                               SEQUENCE LISTING

<110> TUFTS UNIVERSITY
 
<120> COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES

<130> 365816.00007

<140> PCT/US2014/029323
<141> 2014-03-14

<150> 61/918,260
<151> 2013-12-19

<150> 61/784,814
<151> 2013-03-14

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 2133
<212> DNA
<213> Trypanosoma cruzi

<400> 1
tgttcccctt ttctcttccc aactttctcc ggcggcaatc cccctgcaaa gagacgatct       60

tgacaccatt gttttaggca taatagaagt tctacaaaca acgcccgaag gacacacagg      120

caggcaccga ctaccatggg gaaaacagtc gttgtggcca gtaggatgtt ctggctaatg      180

tttttcgtgc cgcttcttct tgcgatctgc cccagcgagc ccgcgtacgc cttggcaccc      240

ggatcgagcc gagttgagct gtttaagcgt aagaattcga cggtgccgtt tgaagacaag      300

gccggcaaag tcaccgagcg ggttgtccac tcgttccgcc tccccgccct tgttaatgtg      360

gacggggtga tggttgccat cgcggacgct cgctacgaca catccaatga caactccctc      420

attgatacgg tggcgaagta cagcgtggac gatggggaga cgtgggagac ccaaattgcc      480

atcaagaaca gccgtgtatc gtctgtttct cgtgtggtgg atcccaccgt gattgtgaag      540

ggcaacaagc tttacgtcct ggttggaagc tactatagtt cgagaagcta ctggtcgtcg      600

catggtgatg cgagagactg ggatattctg cttgccgttg gtgaggtcac gaagtccact      660

gcgggcggca agataactgc gagtatcaaa tgggggagcc ccgtgtcact gaagaagttt      720

tttccggcag aaatggaagg catgcacaca aatcaatttc ttggcggcgc gggtgttgcc      780

attgtagcgt ccaacgggaa tcttgtgtac cctgtgcagg ttacgaacaa aaagaagcaa      840

gttttctcca agatcttcta ctcggaagat gatggcaaga cgtggaagtt tgggaagggt      900

aggagcgatt ttggctgctc tgaacctgtg gcccttgagt gggaggggaa gctcatcata      960

aacacccgag ttgactggaa acgccgtctg gtgtacgagt ccagtgacat ggagaaaccg     1020

tgggtggagg ctgtcggaac cgtctcgcgt gtgtggggcc cctcaccaaa atcgaaccag     1080

cccggcagtc agagcagctt cactgccgtg accatcgaag gaatgcgtgt gatgctcttc     1140

acacacccgc tgaattttaa gggaaggtgg ctgcgcgacc gactgaacct ctggctgacg     1200

gataaccagc gcatttataa cgttgggcaa gtatccattg gtgatgaaaa ttccgcctac     1260

agctccgtcc tgtacaagga tgataagctg tactgtttgc atgagatcaa cacggacgag     1320

gtgtacagcc ttgtttttgc acgcctggtt ggcgagctac ggatcattaa atcagtgctg     1380

cggtcctgga agaattggga cagccacctg tccagcattt gcacccctgc tgatccagcc     1440

gcttcgtcgt cagagagtgg ttgtggtccc gctgtcacca cggttggtct tgttggcttt     1500

ttgtccggca acgcctccca aaacgtatgg gaggatgcgt accgctgcgt caacgcaagc     1560

acggcaaatg cggagagggt tcggaacggt ttgaagtttg cgggggttgg cggaggagcg     1620

ctttggccgg tgagccagca ggggcagaat cagcggtatc gttttgcaaa ccacgcgttc     1680

acgctggtgg cgtcggtgac gattcacgag gctccgaggg ccgcgagtcc cttgctgggt     1740

gcgagcctgg actcttctgg cggcaaaaaa ctcctggggc tctcgtacga cgagaagcac     1800

cagtggcagc caatatacgg atcaacgccg gtgacgccga cgggatcgtg ggagacgggt     1860

aaaaggtacc acttggttct tacgatggcg aataaaattg gctccgtgta cattgatgga     1920

gaacttctgg agggttcagg acagaccgtt gtgccagacg ggaggacgcc tgacatctcc     1980

cacttctacg ttggcgggta taaaaggagt gatatgccaa ccataagcca cgtgacggtg     2040

aataatgttc ttctttacaa ccgacagctg aataccgagg agatcaggac cttgttcttg     2100

agccaggacc ttattggcac ggaagcacac atg                                  2133


<210> 2
<211> 666
<212> PRT
<213> Trypanosoma cruzi

<400> 2
Met Gly Lys Thr Val Val Val Ala Ser Arg Met Phe Trp Leu Met Phe 
1               5                   10                  15      


Phe Val Pro Leu Leu Leu Ala Ile Cys Pro Ser Glu Pro Ala Tyr Ala 
            20                  25                  30          


Leu Ala Pro Gly Ser Ser Arg Val Glu Leu Phe Lys Arg Lys Asn Ser 
        35                  40                  45              


Thr Val Pro Phe Glu Asp Lys Ala Gly Lys Val Thr Glu Arg Val Val 
    50                  55                  60                  


