                         SEQUENCE LISTING

<110>  Beth Israel Deaconess Medical Center, Inc.
 
<120>  METHODS AND COMPOSITIONS FOR THE GENERATION AND USE OF 
       CONFORMATION-SPECIFIC ANTIBODIES

<130>  01948-226WO2

<140>  PCT/US2014/027017
<141>  2014-03-14

<150>  61/792,588
<151>  2013-03-15

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  1

Ser Tyr Trp Ile His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  2

Val Ile Asp Pro Ser Asp Ser Tyr Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  3

Trp Glu Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  4

Arg Ser Ser Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  7
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  7

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  8
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  8

Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  9
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  9

Leu Arg Arg Asp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
1               5                   10                  15      


Ala 
    


<210>  10
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  10

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  11

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  13

Asp Thr Tyr Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  14

Arg Ile Asp Pro Ala Asn Gly Asn Thr Arg Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  15

Arg Val Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
1               5                   10                  15      


Val Ser Ser 
            


<210>  16
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  16

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asp Leu Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  17
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  17

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  18
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  18

His Gln Tyr Leu Ser Ser Tyr Thr 
1               5               


<210>  19
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  19

Lys Ser Ser Gln Ser Leu Leu Tyr Thr Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  20
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  20

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  21

Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210>  22
<211>  163
<212>  PRT
<213>  Mus musculus

<400>  22

Met Gly Val Ser Leu Gln Leu Leu Gly Thr Gln Asp Leu Thr Met Arg 
1               5                   10                  15      


Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly Val Asn 
            20                  25                  30          


Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly 
        35                  40                  45              


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
    50                  55                  60                  


Tyr Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
65                  70                  75                  80  


Ile Gly Val Ile Asp Pro Ser Asp Ser Tyr Thr Arg Tyr Asn Gln Lys 
                85                  90                  95      


Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala 
            100                 105                 110         


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
        115                 120                 125             


Cys Thr Thr Trp Glu Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
    130                 135                 140                 


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
145                 150                 155                 160 


Gly Ser Leu 
            


<210>  23
<211>  166
<212>  PRT
<213>  Mus musculus

<400>  23

Met Gly Thr Asp Gln Ser Pro Gln Ala Val Ser Ser Gly Cys Leu Leu 
1               5                   10                  15      


Lys Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro 
            20                  25                  30          


Ala Ser Asn Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro 
        35                  40                  45              


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
    50                  55                  60                  


Leu Val His Ser Asp Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys 
65                  70                  75                  80  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
                85                  90                  95      


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
            100                 105                 110         


Thr Leu Lys Ile Ser Arg Leu Glu Ala Glu Asp Leu Gly Val Tyr Phe 
        115                 120                 125             


Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
145                 150                 155                 160 


Pro Ser Ser Lys Leu Gly 
                165     


<210>  24
<211>  149
<212>  PRT
<213>  Mus musculus

<400>  24

Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Gly Leu Arg Arg Asp Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
    130                 135                 140                 


Ala Pro Gly Ser Leu 
145                 


<210>  25
<211>  145
<212>  PRT
<213>  Mus musculus

<400>  25

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Lys Leu 
    130                 135                 140                 


Gly 
145 


<210>  26
<211>  152
<212>  PRT
<213>  Mus musculus

<400>  26

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Thr Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Arg Tyr Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ser Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Val Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Val Pro Gly Ser Leu 
145                 150         


<210>  27
<211>  148
<212>  PRT
<213>  Mus musculus

<400>  27

Met Glu Ser Gln Thr Gln Val Phe Leu Ser Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asp Leu Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Thr Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys His Gln Tyr Leu Ser Ser Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Lys 
145             


<210>  28
<211>  151
<212>  PRT
<213>  Mus musculus

<400>  28

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Thr Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Lys Leu Gly 
145                 150     


<210>  29
<211>  491
<212>  DNA
<213>  Mus musculus

<400>  29
atgggggtct ctctacagtt actaggcaca caggatctca ccatgagatg gagctgtatc       60

atcctcttct tggtagcaac agctacaggt gtcaactccc aggtccaact gcagcagcct      120

ggggctgagc tggtgaagcc tggggcttca gtgaagatgt cctgcaaggc ttctggctac      180

accttcacca gctactggat acactgggtg aagcagaggc ctggacaagg ccttgagtgg      240

atcggagtga ttgatccttc tgatagttat actaggtaca atcaaaagtt caagggcaag      300

gccacgttga ctgtagacac atcctccagc acagcctaca tgcaactcag cagcctgaca      360

tctgaggact ctgcggtcta ttactgtaca acatgggagg ttgactactg gggccaaggc      420

accactctca cagtctcctc agccaaaaca acacccccat cagtctatcc cctggcccct      480

ggaagcttgg g                                                           491


<210>  30
<211>  498
<212>  DNA
<213>  Mus musculus

<400>  30
atggggactg atcagtctcc tcaggctgtc tcctcaggtt gcctcctcaa aatgaagttg       60

