                               SEQUENCE LISTING

<110> TRUSTEES OF BOSTON UNIVERSITY
 
<120> POLYMORPHISM OF THROMBOSPONDIN-1 AS A BIOMARKER FOR 
      SUSCEPTIBILITY TO DRY EYE

<130> 701586-080911-PCT

<140> PCT/US14/27343
<141> 2014-03-14

<150> 61/800,881
<151> 2013-03-15

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 16389
<212> DNA
<213> Homo sapiens

<400> 1
agccgctgcg cccgagctgg cctgcgagtt cagggctcct gtcgctctcc aggagcaacc       60

tctactccgg acgcacaggc attccccgcg cccctccagc cctcgccgcc ctcgccaccg      120

ctcccggccg ccgcgctccg gtacacacag gtaagtcgcc cccggcggcc gccgaggacc      180

aaagctgccc gggacatcca cctggagcgc tgaggcttca gtccctctgg tggaccccgg      240

aacctacact ctccccgctc gcctacccca gcccgctcct ctcagccgct ggaggactct      300

tcagggcaag gctccagagc catcctctcc agccttgagg ttcacaaacc aactcatcag      360

gacaccccaa gatttcctta ctctctgaag tcctccttaa gcctttgtat cagcactcca      420

gggaagagtc tgtacttccc ctgccctccc tgcaacccca aactacagtt cctgatcttg      480

ctcaccttcg acttcccaaa agcccccaaa ttgttggtct tgcgcccccc acactttaaa      540

accagcatct ctttcctcca cctctctctc tctctctctc tctctctctc atgctctctg      600

gaaagtaatc ctgttgtcct tcatttcagc aaacgcgggg tcaaagaggg atggtcccgg      660

ccctgtcccc atgcccagcc ccgtttctgc gcaccgtccc tccctgccta gctgatctct      720

gaccctcggc tcttgtgctt cctgctacag gatccctgct gggcaccaac agctccacca      780

tggggctggc ctggggacta ggcgtcctgt tcctgatgca tgtgtgtggc accaaccgca      840

ttccaggtga gtttgtgtgg cacctttagg ggaaggaggg acaaggaaga ggtgctggct      900

atcccaggtg tgccccctca cgtgctgtcc tctccctctt gagcctgact ggacatcagg      960

acgcagcttc actctgatcc tggtatttat tcacctcttt cagtggttgc caggagtttt     1020

caccccaacc ctttgtctcc acccctaagg actcagcccc ctactgctgg tcccagccta     1080

gaaagctcac tttgtgttct ctcctgtcta acagagtctg gcggagacaa cagcgtgttt     1140

gacatctttg aactcaccgg ggccgcccgc aaggggtctg ggcgccgact ggtgaagggc     1200

cccgaccctt ccagcccagc tttccgcatc gaggatgcca acctgatccc ccctgtgcct     1260

gatgacaagt tccaagacct ggtggatgct gtgcgggcag aaaagggttt cctccttctg     1320

gcatccctga ggcagatgaa gaagacccgg ggcacgctgc tggccctgga gcggaaagac     1380

cactctggcc aggtcttcag cgtggtgtcc aatggcaagg cgggcaccct ggacctcagc     1440

ctgaccgtcc aaggaaagca gcacgtggtg tctgtggaag aagctctcct ggcaaccggc     1500

cagtggaaga gcatcaccct gtttgtgcag gaagacaggg cccagctgta catcgactgt     1560

gaaaagatgg agaatgctga gttggacgtc cccatccaaa gcgtcttcac cagagacctg     1620

gccagcatcg ccagactccg catcgcaaag gggggcgtca atgacaattt ccaggtgagg     1680

cttcttctct gagccctgct ccgtgggatc atctgctaga caggtgacct gccaggaggg     1740

ctacaggaaa tcctgtctgt aaactaacgc agcagttctc agattttagg cagcatgagc     1800

atcacctgga gggcttgtga aagctcaccc tgctgcaccc cagccccaga gtctgggatt     1860

ctgtaaaact gcaactctaa caagtaccag gtgatgctga tgccggtggt ctgggaagca     1920

cactttgaaa actactcaag gaaacaagaa atggttttcc tttagcagtc agcctgttca     1980

agccttagat actccttagg ctcttaagaa aagagcttat ttcaaatgca ttcccccaat     2040

tttaatcttg tttgaaatgg atactttcta tgggcagaat cagtaccact ttgctattgg     2100

attcctcatg gggatgcagc tggtctcaca taaaaggtta aaatagcagt tagttgttgc     2160

tgttacagct tcatctgtgc cttaacttct agatctttgc aacggtggct ttgaactccc     2220

acatttaact ctttgacact ggaaagtgtc attatatcct ctaggcttag gatcagattc     2280

