                         SEQUENCE LISTING

<110>  ALDER BIOPHARMACEUTICALS, INC.
       Dutzar, Benjamin H.
       Anderson, Katie 
       Kovacevich, Brian R.
       Feldhaus, Andrew L.
       Latham, John A.
       Garcia-Martinez, Leon F. 

 
<120>  ANTIBODIES TO HGF AND COMPOSITIONS CONTAINING

<130>  43257.4013

<140>  2014-03-14

<150>  61/782868
<151>  2013-03-14

<150>  61/781643
<151>  2013-03-14

<160>  1081  

<170>  PatentIn version 3.3

<210>  1
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Ala 
        35                  40                  45              


Val Ile Tyr Val Ile Gly Ala Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Arg Ile Pro 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val Tyr 
                85                  90                  95      


Asp Ser Val Trp Asn His Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  2
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  2

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Ala 
        35                  40                  45              


Val Ile Tyr Val Ile Gly Ala Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Arg Ile Pro 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val Tyr 
                85                  90                  95      


Asp Ser Val Trp Asn His Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  3

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  4
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  4

Ala Tyr Ala Met Ser 
1               5   


<210>  5
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  5

Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Ala 
1               5                   10                  


<210>  6
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  6

Val Ile Tyr Val Ile Gly Ala Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  7
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  7

Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Arg Ile Pro 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  8
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  8

Val Tyr Asp Ser Val Trp Asn His Phe Asn Leu 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  9

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  10
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  11
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  11
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagtgcc tatgcaatga gctgggtccg ccaggctcca    120

gagaaggggc tggagtggat cgcagtcatt tatgttattg gtgccactga ctacgcgagc    180

tgggcgaaag gccgattcac catctccaga acctcgacca cggtggatct gagaatcccc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagtttatga ttctgtctgg    300

aatcacttta acttgtgggg cccgggcacc ctggtcaccg tctcgagcgc ctccaccaag    360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc    420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc    480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc    540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac    600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac    660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc    720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc    780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc    840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt    900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc    960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg   1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac   1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg   1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac   1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac   1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc   1320

tccctgtctc cgggtaaa                                                 1338


<210>  12
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  12
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagtgcc tatgcaatga gctgggtccg ccaggctcca    120

gagaaggggc tggagtggat cgcagtcatt tatgttattg gtgccactga ctacgcgagc    180

tgggcgaaag gccgattcac catctccaga acctcgacca cggtggatct gagaatcccc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagtttatga ttctgtctgg    300

aatcacttta acttgtgggg cccgggcacc ctggtcaccg tctcgagc                 348


<210>  13
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  13
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagt                                         87


<210>  14
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  14
gcctatgcaa tgagc                                                      15


<210>  15
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  15
tgggtccgcc aggctccaga gaaggggctg gagtggatcg ca                        42


<210>  16
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  16
gtcatttatg ttattggtgc cactgactac gcgagctggg cgaaaggc                  48


<210>  17
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  17
cgattcacca tctccagaac ctcgaccacg gtggatctga gaatccccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  18
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  18
gtttatgatt ctgtctggaa tcactttaac ttg                                  33


<210>  19
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  19
tggggcccgg gcaccctggt caccgtctcg agc                                  33


<210>  20
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  20
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  21
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  21

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  22
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  22

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  23
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  23

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  24
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  24

Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  25
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  25

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  26
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  26

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  27
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  27

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  28
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  28

Gln Gln Ala Tyr Ser Val Ser Asn Val Asp Asn Ala 
1               5                   10          


<210>  29
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  29

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  30
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  30

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  31
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  31
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggggg cacagtcacc     60

atcaagtgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca    120

gggcagcctc ccaagctcct gatctaccag gcatctaaac tggcatctgg ggtcccatcg    180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ttgtcaacag gcttatagtg ttagtaatgt tgataatgct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtgg ctgcaccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  32
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  32
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggggg cacagtcacc     60

atcaagtgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca    120

gggcagcctc ccaagctcct gatctaccag gcatctaaac tggcatctgg ggtcccatcg    180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ttgtcaacag gcttatagtg ttagtaatgt tgataatgct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  33
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  33
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggggg cacagtcacc     60

atcaagtgc                                                             69


<210>  34
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  34
caggccagtc agagcattag cagttggtta gcc                                  33


<210>  35
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  35
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctac                     45


<210>  36
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  36
caggcatcta aactggcatc t                                               21


<210>  37
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  37
ggggtcccat cgcggttcaa aggcagtgga tctgggacag agttcactct caccatcagc     60

ggcgtggagt gtgccgatgc tgccacttac tattgt                               96


<210>  38
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  38
caacaggctt atagtgttag taatgttgat aatgct                               36


<210>  39
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  39
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  40
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  40
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  41
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Val Ile Gly Ala Thr Asp Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Tyr Asp Ser Val Trp Asn His Phe Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  42
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Val Ile Gly Ala Thr Asp Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Tyr Asp Ser Val Trp Asn His Phe Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  43
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  44
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  44

Ala Tyr Ala Met Ser 
1               5   


<210>  45
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  45

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  46
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  46

Val Ile Tyr Val Ile Gly Ala Thr Asp Tyr Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  47
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  47

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  48
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  48

Val Tyr Asp Ser Val Trp Asn His Phe Asn Leu 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  49

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  50
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  50

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  51
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  51
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt gcctatgcaa tgagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg ggtcgcagtc atctatgtta ttggtgccac tgactacgcg    180

agcagtgcga aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agtttatgat    300

tctgtctgga atcacttcaa cttgtggggc caagggaccc tcgtcaccgt ctcgagcgcc    360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa    660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg    720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac    840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc    900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa   1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc   1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg   1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1320

aagagcctct ccctgtctcc gggtaaa                                       1347


<210>  52
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  52
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt gcctatgcaa tgagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg ggtcgcagtc atctatgtta ttggtgccac tgactacgcg    180

agcagtgcga aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agtttatgat    300

tctgtctgga atcacttcaa cttgtggggc caagggaccc tcgtcaccgt ctcgagc       357


<210>  53
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  53
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt                                      90


<210>  54
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  54
gcctatgcaa tgagc                                                      15


<210>  55
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  55
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ca                        42


<210>  56
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  56
gtcatctatg ttattggtgc cactgactac gcgagcagtg cgaaaggc                  48


<210>  57
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  57
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg     60

agagctgagg acactgctgt gtattactgt gctaga                               96


<210>  58
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  58
gtttatgatt ctgtctggaa tcacttcaac ttg                                  33


<210>  59
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  59
tggggccaag ggaccctcgt caccgtctcg agc                                  33


<210>  60
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  60
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  61
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  62
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  63
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  64
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  64

Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  65
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  65

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  66
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  66

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  67
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  67

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  68
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  68

Gln Gln Ala Tyr Ser Val Ser Asn Val Asp Asn Ala 
1               5                   10          


<210>  69
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  69

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  70
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  70

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  71
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  71
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca    120

ggaaaagccc ctaagctcct gatctatcag gcatctaaac tggcatctgg agtcccatca    180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct    240

gatgattttg caacttatta ctgccaacag gcttatagtg ttagtaatgt tgataatgct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  72
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  72
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca    120

ggaaaagccc ctaagctcct gatctatcag gcatctaaac tggcatctgg agtcccatca    180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct    240

gatgattttg caacttatta ctgccaacag gcttatagtg ttagtaatgt tgataatgct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgt                                 333


<210>  73
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  73
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgc                                                             69


<210>  74
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  74
caggccagtc agagcattag cagttggtta gcc                                  33


<210>  75
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  75
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                     45


<210>  76
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  76
caggcatcta aactggcatc t                                               21


<210>  77
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  77
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc     60

agcctgcagc ctgatgattt tgcaacttat tactgc                               96


<210>  78
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  78
caacaggctt atagtgttag taatgttgat aatgct                               36


<210>  79
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  79
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                  33


<210>  80
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  80
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  81
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  81

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Thr Ile Ser Ser Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Thr Ile Asn Pro Gly Ala Asn Thr Tyr Phe Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Gly 
                85                  90                  95      


Asp Ser Asn Asp Trp Gly Val Phe Asp Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  82
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  82

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Thr Ile Ser Ser Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Thr Ile Asn Pro Gly Ala Asn Thr Tyr Phe Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Gly 
                85                  90                  95      


Asp Ser Asn Asp Trp Gly Val Phe Asp Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  83
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  83

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Thr Ile Ser 
            20                  25                  


<210>  84
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  84

Ser Tyr Tyr Met Ser 
1               5   


<210>  85
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  85

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  86
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  86

Thr Ile Asn Pro Gly Ala Asn Thr Tyr Phe Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  87
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  87

Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  88
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  88

Glu Gly Asp Ser Asn Asp Trp Gly Val Phe Asp Leu 
1               5                   10          


<210>  89
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  89

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  90
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  90

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  91
<211>  1341
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  91
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacaccctt gacactcacc     60

tgcacagtct ctggactcac cattagtagc tactacatga gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaaccatt aatcctggtg ctaacacata cttcgcgagc    180

tgggcaaaag gccgattcac catctccaga acctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacatat ttctgtgcca gagaggggga tagtaatgac    300

tggggtgtct ttgacttgtg gggccagggc accctggtca ccgtctcgag cgcctccacc    360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg    420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac    540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc    600

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt    660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc    720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca    780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac    840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac    900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag    960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa   1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag   1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag   1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc   1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg   1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc   1320

ctctccctgt ctccgggtaa a                                             1341


<210>  92
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  92
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacaccctt gacactcacc     60

tgcacagtct ctggactcac cattagtagc tactacatga gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaaccatt aatcctggtg ctaacacata cttcgcgagc    180

tgggcaaaag gccgattcac catctccaga acctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacatat ttctgtgcca gagaggggga tagtaatgac    300

tggggtgtct ttgacttgtg gggccagggc accctggtca ccgtctcgag c             351


<210>  93
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  93
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacaccctt gacactcacc     60

tgcacagtct ctggactcac cattagt                                         87


<210>  94
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  94
agctactaca tgagc                                                      15


<210>  95
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  95
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                        42


<210>  96
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  96
accattaatc ctggtgctaa cacatacttc gcgagctggg caaaaggc                  48


<210>  97
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  97
cgattcacca tctccagaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc     60

gaggacacgg ccacatattt ctgtgccaga                                      90


<210>  98
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  98
gagggggata gtaatgactg gggtgtcttt gacttg                               36


<210>  99
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  99
tggggccagg gcaccctggt caccgtctcg agc                                  33


<210>  100
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  100
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  101
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  101

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Ile Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Arg Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ile Asp Asn 
                85                  90                  95      


Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  102
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  102

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Ile Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Arg Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ile Asp Asn 
                85                  90                  95      


Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  103
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  103

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Ile Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Arg Cys 
            20              


<210>  104
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  104

Gln Ala Ser Glu Asp Ile Glu Ser Tyr Leu Ala 
1               5                   10      


<210>  105
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  105

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  106
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  106

Arg Ala Ser Asp Leu Ala Ser 
1               5           


<210>  107
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  107

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  108
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  108

Gln Gln Gly Tyr Thr Ile Asp Asn Val Asp Asn Thr 
1               5                   10          


<210>  109
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  109

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  110
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  110

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  111
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  111
gcctatgata tgacccagac tccagcctct gtagagatag ctgtgggagg cacagtcacc     60

atcaggtgcc aggccagtga ggacattgaa agctatttag cctggtatca gcagaaacca    120

gggcagcctc ccaaactcct gatctacagg gcatccgatc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacagac tacactctca ccatcagcgg cgtggagtgt    240

gacgatgctg ccacttacta ctgtcaacag ggttatacta tcgataatgt tgataatact    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  112
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  112
gcctatgata tgacccagac tccagcctct gtagagatag ctgtgggagg cacagtcacc     60

atcaggtgcc aggccagtga ggacattgaa agctatttag cctggtatca gcagaaacca    120

gggcagcctc ccaaactcct gatctacagg gcatccgatc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacagac tacactctca ccatcagcgg cgtggagtgt    240

gacgatgctg ccacttacta ctgtcaacag ggttatacta tcgataatgt tgataatact    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  113
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  113
gcctatgata tgacccagac tccagcctct gtagagatag ctgtgggagg cacagtcacc     60

atcaggtgc                                                             69


<210>  114
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  114
caggccagtg aggacattga aagctattta gcc                                  33


<210>  115
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  115
tggtatcagc agaaaccagg gcagcctccc aaactcctga tctac                     45


<210>  116
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  116
agggcatccg atctggcatc t                                               21


<210>  117
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  117
ggggtctcat cgcggttcaa aggcagtgga tctgggacag actacactct caccatcagc     60

ggcgtggagt gtgacgatgc tgccacttac tactgt                               96


<210>  118
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  118
caacagggtt atactatcga taatgttgat aatact                               36


<210>  119
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  119
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  120
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  120
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  121
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  121

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Ser Cys Thr Ala Ser Gly Leu Thr Ile Ser Ser Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
        35                  40                  45              


Thr Ile Asn Pro Gly Ala Asn Thr Tyr Phe Ala Ser Ser Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Ser Ser Thr Thr Leu Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Pro Thr Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Glu Gly 
                85                  90                  95      


Asp Ser Asn Asp Trp Gly Val Phe Asp Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  122
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  122

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Ser Cys Thr Ala Ser Gly Leu Thr Ile Ser Ser Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
        35                  40                  45              


Thr Ile Asn Pro Gly Ala Asn Thr Tyr Phe Ala Ser Ser Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Ser Ser Thr Thr Leu Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Pro Thr Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Glu Gly 
                85                  90                  95      


Asp Ser Asn Asp Trp Gly Val Phe Asp Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  123
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  123

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Ser Cys Thr Ala Ser Gly Leu Thr Ile Ser 
            20                  25                  


<210>  124
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  124

Ser Tyr Tyr Met Ser 
1               5   


<210>  125
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  125

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  126
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  126

Thr Ile Asn Pro Gly Ala Asn Thr Tyr Phe Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  127
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  127

Arg Phe Thr Ile Ser Arg Ser Ser Thr Thr Leu Asp Leu Lys Met Thr 
1               5                   10                  15      


Ser Pro Thr Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30  


<210>  128
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  128

Glu Gly Asp Ser Asn Asp Trp Gly Val Phe Asp Leu 
1               5                   10          


<210>  129
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  129

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  130
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  130

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  131
<211>  1341
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  131
cagtcgctgg aggagtctgg gggacgcttg gtccagcctg ggacacccct gacactctcc     60

tgtacagcct ctggactcac cattagtagc tactacatga gctgggtccg tcaggctcca    120

gggaaggggc tggagtgggt cggaaccatc aatcctggtg ctaacacata cttcgcgagc    180

tctgcaaaag gccgattcac catctccaga tcctcgacca ccctggatct taagatgacc    240

agcccgacag ctgaggacac tgctacatat tactgtgcta gagaggggga tagtaatgac    300

tggggtgtct ttgacttgtg gggccaaggg accctcgtca ccgtctcgag cgcctccacc    360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg    420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac    540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc    600

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt    660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc    720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca    780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac    840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac    900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag    960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa   1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag   1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag   1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc   1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg   1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc   1320

ctctccctgt ctccgggtaa a                                             1341


<210>  132
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  132
cagtcgctgg aggagtctgg gggacgcttg gtccagcctg ggacacccct gacactctcc     60

tgtacagcct ctggactcac cattagtagc tactacatga gctgggtccg tcaggctcca    120

gggaaggggc tggagtgggt cggaaccatc aatcctggtg ctaacacata cttcgcgagc    180

tctgcaaaag gccgattcac catctccaga tcctcgacca ccctggatct taagatgacc    240

agcccgacag ctgaggacac tgctacatat tactgtgcta gagaggggga tagtaatgac    300

tggggtgtct ttgacttgtg gggccaaggg accctcgtca ccgtctcgag c             351


<210>  133
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  133
cagtcgctgg aggagtctgg gggacgcttg gtccagcctg ggacacccct gacactctcc     60

tgtacagcct ctggactcac cattagt                                         87


<210>  134
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  134
agctactaca tgagc                                                      15


<210>  135
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  135
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                        42


<210>  136
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  136
accatcaatc ctggtgctaa cacatacttc gcgagctctg caaaaggc                  48


