                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Liao, James C.
       Bogorad, Igor
 
<120>  NON-OXIDATIVE METABOLIC PATHWAY FOR CHEMICAL PRODUCTION

<130>  00011-071WO1

<140>  Not yet assigned
<141>  2014-03-14

<150>  US 61/785,254
<151>  2013-03-14

<150>  US 61/785,143
<151>  2013-03-14

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  2478
<212>  DNA
<213>  Bifidobacterium adolescentis


<220>
<221>  CDS
<222>  (1)..(2478)

<400>  1
atg acg agt cct gtt att ggc acc cct tgg aag aag ctg aac gct ccg         48
Met Thr Ser Pro Val Ile Gly Thr Pro Trp Lys Lys Leu Asn Ala Pro           
1               5                   10                  15                

gtt tcc gag gaa gct atc gaa ggc gtg gat aag tac tgg cgc gca gcc         96
Val Ser Glu Glu Ala Ile Glu Gly Val Asp Lys Tyr Trp Arg Ala Ala           
            20                  25                  30                    

aac tac ctc tcc atc ggc cag atc tat ctg cgt agc aac ccg ctg atg        144
Asn Tyr Leu Ser Ile Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu Met           
        35                  40                  45                        

aag gag cct ttc acc cgc gaa gac gtc aag cac cgt ctg gtc ggt cac        192
Lys Glu Pro Phe Thr Arg Glu Asp Val Lys His Arg Leu Val Gly His           
    50                  55                  60                            

tgg ggc acc acc ccg ggc ctg aac ttc ctc atc ggc cac atc aac cgt        240
Trp Gly Thr Thr Pro Gly Leu Asn Phe Leu Ile Gly His Ile Asn Arg           
65                  70                  75                  80            

ctc att gct gat cac cag cag aac act gtg atc atc atg ggc ccg ggc        288
Leu Ile Ala Asp His Gln Gln Asn Thr Val Ile Ile Met Gly Pro Gly           
                85                  90                  95                

cac ggc ggc ccg gct ggt acc gct cag tcc tac ctg gac ggc acc tac        336
His Gly Gly Pro Ala Gly Thr Ala Gln Ser Tyr Leu Asp Gly Thr Tyr           
            100                 105                 110                   

acc gag tac ttc ccg aac atc acc aag gat gag gct ggc ctg cag aag        384
Thr Glu Tyr Phe Pro Asn Ile Thr Lys Asp Glu Ala Gly Leu Gln Lys           
        115                 120                 125                       

ttc ttc cgc cag ttc tcc tac ccg ggt ggc atc ccg tcc cac tac gct        432
Phe Phe Arg Gln Phe Ser Tyr Pro Gly Gly Ile Pro Ser His Tyr Ala           
    130                 135                 140                           

ccg gag acc ccg ggc tcc atc cac gaa ggc ggc gag ctg ggt tac gcc        480
Pro Glu Thr Pro Gly Ser Ile His Glu Gly Gly Glu Leu Gly Tyr Ala           
145                 150                 155                 160           

ctg tcc cac gcc tac ggc gct gtg atg aac aac ccg agc ctg ttc gtc        528
Leu Ser His Ala Tyr Gly Ala Val Met Asn Asn Pro Ser Leu Phe Val           
                165                 170                 175               

ccg gcc atc gtc ggc gac ggt gaa gct gag acc ggc ccg ctg gcc acc        576
Pro Ala Ile Val Gly Asp Gly Glu Ala Glu Thr Gly Pro Leu Ala Thr           
            180                 185                 190                   

ggc tgg cag tcc aac aag ctc atc aac ccg cgc acc gac ggt atc gtg        624
Gly Trp Gln Ser Asn Lys Leu Ile Asn Pro Arg Thr Asp Gly Ile Val           
        195                 200                 205                       

ctg ccg atc ctg cac ctc aac ggc tac aag atc gcc aac ccg acc atc        672
Leu Pro Ile Leu His Leu Asn Gly Tyr Lys Ile Ala Asn Pro Thr Ile           
    210                 215                 220                           

ctg tcc cgc atc tcc gac gaa gag ctc cac gag ttc ttc cac ggc atg        720
Leu Ser Arg Ile Ser Asp Glu Glu Leu His Glu Phe Phe His Gly Met           
225                 230                 235                 240           

ggc tat gag ccg tac gag ttc gtc gct ggc ttc gac aac gag gat cac        768
Gly Tyr Glu Pro Tyr Glu Phe Val Ala Gly Phe Asp Asn Glu Asp His           
                245                 250                 255               

ctg tcg atc cac cgt cgt ttc gcc gag ctg ttc gag acc gtc ttc gac        816
Leu Ser Ile His Arg Arg Phe Ala Glu Leu Phe Glu Thr Val Phe Asp           
            260                 265                 270                   

gag atc tgc gac atc aag gcc gcc gct cag acc gac gac atg act cgt        864
Glu Ile Cys Asp Ile Lys Ala Ala Ala Gln Thr Asp Asp Met Thr Arg           
        275                 280                 285                       

ccg ttc tac ccg atg atc atc ttc cgt acc ccg aag ggc tgg acc tgc        912
Pro Phe Tyr Pro Met Ile Ile Phe Arg Thr Pro Lys Gly Trp Thr Cys           
    290                 295                 300                           

ccg aag ttc atc gac ggc aag aag acc gag ggc tcc tgg cgt tcc cac        960
Pro Lys Phe Ile Asp Gly Lys Lys Thr Glu Gly Ser Trp Arg Ser His           
305                 310                 315                 320           

cag gtg ccg ctg gct tcc gcc cgc gat acc gag gcc cac ttc gag gtc       1008
Gln Val Pro Leu Ala Ser Ala Arg Asp Thr Glu Ala His Phe Glu Val           
                325                 330                 335               

ctc aag aac tgg ctc gag tcc tac aag ccg gaa gag ctg ttc gac gag       1056
Leu Lys Asn Trp Leu Glu Ser Tyr Lys Pro Glu Glu Leu Phe Asp Glu           
            340                 345                 350                   

aac ggc gcc gtg aag ccg gaa gtc acc gcc ttc atg ccg acc ggc gaa       1104
Asn Gly Ala Val Lys Pro Glu Val Thr Ala Phe Met Pro Thr Gly Glu           
        355                 360                 365                       

ctg cgc atc ggt gag aac ccg aac gcc aac ggt ggc cgc atc cgc gaa       1152
Leu Arg Ile Gly Glu Asn Pro Asn Ala Asn Gly Gly Arg Ile Arg Glu           
    370                 375                 380                           

gag ctg aag ctg ccg aag ctg gaa gac tac gag gtc aag gaa gtc gcc       1200
Glu Leu Lys Leu Pro Lys Leu Glu Asp Tyr Glu Val Lys Glu Val Ala           
385                 390                 395                 400           

gag tac ggc cac ggc tgg ggc cag ctc gag gcc acc cgt cgt ctg ggc       1248
Glu Tyr Gly His Gly Trp Gly Gln Leu Glu Ala Thr Arg Arg Leu Gly           
                405                 410                 415               

gtc tac acc cgc gac atc atc aag aac aac ccg gac tcc ttc cgt atc       1296
Val Tyr Thr Arg Asp Ile Ile Lys Asn Asn Pro Asp Ser Phe Arg Ile           
            420                 425                 430                   

ttc gga ccg gat gag acc gct tcc aac cgt ctg cag gcc gct tac gac       1344
Phe Gly Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr Asp           
        435                 440                 445                       

gtc acc aac aag cag tgg gac gcc ggc tac ctg tcc gct cag gtc gac       1392
Val Thr Asn Lys Gln Trp Asp Ala Gly Tyr Leu Ser Ala Gln Val Asp           
    450                 455                 460                           

gag cac atg gct gtc acc ggc cag gtc acc gag cag ctt tcc gag cac       1440
Glu His Met Ala Val Thr Gly Gln Val Thr Glu Gln Leu Ser Glu His           
465                 470                 475                 480           

cag atg gaa ggc ttc ctc gag ggc tac ctg ctg acc ggc cgt cac ggc       1488
Gln Met Glu Gly Phe Leu Glu Gly Tyr Leu Leu Thr Gly Arg His Gly           
                485                 490                 495               

atc tgg agc tcc tat gag tcc ttc gtg cac gtg atc gac tcc atg ctg       1536
Ile Trp Ser Ser Tyr Glu Ser Phe Val His Val Ile Asp Ser Met Leu           
            500                 505                 510                   

aac cag cac gcc aag tgg ctc gag gct acc gtc cgc gag att ccg tgg       1584
Asn Gln His Ala Lys Trp Leu Glu Ala Thr Val Arg Glu Ile Pro Trp           
        515                 520                 525                       

cgc aag ccg atc tcc tcc atg aac ctg ctc gtc tcc tcc cac gtg tgg       1632
Arg Lys Pro Ile Ser Ser Met Asn Leu Leu Val Ser Ser His Val Trp           
    530                 535                 540                           

cgt cag gat cac aac ggc ttc tcc cac cag gat ccg ggt gtc acc tcc       1680
Arg Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Val Thr Ser           
545                 550                 555                 560           

gtc ctg ctg aac aag tgc ttc aac aac gat cac gtg atc ggc atc tac       1728
Val Leu Leu Asn Lys Cys Phe Asn Asn Asp His Val Ile Gly Ile Tyr           
                565                 570                 575               

ttc ccg gtg gat tcc aac atg ctg ctc gct gtg gct gag aag tgc tac       1776
Phe Pro Val Asp Ser Asn Met Leu Leu Ala Val Ala Glu Lys Cys Tyr           
            580                 585                 590                   

aag tcc acc aac aag atc aac gcc atc atc gcc ggc aag cag ccg gcc       1824
Lys Ser Thr Asn Lys Ile Asn Ala Ile Ile Ala Gly Lys Gln Pro Ala           
        595                 600                 605                       

gcc acc tgg ctg acc ctg gac gaa gct cgc gcc gag ctc gag aag ggt       1872
Ala Thr Trp Leu Thr Leu Asp Glu Ala Arg Ala Glu Leu Glu Lys Gly           
    610                 615                 620                           

gct gcc gag tgg aag tgg gct tcc aac gtg aag tcc aac gat gag gct       1920
Ala Ala Glu Trp Lys Trp Ala Ser Asn Val Lys Ser Asn Asp Glu Ala           
625                 630                 635                 640           

cag atc gtg ctc gcc gcc acc ggt gat gtt ccg act cag gaa atc atg       1968
Gln Ile Val Leu Ala Ala Thr Gly Asp Val Pro Thr Gln Glu Ile Met           
                645                 650                 655               

gcc gct gcc gac aag ctg gac gcc atg ggc atc aag ttc aag gtc gtc       2016
Ala Ala Ala Asp Lys Leu Asp Ala Met Gly Ile Lys Phe Lys Val Val           
            660                 665                 670                   

aac gtg gtt gac ctg gtc aag ctg cag tcc gcc aag gag aac aac gag       2064
Asn Val Val Asp Leu Val Lys Leu Gln Ser Ala Lys Glu Asn Asn Glu           
        675                 680                 685                       

gcc ctc tcc gat gag gag ttc gct gag ctg ttc acc gag gac aag ccg       2112
Ala Leu Ser Asp Glu Glu Phe Ala Glu Leu Phe Thr Glu Asp Lys Pro           
    690                 695                 700                           

gtc ctg ttc gct tac cac tcc tat gcc cgc gat gtg cgt ggt ctg atc       2160
Val Leu Phe Ala Tyr His Ser Tyr Ala Arg Asp Val Arg Gly Leu Ile           
705                 710                 715                 720           

tac gat cgc ccg aac cac gac aac ttc aac gtt cac ggc tac gag gag       2208
Tyr Asp Arg Pro Asn His Asp Asn Phe Asn Val His Gly Tyr Glu Glu           
                725                 730                 735               

cag ggc tcc acc acc acc ccg tac gac atg gtt cgc gtg aac aac atc       2256
Gln Gly Ser Thr Thr Thr Pro Tyr Asp Met Val Arg Val Asn Asn Ile           
            740                 745                 750                   

gat cgc tac gag ctc cag gct gaa gct ctg cgc atg att gac gct gac       2304
Asp Arg Tyr Glu Leu Gln Ala Glu Ala Leu Arg Met Ile Asp Ala Asp           
        755                 760                 765                       

aag tac gcc gac aag atc aac gag ctc gag gcc ttc cgt cag gaa gcc       2352
Lys Tyr Ala Asp Lys Ile Asn Glu Leu Glu Ala Phe Arg Gln Glu Ala           
    770                 775                 780                           

ttc cag ttc gct gtc gac aac ggc tac gat cac ccg gat tac acc gac       2400
Phe Gln Phe Ala Val Asp Asn Gly Tyr Asp His Pro Asp Tyr Thr Asp           
785                 790                 795                 800           

tgg gtc tac tcc ggt gtc aac acc aac aag cag ggt gct atc tcc gct       2448
Trp Val Tyr Ser Gly Val Asn Thr Asn Lys Gln Gly Ala Ile Ser Ala           
                805                 810                 815               

acc gcc gca acc gct ggc gat aac gag tga                               2478
Thr Ala Ala Thr Ala Gly Asp Asn Glu                                       
            820                 825                                       


<210>  2
<211>  825
<212>  PRT
<213>  Bifidobacterium adolescentis

<400>  2

Met Thr Ser Pro Val Ile Gly Thr Pro Trp Lys Lys Leu Asn Ala Pro 
1               5                   10                  15      


Val Ser Glu Glu Ala Ile Glu Gly Val Asp Lys Tyr Trp Arg Ala Ala 
            20                  25                  30          


Asn Tyr Leu Ser Ile Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu Met 
        35                  40                  45              


Lys Glu Pro Phe Thr Arg Glu Asp Val Lys His Arg Leu Val Gly His 
    50                  55                  60                  


Trp Gly Thr Thr Pro Gly Leu Asn Phe Leu Ile Gly His Ile Asn Arg 
65                  70                  75                  80  


Leu Ile Ala Asp His Gln Gln Asn Thr Val Ile Ile Met Gly Pro Gly 
                85                  90                  95      


His Gly Gly Pro Ala Gly Thr Ala Gln Ser Tyr Leu Asp Gly Thr Tyr 
            100                 105                 110         


Thr Glu Tyr Phe Pro Asn Ile Thr Lys Asp Glu Ala Gly Leu Gln Lys 
        115                 120                 125             


Phe Phe Arg Gln Phe Ser Tyr Pro Gly Gly Ile Pro Ser His Tyr Ala 
    130                 135                 140                 


Pro Glu Thr Pro Gly Ser Ile His Glu Gly Gly Glu Leu Gly Tyr Ala 
145                 150                 155                 160 


Leu Ser His Ala Tyr Gly Ala Val Met Asn Asn Pro Ser Leu Phe Val 
                165                 170                 175     


Pro Ala Ile Val Gly Asp Gly Glu Ala Glu Thr Gly Pro Leu Ala Thr 
            180                 185                 190         


Gly Trp Gln Ser Asn Lys Leu Ile Asn Pro Arg Thr Asp Gly Ile Val 
        195                 200                 205             


Leu Pro Ile Leu His Leu Asn Gly Tyr Lys Ile Ala Asn Pro Thr Ile 
    210                 215                 220                 


Leu Ser Arg Ile Ser Asp Glu Glu Leu His Glu Phe Phe His Gly Met 
225                 230                 235                 240 


Gly Tyr Glu Pro Tyr Glu Phe Val Ala Gly Phe Asp Asn Glu Asp His 
                245                 250                 255     


Leu Ser Ile His Arg Arg Phe Ala Glu Leu Phe Glu Thr Val Phe Asp 
            260                 265                 270         


Glu Ile Cys Asp Ile Lys Ala Ala Ala Gln Thr Asp Asp Met Thr Arg 
        275                 280                 285             


Pro Phe Tyr Pro Met Ile Ile Phe Arg Thr Pro Lys Gly Trp Thr Cys 
    290                 295                 300                 


Pro Lys Phe Ile Asp Gly Lys Lys Thr Glu Gly Ser Trp Arg Ser His 
305                 310                 315                 320 


Gln Val Pro Leu Ala Ser Ala Arg Asp Thr Glu Ala His Phe Glu Val 
                325                 330                 335     


Leu Lys Asn Trp Leu Glu Ser Tyr Lys Pro Glu Glu Leu Phe Asp Glu 
            340                 345                 350         


Asn Gly Ala Val Lys Pro Glu Val Thr Ala Phe Met Pro Thr Gly Glu 
        355                 360                 365             


Leu Arg Ile Gly Glu Asn Pro Asn Ala Asn Gly Gly Arg Ile Arg Glu 
    370                 375                 380                 


Glu Leu Lys Leu Pro Lys Leu Glu Asp Tyr Glu Val Lys Glu Val Ala 
385                 390                 395                 400 


Glu Tyr Gly His Gly Trp Gly Gln Leu Glu Ala Thr Arg Arg Leu Gly 
                405                 410                 415     


Val Tyr Thr Arg Asp Ile Ile Lys Asn Asn Pro Asp Ser Phe Arg Ile 
            420                 425                 430         


Phe Gly Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr Asp 
        435                 440                 445             


Val Thr Asn Lys Gln Trp Asp Ala Gly Tyr Leu Ser Ala Gln Val Asp 
    450                 455                 460                 


Glu His Met Ala Val Thr Gly Gln Val Thr Glu Gln Leu Ser Glu His 
465                 470                 475                 480 


Gln Met Glu Gly Phe Leu Glu Gly Tyr Leu Leu Thr Gly Arg His Gly 
                485                 490                 495     


Ile Trp Ser Ser Tyr Glu Ser Phe Val His Val Ile Asp Ser Met Leu 
            500                 505                 510         


Asn Gln His Ala Lys Trp Leu Glu Ala Thr Val Arg Glu Ile Pro Trp 
        515                 520                 525             


Arg Lys Pro Ile Ser Ser Met Asn Leu Leu Val Ser Ser His Val Trp 
    530                 535                 540                 


Arg Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Val Thr Ser 
545                 550                 555                 560 


Val Leu Leu Asn Lys Cys Phe Asn Asn Asp His Val Ile Gly Ile Tyr 
                565                 570                 575     


Phe Pro Val Asp Ser Asn Met Leu Leu Ala Val Ala Glu Lys Cys Tyr 
            580                 585                 590         


Lys Ser Thr Asn Lys Ile Asn Ala Ile Ile Ala Gly Lys Gln Pro Ala 
        595                 600                 605             


