                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
 
<120>  TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH 
       DYSREGULATION OF MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1 (MTORC1)

<130>  S11-397

<150>  61/785,747
<151>  2013-03-14

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  1200
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaggcccg agcgtccccg gccgcgcggc agcgcccccg gcccgatgga gaccccgccg       60

tgggacccag cccgcaacga ctcgctgccg cccacgctga ccccggccgt gcccccctac      120

gtgaagcttg gcctcaccgt cgtctacacc gtgttctacg cgctgctctt cgtgttcatc      180

tacgtgcagc tctggctggt gctgcgttac cgccacaagc ggctcagcta ccagagcgtc      240

ttcctctttc tctgcctctt ctgggcctcc ctgcggaccg tcctcttctc cttctacttc      300

aaagacttcg tggcggccaa ttcgctcagc cccttcgtct tctggctgct ctactgcttc      360

cctgtgtgcc tgcagttttt caccctcacg ctgatgaact tgtacttcac gcaggtgatt      420

ttcaaagcca agtcaaaata ttctccagaa ttactcaaat accggttgcc cctctacctg      480

gcctccctct tcatcagcct tgttttcctg ttggtgaatt taacctgtgc tgtgctggta      540

aagacgggaa attgggagag gaaggttatc gtctctgtgc gagtggccat taatgacacg      600

ctcttcgtgc tgtgtgccgt ctctctctcc atctgtctct acaaaatctc taagatgtcc      660

ttagccaaca tttacttgga gtccaagggc tcctccgtgt gtcaagtgac tgccatcggt      720

gtcaccgtga tactgcttta cacctctcgg gcctgctaca acctgttcat cctgtcattt      780

tctcagaaca agagcgtcca ttcctttgat tatgactggt acaatgtatc agaccaggca      840

gatttgaaga atcagctggg agatgctgga tacgtattat ttggagtggt gttatttgtt      900

tgggaactct tacctaccac cttagtcgtt tatttcttcc gagttagaaa tcctacaaag      960

gaccttacca accctggaat ggtccccagc catggattca gtcccagatc ttatttcttt     1020

gacaaccctc gaagatatga cagtgatgat gaccttgcct ggaacattgc ccctcaggga     1080

cttcagggag gttttgctcc agattactat gattggggac aacaaactaa cagcttcctg     1140

gcacaagcag gaactttgca agactcaact ttggatcctg acaaaccaag ccttgggtag     1200


<210>  2
<211>  755
<212>  DNA
<213>  Homo sapiens

<400>  2
catcagttaa cagttttatg gacgattcct cagatgaaaa gcttcagaaa agcatagtga       60

cagctgaatt tttagggcac ttttccttaa gaaatagaac ttgattttta tttgttacag      120

gtttccaatg gccccatagg aataagcaat aatgtagact gataaaccct tattttagta      180

ctaaagaggg agccttgcta tttcagtggg tataatttaa actttttaaa gaaaatctgt      240

acttttataa agatgtattt tgtataactt aaataataat gctaaagtat actagggttt      300

ttttttcttg agaatgttac tgcaatcatg ttgtagtttg cacagacttt tatgcataat      360

tcactttaaa aatatagaat atatggtcta atagtttttt aaagcttttg gactaaagta      420

ttccacaaat cttacctctt taggtcactg atggtcactc cgattctgag tgccacattg      480

gtagactcct aaaatacagt tgacaactta gccaattgca actccagtgt tgataattaa      540

aatgaaatgg taaagcagca gactgtaagg tctttagaga tttttttttt aaggttcagg      600

ccgtaggttc ctcaaggaat ctcttaagtt ttgcccaaag actggtactt cctttcagta      660

gggcgctaat gtatacacat taatgataag ttgataacat taaaaatgta gctgacttat      720

cctattaaac ctcctctgct atgttcacag aaaaa                                 755


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  GPR137B siRNA #1

<400>  3
ggacuaaagu auuccacaa                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  GPR137B siRNA #2

<400>  4
gcaauaaugu agacugaua                                                    19