<210>  137
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  137
cgattcacca tctccagatc ctcgaccacc ctggatctta agatgaccag cccgacagct     60

gaggacactg ctacatatta ctgtgctaga                                      90


<210>  138
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  138
gagggggata gtaatgactg gggtgtcttt gacttg                               36


<210>  139
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  139
tggggccaag ggaccctcgt caccgtctcg agc                                  33


<210>  140
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  140
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  141
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  141

Ala Tyr Asp Met Thr Gln Ser Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Arg Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Gly Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ile Asp Asn 
                85                  90                  95      


Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  142
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  142

Ala Tyr Asp Met Thr Gln Ser Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Arg Cys Gln Ala Ser Glu Asp Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Gly Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Thr Ile Asp Asn 
                85                  90                  95      


Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  143
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  143

Ala Tyr Asp Met Thr Gln Ser Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Arg Cys 
            20              


<210>  144
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  144

Gln Ala Ser Glu Asp Ile Glu Ser Tyr Leu Ala 
1               5                   10      


<210>  145
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  145

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  146
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  146

Arg Ala Ser Asp Leu Ala Ser 
1               5           


<210>  147
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  147

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Glu Pro Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  148
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  148

Gln Gln Gly Tyr Thr Ile Asp Asn Val Asp Asn Thr 
1               5                   10          


<210>  149
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  149

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  150
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  150

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  151
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  151
gcctatgata tgacccagtc tccagcctcc gtggaggcag ccgtaggagg cacagtcacc     60

atcaggtgtc aggccagtga ggacattgaa agctacttag cctggtatca gcagaaacca    120

gggcagcctc ctaagctcct gatctatagg gcatccgatc tggcatctgg ggtctcatca    180

aggttcaaag gcagtggatc tgggacagat tacactctca ccatcagcgg cctggagcct    240

gaagatgctg caacttacta ttgtcaacag ggttatacta tcgataatgt tgacaatact    300

ttcggcggag gaaccaaggt ggaaatcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  152
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  152
gcctatgata tgacccagtc tccagcctcc gtggaggcag ccgtaggagg cacagtcacc     60

atcaggtgtc aggccagtga ggacattgaa agctacttag cctggtatca gcagaaacca    120

gggcagcctc ctaagctcct gatctatagg gcatccgatc tggcatctgg ggtctcatca    180

aggttcaaag gcagtggatc tgggacagat tacactctca ccatcagcgg cctggagcct    240

gaagatgctg caacttacta ttgtcaacag ggttatacta tcgataatgt tgacaatact    300

ttcggcggag gaaccaaggt ggaaatcaaa cgt                                 333


<210>  153
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  153
gcctatgata tgacccagtc tccagcctcc gtggaggcag ccgtaggagg cacagtcacc     60

atcaggtgt                                                             69


<210>  154
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  154
caggccagtg aggacattga aagctactta gcc                                  33


<210>  155
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  155
tggtatcagc agaaaccagg gcagcctcct aagctcctga tctat                     45


<210>  156
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  156
agggcatccg atctggcatc t                                               21


<210>  157
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  157
ggggtctcat caaggttcaa aggcagtgga tctgggacag attacactct caccatcagc     60

ggcctggagc ctgaagatgc tgcaacttac tattgt                               96


<210>  158
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  158
caacagggtt atactatcga taatgttgac aatact                               36


<210>  159
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  159
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                  33


<210>  160
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  160
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  161
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  161

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Ala 
            20                  25                  30          


Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Leu Ser Gly Asn Thr Asp Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Lys Phe 
                85                  90                  95      


Asp Thr Gly Tyr Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  162
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  162

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Ala 
            20                  25                  30          


Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Leu Ser Gly Asn Thr Asp Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Lys Phe 
                85                  90                  95      


Asp Thr Gly Tyr Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  163
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  163

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn 
            20                  25                  


<210>  164
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  164

Asn Tyr Ala Val Gly 
1               5   


<210>  165
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  165

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  166
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  166

Ile Ile Tyr Leu Ser Gly Asn Thr Asp Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  167
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  167

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  168
<211>  8
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  168

Lys Phe Asp Thr Gly Tyr Asp Ile 
1               5               


<210>  169
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  169

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  170
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  170

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  171
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  171
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcaataat tatgcagtgg gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaatcatt taccttagtg gtaacacaga ctacgcgaac    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca ggaaatttga tacgggatat    300

gacatctggg gcccaggcac cctcgtcacc gtctcgagcg cctccaccaa gggcccatcg    360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc    420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc    480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc    540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac    600

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac    660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc    720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg    840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc    900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc    960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga   1020

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc   1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat   1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1320

ccgggtaaa                                                           1329


<210>  172
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  172
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcaataat tatgcagtgg gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaatcatt taccttagtg gtaacacaga ctacgcgaac    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca ggaaatttga tacgggatat    300

gacatctggg gcccaggcac cctcgtcacc gtctcgagc                           339


<210>  173
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  173
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcaat                                         87


<210>  174
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  174
aattatgcag tgggc                                                      15


<210>  175
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  175
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                        42


<210>  176
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  176
atcatttacc ttagtggtaa cacagactac gcgaactggg cgaaaggc                  48


<210>  177
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  177
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccagg                                      90


<210>  178
<211>  24
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  178
aaatttgata cgggatatga catc                                            24


<210>  179
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  179
tggggcccag gcaccctcgt caccgtctcg agc                                  33


<210>  180
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  180
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  181
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  181

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Met Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asp Trp Ser Asp Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  182
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  182

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Met Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asp Trp Ser Asp Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  183
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  183

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Met Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  184
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  184

Gln Ala Ser Gln Ser Ile Ser Thr Tyr Leu Ala 
1               5                   10      


<210>  185
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  185

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  186
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  186

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  187
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  187

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  188
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  188

Gln Gln Asp Trp Ser Asp Ser Asn Val Asp Asn Ala 
1               5                   10          


<210>  189
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  189

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  190
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  190

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  191
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  191
gcctatgata tgacccagac tccagcctct atggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtca gagcattagt acctacttag cctggtatca gcagaaacca    120

gggcagcctc ccaagctcct gatctatgat gcatccgatc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt    240

gacgatgctg ccacttacta ctgtcaacag gattggagtg atagtaatgt tgataatgct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  192
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  192
gcctatgata tgacccagac tccagcctct atggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtca gagcattagt acctacttag cctggtatca gcagaaacca    120

gggcagcctc ccaagctcct gatctatgat gcatccgatc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt    240

gacgatgctg ccacttacta ctgtcaacag gattggagtg atagtaatgt tgataatgct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  193
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  193
gcctatgata tgacccagac tccagcctct atggaggtag ctgtgggagg cacagtcacc     60

atcaagtgc                                                             69


<210>  194
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  194
caggccagtc agagcattag tacctactta gcc                                  33


<210>  195
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  195
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctat                     45


<210>  196
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  196
gatgcatccg atctggcatc t                                               21


<210>  197
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  197
ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc     60

ggcgtggagt gtgacgatgc tgccacttac tactgt                               96


<210>  198
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  198
caacaggatt ggagtgatag taatgttgat aatgct                               36


<210>  199
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  199
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  200
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  200
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  201
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  201

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Met Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Trp Ala Gln Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Pro 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val Tyr 
                85                  90                  95      


Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  202
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  202

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Met Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Trp Ala Gln Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Pro 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val Tyr 
                85                  90                  95      


Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  203
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  203

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Met Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  204
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  204

Ser Asn Ala Ile Ser 
1               5   


<210>  205
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  205

Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  206
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  206

Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Trp Ala Gln Gly 
1               5                   10                  15      


<210>  207
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  207

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Pro 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  208
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  208

Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu 
1               5                   10      


<210>  209
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  209

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  210
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  210

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  211
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  211
cagtcggtgg aggagtccgg gggtcgcctg gtcatgcctg ggacacccct gacactcacc     60

tgcaccgtct ctggattctc cctcagtagc aatgcaataa gctgggtccg ccaggctcca    120

gagaaggggc tggaatggat cggagtcatt tatgttattg gtgtcactga ctacgcgagc    180

tgggcgcaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcccc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagtttatga ttctggctgg    300

aatcacttta acttgtgggg cccgggcacc ctcgtcaccg tctcgagcgc ctccaccaag    360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc    420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc    480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc    540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac    600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac    660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc    720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc    780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc    840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt    900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc    960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg   1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac   1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg   1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac   1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac   1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc   1320

tccctgtctc cgggtaaa                                                 1338


<210>  212
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  212
cagtcggtgg aggagtccgg gggtcgcctg gtcatgcctg ggacacccct gacactcacc     60

tgcaccgtct ctggattctc cctcagtagc aatgcaataa gctgggtccg ccaggctcca    120

gagaaggggc tggaatggat cggagtcatt tatgttattg gtgtcactga ctacgcgagc    180

tgggcgcaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcccc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagtttatga ttctggctgg    300

aatcacttta acttgtgggg cccgggcacc ctcgtcaccg tctcgagc                 348


<210>  213
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  213
cagtcggtgg aggagtccgg gggtcgcctg gtcatgcctg ggacacccct gacactcacc     60

tgcaccgtct ctggattctc cctcagt                                         87


<210>  214
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  214
agcaatgcaa taagc                                                      15


<210>  215
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  215
tgggtccgcc aggctccaga gaaggggctg gaatggatcg ga                        42


<210>  216
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  216
gtcatttatg ttattggtgt cactgactac gcgagctggg cgcaaggc                  48


<210>  217
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  217
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatccccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  218
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  218
gtttatgatt ctggctggaa tcactttaac ttg                                  33


<210>  219
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  219
tggggcccgg gcaccctcgt caccgtctcg agc                                  33


<210>  220
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  220
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  221
<211>  222
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  221

Ala Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asn Ile Tyr Arg 
            20                  25                  30          


Leu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Arg Ser Ser Tyr Asp Thr Tyr Asn Val Phe Gly Gly Gly Thr Glu Val 
            100                 105                 110         


Val Val Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    130                 135                 140                 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
145                 150                 155                 160 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
                165                 170                 175     


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
            180                 185                 190         


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        195                 200                 205             


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220         


<210>  222
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  222

Ala Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asn Ile Tyr Arg 
            20                  25                  30          


Leu Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser Ser 
                85                  90                  95      


Arg Ser Ser Tyr Asp Thr Tyr Asn Val Phe Gly Gly Gly Thr Glu Val 
            100                 105                 110         


Val Val Lys Arg 
        115     


<210>  223
<211>  24
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  223

Ala Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys 
            20                  


<210>  224
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  224

Gln Ala Ser Glu Asn Ile Tyr Arg Leu Leu Ala 
1               5                   10      


<210>  225
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  225

Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  226
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  226

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  227
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  227

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  228
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  228

Gln Asn Tyr Tyr Tyr Ser Ser Arg Ser Ser Tyr Asp Thr Tyr Asn Val 
1               5                   10                  15      


<210>  229
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  229

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  230
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  230

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  231
<211>  666
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  231
gctgacattg tgatgaccca gactccatcc tccgtggagg cagctgtggg aggcacagtc     60

accatcaagt gccaggccag tgagaacatt tataggttat tggcctggta tcagcagaaa    120

ccagggcagc gtcccaagct cctgatctat tctgcatcca ctctggcatc tggggtccca    180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag    240

tgtgccgatg ctgccactta ctactgtcaa aactattatt atagtagtag gagtagttat    300

gatacatata atgttttcgg cggagggacc gaggtggtgg tcaaacgtac ggtagcggcc    360

ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt    420

gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac    480

gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc    540

tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac    600

gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga    660

gagtgt                                                               666


<210>  232
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  232
gctgacattg tgatgaccca gactccatcc tccgtggagg cagctgtggg aggcacagtc     60

accatcaagt gccaggccag tgagaacatt tataggttat tggcctggta tcagcagaaa    120

ccagggcagc gtcccaagct cctgatctat tctgcatcca ctctggcatc tggggtccca    180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag    240

tgtgccgatg ctgccactta ctactgtcaa aactattatt atagtagtag gagtagttat    300

gatacatata atgttttcgg cggagggacc gaggtggtgg tcaaacgt                 348


<210>  233
<211>  72
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  233
gctgacattg tgatgaccca gactccatcc tccgtggagg cagctgtggg aggcacagtc     60

accatcaagt gc                                                         72


<210>  234
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  234
caggccagtg agaacattta taggttattg gcc                                  33


<210>  235
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  235
tggtatcagc agaaaccagg gcagcgtccc aagctcctga tctat                     45


<210>  236
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  236
tctgcatcca ctctggcatc t                                               21


<210>  237
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  237
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc     60

gacctggagt gtgccgatgc tgccacttac tactgt                               96


<210>  238
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  238
caaaactatt attatagtag taggagtagt tatgatacat ataatgtt                  48


<210>  239
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  239
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  240
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  240
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  241
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  241

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Met Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Trp Ala Gln Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Pro 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val Tyr 
                85                  90                  95      


Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  242
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  242

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Met Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Asn Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Trp Ala Gln Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Pro 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val Tyr 
                85                  90                  95      


Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  243
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  243

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Met Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  244
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  244

Ser Asn Ala Ile Ser 
1               5   


<210>  245
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  245

Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  246
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  246

Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Trp Ala Gln Gly 
1               5                   10                  15      


<210>  247
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  247

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Pro 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  248
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  248

Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu 
1               5                   10      


<210>  249
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  249

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  250
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  250

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  251
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  251
cagtcggtgg aggagtccgg gggtcgcctg gtcatgcctg ggacacccct gacactcacc     60

tgcaccgtct ctggattctc cctcagtagc aatgcaataa gctgggtccg ccaggctcca    120

gagaaggggc tggaatggat cggagtcatt tatgttattg gtgtcactga ctacgcgagc    180

tgggcgcaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcccc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagtttatga ttctggctgg    300

aatcacttta acttgtgggg cccagggacc ctcgtcaccg tctcgagcgc ctccaccaag    360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc    420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc    480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc    540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac    600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac    660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc    720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc    780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc    840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt    900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc    960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg   1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac   1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg   1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac   1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac   1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc   1320

tccctgtctc cgggtaaa                                                 1338


<210>  252
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  252
cagtcggtgg aggagtccgg gggtcgcctg gtcatgcctg ggacacccct gacactcacc     60

tgcaccgtct ctggattctc cctcagtagc aatgcaataa gctgggtccg ccaggctcca    120

gagaaggggc tggaatggat cggagtcatt tatgttattg gtgtcactga ctacgcgagc    180

tgggcgcaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcccc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagtttatga ttctggctgg    300

aatcacttta acttgtgggg cccagggacc ctcgtcaccg tctcgagc                 348


<210>  253
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  253
cagtcggtgg aggagtccgg gggtcgcctg gtcatgcctg ggacacccct gacactcacc     60

tgcaccgtct ctggattctc cctcagt                                         87


<210>  254
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  254
agcaatgcaa taagc                                                      15


<210>  255
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  255
tgggtccgcc aggctccaga gaaggggctg gaatggatcg ga                        42


<210>  256
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  256
gtcatttatg ttattggtgt cactgactac gcgagctggg cgcaaggc                  48


<210>  257
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  257
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatccccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  258
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  258
gtttatgatt ctggctggaa tcactttaac ttg                                  33


<210>  259
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  259
tggggcccag ggaccctcgt caccgtctcg agc                                  33


<210>  260
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  260
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  261
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  261

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ala Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  262
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  262

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ala Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  263
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  263

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  264
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  264

Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  265
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  265

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  266
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  266

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  267
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  267

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  268
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  268

Gln Gln Ala Tyr Ser Val Ala Asn Val Asp Asn Ala 
1               5                   10          


<210>  269
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  269

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  270
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  270

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  271
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  271
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca    120

gggcagcctc caaagctcct gatctacgaa gcatccaaac tggcatctgg ggtcccatcg    180

cggttcagtg gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ctgtcaacag gcttatagtg ttgccaatgt tgataatgct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  272
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  272
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca    120

gggcagcctc caaagctcct gatctacgaa gcatccaaac tggcatctgg ggtcccatcg    180

cggttcagtg gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ctgtcaacag gcttatagtg ttgccaatgt tgataatgct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  273
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  273
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgc                                                             69


<210>  274
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  274
caggccagtc agagcattag cagttggtta gcc                                  33