catttcctgt gtacccaagt aggctgataa ctgaattctt tgtaaaatac tcaagacttg     2340

gcagaagtca caattaagat tttgaagttg tttggcgatt aatgttgctg tgttattttg     2400

acatagtgat cttaagacag ctctttgaag cttttagaac atctattgta tgcttttcct     2460

agcatacaga cagtctcccc caaccccatc cccaccccgc tctgcattct acaagtaatg     2520

tgtgtcctct gcccacaggg ggtgctgcag aatgtgaggt ttgtctttgg aaccacacca     2580

gaagacatcc tcaggaacaa aggctgctcc agctgtgagt acccctctat ttttagggca     2640

catagggaat cagggggaat tccaccaaaa acaaactgag gaatttagca atagtggtta     2700

tacataaatt acccccagtg agatcatcaa gaggcataca gaagtgactc caaggggtat     2760

tatacacaca cacgtataca cacgtgcgca tacacgcaac ccctctacct gcatccttca     2820

caccaaatga aacgtcttct accactaaga actcaagagg ctggttggta agagtatcta     2880

tttgaagttt tcattttgtt tcttgccagc taccagtgtc ctcctcaccc ttgacaacaa     2940

cgtggtgaat ggttccagcc ctgccatccg cactaactac attggccaca agacaaagga     3000

cttgcaagcc atctgcggca tctcctgtga tgagctgtcc agcatggtcc tggaactcag     3060

gggcctgcgc accattgtga ccacgctgca ggacagcatc cgcaaagtgg tcagtggcct     3120

ctgcacccag cccgttagca tgaaccctgg aaggtttatc gcagatggtc ccaaatgact     3180

gaaaatgcgg ggggacacta atgatattct ctcccattta gactgaagag aacaaagagt     3240

tggccaatga gctgaggcgg cctcccctat gctatcacaa cggagttcag tacagaaata     3300

acgaggaatg gactgttgat agctgcactg agtgtcactg tcaggtaagg gaccttcacc     3360

agccagaata agaatcgacg gcttttgttt gaacctacat ctttggggaa ataccctaat     3420

cgccacagag attcttttta tgttccatgg cctgataaca aagtgttttt tttttcttta     3480

agatgcaatt atggcatcta taagttcttc tttaaactct cagatggttt atcaaagtat     3540

taattatacc ccaggctaag tatctaagag aatgaatcta ctaagacatc tgaataattt     3600

acctacctta gttcaaagac taagtgttga atgtcaggta aataaaacct ggttggaaca     3660

ttcatttttt tttcccaacc ctgatttata ttcagctttg gcataggttc ttttagtaca     3720

gtagcaattg tttttcaaat cacttagtct gacactgtta ggatgttact gtctgctttg     3780

ctcagatggc actgccaggt gtgtgattca ctctagcatc cccgcatgcc agtggccagt     3840

gagtttggag gttcacctgg cttatctatt aatagcaaag tatttgaatt tgcttaaata     3900

caaatcacag atgactggct gtgggaacca acttcattaa attccctttc ttttccaata     3960

taaagacaga tcacagatct atagatgagg aaaaagtgct tatagatctt ccttcctccc     4020

cccaaacaca taatataaaa atgtaaaagt cctggctgaa ttttctgagt ttgatttcag     4080

acatagattt gacccatgat gtttgttggt tcctctgcta taaattcttt gtactgtaac     4140

ttccaccctt gactaagtag caattaaaaa gaactttcca aggaatggag tgacacgtaa     4200

actagcacta gaactgtctc tacgatagtg gtggctgcaa atatgacaga gacagatcta     4260

tgaaaatcat tccactagag cattgacagc cctgaccatg ttttggcttg taaaggaaat     4320

gttacaggat gtagacttct gtatgcaaca tgctcagcag cctgttcccc tctcactctc     4380

ttgccctgca gaactcagtt accatctgca aaaaggtgtc ctgccccatc atgccctgct     4440

ccaatgccac agttcctgat ggagaatgct gtcctcgctg ttggcgtaag tttctcaaat     4500

ggcatagcta ttcttcagtg actaggtcag ttctacatac atcctagaca gccgagcaca     4560

acactggaac cccaccccca tctccatcat gcttccattc agtttcttgc tgcagcagct     4620

ggttaactga cagcttatct gctgtacaga gccaaaactc cattatgagt acatcgtaat     4680

tacccatctg gattgcagta atggcagtga agatcttggt atagctcatt aattctgatt     4740

ttttgctttg aggaaaagag atgaagacgt ggcagcaaca gctctaagtt gactgctttt     4800

agaatttgac cttagtggca cagagttaag aaaaatctgc tcaccagaga tattgacagg     4860