<210>  5
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Pro Glu Arg Pro Arg Pro Arg Gly Ser Ala Pro Gly Pro Met 
1               5                   10                  15      


Glu Thr Pro Pro Trp Asp Pro Ala Arg Asn Asp Ser Leu Pro Pro Thr 
            20                  25                  30          


Leu Thr Pro Ala Val Pro Pro Tyr Val Lys Leu Gly Leu Thr Val Val 
        35                  40                  45              


Tyr Thr Val Phe Tyr Ala Leu Leu Phe Val Phe Ile Tyr Val Gln Leu 
    50                  55                  60                  


Trp Leu Val Leu Arg Tyr Arg His Lys Arg Leu Ser Tyr Gln Ser Val 
65                  70                  75                  80  


Phe Leu Phe Leu Cys Leu Phe Trp Ala Ser Leu Arg Thr Val Leu Phe 
                85                  90                  95      


Ser Phe Tyr Phe Lys Asp Phe Val Ala Ala Asn Ser Leu Ser Pro Phe 
            100                 105                 110         


Val Phe Trp Leu Leu Tyr Cys Phe Pro Val Cys Leu Gln Phe Phe Thr 
        115                 120                 125             


Leu Thr Leu Met Asn Leu Tyr Phe Thr Gln Val Ile Phe Lys Ala Lys 
    130                 135                 140                 


Ser Lys Tyr Ser Pro Glu Leu Leu Lys Tyr Arg Leu Pro Leu Tyr Leu 
145                 150                 155                 160 


Ala Ser Leu Phe Ile Ser Leu Val Phe Leu Leu Val Asn Leu Thr Cys 
                165                 170                 175     


Ala Val Leu Val Lys Thr Gly Asn Trp Glu Arg Lys Val Ile Val Ser 
            180                 185                 190         


Val Arg Val Ala Ile Asn Asp Thr Leu Phe Val Leu Cys Ala Val Ser 
        195                 200                 205             


Leu Ser Ile Cys Leu Tyr Lys Ile Ser Lys Met Ser Leu Ala Asn Ile 
    210                 215                 220                 


Tyr Leu Glu Ser Lys Gly Ser Ser Val Cys Gln Val Thr Ala Ile Gly 
225                 230                 235                 240 


Val Thr Val Ile Leu Leu Tyr Thr Ser Arg Ala Cys Tyr Asn Leu Phe 
                245                 250                 255     


Ile Leu Ser Phe Ser Gln Asn Lys Ser Val His Ser Phe Asp Tyr Asp 
            260                 265                 270         


Trp Tyr Asn Val Ser Asp Gln Ala Asp Leu Lys Asn Gln Leu Gly Asp 
        275                 280                 285             


Ala Gly Tyr Val Leu Phe Gly Val Val Leu Phe Val Trp Glu Leu Leu 
    290                 295                 300                 


Pro Thr Thr Leu Val Val Tyr Phe Phe Arg Val Arg Asn Pro Thr Lys 
305                 310                 315                 320 


Asp Leu Thr Asn Pro Gly Met Val Pro Ser His Gly Phe Ser Pro Arg 
                325                 330                 335     


Ser Tyr Phe Phe Asp Asn Pro Arg Arg Tyr Asp Ser Asp Asp Asp Leu 
            340                 345                 350         


Ala Trp Asn Ile Ala Pro Gln Gly Leu Gln Gly Gly Phe Ala Pro Asp 
        355                 360                 365             


Tyr Tyr Asp Trp Gly Gln Gln Thr Asn Ser Phe Leu Ala Gln Ala Gly 
    370                 375                 380                 


Thr Leu Gln Asp Ser Thr Leu Asp Pro Asp Lys Pro Ser Leu Gly 
385                 390                 395                 


<210>  6
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Trp Ala Val Arg Thr Arg Cys Tyr Val Val Lys Ala Gln Leu 
1               5                   10                  15      


Gly Pro Thr Val Ala Leu Glu Gly Arg Ala Pro Arg Ala Pro Gly Pro 
            20                  25                  30          