Ala Thr Trp Leu Thr Leu Asp Glu Ala Arg Ala Glu Leu Glu Lys Gly 
    610                 615                 620                 


Ala Ala Glu Trp Lys Trp Ala Ser Asn Val Lys Ser Asn Asp Glu Ala 
625                 630                 635                 640 


Gln Ile Val Leu Ala Ala Thr Gly Asp Val Pro Thr Gln Glu Ile Met 
                645                 650                 655     


Ala Ala Ala Asp Lys Leu Asp Ala Met Gly Ile Lys Phe Lys Val Val 
            660                 665                 670         


Asn Val Val Asp Leu Val Lys Leu Gln Ser Ala Lys Glu Asn Asn Glu 
        675                 680                 685             


Ala Leu Ser Asp Glu Glu Phe Ala Glu Leu Phe Thr Glu Asp Lys Pro 
    690                 695                 700                 


Val Leu Phe Ala Tyr His Ser Tyr Ala Arg Asp Val Arg Gly Leu Ile 
705                 710                 715                 720 


Tyr Asp Arg Pro Asn His Asp Asn Phe Asn Val His Gly Tyr Glu Glu 
                725                 730                 735     


Gln Gly Ser Thr Thr Thr Pro Tyr Asp Met Val Arg Val Asn Asn Ile 
            740                 745                 750         


Asp Arg Tyr Glu Leu Gln Ala Glu Ala Leu Arg Met Ile Asp Ala Asp 
        755                 760                 765             


Lys Tyr Ala Asp Lys Ile Asn Glu Leu Glu Ala Phe Arg Gln Glu Ala 
    770                 775                 780                 


Phe Gln Phe Ala Val Asp Asn Gly Tyr Asp His Pro Asp Tyr Thr Asp 
785                 790                 795                 800 


Trp Val Tyr Ser Gly Val Asn Thr Asn Lys Gln Gly Ala Ile Ser Ala 
                805                 810                 815     


Thr Ala Ala Thr Ala Gly Asp Asn Glu 
            820                 825 


<210>  3
<211>  999
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(999)

<400>  3
atg aaa acg tta ggt gaa ttt att gtc gaa aag cag cac gag ttt tct         48
Met Lys Thr Leu Gly Glu Phe Ile Val Glu Lys Gln His Glu Phe Ser           
1               5                   10                  15                

cat gct acc ggt gag ctc act gct ttg ctg tcg gca ata aaa ctg ggc         96
His Ala Thr Gly Glu Leu Thr Ala Leu Leu Ser Ala Ile Lys Leu Gly           
            20                  25                  30                    

gcc aag att atc cat cgc gat atc aac aaa gca gga ctg gtt gat atc        144
Ala Lys Ile Ile His Arg Asp Ile Asn Lys Ala Gly Leu Val Asp Ile           
        35                  40                  45                        

ctg ggt gcc agc ggt gct gag aac gtg cag ggc gag gtt cag cag aaa        192
Leu Gly Ala Ser Gly Ala Glu Asn Val Gln Gly Glu Val Gln Gln Lys           
    50                  55                  60                            

ctc gac ttg ttc gct aat gaa aaa ctg aaa gcc gca ctg aaa gca cgc        240
Leu Asp Leu Phe Ala Asn Glu Lys Leu Lys Ala Ala Leu Lys Ala Arg           
65                  70                  75                  80            

gat atc gtt gcg ggc att gcc tct gaa gaa gaa gat gag att gtc gtc        288
Asp Ile Val Ala Gly Ile Ala Ser Glu Glu Glu Asp Glu Ile Val Val           
                85                  90                  95                

ttt gaa ggc tgt gaa cac gca aaa tac gtg gtg ctg atg gac ccc ctg        336
Phe Glu Gly Cys Glu His Ala Lys Tyr Val Val Leu Met Asp Pro Leu           
            100                 105                 110                   

gat ggc tcg tcc aac atc gat gtt aac gtc tct gtc ggt acc att ttc        384
Asp Gly Ser Ser Asn Ile Asp Val Asn Val Ser Val Gly Thr Ile Phe           
        115                 120                 125                       

tcc atc tac cgc cgc gtt acg cct gtt ggc acg ccg gta acg gaa gaa        432
Ser Ile Tyr Arg Arg Val Thr Pro Val Gly Thr Pro Val Thr Glu Glu           
    130                 135                 140                           

gat ttc ctc cag cct ggt aac aaa cag gtt gcg gca ggt tac gtg gta        480
Asp Phe Leu Gln Pro Gly Asn Lys Gln Val Ala Ala Gly Tyr Val Val           
145                 150                 155                 160           

tac ggc tcc tct acc atg ctg gtt tac acc acc gga tgc ggt gtt cac        528
Tyr Gly Ser Ser Thr Met Leu Val Tyr Thr Thr Gly Cys Gly Val His           
                165                 170                 175               

gcc ttt act tac gat cct tcg ctc ggc gtt ttc tgc ctg tgc cag gaa        576
Ala Phe Thr Tyr Asp Pro Ser Leu Gly Val Phe Cys Leu Cys Gln Glu           
            180                 185                 190                   

cgg atg cgc ttc ccg gag aaa ggc aaa acc tac tcc atc aac gaa gga        624
Arg Met Arg Phe Pro Glu Lys Gly Lys Thr Tyr Ser Ile Asn Glu Gly           
        195                 200                 205                       

aac tac att aag ttt ccg aac ggg gtg aag aag tac att aaa ttc tgc        672
Asn Tyr Ile Lys Phe Pro Asn Gly Val Lys Lys Tyr Ile Lys Phe Cys           
    210                 215                 220                           

cag gaa gaa gat aaa tcc acc aac cgc cct tat acc tca cgt tat atc        720
Gln Glu Glu Asp Lys Ser Thr Asn Arg Pro Tyr Thr Ser Arg Tyr Ile           
225                 230                 235                 240           

ggt tca ctg gtc gcg gat ttc cac cgt aac ctg ctg aaa ggc ggt att        768
Gly Ser Leu Val Ala Asp Phe His Arg Asn Leu Leu Lys Gly Gly Ile           
                245                 250                 255               

tat ctc tac cca agc acc gcc agc cac ccg gac ggc aaa ctg cgt ttg        816
Tyr Leu Tyr Pro Ser Thr Ala Ser His Pro Asp Gly Lys Leu Arg Leu           
            260                 265                 270                   

ctg tat gag tgc aac ccg atg gca ttc ctg gcg gaa caa gcg ggc ggt        864
Leu Tyr Glu Cys Asn Pro Met Ala Phe Leu Ala Glu Gln Ala Gly Gly           
        275                 280                 285                       

aaa gcg agc gat ggc aaa gag cgt att ctg gat atc atc ccg gaa acc        912
Lys Ala Ser Asp Gly Lys Glu Arg Ile Leu Asp Ile Ile Pro Glu Thr           
    290                 295                 300                           

ctg cac cag cgc cgt tca ttc ttt gtc ggc aac gac cat atg gtt gaa        960
Leu His Gln Arg Arg Ser Phe Phe Val Gly Asn Asp His Met Val Glu           
305                 310                 315                 320           

gat gtc gaa cgc ttt atc cgt gag ttc ccg gac gcg taa                    999
Asp Val Glu Arg Phe Ile Arg Glu Phe Pro Asp Ala                           
                325                 330                                   


<210>  4
<211>  332
<212>  PRT
<213>  Escherichia coli

<400>  4

Met Lys Thr Leu Gly Glu Phe Ile Val Glu Lys Gln His Glu Phe Ser 
1               5                   10                  15      


His Ala Thr Gly Glu Leu Thr Ala Leu Leu Ser Ala Ile Lys Leu Gly 
            20                  25                  30          


Ala Lys Ile Ile His Arg Asp Ile Asn Lys Ala Gly Leu Val Asp Ile 
        35                  40                  45              


Leu Gly Ala Ser Gly Ala Glu Asn Val Gln Gly Glu Val Gln Gln Lys 
    50                  55                  60                  


Leu Asp Leu Phe Ala Asn Glu Lys Leu Lys Ala Ala Leu Lys Ala Arg 
65                  70                  75                  80  


Asp Ile Val Ala Gly Ile Ala Ser Glu Glu Glu Asp Glu Ile Val Val 
                85                  90                  95      


Phe Glu Gly Cys Glu His Ala Lys Tyr Val Val Leu Met Asp Pro Leu 
            100                 105                 110         


Asp Gly Ser Ser Asn Ile Asp Val Asn Val Ser Val Gly Thr Ile Phe 
        115                 120                 125             


Ser Ile Tyr Arg Arg Val Thr Pro Val Gly Thr Pro Val Thr Glu Glu 
    130                 135                 140                 


Asp Phe Leu Gln Pro Gly Asn Lys Gln Val Ala Ala Gly Tyr Val Val 
145                 150                 155                 160 


Tyr Gly Ser Ser Thr Met Leu Val Tyr Thr Thr Gly Cys Gly Val His 
                165                 170                 175     


Ala Phe Thr Tyr Asp Pro Ser Leu Gly Val Phe Cys Leu Cys Gln Glu 
            180                 185                 190         


Arg Met Arg Phe Pro Glu Lys Gly Lys Thr Tyr Ser Ile Asn Glu Gly 
        195                 200                 205             


Asn Tyr Ile Lys Phe Pro Asn Gly Val Lys Lys Tyr Ile Lys Phe Cys 
    210                 215                 220                 


Gln Glu Glu Asp Lys Ser Thr Asn Arg Pro Tyr Thr Ser Arg Tyr Ile 
225                 230                 235                 240 


Gly Ser Leu Val Ala Asp Phe His Arg Asn Leu Leu Lys Gly Gly Ile 
                245                 250                 255     


Tyr Leu Tyr Pro Ser Thr Ala Ser His Pro Asp Gly Lys Leu Arg Leu 
            260                 265                 270         


Leu Tyr Glu Cys Asn Pro Met Ala Phe Leu Ala Glu Gln Ala Gly Gly 
        275                 280                 285             


Lys Ala Ser Asp Gly Lys Glu Arg Ile Leu Asp Ile Ile Pro Glu Thr 
    290                 295                 300                 


Leu His Gln Arg Arg Ser Phe Phe Val Gly Asn Asp His Met Val Glu 
305                 310                 315                 320 


Asp Val Glu Arg Phe Ile Arg Glu Phe Pro Asp Ala 
                325                 330         


<210>  5
<211>  678
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(678)

<400>  5
atg aaa cag tat ttg att gcc ccc tca att ctg tcg gct gat ttt gcc         48
Met Lys Gln Tyr Leu Ile Ala Pro Ser Ile Leu Ser Ala Asp Phe Ala           
1               5                   10                  15                

cgc ctg ggt gaa gat acc gca aaa gcc ctg gca gct ggc gct gat gtc         96
Arg Leu Gly Glu Asp Thr Ala Lys Ala Leu Ala Ala Gly Ala Asp Val           
            20                  25                  30                    

gtg cat ttt gac gtc atg gat aac cac tat gtt ccc aat ctg acg att        144
Val His Phe Asp Val Met Asp Asn His Tyr Val Pro Asn Leu Thr Ile           
        35                  40                  45                        

ggg cca atg gtg ctg aaa tcc ttg cgt aac tat ggc att acc gcc cct        192
Gly Pro Met Val Leu Lys Ser Leu Arg Asn Tyr Gly Ile Thr Ala Pro           
    50                  55                  60                            

atc gac gta cac ctg atg gtg aaa ccc gtc gat cgc att gtg cct gat        240
Ile Asp Val His Leu Met Val Lys Pro Val Asp Arg Ile Val Pro Asp           
65                  70                  75                  80            

ttc gct gcc gct ggt gcc agc atc att acc ttt cat cca gaa gcc tcc        288
Phe Ala Ala Ala Gly Ala Ser Ile Ile Thr Phe His Pro Glu Ala Ser           
                85                  90                  95                

gag cat gtt gac cgc acg ctg caa ctg att aaa gaa aat ggc tgt aaa        336
Glu His Val Asp Arg Thr Leu Gln Leu Ile Lys Glu Asn Gly Cys Lys           
            100                 105                 110                   

gcg ggt ctg gta ttt aac ccg gcg aca cct ctg agc tat ctg gat tac        384
Ala Gly Leu Val Phe Asn Pro Ala Thr Pro Leu Ser Tyr Leu Asp Tyr           
        115                 120                 125                       

gtg atg gat aag ctg gat gtg atc ctg ctg atg tcc gtc aac cct ggt        432
Val Met Asp Lys Leu Asp Val Ile Leu Leu Met Ser Val Asn Pro Gly           
    130                 135                 140                           

ttc ggc ggt cag tct ttc att cct caa aca ctg gat aaa ctg cgc gaa        480
Phe Gly Gly Gln Ser Phe Ile Pro Gln Thr Leu Asp Lys Leu Arg Glu           
145                 150                 155                 160           

gta cgt cgc cgt atc gac gag tct ggc ttt gac att cga cta gaa gtg        528
Val Arg Arg Arg Ile Asp Glu Ser Gly Phe Asp Ile Arg Leu Glu Val           
                165                 170                 175               

gac ggt ggc gtg aag gtg aac aac att ggc gaa atc gct gcg gcg ggc        576
Asp Gly Gly Val Lys Val Asn Asn Ile Gly Glu Ile Ala Ala Ala Gly           
            180                 185                 190                   

gcg gat atg ttc gtc gcc ggt tcg gca atc ttc gac cag cca gac tac        624
Ala Asp Met Phe Val Ala Gly Ser Ala Ile Phe Asp Gln Pro Asp Tyr           
        195                 200                 205                       

aaa aaa gtc att gat gaa atg cgc agt gaa ctg gca aag gta agt cat        672
Lys Lys Val Ile Asp Glu Met Arg Ser Glu Leu Ala Lys Val Ser His           
    210                 215                 220                           

gaa taa                                                                678
Glu                                                                       
225                                                                       


<210>  6
<211>  225
<212>  PRT
<213>  Escherichia coli

<400>  6

Met Lys Gln Tyr Leu Ile Ala Pro Ser Ile Leu Ser Ala Asp Phe Ala 
1               5                   10                  15      


Arg Leu Gly Glu Asp Thr Ala Lys Ala Leu Ala Ala Gly Ala Asp Val 
            20                  25                  30          


Val His Phe Asp Val Met Asp Asn His Tyr Val Pro Asn Leu Thr Ile 
        35                  40                  45              


Gly Pro Met Val Leu Lys Ser Leu Arg Asn Tyr Gly Ile Thr Ala Pro 
    50                  55                  60                  


Ile Asp Val His Leu Met Val Lys Pro Val Asp Arg Ile Val Pro Asp 
65                  70                  75                  80  


Phe Ala Ala Ala Gly Ala Ser Ile Ile Thr Phe His Pro Glu Ala Ser 
                85                  90                  95      


Glu His Val Asp Arg Thr Leu Gln Leu Ile Lys Glu Asn Gly Cys Lys 
            100                 105                 110         


Ala Gly Leu Val Phe Asn Pro Ala Thr Pro Leu Ser Tyr Leu Asp Tyr 
        115                 120                 125             


Val Met Asp Lys Leu Asp Val Ile Leu Leu Met Ser Val Asn Pro Gly 
    130                 135                 140                 


Phe Gly Gly Gln Ser Phe Ile Pro Gln Thr Leu Asp Lys Leu Arg Glu 
145                 150                 155                 160 


Val Arg Arg Arg Ile Asp Glu Ser Gly Phe Asp Ile Arg Leu Glu Val 
                165                 170                 175     


Asp Gly Gly Val Lys Val Asn Asn Ile Gly Glu Ile Ala Ala Ala Gly 
            180                 185                 190         


Ala Asp Met Phe Val Ala Gly Ser Ala Ile Phe Asp Gln Pro Asp Tyr 
        195                 200                 205             


Lys Lys Val Ile Asp Glu Met Arg Ser Glu Leu Ala Lys Val Ser His 
    210                 215                 220                 


Glu 
225 


<210>  7
<211>  660
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(660)

<400>  7
atg acg cag gat gaa ttg aaa aaa gca gta gga tgg gcg gca ctt cag         48
Met Thr Gln Asp Glu Leu Lys Lys Ala Val Gly Trp Ala Ala Leu Gln           
1               5                   10                  15                

tat gtt cag ccc ggc acc att gtt ggt gta ggt aca ggt tcc acc gcc         96
Tyr Val Gln Pro Gly Thr Ile Val Gly Val Gly Thr Gly Ser Thr Ala           
            20                  25                  30                    

gca cac ttt att gac gcg ctc ggt aca atg aaa ggc cag att gaa ggg        144
Ala His Phe Ile Asp Ala Leu Gly Thr Met Lys Gly Gln Ile Glu Gly           
        35                  40                  45                        

gcc gtt tcc agt tca gat gct tcc act gaa aaa ctg aaa agc ctc ggc        192
Ala Val Ser Ser Ser Asp Ala Ser Thr Glu Lys Leu Lys Ser Leu Gly           
    50                  55                  60                            

att cac gtt ttt gat ctc aac gaa gtc gac agc ctt ggc atc tac gtt        240
Ile His Val Phe Asp Leu Asn Glu Val Asp Ser Leu Gly Ile Tyr Val           
65                  70                  75                  80            

gat ggc gca gat gaa atc aac ggc cac atg caa atg atc aaa ggc ggc        288
Asp Gly Ala Asp Glu Ile Asn Gly His Met Gln Met Ile Lys Gly Gly           
                85                  90                  95                

ggc gcg gcg ctg acc cgt gaa aaa atc att gct tcg gtt gca gaa aaa        336
Gly Ala Ala Leu Thr Arg Glu Lys Ile Ile Ala Ser Val Ala Glu Lys           
            100                 105                 110                   

ttt atc tgt att gca gac gct tcc aag cag gtt gat att ctg ggt aaa        384
Phe Ile Cys Ile Ala Asp Ala Ser Lys Gln Val Asp Ile Leu Gly Lys           
        115                 120                 125                       

ttc ccg ctg cca gta gaa gtt atc ccg atg gca cgt agt gca gtg gcg        432
Phe Pro Leu Pro Val Glu Val Ile Pro Met Ala Arg Ser Ala Val Ala           
    130                 135                 140                           

cgt cag ctg gtg aaa ctg ggc ggt cgt ccg gaa tac cgt cag ggc gtg        480
Arg Gln Leu Val Lys Leu Gly Gly Arg Pro Glu Tyr Arg Gln Gly Val           
145                 150                 155                 160           

gtg acc gat aat ggc aac gtg atc ctc gac gtc cac ggc atg gaa atc        528
Val Thr Asp Asn Gly Asn Val Ile Leu Asp Val His Gly Met Glu Ile           
                165                 170                 175               

ctt gac ccg ata gcg atg gaa aac gcc ata aat gcg att cct ggc gtg        576
Leu Asp Pro Ile Ala Met Glu Asn Ala Ile Asn Ala Ile Pro Gly Val           
            180                 185                 190                   

gtg act gtt ggc ttg ttt gct aac cgt ggc gcg gac gtt gcg ctg att        624
Val Thr Val Gly Leu Phe Ala Asn Arg Gly Ala Asp Val Ala Leu Ile           
        195                 200                 205                       

ggc aca cct gac ggt gtc aaa acc att gtg aaa tga                        660
Gly Thr Pro Asp Gly Val Lys Thr Ile Val Lys                               
    210                 215                                               