cttactgtgt aagcattggc ctgatcgggc ctggaagttt tgcccctttc atctgtaggg     4920

ataagagggc ctaagagaat agcagcaatc tgagctctag agcaccaaaa gaaataaggc     4980

acgatatcgt tccatggcac gttatccctg gcttttgtta ccagtaaaat gaatgacttt     5040

gctgagacaa tacttagtgt agcaggtaca agttataaaa gtgattcatt acaactaaga     5100

taaggaagaa aacaggaaaa cagcacttgc ccttcacaca cacagaaaca cacatgcaca     5160

cacacacaaa cacacccttg tcacagctca gaataaccaa ttccatccag ggatcatatt     5220

agcgatattg gcactgtaat ggtcgttttt acatttattt tctgttccgc attcacttaa     5280

catgtgcgtt aaaaggaaca aagctagctg gaggtagcaa agttttgaac ttgaatcagg     5340

gattgctaag aaaacttaca actaatgacc acagaaagta agttctttgt cttctgtctg     5400

atacagctag atgtgattgt agccgtggtg cctgggcaga tggtaaacaa acatgctgtc     5460

ctcttatgac aatatgtgca gagaaggccc caaacgctgg ggtgagagga acaacaaact     5520

gactaactca cggccgagtt ggagccagaa ccaacaacag ctcggctgcc ttcacactca     5580

tctgtcaaac acatggtgta tggctcccct gacagaaatg actcctataa gcttcctcat     5640

actcgcgcat tcttggaagt ctgagactgg aaatgcctac ccagatatgt taagtcagta     5700

aaggaaaact catttgcaat gctgagagga gaaagaaaat caatgaatag gagagcatac     5760

actgtgggaa ggctcagctg tactgagcca ggcaaagcat ccgattaccc cactgctgta     5820

cacatcatga cctgggataa acccctgggc cgttggccta agaaatatgt tgcttttcat     5880

cctgtataac tgcaactttg tgccggctca tattatgttc tagagagctc atgtacacca     5940

tggtgaccat agttaataat actggattgt atgcttaaaa tttgctaaga gagtagatct     6000

taagtcatca ccaaaaaaag taactgtaag atgatggaga tgtgttaatt agcttgacgg     6060

tggtaatcac aatatatgtg tatatcaaaa catcacatta tacaccttaa atgtatataa     6120

tatttgtcaa ttatacctca gtaaagccaa aaagaaataa atatattgct tttcaccctc     6180

tggcaagtgg agggccctga acagagccct ctaaagaaca gcttgtccta atcatcacgt     6240

acctgatgaa cctctgtttc ccctgcagcc agcgactctg cggacgatgg ctggtctcca     6300

tggtccgagt ggacctcctg ttctacgagc tgtggcaatg gaattcagca gcgcggccgc     6360

tcctgcgata gcctcaacaa ccgatgtgag ggctcctcgg tccagacacg gacctgccac     6420

attcaggagt gtgacaagag atgtaagcat cttagcctct cagggacgtg gagaactgac     6480

ctgtccttgt tgtcgtcacc aagggcagct ccacagcatg tatattaaga acacgggttc     6540

taggatctct ggatcccaat cccactgctt agctgtgcac ccttgaacac aacttaccct     6600

ctctgaggct ctttcctcat ttgcaacttg gagataataa tagttcttga taagtttatc     6660

ttgagcattt tatttagata ctgcatgtaa agcagttagc actgagtttt ggtttatggt     6720

aagcaccctg taaatgttag gatattaaca gcaacccata aaaacagcga acttatccgt     6780

tctctggtag aaaacattcc atgttgacat ttgggcatgt ggccaggagc caatttctac     6840

cgtacactgg gtttagttgc cattgaccat ttcctggaaa tacttctgcg tgctcctgat     6900

gggagcctct atttggctgt ctctaagcca aaaccatttg tgaccatcaa ctctgtactt     6960

tagttaaaca ggatggtggc tggagccact ggtccccgtg gtcatcttgt tctgtgacat     7020

gtggtgatgg tgtgatcaca aggatccggc tctgcaactc tcccagcccc cagatgaacg     7080

ggaaaccctg tgaaggcgaa gcgcgggaga ccaaagcctg caagaaagac gcctgcccca     7140

gtaagtgtga ggtccgctgc aagggtgagc atgggcagca gctctgccca gctggttgcc     7200

tggcatctgc agcctgcagt tcagtgggtc atagagcagg aaggttacct actagagaaa     7260

caaacagaag caaagtcctg caggctcagc aacttctttt aatgaaaaac aaactcaccc     7320

tcttccccag cattctttcc atgtgtcaga gaagcagagg tttcttgaac gggcttagga     7380