Ser Cys Leu Gly Asn Gly Asn Cys Gln Arg Pro Gly Pro Ile Thr Ser 
        35                  40                  45              


Arg Asn Val Thr Arg Ala Ser Leu Pro Asp Met Glu Ser Asn Leu Ser 
    50                  55                  60                  


Gly Leu Val Pro Ala Ala Gly Leu Val Pro Ala Leu Pro Pro Ala Val 
65                  70                  75                  80  


Thr Leu Gly Leu Thr Ala Ala Tyr Thr Thr Leu Tyr Ala Leu Leu Phe 
                85                  90                  95      


Phe Ser Val Tyr Ala Gln Leu Trp Leu Val Leu Leu Tyr Gly His Lys 
            100                 105                 110         


Arg Leu Ser Tyr Gln Thr Val Phe Leu Ala Leu Cys Leu Leu Trp Ala 
        115                 120                 125             


Ala Leu Arg Thr Thr Leu Phe Ser Phe Tyr Phe Arg Asp Thr Pro Arg 
    130                 135                 140                 


Ala Asn Arg Leu Gly Pro Leu Pro Phe Trp Leu Leu Tyr Cys Cys Pro 
145                 150                 155                 160 


Val Cys Leu Gln Phe Phe Thr Leu Thr Leu Met Asn Leu Tyr Phe Ala 
                165                 170                 175     


Gln Val Val Phe Lys Ala Lys Val Lys Arg Arg Pro Glu Met Ser Arg 
            180                 185                 190         


Gly Leu Leu Ala Val Arg Gly Ala Phe Val Gly Ala Ser Leu Leu Phe 
        195                 200                 205             


Leu Leu Val Asn Val Leu Cys Ala Val Leu Ser His Arg Arg Arg Ala 
    210                 215                 220                 


Gln Pro Trp Ala Leu Leu Leu Val Arg Val Leu Val Ser Asp Ser Leu 
225                 230                 235                 240 


Phe Val Ile Cys Ala Leu Ser Leu Ala Ala Cys Leu Cys Leu Val Ala 
                245                 250                 255     


Arg Arg Ala Pro Ser Thr Ser Ile Tyr Leu Glu Ala Lys Gly Thr Ser 
            260                 265                 270         


Val Cys Gln Ala Ala Ala Met Gly Gly Ala Met Val Leu Leu Tyr Ala 
        275                 280                 285             


Ser Arg Ala Cys Tyr Asn Leu Thr Ala Leu Ala Leu Ala Pro Gln Ser 
    290                 295                 300                 


Arg Leu Asp Thr Phe Asp Tyr Asp Trp Tyr Asn Val Ser Asp Gln Ala 
305                 310                 315                 320 


Asp Leu Val Asn Asp Leu Gly Asn Lys Gly Tyr Leu Val Phe Gly Leu 
                325                 330                 335     


Ile Leu Phe Val Trp Glu Leu Leu Pro Thr Thr Leu Leu Val Gly Phe 
            340                 345                 350         


Phe Arg Val His Arg Pro Pro Gln Asp Leu Ser Thr Ser His Ile Leu 
        355                 360                 365             


Asn Gly Gln Val Phe Ala Ser Arg Ser Tyr Phe Phe Asp Arg Ala Gly 
    370                 375                 380                 


His Cys Glu Asp Glu Gly Cys Ser Trp Glu His Ser Arg Gly Glu Ser 
385                 390                 395                 400 


Thr Arg Cys Gln Asp Gln Ala Ala Thr Thr Thr Val Ser Thr Pro Pro 
                405                 410                 415     


His Arg Arg Asp Pro Pro Pro Ser Pro Thr Glu Tyr Pro Gly Pro Ser 
            420                 425                 430         


Pro Pro His Pro Arg Pro Leu Cys Gln Val Cys Leu Pro Leu Leu Ala 
        435                 440                 445             


Gln Asp Pro Gly Gly Arg Gly Tyr Pro Leu Leu Trp Pro Ala Pro Cys 
    450                 455                 460                 