His Ser Phe Arg Leu Pro Ala Leu Val Asn Val Asp Gly Val Met Val 
65                  70                  75                  80  


Ala Ile Ala Asp Ala Arg Tyr Asp Thr Ser Asn Asp Asn Ser Leu Ile 
                85                  90                  95      


Asp Thr Val Ala Lys Tyr Ser Val Asp Asp Gly Glu Thr Trp Glu Thr 
            100                 105                 110         


Gln Ile Ala Ile Lys Asn Ser Arg Val Ser Ser Val Ser Arg Val Val 
        115                 120                 125             


Asp Pro Thr Val Ile Val Lys Gly Asn Lys Leu Tyr Val Leu Val Gly 
    130                 135                 140                 


Ser Tyr Tyr Ser Ser Arg Ser Tyr Trp Ser Ser His Gly Asp Ala Arg 
145                 150                 155                 160 


Asp Trp Asp Ile Leu Leu Ala Val Gly Glu Val Thr Lys Ser Thr Ala 
                165                 170                 175     


Gly Gly Lys Ile Thr Ala Ser Ile Lys Trp Gly Ser Pro Val Ser Leu 
            180                 185                 190         


Lys Lys Phe Phe Pro Ala Glu Met Glu Gly Met His Thr Asn Gln Phe 
        195                 200                 205             


Leu Gly Gly Ala Gly Val Ala Ile Val Ala Ser Asn Gly Asn Leu Val 
    210                 215                 220                 


Tyr Pro Val Gln Val Thr Asn Lys Lys Lys Gln Val Phe Ser Lys Ile 
225                 230                 235                 240 


Phe Tyr Ser Glu Asp Asp Gly Lys Thr Trp Lys Phe Gly Lys Gly Arg 
                245                 250                 255     


Ser Asp Phe Gly Cys Ser Glu Pro Val Ala Leu Glu Trp Glu Gly Lys 
            260                 265                 270         


Leu Ile Ile Asn Thr Arg Val Asp Trp Lys Arg Arg Leu Val Tyr Glu 
        275                 280                 285             


Ser Ser Asp Met Glu Lys Pro Trp Val Glu Ala Val Gly Thr Val Ser 
    290                 295                 300                 


Arg Val Trp Gly Pro Ser Pro Lys Ser Asn Gln Pro Gly Ser Gln Ser 
305                 310                 315                 320 


Ser Phe Thr Ala Val Thr Ile Glu Gly Met Arg Val Met Leu Phe Thr 
                325                 330                 335     


His Pro Leu Asn Phe Lys Gly Arg Trp Leu Arg Asp Arg Leu Asn Leu 
            340                 345                 350         


Trp Leu Thr Asp Asn Gln Arg Ile Tyr Asn Val Gly Gln Val Ser Ile 
        355                 360                 365             


Gly Asp Glu Asn Ser Ala Tyr Ser Ser Val Leu Tyr Lys Asp Asp Lys 
    370                 375                 380                 


Leu Tyr Cys Leu His Glu Ile Asn Thr Asp Glu Val Tyr Ser Leu Val 
385                 390                 395                 400 


Phe Ala Arg Leu Val Gly Glu Leu Arg Ile Ile Lys Ser Val Leu Arg 
                405                 410                 415     


Ser Trp Lys Asn Trp Asp Ser His Leu Ser Ser Ile Cys Thr Pro Ala 
            420                 425                 430         


Asp Pro Ala Ala Ser Ser Ser Glu Ser Gly Cys Gly Pro Ala Val Thr 
        435                 440                 445             


Thr Val Gly Leu Val Gly Phe Leu Ser Gly Asn Ala Ser Gln Asn Val 
    450                 455                 460                 


Trp Glu Asp Ala Tyr Arg Cys Val Asn Ala Ser Thr Ala Asn Ala Glu 
465                 470                 475                 480 


Arg Val Arg Asn Gly Leu Lys Phe Ala Gly Val Gly Gly Gly Ala Leu 
                485                 490                 495     


Trp Pro Val Ser Gln Gln Gly Gln Asn Gln Arg Tyr Arg Phe Ala Asn 
            500                 505                 510         


His Ala Phe Thr Leu Val Ala Ser Val Thr Ile His Glu Ala Pro Arg 
        515                 520                 525             


Ala Ala Ser Pro Leu Leu Gly Ala Ser Leu Asp Ser Ser Gly Gly Lys 
    530                 535                 540                 


Lys Leu Leu Gly Leu Ser Tyr Asp Glu Lys His Gln Trp Gln Pro Ile 
545                 550                 555                 560 


Tyr Gly Ser Thr Pro Val Thr Pro Thr Gly Ser Trp Glu Thr Gly Lys 
                565                 570                 575     


Arg Tyr His Leu Val Leu Thr Met Ala Asn Lys Ile Gly Ser Val Tyr 
            580                 585                 590         


Ile Asp Gly Glu Leu Leu Glu Gly Ser Gly Gln Thr Val Val Pro Asp 
        595                 600                 605             


Gly Arg Thr Pro Asp Ile Ser His Phe Tyr Val Gly Gly Tyr Lys Arg 
    610                 615                 620                 


Ser Asp Met Pro Thr Ile Ser His Val Thr Val Asn Asn Val Leu Leu 
625                 630                 635                 640 


