat       1488
His Pro Leu Phe Pro Tyr Ser Ser Glu Ala Arg Ala Leu Glu Met Asp           
                485                 490                 495               

ttg gag acc tct aat gcc tac ggt gga cct ttg aac ttg tct gct ggt       1536
Leu Glu Thr Ser Asn Ala Tyr Gly Gly Pro Leu Asn Leu Ser Ala Gly           
            500                 505                 510                   

ctt gct cac ggt tct tgg act caa cct ttg aag aag cca act gca aag       1584
Leu Ala His Gly Ser Trp Thr Gln Pro Leu Lys Lys Pro Thr Ala Lys           
        515                 520                 525                       

aac gaa ggc cac gtt act tcg aac cag gtc gag ctt cat cca gac atc       1632
Asn Glu Gly His Val Thr Ser Asn Gln Val Glu Leu His Pro Asp Ile           
    530                 535                 540                           

gag tac gat gag gag gat gac aag gcc att gag aac tac att cgt gag       1680
Glu Tyr Asp Glu Glu Asp Asp Lys Ala Ile Glu Asn Tyr Ile Arg Glu           
545                 550                 555                 560           

cac act gag acc aca tgg cac tgt ctg gga acc tgt tcc atc ggt cca       1728
His Thr Glu Thr Thr Trp His Cys Leu Gly Thr Cys Ser Ile Gly Pro           
                565                 570                 575               

aga gaa ggt tcc aag atc gtc aaa tgg ggt ggt gtt ttg gac cac aga       1776
Arg Glu Gly Ser Lys Ile Val Lys Trp Gly Gly Val Leu Asp His Arg           
            580                 585                 590                   

tcc aac gtt tac gga gtc aag ggc ttg aag gtt ggt gac ttg tcc gtg       1824
Ser Asn Val Tyr Gly Val Lys Gly Leu Lys Val Gly Asp Leu Ser Val           
        595                 600                 605                       

tgc cca gac aat gtt ggt tgt aac acc tac acc acc gct ctt ttg atc       1872
Cys Pro Asp Asn Val Gly Cys Asn Thr Tyr Thr Thr Ala Leu Leu Ile           
    610                 615                 620                           

ggt gaa aag act gcc act ttg gtt gga gaa gat tta gga tac tct ggt       1920
Gly Glu Lys Thr Ala Thr Leu Val Gly Glu Asp Leu Gly Tyr Ser Gly           
625                 630                 635                 640           

gag gcc tta gac atg act gtt cct cag ttc aag ttg ggc act tac gag       1968
Glu Ala Leu Asp Met Thr Val Pro Gln Phe Lys Leu Gly Thr Tyr Glu           
                645                 650                 655               

aag acc ggt ctt gct aga ttc taa                                       1992
Lys Thr Gly Leu Ala Arg Phe                                               
            660                                                           


<210>  22
<211>  663
<212>  PRT
<213>  Pichia pastoris

<400>  22

Met Ala Ile Pro Glu Glu Phe Asp Ile Leu Val Leu Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly Ser Cys Ile Ala Gly Arg Leu Ala Asn Leu Asp His Ser Leu 
            20                  25                  30          


Lys Val Gly Leu Ile Glu Ala Gly Glu Asn Asn Leu Asn Asn Pro Trp 
        35                  40                  45              


Val Tyr Leu Pro Gly Ile Tyr Pro Arg Asn Met Lys Leu Asp Ser Lys 
    50                  55                  60                  


Thr Ala Ser Phe Tyr Thr Ser Asn Pro Ser Pro His Leu Asn Gly Arg 
65                  70                  75                  80  


Arg Ala Ile Val Pro Cys Ala Asn Val Leu Gly Gly Gly Ser Ser Ile 
                85                  90                  95      


Asn Phe Met Met Tyr Thr Arg Gly Ser Ala Ser Asp Tyr Asp Asp Phe 
            100                 105                 110         


Gln Ala Glu Gly Trp Lys Thr Lys Asp Leu Leu Pro Leu Met Lys Lys 
        115                 120                 125             


Thr Glu Thr Tyr Gln Arg Ala Cys Asn Asn Pro Asp Ile His Gly Phe 
    130                 135                 140                 


Glu Gly Pro Ile Lys Val Ser Phe Gly Asn Tyr Thr Tyr Pro Val Cys 
145                 150                 155                 160 


Gln Asp Phe Leu Arg Ala Ser Glu Ser Gln Gly Ile Pro Tyr Val Asp 
                165                 170                 175     


Asp Leu Glu Asp Leu Val Thr Ala His Gly Ala Glu His Trp Leu Lys 
            180                 185                 190         


Trp Ile Asn Arg Asp Thr Gly Arg Arg Ser Asp Ser Ala His Ala Phe 
        195                 200                 205             


Val His Ser Thr Met Arg Asn His Asp Asn Leu Tyr Leu Ile Cys Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Ile Ile Val Glu Asp Gly Arg Ala Ala Ala Val 
225                 230                 235                 240 


Arg Thr Val Pro Ser Lys Pro Leu Asn Pro Lys Lys Pro Ser His Lys 
                245                 250                 255     


Ile Tyr Arg Ala Arg Lys Gln Ile Val Leu Ser Cys Gly Thr Ile Ser 
            260                 265                 270         


Ser Pro Leu Val Leu Gln Arg Ser Gly Phe Gly Asp Pro Ile Lys Leu 
        275                 280                 285             


Arg Ala Ala Gly Val Lys Pro Leu Val Asn Leu Pro Gly Val Gly Arg 
    290                 295                 300                 


Asn Phe Gln Asp His Tyr Cys Phe Phe Ser Pro Tyr Arg Ile Lys Pro 
305                 310                 315                 320 


Gln Tyr Glu Ser Phe Asp Asp Phe Val Arg Gly Asp Ala Glu Ile Gln 
                325                 330                 335     


Lys Arg Val Phe Asp Gln Trp Tyr Ala Asn Gly Thr Gly Pro Leu Ala 
            340                 345                 350         


Thr Asn Gly Ile Glu Ala Gly Val Lys Ile Arg Pro Thr Pro Glu Glu 
        355                 360                 365             


Leu Ser Gln Met Asp Glu Ser Phe Gln Glu Gly Tyr Arg Glu Tyr Phe 
    370                 375                 380                 


Glu Asp Lys Pro Asp Lys Pro Val Met His Tyr Ser Ile Ile Ala Gly 
385                 390                 395                 400 


Phe Phe Gly Asp His Thr Lys Ile Pro Pro Gly Lys Tyr Met Thr Met 
                405                 410                 415     


Phe His Phe Leu Glu Tyr Pro Phe Ser Arg Gly Ser Ile His Ile Thr 
            420                 425                 430         


Ser Pro Asp Pro Tyr Ala Ala Pro Asp Phe Asp Pro Gly Phe Met Asn 
        435                 440                 445             


Asp Glu Arg Asp Met Ala Pro Met Val Trp Ala Tyr Lys Lys Ser Arg 
    450                 455                 460                 


Glu Thr Ala Arg Arg Met Asp His Phe Ala Gly Glu Val Thr Ser His 
465                 470                 475                 480 


His Pro Leu Phe Pro Tyr Ser Ser Glu Ala Arg Ala Leu Glu Met Asp 
                485                 490                 495     


Leu Glu Thr Ser Asn Ala Tyr Gly Gly Pro Leu Asn Leu Ser Ala Gly 
            500                 505                 510         


Leu Ala His Gly Ser Trp Thr Gln Pro Leu Lys Lys Pro Thr Ala Lys 
        515                 520                 525             


Asn Glu Gly His Val Thr Ser Asn Gln Val Glu Leu His Pro Asp Ile 
    530                 535                 540                 


Glu Tyr Asp Glu Glu Asp Asp Lys Ala Ile Glu Asn Tyr Ile Arg Glu 
545                 550                 555                 560 


His Thr Glu Thr Thr Trp His Cys Leu Gly Thr Cys Ser Ile Gly Pro 
                565                 570                 575     


Arg Glu Gly Ser Lys Ile Val Lys Trp Gly Gly Val Leu Asp His Arg 
            580                 585                 590         


Ser Asn Val Tyr Gly Val Lys Gly Leu Lys Val Gly Asp Leu Ser Val 
        595                 600                 605             


Cys Pro Asp Asn Val Gly Cys Asn Thr Tyr Thr Thr Ala Leu Leu Ile 
    610                 615                 620                 


Gly Glu Lys Thr Ala Thr Leu Val Gly Glu Asp Leu Gly Tyr Ser Gly 
625                 630                 635                 640 


Glu Ala Leu Asp Met Thr Val Pro Gln Phe Lys Leu Gly Thr Tyr Glu 
                645                 650                 655     


Lys Thr Gly Leu Ala Arg Phe 
            660             


<210>  23
<211>  1185
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(1185)

<400>  23
atg aaa aat tgt gtc atc gtc agt gcg gta cgt act gct atc ggt agt         48
Met Lys Asn Cys Val Ile Val Ser Ala Val Arg Thr Ala Ile Gly Ser           
1               5                   10                  15                

ttt aac ggt tca ctc gct tcc acc agc gcc atc gac ctg ggg gcg aca         96
Phe Asn Gly Ser Leu Ala Ser Thr Ser Ala Ile Asp Leu Gly Ala Thr           
            20                  25                  30                    

gta att aaa gcc gcc att gaa cgt gca aaa atc gat tca caa cac gtt        144
Val Ile Lys Ala Ala Ile Glu Arg Ala Lys Ile Asp Ser Gln His Val           
        35                  40                  45                        

gat gaa gtg att atg ggt aac gtg tta caa gcc ggg ctg ggg caa aat        192
Asp Glu Val Ile Met Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn           
    50                  55                  60                            

ccg gcg cgt cag gca ctg tta aaa agc ggg ctg gca gaa acg gtg tgc        240
Pro Ala Arg Gln Ala Leu Leu Lys Ser Gly Leu Ala Glu Thr Val Cys           
65                  70                  75                  80            

gga ttc acg gtc aat aaa gta tgt ggt tcg ggt ctt aaa agt gtg gcg        288
Gly Phe Thr Val Asn Lys Val Cys Gly Ser Gly Leu Lys Ser Val Ala           
                85                  90                  95                

ctt gcc gcc cag gcc att cag gca ggt cag gcg cag agc att gtg gcg        336
Leu Ala Ala Gln Ala Ile Gln Ala Gly Gln Ala Gln Ser Ile Val Ala           
            100                 105                 110                   

ggg ggt atg gaa aat atg agt tta gcc ccc tac tta ctc gat gca aaa        384
Gly Gly Met Glu Asn Met Ser Leu Ala Pro Tyr Leu Leu Asp Ala Lys           
        115                 120                 125                       

gca cgc tct ggt tat cgt ctt gga gac gga cag gtt tat gac gta atc        432
Ala Arg Ser Gly Tyr Arg Leu Gly Asp Gly Gln Val Tyr Asp Val Ile           
    130                 135                 140                           

ctg cgc gat ggc ctg atg tgc gcc acc cat ggt tat cat atg ggg att        480
Leu Arg Asp Gly Leu Met Cys Ala Thr His Gly Tyr His Met Gly Ile           
145                 150                 155                 160           

acc gcc gaa aac gtg gct aaa gag tac gga att acc cgt gaa atg cag        528
Thr Ala Glu Asn Val Ala Lys Glu Tyr Gly Ile Thr Arg Glu Met Gln           
                165                 170                 175               

gat gaa ctg gcg cta cat tca cag cgt aaa gcg gca gcc gca att gag        576
Asp Glu Leu Ala Leu His Ser Gln Arg Lys Ala Ala Ala Ala Ile Glu           
            180                 185                 190                   

tcc ggt gct ttt aca gcc gaa atc gtc ccg gta aat gtt gtc act cga        624
Ser Gly Ala Phe Thr Ala Glu Ile Val Pro Val Asn Val Val Thr Arg           
        195                 200                 205                       

aag aaa acc ttc gtc ttc agt caa gac gaa ttc ccg aaa gcg aat tca        672
Lys Lys Thr Phe Val Phe Ser Gln Asp Glu Phe Pro Lys Ala Asn Ser           
    210                 215                 220                           