Cys Ser Cys His Ser Glu Leu Val Pro Ser Pro 
465                 470                 475 


<210>  7
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Val Ser Val Pro Gly Pro Ala Ala Ala Ala Ala Pro Ala Ala 
1               5                   10                  15      


Gly Arg Glu Pro Ser Thr Pro Gly Gly Gly Ser Gly Gly Gly Gly Ala 
            20                  25                  30          


Val Ala Ala Ala Ser Gly Ala Ala Val Pro Gly Ser Val Gln Leu Ala 
        35                  40                  45              


Leu Ser Val Leu His Ala Leu Leu Tyr Ala Ala Leu Phe Ala Phe Ala 
    50                  55                  60                  


Tyr Leu Gln Leu Trp Arg Leu Leu Leu Tyr Arg Glu Arg Arg Leu Ser 
65                  70                  75                  80  


Tyr Gln Ser Leu Cys Leu Phe Leu Cys Leu Leu Trp Ala Ala Leu Arg 
                85                  90                  95      


Thr Thr Leu Phe Ser Ala Ala Phe Ser Leu Ser Gly Ser Leu Pro Leu 
            100                 105                 110         


Leu Arg Pro Pro Ala His Leu His Phe Phe Pro His Trp Leu Leu Tyr 
        115                 120                 125             


Cys Phe Pro Ser Cys Leu Gln Phe Ser Thr Leu Cys Leu Leu Asn Leu 
    130                 135                 140                 


Tyr Leu Ala Glu Val Ile Cys Lys Val Arg Cys Ala Thr Glu Leu Asp 
145                 150                 155                 160 


Arg His Lys Ile Leu Leu His Leu Gly Phe Ile Met Ala Ser Leu Leu 
                165                 170                 175     


Phe Leu Val Val Asn Leu Thr Cys Ala Met Leu Val His Gly Asp Val 
            180                 185                 190         


Pro Glu Asn Gln Leu Lys Trp Thr Val Phe Val Arg Ala Leu Ile Asn 
        195                 200                 205             


Asp Ser Leu Phe Ile Leu Cys Ala Ile Ser Leu Val Cys Tyr Ile Cys 
    210                 215                 220                 


Lys Ile Thr Lys Met Ser Ser Ala Asn Val Tyr Leu Glu Ser Lys Gly 
225                 230                 235                 240 


Met Ser Leu Cys Gln Thr Val Val Val Gly Ser Val Val Ile Leu Leu 
                245                 250                 255     


Tyr Ser Ser Arg Ala Cys Tyr Asn Leu Val Val Val Thr Ile Ser Gln 
            260                 265                 270         


Asp Thr Leu Glu Ser Pro Phe Asn Tyr Gly Trp Asp Asn Leu Ser Asp 
        275                 280                 285             


Lys Ala His Val Glu Asp Ile Ser Gly Glu Glu Tyr Ile Val Phe Gly 
    290                 295                 300                 


Met Val Leu Phe Leu Trp Glu His Val Pro Ala Trp Ser Val Val Leu 
305                 310                 315                 320 


Phe Phe Arg Ala Gln Arg Leu Asn Gln Asn Leu Ala Pro Ala Gly Met 
                325                 330                 335     


Ile Asn Ser His Ser Tyr Ser Ser Arg Ala Tyr Phe Phe Asp Asn Pro 
            340                 345                 350         


Arg Arg Tyr Asp Ser Asp Asp Asp Leu Pro Arg Leu Gly Ser Ser Arg 
        355                 360                 365             


Glu Gly Ser Leu Pro Asn Ser Gln Ser Leu Gly Trp Tyr Gly Thr Met 
    370                 375                 380                 


Thr Gly Cys Gly Ser Ser Ser Tyr Thr Val Thr Pro His Leu Asn Gly 
385                 390                 395                 400 


Pro Met Thr Asp Thr Ala Pro Leu Leu Phe Thr Cys Ser Asn Leu Asp 
                405                 410                 415     


Leu Asn Asn His His Ser Leu Tyr Val Thr Pro Gln Asn 
            420                 425                 