<210>  8
<211>  219
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Thr Gln Asp Glu Leu Lys Lys Ala Val Gly Trp Ala Ala Leu Gln 
1               5                   10                  15      


Tyr Val Gln Pro Gly Thr Ile Val Gly Val Gly Thr Gly Ser Thr Ala 
            20                  25                  30          


Ala His Phe Ile Asp Ala Leu Gly Thr Met Lys Gly Gln Ile Glu Gly 
        35                  40                  45              


Ala Val Ser Ser Ser Asp Ala Ser Thr Glu Lys Leu Lys Ser Leu Gly 
    50                  55                  60                  


Ile His Val Phe Asp Leu Asn Glu Val Asp Ser Leu Gly Ile Tyr Val 
65                  70                  75                  80  


Asp Gly Ala Asp Glu Ile Asn Gly His Met Gln Met Ile Lys Gly Gly 
                85                  90                  95      


Gly Ala Ala Leu Thr Arg Glu Lys Ile Ile Ala Ser Val Ala Glu Lys 
            100                 105                 110         


Phe Ile Cys Ile Ala Asp Ala Ser Lys Gln Val Asp Ile Leu Gly Lys 
        115                 120                 125             


Phe Pro Leu Pro Val Glu Val Ile Pro Met Ala Arg Ser Ala Val Ala 
    130                 135                 140                 


Arg Gln Leu Val Lys Leu Gly Gly Arg Pro Glu Tyr Arg Gln Gly Val 
145                 150                 155                 160 


Val Thr Asp Asn Gly Asn Val Ile Leu Asp Val His Gly Met Glu Ile 
                165                 170                 175     


Leu Asp Pro Ile Ala Met Glu Asn Ala Ile Asn Ala Ile Pro Gly Val 
            180                 185                 190         


Val Thr Val Gly Leu Phe Ala Asn Arg Gly Ala Asp Val Ala Leu Ile 
        195                 200                 205             


Gly Thr Pro Asp Gly Val Lys Thr Ile Val Lys 
    210                 215                 


<210>  9
<211>  954
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(954)

<400>  9
atg acg gac aaa ttg acc tcc ctt cgt cag tac acc acc gta gtg gcc         48
Met Thr Asp Lys Leu Thr Ser Leu Arg Gln Tyr Thr Thr Val Val Ala           
1               5                   10                  15                

gac act ggg gac atc gcg gca atg aag ctg tat caa ccg cag gat gcc         96
Asp Thr Gly Asp Ile Ala Ala Met Lys Leu Tyr Gln Pro Gln Asp Ala           
            20                  25                  30                    

aca acc aac cct tct ctc att ctt aac gca gcg cag att ccg gaa tac        144
Thr Thr Asn Pro Ser Leu Ile Leu Asn Ala Ala Gln Ile Pro Glu Tyr           
        35                  40                  45                        

cgt aag ttg att gat gat gct gtc gcc tgg gcg aaa cag cag agc aac        192
Arg Lys Leu Ile Asp Asp Ala Val Ala Trp Ala Lys Gln Gln Ser Asn           
    50                  55                  60                            

gat cgc gcg cag cag atc gtg gac gcg acc gac aaa ctg gca gta aat        240
Asp Arg Ala Gln Gln Ile Val Asp Ala Thr Asp Lys Leu Ala Val Asn           
65                  70                  75                  80            

att ggt ctg gaa atc ctg aaa ctg gtt ccg ggc cgt atc tca act gaa        288
Ile Gly Leu Glu Ile Leu Lys Leu Val Pro Gly Arg Ile Ser Thr Glu           
                85                  90                  95                

gtt gat gcg cgt ctt tcc tat gac acc gaa gcg tca att gcg aaa gca        336
Val Asp Ala Arg Leu Ser Tyr Asp Thr Glu Ala Ser Ile Ala Lys Ala           
            100                 105                 110                   

aaa cgc ctg atc aaa ctc tac aac gat gct ggt att agc aac gat cgt        384
Lys Arg Leu Ile Lys Leu Tyr Asn Asp Ala Gly Ile Ser Asn Asp Arg           
        115                 120                 125                       

att ctg atc aaa ctg gct tct acc tgg cag ggt atc cgt gct gca gaa        432
Ile Leu Ile Lys Leu Ala Ser Thr Trp Gln Gly Ile Arg Ala Ala Glu           
    130                 135                 140                           

cag ctg gaa aaa gaa ggc atc aac tgt aac ctg acc ctg ctg ttc tcc        480
Gln Leu Glu Lys Glu Gly Ile Asn Cys Asn Leu Thr Leu Leu Phe Ser           
145                 150                 155                 160           

ttc gct cag gct cgt gct tgt gcg gaa gcg ggc gtg ttc ctg atc tcg        528
Phe Ala Gln Ala Arg Ala Cys Ala Glu Ala Gly Val Phe Leu Ile Ser           
                165                 170                 175               

ccg ttt gtt ggc cgt att ctt gac tgg tac aaa gcg aat acc gat aag        576
Pro Phe Val Gly Arg Ile Leu Asp Trp Tyr Lys Ala Asn Thr Asp Lys           
            180                 185                 190                   

aaa gag tac gct ccg gca gaa gat ccg ggc gtg gtt tct gta tct gaa        624
Lys Glu Tyr Ala Pro Ala Glu Asp Pro Gly Val Val Ser Val Ser Glu           
        195                 200                 205                       

atc tac cag tac tac aaa gag cac ggt tat gaa acc gtg gtt atg ggc        672
Ile Tyr Gln Tyr Tyr Lys Glu His Gly Tyr Glu Thr Val Val Met Gly           
    210                 215                 220                           

gca agc ttc cgt aac atc ggc gaa att ctg gaa ctg gca ggc tgc gac        720
Ala Ser Phe Arg Asn Ile Gly Glu Ile Leu Glu Leu Ala Gly Cys Asp           
225                 230                 235                 240           

cgt ctg acc atc gca ccg gca ctg ctg aaa gag ctg gcg gag agc gaa        768
Arg Leu Thr Ile Ala Pro Ala Leu Leu Lys Glu Leu Ala Glu Ser Glu           
                245                 250                 255               

ggg gct atc gaa cgt aaa ctg tct tac acc ggc gaa gtg aaa gcg cgt        816
Gly Ala Ile Glu Arg Lys Leu Ser Tyr Thr Gly Glu Val Lys Ala Arg           
            260                 265                 270                   

ccg gcg cgt atc act gag tcc gag ttc ctg tgg cag cac aac cag gat        864
Pro Ala Arg Ile Thr Glu Ser Glu Phe Leu Trp Gln His Asn Gln Asp           
        275                 280                 285                       

cca atg gca gta gat aaa ctg gcg gaa ggt atc cgt aag ttt gct att        912
Pro Met Ala Val Asp Lys Leu Ala Glu Gly Ile Arg Lys Phe Ala Ile           
    290                 295                 300                           

gac cag gaa aaa ctg gaa aaa atg atc ggc gat ctg ctg taa                954
Asp Gln Glu Lys Leu Glu Lys Met Ile Gly Asp Leu Leu                       
305                 310                 315                               


<210>  10
<211>  317
<212>  PRT
<213>  Escherichia coli

<400>  10

Met Thr Asp Lys Leu Thr Ser Leu Arg Gln Tyr Thr Thr Val Val Ala 
1               5                   10                  15      


Asp Thr Gly Asp Ile Ala Ala Met Lys Leu Tyr Gln Pro Gln Asp Ala 
            20                  25                  30          


Thr Thr Asn Pro Ser Leu Ile Leu Asn Ala Ala Gln Ile Pro Glu Tyr 
        35                  40                  45              


Arg Lys Leu Ile Asp Asp Ala Val Ala Trp Ala Lys Gln Gln Ser Asn 
    50                  55                  60                  


Asp Arg Ala Gln Gln Ile Val Asp Ala Thr Asp Lys Leu Ala Val Asn 
65                  70                  75                  80  


Ile Gly Leu Glu Ile Leu Lys Leu Val Pro Gly Arg Ile Ser Thr Glu 
                85                  90                  95      


Val Asp Ala Arg Leu Ser Tyr Asp Thr Glu Ala Ser Ile Ala Lys Ala 
            100                 105                 110         


Lys Arg Leu Ile Lys Leu Tyr Asn Asp Ala Gly Ile Ser Asn Asp Arg 
        115                 120                 125             


Ile Leu Ile Lys Leu Ala Ser Thr Trp Gln Gly Ile Arg Ala Ala Glu 
    130                 135                 140                 


Gln Leu Glu Lys Glu Gly Ile Asn Cys Asn Leu Thr Leu Leu Phe Ser 
145                 150                 155                 160 


Phe Ala Gln Ala Arg Ala Cys Ala Glu Ala Gly Val Phe Leu Ile Ser 
                165                 170                 175     


Pro Phe Val Gly Arg Ile Leu Asp Trp Tyr Lys Ala Asn Thr Asp Lys 
            180                 185                 190         


Lys Glu Tyr Ala Pro Ala Glu Asp Pro Gly Val Val Ser Val Ser Glu 
        195                 200                 205             


Ile Tyr Gln Tyr Tyr Lys Glu His Gly Tyr Glu Thr Val Val Met Gly 
    210                 215                 220                 


Ala Ser Phe Arg Asn Ile Gly Glu Ile Leu Glu Leu Ala Gly Cys Asp 
225                 230                 235                 240 


Arg Leu Thr Ile Ala Pro Ala Leu Leu Lys Glu Leu Ala Glu Ser Glu 
                245                 250                 255     


Gly Ala Ile Glu Arg Lys Leu Ser Tyr Thr Gly Glu Val Lys Ala Arg 
            260                 265                 270         


Pro Ala Arg Ile Thr Glu Ser Glu Phe Leu Trp Gln His Asn Gln Asp 
        275                 280                 285             


Pro Met Ala Val Asp Lys Leu Ala Glu Gly Ile Arg Lys Phe Ala Ile 
    290                 295                 300                 


Asp Gln Glu Lys Leu Glu Lys Met Ile Gly Asp Leu Leu 
305                 310                 315         


<210>  11
<211>  1992
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(1992)

<400>  11
atg tcc tca cgt aaa gag ctt gcc aat gct att cgt gcg ctg agc atg         48
Met Ser Ser Arg Lys Glu Leu Ala Asn Ala Ile Arg Ala Leu Ser Met           
1               5                   10                  15                

gac gca gta cag aaa gcc aaa tcc ggt cac ccg ggt gcc cct atg ggt         96
Asp Ala Val Gln Lys Ala Lys Ser Gly His Pro Gly Ala Pro Met Gly           
            20                  25                  30                    

atg gct gac att gcc gaa gtc ctg tgg cgt gat ttc ctg aaa cac aac        144
Met Ala Asp Ile Ala Glu Val Leu Trp Arg Asp Phe Leu Lys His Asn           
        35                  40                  45                        

ccg cag aat ccg tcc tgg gct gac cgt gac cgc ttc gtg ctg tcc aac        192
Pro Gln Asn Pro Ser Trp Ala Asp Arg Asp Arg Phe Val Leu Ser Asn           
    50                  55                  60                            

ggc cac ggc tcc atg ctg atc tac agc ctg ctg cac ctc acc ggt tac        240
Gly His Gly Ser Met Leu Ile Tyr Ser Leu Leu His Leu Thr Gly Tyr           
65                  70                  75                  80            

gat ctg ccg atg gaa gaa ctg aaa aac ttc cgt cag ctg cac tct aaa        288
Asp Leu Pro Met Glu Glu Leu Lys Asn Phe Arg Gln Leu His Ser Lys           
                85                  90                  95                

act ccg ggt cac ccg gaa gtg ggt tac acc gct ggt gtg gaa acc acc        336
Thr Pro Gly His Pro Glu Val Gly Tyr Thr Ala Gly Val Glu Thr Thr           
            100                 105                 110                   

acc ggt ccg ctg ggt cag ggt att gcc aac gca gtc ggt atg gcg att        384
Thr Gly Pro Leu Gly Gln Gly Ile Ala Asn Ala Val Gly Met Ala Ile           
        115                 120                 125                       

gca gaa aaa acg ctg gcg gcg cag ttt aac cgt ccg ggc cac gac att        432
Ala Glu Lys Thr Leu Ala Ala Gln Phe Asn Arg Pro Gly His Asp Ile           
    130                 135                 140                           

gtc gac cac tac acc tac gcc ttc atg ggc gac ggc tgc atg atg gaa        480
Val Asp His Tyr Thr Tyr Ala Phe Met Gly Asp Gly Cys Met Met Glu           
145                 150                 155                 160           

ggc atc tcc cac gaa gtt tgc tct ctg gcg ggt acg ctg aag ctg ggt        528
Gly Ile Ser His Glu Val Cys Ser Leu Ala Gly Thr Leu Lys Leu Gly           
                165                 170                 175               

aaa ctg att gca ttc tac gat gac aac ggt att tct atc gat ggt cac        576
Lys Leu Ile Ala Phe Tyr Asp Asp Asn Gly Ile Ser Ile Asp Gly His           
            180                 185                 190                   

gtt gaa ggc tgg ttc acc gac gac acc gca atg cgt ttc gaa gct tac        624
Val Glu Gly Trp Phe Thr Asp Asp Thr Ala Met Arg Phe Glu Ala Tyr           
        195                 200                 205                       

ggc tgg cac gtt att cgc gac atc gac ggt cat gac gcg gca tct atc        672
Gly Trp His Val Ile Arg Asp Ile Asp Gly His Asp Ala Ala Ser Ile           
    210                 215                 220                           

aaa cgc gca gta gaa gaa gcg cgc gca gtg act gac aaa cct tcc ctg        720
Lys Arg Ala Val Glu Glu Ala Arg Ala Val Thr Asp Lys Pro Ser Leu           
225                 230                 235                 240           

ctg atg tgc aaa acc atc atc ggt ttc ggt tcc ccg aac aaa gcc ggt        768
Leu Met Cys Lys Thr Ile Ile Gly Phe Gly Ser Pro Asn Lys Ala Gly           
                245                 250                 255               

acc cac gac tcc cac ggt gcg ccg ctg ggc gac gct gaa att gcc ctg        816
Thr His Asp Ser His Gly Ala Pro Leu Gly Asp Ala Glu Ile Ala Leu           
            260                 265                 270                   

acc cgc gaa caa ctg ggc tgg aaa tat gcg ccg ttc gaa atc ccg tct        864
Thr Arg Glu Gln Leu Gly Trp Lys Tyr Ala Pro Phe Glu Ile Pro Ser           
        275                 280                 285                       

gaa atc tat gct cag tgg gat gcg aaa gaa gca ggc cag gcg aaa gaa        912
Glu Ile Tyr Ala Gln Trp Asp Ala Lys Glu Ala Gly Gln Ala Lys Glu           
    290                 295                 300                           

tcc gca tgg aac gag aaa ttc gct gct tac gcg aaa gct tat ccg cag        960
Ser Ala Trp Asn Glu Lys Phe Ala Ala Tyr Ala Lys Ala Tyr Pro Gln           
305                 310                 315                 320           

gaa gcc gct gaa ttt acc cgc cgt atg aaa ggc gaa atg ccg tct gac       1008
Glu Ala Ala Glu Phe Thr Arg Arg Met Lys Gly Glu Met Pro Ser Asp           
                325                 330                 335               

ttc gac gct aaa gcg aaa gag ttc atc gct aaa ctg cag gct aat ccg       1056
Phe Asp Ala Lys Ala Lys Glu Phe Ile Ala Lys Leu Gln Ala Asn Pro           
            340                 345                 350                   

gcg aaa atc gcc agc cgt aaa gcg tct cag aat gct atc gaa gcg ttc       1104
Ala Lys Ile Ala Ser Arg Lys Ala Ser Gln Asn Ala Ile Glu Ala Phe           
        355                 360                 365                       

ggt ccg ctg ttg ccg gaa ttc ctc ggc ggt tct gct gac ctg gcg ccg       1152
Gly Pro Leu Leu Pro Glu Phe Leu Gly Gly Ser Ala Asp Leu Ala Pro           
    370                 375                 380                           

tct aac ctg acc ctg tgg tct ggt tct aaa gca atc aac gaa gat gct       1200
Ser Asn Leu Thr Leu Trp Ser Gly Ser Lys Ala Ile Asn Glu Asp Ala           
385                 390                 395                 400           

gcg ggt aac tac atc cac tac ggt gtt cgc gag ttc ggt atg acc gcg       1248
Ala Gly Asn Tyr Ile His Tyr Gly Val Arg Glu Phe Gly Met Thr Ala           
                405                 410                 415               

att gct aac ggt atc tcc ctg cac ggt ggc ttc ctg ccg tac acc tcc       1296
Ile Ala Asn Gly Ile Ser Leu His Gly Gly Phe Leu Pro Tyr Thr Ser           
            420                 425                 430                   

acc ttc ctg atg ttc gtg gaa tac gca cgt aac gcc gta cgt atg gct       1344
Thr Phe Leu Met Phe Val Glu Tyr Ala Arg Asn Ala Val Arg Met Ala           
        435                 440                 445                       

gcg ctg atg aaa cag cgt cag gtg atg gtt tac acc cac gac tcc atc       1392
Ala Leu Met Lys Gln Arg Gln Val Met Val Tyr Thr His Asp Ser Ile           
    450                 455                 460                           

ggt ctg ggc gaa gac ggc ccg act cac cag ccg gtt gag cag gtc gct       1440
Gly Leu Gly Glu Asp Gly Pro Thr His Gln Pro Val Glu Gln Val Ala           
465                 470                 475                 480           

