                         SEQUENCE LISTING

<110>  MODERNA THERAPEUTICS, INC.
 
<120>  COMPOSITIONS AND METHODS OF ALTERING CHOLESTEROL LEVELS

<130>  M044.20/2030.1044PCT

<140>  PCT/US2014/XXXXXX
<141>  2014-03-14

<150>  US 61/786,737
<151>  2013-03-15

<150>  US 61/828,214
<151>  2013-05-29

<150>  US 61/839,448
<151>  2013-06-26

<150>  US 61/903,474
<151>  2013-11-13

<150>  US 14/135,887
<151>  2013-12-20

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  2333
<212>  DNA
<213>  Homo sapiens

<400>  1
gtgcaatcgc gggaagccag ggtttccagc taggacacag caggtcgtga tccgggtcgg       60

gacactgcct ggcagaggct gcgagcatgg ggccctgggg ctggaaattg cgctggaccg      120

tcgccttgct cctcgccgcg gcggggactg cagtgggcga cagatgcgaa agaaacgagt      180

tccagtgcca agacgggaaa tgcatctcct acaagtgggt ctgcgatggc agcgctgagt      240

gccaggatgg ctctgatgag tcccaggaga cgtgcttgtc tgtcacctgc aaatccgggg      300

acttcagctg tgggggccgt gtcaaccgct gcattcctca gttctggagg tgcgatggcc      360

aagtggactg cgacaacggc tcagacgagc aaggctgtct gacactctgc gagggaccca      420

acaagttcaa gtgtcacagc ggcgaatgca tcaccctgga caaagtctgc aacatggcta      480

gagactgccg ggactggtca gatgaaccca tcaaagagtg cgggaccaac gaatgcttgg      540

acaacaacgg cggctgttcc cacgtctgca atgaccttaa gatcggctac gagtgcctgt      600

gccccgacgg cttccagctg gtggcccagc gaagatgcga agatatcgat gagtgtcagg      660

atcccgacac ctgcagccag ctctgcgtga acctggaggg tggctacaag tgccagtgtg      720

aggaaggctt ccagctggac ccccacacga aggcctgcaa ggctgtgggc tccatcgcct      780

acctcttctt caccaaccgg cacgaggtca ggaagatgac gctggaccgg agcgagtaca      840

ccagcctcat ccccaacctg aggaacgtgg tcgctctgga cacggaggtg gccagcaata      900

gaatctactg gtctgacctg tcccagagaa tgatctgcag cacccagctt gacagagccc      960

acggcgtctc ttcctatgac accgtcatca gcagagacat ccaggccccc gacgggctgg     1020

ctgtggactg gatccacagc aacatctact ggaccgactc tgtcctgggc actgtctctg     1080

ttgcggatac caagggcgtg aagaggaaaa cgttattcag ggagaacggc tccaagccaa     1140

gggccatcgt ggtggatcct gttcatggct tcatgtactg gactgactgg ggaactcccg     1200

ccaagatcaa gaaagggggc ctgaatggtg tggacatcta ctcgctggtg actgaaaaca     1260

ttcagtggcc caatggcatc accctagatc tcctcagtgg ccgcctctac tgggttgact     1320

ccaaacttca ctccatctca agcatcgatg tcaacggggg caaccggaag accatcttgg     1380

aggatgaaaa gaggctggcc caccccttct ccttggccgt ctttgaggac aaagtatttt     1440

ggacagatat catcaacgaa gccattttca gtgccaaccg cctcacaggt tccgatgtca     1500

acttgttggc tgaaaaccta ctgtccccag aggatatggt tctcttccac aacctcaccc     1560

agccaagagg agtgaactgg tgtgagagga ccaccctgag caatggcggc tgccagtatc     1620

tgtgcctccc tgccccgcag atcaaccccc actcgcccaa gtttacctgc gcctgcccgg     1680

acggcatgct gctggccagg gacatgagga gctgcctcac agaggctgag gctgcagtgg     1740

ccacccagga gacatccacc gtcaggctaa aggtcagctc cacagccgta aggacacagc     1800

acacaaccac ccgacctgtt cccgacacct cccggctgcc tggggccacc cctgggctca     1860

ccacggtgga gatagtgaca atgtctcacc aagctctggg cgacgttgct ggcagaggaa     1920

atgagaagaa gcccagtagc gtgagggctc tgtccattgt cctccccatc gtgctcctcg     1980

tcttcctttg cctgggggtc ttccttctat ggaagaactg gcggcttaag aacatcaaca     2040

gcatcaactt tgacaacccc gtctatcaga agaccacaga ggatgaggtc cacatttgcc     2100

acaaccagga cggctacagc tacccctcga gacagatggt cagtctggag gatgacgtgg     2160

cgtgaacatc tgcctggagt cccgtccctg cccagaaccc ttcctgagac ctcgccggcc     2220

ttgttttatt caaagacaga gaagaccaaa gcattgcctg ccagagcttt gttttatata     2280

tttattcatc tgggaggcag aacaggcttc ggacagtgcc catgcaatgg ctt            2333


<210>  2
<211>  2220
<212>  DNA
<213>  Homo sapiens

<400>  2
atggggccct ggggctggaa attgcgctgg accgtcgcct tgctcctcgc cgcggcgggg       60

actgcagtgg gcgacagatg cgaaagaaac gacttccagt gcaacagctc cacctgcatc      120

ccccagctgt gggcctgcga caacgacccc gactgcgaag atggctcgga tgagtggccg      180

cagcgctgta ggggtcttta cgtgttccaa ggggacagta gcccctgctc ggccttcgag      240

ttccactgcc taagtggcga gtgcatccac tccagctggc gctgtgatgg tggccccgac      300

tgcaaggaca aatctgacga ggaaaactgc gctgtggcca cctgtcgccc tgacgaattc      360

cagtgctctg atggaaactg catccatggc agccggcagt gtgaccggga atatgactgc      420

aaggacatga gcgatgaagt tggctgcgtt aatgtgacac tctgcgaggg acccaacaag      480

ttcaagtgtc acagcggcga atgcatcacc ctggacaaag tctgcaacat ggctagagac      540

tgccgggact ggtcagatga acccatcaaa gagtgcggga ccaacgaatg cttggacaac      600

aacggcggct gttcccacgt ctgcaatgac cttaagatcg gctacgagtg cctgtgcccc      660

gacggcttcc agctggtggc ccagcgaaga tgcgaagata tcgatgagtg tcaggatccc      720

gacacctgca gccagctctg cgtgaacctg gagggtggct acaagtgcca gtgtgaggaa      780

ggcttccagc tggaccccca cacgaaggcc tgcaaggctg tgggctccat cgcctacctc      840

ttcttcacca accggcacga ggtcaggaag atgacgctgg accggagcga gtacaccagc      900

ctcatcccca acctgaggaa cgtggtcgct ctggacacgg aggtggccag caatagaatc      960

tactggtctg acctgtccca gagaatgatc tgcagcaccc agcttgacag agcccacggc     1020

gtctcttcct atgacaccgt catcagcaga gacatccagg cccccgacgg gctggctgtg     1080

gactggatcc acagcaacat ctactggacc gactctgtcc tgggcactgt ctctgttgcg     1140

gataccaagg gcgtgaagag gaaaacgtta ttcagggaga acggctccaa gccaagggcc     1200

atcgtggtgg atcctgttca tggcttcatg tactggactg actggggaac tcccgccaag     1260

atcaagaaag ggggcctgaa tggtgtggac atctactcgc tggtgactga aaacattcag     1320

tggcccaatg gcatcaccct agatctcctc agtggccgcc tctactgggt tgactccaaa     1380

cttcactcca tctcaagcat cgatgtcaac gggggcaacc ggaagaccat cttggaggat     1440

gaaaagaggc tggcccaccc cttctccttg gccgtctttg aggacaaagt attttggaca     1500

gatatcatca acgaagccat tttcagtgcc aaccgcctca caggttccga tgtcaacttg     1560

ttggctgaaa acctactgtc cccagaggat atggttctct tccacaacct cacccagcca     1620

agaggagtga actggtgtga gaggaccacc ctgagcaatg gcggctgcca gtatctgtgc     1680

ctccctgccc cgcagatcaa cccccactcg cccaagttta cctgcgcctg cccggacggc     1740

atgctgctgg ccagggacat gaggagctgc ctcacagagg ctgaggctgc agtggccacc     1800

caggagacat ccaccgtcag gctaaaggtc agctccacag ccgtaaggac acagcacaca     1860

accacccgac ctgttcccga cacctcccgg ctgcctgggg ccacccctgg gctcaccacg     1920

gtggagatag tgacaatgtc tcaccaagct ctgggcgacg ttgctggcag aggaaatgag     1980

aagaagccca gtagcgtgag ggctctgtcc attgtcctcc ccatcgtgct cctcgtcttc     2040

ctttgcctgg gggtcttcct tctatggaag aactggcggc ttaagaacat caacagcatc     2100

aactttgaca accccgtcta tcagaagacc acagaggatg aggtccacat ttgccacaac     2160

caggacggct acagctaccc ctcgagacag atggtcagtc tggaggatga cgtggcgtga     2220


<210>  3
<211>  3617
<212>  DNA
<213>  Homo sapiens

<400>  3
ctcttgcagt gaggtgaaga catttgaaaa tcaccccact gcaaactcct ccccctgcta       60

gaaacctcac attgaaatgc tgtaaatgac gtgggccccg agtgcaatcg cgggaagcca      120

gggtttccag ctaggacaca gcaggtcgtg atccgggtcg ggacactgcc tggcagaggc      180

tgcgagcatg gggccctggg gctggaaatt gcgctggacc gtcgccttgc tcctcgccgc      240

ggcggggact gcagtgggcg acagatgcga aagaaacgag ttccagtgcc aagacgggaa      300

atgcatctcc tacaagtggg tctgcgatgg cagcgctgag tgccaggatg gctctgatga      360

gtcccaggag acgtgcttgt ctgtcacctg caaatccggg gacttcagct gtgggggccg      420

tgtcaaccgc tgcattcctc agttctggag gtgcgatggc caagtggact gcgacaacgg      480

ctcagacgag caaggctgtc cccccaagac gtgctcccag gacgagtttc gctgccacga      540

tgggaagtgc atctctcggc agttcgtctg tgactcagac cgggactgct tggacggctc      600

agacgaggcc tcctgcccgg tgctcacctg tggtcccgcc agcttccagt gcaacagctc      660

cacctgcatc ccccagctgt gggcctgcga caacgacccc gactgcgaag atggctcgga      720

tgagtggccg cagcgctgta ggggtcttta cgtgttccaa ggggacagta gcccctgctc      780

ggccttcgag ttccactgcc taagtggcga gtgcatccac tccagctggc gctgtgatgg      840

tggccccgac tgcaaggaca aatctgacga ggaaaactgc gctgtggcca cctgtcgccc      900

tgacgaattc cagtgctctg atggaaactg catccatggc agccggcagt gtgaccggga      960

atatgactgc aaggacatga gcgatgaagt tggctgcgtt aatgtgacac tctgcgaggg     1020

acccaacaag ttcaagtgtc acagcggcga atgcatcacc ctggacaaag tctgcaacat     1080

ggctagagac tgccgggact ggtcagatga acccatcaaa gagtgcggga ccaacgaatg     1140

cttggacaac aacggcggct gttcccacgt ctgcaatgac cttaagatcg gctacgagtg     1200

cctgtgcccc gacggcttcc agctggtggc ccagcgaaga tgcgaagata tcgatgagtg     1260

tcaggatccc gacacctgca gccagctctg cgtgaacctg gagggtggct acaagtgcca     1320

gtgtgaggaa ggcttccagc tggaccccca cacgaaggcc tgcaaggctg tgggctccat     1380

cgcctacctc ttcttcacca accggcacga ggtcaggaag atgacgctgg accggagcga     1440

gtacaccagc ctcatcccca acctgaggaa cgtggtcgct ctggacacgg aggtggccag     1500

caatagaatc tactggtctg acctgtccca gagaatgatc tgcagcaccc agcttgacag     1560

agcccacggc gtctcttcct atgacaccgt catcagcaga gacatccagg cccccgacgg     1620

gctggctgtg gactggatcc acagcaacat ctactggacc gactctgtcc tgggcactgt     1680

ctctgttgcg gataccaagg gcgtgaagag gaaaacgtta ttcagggaga acggctccaa     1740

gccaagggcc atcgtggtgg atcctgttca tggcttcatg tactggactg actggggaac     1800

tcccgccaag atcaagaaag ggggcctgaa tggtgtggac atctactcgc tggtgactga     1860

aaacattcag tggcccaatg gcatcaccct agatctcctc agtggccgcc tctactgggt     1920

tgactccaaa cttcactcca tctcaagcat cgatgtcaac gggggcaacc ggaagaccat     1980

cttggaggat gaaaagaggc tggcccaccc cttctccttg gccgtctttg aggacaaagt     2040

attttggaca gatatcatca acgaagccat tttcagtgcc aaccgcctca caggttccga     2100

tgtcaacttg ttggctgaaa acctactgtc cccagaggat atggttctct tccacaacct     2160

cacccagcca agaggagtga actggtgtga gaggaccacc ctgagcaatg gcggctgcca     2220

gtatctgtgc ctccctgccc cgcagatcaa cccccactcg cccaagttta cctgcgcctg     2280

cccggacggc atgctgctgg ccagggacat gaggagctgc ctcacagagg ctgaggctgc     2340

agtggccacc caggagacat ccaccgtcag gctaaaggtc agctccacag ccgtaaggac     2400

acagcacaca accacccgac ctgttcccga cacctcccgg ctgcctgggg ccacccctgg     2460

gctcaccacg gtggagatag tgacaatgtc tcaccaagct ctgggcgacg ttgctggcag     2520

aggaaatgag aagaagccca gtagcgtgag ggctctgtcc attgtcctcc ccatcgtgct     2580

cctcgtcttc ctttgcctgg gggtcttcct tctatggaag aactggcggc ttaagaacat     2640

caacagcatc aactttgaca accccgtcta tcagaagacc acagaggatg aggtccacat     2700

ttgccacaac caggacggct acagctaccc ctcgagacag atggtcagtc tggaggatga     2760

cgtggcgtga acatctgcct ggagtcccgt ccctgcccag aacccttcct gagacctcgc     2820

cggccttgtt ttattcaaag acagagaaga ccaaagcatt gcctgccaga gctttgtttt     2880

atatatttat tcatctggga ggcagaacag gcttcggaca gtgcccatgc aatggcttgg     2940

gttgggattt tggtttcttc ctttcctcgt gaaggataag agaaacaggc ccggggggac     3000

caggatgaca cctccatttc tctccaggaa gttttgagtt tctctccacc gtgacacaat     3060

cctcaaacat ggaagatgaa aggggagggg atgtcaggcc cagagaagca agtggctttc     3120

aacacacaac agcagatggc accaacggga ccccctggcc ctgcctcatc caccaatctc     3180

taagccaaac ccctaaactc aggagtcaac gtgtttacct cttctatgca agccttgcta     3240

gacagccagg ttagcctttg ccctgtcacc cccgaatcat gacccaccca gtgtctttcg     3300

aggtgggttt gtaccttcct taagccagga aagggattca tggcgtcgga aatgatctgg     3360

ctgaatccgt ggtggcaccg agaccaaact cattcaccaa atgatgccac ttcccagagg     3420

cagagcctga gtcactggtc acccttaata tttattaagt gcctgagaca cccggttacc     3480

ttggccgtga ggacacgtgg cctgcaccca ggtgtggctg tcaggacacc agcctggtgc     3540

ccatcctccc gacccctacc cacttccatt cccgtggtct ccttgcactt tctcagttca     3600

gagttgtaca ctgtgta                                                    3617


<210>  4
<211>  3144
<212>  DNA
<213>  Homo sapiens

<400>  4
gccagggttt ccagctagga cacagcaggt cgtgatccgg gtcgggacac tgcctggcag       60