Tyr Asn Arg Gln Leu Asn Thr Glu Glu Ile Arg Thr Leu Phe Leu Ser 
                645                 650                 655     


Gln Asp Leu Ile Gly Thr Glu Ala His Met 
            660                 665     


<210> 3
<211> 5403
<212> DNA
<213> Trypanosoma cruzi

<400> 3
aaagaccgtt ggaagaagaa agaaggttcc ggagcgtggc caccaccaac gatgaactgc       60

cacaattgcg tgctgtccgc gggcggtacc cggcgctttg agcccacggc gacttgtgtg      120

ttcccctttc tcttcccact ttctccgcgg caatccccct gcaaagagac gatcttgaca      180

ccattgtttt aggcataata gaagttctac aaacaacgcc cgaaggacac acaggcaggc      240

accgactacg atggggaaaa cagtcgttgt ggccagtagg atgttctggc taatgttttt      300

cgtgccgctt cttcttgcga tctgccccag cgagcccgcg tacgccctgg cacccggatc      360

gagccgagtt gagggtttaa gcgtaagaat tcgacggtgc cgtttgaaga caaggccggc      420

aaagtcaccg agcgggttgt ccactcgttc cgcttccccg cccttgttaa tgtggacggg      480

gtgatggttg ccatcgcgga cgctcgctac gaaacatcca gtgaaaactc cctcattgat      540

acggtggcga agtacagcgt ggacgatggg gagacgtggg agacccaaat tgccatcaag      600

aacagccgtg tatcgtctgt ttctcgtgtg gtggatccca ccgtgattgt gaagggcaac      660

aagctttacg tcctggttgg aagctactat agttcgagaa gctactggtc gtcgcatggt      720

gatgcgagag actgggatat tctgcttgcc gttggtgagg tcacgaagtc cactgcgggc      780

ggcaagataa ctgcgagtat caaatggggg agccccgtgt cactgaagaa gttttttccg      840

gcagaaatgg aaggcatgca cacaaatcaa tttcttggcg gcgcgggtgt tgccattgta      900

gcgtccaacg ggaatcttgt gtaccctgtg caggttacga acaaaaggaa gcaagttttc      960

tccaagatct tctactcgga agatgatggc aagacgtgga agtttgggaa gggtaggagc     1020

gattttggct gctctgaacc tgtggccctt gagtgggagg ggaagctcat cataaacacc     1080

cgagttgact ggaaacgccg tctggtgtac gagtccagtg acatggagaa accgtgggtg     1140

gaggctgtcg gaaccgtctc gcgtgtgtgg ggcccctcac caaaatcgaa ccagcccggc     1200

agtcagacga gcttcactgc cgtgaccatc gaaggaatgc gtgtgatgct cttcacacac     1260

ccgctgaatt ttaagggaag gtgcgtgcgc gaccgactga acctctggct gacggataac     1320

cagcgcattt ataacgttgg gcaagtatcc attggtgatg aaaattccgc ctacagctcc     1380

gtcctgtaca aggatgataa gctgtactgt ttgcatgaga tcaacacgga cgaggtgtac     1440

agccttgttt ttgcacgcct ggttggcgag ctacggatca ttaaatcagt gctgcggtcc     1500

tggaagaatt ggacagccac ctgtccagca tttgcacccc tgctgatcca gccgcttcgt     1560

cgtcagagag tggttgtggt cccgctgtca ccacggttgg tcttgttggc tttttgtcgg     1620

caacgcctcc caaaacgtat gggaggatcg taccgctgcg tcaacgcaag cacggcaaat     1680

gcggagaggg ttcggaacgg tttgaagttt gcgggggttg gcggaggagc gctttggccg     1740

gtgagccagc aggggcagaa tcagcggtat cgttttgcaa accacgcgtt cacgctggtg     1800

gcgtcggtga cgattcacga ggctccgagg gccgcgagtc ccttgctggg tgcgagcctg     1860

gactcttctg gcggcaaaaa actcctgggg ctctcgtacg acgagaagca ccagtggcag     1920

ccaatatacg gatcaacgcc ggtgacgccg acgggatcgt gggagacggg taaaaggtac     1980

cacttggttc ttacgatggc gaataaaatt ggctccgtgt acattgatgg agaacttctg     2040

gagggttcag gacagaccgt tgtgccagac gggaggacgc ctgacatctc ccacttctac     2100

gttggcgggt ataaaaggag tgatatgcca accataagcc acgtgacggt gaataatgtt     2160

cttctttaca accgacgaca gctgaatacc gaggagatca ggaccttgtt cttgagccag     2220

gaccttattg gcacggaagc acacatggac agcagcagcg acagcagtgc ccacagtacg     2280

ccctcaactc ccgctgacag cagtgcccac agtacgccct caactcccgt tgacagcagt     2340

gcccacagta cgccctcgac tcccgctgac agcagtgccc acggtacgcc ctcaactccc     2400

gttgacagca gtgcccacgg tacgccctca actcccgctg acagcagtgc ccacggtacg     2460

ccctcaactc ccgttgacag cagtgcccac agtacgccct caactcccgt tgacagcagt     2520

gcccacagta cgccctcaac tcccgttgac agcagtgccc acggtgcgcc ctcaactccc     2580

gctgacagca gtgcccacgg tacgccctcg actcccgttg acagcagtgc ccacggtacg     2640

ccctcgactc ccgctgacag cagtgcccac agtacgccct cgactcccgc tgacagcagt     2700

