                               SEQUENCE LISTING

<110> APELLIS PHARMACEUTICALS, INC.
 
<120> CELL-PENETRATING COMPSTATIN ANALOGS AND USES THEREOF

<130> 2008575-0078

<140> PCT/US2014/027289
<141> 2014-03-14

<150> 61/791,631
<151> 2013-03-15

<160> 139   

<170> PatentIn version 3.5

<210> 1
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<400> 1
Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210> 2
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(19)
<223> Any independently selected amino acid or amino
      acid analog

<220>
<221> misc_feature
<222> (1)..(19)
<223> This region may encompass 2 to 19 residues, wherein
      some residues may be absent

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Trp or an analog of Trp

<220>
<221> MOD_RES
<222> (24)..(42)
<223> Any independently selected amino acid or amino
      acid analog

<220>
<221> misc_feature
<222> (24)..(42)
<223> This region may encompass 2 to 19 residues, wherein
      some residues may be absent

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 2
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Trp, an analog of Trp, or other amino acid or amino acid
      analog comprising at least one aromatic ring 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Trp, an analog of Trp, or other amino acid or amino acid
      analog comprising at least one aromatic ring 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 3
Xaa Gln Asp Xaa Gly 
1               5   


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Trp, an analog of Trp, or other amino acid or amino acid 
      analog comprising at least one aromatic side chain 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Trp, an analog of Trp, or other amino acid or amino acid 
      analog comprising at least one aromatic side chain 

<220>
<221> MOD_RES
<222> (6)..(6)
<223> His, Ala, analog of Ala, Phe, Trp or analog of Trp

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 4
Xaa Gln Asp Xaa Gly Xaa 
1               5       


<210> 5
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> Any independently selected amino acid or amino
      acid analog

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Trp or analog of Trp

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Trp or analog of Trp

<220>
<221> MOD_RES
<222> (9)..(13)
<223> Any independently selected amino acid or amino
      acid analog

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 5
Xaa Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Ile, Val, Leu, B1-Ile, B1-Val, B1-Leu or a dipeptide 
      comprising Gly-Ile or B1-Gly-Ile, wherein B1 represents 
      a first blocking moiety 

<220>
<221> misc_feature
<222> (1)..(2)
<223> This region may encompass 1 to 2 residues, wherein some
      positions may be absent

<220>
<221> misc_feature
<222> (3)..(13)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Independently selected from Trp or analogs of Trp

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Independently selected from Trp or analogs of Trp

<220>
<221> MOD_RES
<222> (10)..(10)
<223> His, Ala or an analog of Ala, Phe, Trp or an analog 
      of Trp 

<220>
<221> MOD_RES
<222> (14)..(16)
<223> L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala
      or Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein
      a C-term -OH of any of the L-Thr, D-Thr, Ile, Val, Gly,
      Ala or Asn is optionally replaced by a second blocking moiety 

<220>
<221> misc_feature
<222> (14)..(16)
<223> This region may encompass 1 to 3 residues, wherein some
      positions may be absent 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 6
Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa Xaa 
1               5                   10                  15      


<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Ile, Val, Leu, Ac-Ile, Ac-Val, Ac-Leu or a dipeptide
      comprising Gly-Ile or Ac-Gly-Ile

<220>
<221> misc_feature
<222> (1)..(2)
<223> This region may encompass 1 to 2 residues, wherein some
      positions may be absent

<220>
<221> misc_feature
<222> (3)..(13)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Independently selected from Trp or analogs of Trp 

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Independently selected from Trp or analogs of Trp 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> His, Ala or an analog of Ala, Phe, Trp or an analog
      of Trp 

<220>
<221> MOD_RES
<222> (14)..(16)
<223> L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala
      or Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein a
      C-term -OH of any of L-Thr, D-Thr, Ile, Val, Gly, Ala, or Asn
      is optionally replaced by -NH2

<220>
<221> misc_feature
<222> (14)..(16)
<223> This region may encompass 1 to 3 residues, wherein some
      positions may be absent 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 7
Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa Xaa 
1               5                   10                  15      


<210> 8
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term H

<220>
<223> C-term CONH2

<400> 8
Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210> 9
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<223> C-term CONH2

<400> 9
Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210> 10
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<223> C-term CONH2