gagtctatga caagggaggg atttgaaagt tgatcttaat tgttgcctgt ggttcatctt     7440

cttacagtca atggaggctg gggtccttgg tcaccatggg acatctgttc tgtcacctgt     7500

ggaggagggg tacagaaacg tagtcgtctc tgcaacaacc ccacacccca gtttggaggc     7560

aaggactgcg ttggtgatgt aacagaaaac cagatctgca acaagcagga ctgtccaatt     7620

ggtgagccac gcagcccagg atgaaacgac ccaggagctt tgctctttta ctgaatgctg     7680

cagtcagcat tcgaggagat tccagcttgg ttagtcctga gcgatttgat tgctctaaga     7740

tgcaggtgga caacataatc ccaacaagtt atcggttccc tataccctat aatatcttac     7800

actgtgttaa gtgcccagca tggcagtatg gcagcttaga ccaaccattt actgtgactg     7860

tctctctctc cttgtctcag atggatgcct gtccaatccc tgctttgccg gcgtgaagtg     7920

tactagctac cctgatggca gctggaaatg tggtgcttgt ccccctggtt acagtggaaa     7980

tggcatccag tgcacagatg ttgatgaggt gaggaactga tggggctccg agtttctgga     8040

tctaggaaag cagctaacct gtgcagtcgc ttccttatgg cagtgacttc taaacatgat     8100

gcacgctctt atttcctcca tagtgcaaag aagtgcctga tgcctgcttc aaccacaatg     8160

gagagcaccg gtgtgagaac acggaccccg gctacaactg cctgccctgc cccccacgct     8220

tcaccggctc acagcccttc ggccagggtg tcgaacatgc cacggccaac aaacaggtac     8280

agtcaactag acgagtaaac cagaggacag gagagctgtc cttgaccaaa ataactggga     8340

gcgggaggaa tgtaatttca tacccttcac caaaaaaaaa agggcgagga gatgaatgta     8400

cggtctagtt ttagaaacgt gattagaaaa tccatggtaa atcctgcagg ggaaaaacag     8460

tcttccatat ttaaaaatgc tgctctggaa taagttgtga gcagatggac ttgtaaacgc     8520

ctaggtgctg agcaaattca agaaaaataa acataaagca aagtttgctt atagcctcag     8580

ggagaatggg gagggacaga ggtaacccac actcttccaa atggagcctc tgtctactca     8640

gagatgacag ggatctggat tcttgtttcc atgatatctg aggattctca aaagctctgt     8700

gtaacagcag catggtgtac cctcaggtgt gcaagccccg taacccctgc acggatggga     8760

cccacgactg caacaagaac gccaagtgca actacctggg ccactatagc gaccccatgt     8820

accgctgcga gtgcaagcct ggctacgctg gcaatggcat catctgcggg gaggacacag     8880

acctggatgg ctggcccaat gagaacctgg tgtgcgtggc caatgcgact taccactgca     8940

aaaaggtaga gccaggtcct ttgtgtgcct ccagaaagag ggcccatcac cttatcaaaa     9000

cacaggctaa ggaattttaa atacttaaag tttggacatg aaactgaaag attaaatctc     9060

ccaaagggag aggggcacta attcctatta aaattaaatc acttggtgcc aaaaacatga     9120

acagggctag ctctttttgg gcaactgtgt tccatagtca actcttctgt ccaaaaaaaa     9180

gttcagtact ctatccaaat accagcaaag catgacttgt gttcacaaca tctataaagc     9240

ctagagcatt tacacaaatt ctgtatgtat atcccccaag aaaagtttta ttttcttgtc     9300

ttcccataaa aaaaatatgc tgttactgag ccaaattctg ttctttttct atttggaatt     9360

ccaggtacac tccctcgtgc atgagctcag catgaggaag gcaactgaag cagtgatata     9420

tatcttctct ttcctaggat aattgcccca accttcccaa ctcagggcag gaagactatg     9480

acaaggatgg aattggtgat gcctgtgatg atgacgatga caatgataaa attccagatg     9540

acagggtaaa aacagttttc tatccctttt tcatcttttc agttcagcaa cagcctgaaa     9600

cactttggga ttcaaggaaa ttacatggct atagcaaaaa atataccaaa tcaatacaca     9660

ggataattag aaattattca ttgtgttcca gtagtttaag gatgtagatg ttgccaagag     9720

aatttttaaa tgagggtttt gtttttcatc agaactgttt ttctctgtac ttgagaaatt     9780

ataatgcata aacaaatgcc actttgttcc ctagattcat ttcaaatgtc acatcgaaat     9840

tacagtaaaa ttgactttgg gcacactatg aactgagatg atgggattat attctacatc     9900

tcactaactt ctaacccaca gggatccatt tttttaacta tgtcctttta acttttgtag     9960