acg gct gaa gcg tta ggt gca ttg cgc ccg gcc ttc gat aaa gca gga        720
Thr Ala Glu Ala Leu Gly Ala Leu Arg Pro Ala Phe Asp Lys Ala Gly           
225                 230                 235                 240           

aca gtc acc gct ggg aac gcg tct ggt att aac gac ggt gct gcc gct        768
Thr Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Gly Ala Ala Ala           
                245                 250                 255               

ctg gtg att atg gaa gaa tct gcg gcg ctg gca gca ggc ctt acc ccc        816
Leu Val Ile Met Glu Glu Ser Ala Ala Leu Ala Ala Gly Leu Thr Pro           
            260                 265                 270                   

ctg gct cgc att aaa agt tat gcc agc ggt ggc gtg ccc ccc gca ttg        864
Leu Ala Arg Ile Lys Ser Tyr Ala Ser Gly Gly Val Pro Pro Ala Leu           
        275                 280                 285                       

atg ggt atg ggg cca gta cct gcc acg caa aaa gcg tta caa ctg gcg        912
Met Gly Met Gly Pro Val Pro Ala Thr Gln Lys Ala Leu Gln Leu Ala           
    290                 295                 300                           

ggg ctg caa ctg gcg gat att gat ctc att gag gct aat gaa gca ttt        960
Gly Leu Gln Leu Ala Asp Ile Asp Leu Ile Glu Ala Asn Glu Ala Phe           
305                 310                 315                 320           

gct gca cag ttc ctt gcc gtt ggg aaa aac ctg ggc ttt gat tct gag       1008
Ala Ala Gln Phe Leu Ala Val Gly Lys Asn Leu Gly Phe Asp Ser Glu           
                325                 330                 335               

aaa gtg aat gtc aac ggc ggg gcc atc gcg ctc ggg cat cct atc ggt       1056
Lys Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly           
            340                 345                 350                   

gcc agt ggt gct cgt att ctg gtc aca cta tta cat gcc atg cag gca       1104
Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu His Ala Met Gln Ala           
        355                 360                 365                       

cgc gat aaa acg ctg ggg ctg gca aca ctg tgc att ggc ggc ggt cag       1152
Arg Asp Lys Thr Leu Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln           
    370                 375                 380                           

gga att gcg atg gtg att gaa cgg ttg aat taa                           1185
Gly Ile Ala Met Val Ile Glu Arg Leu Asn                                   
385                 390                                                   


<210>  24
<211>  394
<212>  PRT
<213>  Escherichia coli

<400>  24

Met Lys Asn Cys Val Ile Val Ser Ala Val Arg Thr Ala Ile Gly Ser 
1               5                   10                  15      


Phe Asn Gly Ser Leu Ala Ser Thr Ser Ala Ile Asp Leu Gly Ala Thr 
            20                  25                  30          


Val Ile Lys Ala Ala Ile Glu Arg Ala Lys Ile Asp Ser Gln His Val 
        35                  40                  45              


Asp Glu Val Ile Met Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn 
    50                  55                  60                  


Pro Ala Arg Gln Ala Leu Leu Lys Ser Gly Leu Ala Glu Thr Val Cys 
65                  70                  75                  80  


Gly Phe Thr Val Asn Lys Val Cys Gly Ser Gly Leu Lys Ser Val Ala 
                85                  90                  95      


Leu Ala Ala Gln Ala Ile Gln Ala Gly Gln Ala Gln Ser Ile Val Ala 
            100                 105                 110         


Gly Gly Met Glu Asn Met Ser Leu Ala Pro Tyr Leu Leu Asp Ala Lys 
        115                 120                 125             


Ala Arg Ser Gly Tyr Arg Leu Gly Asp Gly Gln Val Tyr Asp Val Ile 
    130                 135                 140                 


Leu Arg Asp Gly Leu Met Cys Ala Thr His Gly Tyr His Met Gly Ile 
145                 150                 155                 160 


Thr Ala Glu Asn Val Ala Lys Glu Tyr Gly Ile Thr Arg Glu Met Gln 
                165                 170                 175     


Asp Glu Leu Ala Leu His Ser Gln Arg Lys Ala Ala Ala Ala Ile Glu 
            180                 185                 190         


Ser Gly Ala Phe Thr Ala Glu Ile Val Pro Val Asn Val Val Thr Arg 
        195                 200                 205             


Lys Lys Thr Phe Val Phe Ser Gln Asp Glu Phe Pro Lys Ala Asn Ser 
    210                 215                 220                 


Thr Ala Glu Ala Leu Gly Ala Leu Arg Pro Ala Phe Asp Lys Ala Gly 
225                 230                 235                 240 


Thr Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     


Leu Val Ile Met Glu Glu Ser Ala Ala Leu Ala Ala Gly Leu Thr Pro 
            260                 265                 270         


Leu Ala Arg Ile Lys Ser Tyr Ala Ser Gly Gly Val Pro Pro Ala Leu 
        275                 280                 285             


Met Gly Met Gly Pro Val Pro Ala Thr Gln Lys Ala Leu Gln Leu Ala 
    290                 295                 300                 


Gly Leu Gln Leu Ala Asp Ile Asp Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 


Ala Ala Gln Phe Leu Ala Val Gly Lys Asn Leu Gly Phe Asp Ser Glu 
                325                 330                 335     


Lys Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         


Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu His Ala Met Gln Ala 
        355                 360                 365             


Arg Asp Lys Thr Leu Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 


Gly Ile Ala Met Val Ile Glu Arg Leu Asn 
385                 390                 


<210>  25
<211>  1179
<212>  DNA
<213>  Clostridium acetobutylicum


<220>
<221>  CDS
<222>  (1)..(1179)

<400>  25
atg aaa gaa gtt gta ata gct agt gca gta aga aca gcg att gga tct         48
Met Lys Glu Val Val Ile Ala Ser Ala Val Arg Thr Ala Ile Gly Ser           
1               5                   10                  15                

tat gga aag tct ctt aag gat gta cca gca gta gat tta gga gct aca         96
Tyr Gly Lys Ser Leu Lys Asp Val Pro Ala Val Asp Leu Gly Ala Thr           
            20                  25                  30                    

gct ata aag gaa gca gtt aaa aaa gca gga ata aaa cca gag gat gtt        144
Ala Ile Lys Glu Ala Val Lys Lys Ala Gly Ile Lys Pro Glu Asp Val           
        35                  40                  45                        

aat gaa gtc att tta gga aat gtt ctt caa gca ggt tta gga cag aat        192
Asn Glu Val Ile Leu Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn           
    50                  55                  60                            

cca gca aga cag gca tct ttt aaa gca gga tta cca gtt gaa att cca        240
Pro Ala Arg Gln Ala Ser Phe Lys Ala Gly Leu Pro Val Glu Ile Pro           
65                  70                  75                  80            

gct atg act att aat aag gtt tgt ggt tca gga ctt aga aca gtt agc        288
Ala Met Thr Ile Asn Lys Val Cys Gly Ser Gly Leu Arg Thr Val Ser           
                85                  90                  95                

tta gca gca caa att ata aaa gca gga gat gct gac gta ata ata gca        336
Leu Ala Ala Gln Ile Ile Lys Ala Gly Asp Ala Asp Val Ile Ile Ala           
            100                 105                 110                   

ggt ggt atg gaa aat atg tct aga gct cct tac tta gcg aat aac gct        384
Gly Gly Met Glu Asn Met Ser Arg Ala Pro Tyr Leu Ala Asn Asn Ala           
        115                 120                 125                       

aga tgg gga tat aga atg gga aac gct aaa ttt gtt gat gaa atg atc        432
Arg Trp Gly Tyr Arg Met Gly Asn Ala Lys Phe Val Asp Glu Met Ile           
    130                 135                 140                           

act gac gga ttg tgg gat gca ttt aat gat tac cac atg gga ata aca        480
Thr Asp Gly Leu Trp Asp Ala Phe Asn Asp Tyr His Met Gly Ile Thr           
145                 150                 155                 160           

gca gaa aac ata gct gag aga tgg aac att tca aga gaa gaa caa gat        528
Ala Glu Asn Ile Ala Glu Arg Trp Asn Ile Ser Arg Glu Glu Gln Asp           
                165                 170                 175               

gag ttt gct ctt gca tca caa aaa aaa gct gaa gaa gct ata aaa tca        576
Glu Phe Ala Leu Ala Ser Gln Lys Lys Ala Glu Glu Ala Ile Lys Ser           
            180                 185                 190                   

ggt caa ttt aaa gat gaa ata gtt cct gta gta att aaa ggc aga aag        624
Gly Gln Phe Lys Asp Glu Ile Val Pro Val Val Ile Lys Gly Arg Lys           
        195                 200                 205                       

gga gaa act gta gtt gat aca gat gag cac cct aga ttt gga tca act        672
Gly Glu Thr Val Val Asp Thr Asp Glu His Pro Arg Phe Gly Ser Thr           
    210                 215                 220                           

ata gaa gga ctt gca aaa tta aaa cct gcc ttc aaa aaa gat gga aca        720
Ile Glu Gly Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Thr           
225                 230                 235                 240           

gtt aca gct ggt aat gca tca gga tta aat gac tgt gca gca gta ctt        768
Val Thr Ala Gly Asn Ala Ser Gly Leu Asn Asp Cys Ala Ala Val Leu           
                245                 250                 255               

gta atc atg agt gca gaa aaa gct aaa gag ctt gga gta aaa cca ctt        816
Val Ile Met Ser Ala Glu Lys Ala Lys Glu Leu Gly Val Lys Pro Leu           
            260                 265                 270                   

gct aag ata gtt tct tat ggt tca gca gga gtt gac cca gca ata atg        864
Ala Lys Ile Val Ser Tyr Gly Ser Ala Gly Val Asp Pro Ala Ile Met           
        275                 280                 285                       

gga tat gga cct ttc tat gca aca aaa gca gct att gaa aaa gca ggt        912
Gly Tyr Gly Pro Phe Tyr Ala Thr Lys Ala Ala Ile Glu Lys Ala Gly           
    290                 295                 300                           

tgg aca gtt gat gaa tta gat tta ata gaa tca aat gaa gct ttt gca        960
Trp Thr Val Asp Glu Leu Asp Leu Ile Glu Ser Asn Glu Ala Phe Ala           
305                 310                 315                 320           

gct caa agt tta gca gta gca aaa gat tta aaa ttt gat atg aat aaa       1008
Ala Gln Ser Leu Ala Val Ala Lys Asp Leu Lys Phe Asp Met Asn Lys           
                325                 330                 335               

gta aat gta aat gga gga gct att gcc ctt ggt cat cca att gga gca       1056
Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly Ala           
            340                 345                 350                   

tca ggt gca aga ata ctc gtt act ctt gta cac gca atg caa aaa aga       1104
Ser Gly Ala Arg Ile Leu Val Thr Leu Val His Ala Met Gln Lys Arg           
        355                 360                 365                       

gat gca aaa aaa ggc tta gca act tta tgt ata ggt ggc gga caa gga       1152
Asp Ala Lys Lys Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln Gly           
    370                 375                 380                           

aca gca ata ttg cta gaa aag tgc tag                                   1179
Thr Ala Ile Leu Leu Glu Lys Cys                                           
385                 390                                                   


<210>  26
<211>  392
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  26

Met Lys Glu Val Val Ile Ala Ser Ala Val Arg Thr Ala Ile Gly Ser 
1               5                   10                  15      


Tyr Gly Lys Ser Leu Lys Asp Val Pro Ala Val Asp Leu Gly Ala Thr 
            20                  25                  30          


Ala Ile Lys Glu Ala Val Lys Lys Ala Gly Ile Lys Pro Glu Asp Val 
        35                  40                  45              


Asn Glu Val Ile Leu Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn 
    50                  55                  60                  


Pro Ala Arg Gln Ala Ser Phe Lys Ala Gly Leu Pro Val Glu Ile Pro 
65                  70                  75                  80  


Ala Met Thr Ile Asn Lys Val Cys Gly Ser Gly Leu Arg Thr Val Ser 
                85                  90                  95      


Leu Ala Ala Gln Ile Ile Lys Ala Gly Asp Ala Asp Val Ile Ile Ala 
            100                 105                 110         