aggctgcgag catggggccc tggggctgga aattgcgctg gaccgtcgcc ttgctcctcg      120

ccgcggcggg gactgcagtg ggcgacagat gcgaaagaaa cgagttccag tgccaagacg      180

ggaaatgcat ctcctacaag tgggtctgcg atggcagcgc tgagtgccag gatggctctg      240

atgagtccca ggagacgtgc ttgtctgtca cctgcaaatc cggggacttc agctgtgggg      300

gccgtgtcaa ccgctgcatt cctcagttct ggaggtgcga tggccaagtg gactgcgaca      360

acggctcaga cgagcaaggc tgtcccccca agacgtgctc ccaggacgag tttcgctgcc      420

acgatgggaa gtgcatctct cggcagttcg tctgtgactc agaccgggac tgcttggacg      480

gctcagacga ggcctcctgc ccggtgctca cctgtggtcc cgccagcttc cagtgcaaca      540

gctccacctg catcccccag ctgtgggcct gcgacaacga ccccgactgc gaagatggct      600

cggatgagtg gccgcagcgc tgtaggggtc tttacgtgtt ccaaggggac agtagcccct      660

gctcggcctt cgagttccac tgcctaagtg gcgagtgcat ccactccagc tggcgctgtg      720

atggtggccc cgactgcaag gacaaatctg acgaggaaaa ctgcgctgtg gccacctgtc      780

gccctgacga attccagtgc tctgatggaa actgcatcca tggcagccgg cagtgtgacc      840

gggaatatga ctgcaaggac atgagcgatg aagttggctg cgttaatgtg acactctgcg      900

agggacccaa caagttcaag tgtcacagcg gcgaatgcat caccctggac aaagtctgca      960

acatggctag agactgccgg gactggtcag atgaacccat caaagagtgc gggaccaacg     1020

aatgcttgga caacaacggc ggctgttccc acgtctgcaa tgaccttaag atcggctacg     1080

agtgcctgtg ccccgacggc ttccagctgg tggcccagcg aagatgcgaa gatatcgatg     1140

agtgtcagga tcccgacacc tgcagccagc tctgcgtgaa cctggagggt ggctacaagt     1200

gccagtgtga ggaaggcttc cagctggacc cccacacgaa ggcctgcaag gctgtgggct     1260

ccatcgccta cctcttcttc accaaccggc acgaggtcag gaagatgacg ctggaccgga     1320

gcgagtacac cagcctcatc cccaacctga ggaacgtggt cgctctggac acggaggtgg     1380

ccagcaatag aatctactgg tctgacctgt cccagagaat gatctgcagc acccagcttg     1440

acagagccca cggcgtctct tcctatgaca ccgtcatcag cagagacatc caggcccccg     1500

acgggctggc tgtggactgg atccacagca acatctactg gaccgactct gtcctgggca     1560

ctgtctctgt tgcggatacc aagggcgtga agaggaaaac gttattcagg gagaacggct     1620

ccaagccaag ggccatcgtg gtggatcctg ttcatggctt catgtactgg actgactggg     1680

gaactcccgc caagatcaag aaagggggcc tgaatggtgt ggacatctac tcgctggtga     1740

ctgaaaacat tcagtggccc aatggcatca ccctagatct cctcagtggc cgcctctact     1800

gggttgactc caaacttcac tccatctcaa gcatcgatgt caacgggggc aaccggaaga     1860

ccatcttgga ggatgaaaag aggctggccc accccttctc cttggccgtc tttgaggaca     1920

aagtattttg gacagatatc atcaacgaag ccattttcag tgccaaccgc ctcacaggtt     1980

ccgatgtcaa cttgttggct gaaaacctac tgtccccaga ggatatggtt ctcttccaca     2040

acctcaccca gccaagagga gtgaactggt gtgagaggac caccctgagc aatggcggct     2100

gccagtatct gtgcctccct gccccgcaga tcaaccccca ctcgcccaag tttacctgcg     2160

cctgcccgga cggcatgctg ctggccaggg acatgaggag ctgcctcaca gaggctgagg     2220

ctgcagtggc cacccaggag acatccaccg tcaggctaaa ggtcagctcc acagccgtaa     2280

ggacacagca cacaaccacc cgacctgttc ccgacacctc ccggctgcct ggggccaccc     2340

ctgggctcac cacggtggag atagtgacaa tgtctcacca agctctgggc gacgttgctg     2400

gcagaggaaa tgagaagaag cccagtagcg tgagggctct gtccattgtc ctccccatcg     2460

tgctcctcgt cttcctttgc ctgggggtct tccttctatg gaagaactgg cggcttaaga     2520

acatcaacag catcaacttt gacaaccccg tctatcagaa gaccacagag gatgaggtcc     2580

acatttgcca caaccaggac ggctacagct acccctcgat ggtcagtctg gaggatgacg     2640

tggcgtgaac atctgcctgg agtcccgtcc ctgcccagaa cccttcctga gacctcgccg     2700

gccttgtttt attcaaagac agagaagacc aaagcattgc ctgccagagc tttgttttat     2760

atatttattc atctgggagg cagaacaggc ttcggacagt gcccatgcaa tggcttgggt     2820

tgggattttg gtttcttcct ttcctcgtga aggataagag aaacaggccc ggggggacca     2880

ggatgacacc tccatttctc tccaggaagt tttgagtttc tctccaccgt gacacaatcc     2940

tcaaacatgg aagatgaaag gggaggggat gtcaggccca gagaagcaag tggctttcaa     3000

cacacaacag cagatggcac caacgggacc ccctggccct gcctcatcca ccaatctcta     3060

agccaaaccc ctaaactcag gagtcaacgt gtttacctct tctatgcaag ccttgctaga     3120

cagccaggtt agcctttgcc ctgt                                            3144


<210>  5
<211>  2768
<212>  DNA
<213>  Homo sapiens

<400>  5
gtgcaatcgc gggaagccag ggtttccagc taggacacag caggtcgtga tccgggtcgg       60

gacactgcct ggcagaggct gcgagcatgg ggccctgggg ctggaaattg cgctggaccg      120

tcgccttgct cctcgccgcg gcggggactg cagtgggcga cagatgcgaa agaaacgagt      180

tccagtgcca agacgggaaa tgcatctcct acaagtgggt ctgcgatggc agcgctgagt      240

gccaggatgg ctctgatgag tcccaggaga cgtgctcccc caagacgtgc tcccaggacg      300

agtttcgctg ccacgatggg aagtgcatct ctcggcagtt cgtctgtgac tcagaccggg      360

actgcttgga cggctcagac gaggcctcct gcccggtgct cacctgtggt cccgccagct      420

tccagtgcaa cagctccacc tgcatccccc agctgtgggc ctgcgacaac gaccccgact      480

gcgaagatgg ctcggatgag tggccgcagc gctgtagggg tctttacgtg ttccaagggg      540

acagtagccc ctgctcggcc ttcgagttcc actgcctaag tggcgagtgc atccactcca      600

gctggcgctg tgatggtggc cccgactgca aggacaaatc tgacgaggaa aactgcgctg      660

tggccacctg tcgccctgac gaattccagt gctctgatgg aaactgcatc catggcagcc      720

ggcagtgtga ccgggaatat gactgcaagg acatgagcga tgaagttggc tgcgttaatg      780

tgacactctg cgagggaccc aacaagttca agtgtcacag cggcgaatgc atcaccctgg      840

acaaagtctg caacatggct agagactgcc gggactggtc agatgaaccc atcaaagagt      900

gcgggaccaa cgaatgcttg gacaacaacg gcggctgttc ccacgtctgc aatgacctta      960

agatcggcta cgagtgcctg tgccccgacg gcttccagct ggtggcccag cgaagatgcg     1020

aagatatcga tgagtgtcag gatcccgaca cctgcagcca gctctgcgtg aacctggagg     1080

gtggctacaa gtgccagtgt gaggaaggct tccagctgga cccccacacg aaggcctgca     1140

aggctgtggg ctccatcgcc tacctcttct tcaccaaccg gcacgaggtc aggaagatga     1200

cgctggaccg gagcgagtac accagcctca tccccaacct gaggaacgtg gtcgctctgg     1260

acacggaggt ggccagcaat agaatctact ggtctgacct gtcccagaga atgatctgca     1320

gcacccagct tgacagagcc cacggcgtct cttcctatga caccgtcatc agcagagaca     1380

tccaggcccc cgacgggctg gctgtggact ggatccacag caacatctac tggaccgact     1440

ctgtcctggg cactgtctct gttgcggata ccaagggcgt gaagaggaaa acgttattca     1500

gggagaacgg ctccaagcca agggccatcg tggtggatcc tgttcatggc ttcatgtact     1560

ggactgactg gggaactccc gccaagatca agaaaggggg cctgaatggt gtggacatct     1620

actcgctggt gactgaaaac attcagtggc ccaatggcat caccctagat ctcctcagtg     1680

gccgcctcta ctgggttgac tccaaacttc actccatctc aagcatcgat gtcaacgggg     1740

gcaaccggaa gaccatcttg gaggatgaaa agaggctggc ccaccccttc tccttggccg     1800

tctttgagga caaagtattt tggacagata tcatcaacga agccattttc agtgccaacc     1860

gcctcacagg ttccgatgtc aacttgttgg ctgaaaacct actgtcccca gaggatatgg     1920

ttctcttcca caacctcacc cagccaagag gagtgaactg gtgtgagagg accaccctga     1980

gcaatggcgg ctgccagtat ctgtgcctcc ctgccccgca gatcaacccc cactcgccca     2040

agtttacctg cgcctgcccg gacggcatgc tgctggccag ggacatgagg agctgcctca     2100

cagaggctga ggctgcagtg gccacccagg agacatccac cgtcaggcta aaggtcagct     2160

ccacagccgt aaggacacag cacacaacca cccgacctgt tcccgacacc tcccggctgc     2220

ctggggccac ccctgggctc accacggtgg agatagtgac aatgtctcac caagctctgg     2280

gcgacgttgc tggcagagga aatgagaaga agcccagtag cgtgagggct ctgtccattg     2340

tcctccccat cgtgctcctc gtcttccttt gcctgggggt cttccttcta tggaagaact     2400

ggcggcttaa gaacatcaac agcatcaact ttgacaaccc cgtctatcag aagaccacag     2460

aggatgaggt ccacatttgc cacaaccagg acggctacag ctacccctcg agacagatgg     2520

tcagtctgga ggatgacgtg gcgtgaacat ctgcctggag tcccgtccct gcccagaacc     2580

cttcctgaga cctcgccggc cttgttttat tcaaagacag agaagaccaa agcattgcct     2640

gccagagctt tgttttatat atttattcat ctgggaggca gaacaggctt cggacagtgc     2700

ccatgcaatg gcttgggttg ggattttggt ttcttccttt cctcgtgaag gataagagaa     2760

acaggccc                                                              2768


<210>  6
<211>  2429
<212>  DNA
<213>  Homo sapiens

<400>  6
gtgcaatcgc gggaagccag ggtttccagc taggacacag caggtcgtga tccgggtcgg       60