tgatcgtttt acactgagtg atcaattagc ctatccacta ggtagaaagt attgctgatt    10020

ttcacagttt tagacatatt atgcacatgg tttgaggctt gagctgtttt caaggacaac    10080

attgttaagt gctccatttc ttctctttgc aggacaactg tccattccat tacaacccag    10140

ctcagtatga ctatgacaga gatgatgtgg gagaccgctg tgacaactgt ccctacaacc    10200

acaacccaga tcaggcagac acagacaaca atggggaagg agacgcctgt gctgcagaca    10260

ttgatggaga cggtaaggtg ctgcctgatc agagggcccg cgggagacag ggacatgcac    10320

agctttccaa acgtacttct gtctagtcct ggctattagt atgcactttg gtggaaacat    10380

ccaaggctgg agagcccagc tcttatttgt cccttgttct cttcaggtat cctcaatgaa    10440

cgggacaact gccagtacgt ctacaatgtg gaccagagag acactgatat ggatggggtt    10500

ggagatcagt gtgacaattg ccccttggaa cacaatccgg atcaggtagg tggatggact    10560

cctttcagag tctttcagta aactgttgga atatcccttt catggccttt gaaaaatgag    10620

cttaacaaag ttcaaacact ttcattactg tggctccctg gcttctcata gccaactgga    10680

atacgttcat gtaaataatt tgcctgatgt gagctccttg cacagagtct cacagatctt    10740

tagcatgaag atctggtaac ttcagtctta ccttctgtaa gaagggctac tggacttgct    10800

cagcatcgtc taccattgtt aagacaaatt atacaaagca gacatctgtg actgacaact    10860

gtacaataat attaatcata tgtaatacta agagatggaa aaataaatgt gcataagcaa    10920

aataaccatt ttcatggcta atgatgtaat ctagctataa gaaaatcatc aaactaagga    10980

tacatccaaa accaaagtaa tttatccctg tcataaacat tacccagaca gtatacaaca    11040

cagggaccag tggtctgttt ccatcttttc aggacttttc agagaagtcg acgtgtcaac    11100

agttttacaa ctgaaacctt ctaaggaaat tctctgttat aaagtatcca gaaaatttca    11160

tttaacatta agatgtaaac agttaacatt tcatttcatc tttagtaatt aaatatcact    11220

ctatttgacc ttatttagaa agttttatat gtaaaacatt tttaaattat cccttctcag    11280

atttttatac gaaaacaaag ataaaggaaa aaaactttta aaatgtaatt gctactattg    11340

ctatctttct gcaggagtgt gtaaatagac atgacacccc actggctgta tcaaacaatg    11400

gagaattttc cctgtggtgg gggcataagt tatctttaac atgaatggtt tatactgcaa    11460

tttaccctcc atttacatct ctctttcagc tggactctga ctcagaccgc attggagata    11520

cctgtgacaa caatcaggat attgatgaag atggccacca gaacaatctg gacaactgtc    11580

cctatgtgcc caatgccaac caggctgacc atgacaaaga tggcaaggga gatgcctgtg    11640

accacgatga tgacaacgat ggcattcctg atgacaagga caactgcaga ctcgtgccca    11700

atcccgacca gaaggactct gacggtgagt catgggagcc actttctaag acagggactg    11760

ctggcacagc tgtgtagatt gaagaaatga aaccaaggct caaagcattt gacaggatga    11820

agggaccaaa tgccaactta gacaagatag tgacatttct gacaccagta ataataatag    11880

cactttagaa ttttgctgaa ctcttgcttt tttgacctca ggcgatggtc gaggtgatgc    11940

ctgcaaagat gattttgacc atgacagtgt gccagacatc gatgacatct gtcctgagaa    12000

tgttgacatc agtgagaccg atttccgccg attccagatg attcctctgg accccaaagg    12060

gacatcccaa aatgacccta actgggttgt acgccatcag ggtaaagaac tcgtccagac    12120

tgtcaactgt gatcctggac tcgctgtagg tgagtagcga gttcttagat cctaagagac    12180

tgatgcatac atggggaaaa acaaatataa aacctggcag ttgtacctat ccctgtgggt    12240

gctgaggatg tctaggaaca tgatggagaa ccttctgaag gctgcaggtt ttaacctggc    12300

tctgggctct tcttccaggt tatgatgagt ttaatgctgt ggacttcagt ggcaccttct    12360

tcatcaacac cgaaagggac gatgactatg ctggatttgt ctttggctac cagtccagca    12420

gccgctttta tgttgtgatg tggaagcaag tcacccagtc ctactgggac accaacccca    12480

cgagggctca gggatactcg ggcctttctg tgaaagttgt aaactccacc acagggcctg    12540

