                         SEQUENCE LISTING

<110>  BAYER HEALTHCARE LLC
       Jin, Ye
       Murphy, John E.
       Hermiston, Terry
       Myles, Timothy
       Dittmer, Frank
       Strerath, Michael
       Gritzan, Uwe
 
<120>  Monoclonal Antibodies Against Antithrombin Beta

<130>  17207.0006WOU1

<150>  US 61/784,590
<151>  2013-03-14

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2009, Light Chain Variable Region

<400>  1

Ala Gln Ser Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
1               5                   10                  15      


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 
            20                  25                  30          


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        35                  40                  45              


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Ala Glu Cys Ser 
    210                 215 


<210>  2
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2009, Heavy Chain Variable Region

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Arg Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Tyr Ser Ser Gly Gly Arg Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Ala Ser Asp Leu Ser Gly Ser Phe Ser Glu Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  3
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2015, Light Chain Variable Region

<400>  3

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
            20                  25                  30          


Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser 
                85                  90                  95      


Ser Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  4
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2015, Heavy Chain Variable Region

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Lys Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Gly Pro Ser Gly Gly Lys Thr Met Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Ala Ser Asp Leu Ser Gly Thr Tyr Ser Glu Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  5
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2016, Light Chain Variable Region

<400>  5

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn 
            20                  25                  30          


Arg Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile His Thr Ala Ser Thr Arg Ala Pro Gly Val Pro Val Arg Ile 
    50                  55                  60                  


Thr Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Ala Ser Pro 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  6
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2016, Heavy Chain Variable Region

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Arg Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Gly Pro Ser Gly Gly Lys Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Thr Ser Asp Leu Ser Gly Ser Tyr Ser Glu Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  7
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2019, Light Chain Variable Region

<400>  7

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser 
            20                  25                  30          


Ser Ser Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser 
                85                  90                  95      


Thr Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  8
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2019, Heavy Chain Variable Region

<400>  8

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Ser Gly Gly Lys Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Gln Thr Gly Tyr Tyr Pro His Tyr His Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  9
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2803, Light Chain Variable Region

<400>  9

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Ala Glu Cys Ser 
    210                 


<210>  10
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2803, Heavy Chain Variable Region

<400>  10

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Tyr Ser Ser Gly Gly Arg Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Ala Ser Asp Leu Ser Gly Ser Phe Ser Glu Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  11
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP2009 Light Chain_V region

<400>  11
gcacagagcg tcttgactca ggaccctgct gtgtctgtgg ccttgggaca gacagtcagg       60

atcacatgcc aaggagacag cctcagaagc tattatgcaa gctggtacca gcagaagcca      120

ggacaggccc ctgtacttgt catctatggt aaaaacaacc ggccctcagg gatcccagac      180

cgattctctg gctccagctc aggaaacaca gcttccttga ccatcactgg ggctcaggcg      240

gaagatgagg ctgactatta ctgtaactcc cgggacagca gtggtaacca tctggtattc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactagtgtg tctgatcagt      420

gacttctacc cgggagctgt gacagtggcc tggaaggcag atggcagccc cgtcaaggcg      480

ggagtggaga ccaccaaacc ctccaaacag agcaacaaca agtacgcggc cagcagctac      540

ctgagcctga cgcccgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctgcagaat gctct                      645


<210>  12
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP2009 Heavy chain

<400>  12
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct gcttaccgta tgggttgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctcgt atctattctt ctggtggccg tactcgttat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagagaaa      300

gcgtcggatc tatcggggag tttttctgag gcccttgact actggggcca gggaaccctg      360

gtcaccgtct caagcgcctc caccaagggc ccatcggtct tcccgctagc acccagcagc      420

aagagcacca gcggcggaac agccgccctg ggctgcctgg tgaaagacta cttccccgag      480

cccgtgaccg tgtcctggaa ctctggcgcc ctgaccagcg gagtgcatac cttccccgcc      540

gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgacagtgcc cagcagcagc      600

ctgggaaccc agacctacat ctgcaacgtg aaccacaagc ccagcaacac caaggtggac      660

aagaaggtgg aacccaagag ctgcgacaag acccacacct gtcccccctg ccctgcccct      720

gaactgctgg gcggacccag cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atcagccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccacga ggacccagaa      840