tct ctg cgc gta acc ccg aac atg tct aca tgg cgt ccg tgt gac cag       1488
Ser Leu Arg Val Thr Pro Asn Met Ser Thr Trp Arg Pro Cys Asp Gln           
                485                 490                 495               

gtt gaa tcc gcg gtc gcg tgg aaa tac ggt gtt gag cgt cag gac ggc       1536
Val Glu Ser Ala Val Ala Trp Lys Tyr Gly Val Glu Arg Gln Asp Gly           
            500                 505                 510                   

ccg acc gca ctg atc ctc tcc cgt cag aac ctg gcg cag cag gaa cga       1584
Pro Thr Ala Leu Ile Leu Ser Arg Gln Asn Leu Ala Gln Gln Glu Arg           
        515                 520                 525                       

act gaa gag caa ctg gca aac atc gcg cgc ggt ggt tat gtg ctg aaa       1632
Thr Glu Glu Gln Leu Ala Asn Ile Ala Arg Gly Gly Tyr Val Leu Lys           
    530                 535                 540                           

gac tgc gcc ggt cag ccg gaa ctg att ttc atc gct acc ggt tca gaa       1680
Asp Cys Ala Gly Gln Pro Glu Leu Ile Phe Ile Ala Thr Gly Ser Glu           
545                 550                 555                 560           

gtt gaa ctg gct gtt gct gcc tac gaa aaa ctg act gcc gaa ggc gtg       1728
Val Glu Leu Ala Val Ala Ala Tyr Glu Lys Leu Thr Ala Glu Gly Val           
                565                 570                 575               

aaa gcg cgc gtg gtg tcc atg ccg tct acc gac gca ttt gac aag cag       1776
Lys Ala Arg Val Val Ser Met Pro Ser Thr Asp Ala Phe Asp Lys Gln           
            580                 585                 590                   

gat gct gct tac cgt gaa tcc gta ctg ccg aaa gcg gtt act gca cgc       1824
Asp Ala Ala Tyr Arg Glu Ser Val Leu Pro Lys Ala Val Thr Ala Arg           
        595                 600                 605                       

gtt gct gta gaa gcg ggt att gct gac tac tgg tac aag tat gtt ggc       1872
Val Ala Val Glu Ala Gly Ile Ala Asp Tyr Trp Tyr Lys Tyr Val Gly           
    610                 615                 620                           

ctg aac ggt gct atc gtc ggt atg acc acc ttc ggt gaa tct gct ccg       1920
Leu Asn Gly Ala Ile Val Gly Met Thr Thr Phe Gly Glu Ser Ala Pro           
625                 630                 635                 640           

gca gag ctg ctg ttt gaa gag ttc ggc ttc act gtt gat aac gtt gtt       1968
Ala Glu Leu Leu Phe Glu Glu Phe Gly Phe Thr Val Asp Asn Val Val           
                645                 650                 655               

gcg aaa gca aaa gaa ctg ctg taa                                       1992
Ala Lys Ala Lys Glu Leu Leu                                               
            660                                                           


<210>  12
<211>  663
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Ser Ser Arg Lys Glu Leu Ala Asn Ala Ile Arg Ala Leu Ser Met 
1               5                   10                  15      


Asp Ala Val Gln Lys Ala Lys Ser Gly His Pro Gly Ala Pro Met Gly 
            20                  25                  30          


Met Ala Asp Ile Ala Glu Val Leu Trp Arg Asp Phe Leu Lys His Asn 
        35                  40                  45              


Pro Gln Asn Pro Ser Trp Ala Asp Arg Asp Arg Phe Val Leu Ser Asn 
    50                  55                  60                  


Gly His Gly Ser Met Leu Ile Tyr Ser Leu Leu His Leu Thr Gly Tyr 
65                  70                  75                  80  


Asp Leu Pro Met Glu Glu Leu Lys Asn Phe Arg Gln Leu His Ser Lys 
                85                  90                  95      


Thr Pro Gly His Pro Glu Val Gly Tyr Thr Ala Gly Val Glu Thr Thr 
            100                 105                 110         


Thr Gly Pro Leu Gly Gln Gly Ile Ala Asn Ala Val Gly Met Ala Ile 
        115                 120                 125             


Ala Glu Lys Thr Leu Ala Ala Gln Phe Asn Arg Pro Gly His Asp Ile 
    130                 135                 140                 


Val Asp His Tyr Thr Tyr Ala Phe Met Gly Asp Gly Cys Met Met Glu 
145                 150                 155                 160 


Gly Ile Ser His Glu Val Cys Ser Leu Ala Gly Thr Leu Lys Leu Gly 
                165                 170                 175     


Lys Leu Ile Ala Phe Tyr Asp Asp Asn Gly Ile Ser Ile Asp Gly His 
            180                 185                 190         


Val Glu Gly Trp Phe Thr Asp Asp Thr Ala Met Arg Phe Glu Ala Tyr 
        195                 200                 205             


Gly Trp His Val Ile Arg Asp Ile Asp Gly His Asp Ala Ala Ser Ile 
    210                 215                 220                 


Lys Arg Ala Val Glu Glu Ala Arg Ala Val Thr Asp Lys Pro Ser Leu 
225                 230                 235                 240 


Leu Met Cys Lys Thr Ile Ile Gly Phe Gly Ser Pro Asn Lys Ala Gly 
                245                 250                 255     


Thr His Asp Ser His Gly Ala Pro Leu Gly Asp Ala Glu Ile Ala Leu 
            260                 265                 270         


Thr Arg Glu Gln Leu Gly Trp Lys Tyr Ala Pro Phe Glu Ile Pro Ser 
        275                 280                 285             


Glu Ile Tyr Ala Gln Trp Asp Ala Lys Glu Ala Gly Gln Ala Lys Glu 
    290                 295                 300                 


Ser Ala Trp Asn Glu Lys Phe Ala Ala Tyr Ala Lys Ala Tyr Pro Gln 
305                 310                 315                 320 


Glu Ala Ala Glu Phe Thr Arg Arg Met Lys Gly Glu Met Pro Ser Asp 
                325                 330                 335     


Phe Asp Ala Lys Ala Lys Glu Phe Ile Ala Lys Leu Gln Ala Asn Pro 
            340                 345                 350         


Ala Lys Ile Ala Ser Arg Lys Ala Ser Gln Asn Ala Ile Glu Ala Phe 
        355                 360                 365             


Gly Pro Leu Leu Pro Glu Phe Leu Gly Gly Ser Ala Asp Leu Ala Pro 
    370                 375                 380                 


Ser Asn Leu Thr Leu Trp Ser Gly Ser Lys Ala Ile Asn Glu Asp Ala 
385                 390                 395                 400 


Ala Gly Asn Tyr Ile His Tyr Gly Val Arg Glu Phe Gly Met Thr Ala 
                405                 410                 415     


Ile Ala Asn Gly Ile Ser Leu His Gly Gly Phe Leu Pro Tyr Thr Ser 
            420                 425                 430         


Thr Phe Leu Met Phe Val Glu Tyr Ala Arg Asn Ala Val Arg Met Ala 
        435                 440                 445             


Ala Leu Met Lys Gln Arg Gln Val Met Val Tyr Thr His Asp Ser Ile 
    450                 455                 460                 


Gly Leu Gly Glu Asp Gly Pro Thr His Gln Pro Val Glu Gln Val Ala 
465                 470                 475                 480 


Ser Leu Arg Val Thr Pro Asn Met Ser Thr Trp Arg Pro Cys Asp Gln 
                485                 490                 495     


Val Glu Ser Ala Val Ala Trp Lys Tyr Gly Val Glu Arg Gln Asp Gly 
            500                 505                 510         


Pro Thr Ala Leu Ile Leu Ser Arg Gln Asn Leu Ala Gln Gln Glu Arg 
        515                 520                 525             


Thr Glu Glu Gln Leu Ala Asn Ile Ala Arg Gly Gly Tyr Val Leu Lys 
    530                 535                 540                 


Asp Cys Ala Gly Gln Pro Glu Leu Ile Phe Ile Ala Thr Gly Ser Glu 
545                 550                 555                 560 


Val Glu Leu Ala Val Ala Ala Tyr Glu Lys Leu Thr Ala Glu Gly Val 
                565                 570                 575     


Lys Ala Arg Val Val Ser Met Pro Ser Thr Asp Ala Phe Asp Lys Gln 
            580                 585                 590         


Asp Ala Ala Tyr Arg Glu Ser Val Leu Pro Lys Ala Val Thr Ala Arg 
        595                 600                 605             


Val Ala Val Glu Ala Gly Ile Ala Asp Tyr Trp Tyr Lys Tyr Val Gly 
    610                 615                 620                 


Leu Asn Gly Ala Ile Val Gly Met Thr Thr Phe Gly Glu Ser Ala Pro 
625                 630                 635                 640 


Ala Glu Leu Leu Phe Glu Glu Phe Gly Phe Thr Val Asp Asn Val Val 
                645                 650                 655     


Ala Lys Ala Lys Glu Leu Leu 
            660             


<210>  13
<211>  768
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(768)

<400>  13
atg cga cat cct tta gtg atg ggt aac tgg aaa ctg aac ggc agc cgc         48
Met Arg His Pro Leu Val Met Gly Asn Trp Lys Leu Asn Gly Ser Arg           
1               5                   10                  15                

cac atg gtt cac gag ctg gtt tct aac ctg cgt aaa gag ctg gca ggt         96
His Met Val His Glu Leu Val Ser Asn Leu Arg Lys Glu Leu Ala Gly           
            20                  25                  30                    

gtt gct ggc tgt gcg gtt gca atc gca cca ccg gaa atg tat atc gat        144
Val Ala Gly Cys Ala Val Ala Ile Ala Pro Pro Glu Met Tyr Ile Asp           
        35                  40                  45                        

atg gcg aag cgc gaa gct gaa ggc agc cac atc atg ctg ggt gcg caa        192
Met Ala Lys Arg Glu Ala Glu Gly Ser His Ile Met Leu Gly Ala Gln           
    50                  55                  60                            

aac gtg gac ctg aac ctg tcc ggc gca ttc acc ggt gaa acc tct gct        240
Asn Val Asp Leu Asn Leu Ser Gly Ala Phe Thr Gly Glu Thr Ser Ala           
65                  70                  75                  80            

gct atg ctg aaa gac atc ggc gca cag tac atc atc atc ggt cac tct        288
Ala Met Leu Lys Asp Ile Gly Ala Gln Tyr Ile Ile Ile Gly His Ser           
                85                  90                  95                

gaa cgt cgt act tac cac aaa gaa tct gac gaa ctg atc gcg aaa aaa        336
Glu Arg Arg Thr Tyr His Lys Glu Ser Asp Glu Leu Ile Ala Lys Lys           
            100                 105                 110                   

ttc gcg gtg ctg aaa gag cag ggc ctg act ccg gtt ctg tgc atc ggt        384
Phe Ala Val Leu Lys Glu Gln Gly Leu Thr Pro Val Leu Cys Ile Gly           
        115                 120                 125                       

gaa acc gaa gct gaa aat gaa gcg ggc aaa act gaa gaa gtt tgc gca        432
Glu Thr Glu Ala Glu Asn Glu Ala Gly Lys Thr Glu Glu Val Cys Ala           
    130                 135                 140                           

cgt cag atc gac gcg gta ctg aaa act cag ggt gct gcg gca ttc gaa        480
Arg Gln Ile Asp Ala Val Leu Lys Thr Gln Gly Ala Ala Ala Phe Glu           
145                 150                 155                 160           

ggt gcg gtt atc gct tac gaa cct gta tgg gca atc ggt act ggc aaa        528
Gly Ala Val Ile Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys           
                165                 170                 175               

tct gca act ccg gct cag gca cag gct gtt cac aaa ttc atc cgt gac        576
Ser Ala Thr Pro Ala Gln Ala Gln Ala Val His Lys Phe Ile Arg Asp           
            180                 185                 190                   

cac atc gct aaa gtt gac gct aac atc gct gaa caa gtg atc att cag        624
His Ile Ala Lys Val Asp Ala Asn Ile Ala Glu Gln Val Ile Ile Gln           
        195                 200                 205                       

tac ggc ggc tct gta aac gcg tct aac gct gca gaa ctg ttt gct cag        672
Tyr Gly Gly Ser Val Asn Ala Ser Asn Ala Ala Glu Leu Phe Ala Gln           
    210                 215                 220                           

ccg gat atc gac ggc gcg ctg gtt ggt ggt gct tct ctg aaa gct gac        720
Pro Asp Ile Asp Gly Ala Leu Val Gly Gly Ala Ser Leu Lys Ala Asp           
225                 230                 235                 240           

gcc ttc gca gta atc gtt aaa gct gca gaa gcg gct aaa cag gct taa        768
Ala Phe Ala Val Ile Val Lys Ala Ala Glu Ala Ala Lys Gln Ala               
                245                 250                 255               


<210>  14
<211>  255
<212>  PRT
<213>  Escherichia coli

<400>  14

Met Arg His Pro Leu Val Met Gly Asn Trp Lys Leu Asn Gly Ser Arg 
1               5                   10                  15      


His Met Val His Glu Leu Val Ser Asn Leu Arg Lys Glu Leu Ala Gly 
            20                  25                  30          


Val Ala Gly Cys Ala Val Ala Ile Ala Pro Pro Glu Met Tyr Ile Asp 
        35                  40                  45              


Met Ala Lys Arg Glu Ala Glu Gly Ser His Ile Met Leu Gly Ala Gln 
    50                  55                  60                  


Asn Val Asp Leu Asn Leu Ser Gly Ala Phe Thr Gly Glu Thr Ser Ala 
65                  70                  75                  80  


Ala Met Leu Lys Asp Ile Gly Ala Gln Tyr Ile Ile Ile Gly His Ser 
                85                  90                  95      


Glu Arg Arg Thr Tyr His Lys Glu Ser Asp Glu Leu Ile Ala Lys Lys 
            100                 105                 110         


Phe Ala Val Leu Lys Glu Gln Gly Leu Thr Pro Val Leu Cys Ile Gly 
        115                 120                 125             


Glu Thr Glu Ala Glu Asn Glu Ala Gly Lys Thr Glu Glu Val Cys Ala 
    130                 135                 140                 


Arg Gln Ile Asp Ala Val Leu Lys Thr Gln Gly Ala Ala Ala Phe Glu 
145                 150                 155                 160 


Gly Ala Val Ile Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys 
                165                 170                 175     


Ser Ala Thr Pro Ala Gln Ala Gln Ala Val His Lys Phe Ile Arg Asp 
            180                 185                 190         


His Ile Ala Lys Val Asp Ala Asn Ile Ala Glu Gln Val Ile Ile Gln 
        195                 200                 205             


Tyr Gly Gly Ser Val Asn Ala Ser Asn Ala Ala Glu Leu Phe Ala Gln 
    210                 215                 220                 


Pro Asp Ile Asp Gly Ala Leu Val Gly Gly Ala Ser Leu Lys Ala Asp 
225                 230                 235                 240 


Ala Phe Ala Val Ile Val Lys Ala Ala Glu Ala Ala Lys Gln Ala 
                245                 250                 255 


<210>  15
<211>  1080
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(1080)

<400>  15
atg tct aag att ttt gat ttc gta aaa cct ggc gta atc act ggt gat         48
Met Ser Lys Ile Phe Asp Phe Val Lys Pro Gly Val Ile Thr Gly Asp           
1               5                   10                  15                

gac gta cag aaa gtt ttc cag gta gca aaa gaa aac aac ttc gca ctg         96
Asp Val Gln Lys Val Phe Gln Val Ala Lys Glu Asn Asn Phe Ala Leu           
            20                  25                  30                    

cca gca gta aac tgc gtc ggt act gac tcc atc aac gcc gta ctg gaa        144
Pro Ala Val Asn Cys Val Gly Thr Asp Ser Ile Asn Ala Val Leu Glu           
        35                  40                  45                        

acc gct gct aaa gtt aaa gcg ccg gtt atc gtt cag ttc tcc aac ggt        192
Thr Ala Ala Lys Val Lys Ala Pro Val Ile Val Gln Phe Ser Asn Gly           
    50                  55                  60                            

ggt gct tcc ttt atc gct ggt aaa ggc gtg aaa tct gac gtt ccg cag        240
Gly Ala Ser Phe Ile Ala Gly Lys Gly Val Lys Ser Asp Val Pro Gln           
65                  70                  75                  80            

ggt gct gct atc ctg ggc gcg atc tct ggt gcg cat cac gtt cac cag        288
Gly Ala Ala Ile Leu Gly Ala Ile Ser Gly Ala His His Val His Gln           
                85                  90                  95                

atg gct gaa cat tat ggt gtt ccg gtt atc ctg cac act gac cac tgc        336
Met Ala Glu His Tyr Gly Val Pro Val Ile Leu His Thr Asp His Cys           
            100                 105                 110                   

gcg aag aaa ctg ctg ccg tgg atc gac ggt ctg ttg gac gcg ggt gaa        384
Ala Lys Lys Leu Leu Pro Trp Ile Asp Gly Leu Leu Asp Ala Gly Glu           
        115                 120                 125                       

aaa cac ttc gca gct acc ggt aag ccg ctg ttc tct tct cac atg atc        432
Lys His Phe Ala Ala Thr Gly Lys Pro Leu Phe Ser Ser His Met Ile           
    130                 135                 140                           

gac ctg tct gaa gaa tct ctg caa gag aac atc gaa atc tgc tct aaa        480
Asp Leu Ser Glu Glu Ser Leu Gln Glu Asn Ile Glu Ile Cys Ser Lys           
145                 150                 155                 160           

tac ctg gag cgc atg tcc aaa atc ggc atg act ctg gaa atc gaa ctg        528
Tyr Leu Glu Arg Met Ser Lys Ile Gly Met Thr Leu Glu Ile Glu Leu           
                165                 170                 175               

ggt tgc acc ggt ggt gaa gaa gac ggc gtg gac aac agc cac atg gac        576
Gly Cys Thr Gly Gly Glu Glu Asp Gly Val Asp Asn Ser His Met Asp           
            180                 185                 190                   

gct tct gca ctg tac acc cag ccg gaa gac gtt gat tac gca tac acc        624
Ala Ser Ala Leu Tyr Thr Gln Pro Glu Asp Val Asp Tyr Ala Tyr Thr           
        195                 200                 205                       

gaa ctg agc aaa atc agc ccg cgt ttc acc atc gca gcg tcc ttc ggt        672
Glu Leu Ser Lys Ile Ser Pro Arg Phe Thr Ile Ala Ala Ser Phe Gly           
    210                 215                 220                           

aac gta cac ggt gtt tac aag ccg ggt aac gtg gtt ctg act ccg acc        720
Asn Val His Gly Val Tyr Lys Pro Gly Asn Val Val Leu Thr Pro Thr           
225                 230                 235                 240           

atc ctg cgt gat tct cag gaa tat gtt tcc aag aaa cac aac ctg ccg        768
Ile Leu Arg Asp Ser Gln Glu Tyr Val Ser Lys Lys His Asn Leu Pro           
                245                 250                 255               

cac aac agc ctg aac ttc gta ttc cac ggt ggt tcc ggt tct act gct        816
His Asn Ser Leu Asn Phe Val Phe His Gly Gly Ser Gly Ser Thr Ala           
            260                 265                 270                   

cag gaa atc aaa gac tcc gta agc tac ggc gta gta aaa atg aac atc        864
Gln Glu Ile Lys Asp Ser Val Ser Tyr Gly Val Val Lys Met Asn Ile           
        275                 280                 285                       

gat acc gat acc caa tgg gca acc tgg gaa ggc gtt ctg aac tac tac        912
Asp Thr Asp Thr Gln Trp Ala Thr Trp Glu Gly Val Leu Asn Tyr Tyr           
    290                 295                 300                           

aaa gcg aac gaa gct tat ctg cag ggt cag ctg ggt aac ccg aaa ggc        960
Lys Ala Asn Glu Ala Tyr Leu Gln Gly Gln Leu Gly Asn Pro Lys Gly           
305                 310                 315                 320           

gaa gat cag ccg aac aag aaa tac tac gat ccg cgc gta tgg ctg cgt       1008
Glu Asp Gln Pro Asn Lys Lys Tyr Tyr Asp Pro Arg Val Trp Leu Arg           
                325                 330                 335               

gcc ggt cag act tcg atg atc gct cgt ctg gag aaa gca ttc cag gaa       1056
Ala Gly Gln Thr Ser Met Ile Ala Arg Leu Glu Lys Ala Phe Gln Glu           
            340                 345                 350                   

ctg aac gcg atc gac gtt ctg taa                                       1080
Leu Asn Ala Ile Asp Val Leu                                               
        355                                                               