cctgttaggc tgttggtgct gatgttctgg attcctgctt ccaacagtga tgttgtgatg      120

acccaaactc cactctccct gcctgtcagt cttggagatc aagcctccat ctcttgcaga      180

tctagtcaga gccttgtcca cagtgatgga aacacctatt tacattggta cctgcagaag      240

ccaggccagt ctccaaagct cctgatctac aaagtttcca accgattttc tggggtccca      300

gacaggttca gtggcagtgg atcagggaca gatttcacac tcaagatcag cagactggag      360

gctgaggatc tgggagttta tttctgctct caaagtacac atgttccgtg gacgttcggt      420

ggaggcacca agctggaaat caaacgggct gatgctgcac caactgtatc catcttccca      480

ccatccagta agcttggg                                                    498


<210>  31
<211>  449
<212>  DNA
<213>  Mus musculus

<400>  31
atgaaagtgt tgagtctgtt gtacctgttg acagccattc ctggtatcct gtctgatgta       60

cagcttcagg agtcaggacc tggcctcgtg aaaccttctc agtctctgtc tctcacctgc      120

tctgtcactg gctactccat caccagtggt tattactgga actggatccg gcagtttcca      180

ggaaacaaac tggaatggat gggctacata agctacgacg gtagcaataa ctacaaccca      240

tctctcaaaa atcgaatctc catcactcgt gacacatcta agaaccagtt tttcctgaag      300

ttgaattctg tgactactga ggacacagct acatattact gtgcggggtt acgacgtgat      360

gcttactggg gccaagggac tctggtcact gtctctgcag ccaaaacaac acccccatca      420

gtctatccac tggcccctgg aagcttggg                                        449


<210>  32
<211>  436
<212>  DNA
<213>  Mus musculus

<400>  32
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      180

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      300

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtaagc ttgggg                                                      436


<210>  33
<211>  458
<212>  DNA
<213>  Mus musculus

<400>  33
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt cacttcagag       60

gttcagctgc agcagtctgg ggcagaactt gtgaaaccag gggcctcagt caagttgtcc      120

tgcacagctt ctggcttcaa cattaaagac acctatatgc actgggtgaa gcagaggcct      180

gaacagggcc tggagtggat tggaaggatt gatcctgcga atggtaatac tagatatgac      240

ccaaaattcc agggcaaggc cactataaca tcagacacat cctccaacac agcctacctg      300

cagctcagca gcctgacatc tgaggacact gccgtctatt actgtgctag gcgggtgggg      360

tactactttg actactgggg ccaaggcacc actctcacag tctcctcagc caaaacgaca      420

cccccatctg tctatcccct ggtccctgga agcttggg                              458


<210>  34
<211>  445
<212>  DNA
<213>  Mus musculus

<400>  34
atggaatcac agactcaggt cttcctctcc ctgctgctct gggtatctgg tacctgtggg       60

aacattatga tgacacagtc gccatcatct ctggctgtgt ctgcaggaga aaaggtcact      120

atgagctgta agtccagtca aagtgtttta tacagttcag atctgaagaa ctacttggcc      180

tggtaccagc agaaaccagg gcagtctcct acactgctga tctattgggc atccactagg      240

gaatctggtg tccctgatcg cttcacaggc agtggatctg ggacagattt tactcttacc      300

atcagcagtg tacaagctga agacctggca gtttattact gtcatcaata cctctcctcg      360

tacacgttcg gaggggggac caagctggaa ataaaacggg ctgatgctgc accaactgta      420

tccatcttcc caccatccag taagc                                            445


<210>  35
<211>  453
<212>  DNA
<213>  Mus musculus

<400>  35
atggattcac aggcccaggt tcttatgtta ctgctgctat gggtatctgg tacctgtggg       60

gacattgtga tgtcacaatc tccatcctcc ctagctgtgt cagttggaga gaaggttact      120

atgagctgca agtccagtca gagcctttta tatactggca atcaaaagaa ctacttggcc      180

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      240

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      300

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      360

ccgtggacgt tcggtggagg caccaagctg gaaatcaaac gggctgatgc tgcaccaact      420

gtatccatct tcccaccatc cagtaagctt ggg                                   453