gcccacagta cgccctcgac tcccgctgac agcagtgccc acagtacgcc ctcgactccc     2760

gttgacagca gtgcccacgg tacgccctcg actcccgctg acagcagtgc ccacagtacg     2820

ccctcgactc ccgctgacag cagtgcccac ggtacgccct caactcccgt tgacagcagt     2880

gcccacagta cgccctcgac tcccgttgac agcagtgccc acggtacgcc ctcaactccc     2940

gttgacagca gtgcccacag tacgccctcg actcccgttg acagcagtgc ccacggtacg     3000

ccctcaactc ccgttgacag cagtgcccac agtacgccct cgactcccgc tgacagcagt     3060

gcccacagta cgccctcaac tcccgctgac agcagtgccc acggtacgcc ctcaactccc     3120

gttgacagca gtgcccacag tacgccctcg actcccgctg acagcagtgc ccacagtacg     3180

ccctcaactc ccgttgacag cagtgcccac agtacgccct caactcccgc tgacagcagt     3240

gcccacggta cgccctcaac tcccgttgac agcagtgccc acggtacgcc ctcgactccc     3300

gctgacagca gtgcccacag tacgccctcg actcccgctg acagcagtgc ccacagtacg     3360

ccctcgactc ccgctgacag cagtgcccac agtacgccct caactcccgt tgacagcagt     3420

gcccacagta cgccctcaac tcccgctgac agcagtgccc acagtacgcc ctcaactccc     3480

gctgacagca gtgcccacag tacgccctcg actcccgctg acagcagtgc ccacagtacg     3540

ccctcaactc ccgttgacag cagtgcccac agtacgccct caactcccgc tgacagcagt     3600

gcccacggta cgccctcgac tcccgctgac agcagtgccc acagtacgcc ctcgactccc     3660

gttgacagca gtgcccacag tacgccctcg actcccgctg acagcagtgc ccacggtacg     3720

ccctcgactc ccgctgacag cagtgcccac agtacgccct cgactcccgc tgacagcagt     3780

gcccacggta cgccctcgac tcccgctgac agcagtgccc acagtacgcc ctcaactccc     3840

gctggcagca gcgccaatgg tacggttctg attttgcccg atggcgctgc actttcgacc     3900

ttttcgggcg gagggcttct tctgtgtgcg tgtgctttgc tgctgcacgt gttttttatg     3960

gcagttttct gatgtagtga gagagtctcc taacaaatgt agataaattc ataattgtgg     4020

tgtgaaccgt ttgggtaaat gtgtgtgtgc gctctcataa ggaaatgatt tccagtaatg     4080

tttttttttt gttctcgaac attttgaata aatctgcaga cagatgggga cgcgtaattt     4140

gaatttgttt ttcagcgttc ttttgtcact ggccccttgt ttaagtggaa ccgcgttgca     4200

atgcggcgag ggcatttctc tgttttgatt tccttctttt tctcctttgt gtttcttcaa     4260

tttgacggtt tgcacgctgt gcggtggagc gttttccctt gtgaaataag ggccaactgc     4320

ttcacagtgg cacgagggcg ctcaagagat ccgcgggtcg ccagtgactc actttgtgtg     4380

gcgcagctcg aggaggtgtc tggctgctgt gggggcctcg atggttgcca cttcgcgagt     4440

ttgcaacgag cgtgcttctc gcggagggag caggcgaaat attttgtttt ttttttttgt     4500

tttttttgtt tttttgtttt tgtgtgtgtg tgtaagtttt ggttcagtct cccttgaact     4560

gggggacgtt gggcttaatg gaccaaactc tgattcccct aaaacttctt ttgttggttt     4620

tcttttgttt ttgtttttgt gctgctgatt tgcacgcttt ctcactgtca ccgaagcgcg     4680

gcggcggtgt ttgagtgccc cctcacgctg ctgctgtgga atttgcgttg cttgcggaca     4740

tttctgttgg gtcgcattgc tttctacttc gttttttatt tttgtggttt ggtggagggg     4800

agtgtgcagc agggggcggg ccgagatgcc tgtggagaca gcgacgttgc ggggactctc     4860

tctcggcctc gtcattcaac aatccattgc gcagcaggtt gccacgaaca ccagcaccaa     4920

tatttgttcg ttttcccact attaccggcg cgtctagccg cacgatgcca tctgggtgcc     4980

gaggaggcgg ttgagcagcg gaaaaggctt cctgctatga agcgactgcc attgagagaa     5040

cttttagctg cgtggatctt cctcaatgcc cagccgttgg cgcgcagcgg aggtgcctgg     5100

gcattctagg agcagatggc gaaaggtttc ctgcgcgtca actggcgtgt ctgtggaggt     5160

tggctatcct cagtcgggag accgcctcct ggcaccacag aacgggtagc ggtagtgtct     5220

tggcgaatag tacaacgcca cttgttgctg actgggcagt aaagcatgtc agcgggtccg     5280

tgtgccatac gggcgcattc catgttccgt gtgttgtccg gttgccatgg tctgcgtcgc     5340

atgctgagcc gcaggctcgt caacatgcac tccacaatgt ccgtaagaaa actcccggtg     5400

cac                                                                   5403


<210> 4
<211> 1162
<212> PRT
<213> Trypanosoma cruzi

<400> 4
Met Val Ala Ile Ala Asp Ala Arg Tyr Glu Thr Ser Ser Glu Asn Ser 
1               5                   10                  15      