gacactgcct ggcagaggct gcgagcatgg ggccctgggg ctggaaattg cgctggaccg      120

tcgccttgct cctcgccgcg gcggggactg cagtgggcga cagatgcgaa agaaacgagt      180

tccagtgcca agacgggaaa tgcatctcct acaagtgggt ctgcgatggc agcgctgagt      240

gccaggatgg ctctgatgag tcccaggaga cgtgcttgtc tgtcacctgc aaatccgggg      300

acttcagctg tgggggccgt gtcaaccgct gcattcctca gttctggagg tgcgatggcc      360

aagtggactg cgacaacggc tcagacgagc aaggctgtcc tgtggccacc tgtcgccctg      420

acgaattcca gtgctctgat ggaaactgca tccatggcag ccggcagtgt gaccgggaat      480

atgactgcaa ggacatgagc gatgaagttg gctgcgttaa tgtgacactc tgcgagggac      540

ccaacaagtt caagtgtcac agcggcgaat gcatcaccct ggacaaagtc tgcaacatgg      600

ctagagactg ccgggactgg tcagatgaac ccatcaaaga gtgcgggacc aacgaatgct      660

tggacaacaa cggcggctgt tcccacgtct gcaatgacct taagatcggc tacgagtgcc      720

tgtgccccga cggcttccag ctggtggccc agcgaagatg cgaagatatc gatgagtgtc      780

aggatcccga cacctgcagc cagctctgcg tgaacctgga gggtggctac aagtgccagt      840

gtgaggaagg cttccagctg gacccccaca cgaaggcctg caaggctgtg ggctccatcg      900

cctacctctt cttcaccaac cggcacgagg tcaggaagat gacgctggac cggagcgagt      960

acaccagcct catccccaac ctgaggaacg tggtcgctct ggacacggag gtggccagca     1020

atagaatcta ctggtctgac ctgtcccaga gaatgatctg cagcacccag cttgacagag     1080

cccacggcgt ctcttcctat gacaccgtca tcagcagaga catccaggcc cccgacgggc     1140

tggctgtgga ctggatccac agcaacatct actggaccga ctctgtcctg ggcactgtct     1200

ctgttgcgga taccaagggc gtgaagagga aaacgttatt cagggagaac ggctccaagc     1260

caagggccat cgtggtggat cctgttcatg gcttcatgta ctggactgac tggggaactc     1320

ccgccaagat caagaaaggg ggcctgaatg gtgtggacat ctactcgctg gtgactgaaa     1380

acattcagtg gcccaatggc atcaccctag atctcctcag tggccgcctc tactgggttg     1440

actccaaact tcactccatc tcaagcatcg atgtcaacgg gggcaaccgg aagaccatct     1500

tggaggatga aaagaggctg gcccacccct tctccttggc cgtctttgag gacaaagtat     1560

tttggacaga tatcatcaac gaagccattt tcagtgccaa ccgcctcaca ggttccgatg     1620

tcaacttgtt ggctgaaaac ctactgtccc cagaggatat ggttctcttc cacaacctca     1680

cccagccaag agaggctgag gctgcagtgg ccacccagga gacatccacc gtcaggctaa     1740

aggtcagctc cacagccgta aggacacagc acacaaccac ccgacctgtt cccgacacct     1800

cccggctgcc tggggccacc cctgggctca ccacggtgga gatagtgaca atgtctcacc     1860

aagctctggg cgacgttgct ggcagaggaa atgagaagaa gcccagtagc gtgagggctc     1920

tgtccattgt cctccccatc gtgctcctcg tcttcctttg cctgggggtc ttccttctat     1980

ggaagaactg gcggcttaag aacatcaaca gcatcaactt tgacaacccc gtctatcaga     2040

agaccacaga ggatgaggtc cacatttgcc acaaccagga cggctacagc tacccctcga     2100

gacagatggt cagtctggag gatgacgtgg cgtgaacatc tgcctggagt cccgtccctg     2160

cccagaaccc ttcctgagac ctcgccggcc ttgttttatt caaagacaga gaagaccaaa     2220

gcattgcctg ccagagcttt gttttatata tttattcatc tgggaggcag aacaggcttc     2280

ggacagtgcc catgcaatgg cttgggttgg gattttggtt tcttcctttc ctcgtgaagg     2340

ataagagaaa caggcccggg gggaccagga tgacacctcc atttctctcc aggaagtttt     2400

gagtttctct ccaccgtgac acaatcctc                                       2429


<210>  7
<211>  2729
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  7
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gguccguggg       60

gcuggaagcu uagauggaca gucgcgcucc uccuugcagc agcaggaacu gcggucggag      120

aucgaugcga gcgcaacgag uuccaaugcc aagaugggaa guguauuucg uacaaguggg      180

ucugcgaugg aucagcggaa ugucaggacg gaagcgauga gagccaagaa acaugccucu      240

cagugacaug caagucggga gacuucucgu gcggaggacg cguaaacaga uguauuccac      300

aguuuuggcg cugcgauggu cagguggacu gcgacaacgg uucagaugaa cagggauguc      360

cuccgaaaac gugcucacaa gacgaguuuc gcugccauga uggaaagugc auuucgcggc      420

aguucguaug ugauucggau cgggacuguc uggacggcuc ggacgaagcg ucaugcccgg      480

uacuuacuug cgggccagcc ucauuccaau gcaacagcuc aacgugcauu ccccagcugu      540

gggccuguga caaugauccu gauugugagg acgguagcga cgaguggccg cagagaugua      600

gggguuugua cguauuccaa ggagacucaa gccccuguuc cgccuuugag uuucacugcc      660

ugucggguga augcauccac uccagcuggc gaugugaugg ugggcccgac ugcaaagaua      720

agagcgacga ggagaauugc gcggucgcga cgugcagacc cgaugaguuc cagugcuccg      780

auggaaacug cauccacggg agccggcagu gugaucgcga guacgauugu aaagacaugu      840

cagacgaggu cggaugcgug aacgucacgu ugugcgaggg uccgaacaag uuuaagugcc      900

auucgggcga auguauuacg cucgauaaag ucugcaacau ggcgcgagau uguagggauu      960

ggucagacga acccaucaag gagugcggca cuaacgagug uuuggacaau aacggcgggu     1020

guucgcacgu cugcaaugaa cucaaaauug gguaugagug ucucuguccu gacggauucc     1080

agcuggucgc gcagcgcaga ugcgaggaca ucgacgagug ccaggacccc gacacauguu     1140

cgcaguugug ugucaaccuu gaaggagggu acaagugcca gugcgaggag ggauuucagc     1200

uugacccgca cacgaaagca uguaaagcgg ugggguccau ugcguauuug uuuuucacaa     1260

acagacauga agugcggaag augacccuug aucgcagcga auauacguca cugaucccua     1320

aucuuaggaa ugucguggcc cuugacacgg agguagcauc aaauagaauc uacugguccg     1380

accucucaca gagaaugauc uguucaacac aguuggaucg ggcgcacggg gugucgucgu     1440

acgauacggu aauuagccgc gacauccagg cgccagacgg acucgcgguc gacuggaucc     1500

auagcaacau cuacuggaca gacuccgugu ugggaaccgu auccguagcu gacacaaagg     1560

gagugaagcg gaaaacucuu uuuagagaga acggcagcaa accgagagca aucguggucg     1620

auccggugca uggauucaug uauuggaccg auuggggaac gccagccaaa aucaagaaag     1680

gcgguuugaa uggggucgac aucuacucgc uggugacuga gaauauucag uggccaaacg     1740

ggaucaccuu ggacuuguug ucggggaggu uguauugggu ggacucaaag cuccacucga     1800

ucagcucgau cgacgugaac ggcggaaaua ggaaaacuau ucucgaagau gagaaaagac     1860

uggcccaccc cuucucgcuc gcgguguucg aggacaaagu auuuuggaca gacaucauca     1920

acgaagcgau cuuuucagcc aaccgccuga cagggucgga ugucaaucuc uuggccgaaa     1980

accuucugag cccggaagau auggucuugu uucacaauuu gacccaaccc agagguguga     2040

auuggugcga acggacgaca uugucgaacg gagguugcca guaucucugu cucccugcac     2100

cccagauuaa uccccauuca cccaaguuca cgugugcgug cccagacgga augcuucuug     2160

cgagggacau gagauccugu cucaccgaag cggaagcggc aguggccaca caagagacuu     2220

cgacuguccg ccuuaaagug uccucgacgg cgguccgaac ucagcauacg accacacgac     2280

ccgugcccga uaccucgcgg uugcccggag caacaccggg guugacgaca guagaaaucg     2340

uaaccaugag ccaccaggca cuuggagaug ucgcaggcag aggcaaugag aagaaaccca     2400

gcucggucag agcccucagc aucgugcugc cuauugugcu gcuuguguuu cucuguuugg     2460

guguguucuu guuguggaag aacuggcgcc uuaagaauau caacucgauu aacuucgaua     2520

auccgguaua ccagaaaacc acagaggaug aagugcauau uugucacaac caagauggcu     2580

auucguaccc guccaggcaa augguaucac uugaggacga cguggccuga uaauaggcug     2640

ccuucugcgg ggcuugccuu cuggccaugc ccuucuucuc ucccuugcac cuguaccucu     2700

uggucuuuga auaaagccug aguaggaag                                       2729


<210>  8
<211>  2729
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  8
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gguccguggg       60

gcuggaagcu uagauggaca gucgcgcucc uccuugcagc agcaggaacu gcggucggag      120

aucgaugcga gcgcaacgag uuccaaugcc aagaugggaa guguauuucg uacaaguggg      180

ucugcgaugg aucagcggaa ugucaggacg gaagcgauga gagccaagaa acaugccucu      240

cagugacaug caagucggga gacuucucgu gcggaggacg cguaaacaga uguauuccac      300

aguuuuggcg cugcgauggu cagguggacu gcgacaacgg uucagaugaa cagggauguc      360

cuccgaaaac gugcucacaa gacgaguuuc gcugccauga uggaaagugc auuucgcggc      420

aguucguaug ugauucggau cgggacuguc uggacggcuc ggacgaagcg ucaugcccgg      480

uacuuacuug cgggccagcc ucauuccaau gcaacagcuc aacgugcauu ccccagcugu      540

gggccuguga caaugauccu gauugugagg acgguagcga cgaguggccg cagagaugua      600

gggguuugua cguauuccaa ggagacucaa gccccuguuc cgccuuugag uuucacugcc      660

ugucggguga augcauccac uccagcuggc gaugugaugg ugggcccgac ugcaaagaua      720

agagcgacga ggagaauugc gcggucgcga cgugcagacc cgaugaguuc cagugcuccg      780

auggaaacug cauccacggg agccggcagu gugaucgcga guacgauugu aaagacaugu      840

cagacgaggu cggaugcgug aacgucacgu ugugcgaggg uccgaacaag uuuaagugcc      900

auucgggcga auguauuacg cucgauaaag ucugcaacau ggcgcgagau uguagggauu      960

ggucagacga acccaucaag gagugcggca cuaacgagug uuuggacaau aacggcgggu     1020

guucgcacgu cugcaaugau cucaaaauug gguaugagug ugauuguccu gacggauucc     1080

agcuggucgc gcagcgcaga ugcgaggaca ucgacgagug ccaggacccc gacacauguu     1140

cgcaguugug ugucaaccuu gaaggagggu acaagugcca gugcgaggag ggauuucagc     1200

uugacccgca cacgaaagca uguaaagcgg ugggguccau ugcguauuug uuuuucacaa     1260

acagacauga agugcggaag augacccuug aucgcagcga auauacguca cugaucccua     1320

aucuuaggaa ugucguggcc cuugacacgg agguagcauc aaauagaauc uacugguccg     1380

accucucaca gagaaugauc uguucaacac aguuggaucg ggcgcacggg gugucgucgu     1440

acgauacggu aauuagccgc gacauccagg cgccagacgg acucgcgguc gacuggaucc     1500

auagcaacau cuacuggaca gacuccgugu ugggaaccgu auccguagcu gacacaaagg     1560

gagugaagcg gaaaacucuu uuuagagaga acggcagcaa accgagagca aucguggucg     1620

auccggugca uggauucaug uauuggaccg auuggggaac gccagccaaa aucaagaaag     1680

gcgguuugaa uggggucgac aucuacucgc uggugacuga gaauauucag uggccaaacg     1740

ggaucaccuu ggacuuguug ucggggaggu uguauugggu ggacucaaag cuccacucga     1800

ucagcucgau cgacgugaac ggcggaaaua ggaaaacuau ucucgaagau gagaaaagac     1860

uggcccaccc cuucucgcuc gcgguguucg aggacaaagu auuuuggaca gacaucauca     1920

acgaagcgau cuuuucagcc aaccgccuga cagggucgga ugucaaucuc uuggccgaaa     1980

accuucugag cccggaagau auggucuugu uucacaauuu gacccaaccc agagguguga     2040

auuggugcga acggacgaca uugucgaacg gagguugcca guaucucugu cucccugcac     2100

cccagauuaa uccccauuca cccaaguuca cgugugcgug cccagacgga augcuucuug     2160

cgagggacau gagauccugu cucaccgaag cggaagcggc aguggccaca caagagacuu     2220

cgacuguccg ccuuaaagug uccucgacgg cgguccgaac ucagcauacg accacacgac     2280

ccgugcccga uaccucgcgg uugcccggag caacaccggg guugacgaca guagaaaucg     2340

uaaccaugag ccaccaggca cuuggagaug ucgcaggcag aggcaaugag aagaaaccca     2400

gcucggucag agcccucagc aucgugcugc cuauugugcu gcuuguguuu cucuguuugg     2460

guguguucuu guuguggaag aacuggcgcc uuaagaauau caacucgauu aacuucgaua     2520

auccgguaua ccagaaaacc acagaggaug aagugcauau uugucacaac caagauggcu     2580

auucguaccc guccaggcaa augguaucac uugaggacga cguggccuga uaauaggcug     2640

ccuucugcgg ggcuugccuu cuggccaugc ccuucuucuc ucccuugcac cuguaccucu     2700

uggucuuuga auaaagccug aguaggaag                                       2729


<210>  9
<211>  2729
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  9
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gguccguggg       60