Gly Gly Met Glu Asn Met Ser Arg Ala Pro Tyr Leu Ala Asn Asn Ala 
        115                 120                 125             


Arg Trp Gly Tyr Arg Met Gly Asn Ala Lys Phe Val Asp Glu Met Ile 
    130                 135                 140                 


Thr Asp Gly Leu Trp Asp Ala Phe Asn Asp Tyr His Met Gly Ile Thr 
145                 150                 155                 160 


Ala Glu Asn Ile Ala Glu Arg Trp Asn Ile Ser Arg Glu Glu Gln Asp 
                165                 170                 175     


Glu Phe Ala Leu Ala Ser Gln Lys Lys Ala Glu Glu Ala Ile Lys Ser 
            180                 185                 190         


Gly Gln Phe Lys Asp Glu Ile Val Pro Val Val Ile Lys Gly Arg Lys 
        195                 200                 205             


Gly Glu Thr Val Val Asp Thr Asp Glu His Pro Arg Phe Gly Ser Thr 
    210                 215                 220                 


Ile Glu Gly Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Thr 
225                 230                 235                 240 


Val Thr Ala Gly Asn Ala Ser Gly Leu Asn Asp Cys Ala Ala Val Leu 
                245                 250                 255     


Val Ile Met Ser Ala Glu Lys Ala Lys Glu Leu Gly Val Lys Pro Leu 
            260                 265                 270         


Ala Lys Ile Val Ser Tyr Gly Ser Ala Gly Val Asp Pro Ala Ile Met 
        275                 280                 285             


Gly Tyr Gly Pro Phe Tyr Ala Thr Lys Ala Ala Ile Glu Lys Ala Gly 
    290                 295                 300                 


Trp Thr Val Asp Glu Leu Asp Leu Ile Glu Ser Asn Glu Ala Phe Ala 
305                 310                 315                 320 


Ala Gln Ser Leu Ala Val Ala Lys Asp Leu Lys Phe Asp Met Asn Lys 
                325                 330                 335     


Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly Ala 
            340                 345                 350         


Ser Gly Ala Arg Ile Leu Val Thr Leu Val His Ala Met Gln Lys Arg 
        355                 360                 365             


Asp Ala Lys Lys Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln Gly 
    370                 375                 380                 


Thr Ala Ile Leu Leu Glu Lys Cys 
385                 390         


<210>  27
<211>  849
<212>  DNA
<213>  Clostridium acetobutylicum


<220>
<221>  CDS
<222>  (1)..(849)

<400>  27
atg aaa aag gta tgt gtt ata ggt gca ggt act atg ggt tca gga att         48
Met Lys Lys Val Cys Val Ile Gly Ala Gly Thr Met Gly Ser Gly Ile           
1               5                   10                  15                

gct cag gca ttt gca gct aaa gga ttt gaa gta gta tta aga gat att         96
Ala Gln Ala Phe Ala Ala Lys Gly Phe Glu Val Val Leu Arg Asp Ile           
            20                  25                  30                    

aaa gat gaa ttt gtt gat aga gga tta gat ttt atc aat aaa aat ctt        144
Lys Asp Glu Phe Val Asp Arg Gly Leu Asp Phe Ile Asn Lys Asn Leu           
        35                  40                  45                        

tct aaa tta gtt aaa aaa gga aag ata gaa gaa gct act aaa gtt gaa        192
Ser Lys Leu Val Lys Lys Gly Lys Ile Glu Glu Ala Thr Lys Val Glu           
    50                  55                  60                            

atc tta act aga att tcc gga aca gtt gac ctt aat atg gca gct gat        240
Ile Leu Thr Arg Ile Ser Gly Thr Val Asp Leu Asn Met Ala Ala Asp           
65                  70                  75                  80            

tgc gat tta gtt ata gaa gca gct gtt gaa aga atg gat att aaa aag        288
Cys Asp Leu Val Ile Glu Ala Ala Val Glu Arg Met Asp Ile Lys Lys           
                85                  90                  95                

cag att ttt gct gac tta gac aat ata tgc aag cca gaa aca att ctt        336
Gln Ile Phe Ala Asp Leu Asp Asn Ile Cys Lys Pro Glu Thr Ile Leu           
            100                 105                 110                   

gca tca aat aca tca tca ctt tca ata aca gaa gtg gca tca gca act        384
Ala Ser Asn Thr Ser Ser Leu Ser Ile Thr Glu Val Ala Ser Ala Thr           
        115                 120                 125                       

aaa aga cct gat aag gtt ata ggt atg cat ttc ttt aat cca gct cct        432
Lys Arg Pro Asp Lys Val Ile Gly Met His Phe Phe Asn Pro Ala Pro           
    130                 135                 140                           

gtt atg aag ctt gta gag gta ata aga gga ata gct aca tca caa gaa        480
Val Met Lys Leu Val Glu Val Ile Arg Gly Ile Ala Thr Ser Gln Glu           
145                 150                 155                 160           

act ttt gat gca gtt aaa gag aca tct ata gca ata gga aaa gat cct        528
Thr Phe Asp Ala Val Lys Glu Thr Ser Ile Ala Ile Gly Lys Asp Pro           
                165                 170                 175               

gta gaa gta gca gaa gca cca gga ttt gtt gta aat aga ata tta ata        576
Val Glu Val Ala Glu Ala Pro Gly Phe Val Val Asn Arg Ile Leu Ile           
            180                 185                 190                   

cca atg att aat gaa gca gtt ggt ata tta gca gaa gga ata gct tca        624
Pro Met Ile Asn Glu Ala Val Gly Ile Leu Ala Glu Gly Ile Ala Ser           
        195                 200                 205                       

gta gaa gac ata gat aaa gct atg aaa ctt gga gct aat cac cca atg        672
Val Glu Asp Ile Asp Lys Ala Met Lys Leu Gly Ala Asn His Pro Met           
    210                 215                 220                           

gga cca tta gaa tta ggt gat ttt ata ggt ctt gat ata tgt ctt gct        720
Gly Pro Leu Glu Leu Gly Asp Phe Ile Gly Leu Asp Ile Cys Leu Ala           
225                 230                 235                 240           

ata atg gat gtt tta tac tca gaa act gga gat tct aag tat aga cca        768
Ile Met Asp Val Leu Tyr Ser Glu Thr Gly Asp Ser Lys Tyr Arg Pro           
                245                 250                 255               

cat aca tta ctt aag aag tat gta aga gca gga tgg ctt gga aga aaa        816
His Thr Leu Leu Lys Lys Tyr Val Arg Ala Gly Trp Leu Gly Arg Lys           
            260                 265                 270                   

tca gga aaa ggt ttc tac gat tat tca aaa taa                            849
Ser Gly Lys Gly Phe Tyr Asp Tyr Ser Lys                                   
        275                 280                                           


<210>  28
<211>  282
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  28

Met Lys Lys Val Cys Val Ile Gly Ala Gly Thr Met Gly Ser Gly Ile 
1               5                   10                  15      


Ala Gln Ala Phe Ala Ala Lys Gly Phe Glu Val Val Leu Arg Asp Ile 
            20                  25                  30          


Lys Asp Glu Phe Val Asp Arg Gly Leu Asp Phe Ile Asn Lys Asn Leu 
        35                  40                  45              


Ser Lys Leu Val Lys Lys Gly Lys Ile Glu Glu Ala Thr Lys Val Glu 
    50                  55                  60                  


Ile Leu Thr Arg Ile Ser Gly Thr Val Asp Leu Asn Met Ala Ala Asp 
65                  70                  75                  80  


Cys Asp Leu Val Ile Glu Ala Ala Val Glu Arg Met Asp Ile Lys Lys 
                85                  90                  95      


Gln Ile Phe Ala Asp Leu Asp Asn Ile Cys Lys Pro Glu Thr Ile Leu 
            100                 105                 110         


Ala Ser Asn Thr Ser Ser Leu Ser Ile Thr Glu Val Ala Ser Ala Thr 
        115                 120                 125             


Lys Arg Pro Asp Lys Val Ile Gly Met His Phe Phe Asn Pro Ala Pro 
    130                 135                 140                 


Val Met Lys Leu Val Glu Val Ile Arg Gly Ile Ala Thr Ser Gln Glu 
145                 150                 155                 160 


Thr Phe Asp Ala Val Lys Glu Thr Ser Ile Ala Ile Gly Lys Asp Pro 
                165                 170                 175     


Val Glu Val Ala Glu Ala Pro Gly Phe Val Val Asn Arg Ile Leu Ile 
            180                 185                 190         


Pro Met Ile Asn Glu Ala Val Gly Ile Leu Ala Glu Gly Ile Ala Ser 
        195                 200                 205             


Val Glu Asp Ile Asp Lys Ala Met Lys Leu Gly Ala Asn His Pro Met 
    210                 215                 220                 


Gly Pro Leu Glu Leu Gly Asp Phe Ile Gly Leu Asp Ile Cys Leu Ala 
225                 230                 235                 240 


Ile Met Asp Val Leu Tyr Ser Glu Thr Gly Asp Ser Lys Tyr Arg Pro 
                245                 250                 255     


His Thr Leu Leu Lys Lys Tyr Val Arg Ala Gly Trp Leu Gly Arg Lys 
            260                 265                 270         


Ser Gly Lys Gly Phe Tyr Asp Tyr Ser Lys 
        275                 280         


<210>  29
<211>  786
<212>  DNA
<213>  Clostridium acetobutylicum


<220>
<221>  CDS
<222>  (1)..(786)

<400>  29
atg gaa cta aac aat gtc atc ctt gaa aag gaa ggt aaa gtt gct gta         48
Met Glu Leu Asn Asn Val Ile Leu Glu Lys Glu Gly Lys Val Ala Val           
1               5                   10                  15                

gtt acc att aac aga cct aaa gca tta aat gcg tta aat agt gat aca         96
Val Thr Ile Asn Arg Pro Lys Ala Leu Asn Ala Leu Asn Ser Asp Thr           
            20                  25                  30                    

cta aaa gaa atg gat tat gtt ata ggt gaa att gaa aat gat agc gaa        144
Leu Lys Glu Met Asp Tyr Val Ile Gly Glu Ile Glu Asn Asp Ser Glu           
        35                  40                  45                        

gta ctt gca gta att tta act gga gca gga gaa aaa tca ttt gta gca        192
Val Leu Ala Val Ile Leu Thr Gly Ala Gly Glu Lys Ser Phe Val Ala           
    50                  55                  60                            

gga gca gat att tct gag atg aag gaa atg aat acc att gaa ggt aga        240
Gly Ala Asp Ile Ser Glu Met Lys Glu Met Asn Thr Ile Glu Gly Arg           
65                  70                  75                  80            

aaa ttc ggg ata ctt gga aat aaa gtg ttt aga aga tta gaa ctt ctt        288
Lys Phe Gly Ile Leu Gly Asn Lys Val Phe Arg Arg Leu Glu Leu Leu           
                85                  90                  95                

gaa aag cct gta ata gca gct gtt aat ggt ttt gct tta gga ggc gga        336
Glu Lys Pro Val Ile Ala Ala Val Asn Gly Phe Ala Leu Gly Gly Gly           
            100                 105                 110                   

tgc gaa ata gct atg tct tgt gat ata aga ata gct tca agc aac gca        384
Cys Glu Ile Ala Met Ser Cys Asp Ile Arg Ile Ala Ser Ser Asn Ala           
        115                 120                 125                       

aga ttt ggt caa cca gaa gta ggt ctc gga ata aca cct ggt ttt ggt        432
Arg Phe Gly Gln Pro Glu Val Gly Leu Gly Ile Thr Pro Gly Phe Gly           
    130                 135                 140                           

ggt aca caa aga ctt tca aga tta gtt gga atg ggc atg gca aag cag        480
Gly Thr Gln Arg Leu Ser Arg Leu Val Gly Met Gly Met Ala Lys Gln           
145                 150                 155                 160           

ctt ata ttt act gca caa aat ata aag gca gat gaa gca tta aga atc        528
Leu Ile Phe Thr Ala Gln Asn Ile Lys Ala Asp Glu Ala Leu Arg Ile           
                165                 170                 175               

gga ctt gta aat aag gta gta gaa cct agt gaa tta atg aat aca gca        576
Gly Leu Val Asn Lys Val Val Glu Pro Ser Glu Leu Met Asn Thr Ala           
            180                 185                 190                   

aaa gaa att gca aac aaa att gtg agc aat gct cca gta gct gtt aag        624
Lys Glu Ile Ala Asn Lys Ile Val Ser Asn Ala Pro Val Ala Val Lys           
        195                 200                 205                       

tta agc aaa cag gct att aat aga gga atg cag tgt gat att gat act        672
Leu Ser Lys Gln Ala Ile Asn Arg Gly Met Gln Cys Asp Ile Asp Thr           
    210                 215                 220                           

gct tta gca ttt gaa tca gaa gca ttt gga gaa tgc ttt tca aca gag        720
Ala Leu Ala Phe Glu Ser Glu Ala Phe Gly Glu Cys Phe Ser Thr Glu           
225                 230                 235                 240           

gat caa aag gat gca atg aca gct ttc ata gag aaa aga aaa att gaa        768
Asp Gln Lys Asp Ala Met Thr Ala Phe Ile Glu Lys Arg Lys Ile Glu           
                245                 250                 255               

ggc ttc aaa aat aga tag                                                786
Gly Phe Lys Asn Arg                                                       
            260                                                           