<400> 10
Ile Cys Val Tyr Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 11
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<223> C-term COOH

<400> 11
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 12
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<223> C-term CONH2

<400> 12
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 13
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (13)..(13)
<223> D-Thr

<220>
<223> C-term COOH

<400> 13
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 2-Nal

<220>
<223> C-term CONH2

<400> 14
Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 15
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 2-Nal

<220>
<223> C-term COOH

<400> 15
Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 16
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 1-Nal

<220>
<223> C-term COOH

<400> 16
Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 17
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 2-Igl

<220>
<223> C-term CONH2

<400> 17
Ile Cys Val Gly Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 2-Igl

<220>
<223> C-term COOH

<400> 18
Ile Cys Val Gly Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 19
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Dht

<220>
<223> C-term COOH

<400> 19
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 20
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Bpa

<220>
<223> C-term COOH

<400> 20
Ile Cys Val Phe Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 21
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Bpa

<220>
<223> C-term CONH2

<400> 21
Ile Cys Val Phe Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 22
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Bta

<220>
<223> C-term COOH

<400> 22
Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 23
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Bta

<220>
<223> C-term CONH2

<400> 23
Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 24
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (9)..(9)
<223> 2-Abu

<220>
<223> C-term CONH2

<400> 24
Ile Cys Val Trp Gln Asp Trp Gly Xaa His Arg Cys Thr 
1               5                   10              


<210> 25
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term H

<220>
<223> C-term COOH

<400> 25
Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Ala Asn 
1               5                   10                  15      


<210> 26
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 5f-Trp

<220>
<223> C-term CONH2

<400> 26
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 27
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 5-methyl-Trp

<220>
<223> C-term CONH2

<400> 27
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 28
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 1-methyl-Trp

<220>
<223> C-term CONH2

<400> 28
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 29
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (7)..(7)
<223> 5f-Trp

<220>
<223> C-term CONH2

<400> 29
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 30
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 5f-Trp

<220>
<221> MOD_RES
<222> (7)..(7)
<223> 5f-Trp

<220>
<223> C-term CONH2

<400> 30
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 31
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 5-methyl-Trp

<220>
<221> MOD_RES
<222> (7)..(7)
<223> 5f-Trp

<220>
<223> C-term CONH2

<400> 31
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 32
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 1-methyl-Trp

<220>
<221> MOD_RES
<222> (7)..(7)
<223> 5f-Trp

<220>
<223> C-term CONH2

<400> 32
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 33
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term H

<220>
<221> MOD_RES
<222> (5)..(5)
<223> 6f-Trp

<220>
<221> MOD_RES
<222> (8)..(8)
<223> 6f-Trp

<220>
<223> C-term COOH

<400> 33
Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Asn 
1               5                   10                  15  


<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 1-formyl-Trp

<220>
<223> C-term CONH2

<400> 34
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 35
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 1-methoxy-Trp

<220>
<223> C-term CONH2

<400> 35
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term H

<220>
<221> MOD_RES
<222> (5)..(5)
<223> 5f-Trp

<220>
<221> MOD_RES
<222> (8)..(8)
<223> 5f-Trp

<220>
<223> C-term COOH

<400> 36
Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Asn 
1               5                   10                  15  


<210> 37
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp  

<400> 37
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 38
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)5-C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 38
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 39
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term (C=O)-(CH2)5-maleimide 

<400> 39
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 40
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2O
      CH2CH2C(=O)

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 40
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 41
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 41
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)3-C(=O)-NH-CH2CH2OCH2CH2
      OCH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 42
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 43
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)5-C(=O)-NH-CH2CH2OCH2CH2
      OCH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 43
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 44
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)4-C(=O)-NH-CH2CH2OCH2CH2
      OCH2CH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 44
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 45
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2
      OCH2CH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 45
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 46
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)5-C(=O)-NH-CH2CH2OCH2CH2
      OCH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 46
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 47
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 47
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 48
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 48
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
        


<210> 49
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term NH2(CH2)5C(=O) 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 49
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 50
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term NH2(CH2CH2O)2CH2C(=O) 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 50
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 51
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys 

<220> 
<223> C-term NH2 

<400> 51
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 52
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (14)..(14)
<223> Lys-(C(=O)-(CH2)5-Mal) 