gtgaagttta attggtacgt ggacggcgtg gaagtgcata acgccaagac caagcccaga      900

gaggaacagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtctccaaca aggccctgcc tgcccccatc     1020

gagaaaacca tcagcaaggc caagggccag ccccgcgagc ctcaggtgta cacactgccc     1080

cccagccggg atgagctgac caagaaccag gtgtccctga cctgtctggt gaaaggcttc     1140

taccccagcg atatcgccgt ggaatgggag agcaacggcc agcccgagaa caattacaag     1200

accacccccc ctgtgctgga cagcgacggc tcattcttcc tgtactccaa gctgaccgtg     1260

gacaagagcc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1320

cacaatcact acacccagaa gtccctgagc ctgagccccg gc                        1362


<210>  13
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP2015 Light Chain_V region

<400>  13
gcacaagaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga       60

gccaccctct cctgcagggc cagtcagagt gttagcagca gctacttagc ctggtaccag      120

cagaaacctg gccaggctcc caggctcctc atctatggtg catccagcag ggccactggc      180

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga      240

cggagcctga agattttgca gtgtattact gtcagcagta tggtagctca acgttcggcc      300

aagggaccaa ggtggaaatc agacgaactg tggctgcaat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  14
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP2015 Heavy Chain

<400>  14
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct aagtacaaga tggattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctcgt atcggtcctt ctggtggcaa gactatgtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagagaaa      300

gcgtcggatc tatcggggac ttattctgag gcccttgact actggggcca gggaaccctg      360

gtcaccgtct caagcgcctc caccaagggc ccatcggtct tcccgctagc acccagcagc      420

aagagcacca gcggcggaac agccgccctg ggctgcctgg tgaaagacta cttccccgag      480

cccgtgaccg tgtcctggaa ctctggcgcc ctgaccagcg gagtgcatac cttccccgcc      540

gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgacagtgcc cagcagcagc      600

ctgggaaccc agacctacat ctgcaacgtg aaccacaagc ccagcaacac caaggtggac      660

aagaaggtgg aacccaagag ctgcgacaag acccacacct gtcccccctg ccctgcccct      720

gaactgctgg gcggacccag cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atcagccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccacga ggacccagaa      840

gtgaagttta attggtacgt ggacggcgtg gaagtgcata acgccaagac caagcccaga      900

gaggaacagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtctccaaca aggccctgcc tgcccccatc     1020

gagaaaacca tcagcaaggc caagggccag ccccgcgagc ctcaggtgta cacactgccc     1080

cccagccggg atgagctgac caagaaccag gtgtccctga cctgtctggt gaaaggcttc     1140

taccccagcg atatcgccgt ggaatgggag agcaacggcc agcccgagaa caattacaag     1200

accacccccc ctgtgctgga cagcgacggc tcattcttcc tgtactccaa gctgaccgtg     1260

gacaagagcc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1320

cacaatcact acacccagaa gtccctgagc ctgagccccg gc                        1362


<210>  15
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP2016 Light Chain_V region

<400>  15
gcacaagaca tccagatgac ccagtctcca gccaccctgt ctgtgtctcc aggggaaaga       60

gccaccctct cctgcagggc cagtcagaat attaatagaa acttggcctg gtaccagcag      120

aagcctggcc gggctcccag actcctcatc cataccgcat ccactagggc ccctggtgtc      180

ccagtcagga tcactggcag tgggtctgga acagagttca ctctcaccat cagcagcctg      240

gaacctgaag attttgcagt gtatttctgt cagcagtatg ctagcccacc tcggacgttc      300

ggccaaggga ccaaggtgga aatcaagcga actgtggctg caccatctgt cttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648