Leu Ile Asp Thr Val Ala Lys Tyr Ser Val Asp Asp Gly Glu Thr Trp 
            20                  25                  30          


Glu Thr Gln Ile Ala Ile Lys Asn Ser Arg Val Ser Ser Val Ser Arg 
        35                  40                  45              


Val Val Asp Pro Thr Val Ile Val Lys Gly Asn Lys Leu Tyr Val Leu 
    50                  55                  60                  


Val Gly Ser Tyr Tyr Ser Ser Arg Ser Tyr Trp Ser Ser His Gly Asp 
65                  70                  75                  80  


Ala Arg Asp Trp Asp Ile Leu Leu Ala Val Gly Glu Val Thr Lys Ser 
                85                  90                  95      


Thr Ala Gly Gly Lys Ile Thr Ala Ser Ile Lys Trp Gly Ser Pro Val 
            100                 105                 110         


Ser Leu Lys Lys Phe Phe Pro Ala Glu Met Glu Gly Met His Thr Asn 
        115                 120                 125             


Gln Phe Leu Gly Gly Ala Gly Val Ala Ile Val Ala Ser Asn Gly Asn 
    130                 135                 140                 


Leu Val Tyr Pro Val Gln Val Thr Asn Lys Arg Lys Gln Val Phe Ser 
145                 150                 155                 160 


Lys Ile Phe Tyr Ser Glu Asp Asp Gly Lys Thr Trp Lys Phe Gly Lys 
                165                 170                 175     


Gly Arg Ser Asp Phe Gly Cys Ser Glu Pro Val Ala Leu Glu Trp Glu 
            180                 185                 190         


Gly Lys Leu Ile Ile Asn Thr Arg Val Asp Trp Lys Arg Arg Leu Val 
        195                 200                 205             


Tyr Glu Ser Ser Asp Met Glu Lys Pro Trp Val Glu Ala Val Gly Thr 
    210                 215                 220                 


Val Ser Arg Val Trp Gly Pro Ser Pro Lys Ser Asn Gln Pro Gly Ser 
225                 230                 235                 240 


Gln Thr Ser Phe Thr Ala Val Thr Ile Glu Gly Met Arg Val Met Leu 
                245                 250                 255     


Phe Thr His Pro Leu Asn Phe Lys Gly Arg Cys Val Arg Asp Arg Leu 
            260                 265                 270         


Asn Leu Trp Leu Thr Asp Asn Gln Arg Ile Tyr Asn Val Gly Gln Val 
        275                 280                 285             


Ser Ile Gly Asp Glu Asn Ser Ala Tyr Ser Ser Val Leu Tyr Lys Asp 
    290                 295                 300                 


Asp Lys Leu Tyr Cys Leu His Glu Ile Asn Thr Asp Glu Val Tyr Ser 
305                 310                 315                 320 


Leu Val Phe Ala Arg Leu Val Gly Glu Leu Arg Ile Ile Lys Ser Val 
                325                 330                 335     


Leu Arg Ser Trp Lys Asn Trp Thr Ala Thr Cys Pro Ala Phe Ala Pro 
            340                 345                 350         


Leu Leu Ile Gln Pro Leu Arg Arg Gln Arg Val Val Val Val Pro Leu 
        355                 360                 365             


Ser Pro Arg Leu Val Leu Leu Ala Phe Cys Arg Gln Arg Leu Pro Lys 
    370                 375                 380                 


Arg Met Gly Gly Ser Tyr Arg Cys Val Asn Ala Ser Thr Ala Asn Ala 
385                 390                 395                 400 


Glu Arg Val Arg Asn Gly Leu Lys Phe Ala Gly Val Gly Gly Gly Ala 
                405                 410                 415     


Leu Trp Pro Val Ser Gln Gln Gly Gln Asn Gln Arg Tyr Arg Phe Ala 
            420                 425                 430         


Asn His Ala Phe Thr Leu Val Ala Ser Val Thr Ile His Glu Ala Pro 
        435                 440                 445             


Arg Ala Ala Ser Pro Leu Leu Gly Ala Ser Leu Asp Ser Ser Gly Gly 
    450                 455                 460                 


Lys Lys Leu Leu Gly Leu Ser Tyr Asp Glu Lys His Gln Trp Gln Pro 
465                 470                 475                 480 


Ile Tyr Gly Ser Thr Pro Val Thr Pro Thr Gly Ser Trp Glu Thr Gly 
                485                 490                 495     


Lys Arg Tyr His Leu Val Leu Thr Met Ala Asn Lys Ile Gly Ser Val 
            500                 505                 510         