<220> 
<223> C-term NH2 

<400> 52
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 53
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (19)..(19)
<223> Lys-(C(=O)-(CH2)5-Mal) 

<220> 
<223> C-term NH2 

<400> 53
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
            


<210> 54
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Mal-(CH2)5-(C(=O)-NH(CH2)5C(=O) 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 54
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 55
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Mal-(CH2)5-(C(=O)NH(CH2CH2O)2CH2C(=O) 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 55
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 56
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)5-Mal) 

<220> 
<223> C-term NH2 

<400> 56
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 57
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (14)..(14)
<223> Lys-C(=O)-CH2(OCH2CH2)2NH(C(=O)-(CH2)5-Mal) 

<220> 
<223> C-term NH2 

<400> 57
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 58
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term (CH2CH2O)nC(=O)

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 58
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 59
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-C(=O)-(CH2CH2O)n

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 59
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 60
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Lys-C(=O)-(CH2CH2O)n

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 60
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 61
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Lys-C(=O)-(CH2CH2O)n

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 61
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
            


<210> 62
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (1)..(1)
<223> (CH2CH2O)nC(=O)Lys

<220>
<221> misc_feature
<222> (8)..(18)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (10)..(10)
<223> (1Me)Trp

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 62
Lys Gly Gly Gly Gly Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His 
1               5                   10                  15      


Arg Cys Thr 
            


<210> 63
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (1)..(1)
<223> (CH2CH2O)nC(=O)Lys

<220>
<221> misc_feature
<222> (3)..(13)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> (1Me)Trp

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 63
Lys Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10                  


<210> 64
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2CH2O)n-R)

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 64
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 65
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m-
      (CH2CH2O)n-R)

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 65
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 66
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m-C(=O)-
     (CH2CH2O)n-R)

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 66
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 67
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m-C(=O)
      -(CH2)j(CH2CH2O)n-R) 

<220> 
<223> C-term NH2 

<400> 67
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 68
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term H

<220>
<221> MOD_RES
<222> (1)..(3) 
<223> D-Arg

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> D-Gln

<220>
<221> MOD_RES
<222> (5)..(6) 
<223> D-Arg

<220>
<221> MOD_RES
<222> (7)..(8) 
<223> D-Lys

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> D-Arg

<220>
<221> misc_feature
<222> (9)..(10) 
<223> Residues at these positions are linked by an AEEAc moiety

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> (1Me)Trp  

<220>
<223> C-term NH2

<400> 68
Arg Arg Arg Gln Arg Arg Lys Lys Arg Ile Cys Val Trp Gln Asp Trp 
1               5                   10                  15      


Gly Ala His Arg Cys Thr 
            20          


<210> 69
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (12)..(13) 
<223> Residues at these positions are linked by an AEEAc moiety

<220> 
<221> misc_feature
<222> (14)..(24)
<223> Disulfide bond 

<220>
<221> MOD_RES
<222> (16)..(16) 
<223> (1Me)Trp  

<220>
<223> C-term NH2

<400> 69
Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala Gly Ile Cys Val Trp 
1               5                   10                  15      


Gln Asp Trp Gly Ala His Arg Cys Thr 
            20                  25  


<210> 70
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (16)..(17) 
<223> Residues at these positions are linked by an AEEAc moiety

<220> 
<221> misc_feature
<222> (18)..(28)
<223> Disulfide bond 

<220>
<221> MOD_RES
<222> (20)..(20) 
<223> (1Me)Trp  

<220>
<223> C-term NH2

<400> 70
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
            20                  25                  


<210> 71
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 71
His His His His His His 
1               5       


<210> 72
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(4)
<223> Any independently selected amino acid or amino
      acid analog

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Trp or analog of Trp

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Trp or analog of Trp

<220>
<221> MOD_RES
<222> (10)..(14)
<223> Any independently selected amino acid or amino
      acid analog

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 72
Xaa Xaa Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210> 73
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(3)
<223> Ile, Val, Leu, B1-Ile, B1-Val, B1-Leu or a dipeptide 
      comprising Gly-Ile or B1-Gly-Ile, wherein B1 represents 
      a first blocking moiety 

<220>
<221> misc_feature
<222> (2)..(3)
<223> This region may encompass 1 to 2 residues, wherein some
      positions may be absent