<210>  275
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  275
tggtatcagc agaaaccagg gcagcctcca aagctcctga tctac                     45


<210>  276
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  276
gaagcatcca aactggcatc t                                               21


<210>  277
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  277
ggggtcccat cgcggttcag tggcagtgga tctgggacac agttcactct caccatcagc     60

ggcgtggagt gtgccgatgc tgccacttac tactgt                               96


<210>  278
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  278
caacaggctt atagtgttgc caatgttgat aatgct                               36


<210>  279
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  279
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  280
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  280
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  281
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  281

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Ser Ala Gln 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  282
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  282

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Ser Ala Gln 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  283
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  283

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  284
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  284

Ser Asn Ala Ile Ser 
1               5   


<210>  285
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  285

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  286
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  286

Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Ser Ala Gln Gly 
1               5                   10                  15      


<210>  287
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  287

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  288
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  288

Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu 
1               5                   10      


<210>  289
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  289

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  290
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  290

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  291
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  291
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt agcaatgcaa taagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg ggtcggagtc atttatgtta ttggtgtcac tgactacgcg    180

agctctgcgc aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agtttatgat    300

tctggctgga atcactttaa cttgtggggc caagggaccc tcgtcaccgt ctcgagcgcc    360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa    660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg    720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac    840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc    900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa   1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc   1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg   1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1320

aagagcctct ccctgtctcc gggtaaa                                       1347


<210>  292
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  292
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt agcaatgcaa taagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg ggtcggagtc atttatgtta ttggtgtcac tgactacgcg    180

agctctgcgc aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agtttatgat    300

tctggctgga atcactttaa cttgtggggc caagggaccc tcgtcaccgt ctcgagc       357


<210>  293
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  293
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt                                      90


<210>  294
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  294
agcaatgcaa taagc                                                      15


<210>  295
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  295
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                        42


<210>  296
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  296
gtcatttatg ttattggtgt cactgactac gcgagctctg cgcaaggc                  48


<210>  297
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  297
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg     60

agagctgagg acactgctgt gtattactgt gctaga                               96


<210>  298
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  298
gtttatgatt ctggctggaa tcactttaac ttg                                  33


<210>  299
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  299
tggggccaag ggaccctcgt caccgtctcg agc                                  33


<210>  300
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  300
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  301
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  301

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ala Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  302
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  302

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ala Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  303
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  303

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  304
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  304

Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  305
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  305

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  306
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  306

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  307
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  307

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  308
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  308

Gln Gln Ala Tyr Ser Val Ala Asn Val Asp Asn Ala 
1               5                   10          


<210>  309
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  309

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  310
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  310

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  311
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  311
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca    120

ggaaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg agtcccatca    180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct    240

gatgattttg caacttatta ctgccaacag gcttatagtg ttgccaatgt tgataatgct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  312
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  312
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca    120

ggaaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg agtcccatca    180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct    240

gatgattttg caacttatta ctgccaacag gcttatagtg ttgccaatgt tgataatgct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgt                                 333


<210>  313
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  313
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgc                                                             69


<210>  314
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  314
caggccagtc agagcattag cagttggtta gcc                                  33


<210>  315
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  315
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                     45


<210>  316
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  316
gaagcatcca aactggcatc t                                               21


<210>  317
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  317
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc     60

agcctgcagc ctgatgattt tgcaacttat tactgc                               96


<210>  318
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  318
caacaggctt atagtgttgc caatgttgat aatgct                               36


<210>  319
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  319
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                  33


<210>  320
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  320
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  321
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  321

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Ser Asn Gly 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ser Ser Ile Asp Gly Thr Thr Tyr Tyr Thr Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Gly 
                85                  90                  95      


Glu Tyr Ala Gly Val Val Gly Ser Asn Tyr Phe Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  322
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  322

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn Ser Asn Gly 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ser Ser Ile Asp Gly Thr Thr Tyr Tyr Thr Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg Gly 
                85                  90                  95      


Glu Tyr Ala Gly Val Val Gly Ser Asn Tyr Phe Asp Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  323
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  323

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Asn 
            20                  25                  


<210>  324
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  324

Ser Asn Gly Met Ser 
1               5   


<210>  325
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  325

Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  326
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  326

Ala Ser Ser Ile Asp Gly Thr Thr Tyr Tyr Thr Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  327
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  327

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Ile 
1               5                   10                  15      


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Thr Arg 
            20                  25                  30      


<210>  328
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  328

Gly Glu Tyr Ala Gly Val Val Gly Ser Asn Tyr Phe Asp Leu 
1               5                   10                  


<210>  329
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  329

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  330
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  330

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  331
<211>  1350
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  331
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtgt ctggaatcga cctcaatagc aatggaatga gctgggtccg ccaggctcca    120

ggggaggggc tggaatggat cggagccagt agtattgatg ggaccacata ctacaccaat    180

tgggcgaagg gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatc    240

accagtccga caaccgagga cacggccacc tatttctgta ccagagggga gtatgctggt    300

gttgttggtt cgaactactt tgacttgtgg ggccagggca ccctcgtcac cgtctcgagc    360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg    420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc   1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag   1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc   1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg   1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg   1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg   1320

cagaagagcc tctccctgtc tccgggtaaa                                    1350


<210>  332
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  332
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtgt ctggaatcga cctcaatagc aatggaatga gctgggtccg ccaggctcca    120

ggggaggggc tggaatggat cggagccagt agtattgatg ggaccacata ctacaccaat    180

tgggcgaagg gccgattcac catctccaaa acctcgtcga ccacggtgga tctgaaaatc    240

accagtccga caaccgagga cacggccacc tatttctgta ccagagggga gtatgctggt    300

gttgttggtt cgaactactt tgacttgtgg ggccagggca ccctcgtcac cgtctcgagc    360


<210>  333
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  333
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtgt ctggaatcga cctcaat                                         87


<210>  334
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  334
agcaatggaa tgagc                                                      15


<210>  335
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  335
tgggtccgcc aggctccagg ggaggggctg gaatggatcg ga                        42


<210>  336
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  336
gccagtagta ttgatgggac cacatactac accaattggg cgaagggc                  48


<210>  337
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  337
cgattcacca tctccaaaac ctcgtcgacc acggtggatc tgaaaatcac cagtccgaca     60

accgaggaca cggccaccta tttctgtacc aga                                  93


<210>  338
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  338
ggggagtatg ctggtgttgt tggttcgaac tactttgact tg                        42


<210>  339
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  339
tggggccagg gcaccctcgt caccgtctcg agc                                  33


<210>  340
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  340
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  341
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  341

Gln Val Leu Thr Gln Thr Pro Pro Ser Val Ser Ala Val Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Arg Ile Tyr Ser Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Ser Tyr Tyr Cys Ala Gly Tyr Tyr Ser Gly His Ile 
                85                  90                  95      


Tyr Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  342
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  342

Gln Val Leu Thr Gln Thr Pro Pro Ser Val Ser Ala Val Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Arg Ile Tyr Ser Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Ser Tyr Tyr Cys Ala Gly Tyr Tyr Ser Gly His Ile 
                85                  90                  95      


Tyr Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 


<210>  343
<211>  22
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  343

Gln Val Leu Thr Gln Thr Pro Pro Ser Val Ser Ala Val Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys 
            20          


<210>  344
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  344

Gln Ser Ser Gln Arg Ile Tyr Ser Asn Trp Leu Ser 
1               5                   10          


<210>  345
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  345

Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Lys Pro Leu Ile Tyr 
1               5                   10                  15  


<210>  346
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  346

Ala Ala Ser Ser Leu Ala Ser 
1               5           


<210>  347
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  347

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Ser Tyr Tyr Cys 
            20                  25                  30          


<210>  348
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  348

Ala Gly Tyr Tyr Ser Gly His Ile Tyr Ser 
1               5                   10  


<210>  349
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  349

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  350
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  350

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  351
<211>  645
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  351
caagtgctga cccagactcc accctccgtg tctgcagttg tgggaggcac agtcaccatc     60

aattgccagt ccagtcagag gatttatagt aattggttat cttggtatca gcagaaacca    120

gggcagactc ccaagcccct gatctatgct gcatccagcc tggcatctgg ggtcccatcg    180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcga cctggagtgt    240

gacgatgctg ccagttacta ctgtgcaggc tattatagtg gtcatattta ttctttcggc    300

ggagggaccg aggtggtggt caaacgtacg gtagcggccc catctgtctt catcttcccg    360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc    420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc    480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg    540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag    600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                    645


<210>  352
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  352
caagtgctga cccagactcc accctccgtg tctgcagttg tgggaggcac agtcaccatc     60

aattgccagt ccagtcagag gatttatagt aattggttat cttggtatca gcagaaacca    120

gggcagactc ccaagcccct gatctatgct gcatccagcc tggcatctgg ggtcccatcg    180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcga cctggagtgt    240

gacgatgctg ccagttacta ctgtgcaggc tattatagtg gtcatattta ttctttcggc    300

ggagggaccg aggtggtggt caaacgt                                        327


<210>  353
<211>  66
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  353
caagtgctga cccagactcc accctccgtg tctgcagttg tgggaggcac agtcaccatc     60

aattgc                                                                66


<210>  354
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  354
cagtccagtc agaggattta tagtaattgg ttatct                               36


<210>  355
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  355
tggtatcagc agaaaccagg gcagactccc aagcccctga tctat                     45


<210>  356
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  356
gctgcatcca gcctggcatc t                                               21


<210>  357
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  357
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc     60

gacctggagt gtgacgatgc tgccagttac tactgt                               96


<210>  358
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  358
gcaggctatt atagtggtca tatttattct                                      30


<210>  359
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  359
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  360
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  360
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  361
<211>  452
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  361

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ser Ser Ile Asp Gly Thr Thr Tyr Tyr Thr Asn Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Glu Tyr Ala Gly Val Val Gly Ser Asn Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  362
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  362

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ser Ser Ile Asp Gly Thr Thr Tyr Tyr Thr Asn Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Glu Tyr Ala Gly Val Val Gly Ser Asn Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  363
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  363

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  364
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  364

Ser Asn Gly Met Ser 
1               5   


<210>  365
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  365

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  366
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  366

Ala Ser Ser Ile Asp Gly Thr Thr Tyr Tyr Thr Asn Ser Ala Lys Gly 
1               5                   10                  15      


<210>  367
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  367

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  368
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  368

Gly Glu Tyr Ala Gly Val Val Gly Ser Asn Tyr Phe Asp Leu 
1               5                   10                  


<210>  369
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  369

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  370
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  370

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  371
<211>  1356
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  371
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt agcaatggaa tgagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg ggtcggagcc agtagtattg atgggaccac atactacacc    180

aattctgcga agggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag aggggagtat    300

gctggtgttg ttggttcgaa ctactttgac ttgtggggcc aagggaccct cgtcaccgtc    360

tcgagcgcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc    420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg    480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag    540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc    600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt    660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg    720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg    780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc    840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag    900

tacgccagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat    960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc   1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg   1080

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc   1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct   1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc   1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac   1320

tacacgcaga agagcctctc cctgtctccg ggtaaa                             1356


<210>  372
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  372
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt agcaatggaa tgagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg ggtcggagcc agtagtattg atgggaccac atactacacc    180

aattctgcga agggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag aggggagtat    300

gctggtgttg ttggttcgaa ctactttgac ttgtggggcc aagggaccct cgtcaccgtc    360

tcgagc                                                               366


<210>  373
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  373
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt                                      90


<210>  374
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  374
agcaatggaa tgagc                                                      15


<210>  375
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  375
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                        42


<210>  376
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  376
gccagtagta ttgatgggac cacatactac accaattctg cgaagggc                  48


<210>  377
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  377
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg     60

agagctgagg acactgctgt gtattactgt gctaga                               96


<210>  378
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  378
ggggagtatg ctggtgttgt tggttcgaac tactttgact tg                        42


<210>  379
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  379
tggggccaag ggaccctcgt caccgtctcg agc                                  33


<210>  380
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  380
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  381
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  381

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Arg Ile Tyr Ser Asn 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Tyr Tyr Ser Gly His 
                85                  90                  95      


Ile Tyr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  382
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  382

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Arg Ile Tyr Ser Asn 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Tyr Tyr Ser Gly His 
                85                  90                  95      


Ile Tyr Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110 


<210>  383
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  383

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  384
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  384

Gln Ser Ser Gln Arg Ile Tyr Ser Asn Trp Leu Ser 
1               5                   10          


<210>  385
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  385

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  386
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  386

Ala Ala Ser Ser Leu Ala Ser 
1               5           


<210>  387
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  387

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  388
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  388

Ala Gly Tyr Tyr Ser Gly His Ile Tyr Ser 
1               5                   10  


<210>  389
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  389

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  390
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  390

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  391
<211>  648
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  391
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc     60

atcacttgtc agtccagtca gaggatctat agtaattggt tatcttggta tcagcagaaa    120

ccagggaaag cccctaagct cctgatctat gctgcatcca gcctggcatc tggggtccca    180

tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag    240

cctgaagatt ttgcaactta ctattgtgca ggctactata gtggtcatat ctattctttc    300

ggcggaggaa ccaaggtgga aatcaaacgt acggtagcgg ccccatctgt cttcatcttc    360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 648


<210>  392
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  392
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc     60

atcacttgtc agtccagtca gaggatctat agtaattggt tatcttggta tcagcagaaa    120

ccagggaaag cccctaagct cctgatctat gctgcatcca gcctggcatc tggggtccca    180

tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag    240

cctgaagatt ttgcaactta ctattgtgca ggctactata gtggtcatat ctattctttc    300

ggcggaggaa ccaaggtgga aatcaaacgt                                     330


<210>  393
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  393
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc     60

atcacttgt                                                             69


<210>  394
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  394
cagtccagtc agaggatcta tagtaattgg ttatct                               36


<210>  395
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  395
tggtatcagc agaaaccagg gaaagcccct aagctcctga tctat                     45


<210>  396
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  396
gctgcatcca gcctggcatc t                                               21


<210>  397
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  397
ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc     60

agcctgcagc ctgaagattt tgcaacttac tattgt                               96


<210>  398
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  398
gcaggctact atagtggtca tatctattct                                      30


<210>  399
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  399
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                  33


<210>  400
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  400
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  401
<211>  458
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  401

Gln Ser Met Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asp Tyr Ala 
            20                  25                  30          


Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Met Ile Ser Ser Gly Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Lys 
                85                  90                  95      


Asp Ala Ser Ser Gly Gly Tyr Leu Val Leu Asp Leu Leu Asp Val Pro 
            100                 105                 110         


Asp Gly Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  402
<211>  128
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  402

Gln Ser Met Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asp Tyr Ala 
            20                  25                  30          


Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Met Ile Ser Ser Gly Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Lys 
                85                  90                  95      


Asp Ala Ser Ser Gly Gly Tyr Leu Val Leu Asp Leu Leu Asp Val Pro 
            100                 105                 110         


Asp Gly Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  403
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  403

Gln Ser Met Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  404
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  404

Asp Tyr Ala Leu Ser 
1               5   


<210>  405
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  405

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  406
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  406

Met Ile Ser Ser Gly Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  407
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  407

Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  408
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  408

Asp Lys Asp Ala Ser Ser Gly Gly Tyr Leu Val Leu Asp Leu Leu Asp 
1               5                   10                  15      


Val Pro Asp Gly Met Asp Leu 
            20              


<210>  409
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  409

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  410
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  410

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  411
<211>  1374
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  411
cagtcaatgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagtgac tatgcgttga gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaatgatt agtagtggtg acaacacata ctacgcgagc    180

tgggcgaaag gccgattcac catctccaaa gcctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagataaaga tgctagtagt    300

ggtggttatt tggtccttga cctattggat gtccccgacg gcatggacct ctggggccca    360

ggcaccctcg tcaccgtctc gagcgcctcc accaagggcc catcggtctt ccccctggca    420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac    480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc    540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc    600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc    660

aaggtggaca agagagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc    720

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac    780

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa    840

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca    900

aagccgcggg aggagcagta cgccagcacg taccgtgtgg tcagcgtcct caccgtcctg    960

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca   1020

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac   1080

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc   1140

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac   1200

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag   1260

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat   1320

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa         1374


<210>  412
<211>  384
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  412
cagtcaatgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagtgac tatgcgttga gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaatgatt agtagtggtg acaacacata ctacgcgagc    180

tgggcgaaag gccgattcac catctccaaa gcctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagataaaga tgctagtagt    300

ggtggttatt tggtccttga cctattggat gtccccgacg gcatggacct ctggggccca    360

ggcaccctcg tcaccgtctc gagc                                           384


<210>  413
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  413
cagtcaatgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagt                                         87