gcuggaagcu uagauggaca gucgcgcucc uccuugcagc agcaggaacu gcggucggag      120

aucgaugcga gcgcaacgag uuccaaugcc aagaugggaa guguauuucg uacaaguggg      180

ucugcgaugg aucagcggaa ugucaggacg gaagcgauga gagccaagaa acaugccucu      240

cagugacaug caagucggga gacuucucgu gcggaggacg cguaaacaga uguauuccac      300

aguuuuggcg cugcgauggu cagguggacu gcgacaacgg uucagaugaa cagggauguc      360

cuccgaaaac gugcucacaa gacgaguuuc gcugccauga uggaaagugc auuucgcggc      420

aguucguaug ugauucggau cgggacuguc uggacggcuc ggacgaagcg ucaugcccgg      480

uacuuacuug cgggccagcc ucauuccaau gcaacagcuc aacgugcauu ccccagcugu      540

gggccuguga caaugauccu gauugugagg acgguagcga cgaguggccg cagagaugua      600

gggguuugua cguauuccaa ggagacucaa gccccuguuc cgccuuugag uuucacugcc      660

ugucggguga augcauccac uccagcuggc gaugugaugg ugggcccgac ugcaaagaua      720

agagcgacga ggagaauugc gcggucgcga cgugcagacc cgaugaguuc cagugcuccg      780

auggaaacug cauccacggg agccggcagu gugaucgcga guacgauugu aaagacaugu      840

cagacgaggu cggaugcgug aacgucacgu ugugcgaggg uccgaacaag uuuaagugcc      900

auucgggcga auguauuacg cucgauaaag ucugcaacau ggcgcgagau uguagggauu      960

ggucagacga acccaucaag gagugcggca cugcagagug uuuggacaau aacggcgggu     1020

guucgcacgu cugcaaugau cucaaaauug gguaugagug ucucuguccu gacggauucc     1080

agcuggucgc gcagcgcaga ugcgaggaca ucgacgagug ccaggacccc gacacauguu     1140

cgcaguugug ugucaaccuu gaaggagggu acaagugcca gugcgaggag ggauuucagc     1200

uugacccgca cacgaaagca uguaaagcgg ugggguccau ugcguauuug uuuuucacaa     1260

acagacauga agugcggaag augacccuug aucgcagcga auauacguca cugaucccua     1320

aucuuaggaa ugucguggcc cuugacacgg agguagcauc aaauagaauc uacugguccg     1380

accucucaca gagaaugauc uguucaacac aguuggaucg ggcgcacggg gugucgucgu     1440

acgauacggu aauuagccgc gacauccagg cgccagacgg acucgcgguc gacuggaucc     1500

auagcaacau cuacuggaca gacuccgugu ugggaaccgu auccguagcu gacacaaagg     1560

gagugaagcg gaaaacucuu uuuagagaga acggcagcaa accgagagca aucguggucg     1620

auccggugca uggauucaug uauuggaccg auuggggaac gccagccaaa aucaagaaag     1680

gcgguuugaa uggggucgac aucuacucgc uggugacuga gaauauucag uggccaaacg     1740

ggaucaccuu ggacuuguug ucggggaggu uguauugggu ggacucaaag cuccacucga     1800

ucagcucgau cgacgugaac ggcggaaaua ggaaaacuau ucucgaagau gagaaaagac     1860

uggcccaccc cuucucgcuc gcgguguucg aggacaaagu auuuuggaca gacaucauca     1920

acgaagcgau cuuuucagcc aaccgccuga cagggucgga ugucaaucuc uuggccgaaa     1980

accuucugag cccggaagau auggucuugu uucacaauuu gacccaaccc agagguguga     2040

auuggugcga acggacgaca uugucgaacg gagguugcca guaucucugu cucccugcac     2100

cccagauuaa uccccauuca cccaaguuca cgugugcgug cccagacgga augcuucuug     2160

cgagggacau gagauccugu cucaccgaag cggaagcggc aguggccaca caagagacuu     2220

cgacuguccg ccuuaaagug uccucgacgg cgguccgaac ucagcauacg accacacgac     2280

ccgugcccga uaccucgcgg uugcccggag caacaccggg guugacgaca guagaaaucg     2340

uaaccaugag ccaccaggca cuuggagaug ucgcaggcag aggcaaugag aagaaaccca     2400

gcucggucag agcccucagc aucgugcugc cuauugugcu gcuuguguuu cucuguuugg     2460

guguguucuu guuguggaag aacuggcgcc uuaagaauau caacucgauu aacuucgaua     2520

auccgguaua ccagaaaacc acagaggaug aagugcauau uugucacaac caagauggcu     2580

auucguaccc guccaggcaa augguaucac uugaggacga cguggccuga uaauaggcug     2640

ccuucugcgg ggcuugccuu cuggccaugc ccuucuucuc ucccuugcac cuguaccucu     2700

uggucuuuga auaaagccug aguaggaag                                       2729


<210>  10
<211>  2729
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  10
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gguccguggg       60

gcuggaagcu uagauggaca gucgcgcucc uccuugcagc agcaggaacu gcggucggag      120

aucgaugcga gcgcaacgag uuccaaugcc aagaugggaa guguauuucg uacaaguggg      180

ucugcgaugg aucagcggaa ugucaggacg gaagcgauga gagccaagaa acaugccucu      240

cagugacaug caagucggga gacuucucgu gcggaggacg cguaaacaga uguauuccac      300

aguuuuggcg cugcgauggu cagguggacu gcgacaacgg uucagaugaa cagggauguc      360

cuccgaaaac gugcucacaa gacgaguuuc gcugccauga uggaaagugc auuucgcggc      420

aguucguaug ugauucggau cgggacuguc uggacggcuc ggacgaagcg ucaugcccgg      480

uacuuacuug cgggccagcc ucauuccaau gcaacagcuc aacgugcauu ccccagcugu      540

gggccuguga caaugauccu gauugugagg acgguagcga cgaguggccg cagagaugua      600

gggguuugua cguauuccaa ggagacucaa gccccuguuc cgccuuugag uuucacugcc      660

ugucggguga augcauccac uccagcuggc gaugugaugg ugggcccgac ugcaaagaua      720

agagcgacga ggagaauugc gcggucgcga cgugcagacc cgaugaguuc cagugcuccg      780

auggaaacug cauccacggg agccggcagu gugaucgcga guacgauugu aaagacaugu      840

cagacgaggu cggaugcgug aacgucacgu ugugcgaggg uccgaacaag uuuaagugcc      900

auucgggcga auguauuacg cucgauaaag ucugcaacau ggcgcgagau uguagggauu      960

ggucagacga acccaucaag gagugcggca cuaacgcaug uuuggacaau aacggcgggu     1020

guucgcacgu cugcaaugau cucaaaauug gguaugagug ucucuguccu gacggauucc     1080

agcuggucgc gcagcgcaga ugcgaggaca ucgacgagug ccaggacccc gacacauguu     1140

cgcaguugug ugucaaccuu gaaggagggu acaagugcca gugcgaggag ggauuucagc     1200

uugacccgca cacgaaagca uguaaagcgg ugggguccau ugcguauuug uuuuucacaa     1260

acagacauga agugcggaag augacccuug aucgcagcga auauacguca cugaucccua     1320

aucuuaggaa ugucguggcc cuugacacgg agguagcauc aaauagaauc uacugguccg     1380

accucucaca gagaaugauc uguucaacac aguuggaucg ggcgcacggg gugucgucgu     1440

acgauacggu aauuagccgc gacauccagg cgccagacgg acucgcgguc gacuggaucc     1500

auagcaacau cuacuggaca gacuccgugu ugggaaccgu auccguagcu gacacaaagg     1560

gagugaagcg gaaaacucuu uuuagagaga acggcagcaa accgagagca aucguggucg     1620

auccggugca uggauucaug uauuggaccg auuggggaac gccagccaaa aucaagaaag     1680

gcgguuugaa uggggucgac aucuacucgc uggugacuga gaauauucag uggccaaacg     1740

ggaucaccuu ggacuuguug ucggggaggu uguauugggu ggacucaaag cuccacucga     1800

ucagcucgau cgacgugaac ggcggaaaua ggaaaacuau ucucgaagau gagaaaagac     1860

uggcccaccc cuucucgcuc gcgguguucg aggacaaagu auuuuggaca gacaucauca     1920

acgaagcgau cuuuucagcc aaccgccuga cagggucgga ugucaaucuc uuggccgaaa     1980

accuucugag cccggaagau auggucuugu uucacaauuu gacccaaccc agagguguga     2040

auuggugcga acggacgaca uugucgaacg gagguugcca guaucucugu cucccugcac     2100

cccagauuaa uccccauuca cccaaguuca cgugugcgug cccagacgga augcuucuug     2160

cgagggacau gagauccugu cucaccgaag cggaagcggc aguggccaca caagagacuu     2220

cgacuguccg ccuuaaagug uccucgacgg cgguccgaac ucagcauacg accacacgac     2280

ccgugcccga uaccucgcgg uugcccggag caacaccggg guugacgaca guagaaaucg     2340

uaaccaugag ccaccaggca cuuggagaug ucgcaggcag aggcaaugag aagaaaccca     2400

gcucggucag agcccucagc aucgugcugc cuauugugcu gcuuguguuu cucuguuugg     2460

guguguucuu guuguggaag aacuggcgcc uuaagaauau caacucgauu aacuucgaua     2520

auccgguaua ccagaaaacc acagaggaug aagugcauau uugucacaac caagauggcu     2580

auucguaccc guccaggcaa augguaucac uugaggacga cguggccuga uaauaggcug     2640

ccuucugcgg ggcuugccuu cuggccaugc ccuucuucuc ucccuugcac cuguaccucu     2700

uggucuuuga auaaagccug aguaggaag                                       2729


<210>  11
<211>  2729
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  11
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gguccguggg       60

gcuggaagcu uagauggaca gucgcgcucc uccuugcagc agcaggaacu gcggucggag      120

aucgaugcga gcgcaacgag uuccaaugcc aagaugggaa guguauuucg uacaaguggg      180

ucugcgaugg aucagcggaa ugucaggacg gaagcgauga gagccaagaa acaugccucu      240

cagugacaug caagucggga gacuucucgu gcggaggacg cguaaacaga uguauuccac      300

aguuuuggcg cugcgauggu cagguggacu gcgacaacgg uucagaugaa cagggauguc      360

cuccgaaaac gugcucacaa gacgaguuuc gcugccauga uggaaagugc auuucgcggc      420

aguucguaug ugauucggau cgggacuguc uggacggcuc ggacgaagcg ucaugcccgg      480

uacuuacuug cgggccagcc ucauuccaau gcaacagcuc aacgugcauu ccccagcugu      540

gggccuguga caaugauccu gauugugagg acgguagcga cgaguggccg cagagaugua      600

gggguuugua cguauuccaa ggagacucaa gccccuguuc cgccuuugag uuucacugcc      660

ugucggguga augcauccac uccagcuggc gaugugaugg ugggcccgac ugcaaagaua      720

agagcgacga ggagaauugc gcggucgcga cgugcagacc cgaugaguuc cagugcuccg      780

auggaaacug cauccacggg agccggcagu gugaucgcga guacgauugu aaagacaugu      840

cagacgaggu cggaugcgug aacgucacgu ugugcgaggg uccgaacaag uuuaagugcc      900

auucgggcga auguauuacg cucgauaaag ucugcaacau ggcgcgagau uguagggauu      960

ggucagacga acccaucaag gagugcggca cuaacgagug uuuggacaau aacggcgggu     1020

guucgcacgu cugcaaugau cucaaaauug gggcagagug ucucuguccu gacggauucc     1080

agcuggucgc gcagcgcaga ugcgaggaca ucgacgagug ccaggacccc gacacauguu     1140

cgcaguugug ugucaaccuu gaaggagggu acaagugcca gugcgaggag ggauuucagc     1200

uugacccgca cacgaaagca uguaaagcgg ugggguccau ugcguauuug uuuuucacaa     1260

acagacauga agugcggaag augacccuug aucgcagcga auauacguca cugaucccua     1320

aucuuaggaa ugucguggcc cuugacacgg agguagcauc aaauagaauc uacugguccg     1380

accucucaca gagaaugauc uguucaacac aguuggaucg ggcgcacggg gugucgucgu     1440

acgauacggu aauuagccgc gacauccagg cgccagacgg acucgcgguc gacuggaucc     1500

auagcaacau cuacuggaca gacuccgugu ugggaaccgu auccguagcu gacacaaagg     1560

gagugaagcg gaaaacucuu uuuagagaga acggcagcaa accgagagca aucguggucg     1620

auccggugca uggauucaug uauuggaccg auuggggaac gccagccaaa aucaagaaag     1680

gcgguuugaa uggggucgac aucuacucgc uggugacuga gaauauucag uggccaaacg     1740

ggaucaccuu ggacuuguug ucggggaggu uguauugggu ggacucaaag cuccacucga     1800

ucagcucgau cgacgugaac ggcggaaaua ggaaaacuau ucucgaagau gagaaaagac     1860

uggcccaccc cuucucgcuc gcgguguucg aggacaaagu auuuuggaca gacaucauca     1920

acgaagcgau cuuuucagcc aaccgccuga cagggucgga ugucaaucuc uuggccgaaa     1980

accuucugag cccggaagau auggucuugu uucacaauuu gacccaaccc agagguguga     2040

auuggugcga acggacgaca uugucgaacg gagguugcca guaucucugu cucccugcac     2100

cccagauuaa uccccauuca cccaaguuca cgugugcgug cccagacgga augcuucuug     2160

cgagggacau gagauccugu cucaccgaag cggaagcggc aguggccaca caagagacuu     2220

cgacuguccg ccuuaaagug uccucgacgg cgguccgaac ucagcauacg accacacgac     2280

ccgugcccga uaccucgcgg uugcccggag caacaccggg guugacgaca guagaaaucg     2340

uaaccaugag ccaccaggca cuuggagaug ucgcaggcag aggcaaugag aagaaaccca     2400

gcucggucag agcccucagc aucgugcugc cuauugugcu gcuuguguuu cucuguuugg     2460

guguguucuu guuguggaag aacuggcgcc uuaagaauau caacucgauu aacuucgaua     2520

auccgguaua ccagaaaacc acagaggaug aagugcauau uugucacaac caagauggcu     2580

auucguaccc guccaggcaa augguaucac uugaggacga cguggccuga uaauaggcug     2640

ccuucugcgg ggcuugccuu cuggccaugc ccuucuucuc ucccuugcac cuguaccucu     2700

uggucuuuga auaaagccug aguaggaag                                       2729


<210>  12
<211>  2729
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  12
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gguccguggg       60