<210>  16
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP2016 Heavy Chain

<400>  16
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct aagtaccgta tggattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctcgt atcggtcctt ctggtggcaa gactacttat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagagaaa      300

acgtcggatc tatcggggag ttattctgag gcccttgact actggggcca gggaaccctg      360

gtcaccgtct caagcgcctc caccaagggc ccatcggtct tcccgctagc acccagcagc      420

aagagcacca gcggcggaac agccgccctg ggctgcctgg tgaaagacta cttccccgag      480

cccgtgaccg tgtcctggaa ctctggcgcc ctgaccagcg gagtgcatac cttccccgcc      540

gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgacagtgcc cagcagcagc      600

ctgggaaccc agacctacat ctgcaacgtg aaccacaagc ccagcaacac caaggtggac      660

aagaaggtgg aacccaagag ctgcgacaag acccacacct gtcccccctg ccctgcccct      720

gaactgctgg gcggacccag cgtgttcctg ttccccccaa agcccaagga caccctgatg      780

atcagccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccacga ggacccagaa      840

gtgaagttta attggtacgt ggacggcgtg gaagtgcata acgccaagac caagcccaga      900

gaggaacagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac      960

tggctgaacg gcaaagagta caagtgcaag gtctccaaca aggccctgcc tgcccccatc     1020

gagaaaacca tcagcaaggc caagggccag ccccgcgagc ctcaggtgta cacactgccc     1080

cccagccggg atgagctgac caagaaccag gtgtccctga cctgtctggt gaaaggcttc     1140

taccccagcg atatcgccgt ggaatgggag agcaacggcc agcccgagaa caattacaag     1200

accacccccc ctgtgctgga cagcgacggc tcattcttcc tgtactccaa gctgaccgtg     1260

gacaagagcc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1320

cacaatcact acacccagaa gtccctgagc ctgagccccg gc                        1362


<210>  17
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP2019 Light Chain_V region

<400>  17
gcacaagaca tccagatgac ccagtctcca gccaccctgt ctttgtctcc aggggaaaga       60

gccaccctct cctgcagggc cagtcagcgt gttagcagca gctacttaac ctggtaccag      120

cagaaacctg gccaggctcc caggctcctc atctatggtg catccagcag ggccactggc      180

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga      240

ctggagcctg aagattttgc agtttattac tgtcagcagt atgatagtac gcctccgctc      300

accttcggcg gagggaccaa ggtggagatc aaacgaactg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  18
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP2019 Heavy chain

<400>  18
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct cgttacgcta tgtattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctcgt atctctcctt ctggtggcaa gactcattat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagactgtct      300

caaactggtt attaccctca ctaccactac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcaagcgc ctccaccaag ggcccatcgg tcttcccgct agcacccagc      420

agcaagagca ccagcggcgg aacagccgcc ctgggctgcc tggtgaaaga ctacttcccc      480

gagcccgtga ccgtgtcctg gaactctggc gccctgacca gcggagtgca taccttcccc      540

gccgtgctgc agagcagcgg cctgtacagc ctgagcagcg tggtgacagt gcccagcagc      600

agcctgggaa cccagaccta catctgcaac gtgaaccaca agcccagcaa caccaaggtg      660

gacaagaagg tggaacccaa gagctgcgac aagacccaca cctgtccccc ctgccctgcc      720

cctgaactgc tgggcggacc cagcgtgttc ctgttccccc caaagcccaa ggacaccctg      780

atgatcagcc ggacccccga agtgacctgc gtggtggtgg acgtgtccca cgaggaccca      840

gaagtgaagt ttaattggta cgtggacggc gtggaagtgc ataacgccaa gaccaagccc      900

agagaggaac agtacaacag cacctaccgg gtggtgtccg tgctgaccgt gctgcaccag      960

gactggctga acggcaaaga gtacaagtgc aaggtctcca acaaggccct gcctgccccc     1020

atcgagaaaa ccatcagcaa ggccaagggc cagccccgcg agcctcaggt gtacacactg     1080

ccccccagcc gggatgagct gaccaagaac caggtgtccc tgacctgtct ggtgaaaggc     1140

ttctacccca gcgatatcgc cgtggaatgg gagagcaacg gccagcccga gaacaattac     1200

aagaccaccc cccctgtgct ggacagcgac ggctcattct tcctgtactc caagctgacc     1260

gtggacaaga gccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1320

ctgcacaatc actacaccca gaagtccctg agcctgagcc ccggc                     1365


<210>  19
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP2803 Light Chain_V region