<210>  16
<211>  359
<212>  PRT
<213>  Escherichia coli

<400>  16

Met Ser Lys Ile Phe Asp Phe Val Lys Pro Gly Val Ile Thr Gly Asp 
1               5                   10                  15      


Asp Val Gln Lys Val Phe Gln Val Ala Lys Glu Asn Asn Phe Ala Leu 
            20                  25                  30          


Pro Ala Val Asn Cys Val Gly Thr Asp Ser Ile Asn Ala Val Leu Glu 
        35                  40                  45              


Thr Ala Ala Lys Val Lys Ala Pro Val Ile Val Gln Phe Ser Asn Gly 
    50                  55                  60                  


Gly Ala Ser Phe Ile Ala Gly Lys Gly Val Lys Ser Asp Val Pro Gln 
65                  70                  75                  80  


Gly Ala Ala Ile Leu Gly Ala Ile Ser Gly Ala His His Val His Gln 
                85                  90                  95      


Met Ala Glu His Tyr Gly Val Pro Val Ile Leu His Thr Asp His Cys 
            100                 105                 110         


Ala Lys Lys Leu Leu Pro Trp Ile Asp Gly Leu Leu Asp Ala Gly Glu 
        115                 120                 125             


Lys His Phe Ala Ala Thr Gly Lys Pro Leu Phe Ser Ser His Met Ile 
    130                 135                 140                 


Asp Leu Ser Glu Glu Ser Leu Gln Glu Asn Ile Glu Ile Cys Ser Lys 
145                 150                 155                 160 


Tyr Leu Glu Arg Met Ser Lys Ile Gly Met Thr Leu Glu Ile Glu Leu 
                165                 170                 175     


Gly Cys Thr Gly Gly Glu Glu Asp Gly Val Asp Asn Ser His Met Asp 
            180                 185                 190         


Ala Ser Ala Leu Tyr Thr Gln Pro Glu Asp Val Asp Tyr Ala Tyr Thr 
        195                 200                 205             


Glu Leu Ser Lys Ile Ser Pro Arg Phe Thr Ile Ala Ala Ser Phe Gly 
    210                 215                 220                 


Asn Val His Gly Val Tyr Lys Pro Gly Asn Val Val Leu Thr Pro Thr 
225                 230                 235                 240 


Ile Leu Arg Asp Ser Gln Glu Tyr Val Ser Lys Lys His Asn Leu Pro 
                245                 250                 255     


His Asn Ser Leu Asn Phe Val Phe His Gly Gly Ser Gly Ser Thr Ala 
            260                 265                 270         


Gln Glu Ile Lys Asp Ser Val Ser Tyr Gly Val Val Lys Met Asn Ile 
        275                 280                 285             


Asp Thr Asp Thr Gln Trp Ala Thr Trp Glu Gly Val Leu Asn Tyr Tyr 
    290                 295                 300                 


Lys Ala Asn Glu Ala Tyr Leu Gln Gly Gln Leu Gly Asn Pro Lys Gly 
305                 310                 315                 320 


Glu Asp Gln Pro Asn Lys Lys Tyr Tyr Asp Pro Arg Val Trp Leu Arg 
                325                 330                 335     


Ala Gly Gln Thr Ser Met Ile Ala Arg Leu Glu Lys Ala Phe Gln Glu 
            340                 345                 350         


Leu Asn Ala Ile Asp Val Leu 
        355                 


<210>  17
<211>  1185
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(1185)

<400>  17
atg aaa aat tgt gtc atc gtc agt gcg gta cgt act gct atc ggt agt         48
Met Lys Asn Cys Val Ile Val Ser Ala Val Arg Thr Ala Ile Gly Ser           
1               5                   10                  15                

ttt aac ggt tca ctc gct tcc acc agc gcc atc gac ctg ggg gcg aca         96
Phe Asn Gly Ser Leu Ala Ser Thr Ser Ala Ile Asp Leu Gly Ala Thr           
            20                  25                  30                    

gta att aaa gcc gcc att gaa cgt gca aaa atc gat tca caa cac gtt        144
Val Ile Lys Ala Ala Ile Glu Arg Ala Lys Ile Asp Ser Gln His Val           
        35                  40                  45                        

gat gaa gtg att atg ggt aac gtg tta caa gcc ggg ctg ggg caa aat        192
Asp Glu Val Ile Met Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn           
    50                  55                  60                            

ccg gcg cgt cag gca ctg tta aaa agc ggg ctg gca gaa acg gtg tgc        240
Pro Ala Arg Gln Ala Leu Leu Lys Ser Gly Leu Ala Glu Thr Val Cys           
65                  70                  75                  80            

gga ttc acg gtc aat aaa gta tgt ggt tcg ggt ctt aaa agt gtg gcg        288
Gly Phe Thr Val Asn Lys Val Cys Gly Ser Gly Leu Lys Ser Val Ala           
                85                  90                  95                

ctt gcc gcc cag gcc att cag gca ggt cag gcg cag agc att gtg gcg        336
Leu Ala Ala Gln Ala Ile Gln Ala Gly Gln Ala Gln Ser Ile Val Ala           
            100                 105                 110                   

ggg ggt atg gaa aat atg agt tta gcc ccc tac tta ctc gat gca aaa        384
Gly Gly Met Glu Asn Met Ser Leu Ala Pro Tyr Leu Leu Asp Ala Lys           
        115                 120                 125                       

gca cgc tct ggt tat cgt ctt gga gac gga cag gtt tat gac gta atc        432
Ala Arg Ser Gly Tyr Arg Leu Gly Asp Gly Gln Val Tyr Asp Val Ile           
    130                 135                 140                           

ctg cgc gat ggc ctg atg tgc gcc acc cat ggt tat cat atg ggg att        480
Leu Arg Asp Gly Leu Met Cys Ala Thr His Gly Tyr His Met Gly Ile           
145                 150                 155                 160           

acc gcc gaa aac gtg gct aaa gag tac gga att acc cgt gaa atg cag        528
Thr Ala Glu Asn Val Ala Lys Glu Tyr Gly Ile Thr Arg Glu Met Gln           
                165                 170                 175               

gat gaa ctg gcg cta cat tca cag cgt aaa gcg gca gcc gca att gag        576
Asp Glu Leu Ala Leu His Ser Gln Arg Lys Ala Ala Ala Ala Ile Glu           
            180                 185                 190                   

tcc ggt gct ttt aca gcc gaa atc gtc ccg gta aat gtt gtc act cga        624
Ser Gly Ala Phe Thr Ala Glu Ile Val Pro Val Asn Val Val Thr Arg           
        195                 200                 205                       

aag aaa acc ttc gtc ttc agt caa gac gaa ttc ccg aaa gcg aat tca        672
Lys Lys Thr Phe Val Phe Ser Gln Asp Glu Phe Pro Lys Ala Asn Ser           
    210                 215                 220                           

acg gct gaa gcg tta ggt gca ttg cgc ccg gcc ttc gat aaa gca gga        720
Thr Ala Glu Ala Leu Gly Ala Leu Arg Pro Ala Phe Asp Lys Ala Gly           
225                 230                 235                 240           

aca gtc acc gct ggg aac gcg tct ggt att aac gac ggt gct gcc gct        768
Thr Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Gly Ala Ala Ala           
                245                 250                 255               

ctg gtg att atg gaa gaa tct gcg gcg ctg gca gca ggc ctt acc ccc        816
Leu Val Ile Met Glu Glu Ser Ala Ala Leu Ala Ala Gly Leu Thr Pro           
            260                 265                 270                   

ctg gct cgc att aaa agt tat gcc agc ggt ggc gtg ccc ccc gca ttg        864
Leu Ala Arg Ile Lys Ser Tyr Ala Ser Gly Gly Val Pro Pro Ala Leu           
        275                 280                 285                       

atg ggt atg ggg cca gta cct gcc acg caa aaa gcg tta caa ctg gcg        912
Met Gly Met Gly Pro Val Pro Ala Thr Gln Lys Ala Leu Gln Leu Ala           
    290                 295                 300                           

ggg ctg caa ctg gcg gat att gat ctc att gag gct aat gaa gca ttt        960
Gly Leu Gln Leu Ala Asp Ile Asp Leu Ile Glu Ala Asn Glu Ala Phe           
305                 310                 315                 320           

gct gca cag ttc ctt gcc gtt ggg aaa aac ctg ggc ttt gat tct gag       1008
Ala Ala Gln Phe Leu Ala Val Gly Lys Asn Leu Gly Phe Asp Ser Glu           
                325                 330                 335               

aaa gtg aat gtc aac ggc ggg gcc atc gcg ctc ggg cat cct atc ggt       1056
Lys Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly           
            340                 345                 350                   

gcc agt ggt gct cgt att ctg gtc aca cta tta cat gcc atg cag gca       1104
Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu His Ala Met Gln Ala           
        355                 360                 365                       

cgc gat aaa acg ctg ggg ctg gca aca ctg tgc att ggc ggc ggt cag       1152
Arg Asp Lys Thr Leu Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln           
    370                 375                 380                           

gga att gcg atg gtg att gaa cgg ttg aat taa                           1185
Gly Ile Ala Met Val Ile Glu Arg Leu Asn                                   
385                 390                                                   


<210>  18
<211>  394
<212>  PRT
<213>  Escherichia coli

<400>  18

Met Lys Asn Cys Val Ile Val Ser Ala Val Arg Thr Ala Ile Gly Ser 
1               5                   10                  15      


Phe Asn Gly Ser Leu Ala Ser Thr Ser Ala Ile Asp Leu Gly Ala Thr 
            20                  25                  30          


Val Ile Lys Ala Ala Ile Glu Arg Ala Lys Ile Asp Ser Gln His Val 
        35                  40                  45              


Asp Glu Val Ile Met Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn 
    50                  55                  60                  


Pro Ala Arg Gln Ala Leu Leu Lys Ser Gly Leu Ala Glu Thr Val Cys 
65                  70                  75                  80  


Gly Phe Thr Val Asn Lys Val Cys Gly Ser Gly Leu Lys Ser Val Ala 
                85                  90                  95      


Leu Ala Ala Gln Ala Ile Gln Ala Gly Gln Ala Gln Ser Ile Val Ala 
            100                 105                 110         


Gly Gly Met Glu Asn Met Ser Leu Ala Pro Tyr Leu Leu Asp Ala Lys 
        115                 120                 125             


Ala Arg Ser Gly Tyr Arg Leu Gly Asp Gly Gln Val Tyr Asp Val Ile 
    130                 135                 140                 


Leu Arg Asp Gly Leu Met Cys Ala Thr His Gly Tyr His Met Gly Ile 
145                 150                 155                 160 


Thr Ala Glu Asn Val Ala Lys Glu Tyr Gly Ile Thr Arg Glu Met Gln 
                165                 170                 175     


Asp Glu Leu Ala Leu His Ser Gln Arg Lys Ala Ala Ala Ala Ile Glu 
            180                 185                 190         


Ser Gly Ala Phe Thr Ala Glu Ile Val Pro Val Asn Val Val Thr Arg 
        195                 200                 205             


Lys Lys Thr Phe Val Phe Ser Gln Asp Glu Phe Pro Lys Ala Asn Ser 
    210                 215                 220                 


Thr Ala Glu Ala Leu Gly Ala Leu Arg Pro Ala Phe Asp Lys Ala Gly 
225                 230                 235                 240 


Thr Val Thr Ala Gly Asn Ala Ser Gly Ile Asn Asp Gly Ala Ala Ala 
                245                 250                 255     


Leu Val Ile Met Glu Glu Ser Ala Ala Leu Ala Ala Gly Leu Thr Pro 
            260                 265                 270         


Leu Ala Arg Ile Lys Ser Tyr Ala Ser Gly Gly Val Pro Pro Ala Leu 
        275                 280                 285             


Met Gly Met Gly Pro Val Pro Ala Thr Gln Lys Ala Leu Gln Leu Ala 
    290                 295                 300                 


Gly Leu Gln Leu Ala Asp Ile Asp Leu Ile Glu Ala Asn Glu Ala Phe 
305                 310                 315                 320 


Ala Ala Gln Phe Leu Ala Val Gly Lys Asn Leu Gly Phe Asp Ser Glu 
                325                 330                 335     


Lys Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly 
            340                 345                 350         


Ala Ser Gly Ala Arg Ile Leu Val Thr Leu Leu His Ala Met Gln Ala 
        355                 360                 365             


Arg Asp Lys Thr Leu Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln 
    370                 375                 380                 


Gly Ile Ala Met Val Ile Glu Arg Leu Asn 
385                 390                 


<210>  19
<211>  1179
<212>  DNA
<213>  Clostridium acetobutylicum


<220>
<221>  CDS
<222>  (1)..(1179)

<400>  19
atg aaa gaa gtt gta ata gct agt gca gta aga aca gcg att gga tct         48
Met Lys Glu Val Val Ile Ala Ser Ala Val Arg Thr Ala Ile Gly Ser           
1               5                   10                  15                

tat gga aag tct ctt aag gat gta cca gca gta gat tta gga gct aca         96
Tyr Gly Lys Ser Leu Lys Asp Val Pro Ala Val Asp Leu Gly Ala Thr           
            20                  25                  30                    

gct ata aag gaa gca gtt aaa aaa gca gga ata aaa cca gag gat gtt        144
Ala Ile Lys Glu Ala Val Lys Lys Ala Gly Ile Lys Pro Glu Asp Val           
        35                  40                  45                        

aat gaa gtc att tta gga aat gtt ctt caa gca ggt tta gga cag aat        192
Asn Glu Val Ile Leu Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn           
    50                  55                  60                            

cca gca aga cag gca tct ttt aaa gca gga tta cca gtt gaa att cca        240
Pro Ala Arg Gln Ala Ser Phe Lys Ala Gly Leu Pro Val Glu Ile Pro           
65                  70                  75                  80            

gct atg act att aat aag gtt tgt ggt tca gga ctt aga aca gtt agc        288
Ala Met Thr Ile Asn Lys Val Cys Gly Ser Gly Leu Arg Thr Val Ser           
                85                  90                  95                

tta gca gca caa att ata aaa gca gga gat gct gac gta ata ata gca        336
Leu Ala Ala Gln Ile Ile Lys Ala Gly Asp Ala Asp Val Ile Ile Ala           
            100                 105                 110                   

ggt ggt atg gaa aat atg tct aga gct cct tac tta gcg aat aac gct        384
Gly Gly Met Glu Asn Met Ser Arg Ala Pro Tyr Leu Ala Asn Asn Ala           
        115                 120                 125                       

aga tgg gga tat aga atg gga aac gct aaa ttt gtt gat gaa atg atc        432
Arg Trp Gly Tyr Arg Met Gly Asn Ala Lys Phe Val Asp Glu Met Ile           
    130                 135                 140                           

act gac gga ttg tgg gat gca ttt aat gat tac cac atg gga ata aca        480
Thr Asp Gly Leu Trp Asp Ala Phe Asn Asp Tyr His Met Gly Ile Thr           
145                 150                 155                 160           

gca gaa aac ata gct gag aga tgg aac att tca aga gaa gaa caa gat        528
Ala Glu Asn Ile Ala Glu Arg Trp Asn Ile Ser Arg Glu Glu Gln Asp           
                165                 170                 175               

gag ttt gct ctt gca tca caa aaa aaa gct gaa gaa gct ata aaa tca        576
Glu Phe Ala Leu Ala Ser Gln Lys Lys Ala Glu Glu Ala Ile Lys Ser           
            180                 185                 190                   

ggt caa ttt aaa gat gaa ata gtt cct gta gta att aaa ggc aga aag        624
Gly Gln Phe Lys Asp Glu Ile Val Pro Val Val Ile Lys Gly Arg Lys           
        195                 200                 205                       

gga gaa act gta gtt gat aca gat gag cac cct aga ttt gga tca act        672
Gly Glu Thr Val Val Asp Thr Asp Glu His Pro Arg Phe Gly Ser Thr           
    210                 215                 220                           

ata gaa gga ctt gca aaa tta aaa cct gcc ttc aaa aaa gat gga aca        720
Ile Glu Gly Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Thr           
225                 230                 235                 240           

gtt aca gct ggt aat gca tca gga tta aat gac tgt gca gca gta ctt        768
Val Thr Ala Gly Asn Ala Ser Gly Leu Asn Asp Cys Ala Ala Val Leu           
                245                 250                 255               

gta atc atg agt gca gaa aaa gct aaa gag ctt gga gta aaa cca ctt        816
Val Ile Met Ser Ala Glu Lys Ala Lys Glu Leu Gly Val Lys Pro Leu           
            260                 265                 270                   

gct aag ata gtt tct tat ggt tca gca gga gtt gac cca gca ata atg        864
Ala Lys Ile Val Ser Tyr Gly Ser Ala Gly Val Asp Pro Ala Ile Met           
        275                 280                 285                       

gga tat gga cct ttc tat gca aca aaa gca gct att gaa aaa gca ggt        912
Gly Tyr Gly Pro Phe Tyr Ala Thr Lys Ala Ala Ile Glu Lys Ala Gly           
    290                 295                 300                           

tgg aca gtt gat gaa tta gat tta ata gaa tca aat gaa gct ttt gca        960
Trp Thr Val Asp Glu Leu Asp Leu Ile Glu Ser Asn Glu Ala Phe Ala           
305                 310                 315                 320           

gct caa agt tta gca gta gca aaa gat tta aaa ttt gat atg aat aaa       1008
Ala Gln Ser Leu Ala Val Ala Lys Asp Leu Lys Phe Asp Met Asn Lys           
                325                 330                 335               

gta aat gta aat gga gga gct att gcc ctt ggt cat cca att gga gca       1056
Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly Ala           
            340                 345                 350                   

tca ggt gca aga ata ctc gtt act ctt gta cac gca atg caa aaa aga       1104
Ser Gly Ala Arg Ile Leu Val Thr Leu Val His Ala Met Gln Lys Arg           
        355                 360                 365                       

gat gca aaa aaa ggc tta gca act tta tgt ata ggt ggc gga caa gga       1152
Asp Ala Lys Lys Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln Gly           
    370                 375                 380                           

aca gca ata ttg cta gaa aag tgc tag                                   1179
Thr Ala Ile Leu Leu Glu Lys Cys                                           
385                 390                                                   