gcuggaagcu uagauggaca gucgcgcucc uccuugcagc agcaggaacu gcggucggag      120

aucgaugcga gcgcaacgag uuccaaugcc aagaugggaa guguauuucg uacaaguggg      180

ucugcgaugg aucagcggaa ugucaggacg gaagcgauga gagccaagaa acaugccucu      240

cagugacaug caagucggga gacuucucgu gcggaggacg cguaaacaga uguauuccac      300

aguuuuggcg cugcgauggu cagguggacu gcgacaacgg uucagaugaa cagggauguc      360

cuccgaaaac gugcucacaa gacgaguuuc gcugccauga uggaaagugc auuucgcggc      420

aguucguaug ugauucggau cgggacuguc uggacggcuc ggacgaagcg ucaugcccgg      480

uacuuacuug cgggccagcc ucauuccaau gcaacagcuc aacgugcauu ccccagcugu      540

gggccuguga caaugauccu gauugugagg acgguagcga cgaguggccg cagagaugua      600

gggguuugua cguauuccaa ggagacucaa gccccuguuc cgccuuugag uuucacugcc      660

ugucggguga augcauccac uccagcuggc gaugugaugg ugggcccgac ugcaaagaua      720

agagcgacga ggagaauugc gcggucgcga cgugcagacc cgaugaguuc cagugcuccg      780

auggaaacug cauccacggg agccggcagu gugaucgcga guacgauugu aaagacaugu      840

cagacgaggu cggaugcgug aacgucacgu ugugcgaggg uccgaacaag uuuaagugcc      900

auucgggcga auguauuacg cucgauaaag ucugcaacau ggcgcgagau uguagggauu      960

ggucagacga acccaucaag gagugcggca cugcagcaug uuuggacaau aacggcgggu     1020

guucgcacgu cugcaaugca cucaaaauug gggcagagug ucucuguccu gacggauucc     1080

agcuggucgc gcagcgcaga ugcgaggaca ucgacgagug ccaggacccc gacacauguu     1140

cgcaguugug ugucaaccuu gaaggagggu acaagugcca gugcgaggag ggauuucagc     1200

uugacccgca cacgaaagca uguaaagcgg ugggguccau ugcguauuug uuuuucacaa     1260

acagacauga agugcggaag augacccuug aucgcagcga auauacguca cugaucccua     1320

aucuuaggaa ugucguggcc cuugacacgg agguagcauc aaauagaauc uacugguccg     1380

accucucaca gagaaugauc uguucaacac aguuggaucg ggcgcacggg gugucgucgu     1440

acgauacggu aauuagccgc gacauccagg cgccagacgg acucgcgguc gacuggaucc     1500

auagcaacau cuacuggaca gacuccgugu ugggaaccgu auccguagcu gacacaaagg     1560

gagugaagcg gaaaacucuu uuuagagaga acggcagcaa accgagagca aucguggucg     1620

auccggugca uggauucaug uauuggaccg auuggggaac gccagccaaa aucaagaaag     1680

gcgguuugaa uggggucgac aucuacucgc uggugacuga gaauauucag uggccaaacg     1740

ggaucaccuu ggacuuguug ucggggaggu uguauugggu ggacucaaag cuccacucga     1800

ucagcucgau cgacgugaac ggcggaaaua ggaaaacuau ucucgaagau gagaaaagac     1860

uggcccaccc cuucucgcuc gcgguguucg aggacaaagu auuuuggaca gacaucauca     1920

acgaagcgau cuuuucagcc aaccgccuga cagggucgga ugucaaucuc uuggccgaaa     1980

accuucugag cccggaagau auggucuugu uucacaauuu gacccaaccc agagguguga     2040

auuggugcga acggacgaca uugucgaacg gagguugcca guaucucugu cucccugcac     2100

cccagauuaa uccccauuca cccaaguuca cgugugcgug cccagacgga augcuucuug     2160

cgagggacau gagauccugu cucaccgaag cggaagcggc aguggccaca caagagacuu     2220

cgacuguccg ccuuaaagug uccucgacgg cgguccgaac ucagcauacg accacacgac     2280

ccgugcccga uaccucgcgg uugcccggag caacaccggg guugacgaca guagaaaucg     2340

uaaccaugag ccaccaggca cuuggagaug ucgcaggcag aggcaaugag aagaaaccca     2400

gcucggucag agcccucagc aucgugcugc cuauugugcu gcuuguguuu cucuguuugg     2460

guguguucuu guuguggaag aacuggcgcc uuaagaauau caacucgauu aacuucgaua     2520

auccgguaua ccagaaaacc acagaggaug aagugcauau uugucacaac caagauggcu     2580

auucguaccc guccaggcaa augguaucac uugaggacga cguggccuga uaauaggcug     2640

ccuucugcgg ggcuugccuu cuggccaugc ccuucuucuc ucccuugcac cuguaccucu     2700

uggucuuuga auaaagccug aguaggaag                                       2729


<210>  13
<211>  1678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  13
gggaaataag agagaaaaga agagtaagaa gaaatataag agccaccatg atgaccacat       60

ctttgatttg ggggattgct atagcagcat gctgttgtct atggcttatt cttggaatta      120

ggagaaggca aacgggtgaa ccacctcttg agaatggatt aattccatac ctgggctgtg      180

ctctgcaatt tggtgccaat cctcttgagt tcctcagagc aaatcaaagg aaacatggtc      240

atgtttttac ctgcaaacta atgggaaaat atgtccattt catcacaaat cccttgtcat      300

accataaggt gttgtgccac ggaaaatatt ttgattggaa aaaatttcac tttgctactt      360

ctgcgaaggc atttgggcac agaagcattg acccgatgga tggaaatacc actgaaaaca      420

taaacgacac tttcatcaaa accctgcagg gccatgcctt gaattccctc acggaaagca      480

tgatggaaaa cctccaacgt atcatgagac ctccagtctc ctctaactca aagaccgctg      540

cctgggtgac agaagggatg tattctttct gctaccgagt gatgtttgaa gctgggtatt      600

taactatctt tggcagagat cttacaaggc gggacacaca gaaagcacat attctaaaca      660

atcttgacaa cttcaagcaa ttcgacaaag tctttccagc cctggtagca ggcctcccca      720

ttcacatgtt caggactgcg cacaatgccc gggagaaact ggcagagagc ttgaggcacg      780

agaacctcca aaagagggaa agcatctcag aactgatcag cctgcgcatg tttctcaatg      840

acactttgtc cacctttgat gatctggaga aggccaagac acacctcgtg gtcctctggg      900

catcgcaagc aaacaccatt ccagcgactt tctggagttt atttcaaatg attaggaacc      960

cagaagcaat gaaagcagct actgaagaag tgaaaagaac attagagaat gctggtcaaa     1020

aagtcagctt ggaaggcaat cctatttgtt tgagtcaagc agaactgaat gacctgccag     1080

tattagatag tataatcaag gaatcgctga ggctttccag tgcctccctc aacatccgga     1140

cagctaagga ggatttcact ttgcaccttg aggacggttc ctacaacatc cgaaaagatg     1200

acatcatagc tctttaccca cagttaatgc acttagatcc agaaatctac ccagaccctt     1260

tgacttttaa atatgatagg tatcttgatg aaaacgggaa gacaaagact accttctatt     1320

gtaatggact caagttaaag tattactaca tgccctttgg atcgggagct acaatatgtc     1380

ctggaagatt gttcgctatc cacgaaatca agcaattttt gattctgatg ctttcttatt     1440

ttgaattgga gcttatagag ggccaagcta aatgtccacc tttggaccag tcccgggcag     1500

gcttgggcat tttgccgcca ttgaatgata ttgaatttaa atataaattc aagcatttgt     1560

gataataggc tggagcctcg gtggccatgc ttcttgcccc ttgggcctcc ccccagcccc     1620

tcctcccctt cctgcacccg tacccccgtg gtctttgaat aaagtctgag tgggcggc       1678


<210>  14
<211>  1541
<212>  DNA
<213>  Homo sapiens

<400>  14
agtggggagc acggtggaga gcggggacgg ccggctcttt ggggacttgc tggggcgtgc       60

ggctgcgcta ttcagtggga aggttcgcgg ggttgggaga cccggaggcc gaggaagggc      120

gagcagagca ctgccaggat atcctgccca gatttcccag tttctgcctc gccgcggcac      180

agacggaggc agcctggtgg aggtgtatct cctagacacc agcatacaga gtgaccaccg      240

ggaaatcgag ggcagggtca tggtcaccga cttcgagaat gtgcccgagg aggacgggac      300

ccgcttccac agacaggcca gcaagtgtga cagtcatggc acccacctgg caggggtggt      360

cagcggccgg gatgccggcg tggccaaggg tgccagcatg cgcagcctgc gcgtgctcaa      420

ctgccaaggg aagggcacgg ttagcggcac cctcataggc ctggagttta ttcggaaaag      480

ccagctggtc cagcctgtgg ggccactggt ggtgctgctg cccctggcgg gtgggtacag      540

ccgcgtcctc aacgccgcct gccagcgcct ggcgagggct ggggtcgtgc tggtcaccgc      600

tgccggcaac ttccgggacg atgcctgcct ctactcccca gcctcagctc ccgaggtcat      660

cacagttggg gccaccaatg cccaagacca gccggtgacc ctggggactt tggggaccaa      720

ctttggccgc tgtgtggacc tctttgcccc aggggaggac atcattggtg cctccagcga      780

ctgcagcacc tgctttgtgt cacagagtgg gacatcacag gctgctgccc acgtggctgg      840

cattgcagcc atgatgctgt ctgccgagcc ggagctcacc ctggccgagt tgaggcagag      900

actgatccac ttctctgcca aagatgtcat caatgaggcc tggttccctg aggaccagcg      960

ggttggcagc tgttttgcag gactgtatgg tcagcacact cggggcctac acggatggcc     1020

acagccgtcg cccgctgcgc cccagatgag gagctgctga gctgctccag tttctccagg     1080

agtgggaagc ggcggggcga gcgcatggag gcccaagggg gcaagctggt ctgccgggcc     1140

cacaacgctt ttgggggtga gggtgtctac gccattgcca ggtgctgcct gctaccccag     1200

gccaactgca gcgtccacac agctccacca gctgaggcca gcatggggac ccgtgtccac     1260

tgccaccaac agggccacgt cctcacaggc tgcagctccc actgggaggt ggaggacctt     1320

ggcacccaca agccgcctgt gctgaggcca cgaggtcagc ccaaccagtg cgtgggccac     1380

agggaggcca gcatccacgc ttcctgctgc catgccccag gtctggaatg caaagtcaag     1440

gagcatggaa tcccggcccc tcaggagcag gtgaccgtgg cctgcgagga gggctggacc     1500

ctgactggct gcagtgccct ccctgggacc tcccacgtcc t                         1541


<210>  15
<211>  1101
<212>  DNA
<213>  Homo sapiens

<400>  15
aggctcaagg cgccgccggc gtggaccgcg cacggcctct aggtctcctc gccaggacag       60

caacctctcc cctggccctc atgggcaccg tcagctccag gcggtcctgg tggccgctgc      120

cactgctgct gctgctgctg ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg      180

aggacggcga ctacgaggag ctggtgctag ccttgcgttc cgaggaggac ggcctggccg      240

aagcacccga gcacggaacc acagccacct tccaccgctg cgccaaggat ccgtggaggt      300

tgcctggcac ctacgtggtg gtgctgaagg aggagaccca cctctcgcag tcagagcgca      360

ctgcccgccg cctgcaggcc caggctgccc gccggggata cctcaccaag atcctgcatg      420

tcttccatgg ccttcttcct ggcttcctgg tgaagatgag tggcgacctg ctggagctgg      480

ccttgaagtt gccccatgtc gactacatcg aggaggactc ctctgtcttt gcccagagca      540

tcccgtggaa cctggagcgg attacccctc cacggtaccg ggcggatgaa taccagcccc      600

ccgcatattt ggaggatcac tgcgggggcc acagaggtgc tgttcagatg gcacttcaga      660

agactcagga gaccctgggg caggagcagt ttgactgaca gcccagaggg ctgccctctg      720

attccacctg aggccctgct tttcctggct gcaggggttc cagggccagg ccatttccgc      780

tggcgcagga ctctgctagc agcaacctgc ctgaagtctt cctttggcct ggctgagagt      840

ttctgagacc tgcgctggag cggagacgga ggcagcctgg tggaggtgta tctcctagac      900

accagcatac agagtgacca ccgggaaatc gagggcaggg tcatggtcac cgacttcgag      960

aatgtgcccg aggaggacgg gacccgcttc cacagacagg ccagcaagtg tgacagtcat     1020

ggcacccacc tggcaggggt ggtcagcggc cgggatgccg gcgtggccaa gggtgccagc     1080

atgcgcagcc tgcgcgtgct c                                               1101


<210>  16
<211>  3637
<212>  DNA
<213>  Homo sapiens

<400>  16
agcgacgtcg aggcgctcat ggttgcaggc gggcgccgcc gttcagttca gggtctgagc       60

ctggaggagt gagccaggca gtgagactgg ctcgggcggg ccgggacgcg tcgttgcagc      120

agcggctccc agctcccagc caggattccg cgcgcccctt cacgcgccct gctcctgaac      180

ttcagctcct gcacagtcct ccccaccgca aggctcaagg cgccgccggc gtggaccgcg      240

cacggcctct aggtctcctc gccaggacag caacctctcc cctggccctc atgggcaccg      300

tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg ctgctcctgg      360

gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag ctggtgctag      420

ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc acagccacct      480

tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg gtgctgaagg      540

aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc caggctgccc      600

gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct ggcttcctgg      660

tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc gactacatcg      720

aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg attacccctc      780

cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg gaggtgtatc      840

tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc atggtcaccg      900

acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc agcaagtgtg      960

acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc gtggccaagg     1020

gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg gttagcggca     1080

ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg gggccactgg     1140

tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc tgccagcgcc     1200

tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac gatgcctgcc     1260

tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat gcccaagacc     1320

agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac ctctttgccc     1380

caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg tcacagagtg     1440

ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg tctgccgagc     1500

cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc aaagatgtca     1560

tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg gtggccgccc     1620

tgccccccag cacccatggg gcaggttggc agctgttttg caggactgta tggtcagcac     1680

actcggggcc tacacggatg gccacagccg tcgcccgctg cgccccagat gaggagctgc     1740

tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg gaggcccaag     1800

ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc tacgccattg     1860

ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca ccagctgagg     1920

ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca ggctgcagct     1980

cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg ccacgaggtc     2040

agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc tgccatgccc     2100

caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag caggtgaccg     2160

tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg acctcccacg     2220

tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac gtcagcacta     2280

caggcagcac cagcgaaggg gccgtgacag ccgttgccat ctgctgccgg agccggcacc     2340

tggcgcaggc ctcccaggag ctccagtgac agccccatcc caggatgggt gtctggggag     2400

ggtcaagggc tggggctgag ctttaaaatg gttccgactt gtccctctct cagccctcca     2460

tggcctggca cgaggggatg gggatgcttc cgcctttccg gggctgctgg cctggccctt     2520

gagtggggca gcctccttgc ctggaactca ctcactctgg gtgcctcctc cccaggtgga     2580

ggtgccagga agctccctcc ctcactgtgg ggcatttcac cattcaaaca ggtcgagctg     2640

tgctcgggtg ctgccagctg ctcccaatgt gccgatgtcc gtgggcagaa tgacttttat     2700

tgagctcttg ttccgtgcca ggcattcaat cctcaggtct ccaccaagga ggcaggattc     2760

ttcccatgga taggggaggg ggcggtaggg gctgcaggga caaacatcgt tggggggtga     2820

gtgtgaaagg tgctgatggc cctcatctcc agctaactgt ggagaagccc ctgggggctc     2880

cctgattaat ggaggcttag ctttctggat ggcatctagc cagaggctgg agacaggtgc     2940

gcccctggtg gtcacaggct gtgccttggt ttcctgagcc acctttactc tgctctatgc     3000

caggctgtgc tagcaacacc caaaggtggc ctgcggggag ccatcaccta ggactgactc     3060

ggcagtgtgc agtggtgcat gcactgtctc agccaacccg ctccactacc cggcagggta     3120

cacattcgca cccctacttc acagaggaag aaacctggaa ccagaggggg cgtgcctgcc     3180

aagctcacac agcaggaact gagccagaaa cgcagattgg gctggctctg aagccaagcc     3240

tcttcttact tcacccggct gggctcctca tttttacggg taacagtgag gctgggaagg     3300

ggaacacaga ccaggaagct cggtgagtga tggcagaacg atgcctgcag gcatggaact     3360

ttttccgtta tcacccaggc ctgattcact ggcctggcgg agatgcttct aaggcatggt     3420

cgggggagag ggccaacaac tgtccctcct tgagcaccag ccccacccaa gcaagcagac     3480

atttatcttt tgggtctgtc ctctctgttg cctttttaca gccaactttt ctagacctgt     3540

tttgcttttg taacttgaag atatttattc tgggttttgt agcattttta ttaatatggt     3600

gactttttaa aataaaaaca aacaaacgtt gtcctaa                              3637


<210>  17
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Leu Thr Leu Cys Glu Gly Pro Asn 
            100                 105                 110         