<210>  414
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  414
gactatgcgt tgagc                                                      15


<210>  415
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  415
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                        42


<210>  416
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  416
atgattagta gtggtgacaa cacatactac gcgagctggg cgaaaggc                  48


<210>  417
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  417
cgattcacca tctccaaagc ctcgaccacg gtggatctga aaatcaccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  418
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  418
gataaagatg ctagtagtgg tggttatttg gtccttgacc tattggatgt ccccgacggc     60

atggacctc                                                             69


<210>  419
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  419
tggggcccag gcaccctcgt caccgtctcg agc                                  33


<210>  420
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  420
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  421
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  421

Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn Asn 
            20                  25                  30          


Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Trp Gly Ala Ser Tyr Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Gly Asp 
                85                  90                  95      


Ala Asp Thr Tyr Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  422
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  422

Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Lys Cys Gln Ser Ser Gln Ser Val Tyr Asn Asn Asn 
            20                  25                  30          


Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Trp Gly Ala Ser Tyr Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Gly Asp 
                85                  90                  95      


Ala Asp Thr Tyr Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  423
<211>  22
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  423

Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Lys Cys 
            20          


<210>  424
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  424

Gln Ser Ser Gln Ser Val Tyr Asn Asn Asn Leu Leu Ser 
1               5                   10              


<210>  425
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  425

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Trp 
1               5                   10                  15  


<210>  426
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  426

Gly Ala Ser Tyr Leu Pro Ser 
1               5           


<210>  427
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  427

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  428
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  428

Leu Gly Gly Tyr Asp Gly Asp Ala Asp Thr Tyr Asn Thr 
1               5                   10              


<210>  429
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  429

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  430
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  430

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  431
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  431
gccgtgctga cccagacacc atcgcccgtg tctgcagctg tgggaggcac agtcaccatc     60

aagtgccagt ccagtcagag tgtttataat aacaacctct tatcctggta tcagcagaaa    120

ccagggcagc ctcccaagct cctgatctgg ggtgcatcct atctgccatc tggggtccca    180

gataggttca gcggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtgcag    240

tgtgacgatg ctgccactta ctactgtcta ggcggttatg atggtgatgc tgatacatat    300

aatactttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc    360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg    420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa    480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc    540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa    600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt       657


<210>  432
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  432
gccgtgctga cccagacacc atcgcccgtg tctgcagctg tgggaggcac agtcaccatc     60

aagtgccagt ccagtcagag tgtttataat aacaacctct tatcctggta tcagcagaaa    120

ccagggcagc ctcccaagct cctgatctgg ggtgcatcct atctgccatc tggggtccca    180

gataggttca gcggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtgcag    240

tgtgacgatg ctgccactta ctactgtcta ggcggttatg atggtgatgc tgatacatat    300

aatactttcg gcggagggac cgaggtggtg gtcaaacgt                           339


<210>  433
<211>  66
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  433
gccgtgctga cccagacacc atcgcccgtg tctgcagctg tgggaggcac agtcaccatc     60

aagtgc                                                                66


<210>  434
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  434
cagtccagtc agagtgttta taataacaac ctcttatcc                            39


<210>  435
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  435
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctgg                     45


<210>  436
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  436
ggtgcatcct atctgccatc t                                               21


<210>  437
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  437
ggggtcccag ataggttcag cggcagtgga tctgggacac agttcactct caccatcagc     60

ggcgtgcagt gtgacgatgc tgccacttac tactgt                               96


<210>  438
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  438
ctaggcggtt atgatggtga tgctgataca tataatact                            39


<210>  439
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  439
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  440
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  440
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  441
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  441

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Asn Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Ala 
        35                  40                  45              


Val Ile Tyr Val Val Gly Ala Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val Tyr 
                85                  90                  95      


Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  442
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  442

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Asn Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Ala 
        35                  40                  45              


Val Ile Tyr Val Val Gly Ala Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val Tyr 
                85                  90                  95      


Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  443
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  443

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
            20                  25                  


<210>  444
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  444

Ser Asn Ala Ile Ser 
1               5   


<210>  445
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  445

Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Ile Ala 
1               5                   10                  


<210>  446
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  446

Val Ile Tyr Val Val Gly Ala Thr Asp Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  447
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  447

Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  448
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  448

Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu 
1               5                   10      


<210>  449
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  449

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  450
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  450

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  451
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  451
cagtcgctgg aggagtccgg gggtcgcctg gtaacgcctg gaggatccct gacactcacc     60

tgcacagtct ctggaatcga cctcagtagc aatgcaataa gctgggtccg ccaggctcca    120

gagaaggggc tggagtggat cgcagtcatt tatgttgttg gtgccactga ctacgcgagc    180

tgggcgaaag gccgattcac catctccaga acctcgacca cggtggatct gaaaatgacc    240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagtttatga ttctggctgg    300

aatcacttta acttgtgggg cccaggcacc ctcgtcaccg tctcgagcgc ctccaccaag    360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc    420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc    480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc    540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac    600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac    660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc    720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc    780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc    840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt    900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc    960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg   1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac   1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg   1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac   1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac   1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc   1320

tccctgtctc cgggtaaa                                                 1338


<210>  452
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  452
cagtcgctgg aggagtccgg gggtcgcctg gtaacgcctg gaggatccct gacactcacc     60

tgcacagtct ctggaatcga cctcagtagc aatgcaataa gctgggtccg ccaggctcca    120

gagaaggggc tggagtggat cgcagtcatt tatgttgttg gtgccactga ctacgcgagc    180

tgggcgaaag gccgattcac catctccaga acctcgacca cggtggatct gaaaatgacc    240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagtttatga ttctggctgg    300

aatcacttta acttgtgggg cccaggcacc ctcgtcaccg tctcgagc                 348


<210>  453
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  453
cagtcgctgg aggagtccgg gggtcgcctg gtaacgcctg gaggatccct gacactcacc     60

tgcacagtct ctggaatcga cctcagt                                         87


<210>  454
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  454
agcaatgcaa taagc                                                      15


<210>  455
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  455
tgggtccgcc aggctccaga gaaggggctg gagtggatcg ca                        42


<210>  456
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  456
gtcatttatg ttgttggtgc cactgactac gcgagctggg cgaaaggc                  48


<210>  457
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  457
cgattcacca tctccagaac ctcgaccacg gtggatctga aaatgaccag tctgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  458
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  458
gtttatgatt ctggctggaa tcactttaac ttg                                  33


<210>  459
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  459
tggggcccag gcaccctcgt caccgtctcg agc                                  33


<210>  460
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  460
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  461
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  461

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Val Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Lys Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  462
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  462

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Val Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Lys Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  463
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  463

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  464
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  464

Gln Val Ser Gln Ser Ile Ser Ser Trp Leu Ser 
1               5                   10      


<210>  465
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  465

Trp Tyr Gln Lys Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  466
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  466

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  467
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  467

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  468
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  468

Gln Gln Ala Tyr Ser Val Ser Asn Val Asp Asn Ala 
1               5                   10          


<210>  469
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  469

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  470
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  470

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  471
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  471
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggtcagtca gagcattagt agttggttat cctggtatca gaagaaacca    120

gggcagcgtc ccaagctcct gatctacagg gcatccactc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ctgtcaacag gcttatagtg ttagtaatgt tgataatgct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  472
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  472
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggtcagtca gagcattagt agttggttat cctggtatca gaagaaacca    120

gggcagcgtc ccaagctcct gatctacagg gcatccactc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ctgtcaacag gcttatagtg ttagtaatgt tgataatgct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  473
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  473
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgc                                                             69


<210>  474
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  474
caggtcagtc agagcattag tagttggtta tcc                                  33


<210>  475
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  475
tggtatcaga agaaaccagg gcagcgtccc aagctcctga tctac                     45


<210>  476
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  476
agggcatcca ctctggcatc t                                               21


<210>  477
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  477
ggggtctcat cgcggttcaa aggcagtgga tctgggacag agttcactct caccatcagc     60

ggcgtggagt gtgccgatgc tgccacttac tactgt                               96


<210>  478
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  478
caacaggctt atagtgttag taatgttgat aatgct                               36


<210>  479
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  479
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  480
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  480
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  481
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  481

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Val Val Gly Ala Thr Asp Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  482
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  482

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Val Val Gly Ala Thr Asp Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  483
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  483

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  484
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  484

Ser Asn Ala Ile Ser 
1               5   


<210>  485
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  485

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  486
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  486

Val Ile Tyr Val Val Gly Ala Thr Asp Tyr Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  487
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  487

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  488
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  488

Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu 
1               5                   10      


<210>  489
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  489

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  490
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  490

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  491
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  491
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt agcaatgcaa taagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg ggtcgcagtc atctatgttg ttggtgccac tgactacgcg    180

agcagtgcga aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agtttatgat    300

tctggctgga atcactttaa cttgtggggc caagggaccc tcgtcaccgt ctcgagcgcc    360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa    660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg    720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac    840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc    900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa   1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc   1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg   1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1320

aagagcctct ccctgtctcc gggtaaa                                       1347


<210>  492
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  492
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt agcaatgcaa taagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg ggtcgcagtc atctatgttg ttggtgccac tgactacgcg    180

agcagtgcga aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agtttatgat    300

tctggctgga atcactttaa cttgtggggc caagggaccc tcgtcaccgt ctcgagc       357


<210>  493
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  493
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt                                      90


<210>  494
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  494
agcaatgcaa taagc                                                      15


<210>  495
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  495
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ca                        42


<210>  496
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  496
gtcatctatg ttgttggtgc cactgactac gcgagcagtg cgaaaggc                  48


<210>  497
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  497
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg     60

agagctgagg acactgctgt gtattactgt gctaga                               96


<210>  498
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  498
gtttatgatt ctggctggaa tcactttaac ttg                                  33


<210>  499
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  499
tggggccaag ggaccctcgt caccgtctcg agc                                  33


<210>  500
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  500
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  501
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  501

Asp Tyr Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Val Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  502
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  502

Asp Tyr Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Val Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  503
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  503

Asp Tyr Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  504
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  504

Gln Val Ser Gln Ser Ile Ser Ser Trp Leu Ser 
1               5                   10      


<210>  505
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  505

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  506
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  506

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  507
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  507

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  508
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  508

Gln Gln Ala Tyr Ser Val Ser Asn Val Asp Asn Ala 
1               5                   10          


<210>  509
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  509

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  510
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  510

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  511
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  511
gactatcaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggtcagtca gagcattagt agttggttat cctggtatca gcagaaacca    120

ggaaaagccc ctaagctcct gatctatagg gcatccactc tggcatctgg agtcccatca    180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct    240

gatgattttg caacttatta ctgccaacag gcttatagtg ttagtaatgt tgataatgct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgtacggtgg ctgcaccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  512
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  512
gactatcaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggtcagtca gagcattagt agttggttat cctggtatca gcagaaacca    120

ggaaaagccc ctaagctcct gatctatagg gcatccactc tggcatctgg agtcccatca    180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct    240

gatgattttg caacttatta ctgccaacag gcttatagtg ttagtaatgt tgataatgct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgt                                 333


<210>  513
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  513
gactatcaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgc                                                             69


<210>  514
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  514
caggtcagtc agagcattag tagttggtta tcc                                  33


<210>  515
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  515
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                     45


<210>  516
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  516
agggcatcca ctctggcatc t                                               21


<210>  517
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  517
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc     60

agcctgcagc ctgatgattt tgcaacttat tactgc                               96


<210>  518
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  518
caacaggctt atagtgttag taatgttgat aatgct                               36


<210>  519
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  519
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                  33


<210>  520
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  520
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  521
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  521

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Ser Phe Gly Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Trp Asp 
                85                  90                  95      


Ala Glu Asn Asn Glu Ile Leu Asn Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  522
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  522

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Ser Phe Gly Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Trp Asp 
                85                  90                  95      


Ala Glu Asn Asn Glu Ile Leu Asn Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  523
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  523

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  524
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  524

Asn Tyr Ala Met Thr 
1               5   


<210>  525
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  525

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  526
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  526

Val Ile Ser Phe Gly Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  527
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  527

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  528
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  528

Trp Asp Ala Glu Asn Asn Glu Ile Leu Asn Leu 
1               5                   10      


<210>  529
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  529

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  530
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  530

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  531
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  531
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagtaac tacgcaatga cctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggagtcatt agttttggtg gtaacacata ctacgcgaac    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gatgggatgc tgaaaacaat    300

gagattctta acttgtgggg ccaagggacc ctcgtcaccg tctcgagcgc ctccaccaag    360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc    420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc    480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc    540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac    600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac    660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc    720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc    780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc    840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt    900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc    960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg   1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac   1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg   1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac   1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac   1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc   1320

tccctgtctc cgggtaaa                                                 1338


<210>  532
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  532
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagtaac tacgcaatga cctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggagtcatt agttttggtg gtaacacata ctacgcgaac    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gatgggatgc tgaaaacaat    300

gagattctta acttgtgggg ccaagggacc ctcgtcaccg tctcgagc                 348


<210>  533
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  533
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagt                                         87


<210>  534
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  534
aactacgcaa tgacc                                                      15


<210>  535
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  535
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                        42


<210>  536
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  536
gtcattagtt ttggtggtaa cacatactac gcgaactggg cgaaaggc                  48


<210>  537
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  537
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  538
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  538
tgggatgctg aaaacaatga gattcttaac ttg                                  33


<210>  539
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  539
tggggccaag ggaccctcgt caccgtctcg agc                                  33


<210>  540
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  540
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  541
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  541

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ala Trp Ser Asn 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  542
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  542

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Glu Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ala Trp Ser Asn 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  543
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  543

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  544
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  544

Gln Ala Ser Glu Ser Ile Glu Ser Tyr Leu Ala 
1               5                   10      


<210>  545
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  545

Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  546
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  546

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  547
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  547

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  548
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  548

Gln Gln Gly Asp Ala Trp Ser Asn Val Asp Asn Val 
1               5                   10          


<210>  549
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  549

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  550
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  550

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  551
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  551
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtga gagcattgaa agctatttag cctggtatca gcagaaatca    120

gggcagcctc ccaagctcct gatctacagg gcttccactc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggaatgt    240

gccgatgctg ccacttacta ctgtcaacag ggtgatgctt ggagtaatgt tgataatgtt    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  552
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  552
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtga gagcattgaa agctatttag cctggtatca gcagaaatca    120

gggcagcctc ccaagctcct gatctacagg gcttccactc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggaatgt    240

gccgatgctg ccacttacta ctgtcaacag ggtgatgctt ggagtaatgt tgataatgtt    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  553
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  553
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgc                                                             69


<210>  554
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  554
caggccagtg agagcattga aagctattta gcc                                  33


<210>  555
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  555
tggtatcagc agaaatcagg gcagcctccc aagctcctga tctac                     45


<210>  556
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  556
agggcttcca ctctggcatc t                                               21


<210>  557
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  557
ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc     60

ggcgtggaat gtgccgatgc tgccacttac tactgt                               96


<210>  558
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  558
caacagggtg atgcttggag taatgttgat aatgtt                               36


<210>  559
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  559
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  560
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  560
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  561
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  561

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Ser Phe Gly Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Trp Asp 
                85                  90                  95      


Ala Glu Asn Asn Glu Ile Leu Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  562
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  562

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Ser Phe Gly Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Trp Asp 
                85                  90                  95      


Ala Glu Asn Asn Glu Ile Leu Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  563
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  563

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  564
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  564

Asn Tyr Ala Met Thr 
1               5   


<210>  565
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  565

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  566
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  566

Val Ile Ser Phe Gly Gly Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  567
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  567

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  568
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  568

Trp Asp Ala Glu Asn Asn Glu Ile Leu Asn Leu 
1               5                   10      


<210>  569
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  569

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  570
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  570