<210>  20
<211>  392
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  20

Met Lys Glu Val Val Ile Ala Ser Ala Val Arg Thr Ala Ile Gly Ser 
1               5                   10                  15      


Tyr Gly Lys Ser Leu Lys Asp Val Pro Ala Val Asp Leu Gly Ala Thr 
            20                  25                  30          


Ala Ile Lys Glu Ala Val Lys Lys Ala Gly Ile Lys Pro Glu Asp Val 
        35                  40                  45              


Asn Glu Val Ile Leu Gly Asn Val Leu Gln Ala Gly Leu Gly Gln Asn 
    50                  55                  60                  


Pro Ala Arg Gln Ala Ser Phe Lys Ala Gly Leu Pro Val Glu Ile Pro 
65                  70                  75                  80  


Ala Met Thr Ile Asn Lys Val Cys Gly Ser Gly Leu Arg Thr Val Ser 
                85                  90                  95      


Leu Ala Ala Gln Ile Ile Lys Ala Gly Asp Ala Asp Val Ile Ile Ala 
            100                 105                 110         


Gly Gly Met Glu Asn Met Ser Arg Ala Pro Tyr Leu Ala Asn Asn Ala 
        115                 120                 125             


Arg Trp Gly Tyr Arg Met Gly Asn Ala Lys Phe Val Asp Glu Met Ile 
    130                 135                 140                 


Thr Asp Gly Leu Trp Asp Ala Phe Asn Asp Tyr His Met Gly Ile Thr 
145                 150                 155                 160 


Ala Glu Asn Ile Ala Glu Arg Trp Asn Ile Ser Arg Glu Glu Gln Asp 
                165                 170                 175     


Glu Phe Ala Leu Ala Ser Gln Lys Lys Ala Glu Glu Ala Ile Lys Ser 
            180                 185                 190         


Gly Gln Phe Lys Asp Glu Ile Val Pro Val Val Ile Lys Gly Arg Lys 
        195                 200                 205             


Gly Glu Thr Val Val Asp Thr Asp Glu His Pro Arg Phe Gly Ser Thr 
    210                 215                 220                 


Ile Glu Gly Leu Ala Lys Leu Lys Pro Ala Phe Lys Lys Asp Gly Thr 
225                 230                 235                 240 


Val Thr Ala Gly Asn Ala Ser Gly Leu Asn Asp Cys Ala Ala Val Leu 
                245                 250                 255     


Val Ile Met Ser Ala Glu Lys Ala Lys Glu Leu Gly Val Lys Pro Leu 
            260                 265                 270         


Ala Lys Ile Val Ser Tyr Gly Ser Ala Gly Val Asp Pro Ala Ile Met 
        275                 280                 285             


Gly Tyr Gly Pro Phe Tyr Ala Thr Lys Ala Ala Ile Glu Lys Ala Gly 
    290                 295                 300                 


Trp Thr Val Asp Glu Leu Asp Leu Ile Glu Ser Asn Glu Ala Phe Ala 
305                 310                 315                 320 


Ala Gln Ser Leu Ala Val Ala Lys Asp Leu Lys Phe Asp Met Asn Lys 
                325                 330                 335     


Val Asn Val Asn Gly Gly Ala Ile Ala Leu Gly His Pro Ile Gly Ala 
            340                 345                 350         


Ser Gly Ala Arg Ile Leu Val Thr Leu Val His Ala Met Gln Lys Arg 
        355                 360                 365             


Asp Ala Lys Lys Gly Leu Ala Thr Leu Cys Ile Gly Gly Gly Gln Gly 
    370                 375                 380                 


Thr Ala Ile Leu Leu Glu Lys Cys 
385                 390         


<210>  21
<211>  849
<212>  DNA
<213>  Clostridium acetobutylicum


<220>
<221>  CDS
<222>  (1)..(849)

<400>  21
atg aaa aag gta tgt gtt ata ggt gca ggt act atg ggt tca gga att         48
Met Lys Lys Val Cys Val Ile Gly Ala Gly Thr Met Gly Ser Gly Ile           
1               5                   10                  15                

gct cag gca ttt gca gct aaa gga ttt gaa gta gta tta aga gat att         96
Ala Gln Ala Phe Ala Ala Lys Gly Phe Glu Val Val Leu Arg Asp Ile           
            20                  25                  30                    

aaa gat gaa ttt gtt gat aga gga tta gat ttt atc aat aaa aat ctt        144
Lys Asp Glu Phe Val Asp Arg Gly Leu Asp Phe Ile Asn Lys Asn Leu           
        35                  40                  45                        

tct aaa tta gtt aaa aaa gga aag ata gaa gaa gct act aaa gtt gaa        192
Ser Lys Leu Val Lys Lys Gly Lys Ile Glu Glu Ala Thr Lys Val Glu           
    50                  55                  60                            

atc tta act aga att tcc gga aca gtt gac ctt aat atg gca gct gat        240
Ile Leu Thr Arg Ile Ser Gly Thr Val Asp Leu Asn Met Ala Ala Asp           
65                  70                  75                  80            

tgc gat tta gtt ata gaa gca gct gtt gaa aga atg gat att aaa aag        288
Cys Asp Leu Val Ile Glu Ala Ala Val Glu Arg Met Asp Ile Lys Lys           
                85                  90                  95                

cag att ttt gct gac tta gac aat ata tgc aag cca gaa aca att ctt        336
Gln Ile Phe Ala Asp Leu Asp Asn Ile Cys Lys Pro Glu Thr Ile Leu           
            100                 105                 110                   

gca tca aat aca tca tca ctt tca ata aca gaa gtg gca tca gca act        384
Ala Ser Asn Thr Ser Ser Leu Ser Ile Thr Glu Val Ala Ser Ala Thr           
        115                 120                 125                       

aaa aga cct gat aag gtt ata ggt atg cat ttc ttt aat cca gct cct        432
Lys Arg Pro Asp Lys Val Ile Gly Met His Phe Phe Asn Pro Ala Pro           
    130                 135                 140                           

gtt atg aag ctt gta gag gta ata aga gga ata gct aca tca caa gaa        480
Val Met Lys Leu Val Glu Val Ile Arg Gly Ile Ala Thr Ser Gln Glu           
145                 150                 155                 160           

act ttt gat gca gtt aaa gag aca tct ata gca ata gga aaa gat cct        528
Thr Phe Asp Ala Val Lys Glu Thr Ser Ile Ala Ile Gly Lys Asp Pro           
                165                 170                 175               

gta gaa gta gca gaa gca cca gga ttt gtt gta aat aga ata tta ata        576
Val Glu Val Ala Glu Ala Pro Gly Phe Val Val Asn Arg Ile Leu Ile           
            180                 185                 190                   

cca atg att aat gaa gca gtt ggt ata tta gca gaa gga ata gct tca        624
Pro Met Ile Asn Glu Ala Val Gly Ile Leu Ala Glu Gly Ile Ala Ser           
        195                 200                 205                       

gta gaa gac ata gat aaa gct atg aaa ctt gga gct aat cac cca atg        672
Val Glu Asp Ile Asp Lys Ala Met Lys Leu Gly Ala Asn His Pro Met           
    210                 215                 220                           

gga cca tta gaa tta ggt gat ttt ata ggt ctt gat ata tgt ctt gct        720
Gly Pro Leu Glu Leu Gly Asp Phe Ile Gly Leu Asp Ile Cys Leu Ala           
225                 230                 235                 240           

ata atg gat gtt tta tac tca gaa act gga gat tct aag tat aga cca        768
Ile Met Asp Val Leu Tyr Ser Glu Thr Gly Asp Ser Lys Tyr Arg Pro           
                245                 250                 255               

cat aca tta ctt aag aag tat gta aga gca gga tgg ctt gga aga aaa        816
His Thr Leu Leu Lys Lys Tyr Val Arg Ala Gly Trp Leu Gly Arg Lys           
            260                 265                 270                   

tca gga aaa ggt ttc tac gat tat tca aaa taa                            849
Ser Gly Lys Gly Phe Tyr Asp Tyr Ser Lys                                   
        275                 280                                           


<210>  22
<211>  282
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  22

Met Lys Lys Val Cys Val Ile Gly Ala Gly Thr Met Gly Ser Gly Ile 
1               5                   10                  15      


Ala Gln Ala Phe Ala Ala Lys Gly Phe Glu Val Val Leu Arg Asp Ile 
            20                  25                  30          


Lys Asp Glu Phe Val Asp Arg Gly Leu Asp Phe Ile Asn Lys Asn Leu 
        35                  40                  45              


Ser Lys Leu Val Lys Lys Gly Lys Ile Glu Glu Ala Thr Lys Val Glu 
    50                  55                  60                  


Ile Leu Thr Arg Ile Ser Gly Thr Val Asp Leu Asn Met Ala Ala Asp 
65                  70                  75                  80  


Cys Asp Leu Val Ile Glu Ala Ala Val Glu Arg Met Asp Ile Lys Lys 
                85                  90                  95      


Gln Ile Phe Ala Asp Leu Asp Asn Ile Cys Lys Pro Glu Thr Ile Leu 
            100                 105                 110         


Ala Ser Asn Thr Ser Ser Leu Ser Ile Thr Glu Val Ala Ser Ala Thr 
        115                 120                 125             


Lys Arg Pro Asp Lys Val Ile Gly Met His Phe Phe Asn Pro Ala Pro 
    130                 135                 140                 


Val Met Lys Leu Val Glu Val Ile Arg Gly Ile Ala Thr Ser Gln Glu 
145                 150                 155                 160 


Thr Phe Asp Ala Val Lys Glu Thr Ser Ile Ala Ile Gly Lys Asp Pro 
                165                 170                 175     


Val Glu Val Ala Glu Ala Pro Gly Phe Val Val Asn Arg Ile Leu Ile 
            180                 185                 190         


Pro Met Ile Asn Glu Ala Val Gly Ile Leu Ala Glu Gly Ile Ala Ser 
        195                 200                 205             


Val Glu Asp Ile Asp Lys Ala Met Lys Leu Gly Ala Asn His Pro Met 
    210                 215                 220                 


Gly Pro Leu Glu Leu Gly Asp Phe Ile Gly Leu Asp Ile Cys Leu Ala 
225                 230                 235                 240 


Ile Met Asp Val Leu Tyr Ser Glu Thr Gly Asp Ser Lys Tyr Arg Pro 
                245                 250                 255     


His Thr Leu Leu Lys Lys Tyr Val Arg Ala Gly Trp Leu Gly Arg Lys 
            260                 265                 270         


Ser Gly Lys Gly Phe Tyr Asp Tyr Ser Lys 
        275                 280         


<210>  23
<211>  786
<212>  DNA
<213>  Clostridium acetobutylicum


<220>
<221>  CDS
<222>  (1)..(786)

<400>  23
atg gaa cta aac aat gtc atc ctt gaa aag gaa ggt aaa gtt gct gta         48
Met Glu Leu Asn Asn Val Ile Leu Glu Lys Glu Gly Lys Val Ala Val           
1               5                   10                  15                

gtt acc att aac aga cct aaa gca tta aat gcg tta aat agt gat aca         96
Val Thr Ile Asn Arg Pro Lys Ala Leu Asn Ala Leu Asn Ser Asp Thr           
            20                  25                  30                    

cta aaa gaa atg gat tat gtt ata ggt gaa att gaa aat gat agc gaa        144
Leu Lys Glu Met Asp Tyr Val Ile Gly Glu Ile Glu Asn Asp Ser Glu           
        35                  40                  45                        

gta ctt gca gta att tta act gga gca gga gaa aaa tca ttt gta gca        192
Val Leu Ala Val Ile Leu Thr Gly Ala Gly Glu Lys Ser Phe Val Ala           
    50                  55                  60                            

gga gca gat att tct gag atg aag gaa atg aat acc att gaa ggt aga        240
Gly Ala Asp Ile Ser Glu Met Lys Glu Met Asn Thr Ile Glu Gly Arg           
65                  70                  75                  80            

aaa ttc ggg ata ctt gga aat aaa gtg ttt aga aga tta gaa ctt ctt        288
Lys Phe Gly Ile Leu Gly Asn Lys Val Phe Arg Arg Leu Glu Leu Leu           
                85                  90                  95                

gaa aag cct gta ata gca gct gtt aat ggt ttt gct tta gga ggc gga        336
Glu Lys Pro Val Ile Ala Ala Val Asn Gly Phe Ala Leu Gly Gly Gly           
            100                 105                 110                   

tgc gaa ata gct atg tct tgt gat ata aga ata gct tca agc aac gca        384
Cys Glu Ile Ala Met Ser Cys Asp Ile Arg Ile Ala Ser Ser Asn Ala           
        115                 120                 125                       

aga ttt ggt caa cca gaa gta ggt ctc gga ata aca cct ggt ttt ggt        432
Arg Phe Gly Gln Pro Glu Val Gly Leu Gly Ile Thr Pro Gly Phe Gly           
    130                 135                 140                           

ggt aca caa aga ctt tca aga tta gtt gga atg ggc atg gca aag cag        480
Gly Thr Gln Arg Leu Ser Arg Leu Val Gly Met Gly Met Ala Lys Gln           
145                 150                 155                 160           

ctt ata ttt act gca caa aat ata aag gca gat gaa gca tta aga atc        528
Leu Ile Phe Thr Ala Gln Asn Ile Lys Ala Asp Glu Ala Leu Arg Ile           
                165                 170                 175               

gga ctt gta aat aag gta gta gaa cct agt gaa tta atg aat aca gca        576
Gly Leu Val Asn Lys Val Val Glu Pro Ser Glu Leu Met Asn Thr Ala           
            180                 185                 190                   

aaa gaa att gca aac aaa att gtg agc aat gct cca gta gct gtt aag        624
Lys Glu Ile Ala Asn Lys Ile Val Ser Asn Ala Pro Val Ala Val Lys           
        195                 200                 205                       

tta agc aaa cag gct att aat aga gga atg cag tgt gat att gat act        672
Leu Ser Lys Gln Ala Ile Asn Arg Gly Met Gln Cys Asp Ile Asp Thr           
    210                 215                 220                           

gct tta gca ttt gaa tca gaa gca ttt gga gaa tgc ttt tca aca gag        720
Ala Leu Ala Phe Glu Ser Glu Ala Phe Gly Glu Cys Phe Ser Thr Glu           
225                 230                 235                 240           

gat caa aag gat gca atg aca gct ttc ata gag aaa aga aaa att gaa        768
Asp Gln Lys Asp Ala Met Thr Ala Phe Ile Glu Lys Arg Lys Ile Glu           
                245                 250                 255               

ggc ttc aaa aat aga tag                                                786
Gly Phe Lys Asn Arg                                                       
            260                                                           


<210>  24
<211>  261
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  24

Met Glu Leu Asn Asn Val Ile Leu Glu Lys Glu Gly Lys Val Ala Val 
1               5                   10                  15      


Val Thr Ile Asn Arg Pro Lys Ala Leu Asn Ala Leu Asn Ser Asp Thr 
            20                  25                  30          


Leu Lys Glu Met Asp Tyr Val Ile Gly Glu Ile Glu Asn Asp Ser Glu 
        35                  40                  45              


Val Leu Ala Val Ile Leu Thr Gly Ala Gly Glu Lys Ser Phe Val Ala 
    50                  55                  60                  


Gly Ala Asp Ile Ser Glu Met Lys Glu Met Asn Thr Ile Glu Gly Arg 
65                  70                  75                  80  


Lys Phe Gly Ile Leu Gly Asn Lys Val Phe Arg Arg Leu Glu Leu Leu 
                85                  90                  95      


Glu Lys Pro Val Ile Ala Ala Val Asn Gly Phe Ala Leu Gly Gly Gly 
            100                 105                 110         


Cys Glu Ile Ala Met Ser Cys Asp Ile Arg Ile Ala Ser Ser Asn Ala 
        115                 120                 125             


Arg Phe Gly Gln Pro Glu Val Gly Leu Gly Ile Thr Pro Gly Phe Gly 
    130                 135                 140                 


Gly Thr Gln Arg Leu Ser Arg Leu Val Gly Met Gly Met Ala Lys Gln 
145                 150                 155                 160 


Leu Ile Phe Thr Ala Gln Asn Ile Lys Ala Asp Glu Ala Leu Arg Ile 
                165                 170                 175     


Gly Leu Val Asn Lys Val Val Glu Pro Ser Glu Leu Met Asn Thr Ala 
            180                 185                 190         