Lys Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val Cys 
        115                 120                 125             


Asn Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys Glu 
    130                 135                 140                 


Cys Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val 
145                 150                 155                 160 


Cys Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe 
                165                 170                 175     


Gln Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln Asp 
            180                 185                 190         


Pro Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys 
        195                 200                 205             


Cys Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala Cys 
    210                 215                 220                 


Lys Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His Glu 
225                 230                 235                 240 


Val Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro 
                245                 250                 255     


Asn Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg 
            260                 265                 270         


Ile Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln Leu 
        275                 280                 285             


Asp Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp 
    290                 295                 300                 


Ile Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn Ile 
305                 310                 315                 320 


Tyr Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr Lys 
                325                 330                 335     


Gly Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg 
            340                 345                 350         


Ala Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp Trp 
        355                 360                 365             


Gly Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp Ile 
    370                 375                 380                 


Tyr Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu 
385                 390                 395                 400 


Asp Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His Ser 
                405                 410                 415     


Ile Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu Glu 
            420                 425                 430         


Asp Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu Asp 
        435                 440                 445             


Lys Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala Asn 
    450                 455                 460                 


Arg Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu Ser 
465                 470                 475                 480 


Pro Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly Val 
                485                 490                 495     


Asn Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr Leu 
            500                 505                 510         


Cys Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro Lys Phe Thr Cys 
        515                 520                 525             


Ala Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys Leu 
    530                 535                 540                 


Thr Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val Arg 
545                 550                 555                 560 


Leu Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr Arg 
                565                 570                 575     


Pro Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu Thr 
            580                 585                 590         


Thr Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val Ala 
        595                 600                 605             


Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser Ile 
    610                 615                 620                 


Val Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe Leu 
625                 630                 635                 640 


Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp 
                645                 650                 655     


Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys His 
            660                 665                 670         


Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu Glu 
        675                 680                 685             


Asp Asp Val Ala 
    690         


<210>  18
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Asp Phe 
            20                  25                  30          


Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp Ala Cys Asp Asn 
        35                  40                  45              


Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro Gln Arg Cys Arg 
    50                  55                  60                  


Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys Ser Ala Phe Glu 
65                  70                  75                  80  


Phe His Cys Leu Ser Gly Glu Cys Ile His Ser Ser Trp Arg Cys Asp 
                85                  90                  95      


Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu Asn Cys Ala Val 
            100                 105                 110         


Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile 
        115                 120                 125             


His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser 
    130                 135                 140                 


Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu Gly Pro Asn Lys 
145                 150                 155                 160 


Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val Cys Asn 
                165                 170                 175     


Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys 
            180                 185                 190         


Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys 
        195                 200                 205             


Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln 
    210                 215                 220                 


Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro 
225                 230                 235                 240 


Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys 
                245                 250                 255     


Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala Cys Lys 
            260                 265                 270         


Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His Glu Val 
        275                 280                 285             


Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn 
    290                 295                 300                 


Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg Ile 
305                 310                 315                 320 


Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln Leu Asp 
                325                 330                 335     


Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile 
            340                 345                 350         


Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn Ile Tyr 
        355                 360                 365             


Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr Lys Gly 
    370                 375                 380                 


Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala 
385                 390                 395                 400 


Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp Trp Gly 
                405                 410                 415     


Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr 
            420                 425                 430         


Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        435                 440                 445             


Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His Ser Ile 
    450                 455                 460                 


Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp 
465                 470                 475                 480 


Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu Asp Lys 
                485                 490                 495     


Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg 
            500                 505                 510         


Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro 
        515                 520                 525             


Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly Val Asn 
    530                 535                 540                 


Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr Leu Cys 
545                 550                 555                 560 


Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro Lys Phe Thr Cys Ala 
                565                 570                 575     


Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys Leu Thr 
            580                 585                 590         


Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val Arg Leu 
        595                 600                 605             


Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr Arg Pro 
    610                 615                 620                 


Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu Thr Thr 
625                 630                 635                 640 


Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val Ala Gly 
                645                 650                 655     


Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser Ile Val 
            660                 665                 670         


Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe Leu Leu 
        675                 680                 685             


Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp Asn 
    690                 695                 700                 


Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys His Asn 
705                 710                 715                 720 


Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp 
                725                 730                 735     


Asp Val Ala 
            


<210>  19
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  20
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855             


<210>  21
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Ser 
    50                  55                  60                  


Pro Lys Thr Cys Ser Gln Asp Glu Phe Arg Cys His Asp Gly Lys Cys 
65                  70                  75                  80  


Ile Ser Arg Gln Phe Val Cys Asp Ser Asp Arg Asp Cys Leu Asp Gly 
                85                  90                  95      


Ser Asp Glu Ala Ser Cys Pro Val Leu Thr Cys Gly Pro Ala Ser Phe 
            100                 105                 110         


Gln Cys Asn Ser Ser Thr Cys Ile Pro Gln Leu Trp Ala Cys Asp Asn 
        115                 120                 125             


Asp Pro Asp Cys Glu Asp Gly Ser Asp Glu Trp Pro Gln Arg Cys Arg 
    130                 135                 140                 


Gly Leu Tyr Val Phe Gln Gly Asp Ser Ser Pro Cys Ser Ala Phe Glu 
145                 150                 155                 160 


Phe His Cys Leu Ser Gly Glu Cys Ile His Ser Ser Trp Arg Cys Asp 
                165                 170                 175     


Gly Gly Pro Asp Cys Lys Asp Lys Ser Asp Glu Glu Asn Cys Ala Val 
            180                 185                 190         


Ala Thr Cys Arg Pro Asp Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile 
        195                 200                 205             


His Gly Ser Arg Gln Cys Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser 
    210                 215                 220                 


Asp Glu Val Gly Cys Val Asn Val Thr Leu Cys Glu Gly Pro Asn Lys 
225                 230                 235                 240 


Phe Lys Cys His Ser Gly Glu Cys Ile Thr Leu Asp Lys Val Cys Asn 
                245                 250                 255     


Met Ala Arg Asp Cys Arg Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys 
            260                 265                 270         


Gly Thr Asn Glu Cys Leu Asp Asn Asn Gly Gly Cys Ser His Val Cys 
        275                 280                 285             


Asn Asp Leu Lys Ile Gly Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln 
    290                 295                 300                 


Leu Val Ala Gln Arg Arg Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro 
305                 310                 315                 320 


Asp Thr Cys Ser Gln Leu Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys 
                325                 330                 335     


Gln Cys Glu Glu Gly Phe Gln Leu Asp Pro His Thr Lys Ala Cys Lys 
            340                 345                 350         


Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg His Glu Val 
        355                 360                 365             


Arg Lys Met Thr Leu Asp Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn 
    370                 375                 380                 


Leu Arg Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg Ile 
385                 390                 395                 400 


Tyr Trp Ser Asp Leu Ser Gln Arg Met Ile Cys Ser Thr Gln Leu Asp 
                405                 410                 415     


Arg Ala His Gly Val Ser Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile 
            420                 425                 430         


Gln Ala Pro Asp Gly Leu Ala Val Asp Trp Ile His Ser Asn Ile Tyr 
        435                 440                 445             


Trp Thr Asp Ser Val Leu Gly Thr Val Ser Val Ala Asp Thr Lys Gly 
    450                 455                 460                 


Val Lys Arg Lys Thr Leu Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala 
465                 470                 475                 480 


Ile Val Val Asp Pro Val His Gly Phe Met Tyr Trp Thr Asp Trp Gly 
                485                 490                 495     


Thr Pro Ala Lys Ile Lys Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr 
            500                 505                 510         


Ser Leu Val Thr Glu Asn Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        515                 520                 525             


Leu Leu Ser Gly Arg Leu Tyr Trp Val Asp Ser Lys Leu His Ser Ile 
    530                 535                 540                 


Ser Ser Ile Asp Val Asn Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp 
545                 550                 555                 560 


Glu Lys Arg Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu Asp Lys 
                565                 570                 575     


Val Phe Trp Thr Asp Ile Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg 
            580                 585                 590         


Leu Thr Gly Ser Asp Val Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro 
        595                 600                 605             


Glu Asp Met Val Leu Phe His Asn Leu Thr Gln Pro Arg Gly Val Asn 
    610                 615                 620                 


Trp Cys Glu Arg Thr Thr Leu Ser Asn Gly Gly Cys Gln Tyr Leu Cys 
625                 630                 635                 640 


Leu Pro Ala Pro Gln Ile Asn Pro His Ser Pro Lys Phe Thr Cys Ala 
                645                 650                 655     


Cys Pro Asp Gly Met Leu Leu Ala Arg Asp Met Arg Ser Cys Leu Thr 
            660                 665                 670         


Glu Ala Glu Ala Ala Val Ala Thr Gln Glu Thr Ser Thr Val Arg Leu 
        675                 680                 685             


Lys Val Ser Ser Thr Ala Val Arg Thr Gln His Thr Thr Thr Arg Pro 
    690                 695                 700                 


Val Pro Asp Thr Ser Arg Leu Pro Gly Ala Thr Pro Gly Leu Thr Thr 
705                 710                 715                 720 


Val Glu Ile Val Thr Met Ser His Gln Ala Leu Gly Asp Val Ala Gly 
                725                 730                 735     


Arg Gly Asn Glu Lys Lys Pro Ser Ser Val Arg Ala Leu Ser Ile Val 
            740                 745                 750         


Leu Pro Ile Val Leu Leu Val Phe Leu Cys Leu Gly Val Phe Leu Leu 
        755                 760                 765             


Trp Lys Asn Trp Arg Leu Lys Asn Ile Asn Ser Ile Asn Phe Asp Asn 
    770                 775                 780                 


Pro Val Tyr Gln Lys Thr Thr Glu Asp Glu Val His Ile Cys His Asn 
785                 790                 795                 800 


Gln Asp Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp 
                805                 810                 815     


Asp Val Ala 
            


<210>  22
<211>  682
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Val Ala Thr Cys Arg Pro Asp 
            100                 105                 110         


Glu Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys 
        115                 120                 125             


Asp Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val 
    130                 135                 140                 


Asn Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly 
145                 150                 155                 160 


Glu Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg 
                165                 170                 175     


Asp Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu 
            180                 185                 190         


Asp Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly 
        195                 200                 205             


Tyr Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg 
    210                 215                 220                 


Cys Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu 
225                 230                 235                 240 


Cys Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe 
                245                 250                 255     


Gln Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala 
            260                 265                 270         


Tyr Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp 
        275                 280                 285             


Arg Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala 
    290                 295                 300                 


Leu Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser 
305                 310                 315                 320 


Gln Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser 
                325                 330                 335     


Ser Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu 
            340                 345                 350         


Ala Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu 
        355                 360                 365             


Gly Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu 
    370                 375                 380                 


Phe Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val 
385                 390                 395                 400 


His Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys 
                405                 410                 415     


Lys Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn 
            420                 425                 430         


Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu 
        435                 440                 445             


Tyr Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn 
    450                 455                 460                 


Gly Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His 
465                 470                 475                 480 


Pro Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile 
                485                 490                 495     


Ile Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val 
            500                 505                 510         


Asn Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe 
        515                 520                 525             


His Asn Leu Thr Gln Pro Arg Glu Ala Glu Ala Ala Val Ala Thr Gln 
    530                 535                 540                 


Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val Arg Thr 
545                 550                 555                 560 


Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu Pro Gly 
                565                 570                 575     


Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser His Gln 
            580                 585                 590         


Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro Ser Ser 
        595                 600                 605             


Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val Phe Leu 
    610                 615                 620                 


Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys Asn Ile 
625                 630                 635                 640 


Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr Glu Asp 
                645                 650                 655     


Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg 
            660                 665                 670         


Gln Met Val Ser Leu Glu Asp Asp Val Ala 
        675                 680         


<210>  23
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Met Thr Thr Ser Leu Ile Trp Gly Ile Ala Ile Ala Ala Cys Cys 
1               5                   10                  15      


Cys Leu Trp Leu Ile Leu Gly Ile Arg Arg Arg Gln Thr Gly Glu Pro 
            20                  25                  30          


Pro Leu Glu Asn Gly Leu Ile Pro Tyr Leu Gly Cys Ala Leu Gln Phe 
        35                  40                  45              


Gly Ala Asn Pro Leu Glu Phe Leu Arg Ala Asn Gln Arg Lys His Gly 
    50                  55                  60                  


His Val Phe Thr Cys Lys Leu Met Gly Lys Tyr Val His Phe Ile Thr 
65                  70                  75                  80  