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  571
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  571
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagtaac tacgcaatga cctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggagtcatt agttttggtg gtaacacata ctacgcgaac    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gatgggatgc tgaaaacaat    300

gagattctta acttgtgggg cccagggacc ctcgtcaccg tctcgagcgc ctccaccaag    360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc    420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc    480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc    540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac    600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac    660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc    720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc    780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc    840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt    900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc    960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg   1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac   1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg   1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac   1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac   1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc   1320

tccctgtctc cgggtaaa                                                 1338


<210>  572
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  572
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagtaac tacgcaatga cctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggagtcatt agttttggtg gtaacacata ctacgcgaac    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gatgggatgc tgaaaacaat    300

gagattctta acttgtgggg cccagggacc ctcgtcaccg tctcgagc                 348


<210>  573
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  573
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagt                                         87


<210>  574
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  574
aactacgcaa tgacc                                                      15


<210>  575
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  575
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                        42


<210>  576
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  576
gtcattagtt ttggtggtaa cacatactac gcgaactggg cgaaaggc                  48


<210>  577
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  577
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  578
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  578
tgggatgctg aaaacaatga gattcttaac ttg                                  33


<210>  579
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  579
tggggcccag ggaccctcgt caccgtctcg agc                                  33


<210>  580
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  580
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  581
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  581

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ala Trp Ser Asn 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  582
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  582

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ala Trp Ser Asn 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  583
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  583

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  584
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  584

Gln Ala Ser Glu Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  585
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  585

Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  586
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  586

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  587
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  587

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  588
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  588

Gln Gln Gly Asp Ala Trp Ser Asn Val Asp Asn Val 
1               5                   10          


<210>  589
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  589

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  590
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  590

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  591
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  591
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtga gagcattagt agctacttag cctggtatca gcagaaatca    120

gggcagcctc ccaagctcct gatctacagg gcttccactc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ctgtcaacag ggtgatgctt ggagtaatgt tgataatgtt    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  592
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  592
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtga gagcattagt agctacttag cctggtatca gcagaaatca    120

gggcagcctc ccaagctcct gatctacagg gcttccactc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ctgtcaacag ggtgatgctt ggagtaatgt tgataatgtt    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  593
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  593
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgc                                                             69


<210>  594
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  594
caggccagtg agagcattag tagctactta gcc                                  33


<210>  595
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  595
tggtatcagc agaaatcagg gcagcctccc aagctcctga tctac                     45


<210>  596
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  596
agggcttcca ctctggcatc t                                               21


<210>  597
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  597
ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc     60

ggcgtggagt gtgccgatgc tgccacttac tactgt                               96


<210>  598
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  598
caacagggtg atgcttggag taatgttgat aatgtt                               36


<210>  599
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  599
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  600
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  600
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  601
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  601

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Met Ile Gly Val Asn Gly Arg Ala Trp Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Leu Ile 
                85                  90                  95      


Asp Glu Arg Ser Thr Tyr Ser Tyr Val Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  602
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  602

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Met Ile Gly Val Asn Gly Arg Ala Trp Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Leu Ile 
                85                  90                  95      


Asp Glu Arg Ser Thr Tyr Ser Tyr Val Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  603
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  603

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
            20                  25                  


<210>  604
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  604

Asn Tyr Ala Met Gly 
1               5   


<210>  605
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  605

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
1               5                   10                  


<210>  606
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  606

Met Ile Gly Val Asn Gly Arg Ala Trp Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      


<210>  607
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  607

Arg Phe Thr Ile Ser Lys Thr Ser Pro Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  608
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  608

Leu Ile Asp Glu Arg Ser Thr Tyr Ser Tyr Val Phe Asp Leu 
1               5                   10                  


<210>  609
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  609

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  610
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  610

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  611
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  611
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggaatcga cctcagtaat tatgcaatgg gctgggtccg ccaggctcca    120

gggaaggggc tggaatacat cggaatgatt ggtgttaatg gtagggcatg gtacgcgact    180

tgggcgaaag gccgattcac catctccaag acctcgccca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gattgattga cgagcgttca    300

acttatagtt atgtttttga cttgtggggc caaggcaccc tggtcaccgt ctcgagcgcc    360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa    660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg    720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac    840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc    900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa   1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc   1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg   1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1320

aagagcctct ccctgtctcc gggtaaa                                       1347


<210>  612
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  612
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggaatcga cctcagtaat tatgcaatgg gctgggtccg ccaggctcca    120

gggaaggggc tggaatacat cggaatgatt ggtgttaatg gtagggcatg gtacgcgact    180

tgggcgaaag gccgattcac catctccaag acctcgccca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gattgattga cgagcgttca    300

acttatagtt atgtttttga cttgtggggc caaggcaccc tggtcaccgt ctcgagc       357


<210>  613
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  613
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggaatcga cctcagt                                         87


<210>  614
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  614
aattatgcaa tgggc                                                      15


<210>  615
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  615
tgggtccgcc aggctccagg gaaggggctg gaatacatcg ga                        42


<210>  616
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  616
atgattggtg ttaatggtag ggcatggtac gcgacttggg cgaaaggc                  48


<210>  617
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  617
cgattcacca tctccaagac ctcgcccacg gtggatctga aaatcaccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  618
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  618
ttgattgacg agcgttcaac ttatagttat gtttttgact tg                        42


<210>  619
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  619
tggggccaag gcaccctggt caccgtctcg agc                                  33


<210>  620
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  620
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  621
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  621

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Gly Ser Gln Ser Leu Tyr Asn Asn Asn 
            20                  25                  30          


Ala Phe Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys Gly 
                85                  90                  95      


Asp Val Asp Cys Ile Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  622
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  622

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Gly Ser Gln Ser Leu Tyr Asn Asn Asn 
            20                  25                  30          


Ala Phe Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys Gly 
                85                  90                  95      


Asp Val Asp Cys Ile Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  623
<211>  22
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  623

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys 
            20          


<210>  624
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  624

Gln Gly Ser Gln Ser Leu Tyr Asn Asn Asn Ala Phe Ser 
1               5                   10              


<210>  625
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  625

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  626
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  626

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  627
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  627

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  628
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  628

Gln Gly Glu Phe Ser Cys Gly Asp Val Asp Cys Ile Ala 
1               5                   10              


<210>  629
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  629

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  630
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  630

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  631
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  631
caagtgctga cccagactcc atcccctgtg tctgcagctg tgggaggcac agtcaccatc     60

aactgccagg gcagtcagag tctttataat aacaacgcct tttcctggta tcagcagaaa    120

ccagggcagc ctcccaagct cctgatctat gatgcttcca ctctggcgtc tggggtccca    180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag tggcgtgcag    240

tgtgcagatg ctgccactta ctactgtcaa ggcgaattta gttgtggtga tgttgattgt    300

attgctttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc    360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg    420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa    480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc    540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa    600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt       657


<210>  632
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  632
caagtgctga cccagactcc atcccctgtg tctgcagctg tgggaggcac agtcaccatc     60

aactgccagg gcagtcagag tctttataat aacaacgcct tttcctggta tcagcagaaa    120

ccagggcagc ctcccaagct cctgatctat gatgcttcca ctctggcgtc tggggtccca    180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag tggcgtgcag    240

tgtgcagatg ctgccactta ctactgtcaa ggcgaattta gttgtggtga tgttgattgt    300

attgctttcg gcggagggac cgaggtggtg gtcaaacgt                           339


<210>  633
<211>  66
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  633
caagtgctga cccagactcc atcccctgtg tctgcagctg tgggaggcac agtcaccatc     60

aactgc                                                                66


<210>  634
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  634
cagggcagtc agagtcttta taataacaac gccttttcc                            39


<210>  635
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  635
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctat                     45


<210>  636
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  636
gatgcttcca ctctggcgtc t                                               21


<210>  637
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  637
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagt     60

ggcgtgcagt gtgcagatgc tgccacttac tactgt                               96


<210>  638
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  638
caaggcgaat ttagttgtgg tgatgttgat tgtattgct                            39


<210>  639
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  639
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  640
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  640
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  641
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  641

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Pro Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Met Ile Asp Val Ser Gly Ser Thr Tyr Tyr Ala Asp Trp Ala Lys Gly 
    50                  55                  60                  


Arg Leu Thr Ile Ser Lys Thr Pro Thr Thr Val Asp Leu Glu Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Leu Ile 
                85                  90                  95      


Asp Glu Arg Ser Thr Tyr Ser Tyr Ala Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  642
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  642

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Pro Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Met Ile Asp Val Ser Gly Ser Thr Tyr Tyr Ala Asp Trp Ala Lys Gly 
    50                  55                  60                  


Arg Leu Thr Ile Ser Lys Thr Pro Thr Thr Val Asp Leu Glu Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Leu Ile 
                85                  90                  95      


Asp Glu Arg Ser Thr Tyr Ser Tyr Ala Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  643
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  643

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Pro Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
            20                  25                  


<210>  644
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  644

Ser Tyr Ala Met Gly 
1               5   


<210>  645
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  645

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
1               5                   10                  


<210>  646
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  646

Met Ile Asp Val Ser Gly Ser Thr Tyr Tyr Ala Asp Trp Ala Lys Gly 
1               5                   10                  15      


<210>  647
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  647

Arg Leu Thr Ile Ser Lys Thr Pro Thr Thr Val Asp Leu Glu Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  648
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  648

Leu Ile Asp Glu Arg Ser Thr Tyr Ser Tyr Ala Phe Asp Leu 
1               5                   10                  


<210>  649
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  649

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  650
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  650

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  651
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  651
cagtcggtgg aggagtccgg gggtcgcctg gtcccgcctg ggacacccct gacactcacc     60

tgcacagtct ctggaatcga cctcagtagc tatgcaatgg gctgggtccg ccaggctcca    120

gggaaggggc tggaatacat cggaatgatt gatgttagtg gtagcacgta ctacgcggac    180

tgggcgaaag gccgactcac catctccaaa accccgacca cggtggatct ggaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gattgattga cgagcgttca    300

acttatagtt atgcttttga cttgtggggc caaggcaccc tcgtcaccgt ctcgagcgcc    360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa    660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg    720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac    840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc    900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa   1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc   1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg   1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1320

aagagcctct ccctgtctcc gggtaaa                                       1347


<210>  652
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  652
cagtcggtgg aggagtccgg gggtcgcctg gtcccgcctg ggacacccct gacactcacc     60

tgcacagtct ctggaatcga cctcagtagc tatgcaatgg gctgggtccg ccaggctcca    120

gggaaggggc tggaatacat cggaatgatt gatgttagtg gtagcacgta ctacgcggac    180

tgggcgaaag gccgactcac catctccaaa accccgacca cggtggatct ggaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gattgattga cgagcgttca    300

acttatagtt atgcttttga cttgtggggc caaggcaccc tcgtcaccgt ctcgagc       357


<210>  653
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  653
cagtcggtgg aggagtccgg gggtcgcctg gtcccgcctg ggacacccct gacactcacc     60

tgcacagtct ctggaatcga cctcagt                                         87


<210>  654
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  654
agctatgcaa tgggc                                                      15


<210>  655
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  655
tgggtccgcc aggctccagg gaaggggctg gaatacatcg ga                        42


<210>  656
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  656
atgattgatg ttagtggtag cacgtactac gcggactggg cgaaaggc                  48


<210>  657
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  657
cgactcacca tctccaaaac cccgaccacg gtggatctgg aaatcaccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  658
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  658
ttgattgacg agcgttcaac ttatagttat gcttttgact tg                        42


<210>  659
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  659
tggggccaag gcaccctcgt caccgtctcg agc                                  33


<210>  660
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  660
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  661
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  661

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Phe Tyr Asn Asn Gly 
            20                  25                  30          


Ala Phe Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys Gly 
                85                  90                  95      


Ser Ala Asp Cys Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  662
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  662

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Phe Tyr Asn Asn Gly 
            20                  25                  30          


Ala Phe Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Ser Cys Gly 
                85                  90                  95      


Ser Ala Asp Cys Val Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  663
<211>  22
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  663

Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Asn Cys 
            20          


<210>  664
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  664

Gln Ala Ser Gln Ser Phe Tyr Asn Asn Gly Ala Phe Ser 
1               5                   10              


<210>  665
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  665

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  666
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  666

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  667
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  667

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Gln Cys Gly Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  668
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  668

Gln Gly Glu Phe Ser Cys Gly Ser Ala Asp Cys Val Ala 
1               5                   10              


<210>  669
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  669

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  670
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  670

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  671
<211>  657
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  671
caagtgctga cccagactcc atcccctgtg tctgcagctg tgggaggcac agtcaccatc     60

aactgccagg ccagtcagag tttttataat aacggcgcct tttcctggta tcagcagaaa    120

ccagggcagc ctcccaagct cctgatctac gatgcatcca ctctggcatc tggggtccca    180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtacag    240

tgtggagatg ctgccactta ctactgtcaa ggcgaattta gttgtggtag tgctgattgt    300

gttgctttcg gcggagggac cgaggtggtg gtcaaacgta cggtagcggc cccatctgtc    360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg    420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa    480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc    540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa    600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt       657


<210>  672
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  672
caagtgctga cccagactcc atcccctgtg tctgcagctg tgggaggcac agtcaccatc     60

aactgccagg ccagtcagag tttttataat aacggcgcct tttcctggta tcagcagaaa    120

ccagggcagc ctcccaagct cctgatctac gatgcatcca ctctggcatc tggggtccca    180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtacag    240

tgtggagatg ctgccactta ctactgtcaa ggcgaattta gttgtggtag tgctgattgt    300

gttgctttcg gcggagggac cgaggtggtg gtcaaacgt                           339


<210>  673
<211>  66
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  673
caagtgctga cccagactcc atcccctgtg tctgcagctg tgggaggcac agtcaccatc     60

aactgc                                                                66


<210>  674
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  674
caggccagtc agagttttta taataacggc gccttttcc                            39


<210>  675
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  675
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctac                     45


<210>  676
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  676
gatgcatcca ctctggcatc t                                               21


<210>  677
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  677
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc     60

ggcgtacagt gtggagatgc tgccacttac tactgt                               96


<210>  678
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  678
caaggcgaat ttagttgtgg tagtgctgat tgtgttgct                            39


<210>  679
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  679
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  680
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  680
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  681
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  681

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ala Gly Ser Ala Ser Thr Trp Phe Ala Ser Trp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val 
                85                  90                  95      


Gly Tyr Ser Gly Tyr Gly Tyr Asp Asp Asn Leu Asp Met Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  682
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  682

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ala Gly Ser Ala Ser Thr Trp Phe Ala Ser Trp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val 
                85                  90                  95      


Gly Tyr Ser Gly Tyr Gly Tyr Asp Asp Asn Leu Asp Met Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  683
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  683

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  684
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  684

Ser Tyr Asp Met Ser 
1               5   


<210>  685
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  685

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  686
<211>  17
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  686

Ile Ile Tyr Ala Gly Ser Ala Ser Thr Trp Phe Ala Ser Trp Val Lys 
1               5                   10                  15      


Gly 
    


<210>  687
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  687

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  688
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  688

Val Gly Tyr Ser Gly Tyr Gly Tyr Asp Asp Asn Leu Asp Met 
1               5                   10                  


<210>  689
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  689

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  690
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  690

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  691
<211>  1350
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  691
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattctc cctcagcagc tacgacatga gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaatcatt tatgctggta gtgctagcac atggttcgcg    180

agctgggtga aaggccgatt caccatctcc aaaacctcga ccacggtgga tctgaaaatg    240

accagtctga caaccgagga cacggccacc tatttctgtg ccagagtggg ttatagtggt    300

tatggttatg atgataattt ggacatgtgg ggccaaggca ccctcgtcac cgtctcgagc    360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg    420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc   1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag   1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc   1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg   1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg   1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg   1320

cagaagagcc tctccctgtc tccgggtaaa                                    1350


<210>  692
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  692
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattctc cctcagcagc tacgacatga gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaatcatt tatgctggta gtgctagcac atggttcgcg    180

agctgggtga aaggccgatt caccatctcc aaaacctcga ccacggtgga tctgaaaatg    240

accagtctga caaccgagga cacggccacc tatttctgtg ccagagtggg ttatagtggt    300

tatggttatg atgataattt ggacatgtgg ggccaaggca ccctcgtcac cgtctcgagc    360


<210>  693
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  693
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattctc cctcagc                                         87