<210>  30
<211>  261
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  30

Met Glu Leu Asn Asn Val Ile Leu Glu Lys Glu Gly Lys Val Ala Val 
1               5                   10                  15      


Val Thr Ile Asn Arg Pro Lys Ala Leu Asn Ala Leu Asn Ser Asp Thr 
            20                  25                  30          


Leu Lys Glu Met Asp Tyr Val Ile Gly Glu Ile Glu Asn Asp Ser Glu 
        35                  40                  45              


Val Leu Ala Val Ile Leu Thr Gly Ala Gly Glu Lys Ser Phe Val Ala 
    50                  55                  60                  


Gly Ala Asp Ile Ser Glu Met Lys Glu Met Asn Thr Ile Glu Gly Arg 
65                  70                  75                  80  


Lys Phe Gly Ile Leu Gly Asn Lys Val Phe Arg Arg Leu Glu Leu Leu 
                85                  90                  95      


Glu Lys Pro Val Ile Ala Ala Val Asn Gly Phe Ala Leu Gly Gly Gly 
            100                 105                 110         


Cys Glu Ile Ala Met Ser Cys Asp Ile Arg Ile Ala Ser Ser Asn Ala 
        115                 120                 125             


Arg Phe Gly Gln Pro Glu Val Gly Leu Gly Ile Thr Pro Gly Phe Gly 
    130                 135                 140                 


Gly Thr Gln Arg Leu Ser Arg Leu Val Gly Met Gly Met Ala Lys Gln 
145                 150                 155                 160 


Leu Ile Phe Thr Ala Gln Asn Ile Lys Ala Asp Glu Ala Leu Arg Ile 
                165                 170                 175     


Gly Leu Val Asn Lys Val Val Glu Pro Ser Glu Leu Met Asn Thr Ala 
            180                 185                 190         


Lys Glu Ile Ala Asn Lys Ile Val Ser Asn Ala Pro Val Ala Val Lys 
        195                 200                 205             


Leu Ser Lys Gln Ala Ile Asn Arg Gly Met Gln Cys Asp Ile Asp Thr 
    210                 215                 220                 


Ala Leu Ala Phe Glu Ser Glu Ala Phe Gly Glu Cys Phe Ser Thr Glu 
225                 230                 235                 240 


Asp Gln Lys Asp Ala Met Thr Ala Phe Ile Glu Lys Arg Lys Ile Glu 
                245                 250                 255     


Gly Phe Lys Asn Arg 
            260     


<210>  31
<211>  1344
<212>  DNA
<213>  Streptomyces coelicolor


<220>
<221>  CDS
<222>  (1)..(1344)

<400>  31
gtg acc gtg aag gac atc ctg gac gcg atc cag tcg ccc gac tcc acg         48
Val Thr Val Lys Asp Ile Leu Asp Ala Ile Gln Ser Pro Asp Ser Thr           
1               5                   10                  15                

ccg gcc gac atc gcc gca ctg ccg ctc ccc gag tcg tac cgc gcg atc         96
Pro Ala Asp Ile Ala Ala Leu Pro Leu Pro Glu Ser Tyr Arg Ala Ile           
            20                  25                  30                    

acc gtg cac aag gac gag acc gag atg ttc gcg ggc ctc gag acc cgc        144
Thr Val His Lys Asp Glu Thr Glu Met Phe Ala Gly Leu Glu Thr Arg           
        35                  40                  45                        

gac aag gac ccc cgc aag tcg atc cac ctg gac gac gtg ccg gtg ccc        192
Asp Lys Asp Pro Arg Lys Ser Ile His Leu Asp Asp Val Pro Val Pro           
    50                  55                  60                            

gag ctg ggc ccc ggc gag gcc ctg gtg gcc gtc atg gcc tcc tcg gtc        240
Glu Leu Gly Pro Gly Glu Ala Leu Val Ala Val Met Ala Ser Ser Val           
65                  70                  75                  80            

aac tac aac tcg gtg tgg acc tcg atc ttc gag ccg ctg tcc acc ttc        288
Asn Tyr Asn Ser Val Trp Thr Ser Ile Phe Glu Pro Leu Ser Thr Phe           
                85                  90                  95                

ggg ttc ctg gag cgc tac ggc cgg gtc agc gac ctc gcc aag cgg cac        336
Gly Phe Leu Glu Arg Tyr Gly Arg Val Ser Asp Leu Ala Lys Arg His           
            100                 105                 110                   

gac ctg ccg tac cac gtc atc ggc tcc gac ctc gcc ggt gtc gtc ctg        384
Asp Leu Pro Tyr His Val Ile Gly Ser Asp Leu Ala Gly Val Val Leu           
        115                 120                 125                       

cgc acc ggt ccg ggc gtc aac gcc tgg cag gcg ggc gac gag gtc gtc        432
Arg Thr Gly Pro Gly Val Asn Ala Trp Gln Ala Gly Asp Glu Val Val           
    130                 135                 140                           

gcg cac tgc ctc tcc gtc gag ctg gag tcc tcc gac ggc cac aac gac        480
Ala His Cys Leu Ser Val Glu Leu Glu Ser Ser Asp Gly His Asn Asp           
145                 150                 155                 160           

acg atg ctc gac ccc gag cag cgc atc tgg ggc ttc gag acc aac ttc        528
Thr Met Leu Asp Pro Glu Gln Arg Ile Trp Gly Phe Glu Thr Asn Phe           
                165                 170                 175               

ggc ggc ctc gcg gag atc gcg ctg gtc aag tcc aac cag ctg atg ccg        576
Gly Gly Leu Ala Glu Ile Ala Leu Val Lys Ser Asn Gln Leu Met Pro           
            180                 185                 190                   

aag ccg gac cac ctg agc tgg gag gag gcc gcc gct ccc ggc ctg gtc        624
Lys Pro Asp His Leu Ser Trp Glu Glu Ala Ala Ala Pro Gly Leu Val           
        195                 200                 205                       

aac tcc acc gcg tac cgc cag ctc gtc tcc cgc aac ggc gcc ggc atg        672
Asn Ser Thr Ala Tyr Arg Gln Leu Val Ser Arg Asn Gly Ala Gly Met           
    210                 215                 220                           

aag cag ggc gac aac gtg ctc atc tgg ggc gcg agc ggc gga ctc ggc        720
Lys Gln Gly Asp Asn Val Leu Ile Trp Gly Ala Ser Gly Gly Leu Gly           
225                 230                 235                 240           

tcg tac gcc acc cag ttc gcc ctc gcc ggc ggc gcc aac ccg atc tgc        768
Ser Tyr Ala Thr Gln Phe Ala Leu Ala Gly Gly Ala Asn Pro Ile Cys           
                245                 250                 255               

gtc gtc tcc tcg ccg cag aag gcg gag atc tgc cgc gcg atg ggc gcc        816
Val Val Ser Ser Pro Gln Lys Ala Glu Ile Cys Arg Ala Met Gly Ala           
            260                 265                 270                   

gag gcg atc atc gac cgc aac gcc gag ggc tac cgg ttc tgg aag gac        864
Glu Ala Ile Ile Asp Arg Asn Ala Glu Gly Tyr Arg Phe Trp Lys Asp           
        275                 280                 285                       

gag aac acc cag gac ccg aag gag tgg aag cgc ttc ggc aag cgc atc        912
Glu Asn Thr Gln Asp Pro Lys Glu Trp Lys Arg Phe Gly Lys Arg Ile           
    290                 295                 300                           

cgc gaa ctg acc ggc ggc gag gac atc gac atc gtc ttc gag cac ccc        960
Arg Glu Leu Thr Gly Gly Glu Asp Ile Asp Ile Val Phe Glu His Pro           
305                 310                 315                 320           

ggc cgc gag acc ttc ggc gcc tcc gtc ttc gtc acc cgc aag ggc ggc       1008
Gly Arg Glu Thr Phe Gly Ala Ser Val Phe Val Thr Arg Lys Gly Gly           
                325                 330                 335               

acc atc acc acc tgc gcc tcg acc tcg ggc tac atg cac gag tac gac       1056
Thr Ile Thr Thr Cys Ala Ser Thr Ser Gly Tyr Met His Glu Tyr Asp           
            340                 345                 350                   

aac cgc tac ctg tgg atg tcc ctg aag cgc atc atc ggc tcg cac ttc       1104
Asn Arg Tyr Leu Trp Met Ser Leu Lys Arg Ile Ile Gly Ser His Phe           
        355                 360                 365                       

gcc aac tac cgc gag gcc tgg gag gcc aac cgc ctc atc gcc aag ggc       1152
Ala Asn Tyr Arg Glu Ala Trp Glu Ala Asn Arg Leu Ile Ala Lys Gly           
    370                 375                 380                           

agg atc cac ccc acg ctc tcc aag gtg tac tcc ctc gag gac acc ggc       1200
Arg Ile His Pro Thr Leu Ser Lys Val Tyr Ser Leu Glu Asp Thr Gly           
385                 390                 395                 400           

cag gcc gcc tac gac gtc cac cgc aac ctc cac cag ggc aag gtc ggc       1248
Gln Ala Ala Tyr Asp Val His Arg Asn Leu His Gln Gly Lys Val Gly           
                405                 410                 415               

gtg ctg tgc ctg gcg ccc gag gag ggc ctg ggc gtg cgc gac cgg gag       1296
Val Leu Cys Leu Ala Pro Glu Glu Gly Leu Gly Val Arg Asp Arg Glu           
            420                 425                 430                   

aag cgc gcg cag cac ctc gac gcc atc aac cgc ttc cgg aac atc tga       1344
Lys Arg Ala Gln His Leu Asp Ala Ile Asn Arg Phe Arg Asn Ile               
        435                 440                 445                       


<210>  32
<211>  447
<212>  PRT
<213>  Streptomyces coelicolor

<400>  32

Val Thr Val Lys Asp Ile Leu Asp Ala Ile Gln Ser Pro Asp Ser Thr 
1               5                   10                  15      


Pro Ala Asp Ile Ala Ala Leu Pro Leu Pro Glu Ser Tyr Arg Ala Ile 
            20                  25                  30          


Thr Val His Lys Asp Glu Thr Glu Met Phe Ala Gly Leu Glu Thr Arg 
        35                  40                  45              


Asp Lys Asp Pro Arg Lys Ser Ile His Leu Asp Asp Val Pro Val Pro 
    50                  55                  60                  


Glu Leu Gly Pro Gly Glu Ala Leu Val Ala Val Met Ala Ser Ser Val 
65                  70                  75                  80  


Asn Tyr Asn Ser Val Trp Thr Ser Ile Phe Glu Pro Leu Ser Thr Phe 
                85                  90                  95      


Gly Phe Leu Glu Arg Tyr Gly Arg Val Ser Asp Leu Ala Lys Arg His 
            100                 105                 110         


Asp Leu Pro Tyr His Val Ile Gly Ser Asp Leu Ala Gly Val Val Leu 
        115                 120                 125             