<220>
<221> misc_feature
<222> (4)..(14)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Independently selected from Trp or analogs of Trp

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Independently selected from Trp or analogs of Trp

<220>
<221> MOD_RES
<222> (11)..(11)
<223> His, Ala or an analog of Ala, Phe, Trp or an analog 
      of Trp 

<220>
<221> MOD_RES
<222> (15)..(17)
<223> L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala
      or Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein
      a C-term -OH of any of the L-Thr, D-Thr, Ile, Val, Gly,
      Ala or Asn is optionally replaced by a second blocking moiety 

<220>
<221> misc_feature
<222> (15)..(17)
<223> This region may encompass 1 to 3 residues, wherein some
      positions may be absent 

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 73
Xaa Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210> 74
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Ile or Gly

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Ile or Cys

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Val or Cys
     
<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Val, Tyr, Trp, 2-Nal, 1-Nal, 2-Igl, Dht, Bpa, Bta,  
      5f-Trp, 5-methyl-Trp, 1-methyl-Trp, 1-formyl-Trp or 
      1-methyoxy-Trp

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gln, Trp, 6f-Trp or 5f-Trp

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Asp or Gln

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Trp, Asp or 5f-Trp

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Gly, Trp, 6f-Trp or 5f-Trp

<220>
<221> MOD_RES
<222> (10)..(10) 
<223> His, Ala, 2-Abu or Gly

<220>
<221> MOD_RES
<222> (11)..(11) 
<223> His or Ala

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Arg or His

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Cys or Arg

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Thr, D-Thr or Cys

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 74
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210> 75
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> misc_feature
<222> (3)..(13)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Trp(Me)

<220>
<221> MOD_RES
<222> (9)..(9)
<223> mGly

<220>
<221> MOD_RES
<222> (14)..(14)
<223> mIle

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 75
Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile Xaa 
1               5                   10                  15  


<210> 76
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> misc_feature
<222> (3)..(13)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Trp(Me)

<220>
<221> MOD_RES
<222> (9)..(9)
<223> mGly

<220>
<221> MOD_RES
<222> (14)..(14)
<223> mIle

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 76
Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile Xaa 
1               5                   10                  15  



<210> 77
<211> 13
<212> PRT
<213> Human immunodeficiency virus

<400> 77
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210> 78
<211> 17
<212> PRT
<213> Human immunodeficiency virus

<400> 78
Gly Ile Ser Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro 
1               5                   10                  15      


Gln 
    


<210> 79
<211> 23
<212> PRT
<213> Human immunodeficiency virus

<400> 79
Phe Ile Thr Lys Ala Leu Gly Ile Ser Tyr Gly Arg Lys Lys Arg Arg 
1               5                   10                  15      


Gln Arg Arg Arg Pro Pro Gln 
            20              


<210> 80
<211> 10
<212> PRT
<213> Human immunodeficiency virus

<400> 80
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210> 81
<211> 9
<212> PRT
<213> Human immunodeficiency virus

<400> 81
Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210> 82
<211> 8
<212> PRT
<213> Human immunodeficiency virus

<400> 82
Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210> 83
<211> 9
<212> PRT
<213> Human immunodeficiency virus


<220>
<221> MOD_RES
<222> (1)..(9) 
<223> D-amino acid

<400> 83
Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210> 84
<211> 9
<212> PRT
<213> Human immunodeficiency virus

<400> 84
Arg Arg Arg Gln Arg Arg Lys Lys Arg 
1               5                   


<210> 85
<211> 9
<212> PRT
<213> Human immunodeficiency virus


<220>
<221> MOD_RES
<222> (1)..(9) 
<223> D-amino acid

<400> 85
Arg Arg Arg Gln Arg Arg Lys Lys Arg 
1               5                   


<210> 86
<211> 9
<212> PRT
<213> Human immunodeficiency virus

<400> 86
Arg Lys Lys Arg Arg Ala Arg Arg Arg 
1               5                   


<210> 87
<211> 11
<212> PRT
<213> Human immunodeficiency virus

<400> 87
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys 
1               5                   10      


<210> 88
<211> 17
<212> PRT
<213> Human immunodeficiency virus

<400> 88
Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln 
1               5                   10                  15      