<400>  19
agcgaattga ctcaggaccc tgctgtgtct gtggccttgg gacagacagt caggatcaca       60

tgccaaggag acagcctcag aagctattat gcaagctggt accagcagaa gccaggacag      120

gcccctgtac ttgtcatcta tggtaaaaac aaccggccct cagggatccc agaccgattc      180

tctggctcca gctcaggaaa cacagcttcc ttgaccatca ctggggctca ggcggaagat      240

gaggctgact attactgtaa ctcccgggac agcagtggta accatctggt attcggcgga      300

gggaccaagc tgaccgtcct aggtcagccc aaggctgccc cctcggtcac tctgttcccg      360

ccctcctctg aggagcttca agccaacaag gccacactag tgtgtctgat cagtgacttc      420

tacccgggag ctgtgacagt ggcctggaag gcagatggca gccccgtcaa ggcgggagtg      480

gagaccacca aaccctccaa acagagcaac aacaagtacg cggccagcag ctacctgagc      540

ctgacgcccg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      600

agcaccgtgg agaagacagt ggcccctgca gaatgctct                             639


<210>  20
<211>  1348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP2803 Heavy Chain

<400>  20
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcagc agctacagaa tgagctgggt gcgccaggcc      120

cctggcaagg gactggaatg ggtgtcccgg atctacagca gcggcggcag aaccagatac      180

gccgacagcg tgaagggccg gttcaccatc tcccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actattgcgc cagagagaag      300

gccagcgacc tgagcggcag ctttagcgag gccctggatt attggggcca gggcacactc      360

gtgaccgtgt ctagcgccag cacaaagggc cccagcgtgt tccctctggc cccttgtagc      420

agaagcacca gcgagtctac agccgccctg ggctgcctcg tgaaggacta ctttcccgag      480

cccgtgacag tgtcctggaa ctctggcgcc ctgacaagcg gcgtgcacac ctttccagcc      540

gtgctgcaga gcagcggcct gtactctctg agcagcgtcg tgactgtgcc cagcagcaac      600

ttcggcaccc agacctacac ctgtaacgtg gaccacaagc ccagcaacac caaggtggac      660

aagaccgtgg aacggaagtg ctgcgtggaa tgcccccctt gtcctgcccc tccagtggct      720

ggcccttccg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat cagccggacc      780

ccgaagtgac ctgcgtggtg gtggatgtgt cccacgagga ccccgaggtg cagttcaatt      840

ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gcccagagag gaacagttca      900

acagcacctt ccgggtggtg tccgtgctga ccgtggtgca tcaggactgg ctgaacggca      960

aagagtacaa gtgcaaggtg tccaacaagg gcctgcctgc ccccatcgag aaaaccatca     1020

gcaagaccaa aggccagccc cgcgagcccc aggtgtacac actgcctcca agccgggaag     1080

agatgaccaa gaaccaggtg tccctgacct gtctcgtgaa aggcttctac ccctccgata     1140

tcgccgtgga atgggagagc aacggccagc ccgagaacaa ctacaagacc acccccccca     1200

tgctggacag cgcggctcat tcttcctgta cagcaagctg acagtggaca agtcccggtg     1260

gcagcagggc aacgtgttca gctgcagcgt gatgcacgaa gccctgcaca accactacac     1320

ccagaagtcc ctgagcctga gccctggc                                        1348


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2009 LCDR1

<400>  21

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2015 LCDR1

<400>  22

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2016 LCDR1

<400>  23

Arg Ala Ser Gln Asn Ile Asn Arg Asn Leu Ala 
1               5                   10      


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2019 LCDR1

<400>  24

Arg Ala Ser Gln Arg Val Ser Ser Ser Tyr Leu Thr 
1               5                   10          


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2803 LCDR1

<400>  25

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2009 LCDR2

<400>  26

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2015 LCDR2

<400>  27

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2016 LCDR2

<400>  28

Thr Ala Ser Thr Arg Ala Pro 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2019 LCDR2

<400>  29

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2803 LCDR2

<400>  30

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2009 LCDR3

<400>  31

Asn Ser Arg Asp Ser Ser Gly Asn His Leu Val 
1               5                   10      


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2015 LCDR3

<400>  32

Gln Gln Tyr Gly Ser Ser Arg Thr 
1               5               


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2016 LCDR3

<400>  33

Gln Gln Tyr Ala Ser Pro Pro Arg Thr 
1               5                   


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2019 LCDR3

<400>  34

Gln Gln Tyr Asp Ser Thr Pro Pro Leu Thr 
1               5                   10  


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2803 LCDR3

<400>  35

Asn Ser Arg Asp Ser Ser Gly Asn His Leu Val 
1               5                   10      