Tyr Ile Asp Gly Glu Leu Leu Glu Gly Ser Gly Gln Thr Val Val Pro 
        515                 520                 525             


Asp Gly Arg Thr Pro Asp Ile Ser His Phe Tyr Val Gly Gly Tyr Lys 
    530                 535                 540                 


Arg Ser Asp Met Pro Thr Ile Ser His Val Thr Val Asn Asn Val Leu 
545                 550                 555                 560 


Leu Tyr Asn Arg Arg Gln Leu Asn Thr Glu Glu Ile Arg Thr Leu Phe 
                565                 570                 575     


Leu Ser Gln Asp Leu Ile Gly Thr Glu Ala His Met Asp Ser Ser Ser 
            580                 585                 590         


Asp Ser Ser Ala His Ser Thr Pro Ser Thr Pro Ala Asp Ser Ser Ala 
        595                 600                 605             


His Ser Thr Pro Ser Thr Pro Val Asp Ser Ser Ala His Ser Thr Pro 
    610                 615                 620                 


Ser Thr Pro Ala Asp Ser Ser Ala His Gly Thr Pro Ser Thr Pro Val 
625                 630                 635                 640 


Asp Ser Ser Ala His Gly Thr Pro Ser Thr Pro Ala Asp Ser Ser Ala 
                645                 650                 655     


His Gly Thr Pro Ser Thr Pro Val Asp Ser Ser Ala His Ser Thr Pro 
            660                 665                 670         


Ser Thr Pro Val Asp Ser Ser Ala His Ser Thr Pro Ser Thr Pro Val 
        675                 680                 685             


Asp Ser Ser Ala His Gly Ala Pro Ser Thr Pro Ala Asp Ser Ser Ala 
    690                 695                 700                 


His Gly Thr Pro Ser Thr Pro Val Asp Ser Ser Ala His Gly Thr Pro 
705                 710                 715                 720 


Ser Thr Pro Ala Asp Ser Ser Ala His Ser Thr Pro Ser Thr Pro Ala 
                725                 730                 735     


Asp Ser Ser Ala His Ser Thr Pro Ser Thr Pro Ala Asp Ser Ser Ala 
            740                 745                 750         


His Ser Thr Pro Ser Thr Pro Val Asp Ser Ser Ala His Gly Thr Pro 
        755                 760                 765             


Ser Thr Pro Ala Asp Ser Ser Ala His Ser Thr Pro Ser Thr Pro Ala 
    770                 775                 780                 


Asp Ser Ser Ala His Gly Thr Pro Ser Thr Pro Val Asp Ser Ser Ala 
785                 790                 795                 800 


His Ser Thr Pro Ser Thr Pro Val Asp Ser Ser Ala His Gly Thr Pro 
                805                 810                 815     


Ser Thr Pro Val Asp Ser Ser Ala His Ser Thr Pro Ser Thr Pro Val 
            820                 825                 830         


Asp Ser Ser Ala His Gly Thr Pro Ser Thr Pro Val Asp Ser Ser Ala 
        835                 840                 845             


His Ser Thr Pro Ser Thr Pro Ala Asp Ser Ser Ala His Ser Thr Pro 
    850                 855                 860                 


Ser Thr Pro Ala Asp Ser Ser Ala His Gly Thr Pro Ser Thr Pro Val 
865                 870                 875                 880 


Asp Ser Ser Ala His Ser Thr Pro Ser Thr Pro Ala Asp Ser Ser Ala 
                885                 890                 895     


His Ser Thr Pro Ser Thr Pro Val Asp Ser Ser Ala His Ser Thr Pro 
            900                 905                 910         


Ser Thr Pro Ala Asp Ser Ser Ala His Gly Thr Pro Ser Thr Pro Val 
        915                 920                 925             


Asp Ser Ser Ala His Gly Thr Pro Ser Thr Pro Ala Asp Ser Ser Ala 
    930                 935                 940                 


His Ser Thr Pro Ser Thr Pro Ala Asp Ser Ser Ala His Ser Thr Pro 
945                 950                 955                 960 


Ser Thr Pro Ala Asp Ser Ser Ala His Ser Thr Pro Ser Thr Pro Val 
                965                 970                 975     


Asp Ser Ser Ala His Ser Thr Pro Ser Thr Pro Ala Asp Ser Ser Ala 
            980                 985                 990         


His Ser Thr Pro Ser Thr Pro Ala  Asp Ser Ser Ala His  Ser Thr Pro 
        995                 1000                 1005             


Ser Thr  Pro Ala Asp Ser Ser  Ala His Ser Thr Pro  Ser Thr Pro 
    1010                 1015                 1020             


Val Asp  Ser Ser Ala His Ser  Thr Pro Ser Thr Pro  Ala Asp Ser 
    1025                 1030                 1035             


Ser Ala  His Gly Thr Pro Ser  Thr Pro Ala Asp Ser  Ser Ala His 
    1040                 1045                 1050             


Ser Thr  Pro Ser Thr Pro Val  Asp Ser Ser Ala His  Ser Thr Pro 
    1055                 1060                 1065             


Ser Thr  Pro Ala Asp Ser Ser  Ala His Gly Thr Pro  Ser Thr Pro 
    1070                 1075                 1080             