Arg Thr Gly Pro Gly Val Asn Ala Trp Gln Ala Gly Asp Glu Val Val 
    130                 135                 140                 


Ala His Cys Leu Ser Val Glu Leu Glu Ser Ser Asp Gly His Asn Asp 
145                 150                 155                 160 


Thr Met Leu Asp Pro Glu Gln Arg Ile Trp Gly Phe Glu Thr Asn Phe 
                165                 170                 175     


Gly Gly Leu Ala Glu Ile Ala Leu Val Lys Ser Asn Gln Leu Met Pro 
            180                 185                 190         


Lys Pro Asp His Leu Ser Trp Glu Glu Ala Ala Ala Pro Gly Leu Val 
        195                 200                 205             


Asn Ser Thr Ala Tyr Arg Gln Leu Val Ser Arg Asn Gly Ala Gly Met 
    210                 215                 220                 


Lys Gln Gly Asp Asn Val Leu Ile Trp Gly Ala Ser Gly Gly Leu Gly 
225                 230                 235                 240 


Ser Tyr Ala Thr Gln Phe Ala Leu Ala Gly Gly Ala Asn Pro Ile Cys 
                245                 250                 255     


Val Val Ser Ser Pro Gln Lys Ala Glu Ile Cys Arg Ala Met Gly Ala 
            260                 265                 270         


Glu Ala Ile Ile Asp Arg Asn Ala Glu Gly Tyr Arg Phe Trp Lys Asp 
        275                 280                 285             


Glu Asn Thr Gln Asp Pro Lys Glu Trp Lys Arg Phe Gly Lys Arg Ile 
    290                 295                 300                 


Arg Glu Leu Thr Gly Gly Glu Asp Ile Asp Ile Val Phe Glu His Pro 
305                 310                 315                 320 


Gly Arg Glu Thr Phe Gly Ala Ser Val Phe Val Thr Arg Lys Gly Gly 
                325                 330                 335     


Thr Ile Thr Thr Cys Ala Ser Thr Ser Gly Tyr Met His Glu Tyr Asp 
            340                 345                 350         


Asn Arg Tyr Leu Trp Met Ser Leu Lys Arg Ile Ile Gly Ser His Phe 
        355                 360                 365             


Ala Asn Tyr Arg Glu Ala Trp Glu Ala Asn Arg Leu Ile Ala Lys Gly 
    370                 375                 380                 


Arg Ile His Pro Thr Leu Ser Lys Val Tyr Ser Leu Glu Asp Thr Gly 
385                 390                 395                 400 


Gln Ala Ala Tyr Asp Val His Arg Asn Leu His Gln Gly Lys Val Gly 
                405                 410                 415     


Val Leu Cys Leu Ala Pro Glu Glu Gly Leu Gly Val Arg Asp Arg Glu 
            420                 425                 430         


Lys Arg Ala Gln His Leu Asp Ala Ile Asn Arg Phe Arg Asn Ile 
        435                 440                 445         


<210>  33
<211>  398
<212>  PRT
<213>  Treponema denticola


<220>
<221>  misc_feature
<222>  (398)..(398)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Met Ile Val Lys Pro Met Val Arg Asn Asn Ile Cys Leu Asn Ala His 
1               5                   10                  15      


Pro Gln Gly Cys Lys Lys Gly Val Glu Asp Gln Ile Glu Tyr Thr Lys 
            20                  25                  30          


Lys Arg Ile Thr Ala Glu Val Lys Ala Gly Ala Lys Ala Pro Lys Asn 
        35                  40                  45              


Val Leu Val Leu Gly Cys Ser Asn Gly Tyr Gly Leu Ala Ser Arg Ile 
    50                  55                  60                  


Thr Ala Ala Phe Gly Tyr Gly Ala Ala Thr Ile Gly Val Ser Phe Glu 
65                  70                  75                  80  


Lys Ala Gly Ser Glu Thr Lys Tyr Gly Thr Pro Gly Trp Tyr Asn Asn 
                85                  90                  95      


Leu Ala Phe Asp Glu Ala Ala Lys Arg Glu Gly Leu Tyr Ser Val Thr 
            100                 105                 110         


Ile Asp Gly Asp Ala Phe Ser Asp Glu Ile Lys Ala Gln Val Ile Glu 
        115                 120                 125             


Glu Ala Lys Lys Lys Gly Ile Lys Phe Asp Leu Ile Val Tyr Ser Leu 
    130                 135                 140                 


Ala Ser Pro Val Arg Thr Asp Pro Asp Thr Gly Ile Met His Lys Ser 
145                 150                 155                 160 


Val Leu Lys Pro Phe Gly Lys Thr Phe Thr Gly Lys Thr Val Asp Pro 
                165                 170                 175     


Phe Thr Gly Glu Leu Lys Glu Ile Ser Ala Glu Pro Ala Asn Asp Glu 
            180                 185                 190         


Glu Ala Ala Ala Thr Val Lys Val Met Gly Gly Glu Asp Trp Glu Arg 
        195                 200                 205             


Trp Ile Lys Gln Leu Ser Lys Glu Gly Leu Leu Glu Glu Gly Cys Ile 
    210                 215                 220                 


Thr Leu Ala Tyr Ser Tyr Ile Gly Pro Glu Ala Thr Gln Ala Leu Tyr 
225                 230                 235                 240 


Arg Lys Gly Thr Ile Gly Lys Ala Lys Glu His Leu Glu Ala Thr Ala 
                245                 250                 255     


His Arg Leu Asn Lys Glu Asn Pro Ser Ile Arg Ala Phe Val Ser Val 
            260                 265                 270         


Asn Lys Gly Leu Val Thr Arg Ala Ser Ala Val Ile Pro Val Ile Pro 
        275                 280                 285             


Leu Tyr Leu Ala Ser Leu Phe Lys Val Met Lys Glu Lys Gly Asn His 
    290                 295                 300                 


Glu Gly Cys Ile Glu Gln Ile Thr Arg Leu Tyr Ala Glu Arg Leu Tyr 
305                 310                 315                 320 


Arg Lys Asp Gly Thr Ile Pro Val Asp Glu Glu Asn Arg Ile Arg Ile 
                325                 330                 335     


Asp Asp Trp Glu Leu Glu Glu Asp Val Gln Lys Ala Val Ser Ala Leu 
            340                 345                 350         


Met Glu Lys Val Thr Gly Glu Asn Ala Glu Ser Leu Thr Asp Leu Ala 
        355                 360                 365             


Gly Tyr Arg His Asp Phe Leu Ala Ser Asn Gly Phe Asp Val Glu Gly 
    370                 375                 380                 


Ile Asn Tyr Glu Ala Glu Val Glu Arg Phe Asp Arg Ile Xaa 
385                 390                 395             


<210>  34
<211>  1407
<212>  DNA
<213>  Clostridium saccharoperbutylacetonicum


<220>
<221>  CDS
<222>  (1)..(1407)

<400>  34
atg att aaa gac acg cta gtt tct ata aca aaa gat tta aaa tta aaa         48
Met Ile Lys Asp Thr Leu Val Ser Ile Thr Lys Asp Leu Lys Leu Lys           
1               5                   10                  15                

aca aat gtt gaa aat gcc aat cta aag aac tac aag gat gat tct tca         96
Thr Asn Val Glu Asn Ala Asn Leu Lys Asn Tyr Lys Asp Asp Ser Ser           
            20                  25                  30                    

tgt ttc gga gtt ttc gaa aat gtt gaa aat gct ata agc aat gcc gta        144
Cys Phe Gly Val Phe Glu Asn Val Glu Asn Ala Ile Ser Asn Ala Val           
        35                  40                  45                        

cac gca caa aag ata tta tcc ctt cat tat aca aaa gaa caa aga gaa        192
His Ala Gln Lys Ile Leu Ser Leu His Tyr Thr Lys Glu Gln Arg Glu           
    50                  55                  60                            

aaa atc ata act gag ata aga aag gcc gca tta gaa aat aaa gag att        240
Lys Ile Ile Thr Glu Ile Arg Lys Ala Ala Leu Glu Asn Lys Glu Ile           
65                  70                  75                  80            

cta gct aca atg att ctt gaa gaa aca cat atg gga aga tat gaa gat        288
Leu Ala Thr Met Ile Leu Glu Glu Thr His Met Gly Arg Tyr Glu Asp           
                85                  90                  95                

aaa ata tta aag cat gaa tta gta gct aaa tac act cct ggg aca gaa        336
Lys Ile Leu Lys His Glu Leu Val Ala Lys Tyr Thr Pro Gly Thr Glu           
            100                 105                 110                   

gat tta act act act gct tgg tca gga gat aac ggg ctt aca gtt gta        384
Asp Leu Thr Thr Thr Ala Trp Ser Gly Asp Asn Gly Leu Thr Val Val           
        115                 120                 125                       

gaa atg tct cca tat ggc gtt ata ggt gca ata act cct tct acg aat        432
Glu Met Ser Pro Tyr Gly Val Ile Gly Ala Ile Thr Pro Ser Thr Asn           
    130                 135                 140                           

cca act gaa act gta ata tgt aat agt ata ggc atg ata gct gct gga        480
Pro Thr Glu Thr Val Ile Cys Asn Ser Ile Gly Met Ile Ala Ala Gly           
145                 150                 155                 160           

aat act gtg gta ttt aac gga cat cca ggc gct aaa aaa tgt gtt gct        528
Asn Thr Val Val Phe Asn Gly His Pro Gly Ala Lys Lys Cys Val Ala           
                165                 170                 175               

ttt gct gtc gaa atg ata aat aaa gct att att tca tgt ggt ggt cct        576
Phe Ala Val Glu Met Ile Asn Lys Ala Ile Ile Ser Cys Gly Gly Pro           
            180                 185                 190                   

gag aat tta gta aca act ata aaa aat cca act atg gac tct cta gat        624
Glu Asn Leu Val Thr Thr Ile Lys Asn Pro Thr Met Asp Ser Leu Asp           
        195                 200                 205                       

gca att att aag cac cct tca ata aaa cta ctt tgc gga act gga ggg        672
Ala Ile Ile Lys His Pro Ser Ile Lys Leu Leu Cys Gly Thr Gly Gly           
    210                 215                 220                           

cca gga atg gta aaa acc ctc tta aat tct ggt aag aaa gct ata ggt        720
Pro Gly Met Val Lys Thr Leu Leu Asn Ser Gly Lys Lys Ala Ile Gly           
225                 230                 235                 240           

gct ggt gct gga aat cca cca gtt att gta gat gat act gct gat ata        768
Ala Gly Ala Gly Asn Pro Pro Val Ile Val Asp Asp Thr Ala Asp Ile           
                245                 250                 255               

gaa aag gct ggt aag agt atc att gaa ggc tgt tct ttt gat aat aat        816
Glu Lys Ala Gly Lys Ser Ile Ile Glu Gly Cys Ser Phe Asp Asn Asn           
            260                 265                 270                   

tta cct tgt att gca gaa aaa gaa gta ttt gtt ttt gag aac gtt gca        864
Leu Pro Cys Ile Ala Glu Lys Glu Val Phe Val Phe Glu Asn Val Ala           
        275                 280                 285                       

gat gat tta ata tct aac atg cta aaa aat aat gct gta att ata aat        912
Asp Asp Leu Ile Ser Asn Met Leu Lys Asn Asn Ala Val Ile Ile Asn           
    290                 295                 300                           

gaa gat caa gta tca aag tta ata gat tta gta tta caa aaa aat aat        960
Glu Asp Gln Val Ser Lys Leu Ile Asp Leu Val Leu Gln Lys Asn Asn           
305                 310                 315                 320           

gaa act caa gaa tac tct ata aat aag aaa tgg gtc gga aaa gat gca       1008
Glu Thr Gln Glu Tyr Ser Ile Asn Lys Lys Trp Val Gly Lys Asp Ala           
                325                 330                 335               

aaa tta ttc tta gat gaa ata gat gtt gag tct cct tca agt gtt aaa       1056
Lys Leu Phe Leu Asp Glu Ile Asp Val Glu Ser Pro Ser Ser Val Lys           
            340                 345                 350                   

tgc ata atc tgc gaa gta agt gca agg cat cca ttt gtt atg aca gaa       1104
Cys Ile Ile Cys Glu Val Ser Ala Arg His Pro Phe Val Met Thr Glu           
        355                 360                 365                       

ctc atg atg cca ata tta cca att gta aga gtt aaa gat ata gat gaa       1152
Leu Met Met Pro Ile Leu Pro Ile Val Arg Val Lys Asp Ile Asp Glu           
    370                 375                 380                           

gct att gaa tat gca aaa ata gca gaa caa aat aga aaa cat agt gcc       1200
Ala Ile Glu Tyr Ala Lys Ile Ala Glu Gln Asn Arg Lys His Ser Ala           
385                 390                 395                 400           

tat att tat tca aaa aat ata gac aac cta aat agg ttt gaa aga gaa       1248
Tyr Ile Tyr Ser Lys Asn Ile Asp Asn Leu Asn Arg Phe Glu Arg Glu           
                405                 410                 415               

atc gat act act atc ttt gta aag aat gct aaa tct ttt gcc ggt gtt       1296
Ile Asp Thr Thr Ile Phe Val Lys Asn Ala Lys Ser Phe Ala Gly Val           
            420                 425                 430                   

ggt tat gaa gca gaa ggc ttt aca act ttc act att gct gga tcc act       1344
Gly Tyr Glu Ala Glu Gly Phe Thr Thr Phe Thr Ile Ala Gly Ser Thr           
        435                 440                 445                       

ggt gaa gga ata act tct gca aga aat ttt aca aga caa aga aga tgt       1392
Gly Glu Gly Ile Thr Ser Ala Arg Asn Phe Thr Arg Gln Arg Arg Cys           
    450                 455                 460                           

gta ctc gcc ggt taa                                                   1407
Val Leu Ala Gly                                                           
465                                                                       