gcgagcacct gcggaacgcc ctgtggcaca caggaaacac ccctggccag gtaagaagca    12600

aagccctgga acagagagag agcttatggg tgcctgacta gcactgggga tgctgtgctt    12660

tgaccaagac tctgaccagg gagtcttaga aagttcccag catcaccagc tgcagcattg    12720

aactctgctt tgtaaaaaca taatagtgtt gaaaagggag cttgaccaag aattgccctg    12780

caaatcctaa ggtgccttca gccttttcaa acaaaaaaac ctccttccct cctctctgtc    12840

tgctttatat gtgtgctcag tggcacacaa caaatatgag aggacttgga aaaattcccc    12900

attgcagccc tctaacttag atcagctcag tacctttcaa gcattgtttc tgatggaatg    12960

aaatagaaat ctttacctga aggagctgtg tttcaacctt tccttttcct tttccttcag    13020

gtgcgcaccc tgtggcatga ccctcgtcac ataggctgga aagatttcac cgcctacaga    13080

tggcgtctca gccacaggcc aaagacgggt ttcattaggt acgatcatac tgattcactt    13140

tcacttacag tcacactgag ggacaaaaag acaaaaagta ttaaatagca ttgtcactaa    13200

acaagatttt ttttccctgc agagtggtga tgtatgaagg gaagaaaatc atggctgact    13260

caggacccat ctatgataaa acctatgctg gtggtagact agggttgttt gtcttctctc    13320

aagaaatggt gttcttctct gacctgaaat acgaatgtag aggtaagagc aacatcacca    13380

tgaatgtaca ctggacatct ctatttcaga ctaatatcaa ggatgacggt tatgggggag    13440

tccagtgtaa agactgtttt ggagacaggg ttatttctat tttgcttttg aggacacaag    13500

gacaaaaatg gaataatgcc taggcactgt ggcttatgag ttcctgagtc cttagctata    13560

atattagttt gcttagcaat ctctgtgctc ctcatacaca gtgcaaaggt aagctgcaga    13620

aaagctccta tataatttgg acttcattaa taatactgtt ctttacaatt atatatttat    13680

atatcttact gcttattgtt ttatgcatgc catcacagca cgagttagca ttcccaactt    13740

ttccctgtat acaaagaagg gagaggaatg ttgctttcat attggcatgt taaattaatg    13800

ttcactatta aacttagcat tttttttcct cattcttttt tacttagtca ttacttaagc    13860

tcgctgagtc caacactggc tctaccacaa aataagtgct taatatatat ttactgggcc    13920

aaggccagat acctaaaaga tcaatgacag tagagaaaga tggttgattt tactcaaaaa    13980

aatctaaatt attaatgtaa tttttgagtc caaattttta aaataagact ccctaaactg    14040

ttaacattga aagcctttgg aaagcataat atatgttctg gaaggttcac gctgtgtcgg    14100

tctcctagca tcaatgtcag ctaataaaat taaatgctaa tgtgcttgaa caaccttaaa    14160

attaggcttt tgtcattaga aaagtagagc tattcctatg tggttaactt attaactaag    14220

atgtctatgc ttttatgaat tagttttcat ttgtatattt atttatattt gtttatttaa    14280

cagatcccta atcatcaaat tgttgattga aagactgatc ataaaccaat gctggtattg    14340

caccttctgg aactatgggc ttgagaaaac ccccaggatc acttctcctt ggcttccttc    14400

ttttctgtgc ttgcatcagt gtggactcct agaacgtgcg acctgcctca agaaaatgca    14460

gttttcaaaa acagactcag cattcagcct ccaatgaata agacatcttc caagcatata    14520

aacaattgct ttggtttcct tttgaaaaag catctacttg cttcagttgg gaaggtgccc    14580

attccactct gcctttgtca cagagcaggg tgctattgtg aggccatctc tgagcagtgg    14640

actcaaaagc attttcaggc atgtcagaga agggaggact cactagaatt agcaaacaaa    14700

accaccctga catcctcctt caggaacacg gggagcagag gccaaagcac taaggggagg    14760

gcgcataccc gagacgattg tatgaagaaa atatggagga actgttacat gttcggtact    14820

aagtcatttt caggggattg aaagactatt gctggatttc atgatgctga ctggcgttag    14880

ctgattaacc catgtaaata ggcacttaaa tagaagcagg aaagggagac aaagactggc    14940

ttctggactt cctccctgat ccccaccctt actcatcacc tgcagtggcc agaattaggg    15000

aatcagaatc aaaccagtgt aaggcagtgc tggctgccat tgcctggtca cattgaaatt    15060

ggtggcttca ttctagatgt agcttgtgca gatgtagcag gaaaatagga aaacctacca    15120