<210>  694
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  694
agctacgaca tgagc                                                      15


<210>  695
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  695
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                        42


<210>  696
<211>  51
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  696
atcatttatg ctggtagtgc tagcacatgg ttcgcgagct gggtgaaagg c              51


<210>  697
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  697
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatgaccag tctgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  698
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  698
gtgggttata gtggttatgg ttatgatgat aatttggaca tg                        42


<210>  699
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  699
tggggccaag gcaccctcgt caccgtctcg agc                                  33


<210>  700
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  700
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  701
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  701

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys His Gln Gly Tyr Ser Ser Ser Asn 
                85                  90                  95      


Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  702
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  702

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys His Gln Gly Tyr Ser Ser Ser Asn 
                85                  90                  95      


Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  703
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  703

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  704
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  704

Gln Ala Ser Gln Ser Ile Ser Thr Ala Leu Ala 
1               5                   10      


<210>  705
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  705

Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  706
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  706

Asp Ala Ser Lys Leu Ala Ser 
1               5           


<210>  707
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  707

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Ala Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  708
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  708

His Gln Gly Tyr Ser Ser Ser Asn Val Asp Asn Thr 
1               5                   10          


<210>  709
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  709

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  710
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  710

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  711
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  711
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtca gagcattagc actgcattag cctggtatca gcagaaacca    120

gggcagcgtc ccaagctcct gatctacgat gcatcgaaac tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tggggcacag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ctgtcaccag ggttatagta gtagtaatgt tgataatact    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  712
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  712
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtca gagcattagc actgcattag cctggtatca gcagaaacca    120

gggcagcgtc ccaagctcct gatctacgat gcatcgaaac tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tggggcacag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ctgtcaccag ggttatagta gtagtaatgt tgataatact    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  713
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  713
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgc                                                             69


<210>  714
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  714
caggccagtc agagcattag cactgcatta gcc                                  33


<210>  715
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  715
tggtatcagc agaaaccagg gcagcgtccc aagctcctga tctac                     45


<210>  716
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  716
gatgcatcga aactggcatc t                                               21


<210>  717
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  717
ggggtctcat cgcggttcaa aggcagtgga tctggggcac agttcactct caccatcagc     60

ggcgtggagt gtgccgatgc tgccacttac tactgt                               96


<210>  718
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  718
caccagggtt atagtagtag taatgttgat aatact                               36


<210>  719
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  719
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  720
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  720
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  721
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  721

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asn Tyr Trp 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Thr Ile Ser Tyr Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala Thr Val Asn 
                85                  90                  95      


Tyr Pro Asp Tyr Ser Thr Gly Ala Phe Asn Ile Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  722
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  722

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asn Tyr Trp 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Thr Ile Ser Tyr Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala Thr Val Asn 
                85                  90                  95      


Tyr Pro Asp Tyr Ser Thr Gly Ala Phe Asn Ile Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  723
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  723

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  724
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  724

Asn Tyr Trp Met Gly 
1               5   


<210>  725
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  725

Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  726
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  726

Thr Ile Ser Tyr Asp Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  727
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  727

Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala Thr 
            20                  25                  30  


<210>  728
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  728

Val Asn Tyr Pro Asp Tyr Ser Thr Gly Ala Phe Asn Ile 
1               5                   10              


<210>  729
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  729

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  730
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  730

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  731
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  731
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattctc cctcagtaat tattggatgg gctgggtccg ccaggctcca    120

ggggaggggc tggaatggat cggaaccatt agttatgatg gtaacacata ctacgcgagc    180

tgggcaaaag gccgcttcac catctcccga acctcgacca cggtggatct gaaaatgacc    240

agtctgacga ccgaggacac ggccatctat ttctgtgcca cagtcaatta tcctgattat    300

agtactggtg cctttaacat ctggggccca ggcaccctcg tcaccgtctc gagcgcctcc    360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca    420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac    480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc    540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc    600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct    660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca    720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc    780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg    840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta cgccagcacg    900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac    960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc   1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc   1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg   1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac   1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag   1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag   1320

agcctctccc tgtctccggg taaa                                          1344


<210>  732
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  732
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattctc cctcagtaat tattggatgg gctgggtccg ccaggctcca    120

ggggaggggc tggaatggat cggaaccatt agttatgatg gtaacacata ctacgcgagc    180

tgggcaaaag gccgcttcac catctcccga acctcgacca cggtggatct gaaaatgacc    240

agtctgacga ccgaggacac ggccatctat ttctgtgcca cagtcaatta tcctgattat    300

agtactggtg cctttaacat ctggggccca ggcaccctcg tcaccgtctc gagc          354


<210>  733
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  733
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattctc cctcagt                                         87


<210>  734
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  734
aattattgga tgggc                                                      15


<210>  735
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  735
tgggtccgcc aggctccagg ggaggggctg gaatggatcg ga                        42


<210>  736
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  736
accattagtt atgatggtaa cacatactac gcgagctggg caaaaggc                  48


<210>  737
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  737
cgcttcacca tctcccgaac ctcgaccacg gtggatctga aaatgaccag tctgacgacc     60

gaggacacgg ccatctattt ctgtgccaca                                      90


<210>  738
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  738
gtcaattatc ctgattatag tactggtgcc tttaacatc                            39


<210>  739
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  739
tggggcccag gcaccctcgt caccgtctcg agc                                  33


<210>  740
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  740
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  741
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  741

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Asp Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Phe Thr Ala Tyr Tyr Ser Thr 
                85                  90                  95      


Tyr Ile Gly Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  742
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  742

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Asp Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Phe Thr Ala Tyr Tyr Ser Thr 
                85                  90                  95      


Tyr Ile Gly Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  743
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  743

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  744
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  744

Gln Ala Ser Gln Ser Ile Asp Asn Tyr Leu Ala 
1               5                   10      


<210>  745
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  745

Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  746
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  746

Tyr Thr Ser Thr Leu Ala Ser 
1               5           


<210>  747
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  747

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  748
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  748

Gln Phe Thr Ala Tyr Tyr Ser Thr Tyr Ile Gly Ala 
1               5                   10          


<210>  749
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  749

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  750
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  750

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  751
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  751
gatgttgtga tgacccagac tccagcctcc gtgtctgaac ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtca gagcattgat aactacttag cctggtatca gcagaaacca    120

gggcagcgtc ccaggctcct gatctattat acatccactc tggcatctgg ggtcccatcg    180

cggttcaaag gcagtggatc tgggacagag tacactctca ccatcagcga cctggagtgt    240

gccgatgctg ccacttacta ctgtcaattt actgcttatt atagtactta tattggagct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  752
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  752
gatgttgtga tgacccagac tccagcctcc gtgtctgaac ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtca gagcattgat aactacttag cctggtatca gcagaaacca    120

gggcagcgtc ccaggctcct gatctattat acatccactc tggcatctgg ggtcccatcg    180

cggttcaaag gcagtggatc tgggacagag tacactctca ccatcagcga cctggagtgt    240

gccgatgctg ccacttacta ctgtcaattt actgcttatt atagtactta tattggagct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  753
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  753
gatgttgtga tgacccagac tccagcctcc gtgtctgaac ctgtgggagg cacagtcacc     60

atcaagtgc                                                             69


<210>  754
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  754
caggccagtc agagcattga taactactta gcc                                  33


<210>  755
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  755
tggtatcagc agaaaccagg gcagcgtccc aggctcctga tctat                     45


<210>  756
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  756
tatacatcca ctctggcatc t                                               21


<210>  757
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  757
ggggtcccat cgcggttcaa aggcagtgga tctgggacag agtacactct caccatcagc     60

gacctggagt gtgccgatgc tgccacttac tactgt                               96


<210>  758
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  758
caatttactg cttattatag tacttatatt ggagct                               36


<210>  759
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  759
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  760
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  760
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  761
<211>  451
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  761

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Tyr 
            20                  25                  30          


Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Ser Tyr Asp Gly Asn Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Val Asn Tyr Pro Asp Tyr Ser Thr Gly Ala Phe Asn Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  762
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  762

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Tyr 
            20                  25                  30          


Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Ser Tyr Asp Gly Asn Thr Tyr Tyr Ala Ser Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Val Asn Tyr Pro Asp Tyr Ser Thr Gly Ala Phe Asn Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  763
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  763

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  764
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  764

Asn Tyr Trp Met Gly 
1               5   


<210>  765
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  765

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  766
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  766

Thr Ile Ser Tyr Asp Gly Asn Thr Tyr Tyr Ala Ser Ser Ala Lys Gly 
1               5                   10                  15      


<210>  767
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  767

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  768
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  768

Val Asn Tyr Pro Asp Tyr Ser Thr Gly Ala Phe Asn Ile 
1               5                   10              


<210>  769
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  769

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  770
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  770

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  771
<211>  1353
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  771
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt aactattgga tgggctgggt ccgtcaggct    120

ccagggaagg ggctggagtg gatcggaacc attagttatg atggtaacac atactacgcg    180

agcagcgcaa aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctac agtcaattat    300

cctgattata gtactggtgc ctttaacatc tggggccaag ggaccctcgt caccgtctcg    360

agcgcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct    420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg    480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc    540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag    600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag    660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg    720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc    780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac    840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac    900

gccagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc    960

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc   1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag   1080

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac   1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc   1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg   1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac   1320

acgcagaaga gcctctccct gtctccgggt aaa                                1353


<210>  772
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  772
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt aactattgga tgggctgggt ccgtcaggct    120

ccagggaagg ggctggagtg gatcggaacc attagttatg atggtaacac atactacgcg    180

agcagcgcaa aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctac agtcaattat    300

cctgattata gtactggtgc ctttaacatc tggggccaag ggaccctcgt caccgtctcg    360

agc                                                                  363


<210>  773
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  773
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt                                      90


<210>  774
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  774
aactattgga tgggc                                                      15


<210>  775
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  775
tgggtccgtc aggctccagg gaaggggctg gagtggatcg ga                        42


<210>  776
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  776
accattagtt atgatggtaa cacatactac gcgagcagcg caaaaggc                  48


<210>  777
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  777
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg     60

agagctgagg acactgctgt gtattactgt gctaca                               96


<210>  778
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  778
gtcaattatc ctgattatag tactggtgcc tttaacatc                            39


<210>  779
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  779
tggggccaag ggaccctcgt caccgtctcg agc                                  33


<210>  780
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  780
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  781
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  781

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Phe Thr Ala Tyr Tyr Ser Thr 
                85                  90                  95      


Tyr Ile Gly Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  782
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  782

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asp Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Phe Thr Ala Tyr Tyr Ser Thr 
                85                  90                  95      


Tyr Ile Gly Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  783
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  783

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  784
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  784

Gln Ala Ser Gln Ser Ile Asp Asn Tyr Leu Ala 
1               5                   10      


<210>  785
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  785

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  786
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  786

Tyr Thr Ser Thr Leu Ala Ser 
1               5           


<210>  787
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  787

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  788
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  788

Gln Phe Thr Ala Tyr Tyr Ser Thr Tyr Ile Gly Ala 
1               5                   10          


<210>  789
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  789

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  790
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  790

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  791
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  791
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggccagtca gagcattgat aactacttag cctggtatca gcagaaacca    120

gggaaagttc ctaagctcct gatctattat acatccactc tggcatctgg ggtcccatct    180

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagatgttg caacttatta ctgtcaattc actgcttatt atagtactta cattggagct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgtacggtgg ctgcaccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  792
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  792
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggccagtca gagcattgat aactacttag cctggtatca gcagaaacca    120

gggaaagttc ctaagctcct gatctattat acatccactc tggcatctgg ggtcccatct    180

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagatgttg caacttatta ctgtcaattc actgcttatt atagtactta cattggagct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgt                                 333


<210>  793
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  793
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgc                                                             69


<210>  794
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  794
caggccagtc agagcattga taactactta gcc                                  33


<210>  795
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  795
tggtatcagc agaaaccagg gaaagttcct aagctcctga tctat                     45


<210>  796
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  796
tatacatcca ctctggcatc t                                               21


<210>  797
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  797
ggggtcccat ctcgtttcag tggcagtgga tctgggacag atttcactct caccatcagc     60

agcctgcagc ctgaagatgt tgcaacttat tactgt                               96


<210>  798
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  798
caattcactg cttattatag tacttacatt ggagct                               36


<210>  799
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  799
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                  33


<210>  800
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  800
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  801
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  801

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Val Ser Gly Ile Thr Asp Tyr Ala Arg Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg His Ile 
                85                  90                  95      


Asp Ser Ser Gly Trp Asp Gly Leu Gly Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  802
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  802

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Val Ser Gly Ile Thr Asp Tyr Ala Arg Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg His Ile 
                85                  90                  95      


Asp Ser Ser Gly Trp Asp Gly Leu Gly Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  803
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  803

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  804
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  804

Thr Tyr Tyr Met Ser 
1               5   


<210>  805
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  805

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  806
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  806

Ile Ile Tyr Val Ser Gly Ile Thr Asp Tyr Ala Arg Trp Ala Lys Gly 
1               5                   10                  15      


<210>  807
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  807

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  808
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  808

His Ile Asp Ser Ser Gly Trp Asp Gly Leu Gly Ile 
1               5                   10          


<210>  809
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  809

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  810
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  810

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  811
<211>  1341
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  811
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcaccgtct ctggattctc cctcagtacc tactacatga gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaatcatt tatgttagtg gtatcacgga ctacgcgagg    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatgacc    240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gacatattga tagtagtggc    300

tgggatggac tgggcatctg gggccaaggc accctcgtca ccgtctcgag cgcctccacc    360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg    420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac    540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc    600

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt    660

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc    720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca    780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac    840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac    900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag    960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa   1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag   1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag   1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc   1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg   1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc   1320

ctctccctgt ctccgggtaa a                                             1341


<210>  812
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  812
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcaccgtct ctggattctc cctcagtacc tactacatga gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaatcatt tatgttagtg gtatcacgga ctacgcgagg    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatgacc    240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gacatattga tagtagtggc    300

tgggatggac tgggcatctg gggccaaggc accctcgtca ccgtctcgag c             351


<210>  813
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  813
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcaccgtct ctggattctc cctcagt                                         87


<210>  814
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  814
acctactaca tgagc                                                      15


<210>  815
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  815
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                        42


<210>  816
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  816
atcatttatg ttagtggtat cacggactac gcgaggtggg cgaaaggc                  48


<210>  817
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  817
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatgaccag tctgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  818
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  818
catattgata gtagtggctg ggatggactg ggcatc                               36


<210>  819
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  819
tggggccaag gcaccctcgt caccgtctcg agc                                  33


<210>  820
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  820
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  821
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  821

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Thr Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Gly Tyr Ser Asp 
                85                  90                  95      


Thr Asp Asn Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  822
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  822

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Thr Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Gly Tyr Ser Asp 
                85                  90                  95      


Thr Asp Asn Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  823
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  823

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  824
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  824

Gln Ala Ser Glu Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  825
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  825

Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  826
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  826

Arg Ala Ser Thr Leu Thr Ser 
1               5           


<210>  827
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  827

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  828
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  828

Gln Gln Thr Tyr Gly Tyr Ser Asp Thr Asp Asn Ser 
1               5                   10          


<210>  829
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  829

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  830
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  830

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  831
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  831
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtga gagcattagt agctacttaa actggtatca gcagaaacta    120

gggcagcctc ccaagctcct gatctacagg gcatccactc tgacatctgg ggtctcatca    180

aggttcaaag gcagtggatc tgggacagag tacactctca ccatcagcga cctggagtgt    240

gccgatgctg ccacttacta ctgtcagcag acttatggtt atagtgatac tgataattct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  832
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  832
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtga gagcattagt agctacttaa actggtatca gcagaaacta    120

gggcagcctc ccaagctcct gatctacagg gcatccactc tgacatctgg ggtctcatca    180

aggttcaaag gcagtggatc tgggacagag tacactctca ccatcagcga cctggagtgt    240

gccgatgctg ccacttacta ctgtcagcag acttatggtt atagtgatac tgataattct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  833
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  833
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgc                                                             69


<210>  834
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  834
caggccagtg agagcattag tagctactta aac                                  33