Arg 
    


<210> 89
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      galanin polypeptide

<400> 89
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val 
1               5                   10                  15      


Gly Asn His Arg Ser Phe Ser Asp Lys Asn Gly Leu Thr Ser 
            20                  25                  30  


<210> 90
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MP Wasp venom peptide Mastoparan

<400> 90
Ile Asn Leu Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
1               5                   10                  


<210> 91
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 91
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 92
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 92
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 93
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 93
Lys Lys Trp Lys Met Arg Arg Asn Gln Phe Trp Ile Lys Ile Gln Arg 
1               5                   10                  15      


<210> 94
<211> 16
<212> PRT
<213> Drosophila sp.


<220>
<221> MOD_RES
<222> (1)..(16) 
<223> D-amino acid

<400> 94
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 95
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 95
Arg Gln Ile Lys Ile Trp Phe Pro Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 96
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 96
Arg Gln Pro Lys Ile Trp Phe Pro Asn Arg Arg Lys Pro Trp Lys Lys 
1               5                   10                  15      


<210> 97
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 97
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 98
<211> 15
<212> PRT
<213> Drosophila sp.

<400> 98
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15  


<210> 99
<211> 14
<212> PRT
<213> Drosophila sp.

<400> 99
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  


<210> 100
<211> 14
<212> PRT
<213> Drosophila sp.

<400> 100
Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  


<210> 101
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 101
Arg Gln Ile Lys Ile Trp Phe Pro Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 102
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PTD4 peptide

<400> 102
Arg Ala Ala Ala Arg Gln Ala Arg Ala Gly 
1               5                   10  


<210> 103
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PTD4 peptide

<400> 103
Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala Gly 
1               5                   10          


<210> 104
<211> 13
<212> PRT
<213> Crotalus sp.

<400> 104
Lys Met Asp Cys Arg Trp Arg Trp Lys Cys Cys Lys Lys 
1               5                   10              


<210> 105
<211> 16
<212> PRT
<213> Homo sapiens

<400> 105
Arg Lys Lys Arg Arg Arg Glu Ser Arg Lys Lys Arg Arg Arg Glu Ser 
1               5                   10                  15      


<210> 106
<211> 17
<212> PRT
<213> Homo sapiens

<400> 106
Gly Arg Pro Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu Lys 
1               5                   10                  15      


Pro 
    


<210> 107
<211> 15
<212> PRT
<213> Homo sapiens

<400> 107
Gly Lys Arg Lys Lys Lys Gly Lys Leu Gly Lys Lys Arg Asp Pro 
1               5                   10                  15  


<210> 108
<211> 19
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      DPV10/6 peptide

<400> 108
Ser Arg Arg Ala Arg Arg Ser Pro Arg Glu Ser Gly Lys Lys Arg Lys 
1               5                   10                  15      


Arg Lys Arg 
            


<210> 109
<211> 5
<212> PRT
<213> Homo sapiens

<400> 109
Val Pro Met Leu Lys 
1               5   


<210> 110
<211> 5
<212> PRT
<213> Homo sapiens

<400> 110
Lys Leu Pro Val Met 
1               5   


<210> 111
<211> 22
<212> PRT
<213> Mycobacterium sp.

<400> 111
Thr Lys Arg Arg Ile Thr Pro Lys Asp Val Ile Asp Val Arg Ser Val 
1               5                   10                  15      


Thr Thr Glu Ile Asn Thr 
            20          


<210> 112
<211> 26
<212> PRT
<213> Mycobacterium sp.

<400> 112
Ala Glu Lys Val Asp Pro Val Lys Leu Asn Leu Thr Leu Ser Ala Ala 
1               5                   10                  15      


Ala Glu Ala Leu Thr Gly Leu Gly Asp Lys 
            20                  25      


<210> 113
<211> 22
<212> PRT
<213> Mycobacterium sp.