<210>  35
<211>  468
<212>  PRT
<213>  Clostridium saccharoperbutylacetonicum

<400>  35

Met Ile Lys Asp Thr Leu Val Ser Ile Thr Lys Asp Leu Lys Leu Lys 
1               5                   10                  15      


Thr Asn Val Glu Asn Ala Asn Leu Lys Asn Tyr Lys Asp Asp Ser Ser 
            20                  25                  30          


Cys Phe Gly Val Phe Glu Asn Val Glu Asn Ala Ile Ser Asn Ala Val 
        35                  40                  45              


His Ala Gln Lys Ile Leu Ser Leu His Tyr Thr Lys Glu Gln Arg Glu 
    50                  55                  60                  


Lys Ile Ile Thr Glu Ile Arg Lys Ala Ala Leu Glu Asn Lys Glu Ile 
65                  70                  75                  80  


Leu Ala Thr Met Ile Leu Glu Glu Thr His Met Gly Arg Tyr Glu Asp 
                85                  90                  95      


Lys Ile Leu Lys His Glu Leu Val Ala Lys Tyr Thr Pro Gly Thr Glu 
            100                 105                 110         


Asp Leu Thr Thr Thr Ala Trp Ser Gly Asp Asn Gly Leu Thr Val Val 
        115                 120                 125             


Glu Met Ser Pro Tyr Gly Val Ile Gly Ala Ile Thr Pro Ser Thr Asn 
    130                 135                 140                 


Pro Thr Glu Thr Val Ile Cys Asn Ser Ile Gly Met Ile Ala Ala Gly 
145                 150                 155                 160 


Asn Thr Val Val Phe Asn Gly His Pro Gly Ala Lys Lys Cys Val Ala 
                165                 170                 175     


Phe Ala Val Glu Met Ile Asn Lys Ala Ile Ile Ser Cys Gly Gly Pro 
            180                 185                 190         


Glu Asn Leu Val Thr Thr Ile Lys Asn Pro Thr Met Asp Ser Leu Asp 
        195                 200                 205             


Ala Ile Ile Lys His Pro Ser Ile Lys Leu Leu Cys Gly Thr Gly Gly 
    210                 215                 220                 


Pro Gly Met Val Lys Thr Leu Leu Asn Ser Gly Lys Lys Ala Ile Gly 
225                 230                 235                 240 


Ala Gly Ala Gly Asn Pro Pro Val Ile Val Asp Asp Thr Ala Asp Ile 
                245                 250                 255     


Glu Lys Ala Gly Lys Ser Ile Ile Glu Gly Cys Ser Phe Asp Asn Asn 
            260                 265                 270         


Leu Pro Cys Ile Ala Glu Lys Glu Val Phe Val Phe Glu Asn Val Ala 
        275                 280                 285             


Asp Asp Leu Ile Ser Asn Met Leu Lys Asn Asn Ala Val Ile Ile Asn 
    290                 295                 300                 


Glu Asp Gln Val Ser Lys Leu Ile Asp Leu Val Leu Gln Lys Asn Asn 
305                 310                 315                 320 


Glu Thr Gln Glu Tyr Ser Ile Asn Lys Lys Trp Val Gly Lys Asp Ala 
                325                 330                 335     


Lys Leu Phe Leu Asp Glu Ile Asp Val Glu Ser Pro Ser Ser Val Lys 
            340                 345                 350         


Cys Ile Ile Cys Glu Val Ser Ala Arg His Pro Phe Val Met Thr Glu 
        355                 360                 365             


Leu Met Met Pro Ile Leu Pro Ile Val Arg Val Lys Asp Ile Asp Glu 
    370                 375                 380                 


Ala Ile Glu Tyr Ala Lys Ile Ala Glu Gln Asn Arg Lys His Ser Ala 
385                 390                 395                 400 


Tyr Ile Tyr Ser Lys Asn Ile Asp Asn Leu Asn Arg Phe Glu Arg Glu 
                405                 410                 415     


Ile Asp Thr Thr Ile Phe Val Lys Asn Ala Lys Ser Phe Ala Gly Val 
            420                 425                 430         


Gly Tyr Glu Ala Glu Gly Phe Thr Thr Phe Thr Ile Ala Gly Ser Thr 
        435                 440                 445             


Gly Glu Gly Ile Thr Ser Ala Arg Asn Phe Thr Arg Gln Arg Arg Cys 
    450                 455                 460                 


Val Leu Ala Gly 
465             


<210>  36
<211>  1164
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(1164)

<400>  36
atg aac aac ttt aat ctg cac acc cca acc cgc att ctg ttt ggt aaa         48
Met Asn Asn Phe Asn Leu His Thr Pro Thr Arg Ile Leu Phe Gly Lys           
1               5                   10                  15                

ggc gca atc gct ggt tta cgc gaa caa att cct cac gat gct cgc gta         96
Gly Ala Ile Ala Gly Leu Arg Glu Gln Ile Pro His Asp Ala Arg Val           
            20                  25                  30                    

ttg att acc tac ggc ggc ggc agc gtg aaa aaa acc ggc gtt ctc gat        144
Leu Ile Thr Tyr Gly Gly Gly Ser Val Lys Lys Thr Gly Val Leu Asp           
        35                  40                  45                        

caa gtt ctg gat gcc ctg aaa ggc atg gac gtg ctg gaa ttt ggc ggt        192
Gln Val Leu Asp Ala Leu Lys Gly Met Asp Val Leu Glu Phe Gly Gly           
    50                  55                  60                            

att gag cca aac ccg gct tat gaa acg ctg atg aac gcc gtg aaa ctg        240
Ile Glu Pro Asn Pro Ala Tyr Glu Thr Leu Met Asn Ala Val Lys Leu           
65                  70                  75                  80            

gtt cgc gaa cag aaa gtg act ttc ctg ctg gcg gtt ggc ggc ggt tct        288
Val Arg Glu Gln Lys Val Thr Phe Leu Leu Ala Val Gly Gly Gly Ser           
                85                  90                  95                

gta ctg gac ggc acc aaa ttt atc gcc gca gcg gct aac tat ccg gaa        336
Val Leu Asp Gly Thr Lys Phe Ile Ala Ala Ala Ala Asn Tyr Pro Glu           
            100                 105                 110                   

aat atc gat ccg tgg cac att ctg caa acg ggc ggt aaa gag att aaa        384
Asn Ile Asp Pro Trp His Ile Leu Gln Thr Gly Gly Lys Glu Ile Lys           
        115                 120                 125                       

agc gcc atc ccg atg ggc tgt gtg ctg acg ctg cca gca acc ggt tca        432
Ser Ala Ile Pro Met Gly Cys Val Leu Thr Leu Pro Ala Thr Gly Ser           
    130                 135                 140                           

gaa tcc aac gca ggc gcg gtg atc tcc cgt aaa acc aca ggc gac aag        480
Glu Ser Asn Ala Gly Ala Val Ile Ser Arg Lys Thr Thr Gly Asp Lys           
145                 150                 155                 160           

cag gcg ttc cat tct gcc cat gtt cag ccg gta ttt gcc gtg ctc gat        528
Gln Ala Phe His Ser Ala His Val Gln Pro Val Phe Ala Val Leu Asp           
                165                 170                 175               

ccg gtt tat acc tac acc ctg ccg ccg cgt cag gtg gct aac ggc gta        576
Pro Val Tyr Thr Tyr Thr Leu Pro Pro Arg Gln Val Ala Asn Gly Val           
            180                 185                 190                   

gtg gac gcc ttt gta cac acc gtg gaa cag tat gtt acc aaa ccg gtt        624
Val Asp Ala Phe Val His Thr Val Glu Gln Tyr Val Thr Lys Pro Val           
        195                 200                 205                       

gat gcc aaa att cag gac cgt ttc gca gaa ggc att ttg ctg acg cta        672
Asp Ala Lys Ile Gln Asp Arg Phe Ala Glu Gly Ile Leu Leu Thr Leu           
    210                 215                 220                           

atc gaa gat ggt ccg aaa gcc ctg aaa gag cca gaa aac tac gat gtg        720
Ile Glu Asp Gly Pro Lys Ala Leu Lys Glu Pro Glu Asn Tyr Asp Val           
225                 230                 235                 240           

cgc gcc aac gtc atg tgg gcg gcg act cag gcg ctg aac ggt ttg att        768
Arg Ala Asn Val Met Trp Ala Ala Thr Gln Ala Leu Asn Gly Leu Ile           
                245                 250                 255               

ggc gct ggc gta ccg cag gac tgg gca acg cat atg ctg ggc cac gaa        816
Gly Ala Gly Val Pro Gln Asp Trp Ala Thr His Met Leu Gly His Glu           
            260                 265                 270                   

ctg act gcg atg cac ggt ctg gat cac gcg caa aca ctg gct atc gtc        864
Leu Thr Ala Met His Gly Leu Asp His Ala Gln Thr Leu Ala Ile Val           
        275                 280                 285                       

ctg cct gca ctg tgg aat gaa aaa cgc gat acc aag cgc gct aag ctg        912
Leu Pro Ala Leu Trp Asn Glu Lys Arg Asp Thr Lys Arg Ala Lys Leu           
    290                 295                 300                           

ctg caa tat gct gaa cgc gtc tgg aac atc act gaa ggt tcc gat gat        960
Leu Gln Tyr Ala Glu Arg Val Trp Asn Ile Thr Glu Gly Ser Asp Asp           
305                 310                 315                 320           

gag cgt att gac gcc gcg att gcc gca acc cgc aat ttc ttt gag caa       1008
Glu Arg Ile Asp Ala Ala Ile Ala Ala Thr Arg Asn Phe Phe Glu Gln           
                325                 330                 335               

tta ggc gtg ccg acc cac ctc tcc gac tac ggt ctg gac ggc agc tcc       1056
Leu Gly Val Pro Thr His Leu Ser Asp Tyr Gly Leu Asp Gly Ser Ser           
            340                 345                 350                   

atc ccg gct ttg ctg aaa aaa ctg gaa gag cac ggc atg acc caa ctg       1104
Ile Pro Ala Leu Leu Lys Lys Leu Glu Glu His Gly Met Thr Gln Leu           
        355                 360                 365                       

ggc gaa aat cat gac att acg ttg gat gtc agc cgc cgt ata tac gaa       1152
Gly Glu Asn His Asp Ile Thr Leu Asp Val Ser Arg Arg Ile Tyr Glu           
    370                 375                 380                           

gcc gcc cgc taa                                                       1164
Ala Ala Arg                                                               
385                                                                       