<210>  835
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  835
tggtatcagc agaaactagg gcagcctccc aagctcctga tctac                     45


<210>  836
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  836
agggcatcca ctctgacatc t                                               21


<210>  837
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  837
ggggtctcat caaggttcaa aggcagtgga tctgggacag agtacactct caccatcagc     60

gacctggagt gtgccgatgc tgccacttac tactgt                               96


<210>  838
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  838
cagcagactt atggttatag tgatactgat aattct                               36


<210>  839
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  839
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  840
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  840
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  841
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  841

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Gly Arg Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Thr His Gly Val Asn Pro Asp Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Pro Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val 
                85                  90                  95      


Gly Gly Phe Asn Asp Tyr Ser Asp Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  842
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  842

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Gly Arg Tyr Tyr 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Thr His Gly Val Asn Pro Asp Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Pro Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val 
                85                  90                  95      


Gly Gly Phe Asn Asp Tyr Ser Asp Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  843
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  843

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Gly 
            20                  25                  


<210>  844
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  844

Arg Tyr Tyr Met Ser 
1               5   


<210>  845
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  845

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  846
<211>  17
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  846

Ile Ile Tyr Thr His Gly Val Asn Pro Asp Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  847
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  847

Arg Phe Thr Ile Ser Arg Pro Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  848
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  848

Val Gly Gly Phe Asn Asp Tyr Ser Asp Ile 
1               5                   10  


<210>  849
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  849

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  850
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  850

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  851
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  851
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattcac tatcggtcgc tactacatga gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaatcatt tatactcatg gtgttaaccc agactacgcg    180

agctgggcga aaggccgatt caccatctcc agaccctcga ccacggtgga tctgaaaatc    240

accagtccga caaccgagga cacggccacc tatttctgtg ccagagtggg tggttttaat    300

gactactctg acatttgggg cccaggcacc ctggtcaccg tctcgagcgc ctccaccaag    360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc    420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc    480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc    540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac    600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac    660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc    720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc    780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc    840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt    900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc    960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg   1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac   1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg   1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac   1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac   1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc   1320

tccctgtctc cgggtaaa                                                 1338


<210>  852
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  852
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattcac tatcggtcgc tactacatga gctgggtccg ccaggctcca    120

gggaaggggc tggaatggat cggaatcatt tatactcatg gtgttaaccc agactacgcg    180

agctgggcga aaggccgatt caccatctcc agaccctcga ccacggtgga tctgaaaatc    240

accagtccga caaccgagga cacggccacc tatttctgtg ccagagtggg tggttttaat    300

gactactctg acatttgggg cccaggcacc ctggtcaccg tctcgagc                 348


<210>  853
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  853
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattcac tatcggt                                         87


<210>  854
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  854
cgctactaca tgagc                                                      15


<210>  855
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  855
tgggtccgcc aggctccagg gaaggggctg gaatggatcg ga                        42


<210>  856
<211>  51
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  856
atcatttata ctcatggtgt taacccagac tacgcgagct gggcgaaagg c              51


<210>  857
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  857
cgattcacca tctccagacc ctcgaccacg gtggatctga aaatcaccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  858
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  858
gtgggtggtt ttaatgacta ctctgacatt                                      30


<210>  859
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  859
tggggcccag gcaccctggt caccgtctcg agc                                  33


<210>  860
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  860
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  861
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  861

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Tyr Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  862
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  862

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Tyr Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  863
<211>  23
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  863

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  864
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  864

Gln Ala Ser Glu Ser Ile Ser Thr Tyr Leu Ala 
1               5                   10      


<210>  865
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  865

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  866
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  866

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  867
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  867

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  868
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  868

Gln Gln Gly Tyr Ser Tyr Ser Asn Val Asp Asn Ala 
1               5                   10          


<210>  869
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  869

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  870
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  870

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  871
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  871
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtga gagcattagt acctacttag cctggtatca gcagaaacca    120

gggcagcctc ccaagctcct gatctacagg gcatccactc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ctgtcaacag ggttatagtt atagtaatgt tgataatgct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgtacggtag cggccccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  872
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  872
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgcc aggccagtga gagcattagt acctacttag cctggtatca gcagaaacca    120

gggcagcctc ccaagctcct gatctacagg gcatccactc tggcatctgg ggtctcatcg    180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt    240

gccgatgctg ccacttacta ctgtcaacag ggttatagtt atagtaatgt tgataatgct    300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                 333


<210>  873
<211>  69
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  873
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc     60

atcaagtgc                                                             69


<210>  874
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  874
caggccagtg agagcattag tacctactta gcc                                  33


<210>  875
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  875
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctac                     45


<210>  876
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  876
agggcatcca ctctggcatc t                                               21


<210>  877
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  877
ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc     60

ggcgtggagt gtgccgatgc tgccacttac tactgt                               96


<210>  878
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  878
caacagggtt atagttatag taatgttgat aatgct                               36


<210>  879
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  879
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  880
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  880
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  881
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  881

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Gly Arg Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Thr His Gly Val Asn Pro Asp Tyr Ala Ser Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Phe Asn Asp Tyr Ser Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  882
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  882

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Gly Arg Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Thr His Gly Val Asn Pro Asp Tyr Ala Ser Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Phe Asn Asp Tyr Ser Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  883
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  883

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Gly 
            20                  25                  30  


<210>  884
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  884

Arg Tyr Tyr Met Ser 
1               5   


<210>  885
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  885

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  886
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  886

Ile Ile Tyr Thr His Gly Val Asn Pro Asp Tyr Ala Ser Ser Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  887
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  887

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  888
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  888

Val Gly Gly Phe Asn Asp Tyr Ser Asp Ile 
1               5                   10  


<210>  889
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  889

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  890
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  890

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  891
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  891
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcggt cgctactaca tgagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg gatcggaatc atctatactc atggtgttaa cccagactac    180

gcgagcagcg cgaaaggccg attcaccatc tccagagaca attccaagaa caccctgtat    240

cttcaaatga acagcctgag agctgaggac actgctgtgt attactgtgc tagagtgggt    300

ggtttcaatg actactctga catttggggc caagggaccc tcgtcaccgt ctcgagcgcc    360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa    660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg    720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac    840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc    900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa   1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc   1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg   1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1320

aagagcctct ccctgtctcc gggtaaa                                       1347


<210>  892
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  892
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcggt cgctactaca tgagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg gatcggaatc atctatactc atggtgttaa cccagactac    180

gcgagcagcg cgaaaggccg attcaccatc tccagagaca attccaagaa caccctgtat    240

cttcaaatga acagcctgag agctgaggac actgctgtgt attactgtgc tagagtgggt    300

ggtttcaatg actactctga catttggggc caagggaccc tcgtcaccgt ctcgagc       357


<210>  893
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  893
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcggt                                      90


<210>  894
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  894
cgctactaca tgagc                                                      15


<210>  895
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  895
tgggtccgtc aggctccagg gaaggggctg gagtggatcg ga                        42


<210>  896
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  896
atcatctata ctcatggtgt taacccagac tacgcgagca gcgcgaaagg c              51


<210>  897
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  897
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg     60

agagctgagg acactgctgt gtattactgt gctaga                               96


<210>  898
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  898
gtgggtggtt tcaatgacta ctctgacatt                                      30


<210>  899
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  899
tggggccaag ggaccctcgt caccgtctcg agc                                  33


<210>  900
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  900
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  901
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  901

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Tyr Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  902
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  902

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Tyr Ser Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  903
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  903

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  904
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  904

Gln Ala Ser Glu Ser Ile Ser Thr Tyr Leu Ala 
1               5                   10      


<210>  905
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  905

Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  906
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  906

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  907
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  907

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  908
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  908

Gln Gln Gly Tyr Ser Tyr Ser Asn Val Asp Asn Ala 
1               5                   10          


<210>  909
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  909

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  910
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  910

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  911
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  911
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggccagtga gagcattagt acctacttag cctggtatca gcagaaacca    120

gggaaagttc ctaagctcct gatctatagg gcatccactc tggcatctgg ggtcccatct    180

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagatgttg caacttatta ctgtcaacag ggttatagtt atagtaatgt tgataatgct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgtacggtgg ctgcaccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  912
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  912
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggccagtga gagcattagt acctacttag cctggtatca gcagaaacca    120

gggaaagttc ctaagctcct gatctatagg gcatccactc tggcatctgg ggtcccatct    180

cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagatgttg caacttatta ctgtcaacag ggttatagtt atagtaatgt tgataatgct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgt                                 333


<210>  913
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  913
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgc                                                             69


<210>  914
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  914
caggccagtg agagcattag tacctactta gcc                                  33


<210>  915
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  915
tggtatcagc agaaaccagg gaaagttcct aagctcctga tctat                     45


<210>  916
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  916
agggcatcca ctctggcatc t                                               21


<210>  917
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  917
ggggtcccat ctcgtttcag tggcagtgga tctgggacag atttcactct caccatcagc     60

agcctgcagc ctgaagatgt tgcaacttat tactgt                               96


<210>  918
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  918
caacagggtt atagttatag taatgttgat aatgct                               36


<210>  919
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  919
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                  33


<210>  920
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  920
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  921
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  921

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 
        35                  40                  45              


Tyr Ile Phe Ala Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Glu Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ser 
                85                  90                  95      


Gly Ala Arg Phe Phe Pro Asn Tyr Phe Ala Ile Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  922
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  922

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 
        35                  40                  45              


Tyr Ile Phe Ala Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Glu Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ser 
                85                  90                  95      


Gly Ala Arg Phe Phe Pro Asn Tyr Phe Ala Ile Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  923
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  923

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  924
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  924

Ser Tyr Ala Met Gly 
1               5   


<210>  925
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  925

Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 
1               5                   10                  


<210>  926
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  926

Tyr Ile Phe Ala Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  927
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  927

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Glu Leu Lys Ile Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  928
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  928

Gly Ser Gly Ala Arg Phe Phe Pro Asn Tyr Phe Ala Ile 
1               5                   10              


<210>  929
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  929

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  930
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  930

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  931
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  931
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattctc cctcagtagc tatgcaatgg gctggttccg ccaggctcca    120

gggaaggggc tggagtggat cgcatacatt tttgctagtg gtagcacata ctacgcgagc    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggagct gaaaatcacc    240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gaggtagtgg tgctcgtttt    300

ttccccaact actttgccat ctggggccca ggcaccctcg tcaccgtctc gagcgcctcc    360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca    420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac    480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc    540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc    600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct    660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca    720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc    780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg    840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta cgccagcacg    900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac    960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc   1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc   1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg   1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac   1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag   1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag   1320

agcctctccc tgtctccggg taaa                                          1344


<210>  932
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  932
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattctc cctcagtagc tatgcaatgg gctggttccg ccaggctcca    120

gggaaggggc tggagtggat cgcatacatt tttgctagtg gtagcacata ctacgcgagc    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggagct gaaaatcacc    240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gaggtagtgg tgctcgtttt    300

ttccccaact actttgccat ctggggccca ggcaccctcg tcaccgtctc gagc          354


<210>  933
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  933
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagcct ctggattctc cctcagt                                         87


<210>  934
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  934
agctatgcaa tgggc                                                      15


<210>  935
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  935
tggttccgcc aggctccagg gaaggggctg gagtggatcg ca                        42


<210>  936
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  936
tacatttttg ctagtggtag cacatactac gcgagctggg cgaaaggc                  48


<210>  937
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  937
cgattcacca tctccaaaac ctcgaccacg gtggagctga aaatcaccag tctgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  938
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  938
ggtagtggtg ctcgtttttt ccccaactac tttgccatc                            39


<210>  939
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  939
tggggcccag gcaccctcgt caccgtctcg agc                                  33


<210>  940
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  940
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  941
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  941

Gln Val Leu Thr Gln Thr Ala Ser Ser Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Thr Asn Asn Asn 
            20                  25                  30          


Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Ser Gly Gly 
                85                  90                  95      


Ile Cys Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  942
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  942

Gln Val Leu Thr Gln Thr Ala Ser Ser Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Thr Asn Asn Asn 
            20                  25                  30          


Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Ser Gly Gly 
                85                  90                  95      


Ile Cys Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110 


<210>  943
<211>  22
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  943

Gln Val Leu Thr Gln Thr Ala Ser Ser Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys 
            20          


<210>  944
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  944

Gln Ser Ser Gln Ser Val Thr Asn Asn Asn Asp Leu Ala 
1               5                   10              


<210>  945
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  945

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  946
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  946

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  947
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  947

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  948
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  948

Gln Gly Ser Tyr Ser Gly Gly Ile Cys Ala 
1               5                   10  


<210>  949
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  949

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  950
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  950

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  951
<211>  648
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  951
caagtgctga cccagactgc atcgtccgtg tctgcagctg tgggaggcac agtcaccatc     60

agttgccagt ccagtcagag tgttactaat aacaacgact tagcctggta tcagcagaaa    120

ccagggcagc ctcccaagct cctgatctac caggcatcca aactggcatc tggggtccca    180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag    240

tgtgacgatg ctgccactta ctactgtcaa ggcagttata gtggtggtat ttgtgctttc    300

ggcggaggga ccgaggtggt ggtcaaacgt acggtagcgg ccccatctgt cttcatcttc    360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 648


<210>  952
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  952
caagtgctga cccagactgc atcgtccgtg tctgcagctg tgggaggcac agtcaccatc     60

agttgccagt ccagtcagag tgttactaat aacaacgact tagcctggta tcagcagaaa    120

ccagggcagc ctcccaagct cctgatctac caggcatcca aactggcatc tggggtccca    180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag    240

tgtgacgatg ctgccactta ctactgtcaa ggcagttata gtggtggtat ttgtgctttc    300

ggcggaggga ccgaggtggt ggtcaaacgt                                     330


<210>  953
<211>  66
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  953
caagtgctga cccagactgc atcgtccgtg tctgcagctg tgggaggcac agtcaccatc     60

agttgc                                                                66


<210>  954
<211>  39
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  954
cagtccagtc agagtgttac taataacaac gacttagcc                            39


<210>  955
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  955
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctac                     45


<210>  956
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  956
caggcatcca aactggcatc t                                               21


<210>  957
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  957
ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc     60

gacctggagt gtgacgatgc tgccacttac tactgt                               96


<210>  958
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  958
caaggcagtt atagtggtgg tatttgtgct                                      30


<210>  959
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  959
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  960
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  960
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  961
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  961

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Thr 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Phe Ile Ser Ser Ser Ser Ser Ile Asp Tyr Val Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Phe 
                85                  90                  95      


Tyr Ala Asp Tyr Ile Gly Gly Gly Tyr Pro Tyr Ile Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  962
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  962

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Thr 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Phe Ile Ser Ser Ser Ser Ser Ile Asp Tyr Val Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Phe 
                85                  90                  95      


Tyr Ala Asp Tyr Ile Gly Gly Gly Tyr Pro Tyr Ile Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  963
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  963

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  964
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  964

Thr Tyr Thr Met Asn 
1               5   


<210>  965
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  965

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
1               5                   10                  


<210>  966
<211>  16
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  966

Phe Ile Ser Ser Ser Ser Ser Ile Asp Tyr Val Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  967
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  967

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  968
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  968

Asp Phe Tyr Ala Asp Tyr Ile Gly Gly Gly Tyr Pro Tyr Ile 
1               5                   10                  


<210>  969
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  969

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  970
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  970

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  971
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  971
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagtacc tatacaatga actgggtccg ccaggctcca    120

gggaaggggc tggaatacat cggattcatt agtagtagta gtagcataga ttatgtgagt    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagattttta tgctgattat    300

attggtggtg gttatcctta catctggggc ccgggcaccc tcgtcaccgt ctcgagcgcc    360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa    660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg    720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac    840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc    900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa   1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc   1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg   1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1320

aagagcctct ccctgtctcc gggtaaa                                       1347


<210>  972
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  972
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagtacc tatacaatga actgggtccg ccaggctcca    120

gggaaggggc tggaatacat cggattcatt agtagtagta gtagcataga ttatgtgagt    180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc    240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagattttta tgctgattat    300

attggtggtg gttatcctta catctggggc ccgggcaccc tcgtcaccgt ctcgagc       357


<210>  973
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  973
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc     60

tgcacagtct ctggattctc cctcagt                                         87


<210>  974
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  974
acctatacaa tgaac                                                      15