tctcagtgag caccagctgc ctcccaaagg aggggcagcc gtgcttatat ttttatggtt    15180

acaatggcac aaaattatta tcaacctaac taaaacattc cttttctctt ttttcctgaa    15240

ttatcatgga gttttctaat tctctctttt ggaatgtaga ttttttttaa atgctttacg    15300

atgtaaaata tttatttttt acttattctg gaagatctgg ctgaaggatt attcatggaa    15360

caggaagaag cgtaaagact atccatgtca tctttgttga gagtcttcgt gactgtaaga    15420

ttgtaaatac agattattta ttaactctgt tctgcctgga aatttaggct tcatacggaa    15480

agtgtttgag agcaagtagt tgacatttat cagcaaatct cttgcaagaa cagcacaagg    15540

aaaatcagtc taataagctg ctctgcccct tgtgctcaga gtggatgtta tgggattctt    15600

tttttctctg ttttatcttt tcaagtggaa ttagttggtt atccatttgc aaatgtttta    15660

aattgcaaag aaagccatga ggtcttcaat actgttttac cccatccctt gtgcatattt    15720

ccagggagaa ggaaagcata tacacttttt tctttcattt ttccaaaaga gaaaaaaatg    15780

acaaaaggtg aaacttacat acaaatatta cctcatttgt tgtgtgactg agtaaagaat    15840

ttttggatca agcggaaaga gtttaagtgt ctaacaaact taaagctact gtagtaccta    15900

aaaagtcagt gttgtacata gcataaaaac tctgcagaga agtattccca ataaggaaat    15960

agcattgaaa tgttaaatac aatttctgaa agttatgttt tttttctatc atctggtata    16020

ccattgcttt atttttataa attattttct cattgccatt ggaatagata tctcagattg    16080

tgtagatatg ctatttaaat aatttatcag gaaatactgc ctgtagagtt agtatttcta    16140

tttttatata atgtttgcac actgaattga agaattgttg gttttttctt ttttttgttt    16200

tgtttttttt tttttttttt tttgcttttg acctcccatt tttactattt gccaatacct    16260

ttttctagga atgtgctttt ttttgtacac atttttatcc attttacatt ctaaagcagt    16320

gtaagttgta tattactgtt tcttatgtac aaggaacaac aataaatcat atggaaattt    16380

atatttata                                                            16389


<210> 2
<211> 1170
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210> 3
<211> 1001
<212> DNA
<213> Homo sapiens

<400> 3
gttttaaagt gtggggggcg caagaccaac aatttggggg cttttgggaa gtcgaaggtg       60

agcaagatca ggaactgtag tttggggttg cagggagggc aggggaagta cagactcttc      120

cctggagtgc tgatacaaag gcttaaggag gacttcagag agtaaggaaa tcttggggtg      180

tcctgatgag ttggtttgtg aacctcaagg ctggagagga tggctctgga gccttgccct      240

gaagagtcct ccagcggctg agaggagcgg gctggggtag gcgagcgggg agagtgtagg      300

ttccggggtc caccagaggg actgaagcct cagcgctcca ggtggatgtc ccgggcagct      360

ttggtcctcg gcggccgccg ggggcgactt acctgtgtgt accggagcgc ggcggccggg      420

agcggtggcg agggcggcga gggctggagg ggcgcgggga atgcctgtgc gtccggagta      480

gaggttgctc ctggagagcg rcaggagccc tgaactcgca ggccagctcg ggcgcagcgg      540

ctggcaaggc ggaggagccg cgcgctttta aaggggcgct cgcattcctg gggattcctc      600

cggccaatgg gcggcggccg ggcaggaagc gggaggtggg ggccagtctg ggctcctctc      660

tccgcccccc gctgcctggc gcgcaacttt ccagctagaa agtgaagggg gcgggggtcg      720

gggcttggga gcactagaac ttctcagaaa agtcggtgcc cgcccacgca gccttggcgc      780

gcacgggctc ggcgctcgta ctcttgcgcc acgcgggctc ggggtgatca gcaagcatcc      840

cgaaaaggga cggggctggg gagaccacct aggagggccc gcggggtggc gcaggggctt      900

tcgggcgagc tgatctcccg gaatgcctgg ttgatggcga gaggtggata ctagagactg      960

ggcccgtttt gtaaaaagaa aaatgggccg acggggcgca g                         1001


<210> 4
<211> 1001
<212> DNA
<213> Homo sapiens

<400> 4
acccttgaac acaacttacc ctctctgagg ctctttcctc atttgcaact tggagataat       60