<400> 113
Thr Lys Arg Arg Ile Thr Pro Lys Asp Val Ile Asp Val Arg Ser Val 
1               5                   10                  15      


Thr Thr Lys Ile Asn Thr 
            20          


<210> 114
<211> 29
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Res1 L3 loop of restrictocin peptide

<400> 114
Lys Leu Ile Lys Gly Arg Thr Pro Ile Lys Phe Gly Lys Ala Asp Cys 
1               5                   10                  15      


Asp Arg Pro Pro Lys His Ser Gln Asn Gly Met Gly Lys 
            20                  25                  


<210> 115
<211> 37
<212> PRT
<213> Human respiratory syncytial virus

<400> 115
Lys Arg Ile Pro Asn Lys Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro 
1               5                   10                  15      


Thr Lys Lys Pro Thr Ile Lys Thr Thr Lys Lys Asp Leu Lys Pro Gln 
            20                  25                  30          


Thr Thr Lys Pro Lys 
        35          


<210> 116
<211> 22
<212> PRT
<213> Human immunodeficiency virus

<400> 116
Asp Arg Arg Arg Arg Gly Ser Arg Pro Ser Gly Ala Glu Arg Arg Arg 
1               5                   10                  15      


Arg Arg Ala Ala Ala Ala 
            20          


<210> 117
<211> 25
<212> PRT
<213> Homo sapiens

<400> 117
Gly Thr Lys Met Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala 
1               5                   10                  15      


Asp Leu Ile Ala Tyr Leu Lys Lys Ala 
            20                  25  


<210> 118
<211> 17
<212> PRT
<213> Flock house virus

<400> 118
Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg Gly 
1               5                   10                  15      


Cys 
    


<210> 119
<211> 11
<212> PRT
<213> Homo sapiens

<400> 119
Met Ile Ile Tyr Arg Asp Leu Ile Ser Lys Lys 
1               5                   10      


<210> 120
<211> 10
<212> PRT
<213> Homo sapiens

<400> 120
Met Ile Ile Tyr Arg Asp Lys Lys Ser His 
1               5                   10  


<210> 121
<211> 10
<212> PRT
<213> Homo sapiens

<400> 121
Met Ile Ile Phe Arg Asp Leu Ile Ser His 
1               5                   10  


<210> 122
<211> 10
<212> PRT
<213> Homo sapiens

<400> 122
Met Ile Ile Tyr Arg Asp Leu Ile Ser His 
1               5                   10  


<210> 123
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 123
Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210> 124
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 124
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 125
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(6) 
<223> D-amino acid

<400> 125
Arg Arg Arg Arg Arg Arg
1               5   


<210> 126
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(7) 
<223> D-amino acid

<400> 126
Arg Arg Arg Arg Arg Arg Arg 
1               5           


<210> 127
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(8) 
<223> D-amino acid

<400> 127
Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210> 128
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(9) 
<223> D-amino acid

<400> 128
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 129
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      transportan (TP) peptide

<400> 129
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210> 130
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 130
Ala Leu Trp Lys Thr Leu Leu Lys Lys Val Leu Lys Ala Pro Lys Lys 
1               5                   10                  15      


Lys Arg Lys Val 
            20  


<210> 131
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 131
Glu Glu Glu Ala Ala Gly Arg Lys Arg Lys Lys Arg Thr 
1               5                   10              


<210> 132
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 132
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210> 133
<211> 18
<212> PRT
<213> Homo sapiens

<400> 133
Gly Leu Arg Arg Leu Arg Gln Arg Arg Arg Leu Arg Arg Glu Arg Val 
1               5                   10                  15      


Arg Ala 
        


<210> 134
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 134
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 135
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 135
Lys Trp Lys Leu Phe Lys Lys Ile Gly Ala Val Leu Lys Val Leu 
1               5                   10                  15  


<210> 136
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 136
Lys Lys Leu Phe Lys Lys Ile Leu Lys Tyr Leu 
1               5                   10      


<210> 137
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> C-term NH2

<400> 137
Lys Trp Lys Leu Phe Lys Lys Ile Gly Ala Val Leu Lys Val Leu 
1               5                   10                  15  


<210> 138
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> C-term NH2

<400> 138
Lys Lys Leu Phe Lys Lys Ile Leu Lys Tyr Leu 
1               5                   10      


<210> 139
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> (1Me)Trp  

<220>
<221> misc_feature
<222> (13)..(14) 
<223> Residues at these positions are linked by an AEEAc moiety

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Lys-(C(=O)-(CH2)5-Mal)

<220>
<223> C-term NH2

<400> 139
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