<210>  975
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  975
tgggtccgcc aggctccagg gaaggggctg gaatacatcg ga                        42


<210>  976
<211>  48
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  976
ttcattagta gtagtagtag catagattat gtgagttggg cgaaaggc                  48


<210>  977
<211>  90
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  977
cgattcacca tctccaaaac ctcgaccacg gtggatctga aaatcaccag tccgacaacc     60

gaggacacgg ccacctattt ctgtgccaga                                      90


<210>  978
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  978
gatttttatg ctgattatat tggtggtggt tatccttaca tc                        42


<210>  979
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  979
tggggcccgg gcaccctcgt caccgtctcg agc                                  33


<210>  980
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  980
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  981
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  981

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Asn Tyr Asp Ile Tyr 
                85                  90                  95      


Ser Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  982
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  982

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Asn Tyr Asp Ile Tyr 
                85                  90                  95      


Ser Tyr Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110 


<210>  983
<211>  24
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  983

Ala Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys 
            20                  


<210>  984
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  984

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  985
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  985

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  986
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  986

Gly Ala Ser Lys Leu Thr Ser 
1               5           


<210>  987
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  987

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  988
<211>  10
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  988

Gln Ser Asn Tyr Asp Ile Tyr Ser Tyr Ala 
1               5                   10  


<210>  989
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  989

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  990
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  990

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  991
<211>  648
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  991
gccgatgttg tgatgaccca gactccagcc tccgtgtctg aacctgtggg aggcacagtc     60

accatcaagt gccaggccag tcagagcatt agtagctact tatcctggta tcagcagaaa    120

ccagggcagc ctcccaagct cctgatctat ggtgcatcca aactgacatc tggggtccca    180

tcgcggttca aaggcagtgg atctgggaca gagtacactc tcaccatcag cgacctggag    240

tgtgccgatg ctgccactta ctactgtcaa agcaattatg atatttatag ttatgctttc    300

ggcggaggga ccgaggtggt ggtcaaacgt acggtagcgg ccccatctgt cttcatcttc    360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 648


<210>  992
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  992
gccgatgttg tgatgaccca gactccagcc tccgtgtctg aacctgtggg aggcacagtc     60

accatcaagt gccaggccag tcagagcatt agtagctact tatcctggta tcagcagaaa    120

ccagggcagc ctcccaagct cctgatctat ggtgcatcca aactgacatc tggggtccca    180

tcgcggttca aaggcagtgg atctgggaca gagtacactc tcaccatcag cgacctggag    240

tgtgccgatg ctgccactta ctactgtcaa agcaattatg atatttatag ttatgctttc    300

ggcggaggga ccgaggtggt ggtcaaacgt                                     330


<210>  993
<211>  72
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  993
gccgatgttg tgatgaccca gactccagcc tccgtgtctg aacctgtggg aggcacagtc     60

accatcaagt gc                                                         72


<210>  994
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  994
caggccagtc agagcattag tagctactta tcc                                  33


<210>  995
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  995
tggtatcagc agaaaccagg gcagcctccc aagctcctga tctat                     45


<210>  996
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  996
ggtgcatcca aactgacatc t                                               21


<210>  997
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  997
ggggtcccat cgcggttcaa aggcagtgga tctgggacag agtacactct caccatcagc     60

gacctggagt gtgccgatgc tgccacttac tactgt                               96


<210>  998
<211>  30
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  998
caaagcaatt atgatattta tagttatgct                                      30


<210>  999
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  999
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  1000
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1000
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  1001
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1001

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Asp Asp His 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Ile 
        35                  40                  45              


Ala Cys Met Tyr Val Gly Ser Ser Gly Ala Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Asp Trp Thr Ser Tyr Tyr Ala Trp Gly Tyr Trp Ala Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  1002
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1002

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Asp Asp His 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Ile 
        35                  40                  45              


Ala Cys Met Tyr Val Gly Ser Ser Gly Ala Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Asp Trp Thr Ser Tyr Tyr Ala Trp Gly Tyr Trp Ala Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  1003
<211>  29
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1003

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser 
            20                  25                  


<210>  1004
<211>  6
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1004

Asp Asp His Tyr Met Cys 
1               5       


<210>  1005
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1005

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Ile Ala 
1               5                   10                  


<210>  1006
<211>  18
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1006

Cys Met Tyr Val Gly Ser Ser Gly Ala Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  1007
<211>  31
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1007

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu Gln Met 
1               5                   10                  15      


Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  1008
<211>  14
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1008

Asp Asp Trp Thr Ser Tyr Tyr Ala Trp Gly Tyr Trp Ala Leu 
1               5                   10                  


<210>  1009
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1009

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  1010
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1010

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1011
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1011
cagtcgttgg aggagtccgg gggagacctg gtcaagcctg gaggaaccct gacactcacc     60

tgcacagcct ctggattctc cttcagtgac gaccactaca tgtgctgggt ccgccaggct    120

ccagggaagg ggctgcagtg gatcgcatgc atgtatgttg gtagtagtgg tgccacttat    180

tacgcgagct gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact    240

ctgcaaatga ccagtctgac agccgcggac acggccacct atttctgtgc gagagatgat    300

tggactagtt attatgcgtg ggggtattgg gccttgtggg gcccgggcac cctcgtcacc    360

gtctcgagcg cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc    420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg    480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta    540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc    600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaga    660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc    720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc    780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag    840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag    900

cagtacgcca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg    960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa   1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc   1080

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc   1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg   1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag   1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac   1320

cactacacgc agaagagcct ctccctgtct ccgggtaaa                          1359


<210>  1012
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1012
cagtcgttgg aggagtccgg gggagacctg gtcaagcctg gaggaaccct gacactcacc     60

tgcacagcct ctggattctc cttcagtgac gaccactaca tgtgctgggt ccgccaggct    120

ccagggaagg ggctgcagtg gatcgcatgc atgtatgttg gtagtagtgg tgccacttat    180

tacgcgagct gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact    240

ctgcaaatga ccagtctgac agccgcggac acggccacct atttctgtgc gagagatgat    300

tggactagtt attatgcgtg ggggtattgg gccttgtggg gcccgggcac cctcgtcacc    360

gtctcgagc                                                            369


<210>  1013
<211>  87
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1013
cagtcgttgg aggagtccgg gggagacctg gtcaagcctg gaggaaccct gacactcacc     60

tgcacagcct ctggattctc cttcagt                                         87


<210>  1014
<211>  18
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1014
gacgaccact acatgtgc                                                   18


<210>  1015
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1015
tgggtccgcc aggctccagg gaaggggctg cagtggatcg ca                        42


<210>  1016
<211>  54
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1016
tgcatgtatg ttggtagtag tggtgccact tattacgcga gctgggcgaa aggc           54


<210>  1017
<211>  93
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1017
cgattcacca tctccaaaac ctcgtcgacc acggtgactc tgcaaatgac cagtctgaca     60

gccgcggaca cggccaccta tttctgtgcg aga                                  93


<210>  1018
<211>  42
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1018
gatgattgga ctagttatta tgcgtggggg tattgggcct tg                        42


<210>  1019
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1019
tggggcccgg gcaccctcgt caccgtctcg agc                                  33


<210>  1020
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1020
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  1021
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1021

Ala Asp Ile Val Met Thr Gln Asn Pro Ala Ser Val Ser Glu Pro Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Val Asn Ser 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ile Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Phe Ser Asn Ser Gly Thr 
                85                  90                  95      


Ile Tyr Gly Ser Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  1022
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1022

Ala Asp Ile Val Met Thr Gln Asn Pro Ala Ser Val Ser Glu Pro Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Val Asn Ser 
            20                  25                  30          


Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu 
        35                  40                  45              


Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ile Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Phe Ser Asn Ser Gly Thr 
                85                  90                  95      


Ile Tyr Gly Ser Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110         


<210>  1023
<211>  24
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1023

Ala Asp Ile Val Met Thr Gln Asn Pro Ala Ser Val Ser Glu Pro Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys 
            20                  


<210>  1024
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1024

Gln Ala Ser Gln Ser Val Asn Ser Trp Leu Ser 
1               5                   10      


<210>  1025
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1025

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Phe Leu Ile Tyr 
1               5                   10                  15  


<210>  1026
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1026

Lys Ala Ser Thr Leu Ala Ser 
1               5           


<210>  1027
<211>  32
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1027

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ile Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1028
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1028

Gln Phe Ser Asn Ser Gly Thr Ile Tyr Gly Ser Gly 
1               5                   10          


<210>  1029
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1029

Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
1               5                   10      


<210>  1030
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1030

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  1031
<211>  654
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1031
gctgacattg tgatgaccca gaatccagcc tccgtgtctg aacctgtggg aggcacagtc     60

accatcaagt gccaggccag tcagagcgtt aatagttggt tatcctggta tcagcagaaa    120

ccagggcagc ctcccaagtt cctgatctac aaggcatcca ctctggcatc tggggtctca    180

tcgcggttca aaggcagtgg gattgggaca gagttcactc tcaccatcag cgacctggag    240

tgtgccgatg ctgccacgta ctattgccaa tttagtaata gtggtactat ttatgggagt    300

ggtttcggcg gagggaccga ggtggtggtc aaacgtacgg tagcggcccc atctgtcttc    360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg    420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg    480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc    540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc    600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt          654


<210>  1032
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1032
gctgacattg tgatgaccca gaatccagcc tccgtgtctg aacctgtggg aggcacagtc     60

accatcaagt gccaggccag tcagagcgtt aatagttggt tatcctggta tcagcagaaa    120

ccagggcagc ctcccaagtt cctgatctac aaggcatcca ctctggcatc tggggtctca    180

tcgcggttca aaggcagtgg gattgggaca gagttcactc tcaccatcag cgacctggag    240

tgtgccgatg ctgccacgta ctattgccaa tttagtaata gtggtactat ttatgggagt    300

ggtttcggcg gagggaccga ggtggtggtc aaacgt                              336


<210>  1033
<211>  72
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1033
gctgacattg tgatgaccca gaatccagcc tccgtgtctg aacctgtggg aggcacagtc     60

accatcaagt gc                                                         72


<210>  1034
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1034
caggccagtc agagcgttaa tagttggtta tcc                                  33


<210>  1035
<211>  45
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1035
tggtatcagc agaaaccagg gcagcctccc aagttcctga tctac                     45


<210>  1036
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1036
aaggcatcca ctctggcatc t                                               21


<210>  1037
<211>  96
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1037
ggggtctcat cgcggttcaa aggcagtggg attgggacag agttcactct caccatcagc     60

gacctggagt gtgccgatgc tgccacgtac tattgc                               96


<210>  1038
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1038
caatttagta atagtggtac tatttatggg agtggt                               36


<210>  1039
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1039
ttcggcggag ggaccgaggt ggtggtcaaa cgt                                  33


<210>  1040
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1040
acggtagcgg ccccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  1041
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1041

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Ser Ala Gln 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Ala Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  1042
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1042

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Ser Ala Gln 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  1043
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1043

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  1044
<211>  5
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1044

Ser Asn Ala Ile Ser 
1               5   


<210>  1045
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1045

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  1046
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1046

Val Ile Tyr Val Ile Gly Val Thr Asp Tyr Ala Ser Ser Ala Gln Gly 
1               5                   10                  15      


<210>  1047
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1047

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1048
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1048

Val Tyr Asp Ser Gly Trp Asn His Phe Asn Leu 
1               5                   10      


<210>  1049
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1049

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  1050
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1050

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  1051
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1051
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt agcaatgcaa taagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg ggtcggagtc atttatgtta ttggtgtcac tgactacgcg    180

agctctgcgc aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agtttatgat    300

tctggctgga atcactttaa cttgtggggc caagggaccc tcgtcaccgt ctcgagcgcc    360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg    480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga    540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac    600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acgcgagagt tgagcccaaa    660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg    720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac    840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc    900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag    960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa   1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc   1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg   1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1320

aagagcctct ccctgtctcc gggtaaa                                       1347


<210>  1052
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1052
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt agcaatgcaa taagctgggt ccgtcaggct    120

ccagggaagg ggctggagtg ggtcggagtc atttatgtta ttggtgtcac tgactacgcg    180

agctctgcgc aaggccgatt caccatctcc agagacaatt ccaagaacac cctgtatctt    240

caaatgaaca gcctgagagc tgaggacact gctgtgtatt actgtgctag agtttatgat    300

tctggctgga atcactttaa cttgtggggc caagggaccc tcgtcaccgt ctcgagc       357


<210>  1053
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1053
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccgtcagt                                      90


<210>  1054
<211>  15
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1054
agcaatgcaa taagc                                                      15


<210>  1055
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1055
tgggtccgtc aggctccagg gaaggggctg gagtgggtcg ga                        42


<210>  1056
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1056
gtcatttatg ttattggtgt cactgactac gcgagctctg cgcaaggc                  48


<210>  1057
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1057
cgattcacca tctccagaga caattccaag aacaccctgt atcttcaaat gaacagcctg     60

agagctgagg acactgctgt gtattactgt gctaga                               96


<210>  1058
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1058
gtttatgatt ctggctggaa tcactttaac ttg                                  33


<210>  1059
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1059
tggggccaag ggaccctcgt caccgtctcg agc                                  33


<210>  1060
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1060
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacgcgag agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc    540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag    720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa                                     990


<210>  1061
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1061

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ala Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  1062
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1062

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Val Ala Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210>  1063
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1063

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  1064
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1064

Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  1065
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1065

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1066
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1066

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  1067
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1067

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1068
<211>  12
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1068

Gln Gln Ala Tyr Ser Val Ala Asn Val Asp Asn Ala 
1               5                   10          


<210>  1069
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1069

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  1070
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1070

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  1071
<211>  651
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1071
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca    120

ggaaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg agtcccatca    180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct    240

gatgattttg caacttatta ctgccaacag gcttatagtg ttgccaatgt tgataatgct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgtacggtgg ctgcaccatc tgtcttcatc    360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             651


<210>  1072
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1072
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca    120

ggaaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg agtcccatca    180

aggttcagcg gcagtggatc tggaacagaa ttcactctca ccatcagcag cctgcagcct    240

gatgattttg caacttatta ctgccaacag gcttatagtg ttgccaatgt tgataatgct    300

ttcggcggag gaaccaaggt ggaaatcaaa cgt                                 333


<210>  1073
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1073
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgc                                                             69


<210>  1074
<211>  33
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1074
caggccagtc agagcattag cagttggtta gcc                                  33


<210>  1075
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1075
tggtatcagc agaaaccagg aaaagcccct aagctcctga tctat                     45


<210>  1076
<211>  21
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1076
gaagcatcca aactggcatc t                                               21


<210>  1077
<211>  96
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1077
ggagtcccat caaggttcag cggcagtgga tctggaacag aattcactct caccatcagc     60

agcctgcagc ctgatgattt tgcaacttat tactgc                               96


<210>  1078
<211>  36
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  1078
caacaggctt atagtgttgc caatgttgat aatgct                               36


<210>  1079
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1079
ttcggcggag gaaccaaggt ggaaatcaaa cgt                                  33


<210>  1080
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized antibody sequence

<400>  1080
acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga     60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    300

ttcaacaggg gagagtgt                                                  318


<210>  1081
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  1081

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                 135                 140                 


Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                 150                 155                 160 


Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                 170                 175     


Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                 185                 190         


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                 200                 205             


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                 215                 220                 


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                 230                 235                 240 


His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                 250                 255     


Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                 265                 270         


Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                 280                 285             


Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                 295                 300                 


Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                 310                 315                 320 


Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                 330                 335     


His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                 345                 350         


Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                 360                 365             


Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                 375                 380                 


Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                 390                 395                 400 


Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                 410                 415     


Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                 425                 430         


Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                 440                 445             


Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                 455                 460                 


Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                 470                 475                 480 


Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                 490                 495     


Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                 505                 510         


Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                 520                 525             


Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                 535                 540                 


Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                 550                 555                 560 


Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                 570                 575     


Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                 585                 590         


Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                 600                 605             


Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                 615                 620                 


Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                 630                 635                 640 


Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                 650                 655     


Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                 665                 670         


Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                 680                 685             


Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                 695                 700                 


Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                 710                 715                 720 


Leu Thr Tyr Lys Val Pro Gln Ser 
                725             