Asn Pro Leu Ser Tyr His Lys Val Leu Cys His Gly Lys Tyr Phe Asp 
                85                  90                  95      


Trp Lys Lys Phe His Phe Ala Thr Ser Ala Lys Ala Phe Gly His Arg 
            100                 105                 110         


Ser Ile Asp Pro Met Asp Gly Asn Thr Thr Glu Asn Ile Asn Asp Thr 
        115                 120                 125             


Phe Ile Lys Thr Leu Gln Gly His Ala Leu Asn Ser Leu Thr Glu Ser 
    130                 135                 140                 


Met Met Glu Asn Leu Gln Arg Ile Met Arg Pro Pro Val Ser Ser Asn 
145                 150                 155                 160 


Ser Lys Thr Ala Ala Trp Val Thr Glu Gly Met Tyr Ser Phe Cys Tyr 
                165                 170                 175     


Arg Val Met Phe Glu Ala Gly Tyr Leu Thr Ile Phe Gly Arg Asp Leu 
            180                 185                 190         


Thr Arg Arg Asp Thr Gln Lys Ala His Ile Leu Asn Asn Leu Asp Asn 
        195                 200                 205             


Phe Lys Gln Phe Asp Lys Val Phe Pro Ala Leu Val Ala Gly Leu Pro 
    210                 215                 220                 


Ile His Met Phe Arg Thr Ala His Asn Ala Arg Glu Lys Leu Ala Glu 
225                 230                 235                 240 


Ser Leu Arg His Glu Asn Leu Gln Lys Arg Glu Ser Ile Ser Glu Leu 
                245                 250                 255     


Ile Ser Leu Arg Met Phe Leu Asn Asp Thr Leu Ser Thr Phe Asp Asp 
            260                 265                 270         


Leu Glu Lys Ala Lys Thr His Leu Val Val Leu Trp Ala Ser Gln Ala 
        275                 280                 285             


Asn Thr Ile Pro Ala Thr Phe Trp Ser Leu Phe Gln Met Ile Arg Asn 
    290                 295                 300                 


Pro Glu Ala Met Lys Ala Ala Thr Glu Glu Val Lys Arg Thr Leu Glu 
305                 310                 315                 320 


Asn Ala Gly Gln Lys Val Ser Leu Glu Gly Asn Pro Ile Cys Leu Ser 
                325                 330                 335     


Gln Ala Glu Leu Asn Asp Leu Pro Val Leu Asp Ser Ile Ile Lys Glu 
            340                 345                 350         


Ser Leu Arg Leu Ser Ser Ala Ser Leu Asn Ile Arg Thr Ala Lys Glu 
        355                 360                 365             


Asp Phe Thr Leu His Leu Glu Asp Gly Ser Tyr Asn Ile Arg Lys Asp 
    370                 375                 380                 


Asp Ile Ile Ala Leu Tyr Pro Gln Leu Met His Leu Asp Pro Glu Ile 
385                 390                 395                 400 


Tyr Pro Asp Pro Leu Thr Phe Lys Tyr Asp Arg Tyr Leu Asp Glu Asn 
                405                 410                 415     


Gly Lys Thr Lys Thr Thr Phe Tyr Cys Asn Gly Leu Lys Leu Lys Tyr 
            420                 425                 430         


Tyr Tyr Met Pro Phe Gly Ser Gly Ala Thr Ile Cys Pro Gly Arg Leu 
        435                 440                 445             


Phe Ala Ile His Glu Ile Lys Gln Phe Leu Ile Leu Met Leu Ser Tyr 
    450                 455                 460                 


Phe Glu Leu Glu Leu Ile Glu Gly Gln Ala Lys Cys Pro Pro Leu Asp 
465                 470                 475                 480 


Gln Ser Arg Ala Gly Leu Gly Ile Leu Pro Pro Leu Asn Asp Ile Glu 
                485                 490                 495     


Phe Lys Tyr Lys Phe Lys His Leu 
            500                 


<210>  24
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe 
1               5                   10                  15      


His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly 
            20                  25                  30          


Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg 
        35                  40                  45              


Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr 
    50                  55                  60                  


Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val 
65                  70                  75                  80  


Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val 
                85                  90                  95      


Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val 
            100                 105                 110         


Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala 
        115                 120                 125             


Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln 
    130                 135                 140                 


Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp 
145                 150                 155                 160 


Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser 
                165                 170                 175     


Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val 
            180                 185                 190         


Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu 
        195                 200                 205             


Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile 
    210                 215                 220                 


Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Gly Ser Cys Phe Ala 
225                 230                 235                 240 


Gly Leu Tyr Gly Gln His Thr Arg Gly Leu His Gly Trp Pro Gln Pro 
                245                 250                 255     


Ser Pro Ala Ala Pro Gln Met Arg Ser Cys 
            260                 265     


<210>  25
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Ala Tyr 
                165                 170                 175     


Leu Glu Asp His Cys Gly Gly His Arg Gly Ala Val Gln Met Ala Leu 
            180                 185                 190         


Gln Lys Thr Gln Glu Thr Leu Gly Gln Glu Gln Phe Asp 
        195                 200                 205 


<210>  26
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  27
<211>  615
<212>  DNA
<213>  Homo sapiens

<400>  27
atggctggac ctgccaccca gagccccatg aagctgatgg ccctgcagct gctgctgtgg       60

cacagtgcac tctggacagt gcaggaagcc acccccctgg gccctgccag ctccctgccc      120

cagagcttcc tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg      180

ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc      240

ggacactctc tgggcatccc ctgggctccc ctgagcagct gccccagcca ggccctgcag      300

ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag      360

gccctggaag ggatctcccc cgagttgggt cccaccttgg acacactgca gctggacgtc      420

gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg      480

cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg      540

gtcctggttg cctcccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac      600

cttgcccagc cctga                                                       615


<210>  28
<211>  800
<212>  DNA
<213>  Homo sapiens

<400>  28
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatggct ggacctgcca cccagagccc catgaagctg atggccctgc agctgctgct      120

gtggcacagt gcactctgga cagtgcagga agccaccccc ctgggccctg ccagctccct      180

gccccagagc ttcctgctca agtgcttaga gcaagtgagg aagatccagg gcgatggcgc      240

agcgctccag gagaagctgt gtgccaccta caagctgtgc caccccgagg agctggtgct      300

gctcggacac tctctgggca tcccctgggc tcccctgagc agctgcccca gccaggccct      360

gcagctggca ggctgcttga gccaactcca tagcggcctt ttcctctacc aggggctcct      420

gcaggccctg gaagggatct cccccgagtt gggtcccacc ttggacacac tgcagctgga      480

cgtcgccgac tttgccacca ccatctggca gcagatggaa gaactgggaa tggcccctgc      540

cctgcagccc acccagggtg ccatgccggc cttcgcctct gctttccagc gccgggcagg      600

aggggtcctg gttgcctccc atctgcagag cttcctggag gtgtcgtacc gcgttctacg      660

ccaccttgcc cagccctgaa gcgctgcctt ctgcggggct tgccttctgg ccatgccctt      720

cttctctccc ttgcacctgt acctcttggt ctttgaataa agcctgagta ggaaggcggc      780

cgctcgagca tgcatctaga                                                  800


<210>  29
<211>  800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  29
taatacgact cactataggg aaataagaga gaaaagaaga gtaagaagaa atataagagc       60

caccatggcc ggtcccgcga cccaaagccc catgaaactt atggccctgc agttgctgct      120

ttggcactcg gccctctgga cagtccaaga agcgactcct ctcggacctg cctcatcgtt      180

gccgcagtca ttccttttga agtgtctgga gcaggtgcga aagattcagg gcgatggagc      240

cgcactccaa gagaagctct gcgcgacata caaactttgc catcccgagg agctcgtact      300

gctcgggcac agcttgggga ttccctgggc tcctctctcg tcctgtccgt cgcaggcttt      360

gcagttggca gggtgccttt cccagctcca ctccggtttg ttcttgtatc agggactgct      420

gcaagccctt gagggaatct cgccagaatt gggcccgacg ctggacacgt tgcagctcga      480

cgtggcggat ttcgcaacaa ccatctggca gcagatggag gaactgggga tggcacccgc      540

gctgcagccc acgcaggggg caatgccggc ctttgcgtcc gcgtttcagc gcagggcggg      600

tggagtcctc gtagcgagcc accttcaatc atttttggaa gtctcgtacc gggtgctgag      660

acatcttgcg cagccgtgaa gcgctgcctt ctgcggggct tgccttctgg ccatgccctt      720

cttctctccc ttgcacctgt acctcttggt ctttgaataa agcctgagta ggaaggcggc      780

cgctcgagca tgcatctaga                                                  800


<210>  30
<211>  758
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  30
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gccggucccg       60

cgacccaaag ccccaugaaa cuuauggccc ugcaguugcu gcuuuggcac ucggcccucu      120

ggacagucca agaagcgacu ccucucggac cugccucauc guugccgcag ucauuccuuu      180

ugaagugucu ggagcaggug cgaaagauuc agggcgaugg agccgcacuc caagagaagc      240

ucugcgcgac auacaaacuu ugccaucccg aggagcucgu acugcucggg cacagcuugg      300

ggauucccug ggcuccucuc ucguccuguc cgucgcaggc uuugcaguug gcagggugcc      360

uuucccagcu ccacuccggu uuguucuugu aucagggacu gcugcaagcc cuugagggaa      420

ucucgccaga auugggcccg acgcuggaca cguugcagcu cgacguggcg gauuucgcaa      480

caaccaucug gcagcagaug gaggaacugg ggauggcacc cgcgcugcag cccacgcagg      540

gggcaaugcc ggccuuugcg uccgcguuuc agcgcagggc ggguggaguc cucguagcga      600

gccaccuuca aucauuuuug gaagucucgu accgggugcu gagacaucuu gcgcagccgu      660

gaagcgcugc cuucugcggg gcuugccuuc uggccaugcc cuucuucucu cccuugcacc      720

uguaccucuu ggucuuugaa uaaagccuga guaggaag                              758


<210>  31
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  31
gggaaataag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  32
<211>  102
<212>  DNA
<213>  Mus musculus

<400>  32
tgataatagg ctgccttctg cggggcttgc cttctggcca tgcccttctt ctctcccttg       60

cacctgtacc tcttggtctt tgaataaagc ctgagtagga ag                         102


<210>  33
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Glu Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  34
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Asp Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  35
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Ala Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  36
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Ala Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  37
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Ala 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  38
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Ala Ala Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Ala Leu Lys Ile Gly Ala 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  39
<211>  1512
<212>  DNA
<213>  Homo sapiens

<400>  39
atgatgacca catctttgat ttgggggatt gctatagcag catgctgttg tctatggctt       60

attcttggaa ttaggagaag gcaaacgggt gaaccacctc ttgagaatgg attaattcca      120

tacctgggct gtgctctgca atttggtgcc aatcctcttg agttcctcag agcaaatcaa      180

aggaaacatg gtcatgtttt tacctgcaaa ctaatgggaa aatatgtcca tttcatcaca      240

aatcccttgt cataccataa ggtgttgtgc cacggaaaat attttgattg gaaaaaattt      300

cactttgcta cttctgcgaa ggcatttggg cacagaagca ttgacccgat ggatggaaat      360

accactgaaa acataaacga cactttcatc aaaaccctgc agggccatgc cttgaattcc      420

ctcacggaaa gcatgatgga aaacctccaa cgtatcatga gacctccagt ctcctctaac      480

tcaaagaccg ctgcctgggt gacagaaggg atgtattctt tctgctaccg agtgatgttt      540

gaagctgggt atttaactat ctttggcaga gatcttacaa ggcgggacac acagaaagca      600

catattctaa acaatcttga caacttcaag caattcgaca aagtctttcc agccctggta      660

gcaggcctcc ccattcacat gttcaggact gcgcacaatg cccgggagaa actggcagag      720

agcttgaggc acgagaacct ccaaaagagg gaaagcatct cagaactgat cagcctgcgc      780

atgtttctca atgacacttt gtccaccttt gatgatctgg agaaggccaa gacacacctc      840

gtggtcctct gggcatcgca agcaaacacc attccagcga ctttctggag tttatttcaa      900

atgattagga acccagaagc aatgaaagca gctactgaag aagtgaaaag aacattagag      960

aatgctggtc aaaaagtcag cttggaaggc aatcctattt gtttgagtca agcagaactg     1020

aatgacctgc cagtattaga tagtataatc aaggaatcgc tgaggctttc cagtgcctcc     1080

ctcaacatcc ggacagctaa ggaggatttc actttgcacc ttgaggacgg ttcctacaac     1140

atccgaaaag atgacatcat agctctttac ccacagttaa tgcacttaga tccagaaatc     1200

tacccagacc ctttgacttt taaatatgat aggtatcttg atgaaaacgg gaagacaaag     1260

actaccttct attgtaatgg actcaagtta aagtattact acatgccctt tggatcggga     1320

gctacaatat gtcctggaag attgttcgct atccacgaaa tcaagcaatt tttgattctg     1380

atgctttctt attttgaatt ggagcttata gagggccaag ctaaatgtcc acctttggac     1440

cagtcccggg caggcttggg cattttgccg ccattgaatg atattgaatt taaatataaa     1500

ttcaagcatt tg                                                         1512


<210>  40
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  40
gggaaataag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  41
<211>  119
<212>  DNA
<213>  Homo sapiens