Ala Asp  Ser Ser Ala His Ser  Thr Pro Ser Thr Pro  Ala Asp Ser 
    1085                 1090                 1095             


Ser Ala  His Gly Thr Pro Ser  Thr Pro Ala Asp Ser  Ser Ala His 
    1100                 1105                 1110             


Ser Thr  Pro Ser Thr Pro Ala  Gly Ser Ser Ala Asn  Gly Thr Val 
    1115                 1120                 1125             


Leu Ile  Leu Pro Asp Gly Ala  Ala Leu Ser Thr Phe  Ser Gly Gly 
    1130                 1135                 1140             


Gly Leu  Leu Leu Cys Ala Cys  Ala Leu Leu Leu His  Val Phe Phe 
    1145                 1150                 1155             


Met Ala  Val Phe 
    1160         


<210> 5
<211> 588
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Gly Lys Thr Val Val Val Ala Ser Arg Met Phe Trp Leu Met Phe 
1               5                   10                  15      


Phe Val Pro Leu Leu Leu Ala Ile Cys Pro Ser Glu Pro Ala Tyr Ala 
            20                  25                  30          


Leu Ala Pro Gly Ser Ser Arg Val Glu Leu Phe Lys Arg Lys Asn Ser 
        35                  40                  45              


Thr Val Pro Phe Glu Asp Lys Ala Gly Lys Val Thr Glu Arg Val Val 
    50                  55                  60                  


His Ser Phe Arg Leu Pro Ala Leu Val Asn Val Asp Gly Val Met Val 
65                  70                  75                  80  


Ala Ile Ala Asp Ala Arg Tyr Asp Thr Ser Asn Asp Asn Ser Leu Ile 
                85                  90                  95      


Asp Thr Val Ala Lys Tyr Ser Val Asp Asp Gly Glu Thr Trp Glu Thr 
            100                 105                 110         


Gln Ile Ala Ile Lys Asn Ser Arg Val Ser Ser Val Ser Arg Val Val 
        115                 120                 125             


Asp Pro Thr Val Ile Val Lys Gly Asn Lys Leu Tyr Val Leu Val Gly 
    130                 135                 140                 


Ser Tyr Tyr Ser Ser Arg Ser Tyr Trp Ser Ser His Gly Asp Ala Arg 
145                 150                 155                 160 


Asp Trp Asp Ile Leu Leu Ala Val Gly Glu Val Thr Lys Ser Thr Ala 
                165                 170                 175     


Gly Gly Lys Ile Thr Ala Ser Ile Lys Trp Gly Ser Pro Val Ser Leu 
            180                 185                 190         


Lys Lys Phe Phe Pro Ala Glu Met Glu Gly Met His Thr Asn Gln Phe 
        195                 200                 205             


Leu Gly Gly Ala Gly Val Ala Ile Val Ala Ser Asn Gly Asn Leu Val 
    210                 215                 220                 


Tyr Pro Val Gln Val Thr Asn Lys Lys Lys Gln Val Phe Ser Lys Ile 
225                 230                 235                 240 


Phe Tyr Ser Glu Asp Asp Gly Lys Thr Trp Lys Phe Gly Lys Gly Arg 
                245                 250                 255     


Ser Asp Phe Gly Cys Ser Glu Pro Val Ala Leu Glu Trp Glu Gly Lys 
            260                 265                 270         


Leu Ile Ile Asn Thr Arg Val Asp Trp Lys Arg Arg Leu Val Tyr Glu 
        275                 280                 285             


Ser Ser Asp Met Glu Lys Pro Trp Val Glu Ala Val Gly Thr Val Ser 
    290                 295                 300                 


Arg Val Trp Gly Pro Ser Pro Lys Ser Asn Gln Pro Gly Ser Gln Ser 
305                 310                 315                 320 


Ser Phe Thr Ala Val Thr Ile Glu Gly Met Arg Val Met Leu Phe Thr 
                325                 330                 335     


His Pro Leu Asn Phe Lys Gly Arg Trp Leu Arg Asp Arg Leu Asn Leu 
            340                 345                 350         


Trp Leu Thr Asp Asn Gln Arg Ile Tyr Asn Val Gly Gln Val Ser Ile 
        355                 360                 365             


Gly Asp Glu Asn Ser Ala Tyr Ser Ser Val Leu Tyr Lys Asp Asp Lys 
    370                 375                 380                 


Leu Tyr Cys Leu His Glu Ile Asn Thr Asp Glu Val Tyr Ser Leu Val 
385                 390                 395                 400 


Phe Ala Arg Leu Val Gly Glu Leu Arg Ile Ile Lys Ser Val Leu Arg 
                405                 410                 415     


Ser Trp Lys Asn Trp Asp Ser His Leu Ser Ser Ile Cys Thr Pro Ala 
            420                 425                 430         


Asp Pro Ala Ala Ser Ser Ser Glu Ser Gly Cys Gly Pro Ala Val Thr 
        435                 440                 445             


Thr Val Gly Leu Val Gly Phe Leu Ser Gly Asn Ala Ser Gln Asn Val 
    450                 455                 460                 