<210>  37
<211>  387
<212>  PRT
<213>  Escherichia coli

<400>  37

Met Asn Asn Phe Asn Leu His Thr Pro Thr Arg Ile Leu Phe Gly Lys 
1               5                   10                  15      


Gly Ala Ile Ala Gly Leu Arg Glu Gln Ile Pro His Asp Ala Arg Val 
            20                  25                  30          


Leu Ile Thr Tyr Gly Gly Gly Ser Val Lys Lys Thr Gly Val Leu Asp 
        35                  40                  45              


Gln Val Leu Asp Ala Leu Lys Gly Met Asp Val Leu Glu Phe Gly Gly 
    50                  55                  60                  


Ile Glu Pro Asn Pro Ala Tyr Glu Thr Leu Met Asn Ala Val Lys Leu 
65                  70                  75                  80  


Val Arg Glu Gln Lys Val Thr Phe Leu Leu Ala Val Gly Gly Gly Ser 
                85                  90                  95      


Val Leu Asp Gly Thr Lys Phe Ile Ala Ala Ala Ala Asn Tyr Pro Glu 
            100                 105                 110         


Asn Ile Asp Pro Trp His Ile Leu Gln Thr Gly Gly Lys Glu Ile Lys 
        115                 120                 125             


Ser Ala Ile Pro Met Gly Cys Val Leu Thr Leu Pro Ala Thr Gly Ser 
    130                 135                 140                 


Glu Ser Asn Ala Gly Ala Val Ile Ser Arg Lys Thr Thr Gly Asp Lys 
145                 150                 155                 160 


Gln Ala Phe His Ser Ala His Val Gln Pro Val Phe Ala Val Leu Asp 
                165                 170                 175     


Pro Val Tyr Thr Tyr Thr Leu Pro Pro Arg Gln Val Ala Asn Gly Val 
            180                 185                 190         


Val Asp Ala Phe Val His Thr Val Glu Gln Tyr Val Thr Lys Pro Val 
        195                 200                 205             


Asp Ala Lys Ile Gln Asp Arg Phe Ala Glu Gly Ile Leu Leu Thr Leu 
    210                 215                 220                 


Ile Glu Asp Gly Pro Lys Ala Leu Lys Glu Pro Glu Asn Tyr Asp Val 
225                 230                 235                 240 


Arg Ala Asn Val Met Trp Ala Ala Thr Gln Ala Leu Asn Gly Leu Ile 
                245                 250                 255     


Gly Ala Gly Val Pro Gln Asp Trp Ala Thr His Met Leu Gly His Glu 
            260                 265                 270         


Leu Thr Ala Met His Gly Leu Asp His Ala Gln Thr Leu Ala Ile Val 
        275                 280                 285             


Leu Pro Ala Leu Trp Asn Glu Lys Arg Asp Thr Lys Arg Ala Lys Leu 
    290                 295                 300                 


Leu Gln Tyr Ala Glu Arg Val Trp Asn Ile Thr Glu Gly Ser Asp Asp 
305                 310                 315                 320 


Glu Arg Ile Asp Ala Ala Ile Ala Ala Thr Arg Asn Phe Phe Glu Gln 
                325                 330                 335     


Leu Gly Val Pro Thr His Leu Ser Asp Tyr Gly Leu Asp Gly Ser Ser 
            340                 345                 350         


Ile Pro Ala Leu Leu Lys Lys Leu Glu Glu His Gly Met Thr Gln Leu 
        355                 360                 365             


Gly Glu Asn His Asp Ile Thr Leu Asp Val Ser Arg Arg Ile Tyr Glu 
    370                 375                 380                 


Ala Ala Arg 
385         


<210>  38
<211>  2577
<212>  DNA
<213>  Clostridium acetobutylicum


<220>
<221>  CDS
<222>  (1)..(2577)

<400>  38
atg aaa gtt aca aat caa aaa gaa cta aaa caa aag cta aat gaa ttg         48
Met Lys Val Thr Asn Gln Lys Glu Leu Lys Gln Lys Leu Asn Glu Leu           
1               5                   10                  15                

aga gaa gcg caa aag aag ttt gca acc tat act caa gag caa gtt gat         96
Arg Glu Ala Gln Lys Lys Phe Ala Thr Tyr Thr Gln Glu Gln Val Asp           
            20                  25                  30                    

aaa att ttt aaa caa tgt gcc ata gcc gca gct aaa gaa aga ata aac        144
Lys Ile Phe Lys Gln Cys Ala Ile Ala Ala Ala Lys Glu Arg Ile Asn           
        35                  40                  45                        

tta gct aaa tta gca gta gaa gaa aca gga ata ggt ctt gta gaa gat        192
Leu Ala Lys Leu Ala Val Glu Glu Thr Gly Ile Gly Leu Val Glu Asp           
    50                  55                  60                            

aaa att ata aaa aat cat ttt gca gca gaa tat ata tac aat aaa tat        240
Lys Ile Ile Lys Asn His Phe Ala Ala Glu Tyr Ile Tyr Asn Lys Tyr           
65                  70                  75                  80            

aaa aat gaa aaa act tgt ggc ata ata gac cat gac gat tct tta ggc        288
Lys Asn Glu Lys Thr Cys Gly Ile Ile Asp His Asp Asp Ser Leu Gly           
                85                  90                  95                

ata aca aag gtt gct gaa cca att gga att gtt gca gcc ata gtt cct        336
Ile Thr Lys Val Ala Glu Pro Ile Gly Ile Val Ala Ala Ile Val Pro           
            100                 105                 110                   

act act aat cca act tcc aca gca att ttc aaa tca tta att tct tta        384
Thr Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ser Leu           
        115                 120                 125                       

aaa aca aga aac gca ata ttc ttt tca cca cat cca cgt gca aaa aaa        432
Lys Thr Arg Asn Ala Ile Phe Phe Ser Pro His Pro Arg Ala Lys Lys           
    130                 135                 140                           

tct aca att gct gca gca aaa tta att tta gat gca gct gtt aaa gca        480
Ser Thr Ile Ala Ala Ala Lys Leu Ile Leu Asp Ala Ala Val Lys Ala           
145                 150                 155                 160           

gga gca cct aaa aat ata ata ggc tgg ata gat gag cca tca ata gaa        528
Gly Ala Pro Lys Asn Ile Ile Gly Trp Ile Asp Glu Pro Ser Ile Glu           
                165                 170                 175               

ctt tct caa gat ttg atg agt gaa gct gat ata ata tta gca aca gga        576
Leu Ser Gln Asp Leu Met Ser Glu Ala Asp Ile Ile Leu Ala Thr Gly           
            180                 185                 190                   

ggt cct tca atg gtt aaa gcg gcc tat tca tct gga aaa cct gca att        624
Gly Pro Ser Met Val Lys Ala Ala Tyr Ser Ser Gly Lys Pro Ala Ile           
        195                 200                 205                       

ggt gtt gga gca gga aat aca cca gca ata ata gat gag agt gca gat        672
Gly Val Gly Ala Gly Asn Thr Pro Ala Ile Ile Asp Glu Ser Ala Asp           
    210                 215                 220                           

ata gat atg gca gta agc tcc ata att tta tca aag act tat gac aat        720
Ile Asp Met Ala Val Ser Ser Ile Ile Leu Ser Lys Thr Tyr Asp Asn           
225                 230                 235                 240           

gga gta ata tgc gct tct gaa caa tca ata tta gtt atg aat tca ata        768
Gly Val Ile Cys Ala Ser Glu Gln Ser Ile Leu Val Met Asn Ser Ile           
                245                 250                 255               

tac gaa aaa gtt aaa gag gaa ttt gta aaa cga gga tca tat ata ctc        816
Tyr Glu Lys Val Lys Glu Glu Phe Val Lys Arg Gly Ser Tyr Ile Leu           
            260                 265                 270                   

aat caa aat gaa ata gct aaa ata aaa gaa act atg ttt aaa aat gga        864
Asn Gln Asn Glu Ile Ala Lys Ile Lys Glu Thr Met Phe Lys Asn Gly           
        275                 280                 285                       

gct att aat gct gac ata gtt gga aaa tct gct tat ata att gct aaa        912
Ala Ile Asn Ala Asp Ile Val Gly Lys Ser Ala Tyr Ile Ile Ala Lys           
    290                 295                 300                           

atg gca gga att gaa gtt cct caa act aca aag ata ctt ata ggc gaa        960
Met Ala Gly Ile Glu Val Pro Gln Thr Thr Lys Ile Leu Ile Gly Glu           
305                 310                 315                 320           

gta caa tct gtt gaa aaa agc gag ctg ttc tca cat gaa aaa cta tca       1008
Val Gln Ser Val Glu Lys Ser Glu Leu Phe Ser His Glu Lys Leu Ser           
                325                 330                 335               

cca gta ctt gca atg tat aaa gtt aag gat ttt gat gaa gct cta aaa       1056
Pro Val Leu Ala Met Tyr Lys Val Lys Asp Phe Asp Glu Ala Leu Lys           
            340                 345                 350                   

aag gca caa agg cta ata gaa tta ggt gga agt gga cac acg tca tct       1104
Lys Ala Gln Arg Leu Ile Glu Leu Gly Gly Ser Gly His Thr Ser Ser           
        355                 360                 365                       

tta tat ata gat tca caa aac aat aag gat aaa gtt aaa gaa ttt gga       1152
Leu Tyr Ile Asp Ser Gln Asn Asn Lys Asp Lys Val Lys Glu Phe Gly           
    370                 375                 380                           

tta gca atg aaa act tca agg aca ttt att aac atg cct tct tca cag       1200
Leu Ala Met Lys Thr Ser Arg Thr Phe Ile Asn Met Pro Ser Ser Gln           
385                 390                 395                 400           

gga gca agc gga gat tta tac aat ttt gcg ata gca cca tca ttt act       1248
Gly Ala Ser Gly Asp Leu Tyr Asn Phe Ala Ile Ala Pro Ser Phe Thr           
                405                 410                 415               

ctt gga tgc ggc act tgg gga gga aac tct gta tcg caa aat gta gag       1296
Leu Gly Cys Gly Thr Trp Gly Gly Asn Ser Val Ser Gln Asn Val Glu           
            420                 425                 430                   

cct aaa cat tta tta aat att aaa agt gtt gct gaa aga agg gaa aat       1344
Pro Lys His Leu Leu Asn Ile Lys Ser Val Ala Glu Arg Arg Glu Asn           
        435                 440                 445                       

atg ctt tgg ttt aaa gtg cca caa aaa ata tat ttt aaa tat gga tgt       1392
Met Leu Trp Phe Lys Val Pro Gln Lys Ile Tyr Phe Lys Tyr Gly Cys           
    450                 455                 460                           

ctt aga ttt gca tta aaa gaa tta aaa gat atg aat aag aaa aga gcc       1440
Leu Arg Phe Ala Leu Lys Glu Leu Lys Asp Met Asn Lys Lys Arg Ala           
465                 470                 475                 480           

ttt ata gta aca gat aaa gat ctt ttt aaa ctt gga tat gtt aat aaa       1488
Phe Ile Val Thr Asp Lys Asp Leu Phe Lys Leu Gly Tyr Val Asn Lys           
                485                 490                 495               

ata aca aag gta cta gat gag ata gat att aaa tac agt ata ttt aca       1536
Ile Thr Lys Val Leu Asp Glu Ile Asp Ile Lys Tyr Ser Ile Phe Thr           
            500                 505                 510                   

gat att aaa tct gat cca act att gat tca gta aaa aaa ggt gct aaa       1584
Asp Ile Lys Ser Asp Pro Thr Ile Asp Ser Val Lys Lys Gly Ala Lys           
        515                 520                 525                       

gaa atg ctt aac ttt gaa cct gat act ata atc tct att ggt ggt gga       1632
Glu Met Leu Asn Phe Glu Pro Asp Thr Ile Ile Ser Ile Gly Gly Gly           
    530                 535                 540                           

tcg cca atg gat gca gca aag gtt atg cac ttg tta tat gaa tat cca       1680
Ser Pro Met Asp Ala Ala Lys Val Met His Leu Leu Tyr Glu Tyr Pro           
545                 550                 555                 560           