<400>  41
tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc cccccagccc       60

ctcctcccct tcctgcaccc gtacccccgt ggtctttgaa taaagtctga gtgggcggc       119


<210>  42
<211>  2726
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  42
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gguccguggg       60

gcuggaagcu uagauggaca gucgcgcucc uccuugcagc agcaggaacu gcggucggag      120

aucgaugcga gcgcaacgag uuccaaugcc aagaugggaa guguauuucg uacaaguggg      180

ucugcgaugg aucagcggaa ugucaggacg gaagcgauga gagccaagaa acaugccucu      240

cagugacaug caagucggga gacuucucgu gcggaggacg cguaaacaga uguauuccac      300

aguuuuggcg cugcgauggu cagguggacu gcgacaacgg uucagaugaa cagggauguc      360

cuccgaaaac gugcucacaa gacgaguuuc gcugccauga uggaaagugc auuucgcggc      420

aguucguaug ugauucggau cgggacuguc uggacggcuc ggacgaagcg ucaugcccgg      480

uacuuacuug cgggccagcc ucauuccaau gcaacagcuc aacgugcauu ccccagcugu      540

gggccuguga caaugauccu gauugugagg acgguagcga cgaguggccg cagagaugua      600

gggguuugua cguauuccaa ggagacucaa gccccuguuc cgccuuugag uuucacugcc      660

ugucggguga augcauccac uccagcuggc gaugugaugg ugggcccgac ugcaaagaua      720

agagcgacga ggagaauugc gcggucgcga cgugcagacc cgaugaguuc cagugcuccg      780

auggaaacug cauccacggg agccggcagu gugaucgcga guacgauugu aaagacaugu      840

cagacgaggu cggaugcgug aacgucacgu ugugcgaggg uccgaacaag uuuaagugcc      900

auucgggcga auguauuacg cucgauaaag ucugcaacau ggcgcgagau uguagggauu      960

ggucagacga acccaucaag gagugcggca cuaacgagug uuuggacaau aacggcgggu     1020

guucgcacgu cugcaaugau cucaaaauug gguaugagug ucucuguccu gacggauucc     1080

agcuggucgc gcagcgcaga ugcgaggaca ucgacgagug ccaggacccc gacacauguu     1140

cgcaguugug ugucaaccuu gaaggagggu acaagugcca gugcgaggag ggauuucagc     1200

uugacccgca cacgaaagca uguaaagcgg ugggguccau ugcguauuug uuuuucacaa     1260

acagacauga agugcggaag augacccuug aucgcagcga auauacguca cugaucccua     1320

aucuuaggaa ugucguggcc cuugacacgg agguagcauc aaauagaauc uacugguccg     1380

accucucaca gagaaugauc uguucaacac aguuggaucg ggcgcacggg gugucgucgu     1440

acgauacggu aauuagccgc gacauccagg cgccagacgg acucgcgguc gacuggaucc     1500

auagcaacau cuacuggaca gacuccgugu ugggaaccgu auccguagcu gacacaaagg     1560

gagugaagcg gaaaacucuu uuuagagaga acggcagcaa accgagagca aucguggucg     1620

auccggugca uggauucaug uauuggaccg auuggggaac gccagccaaa aucaagaaag     1680

gcgguuugaa uggggucgac aucuacucgc uggugacuga gaauauucag uggccaaacg     1740

ggaucaccuu ggacuuguug ucggggaggu uguauugggu ggacucaaag cuccacucga     1800

ucagcucgau cgacgugaac ggcggaaaua ggaaaacuau ucucgaagau gagaaaagac     1860

uggcccaccc cuucucgcuc gcgguguucg aggacaaagu auuuuggaca gacaucauca     1920

acgaagcgau cuuuucagcc aaccgccuga cagggucgga ugucaaucuc uuggccgaaa     1980

accuucugag cccggaagau auggucuugu uucacaauuu gacccaaccc agagguguga     2040

auuggugcga acggacgaca uugucgaacg gagguugcca guaucucugu cucccugcac     2100

cccagauuaa uccccauuca cccaaguuca cgugugcgug cccagacgga augcuucuug     2160

cgagggacau gagauccugu cucaccgaag cggaagcggc aguggccaca caagagacuu     2220

cgacuguccg ccuuaaagug uccucgacgg cgguccgaac ucagcauacg accacacgac     2280

ccgugcccga uaccucgcgg uugcccggag caacaccggg guugacgaca guagaaaucg     2340

uaaccaugag ccaccaggca cuuggagaug ucgcaggcag aggcaaugag aagaaaccca     2400

gcucggucag agcccucagc aucgugcugc cuauugugcu gcuuguguuu cucuguuugg     2460

guguguucuu guuguggaag aacuggcgcc uuaagaauau caacucgauu aacuucgaua     2520

auccgguaua ccagaaaacc acagaggaug aagugcauau uugucacaac caagauggcu     2580

auucguaccc guccaggcaa augguaucac uugaggacga cguggccuga uaagcugccu     2640

ucugcggggc uugccuucug gccaugcccu ucuucucucc cuugcaccug uaccucuugg     2700

ucuuugaaua aagccugagu aggaag                                          2726


<210>  43
<211>  854
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  43
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug guauccaagg       60

gggaggagga caacauggcg aucaucaagg aguucaugcg auucaaggug cacauggaag      120

guucggucaa cggacacgaa uuugaaaucg aaggagaggg ugaaggaagg cccuaugaag      180

ggacacagac cgcgaaacuc aaggucacga aagggggacc acuuccuuuc gccugggaca      240

uucuuucgcc ccaguuuaug uacgggucca aagcauaugu gaagcauccc gccgauauuc      300

cugacuaucu gaaacucagc uuucccgagg gauucaagug ggagcggguc augaacuuug      360

aggacggggg uguagucacc guaacccaag acucaagccu ccaagacggc gaguucaucu      420

acaaggucaa acugcggggg acuaacuuuc cgucggaugg gccggugaug cagaagaaaa      480

cgaugggaug ggaagcguca ucggagagga uguacccaga agauggugca uugaaggggg      540

agaucaagca gagacugaag uugaaagaug ggggacauua ugaugccgag gugaaaacga      600

cauacaaagc gaaaaagccg gugcagcuuc ccggagcgua uaaugugaau aucaaguugg      660

auauuacuuc acacaaugag gacuacacaa uugucgaaca guacgaacgc gcugagggua      720

gacacucgac gggaggcaug gacgaguugu acaaaugaua agcugccuuc ugcggggcuu      780

gccuucuggc caugcccuuc uucucucccu ugcaccugua ccucuugguc uuugaauaaa      840

gccugaguag gaag                                                        854


<210>  44
<211>  1796
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  44
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gaagaugcga       60

agaacaucaa gaagggaccu gccccguuuu acccuuugga ggacgguaca gcaggagaac      120

agcuccacaa ggcgaugaaa cgcuacgccc ugguccccgg aacgauugcg uuuaccgaug      180

cacauauuga gguagacauc acauacgcag aauacuucga aaugucggug aggcuggcgg      240

aagcgaugaa gagauauggu cuuaacacua aucaccgcau cguggugugu ucggagaacu      300

cauugcaguu uuucaugccg guccuuggag cacuuuucau cggggucgca gucgcgccag      360

cgaacgacau cuacaaugag cgggaacucu ugaauagcau gggaaucucc cagccgacgg      420

ucguguuugu cuccaaaaag gggcugcaga aaauccucaa cgugcagaag aagcucccca      480

uuauucaaaa gaucaucauu auggauagca agacagauua ccaaggguuc cagucgaugu      540

auaccuuugu gacaucgcau uugccgccag gguuuaacga guaugacuuc guccccgagu      600

cauuugacag agauaaaacc aucgcgcuga uuaugaauuc cucggguagc accgguuugc      660

caaagggggu ggcguugccc caccgcacug cuugugugcg guucucgcac gcuagggauc      720

cuaucuuugg uaaucagauc auucccgaca cagcaauccu guccguggua ccuuuucauc      780

acgguuuugg cauguucacg acucucggcu auuugauuug cgguuucagg gucguacuua      840

uguaucgguu cgaggaagaa cuguuuuuga gauccuugca agauuacaag auccagucgg      900

cccuccuugu gccaacgcuu uucucauucu uugcgaaauc gacacuuauu gauaaguaug      960

accuuuccaa ucugcaugag auugccucag ggggagcgcc gcuuagcaag gaagucgggg     1020

aggcaguggc caagcgcuuc caccuucccg gaauucggca gggauacggg cucacggaga     1080

caacauccgc gauccuuauc acgcccgagg gugacgauaa gccgggagcc gucggaaaag     1140

ugguccccuu cuuugaagcc aaggucguag accucgacac gggaaaaacc cucggaguga     1200

accagagggg cgagcucugc gugagagggc cgaugaucau gucagguuac gugaauaacc     1260

cugaagcgac gaaugcgcug aucgacaagg augggugguu gcauucggga gacauugccu     1320

auugggauga ggaugagcac uucuuuaucg uagaucgacu uaagagcuug aucaaauaca     1380

aaggcuauca gguagcgccu gccgagcucg agucaauccu gcuccagcac cccaacauuu     1440

ucgacgccgg aguggccggg uugcccgaug acgacgcggg ugagcugcca gcggccgugg     1500

uaguccucga acaugggaaa acaaugaccg aaaaggagau cguggacuac guagcaucac     1560

aagugacgac ugcgaagaaa cugaggggag ggguagucuu uguggacgag gucccgaaag     1620

gcuugacugg gaagcuugac gcucgcaaaa uccgggaaau ccugauuaag gcaaagaaag     1680

gcgggaaaau cgcugucuga uaagcugccu ucugcggggc uugccuucug gccaugcccu     1740

ucuucucucc cuugcaccug uaccucuugg ucuuugaaua aagccugagu aggaag         1796


<210>  45
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ile Cys Ser Thr Gln Leu Asp Arg 
1               5                   


<210>  46
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  46

Leu Ala His Pro Phe Ser Leu Ala Val Phe Glu Asp Lys 
1               5                   10              


<210>  47
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  47

Asn Val Val Ala Leu Asp Thr Glu Val Ala Ser Asn Arg 
1               5                   10              


<210>  48
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  48

Thr Cys Ser Gln Asp Glu Phe Arg 
1               5               


<210>  49
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  49

Val Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn 
1               5                   10                  15      


Pro Lys 
        


<210>  50
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  50

Val Val Asp Leu Met Ala His Met Ala Ser Lys 
1               5                   10      


<210>  51
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  51

His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg 
1               5                   10                  15  


<210>  52
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  52

Tyr Ile Asp Gln Glu Glu Leu Asn Lys 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  53

Asp Gln Leu Ile Tyr Asn Leu Leu Lys 
1               5                   


<210>  54
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Glu Met Met Asp Leu Gln His Gly Ser Leu Phe Leu Arg 
1               5                   10                  


<210>  55
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  55

Ala Leu Glu Ser Pro Glu Arg Pro Phe Leu Ala Ile Leu Gly Gly Ala 
1               5                   10                  15      


Lys 
    


<210>  56
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  56

Leu Gly Asp Val Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg 
1               5                   10                  15  


<210>  57
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  57

Ile Ile Gln Leu Leu Asp Asp Tyr Pro Lys 
1               5                   10  


<210>  58
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  58

Ala Val Gly Ser Ile Ala Tyr Leu Phe Phe Thr Asn Arg 
1               5                   10              


<210>  59
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Glu Tyr Thr Ser Leu Ile Pro Pro Leu Arg 
1               5                   10      


<210>  60
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  60

Ile Gly Ala Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln 
1               5                   10                  15      


Arg 
    


<210>  61
<211>  1805
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Transcript Sequence

<400>  61
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gcggucgagu       60

cgcaaggugg acggccucuu gugcuugguu ugcuccuuug uguacucggc ccugucgugu      120

cacacgccgg gaagauuuug uugauccccg uggacggauc acauuggcuu ucgaugcucg      180

gagccaucca gcaguugcag caaagggggc augagauugu gguccuggcu ccggacgcgu      240

cgcucuacau ucgcgauggu gcauucuaua cucuuaagac auauccagug cccuuccagc      300

gcgaagaugu caaagaguca uuugucucac ugggacacaa cguauucgag aacgacuccu      360

ucuugcagag agucaucaag acguacaaga aaaucaaaaa ggauagcgcc augcuguugu      420

cagggugcuc gcacuugcuu cacaacaagg agcugauggc gucacuggcg gagucgagcu      480

uugaugucau guugacggac ccguuuuugc cguguagccc gaucguggcg caauacuugu      540

cccuucccac cguauucuuc cuccacgcgc uucccuguag ccuggaguuu gaggcgaccc      600

agugucccaa ucccuuuuca uacgugccuc gaccguuguc aucacauucg gaccacauga      660

cguuccucca gcgggugaag aauaugcuca ucgccuuuuc ccaaaacuuc cucugcgacg      720

ucgucuacuc cccuuacgcc acgcuggcau ccgaguuucu gcagcgagag gugacugugc      780

aagaccuucu cucgucggca ucaguauggu uguuccgauc agauuucgua aaggacuacc      840

caagacccau caugcccaac augguguucg uagggggaau caauugccuc caccagaauc      900

cgcugagcca ggaguuugaa gcguauauca acgcgucggg ggaacacgga auugucgugu      960

uuagccuggg gucgauggua ucggagauuc ccgaaaagaa ggcgauggca aucgcagacg     1020

cacucggaaa gaucccccag acaguccuuu ggcgguauac agggacgagg ccgagcaauu     1080

uggcaaacaa uacgauccuu gugaaauggu ugccgcagaa ugaucuucuc ggucauccca     1140

ugacaagagc cuucaucacg cacgccgguu cgcauggggu auaugaaucg auuugcaaug     1200

gcgugccuau ggugaugaug ccgcucuuug gugaccagau ggacaaugcg aaaaggaugg     1260

aaaccaaggg agcaggaguc acccugaaug ugcuggaaau gacauccgag gaucucgaaa     1320

acgcgcuuaa agcggucauu aacgacaaau cguauaagga aaacaucaug agguugagcu     1380

cccuucacaa agauagaccu gucgagccau uggaccuggc cguguuuugg gucgaguucg     1440

ugaugcggca caagggagcg ccacacuuga ggccagcugc gcaugaucug acgugguauc     1500

aguaccacuc ccucgaugug auuggcuucc ugcuggcagu cguguugacu guggcguuua     1560

ucacauucaa auguugcgcu uacggcuacc ggaagugcuu gggaaagaaa ggacgcguga     1620

aaaaggccca uaagucgaaa acacauugau aagcugccuu cugcggggcu ugccuucugg     1680

ccaugcccuu cuucucuccc uugcaccugu accucucaaa caccauuguc acaaacacca     1740

uugucacaaa caccauuguc acaaacacca uugucauggu cuuugaauaa agccugagua     1800

ggaag                                                                 1805


<210>  62
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  62

Asn Phe Asp Asn Pro Val Tyr Gln 
1               5               


<210>  63
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  63

Asn Gln Asp Gly Tyr Ser Tyr Pro Ser Arg 
1               5                   10  


<210>  64
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  64

Leu Glu Asp Asp Val Ala 
1               5       