Lys Glu Ile Ala Asn Lys Ile Val Ser Asn Ala Pro Val Ala Val Lys 
        195                 200                 205             


Leu Ser Lys Gln Ala Ile Asn Arg Gly Met Gln Cys Asp Ile Asp Thr 
    210                 215                 220                 


Ala Leu Ala Phe Glu Ser Glu Ala Phe Gly Glu Cys Phe Ser Thr Glu 
225                 230                 235                 240 


Asp Gln Lys Asp Ala Met Thr Ala Phe Ile Glu Lys Arg Lys Ile Glu 
                245                 250                 255     


Gly Phe Lys Asn Arg 
            260     


<210>  25
<211>  1344
<212>  DNA
<213>  Streptomyces coelicolor


<220>
<221>  CDS
<222>  (1)..(1344)

<400>  25
gtg acc gtg aag gac atc ctg gac gcg atc cag tcg ccc gac tcc acg         48
Val Thr Val Lys Asp Ile Leu Asp Ala Ile Gln Ser Pro Asp Ser Thr           
1               5                   10                  15                

ccg gcc gac atc gcc gca ctg ccg ctc ccc gag tcg tac cgc gcg atc         96
Pro Ala Asp Ile Ala Ala Leu Pro Leu Pro Glu Ser Tyr Arg Ala Ile           
            20                  25                  30                    

acc gtg cac aag gac gag acc gag atg ttc gcg ggc ctc gag acc cgc        144
Thr Val His Lys Asp Glu Thr Glu Met Phe Ala Gly Leu Glu Thr Arg           
        35                  40                  45                        

gac aag gac ccc cgc aag tcg atc cac ctg gac gac gtg ccg gtg ccc        192
Asp Lys Asp Pro Arg Lys Ser Ile His Leu Asp Asp Val Pro Val Pro           
    50                  55                  60                            

gag ctg ggc ccc ggc gag gcc ctg gtg gcc gtc atg gcc tcc tcg gtc        240
Glu Leu Gly Pro Gly Glu Ala Leu Val Ala Val Met Ala Ser Ser Val           
65                  70                  75                  80            

aac tac aac tcg gtg tgg acc tcg atc ttc gag ccg ctg tcc acc ttc        288
Asn Tyr Asn Ser Val Trp Thr Ser Ile Phe Glu Pro Leu Ser Thr Phe           
                85                  90                  95                

ggg ttc ctg gag cgc tac ggc cgg gtc agc gac ctc gcc aag cgg cac        336
Gly Phe Leu Glu Arg Tyr Gly Arg Val Ser Asp Leu Ala Lys Arg His           
            100                 105                 110                   

gac ctg ccg tac cac gtc atc ggc tcc gac ctc gcc ggt gtc gtc ctg        384
Asp Leu Pro Tyr His Val Ile Gly Ser Asp Leu Ala Gly Val Val Leu           
        115                 120                 125                       

cgc acc ggt ccg ggc gtc aac gcc tgg cag gcg ggc gac gag gtc gtc        432
Arg Thr Gly Pro Gly Val Asn Ala Trp Gln Ala Gly Asp Glu Val Val           
    130                 135                 140                           

gcg cac tgc ctc tcc gtc gag ctg gag tcc tcc gac ggc cac aac gac        480
Ala His Cys Leu Ser Val Glu Leu Glu Ser Ser Asp Gly His Asn Asp           
145                 150                 155                 160           

acg atg ctc gac ccc gag cag cgc atc tgg ggc ttc gag acc aac ttc        528
Thr Met Leu Asp Pro Glu Gln Arg Ile Trp Gly Phe Glu Thr Asn Phe           
                165                 170                 175               

ggc ggc ctc gcg gag atc gcg ctg gtc aag tcc aac cag ctg atg ccg        576
Gly Gly Leu Ala Glu Ile Ala Leu Val Lys Ser Asn Gln Leu Met Pro           
            180                 185                 190                   

aag ccg gac cac ctg agc tgg gag gag gcc gcc gct ccc ggc ctg gtc        624
Lys Pro Asp His Leu Ser Trp Glu Glu Ala Ala Ala Pro Gly Leu Val           
        195                 200                 205                       

aac tcc acc gcg tac cgc cag ctc gtc tcc cgc aac ggc gcc ggc atg        672
Asn Ser Thr Ala Tyr Arg Gln Leu Val Ser Arg Asn Gly Ala Gly Met           
    210                 215                 220                           

aag cag ggc gac aac gtg ctc atc tgg ggc gcg agc ggc gga ctc ggc        720
Lys Gln Gly Asp Asn Val Leu Ile Trp Gly Ala Ser Gly Gly Leu Gly           
225                 230                 235                 240           

tcg tac gcc acc cag ttc gcc ctc gcc ggc ggc gcc aac ccg atc tgc        768
Ser Tyr Ala Thr Gln Phe Ala Leu Ala Gly Gly Ala Asn Pro Ile Cys           
                245                 250                 255               

gtc gtc tcc tcg ccg cag aag gcg gag atc tgc cgc gcg atg ggc gcc        816
Val Val Ser Ser Pro Gln Lys Ala Glu Ile Cys Arg Ala Met Gly Ala           
            260                 265                 270                   

gag gcg atc atc gac cgc aac gcc gag ggc tac cgg ttc tgg aag gac        864
Glu Ala Ile Ile Asp Arg Asn Ala Glu Gly Tyr Arg Phe Trp Lys Asp           
        275                 280                 285                       

gag aac acc cag gac ccg aag gag tgg aag cgc ttc ggc aag cgc atc        912
Glu Asn Thr Gln Asp Pro Lys Glu Trp Lys Arg Phe Gly Lys Arg Ile           
    290                 295                 300                           

cgc gaa ctg acc ggc ggc gag gac atc gac atc gtc ttc gag cac ccc        960
Arg Glu Leu Thr Gly Gly Glu Asp Ile Asp Ile Val Phe Glu His Pro           
305                 310                 315                 320           

ggc cgc gag acc ttc ggc gcc tcc gtc ttc gtc acc cgc aag ggc ggc       1008
Gly Arg Glu Thr Phe Gly Ala Ser Val Phe Val Thr Arg Lys Gly Gly           
                325                 330                 335               

acc atc acc acc tgc gcc tcg acc tcg ggc tac atg cac gag tac gac       1056
Thr Ile Thr Thr Cys Ala Ser Thr Ser Gly Tyr Met His Glu Tyr Asp           
            340                 345                 350                   

aac cgc tac ctg tgg atg tcc ctg aag cgc atc atc ggc tcg cac ttc       1104
Asn Arg Tyr Leu Trp Met Ser Leu Lys Arg Ile Ile Gly Ser His Phe           
        355                 360                 365                       

gcc aac tac cgc gag gcc tgg gag gcc aac cgc ctc atc gcc aag ggc       1152
Ala Asn Tyr Arg Glu Ala Trp Glu Ala Asn Arg Leu Ile Ala Lys Gly           
    370                 375                 380                           

agg atc cac ccc acg ctc tcc aag gtg tac tcc ctc gag gac acc ggc       1200
Arg Ile His Pro Thr Leu Ser Lys Val Tyr Ser Leu Glu Asp Thr Gly           
385                 390                 395                 400           

cag gcc gcc tac gac gtc cac cgc aac ctc cac cag ggc aag gtc ggc       1248
Gln Ala Ala Tyr Asp Val His Arg Asn Leu His Gln Gly Lys Val Gly           
                405                 410                 415               

gtg ctg tgc ctg gcg ccc gag gag ggc ctg ggc gtg cgc gac cgg gag       1296
Val Leu Cys Leu Ala Pro Glu Glu Gly Leu Gly Val Arg Asp Arg Glu           
            420                 425                 430                   

aag cgc gcg cag cac ctc gac gcc atc aac cgc ttc cgg aac atc tga       1344
Lys Arg Ala Gln His Leu Asp Ala Ile Asn Arg Phe Arg Asn Ile               
        435                 440                 445                       


<210>  26
<211>  447
<212>  PRT
<213>  Streptomyces coelicolor

<400>  26

Val Thr Val Lys Asp Ile Leu Asp Ala Ile Gln Ser Pro Asp Ser Thr 
1               5                   10                  15      


Pro Ala Asp Ile Ala Ala Leu Pro Leu Pro Glu Ser Tyr Arg Ala Ile 
            20                  25                  30          


Thr Val His Lys Asp Glu Thr Glu Met Phe Ala Gly Leu Glu Thr Arg 
        35                  40                  45              


Asp Lys Asp Pro Arg Lys Ser Ile His Leu Asp Asp Val Pro Val Pro 
    50                  55                  60                  


Glu Leu Gly Pro Gly Glu Ala Leu Val Ala Val Met Ala Ser Ser Val 
65                  70                  75                  80  


Asn Tyr Asn Ser Val Trp Thr Ser Ile Phe Glu Pro Leu Ser Thr Phe 
                85                  90                  95      


Gly Phe Leu Glu Arg Tyr Gly Arg Val Ser Asp Leu Ala Lys Arg His 
            100                 105                 110         


Asp Leu Pro Tyr His Val Ile Gly Ser Asp Leu Ala Gly Val Val Leu 
        115                 120                 125             


Arg Thr Gly Pro Gly Val Asn Ala Trp Gln Ala Gly Asp Glu Val Val 
    130                 135                 140                 


Ala His Cys Leu Ser Val Glu Leu Glu Ser Ser Asp Gly His Asn Asp 
145                 150                 155                 160 


Thr Met Leu Asp Pro Glu Gln Arg Ile Trp Gly Phe Glu Thr Asn Phe 
                165                 170                 175     


Gly Gly Leu Ala Glu Ile Ala Leu Val Lys Ser Asn Gln Leu Met Pro 
            180                 185                 190         


Lys Pro Asp His Leu Ser Trp Glu Glu Ala Ala Ala Pro Gly Leu Val 
        195                 200                 205             


Asn Ser Thr Ala Tyr Arg Gln Leu Val Ser Arg Asn Gly Ala Gly Met 
    210                 215                 220                 


Lys Gln Gly Asp Asn Val Leu Ile Trp Gly Ala Ser Gly Gly Leu Gly 
225                 230                 235                 240 


Ser Tyr Ala Thr Gln Phe Ala Leu Ala Gly Gly Ala Asn Pro Ile Cys 
                245                 250                 255     


Val Val Ser Ser Pro Gln Lys Ala Glu Ile Cys Arg Ala Met Gly Ala 
            260                 265                 270         


Glu Ala Ile Ile Asp Arg Asn Ala Glu Gly Tyr Arg Phe Trp Lys Asp 
        275                 280                 285             


Glu Asn Thr Gln Asp Pro Lys Glu Trp Lys Arg Phe Gly Lys Arg Ile 
    290                 295                 300                 


Arg Glu Leu Thr Gly Gly Glu Asp Ile Asp Ile Val Phe Glu His Pro 
305                 310                 315                 320 


Gly Arg Glu Thr Phe Gly Ala Ser Val Phe Val Thr Arg Lys Gly Gly 
                325                 330                 335     


Thr Ile Thr Thr Cys Ala Ser Thr Ser Gly Tyr Met His Glu Tyr Asp 
            340                 345                 350         


Asn Arg Tyr Leu Trp Met Ser Leu Lys Arg Ile Ile Gly Ser His Phe 
        355                 360                 365             


Ala Asn Tyr Arg Glu Ala Trp Glu Ala Asn Arg Leu Ile Ala Lys Gly 
    370                 375                 380                 


Arg Ile His Pro Thr Leu Ser Lys Val Tyr Ser Leu Glu Asp Thr Gly 
385                 390                 395                 400 


Gln Ala Ala Tyr Asp Val His Arg Asn Leu His Gln Gly Lys Val Gly 
                405                 410                 415     


Val Leu Cys Leu Ala Pro Glu Glu Gly Leu Gly Val Arg Asp Arg Glu 
            420                 425                 430         


Lys Arg Ala Gln His Leu Asp Ala Ile Asn Arg Phe Arg Asn Ile 
        435                 440                 445         


<210>  27
<211>  398
<212>  PRT
<213>  Treponema dentricola


<220>
<221>  misc_feature
<222>  (398)..(398)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Met Ile Val Lys Pro Met Val Arg Asn Asn Ile Cys Leu Asn Ala His 
1               5                   10                  15      


Pro Gln Gly Cys Lys Lys Gly Val Glu Asp Gln Ile Glu Tyr Thr Lys 
            20                  25                  30          


Lys Arg Ile Thr Ala Glu Val Lys Ala Gly Ala Lys Ala Pro Lys Asn 
        35                  40                  45              


Val Leu Val Leu Gly Cys Ser Asn Gly Tyr Gly Leu Ala Ser Arg Ile 
    50                  55                  60                  


Thr Ala Ala Phe Gly Tyr Gly Ala Ala Thr Ile Gly Val Ser Phe Glu 
65                  70                  75                  80  


Lys Ala Gly Ser Glu Thr Lys Tyr Gly Thr Pro Gly Trp Tyr Asn Asn 
                85                  90                  95      


Leu Ala Phe Asp Glu Ala Ala Lys Arg Glu Gly Leu Tyr Ser Val Thr 
            100                 105                 110         


Ile Asp Gly Asp Ala Phe Ser Asp Glu Ile Lys Ala Gln Val Ile Glu 
        115                 120                 125             


Glu Ala Lys Lys Lys Gly Ile Lys Phe Asp Leu Ile Val Tyr Ser Leu 
    130                 135                 140                 


Ala Ser Pro Val Arg Thr Asp Pro Asp Thr Gly Ile Met His Lys Ser 
145                 150                 155                 160 


Val Leu Lys Pro Phe Gly Lys Thr Phe Thr Gly Lys Thr Val Asp Pro 
                165                 170                 175     


Phe Thr Gly Glu Leu Lys Glu Ile Ser Ala Glu Pro Ala Asn Asp Glu 
            180                 185                 190         


Glu Ala Ala Ala Thr Val Lys Val Met Gly Gly Glu Asp Trp Glu Arg 
        195                 200                 205             


Trp Ile Lys Gln Leu Ser Lys Glu Gly Leu Leu Glu Glu Gly Cys Ile 
    210                 215                 220                 


Thr Leu Ala Tyr Ser Tyr Ile Gly Pro Glu Ala Thr Gln Ala Leu Tyr 
225                 230                 235                 240 


Arg Lys Gly Thr Ile Gly Lys Ala Lys Glu His Leu Glu Ala Thr Ala 
                245                 250                 255     


His Arg Leu Asn Lys Glu Asn Pro Ser Ile Arg Ala Phe Val Ser Val 
            260                 265                 270         


Asn Lys Gly Leu Val Thr Arg Ala Ser Ala Val Ile Pro Val Ile Pro 
        275                 280                 285             


Leu Tyr Leu Ala Ser Leu Phe Lys Val Met Lys Glu Lys Gly Asn His 
    290                 295                 300                 


Glu Gly Cys Ile Glu Gln Ile Thr Arg Leu Tyr Ala Glu Arg Leu Tyr 
305                 310                 315                 320 


Arg Lys Asp Gly Thr Ile Pro Val Asp Glu Glu Asn Arg Ile Arg Ile 
                325                 330                 335     


Asp Asp Trp Glu Leu Glu Glu Asp Val Gln Lys Ala Val Ser Ala Leu 
            340                 345                 350         


Met Glu Lys Val Thr Gly Glu Asn Ala Glu Ser Leu Thr Asp Leu Ala 
        355                 360                 365             


Gly Tyr Arg His Asp Phe Leu Ala Ser Asn Gly Phe Asp Val Glu Gly 
    370                 375                 380                 


Ile Asn Tyr Glu Ala Glu Val Glu Arg Phe Asp Arg Ile Xaa 
385                 390                 395             


<210>  28
<211>  1407
<212>  DNA
<213>  Clostridium saccharoperbutylacetonicum


<220>
<221>  CDS
<222>  (1)..(1407)