gaa gca gaa att gaa aat cta gct ata aac ttt atg gat ata aga aag       1728
Glu Ala Glu Ile Glu Asn Leu Ala Ile Asn Phe Met Asp Ile Arg Lys           
                565                 570                 575               

aga ata tgc aat ttc cct aaa tta ggt aca aag gcg att tca gta gct       1776
Arg Ile Cys Asn Phe Pro Lys Leu Gly Thr Lys Ala Ile Ser Val Ala           
            580                 585                 590                   

att cct aca act gct ggt acc ggt tca gag gca aca cct ttt gca gtt       1824
Ile Pro Thr Thr Ala Gly Thr Gly Ser Glu Ala Thr Pro Phe Ala Val           
        595                 600                 605                       

ata act aat gat gaa aca gga atg aaa tac cct tta act tct tat gaa       1872
Ile Thr Asn Asp Glu Thr Gly Met Lys Tyr Pro Leu Thr Ser Tyr Glu           
    610                 615                 620                           

ttg acc cca aac atg gca ata ata gat act gaa tta atg tta aat atg       1920
Leu Thr Pro Asn Met Ala Ile Ile Asp Thr Glu Leu Met Leu Asn Met           
625                 630                 635                 640           

cct aga aaa tta aca gca gca act gga ata gat gca tta gtt cat gct       1968
Pro Arg Lys Leu Thr Ala Ala Thr Gly Ile Asp Ala Leu Val His Ala           
                645                 650                 655               

ata gaa gca tat gtt tcg gtt atg gct acg gat tat act gat gaa tta       2016
Ile Glu Ala Tyr Val Ser Val Met Ala Thr Asp Tyr Thr Asp Glu Leu           
            660                 665                 670                   

gcc tta aga gca ata aaa atg ata ttt aaa tat ttg cct aga gcc tat       2064
Ala Leu Arg Ala Ile Lys Met Ile Phe Lys Tyr Leu Pro Arg Ala Tyr           
        675                 680                 685                       

aaa aat ggg act aac gac att gaa gca aga gaa aaa atg gca cat gcc       2112
Lys Asn Gly Thr Asn Asp Ile Glu Ala Arg Glu Lys Met Ala His Ala           
    690                 695                 700                           

tct aat att gcg ggg atg gca ttt gca aat gct ttc tta ggt gta tgc       2160
Ser Asn Ile Ala Gly Met Ala Phe Ala Asn Ala Phe Leu Gly Val Cys           
705                 710                 715                 720           

cat tca atg gct cat aaa ctt ggg gca atg cat cac gtt cca cat gga       2208
His Ser Met Ala His Lys Leu Gly Ala Met His His Val Pro His Gly           
                725                 730                 735               

att gct tgt gct gta tta ata gaa gaa gtt att aaa tat aac gct aca       2256
Ile Ala Cys Ala Val Leu Ile Glu Glu Val Ile Lys Tyr Asn Ala Thr           
            740                 745                 750                   

gac tgt cca aca aag caa aca gca ttc cct caa tat aaa tct cct aat       2304
Asp Cys Pro Thr Lys Gln Thr Ala Phe Pro Gln Tyr Lys Ser Pro Asn           
        755                 760                 765                       

gct aag aga aaa tat gct gaa att gca gag tat ttg aat tta aag ggt       2352
Ala Lys Arg Lys Tyr Ala Glu Ile Ala Glu Tyr Leu Asn Leu Lys Gly           
    770                 775                 780                           

act agc gat acc gaa aag gta aca gcc tta ata gaa gct att tca aag       2400
Thr Ser Asp Thr Glu Lys Val Thr Ala Leu Ile Glu Ala Ile Ser Lys           
785                 790                 795                 800           

tta aag ata gat ttg agt att cca caa aat ata agt gcc gct gga ata       2448
Leu Lys Ile Asp Leu Ser Ile Pro Gln Asn Ile Ser Ala Ala Gly Ile           
                805                 810                 815               

aat aaa aaa gat ttt tat aat acg cta gat aaa atg tca gag ctt gct       2496
Asn Lys Lys Asp Phe Tyr Asn Thr Leu Asp Lys Met Ser Glu Leu Ala           
            820                 825                 830                   

ttt gat gac caa tgt aca aca gct aat cct agg tat cca ctt ata agt       2544
Phe Asp Asp Gln Cys Thr Thr Ala Asn Pro Arg Tyr Pro Leu Ile Ser           
        835                 840                 845                       

gaa ctt aag gat atc tat ata aaa tca ttt taa                           2577
Glu Leu Lys Asp Ile Tyr Ile Lys Ser Phe                                   
    850                 855                                               


<210>  39
<211>  858
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  39

Met Lys Val Thr Asn Gln Lys Glu Leu Lys Gln Lys Leu Asn Glu Leu 
1               5                   10                  15      


Arg Glu Ala Gln Lys Lys Phe Ala Thr Tyr Thr Gln Glu Gln Val Asp 
            20                  25                  30          


Lys Ile Phe Lys Gln Cys Ala Ile Ala Ala Ala Lys Glu Arg Ile Asn 
        35                  40                  45              


Leu Ala Lys Leu Ala Val Glu Glu Thr Gly Ile Gly Leu Val Glu Asp 
    50                  55                  60                  


Lys Ile Ile Lys Asn His Phe Ala Ala Glu Tyr Ile Tyr Asn Lys Tyr 
65                  70                  75                  80  


Lys Asn Glu Lys Thr Cys Gly Ile Ile Asp His Asp Asp Ser Leu Gly 
                85                  90                  95      


Ile Thr Lys Val Ala Glu Pro Ile Gly Ile Val Ala Ala Ile Val Pro 
            100                 105                 110         


Thr Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ser Leu 
        115                 120                 125             


Lys Thr Arg Asn Ala Ile Phe Phe Ser Pro His Pro Arg Ala Lys Lys 
    130                 135                 140                 


Ser Thr Ile Ala Ala Ala Lys Leu Ile Leu Asp Ala Ala Val Lys Ala 
145                 150                 155                 160 


Gly Ala Pro Lys Asn Ile Ile Gly Trp Ile Asp Glu Pro Ser Ile Glu 
                165                 170                 175     


Leu Ser Gln Asp Leu Met Ser Glu Ala Asp Ile Ile Leu Ala Thr Gly 
            180                 185                 190         


Gly Pro Ser Met Val Lys Ala Ala Tyr Ser Ser Gly Lys Pro Ala Ile 
        195                 200                 205             


Gly Val Gly Ala Gly Asn Thr Pro Ala Ile Ile Asp Glu Ser Ala Asp 
    210                 215                 220                 


Ile Asp Met Ala Val Ser Ser Ile Ile Leu Ser Lys Thr Tyr Asp Asn 
225                 230                 235                 240 


Gly Val Ile Cys Ala Ser Glu Gln Ser Ile Leu Val Met Asn Ser Ile 
                245                 250                 255     


Tyr Glu Lys Val Lys Glu Glu Phe Val Lys Arg Gly Ser Tyr Ile Leu 
            260                 265                 270         


Asn Gln Asn Glu Ile Ala Lys Ile Lys Glu Thr Met Phe Lys Asn Gly 
        275                 280                 285             


Ala Ile Asn Ala Asp Ile Val Gly Lys Ser Ala Tyr Ile Ile Ala Lys 
    290                 295                 300                 


Met Ala Gly Ile Glu Val Pro Gln Thr Thr Lys Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Val Gln Ser Val Glu Lys Ser Glu Leu Phe Ser His Glu Lys Leu Ser 
                325                 330                 335     


Pro Val Leu Ala Met Tyr Lys Val Lys Asp Phe Asp Glu Ala Leu Lys 
            340                 345                 350         


Lys Ala Gln Arg Leu Ile Glu Leu Gly Gly Ser Gly His Thr Ser Ser 
        355                 360                 365             


Leu Tyr Ile Asp Ser Gln Asn Asn Lys Asp Lys Val Lys Glu Phe Gly 
    370                 375                 380                 


Leu Ala Met Lys Thr Ser Arg Thr Phe Ile Asn Met Pro Ser Ser Gln 
385                 390                 395                 400 


Gly Ala Ser Gly Asp Leu Tyr Asn Phe Ala Ile Ala Pro Ser Phe Thr 
                405                 410                 415     


Leu Gly Cys Gly Thr Trp Gly Gly Asn Ser Val Ser Gln Asn Val Glu 
            420                 425                 430         


Pro Lys His Leu Leu Asn Ile Lys Ser Val Ala Glu Arg Arg Glu Asn 
        435                 440                 445             


Met Leu Trp Phe Lys Val Pro Gln Lys Ile Tyr Phe Lys Tyr Gly Cys 
    450                 455                 460                 


Leu Arg Phe Ala Leu Lys Glu Leu Lys Asp Met Asn Lys Lys Arg Ala 
465                 470                 475                 480 


Phe Ile Val Thr Asp Lys Asp Leu Phe Lys Leu Gly Tyr Val Asn Lys 
                485                 490                 495     


Ile Thr Lys Val Leu Asp Glu Ile Asp Ile Lys Tyr Ser Ile Phe Thr 
            500                 505                 510         


Asp Ile Lys Ser Asp Pro Thr Ile Asp Ser Val Lys Lys Gly Ala Lys 
        515                 520                 525             


Glu Met Leu Asn Phe Glu Pro Asp Thr Ile Ile Ser Ile Gly Gly Gly 
    530                 535                 540                 


Ser Pro Met Asp Ala Ala Lys Val Met His Leu Leu Tyr Glu Tyr Pro 
545                 550                 555                 560 


Glu Ala Glu Ile Glu Asn Leu Ala Ile Asn Phe Met Asp Ile Arg Lys 
                565                 570                 575     


Arg Ile Cys Asn Phe Pro Lys Leu Gly Thr Lys Ala Ile Ser Val Ala 
            580                 585                 590         


Ile Pro Thr Thr Ala Gly Thr Gly Ser Glu Ala Thr Pro Phe Ala Val 
        595                 600                 605             


Ile Thr Asn Asp Glu Thr Gly Met Lys Tyr Pro Leu Thr Ser Tyr Glu 
    610                 615                 620                 


Leu Thr Pro Asn Met Ala Ile Ile Asp Thr Glu Leu Met Leu Asn Met 
625                 630                 635                 640 


Pro Arg Lys Leu Thr Ala Ala Thr Gly Ile Asp Ala Leu Val His Ala 
                645                 650                 655     


Ile Glu Ala Tyr Val Ser Val Met Ala Thr Asp Tyr Thr Asp Glu Leu 
            660                 665                 670         


Ala Leu Arg Ala Ile Lys Met Ile Phe Lys Tyr Leu Pro Arg Ala Tyr 
        675                 680                 685             


Lys Asn Gly Thr Asn Asp Ile Glu Ala Arg Glu Lys Met Ala His Ala 
    690                 695                 700                 


Ser Asn Ile Ala Gly Met Ala Phe Ala Asn Ala Phe Leu Gly Val Cys 
705                 710                 715                 720 


His Ser Met Ala His Lys Leu Gly Ala Met His His Val Pro His Gly 
                725                 730                 735     


Ile Ala Cys Ala Val Leu Ile Glu Glu Val Ile Lys Tyr Asn Ala Thr 
            740                 745                 750         


Asp Cys Pro Thr Lys Gln Thr Ala Phe Pro Gln Tyr Lys Ser Pro Asn 
        755                 760                 765             


Ala Lys Arg Lys Tyr Ala Glu Ile Ala Glu Tyr Leu Asn Leu Lys Gly 
    770                 775                 780                 


Thr Ser Asp Thr Glu Lys Val Thr Ala Leu Ile Glu Ala Ile Ser Lys 
785                 790                 795                 800 


Leu Lys Ile Asp Leu Ser Ile Pro Gln Asn Ile Ser Ala Ala Gly Ile 
                805                 810                 815     


Asn Lys Lys Asp Phe Tyr Asn Thr Leu Asp Lys Met Ser Glu Leu Ala 
            820                 825                 830         


Phe Asp Asp Gln Cys Thr Thr Ala Asn Pro Arg Tyr Pro Leu Ile Ser 
        835                 840                 845             


Glu Leu Lys Asp Ile Tyr Ile Lys Ser Phe 
    850                 855             