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2009 HCDR1

<400>  36

Ala Tyr Arg Met Gly 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2015 HCDR1

<400>  37

Lys Tyr Lys Met Asp 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2016 HCDR1

<400>  38

Lys Tyr Arg Met Asp 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2019 HCDR1

<400>  39

Arg Tyr Ala Met Tyr 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2803 HCDR1

<400>  40

Ser Tyr Arg Met Ser 
1               5   


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2009 HCDR2

<400>  41

Arg Ile Tyr Ser Ser Gly Gly Arg Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2015 HCDR2

<400>  42

Arg Ile Gly Pro Ser Gly Gly Lys Thr Met Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2016 HCDR2

<400>  43

Arg Ile Gly Pro Ser Gly Gly Lys Thr Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2019 HCDR2

<400>  44

Arg Ile Ser Pro Ser Gly Gly Lys Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2803 HCDR2

<400>  45

Arg Ile Tyr Ser Ser Gly Gly Arg Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2009 HCDR3

<400>  46

Ala Arg Glu Lys Ala Ser Asp Leu Ser Gly Ser Phe Ser Glu Ala Leu 
1               5                   10                  15      


Asp Tyr 
        


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2015 HCDR3

<400>  47

Ala Arg Glu Lys Ala Ser Asp Leu Ser Gly Thr Tyr Ser Glu Ala Leu 
1               5                   10                  15      


Asp Tyr 
        


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2016 HCDR3

<400>  48

Ala Arg Glu Lys Thr Ser Asp Leu Ser Gly Ser Tyr Ser Glu Ala Leu 
1               5                   10                  15      


Asp Tyr 
        


<210>  49
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2019 HCDR3

<400>  49

Ala Arg Leu Ser Gln Thr Gly Tyr Tyr Pro His Tyr His Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  50
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2803 HCDR3

<400>  50

Ala Arg Glu Lys Ala Ser Asp Leu Ser Gly Ser Phe Ser Glu Ala Leu 
1               5                   10                  15      


Asp Tyr 
        


<210>  51
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2009 , hIgG, Light_Chain

<400>  51

Ala Gln Ser Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
1               5                   10                  15      


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 
            20                  25                  30          


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        35                  40                  45              


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Ala Glu Cys Ser 
    210                 215 


<210>  52
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP2009, hIgG, Heavy_chain

<400>  52

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Arg Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Tyr Ser Ser Gly Gly Arg Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Ala Ser Asp Leu Ser Gly Ser Phe Ser Glu Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  53
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2015, hIgG, light_chain

<400>  53

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
            20                  25                  30          


Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser 
                85                  90                  95      


Ser Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  54
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2015, hIgG, heavy_chain

<400>  54

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Lys Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Gly Pro Ser Gly Gly Lys Thr Met Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Ala Ser Asp Leu Ser Gly Thr Tyr Ser Glu Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Gly 
    450             


<210>  55
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2016, hIgG, light_chain, Kappa

<400>  55

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn 
            20                  25                  30          


Arg Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile His Thr Ala Ser Thr Arg Ala Pro Gly Val Pro Val Arg Ile 
    50                  55                  60                  


Thr Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Ala Ser Pro 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  56
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2016, hIgG, heavy_chain

<400>  56

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Arg Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Gly Pro Ser Gly Gly Lys Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Thr Ser Asp Leu Ser Gly Ser Tyr Ser Glu Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  57
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2019, hIgG, light_chain, Kappa

<400>  57

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser 
            20                  25                  30          


Ser Ser Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser 
                85                  90                  95      


Thr Pro Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  58
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2019, hIgG, heavy_chain

<400>  58

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Ser Gly Gly Lys Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Gln Thr Gly Tyr Tyr Pro His Tyr His Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  59
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2803, hIgG2, light_chain, lambda

<400>  59

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Ala Glu Cys Ser 
    210                 


<210>  60
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2803, hIgG2, heavy_chain

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Arg Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Tyr Ser Ser Gly Gly Arg Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Ala Ser Asp Leu Ser Gly Ser Phe Ser Glu Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