aatagttctt gataagttta tcttgagcat tttatttaga tactgcatgt aaagcagtta      120

gcactgagtt ttggtttatg gtaagcaccc tgtaaatgtt aggatattaa cagcaaccca      180

taaaaacagc gaacttatcc gttctctggt agaaaacatt ccatgttgac atttgggcat      240

gtggccagga gccaatttct accgtacact gggtttagtt gccattgacc atttcctgga      300

aatacttctg cgtgctcctg atgggagcct ctatttggct gtctctaagc caaaaccatt      360

tgtgaccatc aactctgtac tttagttaaa caggatggtg gctggagcca ctggtccccg      420

tggtcatctt gttctgtgac atgtggtgat ggtgtgatca caaggatccg gctctgcaac      480

tctcccagcc cccagatgaa ygggaaaccc tgtgaaggcg aagcgcggga gaccaaagcc      540

tgcaagaaag acgcctgccc cagtaagtgt gaggtccgct gcaagggtga gcatgggcag      600

cagctctgcc cagctggttg cctggcatct gcagcctgca gttcagtggg tcatagagca      660

ggaaggttac ctactagaga aacaaacaga agcaaagtcc tgcaggctca gcaacttctt      720

ttaatgaaaa acaaactcac cctcttcccc agcattcttt ccatgtgtca gagaagcaga      780

ggtttcttga acgggcttag gagagtctat gacaagggag ggatttgaaa gttgatctta      840

attgttgcct gtggttcatc ttcttacagt caatggaggc tggggtcctt ggtcaccatg      900

ggacatctgt tctgtcacct gtggaggagg ggtacagaaa cgtagtcgtc tctgcaacaa      960

ccccacaccc cagtttggag gcaaggactg cgttggtgat g                         1001


<210> 5
<211> 1001
<212> DNA
<213> Homo sapiens

<400> 5
agatccagaa actcggagcc ccatcagttc ctcacctcat caacatctgt gcactggatg       60

ccatttccac tgtaaccagg gggacaagca ccacatttcc agctgccatc agggtagcta      120

gtacacttca cgccggcaaa gcagggattg gacaggcatc catctgagac aaggagagag      180

agacagtcac agtaaatggt tggtctaagc tgccatactg ccatgctggg cacttaacac      240

agtgtaagat attatagggt atagggaacc gataacttgt tgggattatg ttgtccacct      300

gcatcttaga gcaatcaaat cgctcaggac taaccaagct ggaatctcct cgaatgctga      360

ctgcagcatt cagtaaaaga gcaaagctcc tgggtcgttt catcctgggc tgcgtggctc      420

accaattgga cagtcctgct tgttgcagat ctggttttct gttacatcac caacgcagtc      480

cttgcctcca aactggggtg yggggttgtt gcagagacga ctacgtttct gtacccctcc      540

tccacaggtg acagaacaga tgtcccatgg tgaccaagga ccccagcctc cattgactgt      600

aagaagatga accacaggca acaattaaga tcaactttca aatccctccc ttgtcataga      660

ctctcctaag cccgttcaag aaacctctgc ttctctgaca catggaaaga atgctgggga      720

agagggtgag tttgtttttc attaaaagaa gttgctgagc ctgcaggact ttgcttctgt      780

ttgtttctct agtaggtaac cttcctgctc tatgacccac tgaactgcag gctgcagatg      840

ccaggcaacc agctgggcag agctgctgcc catgctcacc cttgcagcgg acctcacact      900

tactggggca ggcgtctttc ttgcaggctt tggtctcccg cgcttcgcct tcacagggtt      960

tcccgttcat ctgggggctg ggagagttgc agagccggat c                         1001


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
ggactctgac ggcgatggtc                                                   20


<210> 7
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
atcggcggaa atcggtctc                                                    19


<210> 8
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
cggcatccag ctacgaatc                                                    19


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
ccatggccac aacaactgac                                                   20


<210> 10
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
cgggaaatcg tgcgtgac                                                     18


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
gtggccatct cttgctcgaa                                                   20