Trp Glu Asp Ala Tyr Arg Cys Val Asn Ala Ser Thr Ala Asn Ala Glu 
465                 470                 475                 480 


Arg Val Arg Asn Gly Leu Lys Phe Ala Gly Val Gly Gly Gly Ala Leu 
                485                 490                 495     


Trp Pro Val Ser Gln Gln Gly Gln Asn Gln Arg Tyr Arg Phe Ala Asn 
            500                 505                 510         


His Ala Phe Thr Leu Val Ala Ser Val Thr Ile His Glu Ala Pro Arg 
        515                 520                 525             


Ala Ala Ser Pro Leu Leu Gly Ala Ser Leu Asp Ser Ser Gly Gly Lys 
    530                 535                 540                 


Lys Leu Leu Gly Leu Ser Tyr Asp Glu Lys His Gln Trp Gln Pro Ile 
545                 550                 555                 560 


Tyr Gly Ser Thr Pro Val Thr Pro Thr Gly Ser Trp Glu Thr Gly Lys 
                565                 570                 575     


Arg Tyr His Leu Val Leu Thr Met Ala Asn Lys Ile 
            580                 585             


<210> 6
<211> 1764
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
atggggaaaa cagtcgttgt ggccagtagg atgttctggc taatgttttt cgtgccgctt       60

cttcttgcga tctgccccag cgagcccgcg tacgccttgg cacccggatc gagccgagtt      120

gagctgttta agcgtaagaa ttcgacggtg ccgtttgaag acaaggccgg caaagtcacc      180

gagcgggttg tccactcgtt ccgcctcccc gcccttgtta atgtggacgg ggtgatggtt      240

gccatcgcgg acgctcgcta cgacacatcc aatgacaact ccctcattga tacggtggcg      300

aagtacagcg tggacgatgg ggagacgtgg gagacccaaa ttgccatcaa gaacagccgt      360

gtatcgtctg tttctcgtgt ggtggatccc accgtgattg tgaagggcaa caagctttac      420

gtcctggttg gaagctacta tagttcgaga agctactggt cgtcgcatgg tgatgcgaga      480

gactgggata ttctgcttgc cgttggtgag gtcacgaagt ccactgcggg cggcaagata      540

actgcgagta tcaaatgggg gagccccgtg tcactgaaga agttttttcc ggcagaaatg      600

gaaggcatgc acacaaatca atttcttggc ggcgcgggtg ttgccattgt agcgtccaac      660

gggaatcttg tgtaccctgt gcaggttacg aacaaaaaga agcaagtttt ctccaagatc      720

ttctactcgg aagatgatgg caagacgtgg aagtttggga agggtaggag cgattttggc      780

tgctctgaac ctgtggccct tgagtgggag gggaagctca tcataaacac ccgagttgac      840

tggaaacgcc gtctggtgta cgagtccagt gacatggaga aaccgtgggt ggaggctgtc      900

ggaaccgtct cgcgtgtgtg gggcccctca ccaaaatcga accagcccgg cagtcagagc      960

agcttcactg ccgtgaccat cgaaggaatg cgtgtgatgc tcttcacaca cccgctgaat     1020

tttaagggaa ggtggctgcg cgaccgactg aacctctggc tgacggataa ccagcgcatt     1080

tataacgttg ggcaagtatc cattggtgat gaaaattccg cctacagctc cgtcctgtac     1140

aaggatgata agctgtactg tttgcatgag atcaacacgg acgaggtgta cagccttgtt     1200

tttgcacgcc tggttggcga gctacggatc attaaatcag tgctgcggtc ctggaagaat     1260

tgggacagcc acctgtccag catttgcacc cctgctgatc cagccgcttc gtcgtcagag     1320

agtggttgtg gtcccgctgt caccacggtt ggtcttgttg gctttttgtc cggcaacgcc     1380

tcccaaaacg tatgggagga tgcgtaccgc tgcgtcaacg caagcacggc aaatgcggag     1440

agggttcgga acggtttgaa gtttgcgggg gttggcggag gagcgctttg gccggtgagc     1500

cagcaggggc agaatcagcg gtatcgtttt gcaaaccacg cgttcacgct ggtggcgtcg     1560

gtgacgattc acgaggctcc gagggccgcg agtcccttgc tgggtgcgag cctggactct     1620

tctggcggca aaaaactcct ggggctctcg tacgacgaga agcaccagtg gcagccaata     1680

tacggatcaa cgccggtgac gccgacggga tcgtgggaga cgggtaaaag gtaccacttg     1740

gttcttacga tggcgaataa aatt                                            1764


<210> 7
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
tctcttcctc caccactatg ca                                                22


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
ggctgagaca gcacgtggat                                                   20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
gcccgccgaa ttcctgcact                                                   20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
caatggcacg cttgccgcag                                                   20


<210> 11
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
aatgagaaga agaggcacag ggct                                              24


<210> 12
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
atggcctggt ctaagtgctt gtca                                              24


<210> 13
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
cgacattgtg gcctttggaa ccat                                              24


<210> 14
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
agatgtcagt gatgctcttg ggct                                              24


<210> 15
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
cagcgtcgtg attagcgatg atg                                               23


<210> 16
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
cgagcaagtc tttcagtcct gtc                                               23