<400>  28
atg att aaa gac acg cta gtt tct ata aca aaa gat tta aaa tta aaa         48
Met Ile Lys Asp Thr Leu Val Ser Ile Thr Lys Asp Leu Lys Leu Lys           
1               5                   10                  15                

aca aat gtt gaa aat gcc aat cta aag aac tac aag gat gat tct tca         96
Thr Asn Val Glu Asn Ala Asn Leu Lys Asn Tyr Lys Asp Asp Ser Ser           
            20                  25                  30                    

tgt ttc gga gtt ttc gaa aat gtt gaa aat gct ata agc aat gcc gta        144
Cys Phe Gly Val Phe Glu Asn Val Glu Asn Ala Ile Ser Asn Ala Val           
        35                  40                  45                        

cac gca caa aag ata tta tcc ctt cat tat aca aaa gaa caa aga gaa        192
His Ala Gln Lys Ile Leu Ser Leu His Tyr Thr Lys Glu Gln Arg Glu           
    50                  55                  60                            

aaa atc ata act gag ata aga aag gcc gca tta gaa aat aaa gag att        240
Lys Ile Ile Thr Glu Ile Arg Lys Ala Ala Leu Glu Asn Lys Glu Ile           
65                  70                  75                  80            

cta gct aca atg att ctt gaa gaa aca cat atg gga aga tat gaa gat        288
Leu Ala Thr Met Ile Leu Glu Glu Thr His Met Gly Arg Tyr Glu Asp           
                85                  90                  95                

aaa ata tta aag cat gaa tta gta gct aaa tac act cct ggg aca gaa        336
Lys Ile Leu Lys His Glu Leu Val Ala Lys Tyr Thr Pro Gly Thr Glu           
            100                 105                 110                   

gat tta act act act gct tgg tca gga gat aac ggg ctt aca gtt gta        384
Asp Leu Thr Thr Thr Ala Trp Ser Gly Asp Asn Gly Leu Thr Val Val           
        115                 120                 125                       

gaa atg tct cca tat ggc gtt ata ggt gca ata act cct tct acg aat        432
Glu Met Ser Pro Tyr Gly Val Ile Gly Ala Ile Thr Pro Ser Thr Asn           
    130                 135                 140                           

cca act gaa act gta ata tgt aat agt ata ggc atg ata gct gct gga        480
Pro Thr Glu Thr Val Ile Cys Asn Ser Ile Gly Met Ile Ala Ala Gly           
145                 150                 155                 160           

aat act gtg gta ttt aac gga cat cca ggc gct aaa aaa tgt gtt gct        528
Asn Thr Val Val Phe Asn Gly His Pro Gly Ala Lys Lys Cys Val Ala           
                165                 170                 175               

ttt gct gtc gaa atg ata aat aaa gct att att tca tgt ggt ggt cct        576
Phe Ala Val Glu Met Ile Asn Lys Ala Ile Ile Ser Cys Gly Gly Pro           
            180                 185                 190                   

gag aat tta gta aca act ata aaa aat cca act atg gac tct cta gat        624
Glu Asn Leu Val Thr Thr Ile Lys Asn Pro Thr Met Asp Ser Leu Asp           
        195                 200                 205                       

gca att att aag cac cct tca ata aaa cta ctt tgc gga act gga ggg        672
Ala Ile Ile Lys His Pro Ser Ile Lys Leu Leu Cys Gly Thr Gly Gly           
    210                 215                 220                           

cca gga atg gta aaa acc ctc tta aat tct ggt aag aaa gct ata ggt        720
Pro Gly Met Val Lys Thr Leu Leu Asn Ser Gly Lys Lys Ala Ile Gly           
225                 230                 235                 240           

gct ggt gct gga aat cca cca gtt att gta gat gat act gct gat ata        768
Ala Gly Ala Gly Asn Pro Pro Val Ile Val Asp Asp Thr Ala Asp Ile           
                245                 250                 255               

gaa aag gct ggt aag agt atc att gaa ggc tgt tct ttt gat aat aat        816
Glu Lys Ala Gly Lys Ser Ile Ile Glu Gly Cys Ser Phe Asp Asn Asn           
            260                 265                 270                   

tta cct tgt att gca gaa aaa gaa gta ttt gtt ttt gag aac gtt gca        864
Leu Pro Cys Ile Ala Glu Lys Glu Val Phe Val Phe Glu Asn Val Ala           
        275                 280                 285                       

gat gat tta ata tct aac atg cta aaa aat aat gct gta att ata aat        912
Asp Asp Leu Ile Ser Asn Met Leu Lys Asn Asn Ala Val Ile Ile Asn           
    290                 295                 300                           

gaa gat caa gta tca aag tta ata gat tta gta tta caa aaa aat aat        960
Glu Asp Gln Val Ser Lys Leu Ile Asp Leu Val Leu Gln Lys Asn Asn           
305                 310                 315                 320           

gaa act caa gaa tac tct ata aat aag aaa tgg gtc gga aaa gat gca       1008
Glu Thr Gln Glu Tyr Ser Ile Asn Lys Lys Trp Val Gly Lys Asp Ala           
                325                 330                 335               

aaa tta ttc tta gat gaa ata gat gtt gag tct cct tca agt gtt aaa       1056
Lys Leu Phe Leu Asp Glu Ile Asp Val Glu Ser Pro Ser Ser Val Lys           
            340                 345                 350                   

tgc ata atc tgc gaa gta agt gca agg cat cca ttt gtt atg aca gaa       1104
Cys Ile Ile Cys Glu Val Ser Ala Arg His Pro Phe Val Met Thr Glu           
        355                 360                 365                       

ctc atg atg cca ata tta cca att gta aga gtt aaa gat ata gat gaa       1152
Leu Met Met Pro Ile Leu Pro Ile Val Arg Val Lys Asp Ile Asp Glu           
    370                 375                 380                           

gct att gaa tat gca aaa ata gca gaa caa aat aga aaa cat agt gcc       1200
Ala Ile Glu Tyr Ala Lys Ile Ala Glu Gln Asn Arg Lys His Ser Ala           
385                 390                 395                 400           

tat att tat tca aaa aat ata gac aac cta aat agg ttt gaa aga gaa       1248
Tyr Ile Tyr Ser Lys Asn Ile Asp Asn Leu Asn Arg Phe Glu Arg Glu           
                405                 410                 415               

atc gat act act atc ttt gta aag aat gct aaa tct ttt gcc ggt gtt       1296
Ile Asp Thr Thr Ile Phe Val Lys Asn Ala Lys Ser Phe Ala Gly Val           
            420                 425                 430                   

ggt tat gaa gca gaa ggc ttt aca act ttc act att gct gga tcc act       1344
Gly Tyr Glu Ala Glu Gly Phe Thr Thr Phe Thr Ile Ala Gly Ser Thr           
        435                 440                 445                       

ggt gaa gga ata act tct gca aga aat ttt aca aga caa aga aga tgt       1392
Gly Glu Gly Ile Thr Ser Ala Arg Asn Phe Thr Arg Gln Arg Arg Cys           
    450                 455                 460                           

gta ctc gcc ggt taa                                                   1407
Val Leu Ala Gly                                                           
465                                                                       


<210>  29
<211>  468
<212>  PRT
<213>  Clostridium saccharoperbutylacetonicum

<400>  29

Met Ile Lys Asp Thr Leu Val Ser Ile Thr Lys Asp Leu Lys Leu Lys 
1               5                   10                  15      


Thr Asn Val Glu Asn Ala Asn Leu Lys Asn Tyr Lys Asp Asp Ser Ser 
            20                  25                  30          


Cys Phe Gly Val Phe Glu Asn Val Glu Asn Ala Ile Ser Asn Ala Val 
        35                  40                  45              


His Ala Gln Lys Ile Leu Ser Leu His Tyr Thr Lys Glu Gln Arg Glu 
    50                  55                  60                  


Lys Ile Ile Thr Glu Ile Arg Lys Ala Ala Leu Glu Asn Lys Glu Ile 
65                  70                  75                  80  


Leu Ala Thr Met Ile Leu Glu Glu Thr His Met Gly Arg Tyr Glu Asp 
                85                  90                  95      


Lys Ile Leu Lys His Glu Leu Val Ala Lys Tyr Thr Pro Gly Thr Glu 
            100                 105                 110         


Asp Leu Thr Thr Thr Ala Trp Ser Gly Asp Asn Gly Leu Thr Val Val 
        115                 120                 125             


Glu Met Ser Pro Tyr Gly Val Ile Gly Ala Ile Thr Pro Ser Thr Asn 
    130                 135                 140                 


Pro Thr Glu Thr Val Ile Cys Asn Ser Ile Gly Met Ile Ala Ala Gly 
145                 150                 155                 160 


Asn Thr Val Val Phe Asn Gly His Pro Gly Ala Lys Lys Cys Val Ala 
                165                 170                 175     


Phe Ala Val Glu Met Ile Asn Lys Ala Ile Ile Ser Cys Gly Gly Pro 
            180                 185                 190         


Glu Asn Leu Val Thr Thr Ile Lys Asn Pro Thr Met Asp Ser Leu Asp 
        195                 200                 205             


Ala Ile Ile Lys His Pro Ser Ile Lys Leu Leu Cys Gly Thr Gly Gly 
    210                 215                 220                 


Pro Gly Met Val Lys Thr Leu Leu Asn Ser Gly Lys Lys Ala Ile Gly 
225                 230                 235                 240 


Ala Gly Ala Gly Asn Pro Pro Val Ile Val Asp Asp Thr Ala Asp Ile 
                245                 250                 255     


Glu Lys Ala Gly Lys Ser Ile Ile Glu Gly Cys Ser Phe Asp Asn Asn 
            260                 265                 270         


Leu Pro Cys Ile Ala Glu Lys Glu Val Phe Val Phe Glu Asn Val Ala 
        275                 280                 285             


Asp Asp Leu Ile Ser Asn Met Leu Lys Asn Asn Ala Val Ile Ile Asn 
    290                 295                 300                 


Glu Asp Gln Val Ser Lys Leu Ile Asp Leu Val Leu Gln Lys Asn Asn 
305                 310                 315                 320 


Glu Thr Gln Glu Tyr Ser Ile Asn Lys Lys Trp Val Gly Lys Asp Ala 
                325                 330                 335     


Lys Leu Phe Leu Asp Glu Ile Asp Val Glu Ser Pro Ser Ser Val Lys 
            340                 345                 350         


Cys Ile Ile Cys Glu Val Ser Ala Arg His Pro Phe Val Met Thr Glu 
        355                 360                 365             


Leu Met Met Pro Ile Leu Pro Ile Val Arg Val Lys Asp Ile Asp Glu 
    370                 375                 380                 


Ala Ile Glu Tyr Ala Lys Ile Ala Glu Gln Asn Arg Lys His Ser Ala 
385                 390                 395                 400 


Tyr Ile Tyr Ser Lys Asn Ile Asp Asn Leu Asn Arg Phe Glu Arg Glu 
                405                 410                 415     


Ile Asp Thr Thr Ile Phe Val Lys Asn Ala Lys Ser Phe Ala Gly Val 
            420                 425                 430         


Gly Tyr Glu Ala Glu Gly Phe Thr Thr Phe Thr Ile Ala Gly Ser Thr 
        435                 440                 445             


Gly Glu Gly Ile Thr Ser Ala Arg Asn Phe Thr Arg Gln Arg Arg Cys 
    450                 455                 460                 


Val Leu Ala Gly 
465             


<210>  30
<211>  1164
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(1164)

<400>  30
atg aac aac ttt aat ctg cac acc cca acc cgc att ctg ttt ggt aaa         48
Met Asn Asn Phe Asn Leu His Thr Pro Thr Arg Ile Leu Phe Gly Lys           
1               5                   10                  15                

ggc gca atc gct ggt tta cgc gaa caa att cct cac gat gct cgc gta         96
Gly Ala Ile Ala Gly Leu Arg Glu Gln Ile Pro His Asp Ala Arg Val           
            20                  25                  30                    

ttg att acc tac ggc ggc ggc agc gtg aaa aaa acc ggc gtt ctc gat        144
Leu Ile Thr Tyr Gly Gly Gly Ser Val Lys Lys Thr Gly Val Leu Asp           
        35                  40                  45                        

caa gtt ctg gat gcc ctg aaa ggc atg gac gtg ctg gaa ttt ggc ggt        192
Gln Val Leu Asp Ala Leu Lys Gly Met Asp Val Leu Glu Phe Gly Gly           
    50                  55                  60                            

att gag cca aac ccg gct tat gaa acg ctg atg aac gcc gtg aaa ctg        240
Ile Glu Pro Asn Pro Ala Tyr Glu Thr Leu Met Asn Ala Val Lys Leu           
65                  70                  75                  80            

gtt cgc gaa cag aaa gtg act ttc ctg ctg gcg gtt ggc ggc ggt tct        288
Val Arg Glu Gln Lys Val Thr Phe Leu Leu Ala Val Gly Gly Gly Ser           
                85                  90                  95                

gta ctg gac ggc acc aaa ttt atc gcc gca gcg gct aac tat ccg gaa        336
Val Leu Asp Gly Thr Lys Phe Ile Ala Ala Ala Ala Asn Tyr Pro Glu           
            100                 105                 110                   

aat atc gat ccg tgg cac att ctg caa acg ggc ggt aaa gag att aaa        384
Asn Ile Asp Pro Trp His Ile Leu Gln Thr Gly Gly Lys Glu Ile Lys           
        115                 120                 125                       

agc gcc atc ccg atg ggc tgt gtg ctg acg ctg cca gca acc ggt tca        432
Ser Ala Ile Pro Met Gly Cys Val Leu Thr Leu Pro Ala Thr Gly Ser           
    130                 135                 140                           

gaa tcc aac gca ggc gcg gtg atc tcc cgt aaa acc aca ggc gac aag        480
Glu Ser Asn Ala Gly Ala Val Ile Ser Arg Lys Thr Thr Gly Asp Lys           
145                 150                 155                 160           

cag gcg ttc cat tct gcc cat gtt cag ccg gta ttt gcc gtg ctc gat        528
Gln Ala Phe His Ser Ala His Val Gln Pro Val Phe Ala Val Leu Asp           
                165                 170                 175               

ccg gtt tat acc tac acc ctg ccg ccg cgt cag gtg gct aac ggc gta        576
Pro Val Tyr Thr Tyr Thr Leu Pro Pro Arg Gln Val Ala Asn Gly Val           
            180                 185                 190                   

gtg gac gcc ttt gta cac acc gtg gaa cag tat gtt acc aaa ccg gtt        624
Val Asp Ala Phe Val His Thr Val Glu Gln Tyr Val Thr Lys Pro Val           
        195                 200                 205                       

gat gcc aaa att cag gac cgt ttc gca gaa ggc att ttg ctg acg cta        672
Asp Ala Lys Ile Gln Asp Arg Phe Ala Glu Gly Ile Leu Leu Thr Leu           
    210                 215                 220                           

atc gaa gat ggt ccg aaa gcc ctg aaa gag cca gaa aac tac gat gtg        720
Ile Glu Asp Gly Pro Lys Ala Leu Lys Glu Pro Glu Asn Tyr Asp Val           
225                 230                 235                 240           

cgc gcc aac gtc atg tgg gcg gcg act cag gcg ctg aac ggt ttg att        768
Arg Ala Asn Val Met Trp Ala Ala Thr Gln Ala Leu Asn Gly Leu Ile           
                245                 250                 255               

ggc gct ggc gta ccg cag gac tgg gca acg cat atg ctg ggc cac gaa        816
Gly Ala Gly Val Pro Gln Asp Trp Ala Thr His Met Leu Gly His Glu           
            260                 265                 270                   

ctg act gcg atg cac ggt ctg gat cac gcg caa aca ctg gct atc gtc        864
Leu Thr Ala Met His Gly Leu Asp His Ala Gln Thr Leu Ala Ile Val           
        275                 280                 285                       

ctg cct gca ctg tgg aat gaa aaa cgc gat acc aag cgc gct aag ctg        912
Leu Pro Ala Leu Trp Asn Glu Lys Arg Asp Thr Lys Arg Ala Lys Leu           
    290                 295                 300                           

ctg caa tat gct gaa cgc gtc tgg aac atc act gaa ggt tcc gat gat        960
Leu Gln Tyr Ala Glu Arg Val Trp Asn Ile Thr Glu Gly Ser Asp Asp           
305                 310                 315                 320           

gag cgt att gac gcc gcg att gcc gca acc cgc aat ttc ttt gag caa       1008
Glu Arg Ile Asp Ala Ala Ile Ala Ala Thr Arg Asn Phe Phe Glu Gln           
                325                 330                 335               

tta ggc gtg ccg acc cac ctc tcc gac tac ggt ctg gac ggc agc tcc       1056
Leu Gly Val Pro Thr His Leu Ser Asp Tyr Gly Leu Asp Gly Ser Ser           
            340                 345                 350                   

atc ccg gct ttg ctg aaa aaa ctg gaa gag cac ggc atg acc caa ctg       1104
Ile Pro Ala Leu Leu Lys Lys Leu Glu Glu His Gly Met Thr Gln Leu           
        355                 360                 365                       

ggc gaa aat cat gac att acg ttg gat gtc agc cgc cgt ata tac gaa       1152
Gly Glu Asn His Asp Ile Thr Leu Asp Val Ser Arg Arg Ile Tyr Glu           
    370                 375                 380                           

gcc gcc cgc taa                                                       1164
Ala Ala Arg                                                               
385                                                                       


<210>  31
<211>  387
<212>  PRT
<213>  Escherichia coli

<400>  31

Met Asn Asn Phe Asn Leu His Thr Pro Thr Arg Ile Leu Phe Gly Lys 
1               5                   10                  15      


Gly Ala Ile Ala Gly Leu Arg Glu Gln Ile Pro His Asp Ala Arg Val 
            20                  25                  30          


Leu Ile Thr Tyr Gly Gly Gly Ser Val Lys Lys Thr Gly Val Leu Asp 
        35                  40                  45              


Gln Val Leu Asp Ala Leu Lys Gly Met Asp Val Leu Glu Phe Gly Gly 
    50                  55                  60                  


Ile Glu Pro Asn Pro Ala Tyr Glu Thr Leu Met Asn Ala Val Lys Leu 
65                  70                  75                  80  


Val Arg Glu Gln Lys Val Thr Phe Leu Leu Ala Val Gly Gly Gly Ser 
                85                  90                  95      


Val Leu Asp Gly Thr Lys Phe Ile Ala Ala Ala Ala Asn Tyr Pro Glu 
            100                 105                 110         


Asn Ile Asp Pro Trp His Ile Leu Gln Thr Gly Gly Lys Glu Ile Lys 
        115                 120                 125             


Ser Ala Ile Pro Met Gly Cys Val Leu Thr Leu Pro Ala Thr Gly Ser 
    130                 135                 140                 


Glu Ser Asn Ala Gly Ala Val Ile Ser Arg Lys Thr Thr Gly Asp Lys 
145                 150                 155                 160 


Gln Ala Phe His Ser Ala His Val Gln Pro Val Phe Ala Val Leu Asp 
                165                 170                 175     


Pro Val Tyr Thr Tyr Thr Leu Pro Pro Arg Gln Val Ala Asn Gly Val 
            180                 185                 190         


Val Asp Ala Phe Val His Thr Val Glu Gln Tyr Val Thr Lys Pro Val 
        195                 200                 205             


Asp Ala Lys Ile Gln Asp Arg Phe Ala Glu Gly Ile Leu Leu Thr Leu 
    210                 215                 220                 


Ile Glu Asp Gly Pro Lys Ala Leu Lys Glu Pro Glu Asn Tyr Asp Val 
225                 230                 235                 240 


Arg Ala Asn Val Met Trp Ala Ala Thr Gln Ala Leu Asn Gly Leu Ile 
                245                 250                 255     


Gly Ala Gly Val Pro Gln Asp Trp Ala Thr His Met Leu Gly His Glu 
            260                 265                 270         


Leu Thr Ala Met His Gly Leu Asp His Ala Gln Thr Leu Ala Ile Val 
        275                 280                 285             


Leu Pro Ala Leu Trp Asn Glu Lys Arg Asp Thr Lys Arg Ala Lys Leu 
    290                 295                 300                 


Leu Gln Tyr Ala Glu Arg Val Trp Asn Ile Thr Glu Gly Ser Asp Asp 
305                 310                 315                 320 


Glu Arg Ile Asp Ala Ala Ile Ala Ala Thr Arg Asn Phe Phe Glu Gln 
                325                 330                 335     


Leu Gly Val Pro Thr His Leu Ser Asp Tyr Gly Leu Asp Gly Ser Ser 
            340                 345                 350         


Ile Pro Ala Leu Leu Lys Lys Leu Glu Glu His Gly Met Thr Gln Leu 
        355                 360                 365             


Gly Glu Asn His Asp Ile Thr Leu Asp Val Ser Arg Arg Ile Tyr Glu 
    370                 375                 380                 


Ala Ala Arg 
385         


